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2015 Vol. 40, No. 12
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2015, 40(12): 1617-1620,1623.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.001
Abstract:
Objective:To investigate of the effects of resveratrol(RES) on the invasion migration of Eca-109 cells and epithelial-mesenchymal transition(EMT) in esophageal squamous cell carcinoma.Methods:The Eca-109 cells were treated with different dilutions(50 and 100 μmol/L) of RES,then the wound-healing were performed.The cell migration and invasion was detected by transwell chamber assays.The mRNA and protein expressions of E-cadherin,N-cadherin,Vimentin,MMP-2 and MMP-9 were evaluated using real-time quantitative PCR and Western blot,respectively.Results:Compared with the control group,the other two RES treatment group(50 and 100 μmol/L) could significantly inhibit the Eca-109 cell invasion and migration(P<0.01),increase the mRNA and protein expressions of N-cadherin,Vimentin,MMP-2 and MMP-9(P<0.05 to P<0.01),and increase the mRNA and protein expression of E-cadherin(P<0.01).Conclusions:Resveratrol can inhibit the invasion and migration of Eca-109 cells,which can be caused by down-regulating expressions of the MMP-2 and MMP-9,regulating the expressions of EMT protein(E-cadherin,N-cadherin and Vimentin),and inhibiting the epithelial mesenchymal transition process.
Objective:To investigate of the effects of resveratrol(RES) on the invasion migration of Eca-109 cells and epithelial-mesenchymal transition(EMT) in esophageal squamous cell carcinoma.Methods:The Eca-109 cells were treated with different dilutions(50 and 100 μmol/L) of RES,then the wound-healing were performed.The cell migration and invasion was detected by transwell chamber assays.The mRNA and protein expressions of E-cadherin,N-cadherin,Vimentin,MMP-2 and MMP-9 were evaluated using real-time quantitative PCR and Western blot,respectively.Results:Compared with the control group,the other two RES treatment group(50 and 100 μmol/L) could significantly inhibit the Eca-109 cell invasion and migration(P<0.01),increase the mRNA and protein expressions of N-cadherin,Vimentin,MMP-2 and MMP-9(P<0.05 to P<0.01),and increase the mRNA and protein expression of E-cadherin(P<0.01).Conclusions:Resveratrol can inhibit the invasion and migration of Eca-109 cells,which can be caused by down-regulating expressions of the MMP-2 and MMP-9,regulating the expressions of EMT protein(E-cadherin,N-cadherin and Vimentin),and inhibiting the epithelial mesenchymal transition process.
2015, 40(12): 1621-1623.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.002
Abstract:
Objective:To explore the T cell immune response function in different clinical manifestation patients.Methods:The peripheral blood mononuclear cells were isolated.The T cell subgroup was detected using flow cytometry,and the immune response of T cell to HBV antigen protein was detected using enzyme-linked immunespots assay.Results:Compared with the acute hepatitis patients(group A),the frequency of CD4+ T cell subgroup in chronic hepatitis patients(group B) and asymptomatic carriers(group C) were significantly lower(P<0.01),and the differences of the frequency of CD8+ T cell subgroup in 3 groups were not statistically significant(P>0.05).Compared with group A,the ratios of CD4+/CD8+ in group B and group C were decreased(P<0.01).The spof forming call in group A was significantly less than that in group B and group C(P<0.01),and the spof forming call in group B was significantly less than that in group C(P<0.01).Conclusions:T cell immune in patients with different clinical manifestations is different,and the dysequilibrium of T cell subgroup may lead to immune disorders,and can not clear the virus,which is the cause of different clinical symptoms.
Objective:To explore the T cell immune response function in different clinical manifestation patients.Methods:The peripheral blood mononuclear cells were isolated.The T cell subgroup was detected using flow cytometry,and the immune response of T cell to HBV antigen protein was detected using enzyme-linked immunespots assay.Results:Compared with the acute hepatitis patients(group A),the frequency of CD4+ T cell subgroup in chronic hepatitis patients(group B) and asymptomatic carriers(group C) were significantly lower(P<0.01),and the differences of the frequency of CD8+ T cell subgroup in 3 groups were not statistically significant(P>0.05).Compared with group A,the ratios of CD4+/CD8+ in group B and group C were decreased(P<0.01).The spof forming call in group A was significantly less than that in group B and group C(P<0.01),and the spof forming call in group B was significantly less than that in group C(P<0.01).Conclusions:T cell immune in patients with different clinical manifestations is different,and the dysequilibrium of T cell subgroup may lead to immune disorders,and can not clear the virus,which is the cause of different clinical symptoms.
2015, 40(12): 1624-1627.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.003
Abstract:
Objective:To observe the effects of berberine on the toxicity of CDDP,and its mechanism.Methods:The cell survival rate,and expressions of IκBα and p65 in CDDP-resistant A549 cell line(A549/CDDP) were measured by MTT assay and westen blotting,respectively.The expression of p65 was silenced by p65 siRNA transfecting the A549/CDDP cells,which was used to decrease the NF-κB activity.Results:Compared with the CDDP sensitive cells(A549 cells),the expressions of p65 and IκBα increased and decreased significantly in A549/CDDP cells,respectively(P<0.01).The activity of NF-κB was decreased by the p65 siRNA silencing the expression of p65 in A549/CDDP cells,which could reversed the CDDP resistance(P<0.01).The 20 μmol/L berberine could obviously enhance the sensitivity of A549/CDDP cells to CDDP,and 5 to 20 μmol/L berberine could decreased the expression of p65 in a dose-dependent manner,while the expression of IκBα was obviously enhanced by berberine(P<0.01).Conclusions:Berberine can reverse the resistance of A549 lung adenocarcinoma cells to cisplatin by inhibiting NF-κB.
Objective:To observe the effects of berberine on the toxicity of CDDP,and its mechanism.Methods:The cell survival rate,and expressions of IκBα and p65 in CDDP-resistant A549 cell line(A549/CDDP) were measured by MTT assay and westen blotting,respectively.The expression of p65 was silenced by p65 siRNA transfecting the A549/CDDP cells,which was used to decrease the NF-κB activity.Results:Compared with the CDDP sensitive cells(A549 cells),the expressions of p65 and IκBα increased and decreased significantly in A549/CDDP cells,respectively(P<0.01).The activity of NF-κB was decreased by the p65 siRNA silencing the expression of p65 in A549/CDDP cells,which could reversed the CDDP resistance(P<0.01).The 20 μmol/L berberine could obviously enhance the sensitivity of A549/CDDP cells to CDDP,and 5 to 20 μmol/L berberine could decreased the expression of p65 in a dose-dependent manner,while the expression of IκBα was obviously enhanced by berberine(P<0.01).Conclusions:Berberine can reverse the resistance of A549 lung adenocarcinoma cells to cisplatin by inhibiting NF-κB.
2015, 40(12): 1628-1630,1634.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.004
Abstract:
Objective:To investigate the signal transduction and expression of STAT4 and STAT6 in placenta of preeclampsia patients and its significance.Methods:The expressions and location of STAT4 and STAT6 in placenta of 30 normal late pregnant women(control group) and 50 preeclampsia patients(including 22 mild cases and 28 severe cases) were observed using Western blot and immunohistochemistry,respectively.Results:The expressions of STAT4 and STAT6 located mainly in the cytoplasm of villous trophoblast cell,the most nucleus were no clear coloring.The expressions of STAT4 and STAT6 were significantly higher and lower than those of control group,respectively(P<0.01).The differences of the expressions between STAT4 and STAT6 in placenta of mild and severe preeclampsia patients were statistically significant(P<0.01).The expressions of STAT4 in the cytoplasm of villous trophoblast cell in two groups were negative correlation with the level of STAT6(r=-0.509,r=-0.617;P<0.01).Conclusions:Both STAT4 and STAT6 paticipate the pathogenic process of preeclampsia,and are related to the severe degree of disease.The high expression of STAT4 and low expression of STAT6 in the villous trophoblast cell of preeclampsia patients can lead to Th1/Th2 imbalance,which may lead to the preeclampsia.
Objective:To investigate the signal transduction and expression of STAT4 and STAT6 in placenta of preeclampsia patients and its significance.Methods:The expressions and location of STAT4 and STAT6 in placenta of 30 normal late pregnant women(control group) and 50 preeclampsia patients(including 22 mild cases and 28 severe cases) were observed using Western blot and immunohistochemistry,respectively.Results:The expressions of STAT4 and STAT6 located mainly in the cytoplasm of villous trophoblast cell,the most nucleus were no clear coloring.The expressions of STAT4 and STAT6 were significantly higher and lower than those of control group,respectively(P<0.01).The differences of the expressions between STAT4 and STAT6 in placenta of mild and severe preeclampsia patients were statistically significant(P<0.01).The expressions of STAT4 in the cytoplasm of villous trophoblast cell in two groups were negative correlation with the level of STAT6(r=-0.509,r=-0.617;P<0.01).Conclusions:Both STAT4 and STAT6 paticipate the pathogenic process of preeclampsia,and are related to the severe degree of disease.The high expression of STAT4 and low expression of STAT6 in the villous trophoblast cell of preeclampsia patients can lead to Th1/Th2 imbalance,which may lead to the preeclampsia.
2015, 40(12): 1631-1634.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.005
Abstract:
Objective:To investigate the short-term effects and adverse reactions of the large dose of methotrexate(MTX),cisplatin(PPD) combined with adriamycin(ADR) in the chemotherapy of osteosarcoma.Methods:Thirty extremity osteosarcoma patients(ⅡB phase) diagnosed by histopathology and imaging were investigated.All patients were treated with the high dose of MTX,PDD combined with ADR,21 days for a cycle.The artificial joint replacement or amputation were implemented according to the MRI and plain film of lesions after 3 to 4 cycles of treatment.The curative effects were evaluated by the salvage success rate and tumor tissue necrosis rate according to the postoperative osteosarcoma pathological examination.Results:The tumor necrosis in more than 90% patients was identified by the result of postoperative pathological examination of osteosarcoma,the rates of tumor necrosis and salvage success were 86.7% and 53.0%,respectively.All the incidences of nausea and vomiting,hair loss and neutrophilopenia were 100.0%.The rates of hemoglobin reducing and white blood cell increasing were 86.7% and 16.7%,respectively.The incidences of oral and intestinal mucositis,and liver dysfunction were 26.7% and 13.3%,respectively.Conclusions:The treatment of osteosarcoma with high dose MTX,PDD combined with ADR is high tumor tissue necrosis and limb salvage rate,good curative effect and tolerable adverse reactions,which is worthy of clinical use.
Objective:To investigate the short-term effects and adverse reactions of the large dose of methotrexate(MTX),cisplatin(PPD) combined with adriamycin(ADR) in the chemotherapy of osteosarcoma.Methods:Thirty extremity osteosarcoma patients(ⅡB phase) diagnosed by histopathology and imaging were investigated.All patients were treated with the high dose of MTX,PDD combined with ADR,21 days for a cycle.The artificial joint replacement or amputation were implemented according to the MRI and plain film of lesions after 3 to 4 cycles of treatment.The curative effects were evaluated by the salvage success rate and tumor tissue necrosis rate according to the postoperative osteosarcoma pathological examination.Results:The tumor necrosis in more than 90% patients was identified by the result of postoperative pathological examination of osteosarcoma,the rates of tumor necrosis and salvage success were 86.7% and 53.0%,respectively.All the incidences of nausea and vomiting,hair loss and neutrophilopenia were 100.0%.The rates of hemoglobin reducing and white blood cell increasing were 86.7% and 16.7%,respectively.The incidences of oral and intestinal mucositis,and liver dysfunction were 26.7% and 13.3%,respectively.Conclusions:The treatment of osteosarcoma with high dose MTX,PDD combined with ADR is high tumor tissue necrosis and limb salvage rate,good curative effect and tolerable adverse reactions,which is worthy of clinical use.
2015, 40(12): 1635-1637.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.006
Abstract:
Objective:To detect the expression of TIP30/CC3 in nasopharyngeal carcinoma tissue,and its role in tumor metastasis.Methods:The expressions of TIP30/CC3 in 30 non-nasopharyngeal carcinoma and 60 nasopharyngeal carcinoma tissue samples were detected by immunohistochemical S-P method,and the relationship between the clinical and pathological parameters was analyzed.Results:The positive expression rate of TIP30/CC3 in non-nasopharyngeal carcinoma tissue(66.7%) was higher than that in nasopharyngeal carcinoma tissue(43.5%)(P<0.01).The differences of the expression rate of TIP30/CC3 in nasopharyngeal carcinoma tissue of patients with different T stage,pathological type,age and gender were not statistically significant(P>0.05).The expression of TIP30/CC3 in nasopharyngeal carcinoma tissue with lymph node metastasis(N2)(31.0%) was lower than that in nasopharyngeal carcinoma tissue without lymph node metastasis(72.2%)(P<0.05).Conclusions:The expressions of TIP30/CC3 in non-nasopharyngeal carcinoma and nasopharyngeal carcinoma tissue are high and low,respectively.The low expression of TIP30/CC3 in nasopharyngeal carcinoma tissue is related to the lymph node metastasis,which suggests that the TIP30/CC3 may be the important index in the occurrence,development,metastasis and prognosis of nasopharyngeal carcinoma.
Objective:To detect the expression of TIP30/CC3 in nasopharyngeal carcinoma tissue,and its role in tumor metastasis.Methods:The expressions of TIP30/CC3 in 30 non-nasopharyngeal carcinoma and 60 nasopharyngeal carcinoma tissue samples were detected by immunohistochemical S-P method,and the relationship between the clinical and pathological parameters was analyzed.Results:The positive expression rate of TIP30/CC3 in non-nasopharyngeal carcinoma tissue(66.7%) was higher than that in nasopharyngeal carcinoma tissue(43.5%)(P<0.01).The differences of the expression rate of TIP30/CC3 in nasopharyngeal carcinoma tissue of patients with different T stage,pathological type,age and gender were not statistically significant(P>0.05).The expression of TIP30/CC3 in nasopharyngeal carcinoma tissue with lymph node metastasis(N2)(31.0%) was lower than that in nasopharyngeal carcinoma tissue without lymph node metastasis(72.2%)(P<0.05).Conclusions:The expressions of TIP30/CC3 in non-nasopharyngeal carcinoma and nasopharyngeal carcinoma tissue are high and low,respectively.The low expression of TIP30/CC3 in nasopharyngeal carcinoma tissue is related to the lymph node metastasis,which suggests that the TIP30/CC3 may be the important index in the occurrence,development,metastasis and prognosis of nasopharyngeal carcinoma.
2015, 40(12): 1638-1640.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.007
Abstract:
Objective:To analyze the clinical efficacy of the D3 radical surgery under laparoscopy in the treatment of right colon cancer.Methods:Ninety patients with right colon cancer in our department from March 2009 to March 2013 were randomly divided into the observation group and control group.The observation group were treated with the D3 radical surgery under laparoscopy,and the control group were treated with the traditional open surgery.The general surgery condition,score of postoperative quality of life,postoperative 1,3-year disease-free survival and overall survival rates and postoperative complication in two groups were compared.Results:The operative time,blood loss,recovery time of hospital stay intestinal exhaust in observation group were significantly shorter than those in control group(P<0.01).The scores of the postoperative physiological function,psychological function,emotional function and social function in observation group were significantly lower than those in control group(P<0.01).The 3-year disease-free survival rate,and 1,3-year overall survival rate in observation group were significantly higher than those in control group(P<0.05 to P<0.01).The difference of the postoperative wound infection rate between two groups was not statistically significant(P>0.05).Conclusions:Compared with traditional open surgery,the D3 radical surgery under laparoscopy in the treatment of right colon cancer is fewer trauma,good effect,less postoperative recurrence rate and high security,which is worthy of clinical application.
Objective:To analyze the clinical efficacy of the D3 radical surgery under laparoscopy in the treatment of right colon cancer.Methods:Ninety patients with right colon cancer in our department from March 2009 to March 2013 were randomly divided into the observation group and control group.The observation group were treated with the D3 radical surgery under laparoscopy,and the control group were treated with the traditional open surgery.The general surgery condition,score of postoperative quality of life,postoperative 1,3-year disease-free survival and overall survival rates and postoperative complication in two groups were compared.Results:The operative time,blood loss,recovery time of hospital stay intestinal exhaust in observation group were significantly shorter than those in control group(P<0.01).The scores of the postoperative physiological function,psychological function,emotional function and social function in observation group were significantly lower than those in control group(P<0.01).The 3-year disease-free survival rate,and 1,3-year overall survival rate in observation group were significantly higher than those in control group(P<0.05 to P<0.01).The difference of the postoperative wound infection rate between two groups was not statistically significant(P>0.05).Conclusions:Compared with traditional open surgery,the D3 radical surgery under laparoscopy in the treatment of right colon cancer is fewer trauma,good effect,less postoperative recurrence rate and high security,which is worthy of clinical application.
2015, 40(12): 1641-1642,1645.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.008
Abstract:
Objective:To observe the clinical effects of laparoscopic surgery in the treatment of ectopic pregnancy.Methods:One hundred and thirty-two patients with ectopic pregnancy treated with laparoscopic surgery and 63 patients with ectopic pregnancy treated with laparotomy were divided into the observation group and control group,respectively.The clinical effects between two groups were compared.Results:The operations in two groups were successfully completed.The operative time,and peroperative bleeding,anal exhaust time and hospital stays in observation group were significantly less than those in control group(P<0.01).Conclusions:The treatment of ectopic pregnancy with laparoscopic surgery is high accuracy,less trauma,quick recovery,less complication and safety,which should be the first chosen in treating ectopic pregnancy.
Objective:To observe the clinical effects of laparoscopic surgery in the treatment of ectopic pregnancy.Methods:One hundred and thirty-two patients with ectopic pregnancy treated with laparoscopic surgery and 63 patients with ectopic pregnancy treated with laparotomy were divided into the observation group and control group,respectively.The clinical effects between two groups were compared.Results:The operations in two groups were successfully completed.The operative time,and peroperative bleeding,anal exhaust time and hospital stays in observation group were significantly less than those in control group(P<0.01).Conclusions:The treatment of ectopic pregnancy with laparoscopic surgery is high accuracy,less trauma,quick recovery,less complication and safety,which should be the first chosen in treating ectopic pregnancy.
2015, 40(12): 1643-1645.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.009
Abstract:
Objective:To analyze the clinical efficacy of levocarnitine in the treatment of ischemic cardiomyopathy(IHD) heart failure,and its effects on myocardial cell function.Methods:One hundred and thirty-six patients with ischemic cardiomyopathy heart failure were randomly divided into the observation group and control group(68 cases in each group).The control group were treated with conventional method,and the observation group were additionally treated with 3.0 g carnitine by intravenous drip once a day for 14 days on the basis of conventional treatment.The clinical efficacy,left ventricular ejection fraction(LVEF) before treatment and after 14 days of treatment,stroke volume(SV),cardiac output(CO),type B urine sodium peptide(BNP) and 6 min walking distance between two groups were compared.Results:The total effective rate after 3 months of treatment in observation group(96.6%) was significant higher than that in control group(84.8%)(P<0.01).The differences of the mortality and hospitalization rate during the 1 year following-up between two groups were statistically significant(P>0.05).The LVEF,SV,CO,BNP and 6 min walking distance in two groups after 3 months of treatment were improved(P<0.01),but the improvement in observation group were more significantly(P<0.01).The blood routine,liver and kidney functions in two groups during the treatment period were normal,the main adverse reactions included dry mouth and gastrointestinal reaction,and difference of the incidence of adverse reactions between two groups was not statistically significant(P>0.05).Conclusions:L-carnitine can obviously improve the clinical symptoms of patients with ischemic cardiomyopathy heart failure and heart function,which is high safety and worthy of clinical promotion.
Objective:To analyze the clinical efficacy of levocarnitine in the treatment of ischemic cardiomyopathy(IHD) heart failure,and its effects on myocardial cell function.Methods:One hundred and thirty-six patients with ischemic cardiomyopathy heart failure were randomly divided into the observation group and control group(68 cases in each group).The control group were treated with conventional method,and the observation group were additionally treated with 3.0 g carnitine by intravenous drip once a day for 14 days on the basis of conventional treatment.The clinical efficacy,left ventricular ejection fraction(LVEF) before treatment and after 14 days of treatment,stroke volume(SV),cardiac output(CO),type B urine sodium peptide(BNP) and 6 min walking distance between two groups were compared.Results:The total effective rate after 3 months of treatment in observation group(96.6%) was significant higher than that in control group(84.8%)(P<0.01).The differences of the mortality and hospitalization rate during the 1 year following-up between two groups were statistically significant(P>0.05).The LVEF,SV,CO,BNP and 6 min walking distance in two groups after 3 months of treatment were improved(P<0.01),but the improvement in observation group were more significantly(P<0.01).The blood routine,liver and kidney functions in two groups during the treatment period were normal,the main adverse reactions included dry mouth and gastrointestinal reaction,and difference of the incidence of adverse reactions between two groups was not statistically significant(P>0.05).Conclusions:L-carnitine can obviously improve the clinical symptoms of patients with ischemic cardiomyopathy heart failure and heart function,which is high safety and worthy of clinical promotion.
2015, 40(12): 1646-1648.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.010
Abstract:
Objective:To investigate the monitoring value of quantitative electroencephalogram(qEEG) in the patients with massive cerebral infarction complicated with cerebral edema.Methods:Thirty elderly patients with massive cerebral infarction complicated with cerebral edema and 30 examination elderly people were divided into the observation group and control group.The qEEG detected by the Bio-Logic electroencephalograph,DTABR,intracranial brain edema volume and National Institutes of Health Stroke Scale(NIHSS) in all patients were compared and analyzed within 6 h(T1),24 h(T2),72 h(T3) and 168 h(T4) of the onset of disease.Results:The DTABR in observation group was higher than that in control group(P<0.01),5 cases in observation group died during the treatment.The results of DTABR,cerebral edema volume and NIHSS score at each stage showed that the difference of which between T1 and T2 was not statistically significant(P>0.05).The change trends of DTABR index,NIHSS score and cerebral edema volume were similar,which arrived at the peak after 72 h,and began to decrease with the course of disease alleviating.The DTABR of the cure patients in observation group increased from T1 to T3,arrived at the peak,and gradually began to decrease from T3 to T4,while the declining trend of DTABR at T3 and T4 in the unhealed patients was not found.Conclusions:The qEEG can objectively and effectively evaluate the brain function in the patients with massive cerebral infarction complicated with cerebral edema,which can be expected to become an important bedside assessment means of brain function in neurological intensive care unit.
Objective:To investigate the monitoring value of quantitative electroencephalogram(qEEG) in the patients with massive cerebral infarction complicated with cerebral edema.Methods:Thirty elderly patients with massive cerebral infarction complicated with cerebral edema and 30 examination elderly people were divided into the observation group and control group.The qEEG detected by the Bio-Logic electroencephalograph,DTABR,intracranial brain edema volume and National Institutes of Health Stroke Scale(NIHSS) in all patients were compared and analyzed within 6 h(T1),24 h(T2),72 h(T3) and 168 h(T4) of the onset of disease.Results:The DTABR in observation group was higher than that in control group(P<0.01),5 cases in observation group died during the treatment.The results of DTABR,cerebral edema volume and NIHSS score at each stage showed that the difference of which between T1 and T2 was not statistically significant(P>0.05).The change trends of DTABR index,NIHSS score and cerebral edema volume were similar,which arrived at the peak after 72 h,and began to decrease with the course of disease alleviating.The DTABR of the cure patients in observation group increased from T1 to T3,arrived at the peak,and gradually began to decrease from T3 to T4,while the declining trend of DTABR at T3 and T4 in the unhealed patients was not found.Conclusions:The qEEG can objectively and effectively evaluate the brain function in the patients with massive cerebral infarction complicated with cerebral edema,which can be expected to become an important bedside assessment means of brain function in neurological intensive care unit.
2015, 40(12): 1649-1650.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.011
Abstract:
Objective:To explore the relationships between the blood lipids,apolipoprotein and type 2 diabetes mellitus complicated with chronic complication,and its significance.Methods:Sixty-five type 2 diabetic patients and 57 healthy people were divided into the case group and control group,respectively.The levels of serum lipids and apolipoproteins in morning fasting venous blood of two groups after 12 h of fasting were measured by automatic biochemical analyzer,and analyzed statistically.Results:The serum levels of triglyceride,total cholesterol,low density lipoprotein,apolipoprotein B and ratio of apolipoprotein B/apolipoprotein A1 in case group were significantly higher than those in control group(P<0.01),while the serum levels of high density lipoprotein and apolipoprotein A1 in case group were significantly lower than those in control group(P<0.01).Conclusions:The blood lipid level in type 2 diabetes mellitus is obviously abnormal,and the early intervention treatment of blood lipid has very important significance.
Objective:To explore the relationships between the blood lipids,apolipoprotein and type 2 diabetes mellitus complicated with chronic complication,and its significance.Methods:Sixty-five type 2 diabetic patients and 57 healthy people were divided into the case group and control group,respectively.The levels of serum lipids and apolipoproteins in morning fasting venous blood of two groups after 12 h of fasting were measured by automatic biochemical analyzer,and analyzed statistically.Results:The serum levels of triglyceride,total cholesterol,low density lipoprotein,apolipoprotein B and ratio of apolipoprotein B/apolipoprotein A1 in case group were significantly higher than those in control group(P<0.01),while the serum levels of high density lipoprotein and apolipoprotein A1 in case group were significantly lower than those in control group(P<0.01).Conclusions:The blood lipid level in type 2 diabetes mellitus is obviously abnormal,and the early intervention treatment of blood lipid has very important significance.
2015, 40(12): 1651-1654.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.012
Abstract:
Objective:To explore the feasibility of bedside skull rinse under local anesthesia drainage in the treatment of chronic subdural hematoma(CSDH).Methods:Among 216 CSDH patients,123 cases were treated with bedside skull rinse under local anesthesia drainage(skull rinse group),and 93 cases were treated with traditional drilling drainage(drilling drainage group).The curative effects,hematoma recurrence,length of hospital stay,hospitalization cost and complications between two groups were compared.Results:The differences of curative effects and hematoma recurrence between two groups were not statistically significant(P>0.05).The length of hospital stay and hospitalization cost in skull rinse group were significantly less than those in drilling drainage group(P>0/01).Conclusions:The bedside skull rinse under local anesthesia drainage treating CSDH is safe,reliable and economic,which is worthy of further promotion.
Objective:To explore the feasibility of bedside skull rinse under local anesthesia drainage in the treatment of chronic subdural hematoma(CSDH).Methods:Among 216 CSDH patients,123 cases were treated with bedside skull rinse under local anesthesia drainage(skull rinse group),and 93 cases were treated with traditional drilling drainage(drilling drainage group).The curative effects,hematoma recurrence,length of hospital stay,hospitalization cost and complications between two groups were compared.Results:The differences of curative effects and hematoma recurrence between two groups were not statistically significant(P>0.05).The length of hospital stay and hospitalization cost in skull rinse group were significantly less than those in drilling drainage group(P>0/01).Conclusions:The bedside skull rinse under local anesthesia drainage treating CSDH is safe,reliable and economic,which is worthy of further promotion.
2015, 40(12): 1655-1657.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.013
Abstract:
Objective:To explore the application value of suspended laparoscopy in myomectomy.Methods:Forty patients were divided into the suspended group(20 cases treated with suspended laparoscopy in myomectomy) and laparotomy group(20 cases treated with laparoscopy in myomectomy).The operation time,intraoperative blood loss,myoma diameter,postoperative pain score,and hospitalization and hospitalization cost between two groups were compared.Results:The operations of two groups were successfully completed.The differences of operation time and diameter of myoma between two groups were not statistical significance(P>0.05).The intraoperative blood loss and hospitalization time in suspended group were less than those in laparotomy group(P<0.01 and P<0.05).The postoperative pain score and exhaust time in suspended group were significantly lower and earlier than those in laparotomy group,respectively(P<0.01).The hospitalization cost in suspended group was significantly higher than that in laparotomy group(P<0.01).Conclusions:The clinical application of suspended laparoscopy in myomectomy is high safety,easy operation,beautiful incision,quick recovery,light pain and short hospitalization time.
Objective:To explore the application value of suspended laparoscopy in myomectomy.Methods:Forty patients were divided into the suspended group(20 cases treated with suspended laparoscopy in myomectomy) and laparotomy group(20 cases treated with laparoscopy in myomectomy).The operation time,intraoperative blood loss,myoma diameter,postoperative pain score,and hospitalization and hospitalization cost between two groups were compared.Results:The operations of two groups were successfully completed.The differences of operation time and diameter of myoma between two groups were not statistical significance(P>0.05).The intraoperative blood loss and hospitalization time in suspended group were less than those in laparotomy group(P<0.01 and P<0.05).The postoperative pain score and exhaust time in suspended group were significantly lower and earlier than those in laparotomy group,respectively(P<0.01).The hospitalization cost in suspended group was significantly higher than that in laparotomy group(P<0.01).Conclusions:The clinical application of suspended laparoscopy in myomectomy is high safety,easy operation,beautiful incision,quick recovery,light pain and short hospitalization time.
2015, 40(12): 1658-1660,1663.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.014
Abstract:
Objective:To evaluate the forecasting function of the coronary artery calcium score(CACS) on the increasing of cardiac Troponin I(cTnI) and Brain Natriuretic Peptide(BNP) levels in unstable angina pectoris after left anterior descending artery stenting.Methods:The levels of BNP and cTnI,and 64-slice coronary CTA scanning and CACS in 480 patients with unstable angina pectoris were detected before left anterior descending artery stenting.The patients were divided into group A(315 cases,CACS less than 100 points) and group B(165 cases,CACS equal to or more than 100 points) according to the left anterior descending artery calcification score.The levels of BNP and cTnI in all cases were measured after 24 h of left anterior descending artery stenting.Results:The differences of the preoperative levels of cTnI and BNP in group A and group B were not statistically significant(P>0.05).The postoperative levels of cTnI and BNP in group A and group B were significantly higher than the preoperative levels(P<0.01),and the postoperative levels of cTnI and BNP in group B were higher than those in group A(P<0.01).Conclusions:The high CACS has certain predictive value in the levels of cTnI and BNP after left anterior descending artery stenting.
Objective:To evaluate the forecasting function of the coronary artery calcium score(CACS) on the increasing of cardiac Troponin I(cTnI) and Brain Natriuretic Peptide(BNP) levels in unstable angina pectoris after left anterior descending artery stenting.Methods:The levels of BNP and cTnI,and 64-slice coronary CTA scanning and CACS in 480 patients with unstable angina pectoris were detected before left anterior descending artery stenting.The patients were divided into group A(315 cases,CACS less than 100 points) and group B(165 cases,CACS equal to or more than 100 points) according to the left anterior descending artery calcification score.The levels of BNP and cTnI in all cases were measured after 24 h of left anterior descending artery stenting.Results:The differences of the preoperative levels of cTnI and BNP in group A and group B were not statistically significant(P>0.05).The postoperative levels of cTnI and BNP in group A and group B were significantly higher than the preoperative levels(P<0.01),and the postoperative levels of cTnI and BNP in group B were higher than those in group A(P<0.01).Conclusions:The high CACS has certain predictive value in the levels of cTnI and BNP after left anterior descending artery stenting.
2015, 40(12): 1661-1663.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.015
Abstract:
Objective:To observe the clinical efficacy of L-carnitine combined with hemodialysis in the treatment of uremic peripheral neuropathy.Methods:Seventy-six patients with uremic peripheral neuropathy were randomly divided into the control group and observation group(38 cases each group).The control group and observation group were treated with ordinary hemodialysis and L-carnitine combined with hemodialysis,respectively.The curative efficacy and nerve conduction velocity between two groups were compared.Results:Compared with before treatment,the sensory nerve conduction velocity in observation group significantly increased(P<0.01),and the level of which was significantly higher than that in control group after treatment(P<0.01).The total effective rate in observation group(86.8%) was significantly higher than that in control group(57.9%)(P<0.01).Conclusions:The treatment of uremic patients with peripheral neuropathy with L-carnitine combined with hemodialysis can significantly improve the symptom of patients,which is effective and simple.
Objective:To observe the clinical efficacy of L-carnitine combined with hemodialysis in the treatment of uremic peripheral neuropathy.Methods:Seventy-six patients with uremic peripheral neuropathy were randomly divided into the control group and observation group(38 cases each group).The control group and observation group were treated with ordinary hemodialysis and L-carnitine combined with hemodialysis,respectively.The curative efficacy and nerve conduction velocity between two groups were compared.Results:Compared with before treatment,the sensory nerve conduction velocity in observation group significantly increased(P<0.01),and the level of which was significantly higher than that in control group after treatment(P<0.01).The total effective rate in observation group(86.8%) was significantly higher than that in control group(57.9%)(P<0.01).Conclusions:The treatment of uremic patients with peripheral neuropathy with L-carnitine combined with hemodialysis can significantly improve the symptom of patients,which is effective and simple.
2015, 40(12): 1664-1665,1668.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.016
Abstract:
Objective:To explore relationship between the redox reaction and male patients with type 2 diabetes erectile dysfunction(DED) to provide the new reference in the diagnosis and treatment of DED.Methods:Sixty middle-aged men were divided into the control group,type 2 diabetes non-erectile dysfunction(NED group) and type 2 diabetes erectile dysfunction group(DED group)(20 cases each group).The serum levels of peroxidation product 4-hydroxynonenal(4-HNE),Malonaldehyde(MDA) and Nitric oxide(NO) were detected,the relationship between peroxidation and DED was identified.Results:The body mass index(BMI) and Glycated hemoglobin(HbA1c) in DED group were significantly higher than those in NED group and control group(P<0.01),the HbA1c level in NED group was significantly higher than that in control group(P<0.01).The total testosterone and IIEF-5 in DED group were significantly less than those in NED group and control group(P<0.01),the total testosterone level in NED group was significantly less than that in control group(P<0.01).The serum levels of 4-HNE and MDA in DED group were significantly higher than those in NED group and control group(P<0.01),the MDA level in NED group was higher than that in control group(P<0.05).The serum level of NO in DED group was significantly less than that in NED group and control group(P<0.01),the serum level of NO in NED group was significantly less than that in control group(P<0.01).Conclusions:Redox reaction play a promotion role in the development and occurrence of DED by the penile vascular endothelial injury mediated by NO.
Objective:To explore relationship between the redox reaction and male patients with type 2 diabetes erectile dysfunction(DED) to provide the new reference in the diagnosis and treatment of DED.Methods:Sixty middle-aged men were divided into the control group,type 2 diabetes non-erectile dysfunction(NED group) and type 2 diabetes erectile dysfunction group(DED group)(20 cases each group).The serum levels of peroxidation product 4-hydroxynonenal(4-HNE),Malonaldehyde(MDA) and Nitric oxide(NO) were detected,the relationship between peroxidation and DED was identified.Results:The body mass index(BMI) and Glycated hemoglobin(HbA1c) in DED group were significantly higher than those in NED group and control group(P<0.01),the HbA1c level in NED group was significantly higher than that in control group(P<0.01).The total testosterone and IIEF-5 in DED group were significantly less than those in NED group and control group(P<0.01),the total testosterone level in NED group was significantly less than that in control group(P<0.01).The serum levels of 4-HNE and MDA in DED group were significantly higher than those in NED group and control group(P<0.01),the MDA level in NED group was higher than that in control group(P<0.05).The serum level of NO in DED group was significantly less than that in NED group and control group(P<0.01),the serum level of NO in NED group was significantly less than that in control group(P<0.01).Conclusions:Redox reaction play a promotion role in the development and occurrence of DED by the penile vascular endothelial injury mediated by NO.
2015, 40(12): 1666-1668.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.017
Abstract:
Objective:To investigate the histopathology of endometrium in patients with abnormal uterine bleeding and distribution of various types of endometrium in different age patients.Methods:The data of the histopathology of endometrium in 294 cases with abnormal uterine bleeding were retrospectively analyzed.Results:The difference of the histopathology distribution of endometrium in different age patients with abnormal uterine bleeding was no statistical significance(P>0.05).The differences of the types of endometrial hyperplasia and polyp in different age patients were not statistical significance(P>0.05).Conclusions:The endometrial lesion in patient with abnormal uterine bleeding is not related to their age.
Objective:To investigate the histopathology of endometrium in patients with abnormal uterine bleeding and distribution of various types of endometrium in different age patients.Methods:The data of the histopathology of endometrium in 294 cases with abnormal uterine bleeding were retrospectively analyzed.Results:The difference of the histopathology distribution of endometrium in different age patients with abnormal uterine bleeding was no statistical significance(P>0.05).The differences of the types of endometrial hyperplasia and polyp in different age patients were not statistical significance(P>0.05).Conclusions:The endometrial lesion in patient with abnormal uterine bleeding is not related to their age.
2015, 40(12): 1669-1672.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.018
Abstract:
Objective:To investigate the causes and characteristics of pesticide poisoning for providing the evidence in formulating the prevention and control strategies.Methods:The clinical data of 655 patients with pesticide poisoning from 2009 to 2013 were described in three fields and general features.Results:Among 655 cases with pesticide poisoning,29 cases died,the fatality rate of which was 4.43%.The fatality rate of 582 cases with life-pesticide poisoning was 4.81%.The 93.99% of life-pesticide poisoning was suicide patients using pesticide,the young women and elderly were the majority.The fatality rate of patients with pre-hospital treatment was less than that in patients without pre-hospital treatment(P<0.05).Conclusions:Pesticide poisoning has become a serious public health problem.Developing extensive health and safety publicity education,strengthening pesticide management,psychological intervention and technical training before hospital,and further improving the monitoring of pesticide poisoning should be implemented.
Objective:To investigate the causes and characteristics of pesticide poisoning for providing the evidence in formulating the prevention and control strategies.Methods:The clinical data of 655 patients with pesticide poisoning from 2009 to 2013 were described in three fields and general features.Results:Among 655 cases with pesticide poisoning,29 cases died,the fatality rate of which was 4.43%.The fatality rate of 582 cases with life-pesticide poisoning was 4.81%.The 93.99% of life-pesticide poisoning was suicide patients using pesticide,the young women and elderly were the majority.The fatality rate of patients with pre-hospital treatment was less than that in patients without pre-hospital treatment(P<0.05).Conclusions:Pesticide poisoning has become a serious public health problem.Developing extensive health and safety publicity education,strengthening pesticide management,psychological intervention and technical training before hospital,and further improving the monitoring of pesticide poisoning should be implemented.
2015, 40(12): 1673-1674,1677.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.019
Abstract:
Objective:To investigate the risk factors of intestinal necrosis in incarcerated femoral hernia.Methods:The clinical characteristics of 108 patients with incarcerated femoral hernia were retrospectively analyzed.The risk factors of intestinal necrosis were analysed using logistic regression analysis.Results:Ten (9.26%) patients were treated with intestinal resection.Taking anticoagulants by oral(OR=9.8) and duration of symptoms longer than 3 days(OR=2.3) were the related factors of intestinal necrosisConclusions:Taking anticoagulants by oral and duration of symptoms longer than 3 days in the patients are the related risk factors of intestinal necrosis.The early diagnosis,rapid preoperative assessment and emergency surgery can significantly reduce the fatality rate of the intestinal necrosis patients with incarcerated femoral hernia.
Objective:To investigate the risk factors of intestinal necrosis in incarcerated femoral hernia.Methods:The clinical characteristics of 108 patients with incarcerated femoral hernia were retrospectively analyzed.The risk factors of intestinal necrosis were analysed using logistic regression analysis.Results:Ten (9.26%) patients were treated with intestinal resection.Taking anticoagulants by oral(OR=9.8) and duration of symptoms longer than 3 days(OR=2.3) were the related factors of intestinal necrosisConclusions:Taking anticoagulants by oral and duration of symptoms longer than 3 days in the patients are the related risk factors of intestinal necrosis.The early diagnosis,rapid preoperative assessment and emergency surgery can significantly reduce the fatality rate of the intestinal necrosis patients with incarcerated femoral hernia.
2015, 40(12): 1675-1677.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.020
Abstract:
Objective:To compare the effects between mini invasive percutaneous nephrolithotomy(MPCNL) and retroperitoneal laparoscopic ureterolithotomy(RLU) in the treatment of complex ureteral calculi.Methods:The clinical data in 142 patients with the complex ureteral calculi were retrospectively analyzed from May 2011 to May 2015.The patients were divided into the MPCNL group and RLU group according to the surgical method.The clinical efficacy and safety between two groups were compared.Results:The hospital stay,operative time and stone-free cases at postoperative 3 days in RLU group were significantly less than those in MPCNL group(P<0.01 to P<0.05).The differences of D-J indwelling time,stone-free cases at postoperative 1 month,incidence of postoperative complications and hospitalization cost between two groups were not statistically significant(P>0.05).Conclusions:The effects of MPCNL and RLU in the treatment of complex ureteral calculi are good.The RLU is quick recovery and high stone-free,which is worthy of further clinical application.
Objective:To compare the effects between mini invasive percutaneous nephrolithotomy(MPCNL) and retroperitoneal laparoscopic ureterolithotomy(RLU) in the treatment of complex ureteral calculi.Methods:The clinical data in 142 patients with the complex ureteral calculi were retrospectively analyzed from May 2011 to May 2015.The patients were divided into the MPCNL group and RLU group according to the surgical method.The clinical efficacy and safety between two groups were compared.Results:The hospital stay,operative time and stone-free cases at postoperative 3 days in RLU group were significantly less than those in MPCNL group(P<0.01 to P<0.05).The differences of D-J indwelling time,stone-free cases at postoperative 1 month,incidence of postoperative complications and hospitalization cost between two groups were not statistically significant(P>0.05).Conclusions:The effects of MPCNL and RLU in the treatment of complex ureteral calculi are good.The RLU is quick recovery and high stone-free,which is worthy of further clinical application.
2015, 40(12): 1678-1680,1683.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.021
Abstract:
Objective:To evaluate the safety and effectiveness of laparoscopic myomectomy combined with uterine artery occlusion in the treatment of uterine fibroids.Methods:Eighty uterine fibroids patients treated with laparoscopic myomectomy were divided into the joint uterine artery occlusion group(blocking group) and non-jiont uterine artery occlusion(control group).The intraoperative condition and postoperative recovery between two groups were compared.Results:All patients were cured and no conversion to open surgery.The operative time,intraoperative blood loss,stomach exhaust time,postoperative hospital stay and postoperative pain scores in blocking group were significantly less or better than those in control group(P<0.01).The differences of the IL-1,IL-6 and TNF-α levels before operation between two groups were not statistically significant(P>0.05),the IL-1,IL-6 and TNF-α levels after 3 days of operation in blocking group were significantly less than those in control group(P<0.01).During the period of following-up,the menorrhagia relieve rate in blocking group was higher than that in control group(P<0.05),but the menstrual volume and fibroid recurrence rate in blocking group were significantly lower than those in control group(P<0.01 and P<0.05).Conclusions:Patients treated with laparoscopic uterine artery occlusion is good toleration,less bleeding,little inflammatory and low recurrence rate during the period of following-up,which is worthy of application.
Objective:To evaluate the safety and effectiveness of laparoscopic myomectomy combined with uterine artery occlusion in the treatment of uterine fibroids.Methods:Eighty uterine fibroids patients treated with laparoscopic myomectomy were divided into the joint uterine artery occlusion group(blocking group) and non-jiont uterine artery occlusion(control group).The intraoperative condition and postoperative recovery between two groups were compared.Results:All patients were cured and no conversion to open surgery.The operative time,intraoperative blood loss,stomach exhaust time,postoperative hospital stay and postoperative pain scores in blocking group were significantly less or better than those in control group(P<0.01).The differences of the IL-1,IL-6 and TNF-α levels before operation between two groups were not statistically significant(P>0.05),the IL-1,IL-6 and TNF-α levels after 3 days of operation in blocking group were significantly less than those in control group(P<0.01).During the period of following-up,the menorrhagia relieve rate in blocking group was higher than that in control group(P<0.05),but the menstrual volume and fibroid recurrence rate in blocking group were significantly lower than those in control group(P<0.01 and P<0.05).Conclusions:Patients treated with laparoscopic uterine artery occlusion is good toleration,less bleeding,little inflammatory and low recurrence rate during the period of following-up,which is worthy of application.
2015, 40(12): 1681-1683.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.022
Abstract:
Objective:To investigate the relationship between the levels of COOH-terminus tensin-like molecule(CTEN) and recurrence,metastasis and prognosis of colorectal carcinoma patients after operation.Methods:The expression levels of CTEN in colorectal carcinoma tissue of 80 patients were detected using immunohistochemistry(IHC),and the relation of which with prognosis was analyzed.Results:The positive rates of CTEN in colorectal carcinoma tissue and paracarcinoma tissues were 83.8%(67/80) and 12.5%(10/80),respectively,the difference of which was statistical significance(P<0.05).The positive rates of CTEN in stages Ⅲ and Ⅳ patients were significantly higher than that in stages Ⅰ and Ⅱ patients(P<0.05).The positive rates of CTEN in recurrence and metastases patients after 3 years of operation were higher than that in no-recurrence and metastases patients(P<0.01).Kaplan-Meier survival analysis showed that the prognosis in no and low expression of CTEN patients were significantly better than that in high expression of CTEN patients(P<0.01).Conclusions:The expression of CTEN is correlation with the postoperative recurrence and metastases of patients with colorectal carcinoma,which may be an effective predictor in the prognosis of colorectal carcinoma.
Objective:To investigate the relationship between the levels of COOH-terminus tensin-like molecule(CTEN) and recurrence,metastasis and prognosis of colorectal carcinoma patients after operation.Methods:The expression levels of CTEN in colorectal carcinoma tissue of 80 patients were detected using immunohistochemistry(IHC),and the relation of which with prognosis was analyzed.Results:The positive rates of CTEN in colorectal carcinoma tissue and paracarcinoma tissues were 83.8%(67/80) and 12.5%(10/80),respectively,the difference of which was statistical significance(P<0.05).The positive rates of CTEN in stages Ⅲ and Ⅳ patients were significantly higher than that in stages Ⅰ and Ⅱ patients(P<0.05).The positive rates of CTEN in recurrence and metastases patients after 3 years of operation were higher than that in no-recurrence and metastases patients(P<0.01).Kaplan-Meier survival analysis showed that the prognosis in no and low expression of CTEN patients were significantly better than that in high expression of CTEN patients(P<0.01).Conclusions:The expression of CTEN is correlation with the postoperative recurrence and metastases of patients with colorectal carcinoma,which may be an effective predictor in the prognosis of colorectal carcinoma.
2015, 40(12): 1684-1686.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.023
Abstract:
Objective:To investigate the clinical effects of Fable and Oriental Story combined with normal medication in the treatment of neurosis patients.Methods:Sixty neurosis patients were randomly divided into the observation group and control group(30 cases each group).The control group were treated with normal medication,and the observation group were additionally treated with Fable and Oriental Story based on normal medication therapy for 10 weeks.Each factor score of the test results assessed by Symptom Check List 90(SCL-90) before and after the treatment between two groups were compared.Results:After 10 weeks of therapy,the differences of the phobic anxiety and psychoticism scores between two groups were not statistically significant(P>0.05),the decreasing degree of the rest factors scores of SCL-90 in observation group were higher than those in control group(P<0.05 to P<0.01).The daily use dosage of anti-anxiety and anti-depressant medication in observation group was significantly lower than that in control group(P<0.01).The overall incidence of adverse reactions in observation group(10.00%) was significantly lower than that in control group(46.67%)(P<0.01).Conclusions:The effects of Fable and Oriental Story combined with normal medication in the treatment of neurosis patients is better.
Objective:To investigate the clinical effects of Fable and Oriental Story combined with normal medication in the treatment of neurosis patients.Methods:Sixty neurosis patients were randomly divided into the observation group and control group(30 cases each group).The control group were treated with normal medication,and the observation group were additionally treated with Fable and Oriental Story based on normal medication therapy for 10 weeks.Each factor score of the test results assessed by Symptom Check List 90(SCL-90) before and after the treatment between two groups were compared.Results:After 10 weeks of therapy,the differences of the phobic anxiety and psychoticism scores between two groups were not statistically significant(P>0.05),the decreasing degree of the rest factors scores of SCL-90 in observation group were higher than those in control group(P<0.05 to P<0.01).The daily use dosage of anti-anxiety and anti-depressant medication in observation group was significantly lower than that in control group(P<0.01).The overall incidence of adverse reactions in observation group(10.00%) was significantly lower than that in control group(46.67%)(P<0.01).Conclusions:The effects of Fable and Oriental Story combined with normal medication in the treatment of neurosis patients is better.
2015, 40(12): 1687-1688.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.024
Abstract:
Objective:To investigate the effects of the vacuum sealing drainage(VSD) combined with upper gluteus maximus myocutaneous flap in the repair of the pressure ulcer with Ⅳ phase.Methods:The pressure ulcer with Ⅳ phase in sacral tail of 13 cases were treated with the primary phase debridement VSD technology combined with second upper gluteus maximus myocutaneous flap.The minimum and maximum wound were 5.5 cm×7 cm and 11 cm×15 cm,respectively.Results:All 13 myocutaneous flaps survived,part far edge of myocutaneous flaps necrosis in 2 cases were cured.All patients were followed up for 6 months to 3 years,the recurrence in 1 case caused by family condition and unrecurrence in 12 cases were found.Conclusions:The effect of the VSD combined with upper gluteus maximus myocutaneous flap in the repair of pressure ulcer with Ⅳ phase is good.
Objective:To investigate the effects of the vacuum sealing drainage(VSD) combined with upper gluteus maximus myocutaneous flap in the repair of the pressure ulcer with Ⅳ phase.Methods:The pressure ulcer with Ⅳ phase in sacral tail of 13 cases were treated with the primary phase debridement VSD technology combined with second upper gluteus maximus myocutaneous flap.The minimum and maximum wound were 5.5 cm×7 cm and 11 cm×15 cm,respectively.Results:All 13 myocutaneous flaps survived,part far edge of myocutaneous flaps necrosis in 2 cases were cured.All patients were followed up for 6 months to 3 years,the recurrence in 1 case caused by family condition and unrecurrence in 12 cases were found.Conclusions:The effect of the VSD combined with upper gluteus maximus myocutaneous flap in the repair of pressure ulcer with Ⅳ phase is good.
2015, 40(12): 1703-1705.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.032
Abstract:
Objective:To explore the clinical value of the joint detection of hepatitis B virus large protein(HBV-LP) and hepatitis B virus DNA(HBV-DNA) in antiviral therapy.Methods:Three hundred patients with hepatitis B were treated with antiviral therapy.The serum levels of HBV-LP and HBV-DNA in all patients were detected before treatment and after 6 and 12 months of treatment,the result of which was analyzed.Results:The difference of HBV-LP in different HBV-DNA copies patients was statistical significance(P<0.01).The HBV-LP content was positive correlation with HBV-DNA copies.The positive rates of HBV-LP,HBeAg and HBV DNA decreased with the time extension of treatment,and the differences of whose between before and after treatment were statistical significance(P<0.01).The positive rates of HBV-LP were higher than that of HBV-DNA after 6 and 12 months of treatment(P<0.01).With the time extension of antiviral treatment,the sensitivity,specificity and positive predictive value of HBV-LP decreased,increased and decreased,respectively.The sensitivity(93.28%) and specificity(53.01%) of HBV-LP were the lowest and highest after 12 months of treatment.Conclusions:The negative HBV-DNA does not mean the disappearance of intrahepatic HBV replication.The joint detection of HBV-LP and HBV-DNA can detect the virus replication,which has important clinical value in monitoring antiviral treatment.
Objective:To explore the clinical value of the joint detection of hepatitis B virus large protein(HBV-LP) and hepatitis B virus DNA(HBV-DNA) in antiviral therapy.Methods:Three hundred patients with hepatitis B were treated with antiviral therapy.The serum levels of HBV-LP and HBV-DNA in all patients were detected before treatment and after 6 and 12 months of treatment,the result of which was analyzed.Results:The difference of HBV-LP in different HBV-DNA copies patients was statistical significance(P<0.01).The HBV-LP content was positive correlation with HBV-DNA copies.The positive rates of HBV-LP,HBeAg and HBV DNA decreased with the time extension of treatment,and the differences of whose between before and after treatment were statistical significance(P<0.01).The positive rates of HBV-LP were higher than that of HBV-DNA after 6 and 12 months of treatment(P<0.01).With the time extension of antiviral treatment,the sensitivity,specificity and positive predictive value of HBV-LP decreased,increased and decreased,respectively.The sensitivity(93.28%) and specificity(53.01%) of HBV-LP were the lowest and highest after 12 months of treatment.Conclusions:The negative HBV-DNA does not mean the disappearance of intrahepatic HBV replication.The joint detection of HBV-LP and HBV-DNA can detect the virus replication,which has important clinical value in monitoring antiviral treatment.
2015, 40(12): 1708-1709.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.034
Abstract:
Objective:To explore the sonogram features of different types vaginal atresia to increase the ultrasound diagnosis rate and classification accuracy.Methods:The sonogram features of 19 patients with vaginal atresia(including 4 types) were retrospectively analyzed.Results:The ultrasound image found 10 cases of haematocolpos,16 cases of cervical hemorrhage,18 case hematometra and 1 case of large cystic masse in pelvic cavity.Conclusions:Ultrasound plays an important role in classification,diagnosis and differential diagnosis of vaginal atresia.
Objective:To explore the sonogram features of different types vaginal atresia to increase the ultrasound diagnosis rate and classification accuracy.Methods:The sonogram features of 19 patients with vaginal atresia(including 4 types) were retrospectively analyzed.Results:The ultrasound image found 10 cases of haematocolpos,16 cases of cervical hemorrhage,18 case hematometra and 1 case of large cystic masse in pelvic cavity.Conclusions:Ultrasound plays an important role in classification,diagnosis and differential diagnosis of vaginal atresia.
2015, 40(12): 1710-1712.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.035
Abstract:
Objective:To explore the ultrasonography value and clinical characteristics of schistosomal appendicitis.Methods:The clinical features and ultrasonographic signs in 41 schistosomal appendicitis cases diagnosed by pathology were retrospectively analyzed,whose were compared with 80 non-schistosomal appendicitis cases.Results:The age of schistosomal appendicitis patient was higher than that in non-schistosomal appendicitis patients(P<0.05).The canceration,perforation and suppuration rates in schistosomal appendicitis patients were higher than those in non-schistosomal appendicitis patients(P<0.01).The direct and indirect ultrasonographic signs in schistosomal appendicitis patients were more plentiful than those in non-schistosomal appendicitis patients(P<0.05 to P<0.01).Conclusions:The combination of ultrasonography and clinical characteristics can help the diagnosis and treatment of schistosomal appendicitis,which is beneficial to the operation and prognosis of patients.
Objective:To explore the ultrasonography value and clinical characteristics of schistosomal appendicitis.Methods:The clinical features and ultrasonographic signs in 41 schistosomal appendicitis cases diagnosed by pathology were retrospectively analyzed,whose were compared with 80 non-schistosomal appendicitis cases.Results:The age of schistosomal appendicitis patient was higher than that in non-schistosomal appendicitis patients(P<0.05).The canceration,perforation and suppuration rates in schistosomal appendicitis patients were higher than those in non-schistosomal appendicitis patients(P<0.01).The direct and indirect ultrasonographic signs in schistosomal appendicitis patients were more plentiful than those in non-schistosomal appendicitis patients(P<0.05 to P<0.01).Conclusions:The combination of ultrasonography and clinical characteristics can help the diagnosis and treatment of schistosomal appendicitis,which is beneficial to the operation and prognosis of patients.
2015, 40(12): 1715-1717,1720.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.037
Abstract:
Objective:To explore the psychological characteristics of the perioperative patients treated with endoscopic retrograde cholangiopancreatography(ERCP),evaluate the intervention effects of psychological nursing on the ERCP patients for providing scientific basis in formulating psychological nursing program.Methods:Fifty-eight patients treated with ERCP were randomly divided into the intervention group(30 cases) and control group(28 cases),and 24 healthy people were set as the healthy control group.The intervention group and control group were evaluated using the Hospital Anxiety and Depression Scale(HAD) and Pittsburgh Sleep quality index scale(PSQI) before and after operation,the bed time and hospital stay after ERCP between the intervention group and control group were compared.The psychological status of healthy control group were evaluated.Results:The preoperative anxiety and depression scores in intervention group and control group were higher than those in healthy control group(P<0.05 and P<0.01).Among the preoperative PSQI scores,the differences of the scores of hypnotic drugs and daytime dysfunction between the intervention group and control group were not statistically significant(P>0.05),and other item scores in intervention group and control group were higher than those in healthy control group(P<0.05 to P<0.01).The differences of the preoperative scores of HAD and PSQI between the intervention group and control group were not statistically significant(P>0.05).The postoperative anxiety and depression scores in intervention group were lower than those in control group(P<0.05 and P<0.01).Except the scores difference of hypnotic drugs and daytime dysfunction,other item scores differences of PSQI scores between the intervention group and control group were statistically significant(P<0.05 to P<0.01).The postoperative bed time and hospital stay in intervention group were shorter than those in control group(P<0.05).Conclusions:The anxiety,depression and sleep disturbance are the main perioperative manifestations.Psychological nursing can significantly improve the psychological stress,reduce bed time and hospitalization time of patients.
Objective:To explore the psychological characteristics of the perioperative patients treated with endoscopic retrograde cholangiopancreatography(ERCP),evaluate the intervention effects of psychological nursing on the ERCP patients for providing scientific basis in formulating psychological nursing program.Methods:Fifty-eight patients treated with ERCP were randomly divided into the intervention group(30 cases) and control group(28 cases),and 24 healthy people were set as the healthy control group.The intervention group and control group were evaluated using the Hospital Anxiety and Depression Scale(HAD) and Pittsburgh Sleep quality index scale(PSQI) before and after operation,the bed time and hospital stay after ERCP between the intervention group and control group were compared.The psychological status of healthy control group were evaluated.Results:The preoperative anxiety and depression scores in intervention group and control group were higher than those in healthy control group(P<0.05 and P<0.01).Among the preoperative PSQI scores,the differences of the scores of hypnotic drugs and daytime dysfunction between the intervention group and control group were not statistically significant(P>0.05),and other item scores in intervention group and control group were higher than those in healthy control group(P<0.05 to P<0.01).The differences of the preoperative scores of HAD and PSQI between the intervention group and control group were not statistically significant(P>0.05).The postoperative anxiety and depression scores in intervention group were lower than those in control group(P<0.05 and P<0.01).Except the scores difference of hypnotic drugs and daytime dysfunction,other item scores differences of PSQI scores between the intervention group and control group were statistically significant(P<0.05 to P<0.01).The postoperative bed time and hospital stay in intervention group were shorter than those in control group(P<0.05).Conclusions:The anxiety,depression and sleep disturbance are the main perioperative manifestations.Psychological nursing can significantly improve the psychological stress,reduce bed time and hospitalization time of patients.
2015, 40(12): 1718-1720.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.038
Abstract:
Objective:To explore the effects of labor ball combined with free position midwifery on the pain of childbirth and birth control.Methods:Sixty natural childbirth primiparas were randomly divided into the control group and observation group(30 cases each group) according to the digital table.The control group were treated with the supine or semi-recumbent position delivery,the observation group were treated with labor ball combined with free position midwifery.The pain of childbirth and birth control between two groups were compared.Results:The birth control score in observation group[(3.54±0.89)min] was significantly higher than that in control group[(6.47 ± 1.62)min](P<0.01).The visual analogue score,speech response score and present pain intensity score in observation group[(6.04±1.51),(19.13±4.79) and(2.64±0.67) points] were significantly lower than those in control group[(8.69±2.18),(28.57±7.15)and(3.98±1.00) points],respectively(P<0.01).Conclusions:The labor ball combined with free position midwifery can alleviate the delivery pain,improve the birth control and promote the successful completion of delivery.
Objective:To explore the effects of labor ball combined with free position midwifery on the pain of childbirth and birth control.Methods:Sixty natural childbirth primiparas were randomly divided into the control group and observation group(30 cases each group) according to the digital table.The control group were treated with the supine or semi-recumbent position delivery,the observation group were treated with labor ball combined with free position midwifery.The pain of childbirth and birth control between two groups were compared.Results:The birth control score in observation group[(3.54±0.89)min] was significantly higher than that in control group[(6.47 ± 1.62)min](P<0.01).The visual analogue score,speech response score and present pain intensity score in observation group[(6.04±1.51),(19.13±4.79) and(2.64±0.67) points] were significantly lower than those in control group[(8.69±2.18),(28.57±7.15)and(3.98±1.00) points],respectively(P<0.01).Conclusions:The labor ball combined with free position midwifery can alleviate the delivery pain,improve the birth control and promote the successful completion of delivery.
2015, 40(12): 1721-1722.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.039
Abstract:
Objective:To investigate the effects of positive nursing intervention on the clinical efficacy of children with pneumonia.Methods:One hundred and ten children with pneumonia were randomly divided into the observation group and control group(55 cases each group).The observation group and control group were treated with routine nursing intervention and positive nursing intervention,respectively.The lung function index,symptoms disappearing time and quality of life between two groups after nursing intervention were compared.Results:After nursing intervention,the lung function index in observation group was significantly lower than that in control group(P<0.01),the disappearance time of asthma,cough and pulmonary symptoms in observation group were significantly shorter than those in control group(P<0.01),and the live and body scores in observation group were significantly shorter than those in control group(P<0.01).Conclusions:The positive nursing intervention on children with pneumonia can significantly improve their lung function,shorten the symptoms disappearance time and enhance quality of life,which is worthy of clinical application.
Objective:To investigate the effects of positive nursing intervention on the clinical efficacy of children with pneumonia.Methods:One hundred and ten children with pneumonia were randomly divided into the observation group and control group(55 cases each group).The observation group and control group were treated with routine nursing intervention and positive nursing intervention,respectively.The lung function index,symptoms disappearing time and quality of life between two groups after nursing intervention were compared.Results:After nursing intervention,the lung function index in observation group was significantly lower than that in control group(P<0.01),the disappearance time of asthma,cough and pulmonary symptoms in observation group were significantly shorter than those in control group(P<0.01),and the live and body scores in observation group were significantly shorter than those in control group(P<0.01).Conclusions:The positive nursing intervention on children with pneumonia can significantly improve their lung function,shorten the symptoms disappearance time and enhance quality of life,which is worthy of clinical application.
2015, 40(12): 1723-1725.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.040
Abstract:
Objective:To compare the oral care,replacing fixed material and fixation effects between the one-time tracheal intubation fixer and dental pad white inch band fixation method in ventilator intubation via mouth.Methods:Seventy patients with ventilator intubation via mouth were randomly divided into the experimental group and control group(35 cases each group).The experimental group and control group were treated with the one-time tracheal intubation fixer and dental pad white inch band fixation method,respectively.The oral care,replacing fixed material and fixation effects(including the injury and slip of intubation,and observation of the intubation scale within 1 week) between two groups were compared.Results:Compared with the control group,the operation was simple,the oral care and replacement of fixed materials were convenient and short time,the fixed effect was reliable,and the observation of the scale was convenient and easy in the experimental group.Conclusions:The one-time tracheal intubation fixer is worthy of clinical use.
Objective:To compare the oral care,replacing fixed material and fixation effects between the one-time tracheal intubation fixer and dental pad white inch band fixation method in ventilator intubation via mouth.Methods:Seventy patients with ventilator intubation via mouth were randomly divided into the experimental group and control group(35 cases each group).The experimental group and control group were treated with the one-time tracheal intubation fixer and dental pad white inch band fixation method,respectively.The oral care,replacing fixed material and fixation effects(including the injury and slip of intubation,and observation of the intubation scale within 1 week) between two groups were compared.Results:Compared with the control group,the operation was simple,the oral care and replacement of fixed materials were convenient and short time,the fixed effect was reliable,and the observation of the scale was convenient and easy in the experimental group.Conclusions:The one-time tracheal intubation fixer is worthy of clinical use.
2015, 40(12): 1726-1728.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.041
Abstract:
Objective:To observe the curative effects of comprehensive traditional Chinese medicine nursing on patients with deficient vital energy and blood stasis after stroke.Methods:Ninety-six hospitalized patients with post-stroke deficiency of vital energy and blood stasis were randomly divided into treatment group and control group.The patients in the control group received the routine nursing according to the nursing plan delivered by Beijing Bureau of traditional Chinese medicine,while the patients in the treatment group were given comprehensive traditional Chinese medicine nursing including food nursing,moxa-wool moxibustion nursing,traditional Chinese medicine foam washing and hot compress.The Fugl-Meyer movement function marking and Barthel index of the two groups were observed before treatment and 42 days after treatment.Results:The Fugl-Meyer movement function marking and Barthel index of both groups improved significantly(P<0.01),and the observation group was superior to the control group(P<0.01).Conclusions:Comprehensive nursing with traditional Chinese medicine may improve the daily movement function and life ability of the patients with deficient vital energy and blood stasis after stoke.
Objective:To observe the curative effects of comprehensive traditional Chinese medicine nursing on patients with deficient vital energy and blood stasis after stroke.Methods:Ninety-six hospitalized patients with post-stroke deficiency of vital energy and blood stasis were randomly divided into treatment group and control group.The patients in the control group received the routine nursing according to the nursing plan delivered by Beijing Bureau of traditional Chinese medicine,while the patients in the treatment group were given comprehensive traditional Chinese medicine nursing including food nursing,moxa-wool moxibustion nursing,traditional Chinese medicine foam washing and hot compress.The Fugl-Meyer movement function marking and Barthel index of the two groups were observed before treatment and 42 days after treatment.Results:The Fugl-Meyer movement function marking and Barthel index of both groups improved significantly(P<0.01),and the observation group was superior to the control group(P<0.01).Conclusions:Comprehensive nursing with traditional Chinese medicine may improve the daily movement function and life ability of the patients with deficient vital energy and blood stasis after stoke.
2015, 40(12): 1729-1732.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.042
Abstract:
Objective:To investigate the influencing factors of the sleep disorder in elderly hypertensive patients and its nursing countermeasures.Methods:The influencing factors of the sleep disorder in 80 elderly hypertensive patients were retrospectively analyzed.The sleep quality of patients was evaluated by Pittsburgh sleep quality index(PSQI),the patients with sleep disorder were treated with nursing intervention.The changes of sleep and blood pressure in sleep disorders patients were compared before and after the treatment.Results:The psychological anxiety and environment were the critical factors of sleep disorder in elderly hypertensive patients.After nursing intervention,the PQSI scores and blood pressure of patients were significantly lower than those in the patients at admission(P<0.01),and the PQSI scores of patients were significantly lower than that in control group(P<0.01).Conclusions:The psychological anxiety and environment are the main reasons of sleep disorder in elderly hypertensive patients.Only decreasing blood pressure treatment can decrease the PQSI score of sleep disorder patients,but the reasonable nursing intervention can significantly improve the sleep quality and effects of antihypertensive therapy of patients.
Objective:To investigate the influencing factors of the sleep disorder in elderly hypertensive patients and its nursing countermeasures.Methods:The influencing factors of the sleep disorder in 80 elderly hypertensive patients were retrospectively analyzed.The sleep quality of patients was evaluated by Pittsburgh sleep quality index(PSQI),the patients with sleep disorder were treated with nursing intervention.The changes of sleep and blood pressure in sleep disorders patients were compared before and after the treatment.Results:The psychological anxiety and environment were the critical factors of sleep disorder in elderly hypertensive patients.After nursing intervention,the PQSI scores and blood pressure of patients were significantly lower than those in the patients at admission(P<0.01),and the PQSI scores of patients were significantly lower than that in control group(P<0.01).Conclusions:The psychological anxiety and environment are the main reasons of sleep disorder in elderly hypertensive patients.Only decreasing blood pressure treatment can decrease the PQSI score of sleep disorder patients,but the reasonable nursing intervention can significantly improve the sleep quality and effects of antihypertensive therapy of patients.
2015, 40(12): 1734-1738.
doi: 10.13898/j.cnki.issn.1000-2200.2015.12.044
Abstract:
Objective:To investigate the effects of continuity nursing on self-care ability and mental state of patients with coronary heart disease after percutaneous coronary intervention.Methods:Five hundred and six patients with coronary heart disease after PCI were randomly divided into observation group and control group,253 cases in each.The control group patients were given routine nursing,the observation group patients were given continuity nursing on this basis.The rehabilitation knowledge,the self-care ability,the risk factors control compliance,the mental state and the life quality was compared between the two groups.Results:After nursing intervention 3,6 and 12 months,the rehabilitation knowledge score and the self-care ability score of the observation group patients were evidently higher than that in control group(P<0.01).After nursing intervention 3,6 and 12 months,the compliance rates of the exercise,the low density lipoprotein,the quit smoking,the fasting blood glucose and the blood pressure control of the observation group patients were markedly higher than that in control group(P<0.01).After nursing intervention 3,6 and 12 months,the anxiety score in the observation group patients was obviously lower than that of control group(P<0.01).After nursing intervention 12 months,The score of each dimension in life quality in the observation group patients was observably higher than that of control group(P<0.01).After nursing intervention 12 months,the diastolic blood pressure,the systolic blood pressure,the low density lipoprotein cholesterol,the triglyceride and the total cholesterol in the observation group patients were clearly lower than that of control group(P<0.01).Conclusions:The continuity nursing can effectually improve the self-care ability,the mental state and the life quality of patients with coronary heart disease after PCI.
Objective:To investigate the effects of continuity nursing on self-care ability and mental state of patients with coronary heart disease after percutaneous coronary intervention.Methods:Five hundred and six patients with coronary heart disease after PCI were randomly divided into observation group and control group,253 cases in each.The control group patients were given routine nursing,the observation group patients were given continuity nursing on this basis.The rehabilitation knowledge,the self-care ability,the risk factors control compliance,the mental state and the life quality was compared between the two groups.Results:After nursing intervention 3,6 and 12 months,the rehabilitation knowledge score and the self-care ability score of the observation group patients were evidently higher than that in control group(P<0.01).After nursing intervention 3,6 and 12 months,the compliance rates of the exercise,the low density lipoprotein,the quit smoking,the fasting blood glucose and the blood pressure control of the observation group patients were markedly higher than that in control group(P<0.01).After nursing intervention 3,6 and 12 months,the anxiety score in the observation group patients was obviously lower than that of control group(P<0.01).After nursing intervention 12 months,The score of each dimension in life quality in the observation group patients was observably higher than that of control group(P<0.01).After nursing intervention 12 months,the diastolic blood pressure,the systolic blood pressure,the low density lipoprotein cholesterol,the triglyceride and the total cholesterol in the observation group patients were clearly lower than that of control group(P<0.01).Conclusions:The continuity nursing can effectually improve the self-care ability,the mental state and the life quality of patients with coronary heart disease after PCI.
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