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2016 Vol. 41, No. 8
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2016, 41(8): 981-984.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.001
Abstract:
Objective: To investigate the effects and clinical value of acellular dermal matrix(ADM) reconstructed with autologous platelet-rich plasma(PRP) combined with bone marrow stem cells(BMSCs) in the repair of cartilage of rabbit.Methods: Sixty rabbits with femoral condylar articular injury were randomly divided into the study group,control group and blank group(20 rabbits each group).The PRP and BMSCs were isolated,cultured,and inoculated with the ADM scaffolds in vitro.The 10% of PRP was added to the culture medium in study group,and the other treatment was the same as the control group.The blank group did not give any process.The BMSCs-ADM composite was implanted into the articular defect of rabbits.The reconstructing cartilage tissue was detected using the immune mechanics,histology and biomechanics at the end of 1,2 and 3 months of implantion.The restoration effects of joints defect with PRP-BMSCs-ADM were analyzed.Results: With the prolongation of the culture time,the number of BMSCs cells increased significantly,the growth curve of cells appeared S-shaped,which arrived at logarithmic phase and plateau phase after 3th day and 9th day,respectively.From the 3th day,the OD value of cell counts in study group was significantly higher than that in control group(P<0.01).With the extension of time,the number of cartilage-like cells in all groups increased,the cartilage space matured gradually,the surface of cartilage smoothed gradually,the macro scoring of IRCS and histological scoring increased significantly(P<0.01),the elastic modulus of the specimens pressure increased(P<0.05).During the same period,the specimen scoring and pressure elastic modulus in study group were significantly higher than those in control group and blank group(P<0.01).After 3 months,the repair of cartilage defect in study group was significantly better than that in control group and blank group(P<0.01).Conclusions: The effects of ADM reconstructed with PRP combined with BMSCs in repairing the cartilage of rabbit are good,which is feasible.
Objective: To investigate the effects and clinical value of acellular dermal matrix(ADM) reconstructed with autologous platelet-rich plasma(PRP) combined with bone marrow stem cells(BMSCs) in the repair of cartilage of rabbit.Methods: Sixty rabbits with femoral condylar articular injury were randomly divided into the study group,control group and blank group(20 rabbits each group).The PRP and BMSCs were isolated,cultured,and inoculated with the ADM scaffolds in vitro.The 10% of PRP was added to the culture medium in study group,and the other treatment was the same as the control group.The blank group did not give any process.The BMSCs-ADM composite was implanted into the articular defect of rabbits.The reconstructing cartilage tissue was detected using the immune mechanics,histology and biomechanics at the end of 1,2 and 3 months of implantion.The restoration effects of joints defect with PRP-BMSCs-ADM were analyzed.Results: With the prolongation of the culture time,the number of BMSCs cells increased significantly,the growth curve of cells appeared S-shaped,which arrived at logarithmic phase and plateau phase after 3th day and 9th day,respectively.From the 3th day,the OD value of cell counts in study group was significantly higher than that in control group(P<0.01).With the extension of time,the number of cartilage-like cells in all groups increased,the cartilage space matured gradually,the surface of cartilage smoothed gradually,the macro scoring of IRCS and histological scoring increased significantly(P<0.01),the elastic modulus of the specimens pressure increased(P<0.05).During the same period,the specimen scoring and pressure elastic modulus in study group were significantly higher than those in control group and blank group(P<0.01).After 3 months,the repair of cartilage defect in study group was significantly better than that in control group and blank group(P<0.01).Conclusions: The effects of ADM reconstructed with PRP combined with BMSCs in repairing the cartilage of rabbit are good,which is feasible.
2016, 41(8): 985-987,991.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.002
Abstract:
Objective: To explore the viability,migration and differentiation of human umbilical cord blood mesenchymal stem cells(MSCs) in brain of rats with cerebral palsy(CP) after the lateral ventricle injection.Methods: Fourteen CP model rats were established by the intraperitoneal injection of lipopolysaccharide,and the labeled MSCs were injected into the lateral ventricle in 12 CP rats.The viability,migration and differentiation of MSCs in rat brain were observed after 1 to 4 weeks of injection.Other two rats without injecting were set as the control group.Results: The CP model rats were successfully established by the intraperitoneal injection of lipopolysaccharide,and the MSCs were identified.The colonizing MSCs could survive,migrate and differentiate into neurons,and which decreased with the transplanting time extending(P<0.01).The positive MSCs was not explored in two rats without the MSCs injecting.Conclusions: MSCs can survive in brain of rats with CP,and the number of which decrease with the time extending.
Objective: To explore the viability,migration and differentiation of human umbilical cord blood mesenchymal stem cells(MSCs) in brain of rats with cerebral palsy(CP) after the lateral ventricle injection.Methods: Fourteen CP model rats were established by the intraperitoneal injection of lipopolysaccharide,and the labeled MSCs were injected into the lateral ventricle in 12 CP rats.The viability,migration and differentiation of MSCs in rat brain were observed after 1 to 4 weeks of injection.Other two rats without injecting were set as the control group.Results: The CP model rats were successfully established by the intraperitoneal injection of lipopolysaccharide,and the MSCs were identified.The colonizing MSCs could survive,migrate and differentiate into neurons,and which decreased with the transplanting time extending(P<0.01).The positive MSCs was not explored in two rats without the MSCs injecting.Conclusions: MSCs can survive in brain of rats with CP,and the number of which decrease with the time extending.
2016, 41(8): 988-991.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.003
Abstract:
Objective: To observe the effects of sevoflurane post-processing on the relative index of myocardial enzyme in patients treated with heart valve replacement under cardiopulmonary bypass(CPB).Methods: Seventy-two rheumatic heart disease patients treated with heart valve replacement under CPB were randomly divided into the sevoflurane post-processing group(group S) and control group(group C)(36 cases each group).The group S were treated with the 2% of sevoflurane by cardiopulmonary bypass into blood circulation for 15 minutes at the time of aorta opening,the group C were treated with intravenous anesthesia.The jugular venous blood was collected before anesthesia induction(T0),after 30 min(T1),3h(T2) and 24h(T3) of aorta opening,and centrifuged for 10min,the supernatant of which was stored at -20℃.The serum levels of cardiac troponin(cTnI),creatine kinase(CK),creatine kinase(CK-MB) and lactate dehydrogenase(LDH) were meaured and compared at four time points.Results: Compared at T0,the levels of cTnI,CK,CK-MB and LDH in two groups significantly increased at T1,T2 and T3(P<0.01).The levels of cTnI at T3,CK at T2 and T3,CK-MB at T1 and LDH at T1,T2 and T3 in group S were significantly lower than those in group C(P<0.01 and P<0.05).The differences of gerenal condition and total amount of dopamine using between two groups were not statistically significant(P>0.05).Conclusions: Sevoflurane post-processing can reduce the myocardial enzyme releasing in patients treated with heart valve replacement under cardiopulmonary bypass,alleviate the injury of myocardial ischemia-reperfusion and protect the myocardum.
Objective: To observe the effects of sevoflurane post-processing on the relative index of myocardial enzyme in patients treated with heart valve replacement under cardiopulmonary bypass(CPB).Methods: Seventy-two rheumatic heart disease patients treated with heart valve replacement under CPB were randomly divided into the sevoflurane post-processing group(group S) and control group(group C)(36 cases each group).The group S were treated with the 2% of sevoflurane by cardiopulmonary bypass into blood circulation for 15 minutes at the time of aorta opening,the group C were treated with intravenous anesthesia.The jugular venous blood was collected before anesthesia induction(T0),after 30 min(T1),3h(T2) and 24h(T3) of aorta opening,and centrifuged for 10min,the supernatant of which was stored at -20℃.The serum levels of cardiac troponin(cTnI),creatine kinase(CK),creatine kinase(CK-MB) and lactate dehydrogenase(LDH) were meaured and compared at four time points.Results: Compared at T0,the levels of cTnI,CK,CK-MB and LDH in two groups significantly increased at T1,T2 and T3(P<0.01).The levels of cTnI at T3,CK at T2 and T3,CK-MB at T1 and LDH at T1,T2 and T3 in group S were significantly lower than those in group C(P<0.01 and P<0.05).The differences of gerenal condition and total amount of dopamine using between two groups were not statistically significant(P>0.05).Conclusions: Sevoflurane post-processing can reduce the myocardial enzyme releasing in patients treated with heart valve replacement under cardiopulmonary bypass,alleviate the injury of myocardial ischemia-reperfusion and protect the myocardum.
2016, 41(8): 992-994,999.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.004
Abstract:
Objective: To observe the clinical efficacy and safety of the percutaneous catheter drainage(PCD) in the treatment of the peripancreatic or peritoneal effusion in the early phase of severe acute pancreatitis.Methods: The peripancreatic or peritoneal effusion in the early phase of severe acute pancreatitis in 37 patients were treated with PCD guided by ultrasound or CT.The clinical symptoms,clinical and laboratory indicators between before puncture and after 3 days of puncture,and the postoperative complications in all cases were compared.Results: Compared before treatment,the clinical symptoms,and the scores of clinical and biochemical indexes,intra-abdominal pressure,acute physiology and chronic health conditions and multiple organ dysfunction syndrome were significantly improved after 3 days of puncture(P<0.05 to P<0.01).The puncture injury in 3 cases(8.1%),drainage catheter obstruction in 2 cases(5.4%),catheter translocation in 3 cases(8.1%) and catheter off in 1 case(2.7%) were found.No serious complications(including bowel and abdominal visceral injury) in all cases were identified.Conclusions: The treatment of the peripancreatic or peritoneal effusion in the early phase of severe acute pancreatitis with PCD can improve the clinical symptoms,clinical and laboratory indicators,and relieve the intra-abdominal pressure of patients.
Objective: To observe the clinical efficacy and safety of the percutaneous catheter drainage(PCD) in the treatment of the peripancreatic or peritoneal effusion in the early phase of severe acute pancreatitis.Methods: The peripancreatic or peritoneal effusion in the early phase of severe acute pancreatitis in 37 patients were treated with PCD guided by ultrasound or CT.The clinical symptoms,clinical and laboratory indicators between before puncture and after 3 days of puncture,and the postoperative complications in all cases were compared.Results: Compared before treatment,the clinical symptoms,and the scores of clinical and biochemical indexes,intra-abdominal pressure,acute physiology and chronic health conditions and multiple organ dysfunction syndrome were significantly improved after 3 days of puncture(P<0.05 to P<0.01).The puncture injury in 3 cases(8.1%),drainage catheter obstruction in 2 cases(5.4%),catheter translocation in 3 cases(8.1%) and catheter off in 1 case(2.7%) were found.No serious complications(including bowel and abdominal visceral injury) in all cases were identified.Conclusions: The treatment of the peripancreatic or peritoneal effusion in the early phase of severe acute pancreatitis with PCD can improve the clinical symptoms,clinical and laboratory indicators,and relieve the intra-abdominal pressure of patients.
2016, 41(8): 995-999.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.005
Abstract:
Objective: To explore the levels of plasmacytoid dendritic cells(pDC) and interferon-α(INF-α) in peripheral blood of patients with systemic lupus erythematosus(SLE),and its significance.Methods: Sixty patients with SLE and 30 healthy people were divided into the SLE group and control group,respectively.The relative amounts of pDC in two groups were measured by flow cytometry,and the serum levels of INF-α was detected by enzyme linked immunosorbent assay.Results: The relative amount of pDC in peripheral blood of patients with SLE was significantly lower than that in control groups(P<0.01).The relative amounts of pDC in peripheral blood in patients with active SLE was significantly lower than that in patients with stable SLE(P<0.01).The relative amount of pDC in peripheral blood in SLE patients with positive anti-dsDNA antibody was lower than that in SLE patients with negative anti-dsDNA antibody(P<0.01).The relative amount of pDC in peripheral blood in SLE patients was significantly negative correlation with the quantification of dsDNA and ANA(P<0.01).The differences of anti-P0 antibody,anti-U1RNP antibody,anti-Smith antibody,anti-histone antibody,anti-nucleosome antibody,anti-SSA/Ro60 antibody,anti-SSA/Ro52 antibody and anti-SSB antibody between positive group and negative group were not statistically significant(P>0.05).The relative amount of pDC in peripheral blood in SLE patients with positive renal lesion was lower that in SLE patients with negative renal lesion(P<0.01).The relative amount of pDC in peripheral blood in SLE patients with positive hematologic damage was lower that in SLE patients with negative hematologic lesion(P<0.01).The differences of malar erythema,hypersensitivity to light,oral ulcersor and arthritis between positive group and negative group were not statistically significant(P>0.05).The relative amount of pDC in peripheral blood in SLE patients was correlation without erythrocyte sedimentation rate,C-reactive protein and immunoglobulin G and immunoglobulin,C3,C4 and activity scores of SLE(P>0.05).The serum level of IFN-α in patients with SLE was significantly higher than that in control group(P<0.01).Conclusions: The relative count of pDC in peripheral blood of SLE patients significantly decreases,which is correlation with disease,and a reference in clinical judgment of SLE disease activity.
Objective: To explore the levels of plasmacytoid dendritic cells(pDC) and interferon-α(INF-α) in peripheral blood of patients with systemic lupus erythematosus(SLE),and its significance.Methods: Sixty patients with SLE and 30 healthy people were divided into the SLE group and control group,respectively.The relative amounts of pDC in two groups were measured by flow cytometry,and the serum levels of INF-α was detected by enzyme linked immunosorbent assay.Results: The relative amount of pDC in peripheral blood of patients with SLE was significantly lower than that in control groups(P<0.01).The relative amounts of pDC in peripheral blood in patients with active SLE was significantly lower than that in patients with stable SLE(P<0.01).The relative amount of pDC in peripheral blood in SLE patients with positive anti-dsDNA antibody was lower than that in SLE patients with negative anti-dsDNA antibody(P<0.01).The relative amount of pDC in peripheral blood in SLE patients was significantly negative correlation with the quantification of dsDNA and ANA(P<0.01).The differences of anti-P0 antibody,anti-U1RNP antibody,anti-Smith antibody,anti-histone antibody,anti-nucleosome antibody,anti-SSA/Ro60 antibody,anti-SSA/Ro52 antibody and anti-SSB antibody between positive group and negative group were not statistically significant(P>0.05).The relative amount of pDC in peripheral blood in SLE patients with positive renal lesion was lower that in SLE patients with negative renal lesion(P<0.01).The relative amount of pDC in peripheral blood in SLE patients with positive hematologic damage was lower that in SLE patients with negative hematologic lesion(P<0.01).The differences of malar erythema,hypersensitivity to light,oral ulcersor and arthritis between positive group and negative group were not statistically significant(P>0.05).The relative amount of pDC in peripheral blood in SLE patients was correlation without erythrocyte sedimentation rate,C-reactive protein and immunoglobulin G and immunoglobulin,C3,C4 and activity scores of SLE(P>0.05).The serum level of IFN-α in patients with SLE was significantly higher than that in control group(P<0.01).Conclusions: The relative count of pDC in peripheral blood of SLE patients significantly decreases,which is correlation with disease,and a reference in clinical judgment of SLE disease activity.
2016, 41(8): 1000-1002.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.006
Abstract:
Objective: To compare the antiviral effects and adverse reactions between telbivudine and entecavirin in the chemotherapy of patients with non-Hodgkin lymphoma(NHL) complicated with hepatitis B virus(HBV) infection.Methods: The levels of HBV DNA in 50 patients with NHL complicated with HBV were from 2×103 to 2×104 IU/mL before chemotherapy.The patients were treated with cytoxan,hydroxyrubicin,oncovin and prednisone(CHOP) combined with telbivudine(600 mg/d) or entecavir(500 mg/d) for 6 cycles.The rates of reactivation of HBV replication,virological breakthrough related-hepatitis flare,primary drug nonresponse,liver failure and adverse reaction between 2 kinds of antiviral drugs treatment were compared.Results: Mild adverse events in two groups were found,the difference of which was not statistically significant(P>0.05).The primary drug nonresponse and liver failure in two groups were not found.The differences of the reactivation of HBV replication and hepatitis flare between two groups after 2 and 4 cycles of chemotherapy were not statistically significant(P>0.05).After 6 cycles of chemotherapy,the incidences of reactivation of HBV replication and hepatitis flare in the patients treated with telbivudine and entecavir were 28.0% & 32.0% and 4.0% & 8.0%,respectively.The difference of the incidence of hepatitis flare between two groups were statistically significant(P<0.05).Conclusions: The effects of telbivudine and entecavir in preventing liver failure and primary drug nonresponse in NHL complicated with HBV patients with 2×103 to 2×104 IU/mL of HBV DNA before treatment are good and safe.The hepatitis flare rate in patients treated with telbivudine is higher than that in patients treated with entecavir.
Objective: To compare the antiviral effects and adverse reactions between telbivudine and entecavirin in the chemotherapy of patients with non-Hodgkin lymphoma(NHL) complicated with hepatitis B virus(HBV) infection.Methods: The levels of HBV DNA in 50 patients with NHL complicated with HBV were from 2×103 to 2×104 IU/mL before chemotherapy.The patients were treated with cytoxan,hydroxyrubicin,oncovin and prednisone(CHOP) combined with telbivudine(600 mg/d) or entecavir(500 mg/d) for 6 cycles.The rates of reactivation of HBV replication,virological breakthrough related-hepatitis flare,primary drug nonresponse,liver failure and adverse reaction between 2 kinds of antiviral drugs treatment were compared.Results: Mild adverse events in two groups were found,the difference of which was not statistically significant(P>0.05).The primary drug nonresponse and liver failure in two groups were not found.The differences of the reactivation of HBV replication and hepatitis flare between two groups after 2 and 4 cycles of chemotherapy were not statistically significant(P>0.05).After 6 cycles of chemotherapy,the incidences of reactivation of HBV replication and hepatitis flare in the patients treated with telbivudine and entecavir were 28.0% & 32.0% and 4.0% & 8.0%,respectively.The difference of the incidence of hepatitis flare between two groups were statistically significant(P<0.05).Conclusions: The effects of telbivudine and entecavir in preventing liver failure and primary drug nonresponse in NHL complicated with HBV patients with 2×103 to 2×104 IU/mL of HBV DNA before treatment are good and safe.The hepatitis flare rate in patients treated with telbivudine is higher than that in patients treated with entecavir.
2016, 41(8): 1003-1006.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.007
Abstract:
Objective: To investigate the clinical value of the backward ureteral perfusing ice water combined with perirenal ice water cooling in the protection of renal function during the retroperitoneal laparoscopic nephron sparing surgery(RLNSS).Methods: Sixteen patients were treated with the RLNSS under the protection of the backward ureteral perfusing ice water combined with perirenal ice water cooling.Eleven cases with kidney cancer were treated with partial nephrectomy,and 5 cases with renal angiomyolipoma were treated with tumor enucleation.The F6 ureteral catheter was inserted into the ipsilateral ureter of patient with lithotomy position before operation.The retroperitoneal cavity of patient with lateral position was established using 4-hole method.The aspirator was placed into the fourth hole,which was used to perirenal ice water cooling through sucking out ice saline water during operation.The RLNSS was implemented under the condition of the backward ureteral perfusing ice water combined with perirenal ice water cooling,and the renal artery was blocked during the operation.Results: The RLNSS in 16 patients were successfully completed under the protection of low temperature.The average operation time,renal artery blocking time and blood loss were 95(85 to 160)min,42(29 to 55) min and 80(60 to 150) mL,respectively.The average decreasing temperature degree in skin,kidney surface and tumor surface were 0.8℃,11.5℃ and 10.2℃,respectively.Compared before operation,the proportion of the glomerular filtration rate(GFR) in total GFR decreased significantly after 2 weeks and 3 months of operation(P<0.01),but the difference of the proportion of GFR in total GFR between between 2 weeks and 3 months after operation was not statistical significance(P>0.05),and the further renal function damage was not found.Conclusions: The clinical effect of the backward ureteral perfusing ice water combined with perirenal ice water cooling during RLNSS is good,which can effectively prolong the renal ischemia time and protect the renal function,especially for patients with solitary kidney or long renal artery blocking time.
Objective: To investigate the clinical value of the backward ureteral perfusing ice water combined with perirenal ice water cooling in the protection of renal function during the retroperitoneal laparoscopic nephron sparing surgery(RLNSS).Methods: Sixteen patients were treated with the RLNSS under the protection of the backward ureteral perfusing ice water combined with perirenal ice water cooling.Eleven cases with kidney cancer were treated with partial nephrectomy,and 5 cases with renal angiomyolipoma were treated with tumor enucleation.The F6 ureteral catheter was inserted into the ipsilateral ureter of patient with lithotomy position before operation.The retroperitoneal cavity of patient with lateral position was established using 4-hole method.The aspirator was placed into the fourth hole,which was used to perirenal ice water cooling through sucking out ice saline water during operation.The RLNSS was implemented under the condition of the backward ureteral perfusing ice water combined with perirenal ice water cooling,and the renal artery was blocked during the operation.Results: The RLNSS in 16 patients were successfully completed under the protection of low temperature.The average operation time,renal artery blocking time and blood loss were 95(85 to 160)min,42(29 to 55) min and 80(60 to 150) mL,respectively.The average decreasing temperature degree in skin,kidney surface and tumor surface were 0.8℃,11.5℃ and 10.2℃,respectively.Compared before operation,the proportion of the glomerular filtration rate(GFR) in total GFR decreased significantly after 2 weeks and 3 months of operation(P<0.01),but the difference of the proportion of GFR in total GFR between between 2 weeks and 3 months after operation was not statistical significance(P>0.05),and the further renal function damage was not found.Conclusions: The clinical effect of the backward ureteral perfusing ice water combined with perirenal ice water cooling during RLNSS is good,which can effectively prolong the renal ischemia time and protect the renal function,especially for patients with solitary kidney or long renal artery blocking time.
2016, 41(8): 1006-1008.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.008
Abstract:
Objective: To compare the short-term effects between eccentric rotational acetabular osteotomy and Chiari osteotomy in the treatment of acetabular dysplasia.Methods: Thirty-four adults with acetabular dysplasia were randomly divided into the control group(18 cases) and observation group(16 cases).The control group and observation group were treated with Chiari osteotomy and eccentric rotational acetabular osteotomy,respectively.The operative time,blood loss,incision length,JOA score,CE angle,Sharp angle and postoperative complications between two groups were compared.Results: The differences of the operative time,blood loss and incision length between two groups were not statistically significant(P>0.05).The differences of the preoperative JOA score,CE and Sharp angle between two groups were not statistically significant(P>0.05).The postoperative JOA score and CE angle in observation group were significantly higher than those in control group(P<0.01),but for the Sharp angle,it was significantly lower than that in control group(P<0.01).The difference of the complications between two groups was not statistically significant(P=1.000).Conclusions: The short-term effect of eccentric rotational acetabular osteotomy in the treatment of acetabular dysplasia is better,which has certain clinical application value.
Objective: To compare the short-term effects between eccentric rotational acetabular osteotomy and Chiari osteotomy in the treatment of acetabular dysplasia.Methods: Thirty-four adults with acetabular dysplasia were randomly divided into the control group(18 cases) and observation group(16 cases).The control group and observation group were treated with Chiari osteotomy and eccentric rotational acetabular osteotomy,respectively.The operative time,blood loss,incision length,JOA score,CE angle,Sharp angle and postoperative complications between two groups were compared.Results: The differences of the operative time,blood loss and incision length between two groups were not statistically significant(P>0.05).The differences of the preoperative JOA score,CE and Sharp angle between two groups were not statistically significant(P>0.05).The postoperative JOA score and CE angle in observation group were significantly higher than those in control group(P<0.01),but for the Sharp angle,it was significantly lower than that in control group(P<0.01).The difference of the complications between two groups was not statistically significant(P=1.000).Conclusions: The short-term effect of eccentric rotational acetabular osteotomy in the treatment of acetabular dysplasia is better,which has certain clinical application value.
2016, 41(8): 1009-1011.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.009
Abstract:
Objective: To observe the effects of two different doses of naloxone on Bispectral index(BIS) in patients with severe craniocerebral injury,explore the clinical curative effects of different doses of naloxone,and evaluate the feasibility of the BIS in judging the prognosis of patients with severe craniocerebral injury.Methods: Fifty-five adult patients with severe craniocerebral injury were divided into the control group(18 cases),low-dose naloxone group(group A,18 cases) and high-dose naloxone group(group B,19 cases) according to the admission time.The control group were treated with routine method.The groups A and B were treated with 0.1 mg·kg-1·d-1 and 0.4 mg·kg-1·d-1 naloxone based on the routine method for 14 days.The BIS value in groups A and B were recorded during treatment,and the scores of Glasgow Outcome Scale(GOS) in groups A and B were measured after 1 month of treatment.Results: The differences of the BIS value between three groups were not statistically significant in the first day of admission(P>0.05),and the BIS value in groups A and B after 14 days of admission increased significantly compared with that in the first day of admission(P<0.01).The increasing degree of BIS value after 14 days of admission in group B was significantly higher than that in control group and group A(P<0.01).The scores of GOS in groups A and B were significantly higher than that in control group(P<0.01),and the score of GOS in group B was significantly higher than that in group A after 1 month of admission(P<0.01).The BIS value of patient was significantly positive correlation with the GOS score after 14 days of admission(P<0.01).The differences of the mortality after 1 month of treatment between 3 groups were not statistically significant(P>0.05).Conclusions: The treatment of the severe craniocerebral injury with early large dose naloxone can improve the nerve function,but which can not reduce the mortality of patients.The effect of BIS in evaluating the degree of brain damage and prognosis is good.
Objective: To observe the effects of two different doses of naloxone on Bispectral index(BIS) in patients with severe craniocerebral injury,explore the clinical curative effects of different doses of naloxone,and evaluate the feasibility of the BIS in judging the prognosis of patients with severe craniocerebral injury.Methods: Fifty-five adult patients with severe craniocerebral injury were divided into the control group(18 cases),low-dose naloxone group(group A,18 cases) and high-dose naloxone group(group B,19 cases) according to the admission time.The control group were treated with routine method.The groups A and B were treated with 0.1 mg·kg-1·d-1 and 0.4 mg·kg-1·d-1 naloxone based on the routine method for 14 days.The BIS value in groups A and B were recorded during treatment,and the scores of Glasgow Outcome Scale(GOS) in groups A and B were measured after 1 month of treatment.Results: The differences of the BIS value between three groups were not statistically significant in the first day of admission(P>0.05),and the BIS value in groups A and B after 14 days of admission increased significantly compared with that in the first day of admission(P<0.01).The increasing degree of BIS value after 14 days of admission in group B was significantly higher than that in control group and group A(P<0.01).The scores of GOS in groups A and B were significantly higher than that in control group(P<0.01),and the score of GOS in group B was significantly higher than that in group A after 1 month of admission(P<0.01).The BIS value of patient was significantly positive correlation with the GOS score after 14 days of admission(P<0.01).The differences of the mortality after 1 month of treatment between 3 groups were not statistically significant(P>0.05).Conclusions: The treatment of the severe craniocerebral injury with early large dose naloxone can improve the nerve function,but which can not reduce the mortality of patients.The effect of BIS in evaluating the degree of brain damage and prognosis is good.
2016, 41(8): 1012-1013,1016.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.010
Abstract:
Objective: To investigate the incidence of the stress urinary incontinence(SUI) in postpartum women from Fuyang,and analyze its influencing factors.Methods: A total of 912 postpartum women for 6 to 8 weeks from the First People's Hospital of Fuyang were selected.The incidence of SUI in postpartum women were investigated,and the influence factors on SUI were analyzed.Results: The incidence of postpartum SUI was 39.5%,the morbidity of SUI increased with the increasing of the age of postpartum women(P<0.01),The large BMI in pregnant woman with 20 weeks of gestation could easy lead to the SUI(P<0.05).The morbidity of SUI in cesarean section puerpera was significantly lower than that in vaginal delivery and forceps delivery puerperas(P<0.01).Multivariate analysis showed that the elderly age was the risk factor of SUI,and compared with the vaginal delivery and forceps delivery,the cesarean section can reduce the risks of SUI(P<0.01).Conclusions: Age and delivery mode can affect the occurrence of SUI in postpartum women.
Objective: To investigate the incidence of the stress urinary incontinence(SUI) in postpartum women from Fuyang,and analyze its influencing factors.Methods: A total of 912 postpartum women for 6 to 8 weeks from the First People's Hospital of Fuyang were selected.The incidence of SUI in postpartum women were investigated,and the influence factors on SUI were analyzed.Results: The incidence of postpartum SUI was 39.5%,the morbidity of SUI increased with the increasing of the age of postpartum women(P<0.01),The large BMI in pregnant woman with 20 weeks of gestation could easy lead to the SUI(P<0.05).The morbidity of SUI in cesarean section puerpera was significantly lower than that in vaginal delivery and forceps delivery puerperas(P<0.01).Multivariate analysis showed that the elderly age was the risk factor of SUI,and compared with the vaginal delivery and forceps delivery,the cesarean section can reduce the risks of SUI(P<0.01).Conclusions: Age and delivery mode can affect the occurrence of SUI in postpartum women.
2016, 41(8): 1014-1016.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.011
Abstract:
Objective: To investigate the effects of the light sedation induced by low dose midazolam on cough induced by fentanyl.Methods: Sixty patients scheduled by general anesthesia operation were divided into the control group and midazolam group using a random number table(30 cases each group).The midazolam group were intravenously injected with 0.03 mg/kg(1 mg/mL) of midazolam.The control group were intravenously injected with equal amount of 0.9% sodium chloride injection for 3 s,and the 3 μg/kg(50 μg/mL) of fentanyl was used for 3 s after 120 s.The occurrence rate and degree of cough,the anesthesia/awareness depth and modified OAA/S score at the time of using fentanyl were recorded after 120 s of treatment.Results: Compared with the control group,the incidence and severity of cough significantly increased in midazolam group(P<0.01),the value of the depth of anesthesia/consciousness significantly decreased in midazolam group,which arrived at light sedation(P<0.01).The score of modified OAA/S in midazolam group was more than or equal to 4 points after the intravenous injection of fentanyl.Conclusions: At the time of light sedation induced by a low dose of midazolam,the incidence and severity of cough caused by intravenous injection fentanyl increase.
Objective: To investigate the effects of the light sedation induced by low dose midazolam on cough induced by fentanyl.Methods: Sixty patients scheduled by general anesthesia operation were divided into the control group and midazolam group using a random number table(30 cases each group).The midazolam group were intravenously injected with 0.03 mg/kg(1 mg/mL) of midazolam.The control group were intravenously injected with equal amount of 0.9% sodium chloride injection for 3 s,and the 3 μg/kg(50 μg/mL) of fentanyl was used for 3 s after 120 s.The occurrence rate and degree of cough,the anesthesia/awareness depth and modified OAA/S score at the time of using fentanyl were recorded after 120 s of treatment.Results: Compared with the control group,the incidence and severity of cough significantly increased in midazolam group(P<0.01),the value of the depth of anesthesia/consciousness significantly decreased in midazolam group,which arrived at light sedation(P<0.01).The score of modified OAA/S in midazolam group was more than or equal to 4 points after the intravenous injection of fentanyl.Conclusions: At the time of light sedation induced by a low dose of midazolam,the incidence and severity of cough caused by intravenous injection fentanyl increase.
2016, 41(8): 1017-1020.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.012
Abstract:
Objective: To compare the clinical effects of remnant preservation and remnant remove in anterior cruciate ligament(ACL) reconstruction under arthroscopy.Methods: The clinical data of 70 ACL rupture patients followed by 12 months were retrospectively analyzed.The observation group(35 cases) and control group(35 cases) were treated with ACL reconstruction through remnant preservation and remove,respectively.The joint stability,joint function and proprioception recovery between two groups were analyzed.Results: All patients were followed up for 12 to 27 months.The difference of joint stability between two groups was not statistically significant(P>0.05).At the end of following up,the joint function in observation group was better than that in control group(P<0.01).The proprioception in observation group was better than that in control group(P<0.01).Conclusions: The effects of remnant preservation and remove in the anterior cruciate ligament reconstruction under arthroscopy are good,and which can recover the joint stability.The remnant preservation method can more conducive to the recovery of knee joint function and proprioception.
Objective: To compare the clinical effects of remnant preservation and remnant remove in anterior cruciate ligament(ACL) reconstruction under arthroscopy.Methods: The clinical data of 70 ACL rupture patients followed by 12 months were retrospectively analyzed.The observation group(35 cases) and control group(35 cases) were treated with ACL reconstruction through remnant preservation and remove,respectively.The joint stability,joint function and proprioception recovery between two groups were analyzed.Results: All patients were followed up for 12 to 27 months.The difference of joint stability between two groups was not statistically significant(P>0.05).At the end of following up,the joint function in observation group was better than that in control group(P<0.01).The proprioception in observation group was better than that in control group(P<0.01).Conclusions: The effects of remnant preservation and remove in the anterior cruciate ligament reconstruction under arthroscopy are good,and which can recover the joint stability.The remnant preservation method can more conducive to the recovery of knee joint function and proprioception.
2016, 41(8): 1020-1022.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.013
Abstract:
Objective: To investigate the clinical effects of medical adhesives combined with mini-titanium plate in the application of maxillary comminuted fracture.Methods: Forty-three patients with maxillary comminuted fracture were treated with oral vestibular combined with palpebral margin incision,reseting the lower edge of orbital bone,frontal process of maxilla and zygomatic process,and internal fixation with mini-titanium plate.The comminuted fracture of the maxillary sinus wall were treated with medical adhesives,the effect of which was observed.Results: All patients recovered well,26 cases were markedly effective,13 cases were effective,4 cases were ineffective,the cure rate were 93%.The postoperative CT showed that the face was bilateral symmetry,the fracture shape recovery well and the deformed improved significantly.The patients were followed up for 3 to 6 months,no obvious facial deformation was found,and occlusal relationship was normal.Conclusions: The restoration effects of the medical adhesives combined with mini-titanium plate in the restoration of maxillary comminuted fracture is stable and reliable.The operation process is simple,safe,economical and practical,which is suitable for clinical use.
Objective: To investigate the clinical effects of medical adhesives combined with mini-titanium plate in the application of maxillary comminuted fracture.Methods: Forty-three patients with maxillary comminuted fracture were treated with oral vestibular combined with palpebral margin incision,reseting the lower edge of orbital bone,frontal process of maxilla and zygomatic process,and internal fixation with mini-titanium plate.The comminuted fracture of the maxillary sinus wall were treated with medical adhesives,the effect of which was observed.Results: All patients recovered well,26 cases were markedly effective,13 cases were effective,4 cases were ineffective,the cure rate were 93%.The postoperative CT showed that the face was bilateral symmetry,the fracture shape recovery well and the deformed improved significantly.The patients were followed up for 3 to 6 months,no obvious facial deformation was found,and occlusal relationship was normal.Conclusions: The restoration effects of the medical adhesives combined with mini-titanium plate in the restoration of maxillary comminuted fracture is stable and reliable.The operation process is simple,safe,economical and practical,which is suitable for clinical use.
2016, 41(8): 1023-1025.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.014
Abstract:
Objective: To analyze the expressions of P27 in different clinical and pathological type of glandularis cystitis,and provide the basis in judging the malignant change of different types of glandularis cystitis.Methods: Eighty-five patients with glandularis cystitis were divided into the different clinical and pathological type,25 normal bladder mucosa tissues were set as the control.The P27 expressions in glandularis cystitis tissue and normal bladder mucosa tissue were detected by immunohistocemistry S-P method,the result of which was analyzed using the automatic microscope and image analysis system.Results: Among the different clinical types of glandularis cystitis tissue,the positive expressions of P27 in nipple and intestinal adenoma type cystitis were significantly lower than that in normal bladder mucosa tissue(P<0.01).However,the differences of the positive expressions of P27 between chronic inflammatory type,follicular type and normal bladder mucosa tissue were not statistically significant(P>0.05).Among the different pathological types of glandularis cystitis tissue,the positive expressions of P27 in intestinal epithelial and prostatic intraepithelial neoplasia type cystitis were significantly lower than that in normal bladder mucosa tissue(P<0.01).However,the difference of the positive expression of P27 between transitional type and normal bladder mucosa tissue was not statistically significant(P>0.05).Conclusions: In the clinical type,the nipple and intestinal type glandularis cystitis may be precancerous lesion.In the pathological type,the intestinal epithelial and prostate epithelial type of glandularis cystitis may be precancerous lesion.The cancer possibility in patient with nipple and intestinal adenoma type of gladnularis cystitis complicated with intestinal metaplasia of prostate epithelial metaplasia is large,and the patient should be treated with positive operation,bladder instillation and close following-up.
Objective: To analyze the expressions of P27 in different clinical and pathological type of glandularis cystitis,and provide the basis in judging the malignant change of different types of glandularis cystitis.Methods: Eighty-five patients with glandularis cystitis were divided into the different clinical and pathological type,25 normal bladder mucosa tissues were set as the control.The P27 expressions in glandularis cystitis tissue and normal bladder mucosa tissue were detected by immunohistocemistry S-P method,the result of which was analyzed using the automatic microscope and image analysis system.Results: Among the different clinical types of glandularis cystitis tissue,the positive expressions of P27 in nipple and intestinal adenoma type cystitis were significantly lower than that in normal bladder mucosa tissue(P<0.01).However,the differences of the positive expressions of P27 between chronic inflammatory type,follicular type and normal bladder mucosa tissue were not statistically significant(P>0.05).Among the different pathological types of glandularis cystitis tissue,the positive expressions of P27 in intestinal epithelial and prostatic intraepithelial neoplasia type cystitis were significantly lower than that in normal bladder mucosa tissue(P<0.01).However,the difference of the positive expression of P27 between transitional type and normal bladder mucosa tissue was not statistically significant(P>0.05).Conclusions: In the clinical type,the nipple and intestinal type glandularis cystitis may be precancerous lesion.In the pathological type,the intestinal epithelial and prostate epithelial type of glandularis cystitis may be precancerous lesion.The cancer possibility in patient with nipple and intestinal adenoma type of gladnularis cystitis complicated with intestinal metaplasia of prostate epithelial metaplasia is large,and the patient should be treated with positive operation,bladder instillation and close following-up.
2016, 41(8): 1026-1028.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.015
Abstract:
Objective: To evaluate the clinical effects of the intraperitoneal and retroperitoneal approach under laparoscope on renal cyst unroofing and decompression.Methods: Ninety patients with renal cyst were divided into the group A,B and C according to the surgical method(30 cases each group).Group A,B and C were treated with renal cyst unroofing and decompression through the retroperitoneal,intraperitoneal and open approach,respectively.The operation effects among 3 groups were compared.Results: The operation time,peroperative bleeding,gastrointestinal function recovery time and hospital stay time in group A and B were significantly less than those in group C(P<0.01).The operative time,peroperative bleeding and gastrointestinal function recovery time in group A were significantly less than those in group B(P<0.01).No complication was found in group A,and the incidence rates of complication in group B and group C were 3.33% and 26.67%,respectively.The differences of the incidence rates of intestinal obstruction among 3 groups were statistically significant(P<0.05).The differences of the incidence rates of infection and urinary retention among 3 groups were not statistically significant(P>0.05).Conclusions: Compared with the open renal cyst surgery,the laparoscopic surgery is less trauma,good effect and quick recovery.Compared with the intraperitoneal approach,the renal cyst unroofing and decompression through retroperitoneal approach is shorter operation time and fewer complications.
Objective: To evaluate the clinical effects of the intraperitoneal and retroperitoneal approach under laparoscope on renal cyst unroofing and decompression.Methods: Ninety patients with renal cyst were divided into the group A,B and C according to the surgical method(30 cases each group).Group A,B and C were treated with renal cyst unroofing and decompression through the retroperitoneal,intraperitoneal and open approach,respectively.The operation effects among 3 groups were compared.Results: The operation time,peroperative bleeding,gastrointestinal function recovery time and hospital stay time in group A and B were significantly less than those in group C(P<0.01).The operative time,peroperative bleeding and gastrointestinal function recovery time in group A were significantly less than those in group B(P<0.01).No complication was found in group A,and the incidence rates of complication in group B and group C were 3.33% and 26.67%,respectively.The differences of the incidence rates of intestinal obstruction among 3 groups were statistically significant(P<0.05).The differences of the incidence rates of infection and urinary retention among 3 groups were not statistically significant(P>0.05).Conclusions: Compared with the open renal cyst surgery,the laparoscopic surgery is less trauma,good effect and quick recovery.Compared with the intraperitoneal approach,the renal cyst unroofing and decompression through retroperitoneal approach is shorter operation time and fewer complications.
2016, 41(8): 1029-1032.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.016
Abstract:
Objective: To explore the analgesia effects of dexmedetomidine combined with ropivacaine block after total abdominal hysterectomy.Methods: Seventy patients scheduled by total hysterectomy were radomly divided into the control group and observation group(36 cases each group).The control group were blocked by ropivacaine transabdominal fascia plane guided by ultrasound,the observation group were blocked by dexmedetomidine combined with ropivacaine transabdominal fascia plane guided by ultrasound.Results: The pain scores in observation group at postoperative 4 h,12 h and 24 h were significantly lower than those in control group(P<0.01).The differences of the scores at postoperative 4 h,12 h and 24 h between two groups were statistically significant(P<0.01).The complications(including dizziness,nausea,vomiting,drowsiness,respiratory depression,urinary retention) in observation group at postoperative 24 h were significantly less than those in control group(P<0.05).The overall analgesic satisfaction scores in observation group and control group were was statistically significant(P<0.01).Conclusions: The dexmedetomidine combined with ropivacaine transabdominal fascia plane guided by ultrasound after total hysterectomy can effectively play the analgesia and sedation effects,reduce the complications and improve satisfaction of patients.
Objective: To explore the analgesia effects of dexmedetomidine combined with ropivacaine block after total abdominal hysterectomy.Methods: Seventy patients scheduled by total hysterectomy were radomly divided into the control group and observation group(36 cases each group).The control group were blocked by ropivacaine transabdominal fascia plane guided by ultrasound,the observation group were blocked by dexmedetomidine combined with ropivacaine transabdominal fascia plane guided by ultrasound.Results: The pain scores in observation group at postoperative 4 h,12 h and 24 h were significantly lower than those in control group(P<0.01).The differences of the scores at postoperative 4 h,12 h and 24 h between two groups were statistically significant(P<0.01).The complications(including dizziness,nausea,vomiting,drowsiness,respiratory depression,urinary retention) in observation group at postoperative 24 h were significantly less than those in control group(P<0.05).The overall analgesic satisfaction scores in observation group and control group were was statistically significant(P<0.01).Conclusions: The dexmedetomidine combined with ropivacaine transabdominal fascia plane guided by ultrasound after total hysterectomy can effectively play the analgesia and sedation effects,reduce the complications and improve satisfaction of patients.
2016, 41(8): 1032-1034.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.017
Abstract:
Objective: To compare the clinical effects of Lichtenstein and Rutkow procedures in the treatment of inguinal hernia.Methods: The data of 111 patients treated with one-side open tension-free herniorrhaphy combined with following up were retrospectively analyzed from June.2013 to Dec.2014.The patients were divided into the Lichtenstein and Rutkow operation group according to the operation pattern.The clinical effects between two groups were compared.Results: The differences of preoperative general status,complication,hernia type,operation time,postoperative activity and recovery time,scrotal edema,surgical site infection and recurrence between two groups were not statistically significant(P>0.05).The VAS score of postoperative 3 months and foreign-body sensation in Lichtenstein operation group were lower than those in Rutkow operation group(P<0.05 and P<0.01).Conclusions: The Lichtenstein operation is less cost,light foreign-body sensation and less chronic pain.There were no differences in the recurrence,complication and postoperative recovery between two groups.Lichtenstein procedure can be regarded as the principal choice in the treatment of hernia in primary hospital.
Objective: To compare the clinical effects of Lichtenstein and Rutkow procedures in the treatment of inguinal hernia.Methods: The data of 111 patients treated with one-side open tension-free herniorrhaphy combined with following up were retrospectively analyzed from June.2013 to Dec.2014.The patients were divided into the Lichtenstein and Rutkow operation group according to the operation pattern.The clinical effects between two groups were compared.Results: The differences of preoperative general status,complication,hernia type,operation time,postoperative activity and recovery time,scrotal edema,surgical site infection and recurrence between two groups were not statistically significant(P>0.05).The VAS score of postoperative 3 months and foreign-body sensation in Lichtenstein operation group were lower than those in Rutkow operation group(P<0.05 and P<0.01).Conclusions: The Lichtenstein operation is less cost,light foreign-body sensation and less chronic pain.There were no differences in the recurrence,complication and postoperative recovery between two groups.Lichtenstein procedure can be regarded as the principal choice in the treatment of hernia in primary hospital.
2016, 41(8): 1035-1037,1041.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.018
Abstract:
Objective: To analyze the risk factors of hemorrhagic transformation in cardioembolism patients.Methods: The patients with cardioembolism within 1 week were divided into the hemorrhagic transformation group and non-hemorrhagic transformation group according to whether the patients suffered from hemorrhagic transformation or not.The age,gender,area of infarction,serum lipoprotein,pulse pressure difference on admission,random blood glucose,creatinine and treatment program(anticoagulant or antiplatelet aggregation) in two groups were analyzed.The significant variant analyzed by single factor analysis was analyzed using multivariate logistic regression analysis.Results: Among 100 patients,the hemorrhagic transformation in 34 cases(34%) were identified,and the differences of the age,fast blood glucose,area of infarction and treatment program between two groups were statistically significant(P<0.01).The area of infarction increased with the increasing of age,and the higher the random blood glucose was,the higher the likelihood of bleeding was(P<0.05 to P<0.01).Conclusions: The age,infarction size and fast blood glucose are the independent risk factor of hemorrhagic transformation in cardioembolism.
Objective: To analyze the risk factors of hemorrhagic transformation in cardioembolism patients.Methods: The patients with cardioembolism within 1 week were divided into the hemorrhagic transformation group and non-hemorrhagic transformation group according to whether the patients suffered from hemorrhagic transformation or not.The age,gender,area of infarction,serum lipoprotein,pulse pressure difference on admission,random blood glucose,creatinine and treatment program(anticoagulant or antiplatelet aggregation) in two groups were analyzed.The significant variant analyzed by single factor analysis was analyzed using multivariate logistic regression analysis.Results: Among 100 patients,the hemorrhagic transformation in 34 cases(34%) were identified,and the differences of the age,fast blood glucose,area of infarction and treatment program between two groups were statistically significant(P<0.01).The area of infarction increased with the increasing of age,and the higher the random blood glucose was,the higher the likelihood of bleeding was(P<0.05 to P<0.01).Conclusions: The age,infarction size and fast blood glucose are the independent risk factor of hemorrhagic transformation in cardioembolism.
2016, 41(8): 1038-1041.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.019
Abstract:
Objective: To investigate the effects of dexmedetomidine on the levels of S100β protein and neuron specific enolase(NSE) in removal of intracranial hematoma patients.Methods: Forty patients scheduled by removal of intracranial hematoma were randomly divided into the dexmedetomidine group(group D) and control group(group C)(20 cases each group).In group D,the 10 mL/h(4 μg/mL) of dexmedetomidine was continuously infused by pump before 10 min of anesthesia,and stopped until the end of operation,and then the 2 mL/h(6 μg/mL) of dexmedetomidine was infused by vein for 48 h after the surgery.In group C the same volume of saline was infused.The anesthesia method,induction and maintenance in two groups were the same.The levels of S100β protein and neuron specific enolase before the dexmedetomidine infusing(T0),the end of operation(T1),and after 6 h(T2),12 h(T3),24 h(T4),36 h(T5) and 48 h(T6) of operation in two groups were detected by ELISA.Results: Compared with the T0,the levels of plasma S100β protein and NSE in group D decreased significantly from T1 to T6(P<0.01),the differences of the plasma S100β protein in group C from T1 to T6 were not statistically significant(P>0.05),but the levels of NSE in group C from T2 to T6 increased significantly(P<0.01).The levels of S100β protein and NSE in group D from T1 to T6 were significantly lower than those in group C(P<0.01).Conclusions: The dexmedetomidine can effectively reduce the levels of the S100β protein,and alleviate the brain injury in removal of intracranial hematoma patients
Objective: To investigate the effects of dexmedetomidine on the levels of S100β protein and neuron specific enolase(NSE) in removal of intracranial hematoma patients.Methods: Forty patients scheduled by removal of intracranial hematoma were randomly divided into the dexmedetomidine group(group D) and control group(group C)(20 cases each group).In group D,the 10 mL/h(4 μg/mL) of dexmedetomidine was continuously infused by pump before 10 min of anesthesia,and stopped until the end of operation,and then the 2 mL/h(6 μg/mL) of dexmedetomidine was infused by vein for 48 h after the surgery.In group C the same volume of saline was infused.The anesthesia method,induction and maintenance in two groups were the same.The levels of S100β protein and neuron specific enolase before the dexmedetomidine infusing(T0),the end of operation(T1),and after 6 h(T2),12 h(T3),24 h(T4),36 h(T5) and 48 h(T6) of operation in two groups were detected by ELISA.Results: Compared with the T0,the levels of plasma S100β protein and NSE in group D decreased significantly from T1 to T6(P<0.01),the differences of the plasma S100β protein in group C from T1 to T6 were not statistically significant(P>0.05),but the levels of NSE in group C from T2 to T6 increased significantly(P<0.01).The levels of S100β protein and NSE in group D from T1 to T6 were significantly lower than those in group C(P<0.01).Conclusions: The dexmedetomidine can effectively reduce the levels of the S100β protein,and alleviate the brain injury in removal of intracranial hematoma patients
2016, 41(8): 1042-1044.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.020
Abstract:
Objective: To observe the effects of the surgery timing on the minimally invasive puncture in the treatment of hypertensive intracerebral hemorrhage.Methods: Two hundred and forty-one patients with hypertensive intracerebral hemorrhage were divided into the ultra-early group(80 cases),early group(81 cases) and late group(80 cases) according to the operation time after the onset of hemorrhage.All patients were treated with the minimally invasive surgery,and the clinical effects between three groups were compared with the excellent rates of Glasgow Outcome Scale at postoperative 2 weeks,and Barthel Index Scale at postoperative 3 months.The long-term functional recovery,postoperative complications and re-bleeding between three groups were compared.Results: The excellent rates of Glasgow Outcome Scale at postoperative 2 weeks,and Barthel Index Scale at postoperative 3 months in ultra-early group were higher than those in other two groups(P<0.05 to P<0.01).The differences of the incidence of re-bleeding between three groups were statistically significant(P<0.05),but the differences of the incidence of complications between three groups were not statistically significant(P>0.05).Conclusions: The minimally invasive surgery at ultra-early stage can be beneficial to the short-term and long-term functional recovery of patients with hypertensive intracerebral hemorrhage,which is an ideal surgery timing.
Objective: To observe the effects of the surgery timing on the minimally invasive puncture in the treatment of hypertensive intracerebral hemorrhage.Methods: Two hundred and forty-one patients with hypertensive intracerebral hemorrhage were divided into the ultra-early group(80 cases),early group(81 cases) and late group(80 cases) according to the operation time after the onset of hemorrhage.All patients were treated with the minimally invasive surgery,and the clinical effects between three groups were compared with the excellent rates of Glasgow Outcome Scale at postoperative 2 weeks,and Barthel Index Scale at postoperative 3 months.The long-term functional recovery,postoperative complications and re-bleeding between three groups were compared.Results: The excellent rates of Glasgow Outcome Scale at postoperative 2 weeks,and Barthel Index Scale at postoperative 3 months in ultra-early group were higher than those in other two groups(P<0.05 to P<0.01).The differences of the incidence of re-bleeding between three groups were statistically significant(P<0.05),but the differences of the incidence of complications between three groups were not statistically significant(P>0.05).Conclusions: The minimally invasive surgery at ultra-early stage can be beneficial to the short-term and long-term functional recovery of patients with hypertensive intracerebral hemorrhage,which is an ideal surgery timing.
2016, 41(8): 1045-1047.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.021
Abstract:
Objective: To compare the clinical characteristics of hyperlipidemic acute pancreatitis(HLAP) and acute biliary pancreatitis(ABP),and improve the diagnosis and treatment of HLAP.Methods: Eighty-eight patients with pancreatitis were divided into the HLAP group(28 cases) and ABP group(60 cases) according to the pathogeny.The general clinical data,main biochemical index,imaging data,accompanying disease,mortality and recurrence rate between two groups were compared.Results: The hyperlipidemia pancreatitis complicated with fatty liver,diabetes mellitus,severe pancreatitis and recurrence rate in HLAP group were more than those in ABP group(P<0.05-P<0.01),but the APACHEⅡ and the incidence of severe acute pancreatitis were higher than in ABP group.Conclusions: The HLAP patient has unique clinical characteristics,and its clinical manifestation is not typical,which complicated with foundation disease is more and easy to recur.In addition to the conventional treatment,quick reducing the blood lipid level is the key of treatment as soon as possible.
Objective: To compare the clinical characteristics of hyperlipidemic acute pancreatitis(HLAP) and acute biliary pancreatitis(ABP),and improve the diagnosis and treatment of HLAP.Methods: Eighty-eight patients with pancreatitis were divided into the HLAP group(28 cases) and ABP group(60 cases) according to the pathogeny.The general clinical data,main biochemical index,imaging data,accompanying disease,mortality and recurrence rate between two groups were compared.Results: The hyperlipidemia pancreatitis complicated with fatty liver,diabetes mellitus,severe pancreatitis and recurrence rate in HLAP group were more than those in ABP group(P<0.05-P<0.01),but the APACHEⅡ and the incidence of severe acute pancreatitis were higher than in ABP group.Conclusions: The HLAP patient has unique clinical characteristics,and its clinical manifestation is not typical,which complicated with foundation disease is more and easy to recur.In addition to the conventional treatment,quick reducing the blood lipid level is the key of treatment as soon as possible.
2016, 41(8): 1048-1049.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.022
Abstract:
Objective: To explore the clinical value and safety of the pleural biopsy in the diagnosis of exudative pleural effusion.Methods: One hundred and eighty-three patients with pleural effusion of unknown reasons were treated with pleural biopsy,and the acid-fast bacillus and exfoliated cells in pleural effusion were detected.Results: The success rate of the taking sample though pleural biopsy was 90%.The pathological examination results showed that the obvious etiology in 112 patients were identified,the positive rate of which was 65.5%.Among 112 patients,the 40.9% of patients with tuberculous pleurisy was diagnosed,and the positive rate of tumor was 24.6%.During the 190 times of puncture,the pleural reactions in 8 cases(4.2%),and pneumothorax in 17 cases and no severe complications(such as chest infection or severe bleeding) were found.Conclusions: Pleural biopsy is simple,safe and effective,especially suitable for county hospitals.
Objective: To explore the clinical value and safety of the pleural biopsy in the diagnosis of exudative pleural effusion.Methods: One hundred and eighty-three patients with pleural effusion of unknown reasons were treated with pleural biopsy,and the acid-fast bacillus and exfoliated cells in pleural effusion were detected.Results: The success rate of the taking sample though pleural biopsy was 90%.The pathological examination results showed that the obvious etiology in 112 patients were identified,the positive rate of which was 65.5%.Among 112 patients,the 40.9% of patients with tuberculous pleurisy was diagnosed,and the positive rate of tumor was 24.6%.During the 190 times of puncture,the pleural reactions in 8 cases(4.2%),and pneumothorax in 17 cases and no severe complications(such as chest infection or severe bleeding) were found.Conclusions: Pleural biopsy is simple,safe and effective,especially suitable for county hospitals.
2016, 41(8): 1050-1052.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.023
Abstract:
Objective: To explore expression of the SUZ12 of PRC2 subunit in colorectal cancer tissue,and its correlation with clinical pathological features.Methods: Eighty-five patients treated with laparoscopic colorectal cancer resection were investigated,the colorectal cancer specimen during surgical resection was collected,and all patients were not treated with chemoradiation therapy before operation.The normal tissue distance from carcinoma tissue edge for 15 cm was set as the control group.The protein content of SUZ12 in colorectal cancer tissue and normal tissue were determined.The expression level of SUZ12 in colorectal cancer tissue was evaluated according to the proportions of positive staining intensity and positive cell nucleus.Results: The positive marking scores of comb SUZ12 protein in left half colon cancer group,transverse colon cancer group,right half colon,sigmoid colon cancer,rectal cancer group and control group increased(P<0.05 to P<0.01).The positive marker scores of SUZ12 in TNM stage Ⅲ to Ⅳ colorectal cancer were higher than that in TNM stage Ⅰ to Ⅱ colorectal cancer(P<0.01),the positive marker scores of SUZ12 in moderate and high differentiation carcinoma tissue were higher than those in undifferentiated and low differentiation carcinoma tissue(P<0.01),and the positive marker score of SUZ12 in colorectal cancer with lymph node metastasis was higher than that in colorectal cancer without lymph node metastasis(P<0.01).The differences of the positive marker scores of SUZ12 in age and sex of patients,tumor diameter,tumor site and tumor infiltration depth were not statistically significant(P>0.05).Conclusions: SUZ12 protein can be used as the evaluation index of tumor malignant degree,which is crucial in the early diagnosis of colorectal cancer,improving treatment and prolonging the survival time of patients.
Objective: To explore expression of the SUZ12 of PRC2 subunit in colorectal cancer tissue,and its correlation with clinical pathological features.Methods: Eighty-five patients treated with laparoscopic colorectal cancer resection were investigated,the colorectal cancer specimen during surgical resection was collected,and all patients were not treated with chemoradiation therapy before operation.The normal tissue distance from carcinoma tissue edge for 15 cm was set as the control group.The protein content of SUZ12 in colorectal cancer tissue and normal tissue were determined.The expression level of SUZ12 in colorectal cancer tissue was evaluated according to the proportions of positive staining intensity and positive cell nucleus.Results: The positive marking scores of comb SUZ12 protein in left half colon cancer group,transverse colon cancer group,right half colon,sigmoid colon cancer,rectal cancer group and control group increased(P<0.05 to P<0.01).The positive marker scores of SUZ12 in TNM stage Ⅲ to Ⅳ colorectal cancer were higher than that in TNM stage Ⅰ to Ⅱ colorectal cancer(P<0.01),the positive marker scores of SUZ12 in moderate and high differentiation carcinoma tissue were higher than those in undifferentiated and low differentiation carcinoma tissue(P<0.01),and the positive marker score of SUZ12 in colorectal cancer with lymph node metastasis was higher than that in colorectal cancer without lymph node metastasis(P<0.01).The differences of the positive marker scores of SUZ12 in age and sex of patients,tumor diameter,tumor site and tumor infiltration depth were not statistically significant(P>0.05).Conclusions: SUZ12 protein can be used as the evaluation index of tumor malignant degree,which is crucial in the early diagnosis of colorectal cancer,improving treatment and prolonging the survival time of patients.
2016, 41(8): 1053-1055.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.024
Abstract:
Objective: To study the correlations of coronary artery disease(CHD)injury degree in CHD patients and carotid intima-middle thickness(IMT),plasma B-type natriuretic peptide(BNP) and uric acid(UA) levels.Methods: One hundred and six CHD cases who confirmed by coronary angiography were selected as CHD group,80 cases with negative results by coronary angiography were as control group.All patients in the two groups were ruled out severe liver,kidney,lung,brain and other heart disease.According to the degree of coronary artery lesions,the patients in CHD group were divided into single lesion group of 45 cases,2 lesions group of 31 cases and 3 lesions group of 30 cases.The correlations of the pathological change degree of coronary artery,carotid atherosclerosis and the levels of plasma BNP and UA were analyzed.The correlations of coronary artery lesions injury degree and carotid IMT,plasma BNP,UA levels among the different groups were analyzed statistically.Results: IMT,the levels of plasma BNP and UA in CHD group were obviously higher than those in control group(P<0.01),with the number increase of coronary artery lesion,there showed an increasing trend of IMT,plasma BNP and UA levels(P<0.01).Carotid IMT in 3 lesions group was significantly higher than that in single lesion and 2 lesions groups(P<0.01),carotid IMT in 2 lesions group was obviously higher than that in single lesion group(P<0.01).Conclusions: Carotid IMT,plasma BNP,UA levels were correlated with coronary artery disease degree,the combined determination of carotid IMT and plasma BNP,UA levels can predict the injury extent of coronary artery lesions.
Objective: To study the correlations of coronary artery disease(CHD)injury degree in CHD patients and carotid intima-middle thickness(IMT),plasma B-type natriuretic peptide(BNP) and uric acid(UA) levels.Methods: One hundred and six CHD cases who confirmed by coronary angiography were selected as CHD group,80 cases with negative results by coronary angiography were as control group.All patients in the two groups were ruled out severe liver,kidney,lung,brain and other heart disease.According to the degree of coronary artery lesions,the patients in CHD group were divided into single lesion group of 45 cases,2 lesions group of 31 cases and 3 lesions group of 30 cases.The correlations of the pathological change degree of coronary artery,carotid atherosclerosis and the levels of plasma BNP and UA were analyzed.The correlations of coronary artery lesions injury degree and carotid IMT,plasma BNP,UA levels among the different groups were analyzed statistically.Results: IMT,the levels of plasma BNP and UA in CHD group were obviously higher than those in control group(P<0.01),with the number increase of coronary artery lesion,there showed an increasing trend of IMT,plasma BNP and UA levels(P<0.01).Carotid IMT in 3 lesions group was significantly higher than that in single lesion and 2 lesions groups(P<0.01),carotid IMT in 2 lesions group was obviously higher than that in single lesion group(P<0.01).Conclusions: Carotid IMT,plasma BNP,UA levels were correlated with coronary artery disease degree,the combined determination of carotid IMT and plasma BNP,UA levels can predict the injury extent of coronary artery lesions.
2016, 41(8): 1056-1057,1060.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.025
Abstract:
Objective: To investigate the expression levels of vascular endothelial growth factor(VEGF) and kinase domain receptor(KDR) in breast cancer tissue,and its correlation with local angiogenesis.Methods: The expression levels of VEGF and KDR in 40 cases of breast cancer tissue and normal breast tissue were detected by immunohistochemical method.The labeled CD34 was used to detect the microvessel density(MVD).Results: The positive expression rates of VEGF and KDR,and MVD in breast cancer tissue were significantly higher than those in normal breast tissue(P<0.01).In breast cancer tissue,the expression level of VEGF was positively correlated to the expression level of KDR(P<0.01),and the VEGF and KDR were positively correlated with the MVD(P<0.01).The MVD in VEGF and KDR positive tissue was significantly higher than that in VEGF and KDR negative tissue(P<0.01).Conclusions: The expression rates of VEGF and KDR in breast cancer tissue increase,which is involved in the formation of tumor vessel.
Objective: To investigate the expression levels of vascular endothelial growth factor(VEGF) and kinase domain receptor(KDR) in breast cancer tissue,and its correlation with local angiogenesis.Methods: The expression levels of VEGF and KDR in 40 cases of breast cancer tissue and normal breast tissue were detected by immunohistochemical method.The labeled CD34 was used to detect the microvessel density(MVD).Results: The positive expression rates of VEGF and KDR,and MVD in breast cancer tissue were significantly higher than those in normal breast tissue(P<0.01).In breast cancer tissue,the expression level of VEGF was positively correlated to the expression level of KDR(P<0.01),and the VEGF and KDR were positively correlated with the MVD(P<0.01).The MVD in VEGF and KDR positive tissue was significantly higher than that in VEGF and KDR negative tissue(P<0.01).Conclusions: The expression rates of VEGF and KDR in breast cancer tissue increase,which is involved in the formation of tumor vessel.
2016, 41(8): 1058-1060.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.026
Abstract:
Objective: To evaluate the clinical curative efficacy of adriamycin peripheral nerve block in the treatment of trigeminal neuralgia.Methods: Eighty patients with trigeminal neuralgia were divided into the anhydrous ethanol group and adriamycin group using random number table method(40 cases each group).The clinical efficacy,visual analog scale(VAS) score and adverse reaction between two groups were compared.Results: The clinical curative efficacy in adriamycin group was higher than that in anhydrous ethanol group(P<0.05).Compared before operation,the VAS scores in two groups decreased significantly after 1 week,1 month,6 months and 1 year of operation(P<0.01),and the decreasing degree of which in adriamycin group was significantly higher that in anhydrous ethanol group(P<0.01).The differences of the nausea and vomiting,dizziness,headache,regional numbness and recurrence rate between two groups were not statistically significant(P>0.05).Conclusions: The clinical curative efficacy of adriamycin peripheral nerve block in the treatment of trigeminal neuralgia is distinct,which can relieve pain,does not increase the incidence of adverse reaction,and is worthy of popularization and application.
Objective: To evaluate the clinical curative efficacy of adriamycin peripheral nerve block in the treatment of trigeminal neuralgia.Methods: Eighty patients with trigeminal neuralgia were divided into the anhydrous ethanol group and adriamycin group using random number table method(40 cases each group).The clinical efficacy,visual analog scale(VAS) score and adverse reaction between two groups were compared.Results: The clinical curative efficacy in adriamycin group was higher than that in anhydrous ethanol group(P<0.05).Compared before operation,the VAS scores in two groups decreased significantly after 1 week,1 month,6 months and 1 year of operation(P<0.01),and the decreasing degree of which in adriamycin group was significantly higher that in anhydrous ethanol group(P<0.01).The differences of the nausea and vomiting,dizziness,headache,regional numbness and recurrence rate between two groups were not statistically significant(P>0.05).Conclusions: The clinical curative efficacy of adriamycin peripheral nerve block in the treatment of trigeminal neuralgia is distinct,which can relieve pain,does not increase the incidence of adverse reaction,and is worthy of popularization and application.
2016, 41(8): 1061-1063,1067.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.027
Abstract:
Objective: To explore the clinical efficacy of human albumin in the treatment of progressive cerebral infarction,and its affecting factors.Methods: Among 130 patients with progressive cerebral infarction,67 cases were treated with human serum albumin combined with symptomatic treatment(observation group),and 63 cases were treated with symptomatic treatment(control group).The blood viscosity,National Institutes of Health Stroke Scale(NIHSS) score,efficacy and adverse reaction between two groups were compared after 10 days of treatment.The affecting factors of curative efficacy were analyzed using the logistics regression.Results: Compared before treatment,the high,middle and low shear viscosity in two groups were significantly decreased after treatment(P<0.01),and the decreasing degree of which in observation group was significantly higher than that in control group(P<0.01).Compared before treatment,the NIHSS scores in two groups were significantly decreased after treatment(P<0.01),and the decreasing degree of NIHSS score in observation group was significantly higher than that in control group(P<0.01).The total efficiency rates in observation group and control group were 89.55% and 69.84%,respectively,and the treatment effect in observation group was significantly higher than that in control group(P<0.01).The incidences of adverse reaction in observation and control group were 7.46% and 1.59%,respectively,the difference of which was not statistically significant(P>0.05).Before treatment,the high shear viscosity effected significantly on the efficacy(P<0.05,OR=0.643,OR 95%CI:0.442-1.241).Conclusions: Human serum albumin in treating the progressive cerebral infarction is safe and effective,but which is affected by the blood viscosity,and worthy of clinic application.
Objective: To explore the clinical efficacy of human albumin in the treatment of progressive cerebral infarction,and its affecting factors.Methods: Among 130 patients with progressive cerebral infarction,67 cases were treated with human serum albumin combined with symptomatic treatment(observation group),and 63 cases were treated with symptomatic treatment(control group).The blood viscosity,National Institutes of Health Stroke Scale(NIHSS) score,efficacy and adverse reaction between two groups were compared after 10 days of treatment.The affecting factors of curative efficacy were analyzed using the logistics regression.Results: Compared before treatment,the high,middle and low shear viscosity in two groups were significantly decreased after treatment(P<0.01),and the decreasing degree of which in observation group was significantly higher than that in control group(P<0.01).Compared before treatment,the NIHSS scores in two groups were significantly decreased after treatment(P<0.01),and the decreasing degree of NIHSS score in observation group was significantly higher than that in control group(P<0.01).The total efficiency rates in observation group and control group were 89.55% and 69.84%,respectively,and the treatment effect in observation group was significantly higher than that in control group(P<0.01).The incidences of adverse reaction in observation and control group were 7.46% and 1.59%,respectively,the difference of which was not statistically significant(P>0.05).Before treatment,the high shear viscosity effected significantly on the efficacy(P<0.05,OR=0.643,OR 95%CI:0.442-1.241).Conclusions: Human serum albumin in treating the progressive cerebral infarction is safe and effective,but which is affected by the blood viscosity,and worthy of clinic application.
2016, 41(8): 1064-1067.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.028
Abstract:
Objective: To investigate the clinical effects of modified nasal hill path frontal sinus correction surgery combined with all or part middle turbinate resection in the treatment of refractory sinusitis(RRS).Methods: Forty-two RRS patients were treated with modified nasal hill path frontal sinus correction surgery combined with all or part middle turbinate resection.Among the patients,26 cases with nasal septum deflection were treated with traditional correction resection under endoscopy,and 16 cases with allergic rhinitis were treated with the mucosa electrocoagulation.The clinical symptoms and quality of life in all patients between before and after treatment were compared.Results: The visual analogue scale(VAS) scores of nasal obstruction,rhinorrhea,olfactory loss or disorder and facial pain or oppress sense in of patients at post-operative 1 and 6 months were significantly lower than those in pre-operation(P<0.01).The total scores of SNOT-20,somatic symptom score and mental function score of patients at post-operative 1 and 6 months were significantly lower than those in pre-operation(P<0.01).The nasal mucocilia transfer rate(MTR) value of patients at post-operative 1 and 6 months were significantly lower than those in pre-operation(P<0.01).After the operation,the healing in 17 cases(40.48%),improvement in 21 cases(50.00%) and ineffectiveness in 4 cases(9.52%) were identified.Conclusions: The modified nasal hill path frontal sinus correction surgery combined with all or part middle turbinate resection in treating the RRS can significantly improve the clinical symptoms,the effect of which is good.
Objective: To investigate the clinical effects of modified nasal hill path frontal sinus correction surgery combined with all or part middle turbinate resection in the treatment of refractory sinusitis(RRS).Methods: Forty-two RRS patients were treated with modified nasal hill path frontal sinus correction surgery combined with all or part middle turbinate resection.Among the patients,26 cases with nasal septum deflection were treated with traditional correction resection under endoscopy,and 16 cases with allergic rhinitis were treated with the mucosa electrocoagulation.The clinical symptoms and quality of life in all patients between before and after treatment were compared.Results: The visual analogue scale(VAS) scores of nasal obstruction,rhinorrhea,olfactory loss or disorder and facial pain or oppress sense in of patients at post-operative 1 and 6 months were significantly lower than those in pre-operation(P<0.01).The total scores of SNOT-20,somatic symptom score and mental function score of patients at post-operative 1 and 6 months were significantly lower than those in pre-operation(P<0.01).The nasal mucocilia transfer rate(MTR) value of patients at post-operative 1 and 6 months were significantly lower than those in pre-operation(P<0.01).After the operation,the healing in 17 cases(40.48%),improvement in 21 cases(50.00%) and ineffectiveness in 4 cases(9.52%) were identified.Conclusions: The modified nasal hill path frontal sinus correction surgery combined with all or part middle turbinate resection in treating the RRS can significantly improve the clinical symptoms,the effect of which is good.
2016, 41(8): 1076-1078.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.033
Abstract:
Objective: To evaluate the curative effects of the intermittent gas injection combined with abdominal massage after fixation of lower limb in the treatment of intussusception in children.Methods: The intussusception in 95 children were treated using JS-628 type computer remote control intussusception reduction instrument.Forty children from Dec.2011 to Oct.2012 and 55 children from Nov.2012 to Nov.2013 were divided into the group A and group B,respectively.The group A and group B were treated with the single gas enema and intermittent gas injection combined with abdominal massage after fixation of lower limb,respectively.Results: The success rate and reduction average time in group A and group B were 85.0% & 98.2%,and 15 min & 12 min,respectively.No enterobrosis in two groups were found.Conclusions: The intermittent gas injection combined with abdominal massage after fixation of lower limb can improve the success rate of reduction of intussusception,and decrease the reduction time.
Objective: To evaluate the curative effects of the intermittent gas injection combined with abdominal massage after fixation of lower limb in the treatment of intussusception in children.Methods: The intussusception in 95 children were treated using JS-628 type computer remote control intussusception reduction instrument.Forty children from Dec.2011 to Oct.2012 and 55 children from Nov.2012 to Nov.2013 were divided into the group A and group B,respectively.The group A and group B were treated with the single gas enema and intermittent gas injection combined with abdominal massage after fixation of lower limb,respectively.Results: The success rate and reduction average time in group A and group B were 85.0% & 98.2%,and 15 min & 12 min,respectively.No enterobrosis in two groups were found.Conclusions: The intermittent gas injection combined with abdominal massage after fixation of lower limb can improve the success rate of reduction of intussusception,and decrease the reduction time.
2016, 41(8): 1086-1088.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.037
Abstract:
Objective: To investigate the effects of optimization postural training on the coordination compliance and postoperative complications risk in patients scheduled by thyroid surgery.Methods: Eighty patients scheduled by thyroid surgery were randomly divided into the control group and observation group(40 cases each group).The control group and observation group were treated with conventional postural training and optimization postural training,respectively.The coordination compliance,healthy knowledge,postoperative SF-36 score,postoperative complications and nursing satisfaction between two groups were compared.Results: The coordination compliance,healthy knowledge,postoperative SF-36 score and nursing satisfaction in observation group were higher than those in control group(P<0.05 to P<0.01).The incidences of the postoperative headache,nausea and vomiting and waist back pain in observation group were lower than those in control group(P<0.05 to P<0.01).Conclusions: The optimization postural training in nursing the patients scheduled by thyroid surgery can effectively improve the coordination compliance,healthy knowledge,quality of life and nurse-patient relationship,reduce the postoperative complications risk,and the clinical effects of which are better than those of conventional postural training.
Objective: To investigate the effects of optimization postural training on the coordination compliance and postoperative complications risk in patients scheduled by thyroid surgery.Methods: Eighty patients scheduled by thyroid surgery were randomly divided into the control group and observation group(40 cases each group).The control group and observation group were treated with conventional postural training and optimization postural training,respectively.The coordination compliance,healthy knowledge,postoperative SF-36 score,postoperative complications and nursing satisfaction between two groups were compared.Results: The coordination compliance,healthy knowledge,postoperative SF-36 score and nursing satisfaction in observation group were higher than those in control group(P<0.05 to P<0.01).The incidences of the postoperative headache,nausea and vomiting and waist back pain in observation group were lower than those in control group(P<0.05 to P<0.01).Conclusions: The optimization postural training in nursing the patients scheduled by thyroid surgery can effectively improve the coordination compliance,healthy knowledge,quality of life and nurse-patient relationship,reduce the postoperative complications risk,and the clinical effects of which are better than those of conventional postural training.
2016, 41(8): 1089-1091.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.038
Abstract:
Objective: To explore the effects of the nursing intervention and guiding significance of bispectral index BIS monitoring in coma patients after hematoma clearance.Methods: Eighty coma patients after craniotomy operation in ICU were randomly divided into the control group and observation group(40 cases each group).Two groups were treated with symptomatic therapy and 24 h reaction level scale(BIS) monitoring.The control group were nursed with the route method,and the observation group were nursed with strengthening the respiratory tract and catheter management.The prognosis condition,BIS value and respirator use time in different prognosis patients between two groups were compared.The correlation of BIS value with GCS score and RLS classification were analyzed.Results: All patients were followed up for half a year,the number of cases with good prognosis in observation group were significantly higher than that in control group(P<0.01).Among the observation group,the BIS value and respirator use time in patients with good prognosis were significantly higher and less than those in patient with poor prognosis,respectively(P<0.01).The correlation analysis showed that the BIS value was positive correlation with GCS score,and negative correlation with RLS classification(P<0.05).Conclusions: The effective nursing intervention can significantly improve the prognosis,and reduce the mortality.The BIS monitoring can effectively reflect the degree of cerebral dysfunction and prognosis of patients.
Objective: To explore the effects of the nursing intervention and guiding significance of bispectral index BIS monitoring in coma patients after hematoma clearance.Methods: Eighty coma patients after craniotomy operation in ICU were randomly divided into the control group and observation group(40 cases each group).Two groups were treated with symptomatic therapy and 24 h reaction level scale(BIS) monitoring.The control group were nursed with the route method,and the observation group were nursed with strengthening the respiratory tract and catheter management.The prognosis condition,BIS value and respirator use time in different prognosis patients between two groups were compared.The correlation of BIS value with GCS score and RLS classification were analyzed.Results: All patients were followed up for half a year,the number of cases with good prognosis in observation group were significantly higher than that in control group(P<0.01).Among the observation group,the BIS value and respirator use time in patients with good prognosis were significantly higher and less than those in patient with poor prognosis,respectively(P<0.01).The correlation analysis showed that the BIS value was positive correlation with GCS score,and negative correlation with RLS classification(P<0.05).Conclusions: The effective nursing intervention can significantly improve the prognosis,and reduce the mortality.The BIS monitoring can effectively reflect the degree of cerebral dysfunction and prognosis of patients.
2016, 41(8): 1092-1094.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.039
Abstract:
Objective: To observe the application effects of the Pediatric Critical Illness Score(PCIS) in hand-foot-mouth disease(HFMD).Methods: The "Pediatric Critical Illness Score of hand-foot-mouth disease(PCIS-HFMD)" was established according to the PCIS combined with the scores of body temperature and nervous system symptom.The severe HFMD children from 2014 to 2015 were divided into the control group(group A) and treatment group(group B).The control group and treatment group at admission were scored using PICS and PCIS-HFMD,respectively.The corresponding monitoring and treatment methods were implemented according to the scoring results.The clinical application effects of two kinds of scoring methods were analyzed.Results: The saving success rate in group B was higher than that in group A(P<0.05).The differences of the neurological sequelae incidence and case fatality rate between two groups were not statistically significant(P>0.05).Conclusions: The PCIS-HFMD can evaluate the severity of children with severe HFMD.The application of PCIS-HFMD in severe patients can improve the saving success rate,and reduce the incidence of neurological complications and mortality,which is worthy promotion in clinic.
Objective: To observe the application effects of the Pediatric Critical Illness Score(PCIS) in hand-foot-mouth disease(HFMD).Methods: The "Pediatric Critical Illness Score of hand-foot-mouth disease(PCIS-HFMD)" was established according to the PCIS combined with the scores of body temperature and nervous system symptom.The severe HFMD children from 2014 to 2015 were divided into the control group(group A) and treatment group(group B).The control group and treatment group at admission were scored using PICS and PCIS-HFMD,respectively.The corresponding monitoring and treatment methods were implemented according to the scoring results.The clinical application effects of two kinds of scoring methods were analyzed.Results: The saving success rate in group B was higher than that in group A(P<0.05).The differences of the neurological sequelae incidence and case fatality rate between two groups were not statistically significant(P>0.05).Conclusions: The PCIS-HFMD can evaluate the severity of children with severe HFMD.The application of PCIS-HFMD in severe patients can improve the saving success rate,and reduce the incidence of neurological complications and mortality,which is worthy promotion in clinic.
2016, 41(8): 1094-1096.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.040
Abstract:
Objective: To investigate the effects of multiform health education on the treatment compliance,efficacy and quality of life of cerebral stroke patients in recovery period.Methods: Ninety patients with cerebral stroke in recovery period were randomly divided into the conventional health education group(control group) and multiform health education group(observation group)(45 cases each group).The treatment compliance,efficacy and quality of life between two groups were compared and evaluated before education and after 4 and 12 weeks of education.Results: The treatment compliance and quality of life after 4 and 12 weeks of education and efficacy after 12 weeks of education in observation group were higher than those in control group(P<0.01).Conclusions: The effects of the multiform health education on treatment compliance,efficacy and quality of life in cerebral stroke patients in recovery period are great,which can lay the foundation in improving the rehabilitation exercise effect.
Objective: To investigate the effects of multiform health education on the treatment compliance,efficacy and quality of life of cerebral stroke patients in recovery period.Methods: Ninety patients with cerebral stroke in recovery period were randomly divided into the conventional health education group(control group) and multiform health education group(observation group)(45 cases each group).The treatment compliance,efficacy and quality of life between two groups were compared and evaluated before education and after 4 and 12 weeks of education.Results: The treatment compliance and quality of life after 4 and 12 weeks of education and efficacy after 12 weeks of education in observation group were higher than those in control group(P<0.01).Conclusions: The effects of the multiform health education on treatment compliance,efficacy and quality of life in cerebral stroke patients in recovery period are great,which can lay the foundation in improving the rehabilitation exercise effect.
2016, 41(8): 1097-1098,1101.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.041
Abstract:
Objective: To investigate the effects of coping efficacy on procrastination behavior of nurse in emergency department.Methods: The coping efficacy of 80 nurses in emergency department were investigated,and divided into high efficacy group and low efficacy group according to the efficiency score.The procrastination levels in two groups were evaluated using the procrastination scale.Results: The total score of coping efficacy and individual ability score of nurses in emergency department were significantly higher than those in national norm(P<0.01).The high efficacy in 45 cases and low efficacy in 35 cases were identified according to the efficacy score.The score of procrastination scale and incidence of procrastination in high efficacy group were less than those in low efficacy group(P<0.01 and P<0.05).Conclusions: The procrastination behavior is found in emergency nurses,which can affect the procrastination behavior.The psychological status and coping measures in emergency nurses should be paid attention to.
Objective: To investigate the effects of coping efficacy on procrastination behavior of nurse in emergency department.Methods: The coping efficacy of 80 nurses in emergency department were investigated,and divided into high efficacy group and low efficacy group according to the efficiency score.The procrastination levels in two groups were evaluated using the procrastination scale.Results: The total score of coping efficacy and individual ability score of nurses in emergency department were significantly higher than those in national norm(P<0.01).The high efficacy in 45 cases and low efficacy in 35 cases were identified according to the efficacy score.The score of procrastination scale and incidence of procrastination in high efficacy group were less than those in low efficacy group(P<0.01 and P<0.05).Conclusions: The procrastination behavior is found in emergency nurses,which can affect the procrastination behavior.The psychological status and coping measures in emergency nurses should be paid attention to.
2016, 41(8): 1099-1101.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.042
Abstract:
Objective: To investigate the effects of nursing intervention on the treatment of half facial spasm with the facial nerve vertical comb.Methods: Eighty half facial spasm patients treated with the facial nerve vertical comb were divided into the control group and observation group(40 cases each group).The control group and observation group were nursed with routine method and nursing intervention,respectively.The facial nerve function,anxiety and depression between two groups were compared.Results: The ratios of level Ⅰfacial nerve function in control group and observation group were 37.50% and 57.50%,respectively,the difference of which was not statistically significant(P>0.05).The differences of the SAS and SDS scores before intervention between two groups were not statistically significant(P>0.05).Compared before intervention,the SAS and SDS scores in two groups significantly decreased after intervention(P<0.01),and the decreasing degrees of the SAS and SDS scores in observation group were more significant(P<0.01).Conclusions: The nursing intervention in the treatment of half facial spasm with the facial nerve vertical comb can effectively alleviate the anxiety and depression,and improve the curative effect,which is worthy of popularization and application.
Objective: To investigate the effects of nursing intervention on the treatment of half facial spasm with the facial nerve vertical comb.Methods: Eighty half facial spasm patients treated with the facial nerve vertical comb were divided into the control group and observation group(40 cases each group).The control group and observation group were nursed with routine method and nursing intervention,respectively.The facial nerve function,anxiety and depression between two groups were compared.Results: The ratios of level Ⅰfacial nerve function in control group and observation group were 37.50% and 57.50%,respectively,the difference of which was not statistically significant(P>0.05).The differences of the SAS and SDS scores before intervention between two groups were not statistically significant(P>0.05).Compared before intervention,the SAS and SDS scores in two groups significantly decreased after intervention(P<0.01),and the decreasing degrees of the SAS and SDS scores in observation group were more significant(P<0.01).Conclusions: The nursing intervention in the treatment of half facial spasm with the facial nerve vertical comb can effectively alleviate the anxiety and depression,and improve the curative effect,which is worthy of popularization and application.
2016, 41(8): 1109-1111,1114.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.046
Abstract:
Objective: To know the influencing factors of the local villager health by interdisciplinary service-learning practice,and investigate the effects of service-learning on professional knowledge and skills in medical College students.Methods: The service-learning practice in 30 undergraduate students from clinical medicine,nursing,and pharmacology were implemented for 3 weeks according to the preparation,action,reflection and evaluation procedures.The learning effects were analyzed by reflecting writing after providing health service for local villagers.Results: The diet,drug and chronic disease were the key problems for detrimental to the health of villagers,targeted health education was implentmented for villagers.The reflecting writing of students showed that the service-learning improved the respect and communication in different specialities,enhanced professional knowledge and practical skills,and increased confidence and motivation in cooperating with other majors.Conclusions: The interprofessional service-learning practice can contribute to improve the professional knowledge and skills of students,which can be applied in the future medical education.
Objective: To know the influencing factors of the local villager health by interdisciplinary service-learning practice,and investigate the effects of service-learning on professional knowledge and skills in medical College students.Methods: The service-learning practice in 30 undergraduate students from clinical medicine,nursing,and pharmacology were implemented for 3 weeks according to the preparation,action,reflection and evaluation procedures.The learning effects were analyzed by reflecting writing after providing health service for local villagers.Results: The diet,drug and chronic disease were the key problems for detrimental to the health of villagers,targeted health education was implentmented for villagers.The reflecting writing of students showed that the service-learning improved the respect and communication in different specialities,enhanced professional knowledge and practical skills,and increased confidence and motivation in cooperating with other majors.Conclusions: The interprofessional service-learning practice can contribute to improve the professional knowledge and skills of students,which can be applied in the future medical education.
2016, 41(8): 1112-1114.
doi: 10.13898/j.cnki.issn.1000-2200.2016.08.047
Abstract:
Objective: To explore the effects of the investigation of community chronic disease guided by the concept of service learning on nursing undergraduates for providing the basis in developing the future nursing service learning programs.Methods: The data of the students reflection log were analyzed using the qualitative data analysis method.The experience and achievement of community chronic disease investigation in eight nursing undergraduates were understood.Results: The students had a positive attitude in service learning of community,which could improve the personal development,and played the positive role in future nursing work.Conclusions: The new teaching ideas combined with health education,psychological care and interpersonal communication should be applied in nursing practice education,which can establish the identity of the nursing profession students.
Objective: To explore the effects of the investigation of community chronic disease guided by the concept of service learning on nursing undergraduates for providing the basis in developing the future nursing service learning programs.Methods: The data of the students reflection log were analyzed using the qualitative data analysis method.The experience and achievement of community chronic disease investigation in eight nursing undergraduates were understood.Results: The students had a positive attitude in service learning of community,which could improve the personal development,and played the positive role in future nursing work.Conclusions: The new teaching ideas combined with health education,psychological care and interpersonal communication should be applied in nursing practice education,which can establish the identity of the nursing profession students.
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