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2016 Vol. 41, No. 7
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2016, 41(7): 841-844.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.001
Abstract:
Objective: To investigate the effects of calpain inhibitor Calpeptin on the migration of MDA-MB-231 breast cancer cells for providing an idea in treating the metastatic breast cancer.Methods: The effects of different concentrations of Calpeptin on the proliferation of MDA-MB-231 cells were determined using MTT assay.The effects of different concentrations of Calpeptin on the migration of MDA-MB-231 cells were detected using the wound healing assay and transwell migration assay.The effects of different concentrations of Calpeptin on the expression of matrix metalloproteinase-2(MMP-2) in MDA-MB-231 cells were detected using Western blot.Results: Calpeptin could suppress the proliferation of MDA-MB-231 breast cancer cells,the inhibiting effects of which increased with the increasing of the concentrations of Calpeptin(P<0.01).The migration ability of MDA-MB-231 cells decreased significantly after 24 h of treatment with Calpeptin(P<0.01).The result of Western blot showed that Calpeptin could down-regulate the expression of MMP-2 in MDA-MB-231 cells.Conclusions: Calpeptin can inhibit the migration of MDA-MB-231 cells,the mechanism of which may involve in the down-regulation of MMP-2.
Objective: To investigate the effects of calpain inhibitor Calpeptin on the migration of MDA-MB-231 breast cancer cells for providing an idea in treating the metastatic breast cancer.Methods: The effects of different concentrations of Calpeptin on the proliferation of MDA-MB-231 cells were determined using MTT assay.The effects of different concentrations of Calpeptin on the migration of MDA-MB-231 cells were detected using the wound healing assay and transwell migration assay.The effects of different concentrations of Calpeptin on the expression of matrix metalloproteinase-2(MMP-2) in MDA-MB-231 cells were detected using Western blot.Results: Calpeptin could suppress the proliferation of MDA-MB-231 breast cancer cells,the inhibiting effects of which increased with the increasing of the concentrations of Calpeptin(P<0.01).The migration ability of MDA-MB-231 cells decreased significantly after 24 h of treatment with Calpeptin(P<0.01).The result of Western blot showed that Calpeptin could down-regulate the expression of MMP-2 in MDA-MB-231 cells.Conclusions: Calpeptin can inhibit the migration of MDA-MB-231 cells,the mechanism of which may involve in the down-regulation of MMP-2.
2016, 41(7): 845-848,853.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.002
Abstract:
Objective: To observe the effects of cypermethrin on the oxidative damage and gene expression of nuclear factor erythroid-2-related factor 2(Nrf 2) mRNA in mice cerebellar tissue.Methods: Forty male Kunming mice were randomly divided into one negative control group and three cypermethrin infection groups.Three cypermethrin infection groups were infected by 5,10 and 20 mg/kg of cypermethrin gavage,once daily for three weeks,respectively.The contents of MDA,GSH-Px,T-SOD and CAT and MDA were measured in cerebellar tissue.The mRNA and protein expressions of Nrf2 in cerebellar tissue were detected using reverse transcription polymerase chain reaction(RT-PCR) and immunohistochemistry(IHC),respectively.Results: With the dose of cypermethrin increasing,the level of MDA increased,the levels of GSH-Px,T-SOD and CAT decreased in cerebellar tissue,and the differences of whose between the cypermethrin infection group and control group were statistically significant(P<0.01).The immunohistochemistry result showed that the positive expression of Nrf2 in nucleus increased in cerebellar tissue with the dose of cypermethrin increasing,the difference of which between the cypermethrin infection group and control group were statistically significant(P<0.01).The positive expression of Nrf2 in nucleus in high-dose cypermethrin infection group was higher than that in low-dose cypermethrin infection group(P<0.01).The RT-PCR results showed that the optical density value of Nrf2 increased in cerebellar tissue with the dose of cypermethrin increasing,the difference of which between the cypermethrin infection group and control group were statistically significant(P<0.01).The mRNA expression level of Nrf2 in high-dose cypermethrin infection group was higher than that in low-dose cypermethrin infection group(P<0.01).Conclusions: The cypermethrin infection can lead to the oxidative damage in cerebellar tissue and induce the translocation of Nrf2 from the cytoplasm to the nucleus,which can strength the antioxidative capacity of brain tissue.
Objective: To observe the effects of cypermethrin on the oxidative damage and gene expression of nuclear factor erythroid-2-related factor 2(Nrf 2) mRNA in mice cerebellar tissue.Methods: Forty male Kunming mice were randomly divided into one negative control group and three cypermethrin infection groups.Three cypermethrin infection groups were infected by 5,10 and 20 mg/kg of cypermethrin gavage,once daily for three weeks,respectively.The contents of MDA,GSH-Px,T-SOD and CAT and MDA were measured in cerebellar tissue.The mRNA and protein expressions of Nrf2 in cerebellar tissue were detected using reverse transcription polymerase chain reaction(RT-PCR) and immunohistochemistry(IHC),respectively.Results: With the dose of cypermethrin increasing,the level of MDA increased,the levels of GSH-Px,T-SOD and CAT decreased in cerebellar tissue,and the differences of whose between the cypermethrin infection group and control group were statistically significant(P<0.01).The immunohistochemistry result showed that the positive expression of Nrf2 in nucleus increased in cerebellar tissue with the dose of cypermethrin increasing,the difference of which between the cypermethrin infection group and control group were statistically significant(P<0.01).The positive expression of Nrf2 in nucleus in high-dose cypermethrin infection group was higher than that in low-dose cypermethrin infection group(P<0.01).The RT-PCR results showed that the optical density value of Nrf2 increased in cerebellar tissue with the dose of cypermethrin increasing,the difference of which between the cypermethrin infection group and control group were statistically significant(P<0.01).The mRNA expression level of Nrf2 in high-dose cypermethrin infection group was higher than that in low-dose cypermethrin infection group(P<0.01).Conclusions: The cypermethrin infection can lead to the oxidative damage in cerebellar tissue and induce the translocation of Nrf2 from the cytoplasm to the nucleus,which can strength the antioxidative capacity of brain tissue.
2016, 41(7): 849-853.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.003
Abstract:
Objective: To investigate the effect of LncRNA GAS5 on prolification,migration and invation in breast cancer cells.Methods: To achieve our goal,we used qRT-PCR assay to detect the expression of LncRNA GAS5 in breast cancer SKBR-3,MDA-MB-231 and MCF-7 cells;SRB assay was used to measure the prolification ability of breast cancer cells;Wound healing and Transwell assay was used to dentect the ability of invation and migration in breast cancer cells.Results: Among the three breast cancer cell lines,the expression level of LncRNA GAS5 in SKBR-3 cell is lowest and the expression level of LncRNA GAS5 in MCF-7 cell is highest(P<0.01).After transfected MCF-7 or SKBR-3 cells with si-GAS5 or pcDNA-GAS5-vertor,the expression level of LncRNA GAS5 in MCF-7 cells is down-regulated and in SKBR-3 cells is up-regulated(P<0.01),depletion of LncRNA GAS5,the prolification,invation and migration ability of MCF-7 cells is increased(P<0.01).Overexpression of LncRNA GAS5 made the prolification,invation and migration ability of SKBR-3 cells decreased(P<0.01).Conclusions: lncRNA GAS5 is a novel molecule involved in breast cancer progression,which provide a potential therapeutic target.
Objective: To investigate the effect of LncRNA GAS5 on prolification,migration and invation in breast cancer cells.Methods: To achieve our goal,we used qRT-PCR assay to detect the expression of LncRNA GAS5 in breast cancer SKBR-3,MDA-MB-231 and MCF-7 cells;SRB assay was used to measure the prolification ability of breast cancer cells;Wound healing and Transwell assay was used to dentect the ability of invation and migration in breast cancer cells.Results: Among the three breast cancer cell lines,the expression level of LncRNA GAS5 in SKBR-3 cell is lowest and the expression level of LncRNA GAS5 in MCF-7 cell is highest(P<0.01).After transfected MCF-7 or SKBR-3 cells with si-GAS5 or pcDNA-GAS5-vertor,the expression level of LncRNA GAS5 in MCF-7 cells is down-regulated and in SKBR-3 cells is up-regulated(P<0.01),depletion of LncRNA GAS5,the prolification,invation and migration ability of MCF-7 cells is increased(P<0.01).Overexpression of LncRNA GAS5 made the prolification,invation and migration ability of SKBR-3 cells decreased(P<0.01).Conclusions: lncRNA GAS5 is a novel molecule involved in breast cancer progression,which provide a potential therapeutic target.
2016, 41(7): 854-856,860.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.004
Abstract:
Objective: To discuss the sensitivity and feasibility of Montreal Cognitive Assessment(MoCA) and Mini-Mental State Examination(MMSE) in evaluating the mild cognitive impairment(MCI) of patients with Parkinson's disease(PD).Methods: Sixty PD patients and 30 control patients were evaluated using the MoCA and MMSE.Results: The difference of evaluation result of MoCA and MMSE between the PD group and control group was statistically significant(P<0.05).The scores of MoCA and MMSE in patients with light,medium and severe score of UPDRS were significantly lower than those in control group,and the more severe the disease was,the lower the scores of MoCA and MMSE were(P<0.01).The scores of MoCA and MMSE in patients with satge 1 to 5 of Hoehn-Yahr staging were significantly lower than that in control group(P<0.01);and the differences of the scores of MoCA and MMSE in patients with satge 1 to 5 were statistically significant(P<0.01).The MoCA scores of the space/executive function,abstract ability and memory in PD group were significantly lower than those in control group.Conclusions: The application of MoCA combined with MMSE can be beneficial for early finding the MCI in PD patients,and the sensitivity of MoCA in space/executive function,abstract ability and memory are better than that of MMSE.MoCA can provide the basis in early finding and nonivasive screening the PD patients with mild cognitive impairment.
Objective: To discuss the sensitivity and feasibility of Montreal Cognitive Assessment(MoCA) and Mini-Mental State Examination(MMSE) in evaluating the mild cognitive impairment(MCI) of patients with Parkinson's disease(PD).Methods: Sixty PD patients and 30 control patients were evaluated using the MoCA and MMSE.Results: The difference of evaluation result of MoCA and MMSE between the PD group and control group was statistically significant(P<0.05).The scores of MoCA and MMSE in patients with light,medium and severe score of UPDRS were significantly lower than those in control group,and the more severe the disease was,the lower the scores of MoCA and MMSE were(P<0.01).The scores of MoCA and MMSE in patients with satge 1 to 5 of Hoehn-Yahr staging were significantly lower than that in control group(P<0.01);and the differences of the scores of MoCA and MMSE in patients with satge 1 to 5 were statistically significant(P<0.01).The MoCA scores of the space/executive function,abstract ability and memory in PD group were significantly lower than those in control group.Conclusions: The application of MoCA combined with MMSE can be beneficial for early finding the MCI in PD patients,and the sensitivity of MoCA in space/executive function,abstract ability and memory are better than that of MMSE.MoCA can provide the basis in early finding and nonivasive screening the PD patients with mild cognitive impairment.
2016, 41(7): 857-860.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.005
Abstract:
Objective: To explore the clinical effects of the balloon dilation technology combined with electronic laryngoscope in the treatment of maxillary sinus cyst.Methods: Twenty-six patients with maxillary sinus cyst were treated with electronic laryngoscope inserting into the maxillary sinus through the expanded maxillary sinus ostium after maxillary sinus ostium balloon dilation under nasal endoscopy,and the maxillary sinus cyst was resected using biopsy forceps.The patients were followed up for 6 to 12 months,and clinical efficacy was evaluated.Results: The maxillary sinus cyst in 26 patients were successfully resected.No postoperative nasal bleeding,nasal adhesion and nasolacrimal duct injury were found.The postoperative recurrence of maxillary sinus cyst in 1 case was identified,who was cured using electronic laryngoscope inserting into the maxillary sinus resecting again.Conclusions: Balloon dilation technology combined with electronic laryngoscope in the treatment of maxillary sinus cyst can retain the complete anatomy structure,which is simple operation,small trauma,less pain,rapid recovery,fewer complication and an ideal operation method in the treatment of maxillary sinus cyst.
Objective: To explore the clinical effects of the balloon dilation technology combined with electronic laryngoscope in the treatment of maxillary sinus cyst.Methods: Twenty-six patients with maxillary sinus cyst were treated with electronic laryngoscope inserting into the maxillary sinus through the expanded maxillary sinus ostium after maxillary sinus ostium balloon dilation under nasal endoscopy,and the maxillary sinus cyst was resected using biopsy forceps.The patients were followed up for 6 to 12 months,and clinical efficacy was evaluated.Results: The maxillary sinus cyst in 26 patients were successfully resected.No postoperative nasal bleeding,nasal adhesion and nasolacrimal duct injury were found.The postoperative recurrence of maxillary sinus cyst in 1 case was identified,who was cured using electronic laryngoscope inserting into the maxillary sinus resecting again.Conclusions: Balloon dilation technology combined with electronic laryngoscope in the treatment of maxillary sinus cyst can retain the complete anatomy structure,which is simple operation,small trauma,less pain,rapid recovery,fewer complication and an ideal operation method in the treatment of maxillary sinus cyst.
2016, 41(7): 861-862,865.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.006
Abstract:
Objective: To explore the curative effects of alprostadil combined with telmisartan in the treatment of diabetic nephropathy(DN),and its effect on TNF-α and IL-6.Methods: One hundred and twenty with diabetic nephropathy were randomly divided into two groups(60 cases each group).The levels of fasting blood glucose(FBG),postprandial 2h plasma glucose(2hPBG),systolic blood pressure(SBP),diastolic pressure(DBP),urea(BUN),serum creatinine(Scr),urinary albumin,24h total urinary albumin,serum TNF-α and IL-6 between pretreatment and after 4 weeks of treatment were compared.Results: After treatment,all indicators in two groups decreased,the fall of the levels of 2hPBG,SBP,DBP,Mb,BUN,Scr,Mb,24hTUB,TNF-α and IL-6 in observation group were more significant than those in control group(P<0.01).Conclusions: The treatment of diabetic nephropathy with alprostadil combined with telmisartan has significantly effects,the effect of the joint drugs is better than that in single drug,which can effectively control and delay further development of disease.
Objective: To explore the curative effects of alprostadil combined with telmisartan in the treatment of diabetic nephropathy(DN),and its effect on TNF-α and IL-6.Methods: One hundred and twenty with diabetic nephropathy were randomly divided into two groups(60 cases each group).The levels of fasting blood glucose(FBG),postprandial 2h plasma glucose(2hPBG),systolic blood pressure(SBP),diastolic pressure(DBP),urea(BUN),serum creatinine(Scr),urinary albumin,24h total urinary albumin,serum TNF-α and IL-6 between pretreatment and after 4 weeks of treatment were compared.Results: After treatment,all indicators in two groups decreased,the fall of the levels of 2hPBG,SBP,DBP,Mb,BUN,Scr,Mb,24hTUB,TNF-α and IL-6 in observation group were more significant than those in control group(P<0.01).Conclusions: The treatment of diabetic nephropathy with alprostadil combined with telmisartan has significantly effects,the effect of the joint drugs is better than that in single drug,which can effectively control and delay further development of disease.
2016, 41(7): 863-865.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.007
Abstract:
Objective: To explore the expressions of the different genotypes of Helicobacter pylori(Hp) in patients with type 2 diabetesmellitus(T2DM).Methods: One hundred and seventy patients with T2DM and 170 non-T2DM were divided into the observation group and control group,respectively.The fasting blood glucose,body mass index,ratio of waist to hip,Hp infection,genotypes of cytotoxin associated protein and vacuolating cytotoxin associated protein of Hp,and the levels of glycated haemoglobin,fasting insulin and insulin sensitivity index between two groups were compared and analyzed.Results: The fasting blood glucose,body mass index,ratio waist to hip,infection rate of Hp,and the positive rates of cytotoxin associated protein and vacuolating cytotoxin associated protein of Hp in observation group were significantly higher than those in control group(P<0.01).The levels of glycated haemoglobin and fasting insulin in observation group were significantly higher than those in control group,the insulin sensitivity index in observation group was significantly lower than that in control group(P<0.01).Conclusions: The genotypes of cytotoxin associated protein and vacuolating cytotoxin associated protein of Hp play an important role in the occurrence process of T2DM.
Objective: To explore the expressions of the different genotypes of Helicobacter pylori(Hp) in patients with type 2 diabetesmellitus(T2DM).Methods: One hundred and seventy patients with T2DM and 170 non-T2DM were divided into the observation group and control group,respectively.The fasting blood glucose,body mass index,ratio of waist to hip,Hp infection,genotypes of cytotoxin associated protein and vacuolating cytotoxin associated protein of Hp,and the levels of glycated haemoglobin,fasting insulin and insulin sensitivity index between two groups were compared and analyzed.Results: The fasting blood glucose,body mass index,ratio waist to hip,infection rate of Hp,and the positive rates of cytotoxin associated protein and vacuolating cytotoxin associated protein of Hp in observation group were significantly higher than those in control group(P<0.01).The levels of glycated haemoglobin and fasting insulin in observation group were significantly higher than those in control group,the insulin sensitivity index in observation group was significantly lower than that in control group(P<0.01).Conclusions: The genotypes of cytotoxin associated protein and vacuolating cytotoxin associated protein of Hp play an important role in the occurrence process of T2DM.
2016, 41(7): 866-867,870.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.008
Abstract:
Objective: To investigate the correlations between the degree of coronary lesion and levels of serum uric acid(UA),brain natriuretic peptide(BNP) and high sensitivity C-reactive protein(hs-CRP) in patients with coronary artery disease(CHD).Methods: The coronary angiography in 72 suspect CHD cases were examined,and 52 pateints with CHD were diagnosed.The 52 CHD patients were divided into the acute myocardial infarction group(AMI group,23 cases) and unstable angina pectoris group(UAP group,29 cases).The AMI group with thrombolytic therapy indication and without contraindication were treated with intravenous urokinase.Fifty-two CHD cases were divided into the one-vessel disease group(18 cases),two-vessel disease group(19 cases) and multiple-vessel disease group(15 cases) according to the lesion degree detected by coronary angiography.The 20 cases without CHD were set as the control group.The serum levels of UA,BNP and hs-CRP in different groups were compared.Results: The serum levels of UA,BNP and hs-CRP in AMI group were significantly higher than those in UAP group and control group(P<0.05 to P<0.01).The serum levels of UA and BNP in UAP group were significantly higher than those in control group(P<0.01).The serum levels of UA,BNP and hs-CRP in two- and multiple-vessel disease groups were obviously higher than those in one-vessel disease group(P<0.01),the serum levels of UA,BNP and hs-CRP in multiple-vessel disease group were higher than those in two-vessel disease group(P<0.05 to P<0.01).Conclusions: The serum levels of UA,BNP and hs-CRP have certain correlations with the lesion degree of coronary in CHD patients,and those indexes can be used to evaluate the degree of myocardial ischemia,and acted as the indexes of risk stratification.
Objective: To investigate the correlations between the degree of coronary lesion and levels of serum uric acid(UA),brain natriuretic peptide(BNP) and high sensitivity C-reactive protein(hs-CRP) in patients with coronary artery disease(CHD).Methods: The coronary angiography in 72 suspect CHD cases were examined,and 52 pateints with CHD were diagnosed.The 52 CHD patients were divided into the acute myocardial infarction group(AMI group,23 cases) and unstable angina pectoris group(UAP group,29 cases).The AMI group with thrombolytic therapy indication and without contraindication were treated with intravenous urokinase.Fifty-two CHD cases were divided into the one-vessel disease group(18 cases),two-vessel disease group(19 cases) and multiple-vessel disease group(15 cases) according to the lesion degree detected by coronary angiography.The 20 cases without CHD were set as the control group.The serum levels of UA,BNP and hs-CRP in different groups were compared.Results: The serum levels of UA,BNP and hs-CRP in AMI group were significantly higher than those in UAP group and control group(P<0.05 to P<0.01).The serum levels of UA and BNP in UAP group were significantly higher than those in control group(P<0.01).The serum levels of UA,BNP and hs-CRP in two- and multiple-vessel disease groups were obviously higher than those in one-vessel disease group(P<0.01),the serum levels of UA,BNP and hs-CRP in multiple-vessel disease group were higher than those in two-vessel disease group(P<0.05 to P<0.01).Conclusions: The serum levels of UA,BNP and hs-CRP have certain correlations with the lesion degree of coronary in CHD patients,and those indexes can be used to evaluate the degree of myocardial ischemia,and acted as the indexes of risk stratification.
2016, 41(7): 868-870.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.009
Abstract:
Objective: To investigate the relationships between the disease exacerbations and circadian rhythms in patients with chronic obstructive pulmonary disease(COPD).Methods: One hundred and fifty-four patients with COPD were followed up for 3 years.The general condition and exacerbations situation in all patients were recorded.The relationships between smoking,age,sexuality,circadian rhythms and disease exacerbations were analyzed.Results: The acute exacerbation times in 154 cases were 1 401 times,which included the 512 times of awakening type(36.5%) and 889 times of sleep type(63.5%).One hundred and fifty-four cases included the acute exacerbation sleep type COPD in 82 cases(53.2%),acute exacerbation awakening type COPD in 32 cases(20.8%) and acute exacerbation diffuse type COPD in 40 cases(26.0%).The exacerbations COPD in night was most likely to occur in patients with more than or equal to 70 years,smoking male with less than or equal to 70 years and non-smoking female(P<0.05 to P<0.01).Conclusions: The exacerbations of COPD exists the circadian rhythms,the occurrence of which is prone to at night,in sleep type patients,and especially for smoking old male.
Objective: To investigate the relationships between the disease exacerbations and circadian rhythms in patients with chronic obstructive pulmonary disease(COPD).Methods: One hundred and fifty-four patients with COPD were followed up for 3 years.The general condition and exacerbations situation in all patients were recorded.The relationships between smoking,age,sexuality,circadian rhythms and disease exacerbations were analyzed.Results: The acute exacerbation times in 154 cases were 1 401 times,which included the 512 times of awakening type(36.5%) and 889 times of sleep type(63.5%).One hundred and fifty-four cases included the acute exacerbation sleep type COPD in 82 cases(53.2%),acute exacerbation awakening type COPD in 32 cases(20.8%) and acute exacerbation diffuse type COPD in 40 cases(26.0%).The exacerbations COPD in night was most likely to occur in patients with more than or equal to 70 years,smoking male with less than or equal to 70 years and non-smoking female(P<0.05 to P<0.01).Conclusions: The exacerbations of COPD exists the circadian rhythms,the occurrence of which is prone to at night,in sleep type patients,and especially for smoking old male.
2016, 41(7): 871-873.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.010
Abstract:
Objective: To investigate the effects of Xuefuzhuyu capsule(XFZYC) on the expression of related-hormone of intrauterine adhesion and its clinical efficacy.Methods: The patients with amenorrhea or scanty menstruation from "The First Hospital of Traditional Chinese and Western Medicine of Beijing" from Jan 2013 to Nov 2014 were diagnosed by hysteroscopy,and their intrauterine adhesion was separated.Two hundred and twenty women placed with the contraceptive ring were randomly divided into the control group and observation group(110 cases each group).The control group and observation group were treated with 2 mg of estradiol valerate and XFZYC by oral,once a day,respectively.One hundred healthy women were set as the healthy group.The postoperative volume of menstrual flow and intrauterine condition under hysteroscopy in all groups were observed.The levels of luteinizing hormone(LH),follicle stimulating hormone,estradiol,progesterone,prolactin and testosterone,and the expressions of estrogen receptor(ER) and progesterone receptor(PR) were detected.Results: Among two groups,the drug use stopped within three months,and taking ring was successful.The total effective rates in the control group and observation were 74.55% and 98.18%,respectively,the difference of which was not statistically signifcant(P>0.05).The differences of the 6 stems hormone levels between two groups after treatment were not statistically signifcant(P>0.05).The expression of endometrium ER in two groups was higher than that in healthy women(P<0.05).Conclusions: The abnormal expression of endometrium ER and PR may be involved in the formation of intrauterine adhesion.The effect of XFZYC in the treatment of intrauterine adhesion is significant.
Objective: To investigate the effects of Xuefuzhuyu capsule(XFZYC) on the expression of related-hormone of intrauterine adhesion and its clinical efficacy.Methods: The patients with amenorrhea or scanty menstruation from "The First Hospital of Traditional Chinese and Western Medicine of Beijing" from Jan 2013 to Nov 2014 were diagnosed by hysteroscopy,and their intrauterine adhesion was separated.Two hundred and twenty women placed with the contraceptive ring were randomly divided into the control group and observation group(110 cases each group).The control group and observation group were treated with 2 mg of estradiol valerate and XFZYC by oral,once a day,respectively.One hundred healthy women were set as the healthy group.The postoperative volume of menstrual flow and intrauterine condition under hysteroscopy in all groups were observed.The levels of luteinizing hormone(LH),follicle stimulating hormone,estradiol,progesterone,prolactin and testosterone,and the expressions of estrogen receptor(ER) and progesterone receptor(PR) were detected.Results: Among two groups,the drug use stopped within three months,and taking ring was successful.The total effective rates in the control group and observation were 74.55% and 98.18%,respectively,the difference of which was not statistically signifcant(P>0.05).The differences of the 6 stems hormone levels between two groups after treatment were not statistically signifcant(P>0.05).The expression of endometrium ER in two groups was higher than that in healthy women(P<0.05).Conclusions: The abnormal expression of endometrium ER and PR may be involved in the formation of intrauterine adhesion.The effect of XFZYC in the treatment of intrauterine adhesion is significant.
2016, 41(7): 874-876.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.011
Abstract:
Objective: To compare the effects of transvaginal resection combined with uterine diverticulum neoplasty and uterine artery embolization in the treatment of caesarean scar pregnancy(CSP).Methods: The data of 30 patients with CSP were retrospectively analyzed.Twelve cases were treated with transvaginal resection combined with uterine diverticulum neoplasty,18 cases were treated with uterine artery embolization,methotrexate combined with curettage.The operative time,peroperative bleeding volume,postoperative recovery time of β-hCG,hospitalization time and cost,and complication between two techniques were compared.Results: The differences of the average operation and hospitalization time were not statistically significant(P>0.05).The taking embryo operation through transvaginal resection of lower uterine segment in 12 cases were successful,and no complication was found.The peroperative bleeding volume,postoperative recovery time of β-hCG,hospitalization cost were(55.2±15.5)mL,(15.8±3.5)d and(7 820.5±360.0) Yuan,respectively,which were less than those in the patients treated with uterine artery embolization(P<0.01).Among 18 cases treated with uterine artery embolization,1 case was treated with curettage.The scar broke during the operation,and which was excised and repaired.Conclusions: The treatment of CSP with the transvaginal resection combined with uterine diverticulum neoplasty is effective,safe,economic and quick recovery.
Objective: To compare the effects of transvaginal resection combined with uterine diverticulum neoplasty and uterine artery embolization in the treatment of caesarean scar pregnancy(CSP).Methods: The data of 30 patients with CSP were retrospectively analyzed.Twelve cases were treated with transvaginal resection combined with uterine diverticulum neoplasty,18 cases were treated with uterine artery embolization,methotrexate combined with curettage.The operative time,peroperative bleeding volume,postoperative recovery time of β-hCG,hospitalization time and cost,and complication between two techniques were compared.Results: The differences of the average operation and hospitalization time were not statistically significant(P>0.05).The taking embryo operation through transvaginal resection of lower uterine segment in 12 cases were successful,and no complication was found.The peroperative bleeding volume,postoperative recovery time of β-hCG,hospitalization cost were(55.2±15.5)mL,(15.8±3.5)d and(7 820.5±360.0) Yuan,respectively,which were less than those in the patients treated with uterine artery embolization(P<0.01).Among 18 cases treated with uterine artery embolization,1 case was treated with curettage.The scar broke during the operation,and which was excised and repaired.Conclusions: The treatment of CSP with the transvaginal resection combined with uterine diverticulum neoplasty is effective,safe,economic and quick recovery.
2016, 41(7): 877-878.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.012
Abstract:
Objective: To analyze the related factors of nerve injury after intraspinal anesthesia of puerpera.Methods: Three hundred and fifty puerperas treated with lower uterus cesarean section under intraspinal anesthesia were divided into the nerve injury group(40 cases) and non-nerve injury group(310 cases).The body weight,age,gestational age,preoperative comorbidities,different sense during anesthesia and edema during late pregnancy between groups were analyzed.Results: The differences of the age,height,body mass and gestational age between two groups were not statistically significant(P>0.05).The foreign body sensation rate in nerve injury group during anesthesia(80.0%) was significantly higher than that in non-nerve injury group(2.2%)(P<0.01).The rate of pregnancy edeman in nerve injury group(65.0%) was significantly higher than that in non-nerve injury group(6.5%)(P<0.01).Conclusions: The skilled and specification operation in intraspinal anesthesia can reduce the occurrence of postoperative nerve injury,foreign body sensation and maternal pregnancy edema.
Objective: To analyze the related factors of nerve injury after intraspinal anesthesia of puerpera.Methods: Three hundred and fifty puerperas treated with lower uterus cesarean section under intraspinal anesthesia were divided into the nerve injury group(40 cases) and non-nerve injury group(310 cases).The body weight,age,gestational age,preoperative comorbidities,different sense during anesthesia and edema during late pregnancy between groups were analyzed.Results: The differences of the age,height,body mass and gestational age between two groups were not statistically significant(P>0.05).The foreign body sensation rate in nerve injury group during anesthesia(80.0%) was significantly higher than that in non-nerve injury group(2.2%)(P<0.01).The rate of pregnancy edeman in nerve injury group(65.0%) was significantly higher than that in non-nerve injury group(6.5%)(P<0.01).Conclusions: The skilled and specification operation in intraspinal anesthesia can reduce the occurrence of postoperative nerve injury,foreign body sensation and maternal pregnancy edema.
2016, 41(7): 879-881.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.013
Abstract:
Objective: To explore the clinical effects of different doses of remifentanil on the spontaneous respiration in children under the sevoflurane anesthesia.Methods: Eighty children treated with inguinal hernia repair operation were randomly divided into the low dose group and high dose group according to the use dose of remifentanil(40 cases each group).The anesthesia in low dose group and high dose group were maintained using 0.03μg·kg-1·min-1 and 0.09μg·kg-1·min-1 of remifentanil,respectively.The respiration rate(RR),tidal volume(TV),minute ventilation(MV),partial pressure of carbon dioxide in endexpiratory gas(PCO2),mean arterial pressure(MBP) and heart rate(HR) were recorded at T0(intubating laryngeal mask airway),T1(after intravenous loading),T2(after 10 min of anesthesia),T3(after 15 min of anesthesia) and T4(extracting laryngeal mask).The occurrence of intraoperative anoxenia in two groups were analyzed.Results: The levels of RR and MV in two groups significantly decreased at T1(P<0.01),and the levels of RR and MV in low dose group at T2,T3 and T4 were significantly higher than those in high dose group(P<0.01).The levels of PCO2 in two groups significantly increased at T1,and the levels of PCO2 in low dose group at T2 and T3 were significantly lower than those in high dose group(P<0.01).The differences of the level change of VT,HR and MBP in two groups at each time point were statistically significant(P>0.05).The intraoperative anoxenia was not found in two groups.Conclusions: The effect of sevoflurane combined with low dose remifentanil in spontaneous respiration anesthesia in children is good,which can make the respiratory system more stable in children,and has application value in clinic.
Objective: To explore the clinical effects of different doses of remifentanil on the spontaneous respiration in children under the sevoflurane anesthesia.Methods: Eighty children treated with inguinal hernia repair operation were randomly divided into the low dose group and high dose group according to the use dose of remifentanil(40 cases each group).The anesthesia in low dose group and high dose group were maintained using 0.03μg·kg-1·min-1 and 0.09μg·kg-1·min-1 of remifentanil,respectively.The respiration rate(RR),tidal volume(TV),minute ventilation(MV),partial pressure of carbon dioxide in endexpiratory gas(PCO2),mean arterial pressure(MBP) and heart rate(HR) were recorded at T0(intubating laryngeal mask airway),T1(after intravenous loading),T2(after 10 min of anesthesia),T3(after 15 min of anesthesia) and T4(extracting laryngeal mask).The occurrence of intraoperative anoxenia in two groups were analyzed.Results: The levels of RR and MV in two groups significantly decreased at T1(P<0.01),and the levels of RR and MV in low dose group at T2,T3 and T4 were significantly higher than those in high dose group(P<0.01).The levels of PCO2 in two groups significantly increased at T1,and the levels of PCO2 in low dose group at T2 and T3 were significantly lower than those in high dose group(P<0.01).The differences of the level change of VT,HR and MBP in two groups at each time point were statistically significant(P>0.05).The intraoperative anoxenia was not found in two groups.Conclusions: The effect of sevoflurane combined with low dose remifentanil in spontaneous respiration anesthesia in children is good,which can make the respiratory system more stable in children,and has application value in clinic.
2016, 41(7): 882-883,886.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.014
Abstract:
Objective: To investigate the optimal anesthesia program and its effects during the course of high intensity focused ultrasound(HIFU)-knife in the treatment of hepatic hemangioma.Methods: Sixty patients with hepatic hemangioma were randomly divided into the control group and observation group.The control group and observation group were treated with conventional resection and HIFU-knife,respectively.The anesthesia program and clinical effects between two groups were compared and analyzed.Results: The stage ASA Ⅰ anesthesia effect in 52 cases were identified,the good rate of which was 86.7%.The operation time,recovery time and visual analogue scale scores in observation group were significantly better than those in control group(P<0.01).Conclusions: The treatment of hepatic hemangioma with HIFU-knife is effective and small trauma.The anesthesia during the operation can play positive effects on the operation,treatment and recovery of the disease.
Objective: To investigate the optimal anesthesia program and its effects during the course of high intensity focused ultrasound(HIFU)-knife in the treatment of hepatic hemangioma.Methods: Sixty patients with hepatic hemangioma were randomly divided into the control group and observation group.The control group and observation group were treated with conventional resection and HIFU-knife,respectively.The anesthesia program and clinical effects between two groups were compared and analyzed.Results: The stage ASA Ⅰ anesthesia effect in 52 cases were identified,the good rate of which was 86.7%.The operation time,recovery time and visual analogue scale scores in observation group were significantly better than those in control group(P<0.01).Conclusions: The treatment of hepatic hemangioma with HIFU-knife is effective and small trauma.The anesthesia during the operation can play positive effects on the operation,treatment and recovery of the disease.
2016, 41(7): 884-886.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.015
Abstract:
Objective: To investigate the correlation of bilirubin with the prognosis of ischemic stroke for providing the reference in judging the prognosis of ischemic stroke.Methods: Sixty patients with ischemic stroke and 60 healthy people were divided into the case group and control group,respectively.The levels of bilirubin between two groups were compared.After 2 weeks of treatment,the case group were subdivided into group A(symptom improvement) and group B(treatment failure or symptom aggravation),the levels of serum bilirubin between two groups were compared,and the correlation of indirect bilirubin with the max infarct diameter was analyzed.Results: At admission,the levels of the total bilirubin,direct bilirubin and indirect bilirubin in case group were higher than those in control group(P<0.05 to P<0.01).After 2 weeks of treatment,the levels of serum total bilirubin,direct bilirubin and indirect bilirubin in two groups decreased significantly(P<0.01),the levels of serum total bilirubin and indirect bilirubin in group A were significantly higher than those in group B(P< 0.01).After treatment,the max infarct diameter in group A was significantly less than that in group B,and the level of indirect bilirubin in group A was significantly higher than that in group B(P< 0.01).The max infarct diameters in group A and B were negatively correlation with the levels of indirect bilirubin(P<0.05).Conclusions: The serum bilirubin level increases in early ischemic stroke,the hyperbilirubinemia indicates the serious condition and poor prognosis.
Objective: To investigate the correlation of bilirubin with the prognosis of ischemic stroke for providing the reference in judging the prognosis of ischemic stroke.Methods: Sixty patients with ischemic stroke and 60 healthy people were divided into the case group and control group,respectively.The levels of bilirubin between two groups were compared.After 2 weeks of treatment,the case group were subdivided into group A(symptom improvement) and group B(treatment failure or symptom aggravation),the levels of serum bilirubin between two groups were compared,and the correlation of indirect bilirubin with the max infarct diameter was analyzed.Results: At admission,the levels of the total bilirubin,direct bilirubin and indirect bilirubin in case group were higher than those in control group(P<0.05 to P<0.01).After 2 weeks of treatment,the levels of serum total bilirubin,direct bilirubin and indirect bilirubin in two groups decreased significantly(P<0.01),the levels of serum total bilirubin and indirect bilirubin in group A were significantly higher than those in group B(P< 0.01).After treatment,the max infarct diameter in group A was significantly less than that in group B,and the level of indirect bilirubin in group A was significantly higher than that in group B(P< 0.01).The max infarct diameters in group A and B were negatively correlation with the levels of indirect bilirubin(P<0.05).Conclusions: The serum bilirubin level increases in early ischemic stroke,the hyperbilirubinemia indicates the serious condition and poor prognosis.
2016, 41(7): 887-890.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.016
Abstract:
Objective: To evaluate the efficacy and safety of recombinant human thrombopoietin(rhTPO) in the treatment of adult immune thrombocytopenia(ITP).Methods: Ten patients with ITP were treated with rhTPO.The platelet counts and adverse effects in all cases after treatment were observed.Results: The total response,which included the complete response(CR) and effectiveness(R),and CR rates in ITP patients were 80.0% and 70.0%,respectively.Among the new diagnosis of 6 cases,CR in 5 cases and non response(NR)in 1 case were found.Among the new diagnosis of 6 cases,CR in 1 case with persistent ITP,CR,R and NR in 1 case with chronic ITP,and NR in two cases were identified.Among the effective treatment patients,the platelet count was more than 30×109/L,the average time was 7.8 days,and the time of the platelet counts arriving at the normal value(100×109/L) was 12 days.After stopping the rhTPO,the platelet levels in 6 patients were normal,and the longest time of maintaining normal PLT level was 17 months.During the period of treatment with rhTPO,the finger end thromboembolism in 1 case was found,the patient was treated with stopping the rhTPO use and vasoactive drugs by oral.After treatment,the symptom disappeared,and no sequelae was found.Conclusions: The treatment of ITP with rhTPO is effective and safe,which can quickly help the patient cross the high risk of serious bleeding,reduce the amount of platelet transfusion,and has not serious adverse reactions.
Objective: To evaluate the efficacy and safety of recombinant human thrombopoietin(rhTPO) in the treatment of adult immune thrombocytopenia(ITP).Methods: Ten patients with ITP were treated with rhTPO.The platelet counts and adverse effects in all cases after treatment were observed.Results: The total response,which included the complete response(CR) and effectiveness(R),and CR rates in ITP patients were 80.0% and 70.0%,respectively.Among the new diagnosis of 6 cases,CR in 5 cases and non response(NR)in 1 case were found.Among the new diagnosis of 6 cases,CR in 1 case with persistent ITP,CR,R and NR in 1 case with chronic ITP,and NR in two cases were identified.Among the effective treatment patients,the platelet count was more than 30×109/L,the average time was 7.8 days,and the time of the platelet counts arriving at the normal value(100×109/L) was 12 days.After stopping the rhTPO,the platelet levels in 6 patients were normal,and the longest time of maintaining normal PLT level was 17 months.During the period of treatment with rhTPO,the finger end thromboembolism in 1 case was found,the patient was treated with stopping the rhTPO use and vasoactive drugs by oral.After treatment,the symptom disappeared,and no sequelae was found.Conclusions: The treatment of ITP with rhTPO is effective and safe,which can quickly help the patient cross the high risk of serious bleeding,reduce the amount of platelet transfusion,and has not serious adverse reactions.
2016, 41(7): 890-892.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.017
Abstract:
Objective: To investigate the clinical effects of the intensive care unit(ICU) optimization on cerebral resuscitation in patients with post-cardiac arrest syndrome(PCAS).Methods: Ninety patients with PCAS were randomly divided into the control group and observation group(45 cases each group).Two groups were treated with routine ICU nursing,while the observation group were additionally treated with optimization scheme.The clinical indicators,heart function improvement,nerve function recovery,mortality and incidence of complications between two groups were compared.Results: The differences of the ventilation and hospitalization time in intensive care unit and global end diastolic volume index between two groups were not statistically significant(P>0.05).The cardiac index in observation group after treatment was significantly lower than that in control group(P<0.01),while the good rate of nerve function recovery and mortality in observation group were significantly higher and lower than that in control group,respectively(P<0.05 and P<0.01).The difference of the incidence of complications between two groups was not statistically significant(P>0.05).Conclusions: The intensive care unit optimization treatment can significantly improve the cardiac function and nerve function,and reduce the mortality of the PCAS patients.
Objective: To investigate the clinical effects of the intensive care unit(ICU) optimization on cerebral resuscitation in patients with post-cardiac arrest syndrome(PCAS).Methods: Ninety patients with PCAS were randomly divided into the control group and observation group(45 cases each group).Two groups were treated with routine ICU nursing,while the observation group were additionally treated with optimization scheme.The clinical indicators,heart function improvement,nerve function recovery,mortality and incidence of complications between two groups were compared.Results: The differences of the ventilation and hospitalization time in intensive care unit and global end diastolic volume index between two groups were not statistically significant(P>0.05).The cardiac index in observation group after treatment was significantly lower than that in control group(P<0.01),while the good rate of nerve function recovery and mortality in observation group were significantly higher and lower than that in control group,respectively(P<0.05 and P<0.01).The difference of the incidence of complications between two groups was not statistically significant(P>0.05).Conclusions: The intensive care unit optimization treatment can significantly improve the cardiac function and nerve function,and reduce the mortality of the PCAS patients.
2016, 41(7): 893-896.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.018
Abstract:
Objective: To investigate the clinical effects of the low temperature radiofrequency ablation during nasal endoscopy in the improvement of nasal ventilation function of patients with chronic rhinosinusitis.Methods: A total of 100 patients with chronic rhinosinusitis were randomly divided into the observation group and control group(50 cases each group).The observation group and control group were treated with low temperate radiofrequency ablation and electrical microdebrider,respectively.The intraoperative situation,nasal ventilation function and Kennedy score between two groups were compared.Results: The intraoperative hemorrhage volume and operative duration in observation group were significantly less than those in control group(P<0.01).The rhinorrhea after 1 week of treatment and scar scores after 1 week and month of treatment in observation group were significantly better than those in control group(P<0.01).The differences of the nasal polyps,edema,and crusting scores in postoperative different time-points between two groups were not statistically significant(P>0.05).The acoustic rhinometry and nasal resistance in observation group were significantly better than those in control group(P<0.01).Conclusions: The treatment of chronic rhinosinusitis with the low temperature radiofrequency ablation during nasal endoscopy is effective,which can reduce the operative difficulty,improve nasal ventilation function,and is worthy of clinical application.
Objective: To investigate the clinical effects of the low temperature radiofrequency ablation during nasal endoscopy in the improvement of nasal ventilation function of patients with chronic rhinosinusitis.Methods: A total of 100 patients with chronic rhinosinusitis were randomly divided into the observation group and control group(50 cases each group).The observation group and control group were treated with low temperate radiofrequency ablation and electrical microdebrider,respectively.The intraoperative situation,nasal ventilation function and Kennedy score between two groups were compared.Results: The intraoperative hemorrhage volume and operative duration in observation group were significantly less than those in control group(P<0.01).The rhinorrhea after 1 week of treatment and scar scores after 1 week and month of treatment in observation group were significantly better than those in control group(P<0.01).The differences of the nasal polyps,edema,and crusting scores in postoperative different time-points between two groups were not statistically significant(P>0.05).The acoustic rhinometry and nasal resistance in observation group were significantly better than those in control group(P<0.01).Conclusions: The treatment of chronic rhinosinusitis with the low temperature radiofrequency ablation during nasal endoscopy is effective,which can reduce the operative difficulty,improve nasal ventilation function,and is worthy of clinical application.
2016, 41(7): 896-899.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.019
Abstract:
Objective: To investigate the relationship between the influence factors of resilience and quality of life in burn patients for providing the theory basis in preventing the psychological crisis,improving compliance,selecting psychological intervention measures and enhancing the quality of life.Methods: The general data,resilience and quality of life in 110 burn patients during the rehabilitation period were investigated,the influencing factors of resilience were analyzed.Results: The strength,optimistic scores and total scores of resilience in severe and moderate burn patients were higher than those in mild burn patients.Among the different demographic characteristics,the gender,occupation and marriage were the major factors in affecting resilience,and the positive coping style and social support were also the important factors.The resilience was positive correlation with the quality of life in burn patients.Conclusions: The different nursing intervention measures are formulated according to the influencing factors of resilience in burn patients,which can improve the resilience and quality of life.
Objective: To investigate the relationship between the influence factors of resilience and quality of life in burn patients for providing the theory basis in preventing the psychological crisis,improving compliance,selecting psychological intervention measures and enhancing the quality of life.Methods: The general data,resilience and quality of life in 110 burn patients during the rehabilitation period were investigated,the influencing factors of resilience were analyzed.Results: The strength,optimistic scores and total scores of resilience in severe and moderate burn patients were higher than those in mild burn patients.Among the different demographic characteristics,the gender,occupation and marriage were the major factors in affecting resilience,and the positive coping style and social support were also the important factors.The resilience was positive correlation with the quality of life in burn patients.Conclusions: The different nursing intervention measures are formulated according to the influencing factors of resilience in burn patients,which can improve the resilience and quality of life.
2016, 41(7): 900-902,905.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.020
Abstract:
Objective: To explore the relationship between the plasma homocysteine(Hcy) level and acute cerebral infarction,and its correlation with plasma folic acid and vitamin B12.Methods: One hundred and twenty patients with acute cerebral infarction diagnosed by head CT or MRI and 98 healthy people were divided into the acute cerebral infarction group and control group,respectively.The levels of plasma homocysteine,and plasma folic acid and vitamin B12 in two groups were measured by fluorescence polarization immunoassay(FPLA) and electrochemical luminescence immunoassay(ECLI),respectively.Results: The levels of plasma homocysteine,plasma folic acid and vitamin B12 in acute cerebral infarction group were significantly higher than those in control group(P<0.01).The folic acid and vitamin B12 levels of acute cerebral infarction group were significantly lower than those in confrol group(P<0.01).The level of plasma homocysteine was negative correlation with the levels of plasma folic acid and vitamin B12 in acute cerebral infarction group(P<0.05).Conclusions: The hyperhomocysteinemia is an independent risk factor of acute cerebral infarction.Supplementing the folic acid and vitamin B12 can reduce the serum homocysteine,which can reduce the incidence of cerebral infarction.
Objective: To explore the relationship between the plasma homocysteine(Hcy) level and acute cerebral infarction,and its correlation with plasma folic acid and vitamin B12.Methods: One hundred and twenty patients with acute cerebral infarction diagnosed by head CT or MRI and 98 healthy people were divided into the acute cerebral infarction group and control group,respectively.The levels of plasma homocysteine,and plasma folic acid and vitamin B12 in two groups were measured by fluorescence polarization immunoassay(FPLA) and electrochemical luminescence immunoassay(ECLI),respectively.Results: The levels of plasma homocysteine,plasma folic acid and vitamin B12 in acute cerebral infarction group were significantly higher than those in control group(P<0.01).The folic acid and vitamin B12 levels of acute cerebral infarction group were significantly lower than those in confrol group(P<0.01).The level of plasma homocysteine was negative correlation with the levels of plasma folic acid and vitamin B12 in acute cerebral infarction group(P<0.05).Conclusions: The hyperhomocysteinemia is an independent risk factor of acute cerebral infarction.Supplementing the folic acid and vitamin B12 can reduce the serum homocysteine,which can reduce the incidence of cerebral infarction.
2016, 41(7): 903-905.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.021
Abstract:
Objective: To observe the clinical effects of vacuum sealing drainage(VSD) combined with oxygen loaded fluid irrigation in the treatment of chronic wounds.Methods: Sixty-eight chronic wounds patients treated with debridement were randomly divided into the observation group and control group(34 cases each group).The observation group were treated with VSD combined with oxygen loaded fluid irrigation,and the control group were treated with VSD combined with normal saline irrigation.After 7 days of treatment,the tissue fluid oxygen partial pressure of all patients was measured,and the closed negative pressure drainage device was dismantled.After assessing the wound and whole body condition,the patients were treated with phase Ⅱ operation.After 7 days,the bacterial clearance rate,wound granulation tissue coverage,foam dry rate,incidence of drainage blockage,phase Ⅱ operation methods and survival rate of skin graft or skin flap transplantation in two groups were calculated and recorded.Results: The difference of the drainage tube blockage rate between two groups was not statistically significant(P>0.05).The foam dry rate,granulation tissue coverage rate and bacterial clearance rate in observation group were higher than those in control group(P<0.05 to P<0.01).After 7 days of treatment,the local wound tissue oxygen partial pressure in observation group[(12.80±4.01) mmHg] was significantly higher than that in control group[(41.32±4.03) mmHg](P<0.01).The skin graft and skin flap transplantation were used in two groups,the difference of which was not statistically significant(P>0.05).The survival rates of skin graft and skin flap transplantation in observation group were significant higher than those in control group(P<0.01).All patients were followed up for 1 to 3 months.The healing of all skin or skin flap were good,the function and appearance of which was satisfied,and no recurrence was found.Conclusions: The effects of the stage Ⅱ surgery,VSD drainage combined with oxygen loaded fluid irrigating after debriding in the treatment of chronic wounds are good,which is worthy of clinical promotion.
Objective: To observe the clinical effects of vacuum sealing drainage(VSD) combined with oxygen loaded fluid irrigation in the treatment of chronic wounds.Methods: Sixty-eight chronic wounds patients treated with debridement were randomly divided into the observation group and control group(34 cases each group).The observation group were treated with VSD combined with oxygen loaded fluid irrigation,and the control group were treated with VSD combined with normal saline irrigation.After 7 days of treatment,the tissue fluid oxygen partial pressure of all patients was measured,and the closed negative pressure drainage device was dismantled.After assessing the wound and whole body condition,the patients were treated with phase Ⅱ operation.After 7 days,the bacterial clearance rate,wound granulation tissue coverage,foam dry rate,incidence of drainage blockage,phase Ⅱ operation methods and survival rate of skin graft or skin flap transplantation in two groups were calculated and recorded.Results: The difference of the drainage tube blockage rate between two groups was not statistically significant(P>0.05).The foam dry rate,granulation tissue coverage rate and bacterial clearance rate in observation group were higher than those in control group(P<0.05 to P<0.01).After 7 days of treatment,the local wound tissue oxygen partial pressure in observation group[(12.80±4.01) mmHg] was significantly higher than that in control group[(41.32±4.03) mmHg](P<0.01).The skin graft and skin flap transplantation were used in two groups,the difference of which was not statistically significant(P>0.05).The survival rates of skin graft and skin flap transplantation in observation group were significant higher than those in control group(P<0.01).All patients were followed up for 1 to 3 months.The healing of all skin or skin flap were good,the function and appearance of which was satisfied,and no recurrence was found.Conclusions: The effects of the stage Ⅱ surgery,VSD drainage combined with oxygen loaded fluid irrigating after debriding in the treatment of chronic wounds are good,which is worthy of clinical promotion.
2016, 41(7): 906-907,911.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.022
Abstract:
Objective: To investigate the clinical predictive effect of the ervicovaginal secretion fetal fibronectin(FFN) in term pregnancy.Methods: Two hundred and forty-seven pregnant women with 37 to 41+6 pregnancy weeks were divided into the positive and negative FFN group.The delivery methods between two groups were compared.The puerperas with vaginal delivery were selected,the delivery time of which was analyzed for evaluating the value of FFN in intrapartum.Results: The vaginal delivery and cesarean section rates in the pregnant women with the positive expression of cervicovaginal secretion FFN were 70.83% and 29.17%,respectively,while the vaginal delivery and cesarean section rates in the pregnant women with the negative expression of cervicovaginal secretion FFN were 57.48% and 42.52%,respectively,the difference between two groups was statistically significant(P<0.05).The vaginal delivery time in pregnant women with positive FFN was significantly less than that in pregnant women with negative FFN(P<0.01).The 7 d-delivery rates in pregnant women with positive FFN and negative FFN were 90.59% and 67.12%,respectively,the difference of which was statistically significant(P<0.01).Conclusions: The detection of cervicovaginal secretion FFN in term pregnancy has clinical significance.
Objective: To investigate the clinical predictive effect of the ervicovaginal secretion fetal fibronectin(FFN) in term pregnancy.Methods: Two hundred and forty-seven pregnant women with 37 to 41+6 pregnancy weeks were divided into the positive and negative FFN group.The delivery methods between two groups were compared.The puerperas with vaginal delivery were selected,the delivery time of which was analyzed for evaluating the value of FFN in intrapartum.Results: The vaginal delivery and cesarean section rates in the pregnant women with the positive expression of cervicovaginal secretion FFN were 70.83% and 29.17%,respectively,while the vaginal delivery and cesarean section rates in the pregnant women with the negative expression of cervicovaginal secretion FFN were 57.48% and 42.52%,respectively,the difference between two groups was statistically significant(P<0.05).The vaginal delivery time in pregnant women with positive FFN was significantly less than that in pregnant women with negative FFN(P<0.01).The 7 d-delivery rates in pregnant women with positive FFN and negative FFN were 90.59% and 67.12%,respectively,the difference of which was statistically significant(P<0.01).Conclusions: The detection of cervicovaginal secretion FFN in term pregnancy has clinical significance.
2016, 41(7): 908-911.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.023
Abstract:
Objective: To compare the therapeutic effects of small incision nucleus fragmentation method and phacoemulsification cataract surgery in the treatment of senile hard nuclear cataract.Methods: Seventy patients(78 eyes) with senile hard nuclear cataract were randomly divided into the observation group and control group[35 cases(39 eyes),each group].The observation group and control group were treated with the small incision nucleus fragmentation method and phacoemulsification cataract surgery,respectively.The visual acuity,astigmatism degree,adverse reaction and quality of life between two groups were compared.Results: The difference of the visual acuity between two groups before operation was not statistically significant(P> 0.05),the postoperative visual acuity levels in two groups were significantly improved(P<0.01),and the visual acuity levels after 4 and 8 weeks of operation in observation group were higher than those in control group(P<0.01 and P<0.05).The difference of astigmatism degree between two groups before operation was not statistically significant(P>0.05),the astigmatism degree increased significantly after 1 week of operation,and decreased after 8 weeks of operation(P<0.01 and P<0.05).The difference of astigmatism degree between two groups after operation was not statistically significant(P>0.05).The incidence of adverse reaction in observation group(25.64%) was lower than that in control group(48.72%) (P<0.05).The difference of the postoperative quality of life scores between two groups was not statistically significant(P>0.05).Conclusions: According to the visual acuity level,astigmatism degree,quality of life and complications,the small incision cataract extraction and chop technique can be used as the treatment method of senile cataract in the primary hospital.
Objective: To compare the therapeutic effects of small incision nucleus fragmentation method and phacoemulsification cataract surgery in the treatment of senile hard nuclear cataract.Methods: Seventy patients(78 eyes) with senile hard nuclear cataract were randomly divided into the observation group and control group[35 cases(39 eyes),each group].The observation group and control group were treated with the small incision nucleus fragmentation method and phacoemulsification cataract surgery,respectively.The visual acuity,astigmatism degree,adverse reaction and quality of life between two groups were compared.Results: The difference of the visual acuity between two groups before operation was not statistically significant(P> 0.05),the postoperative visual acuity levels in two groups were significantly improved(P<0.01),and the visual acuity levels after 4 and 8 weeks of operation in observation group were higher than those in control group(P<0.01 and P<0.05).The difference of astigmatism degree between two groups before operation was not statistically significant(P>0.05),the astigmatism degree increased significantly after 1 week of operation,and decreased after 8 weeks of operation(P<0.01 and P<0.05).The difference of astigmatism degree between two groups after operation was not statistically significant(P>0.05).The incidence of adverse reaction in observation group(25.64%) was lower than that in control group(48.72%) (P<0.05).The difference of the postoperative quality of life scores between two groups was not statistically significant(P>0.05).Conclusions: According to the visual acuity level,astigmatism degree,quality of life and complications,the small incision cataract extraction and chop technique can be used as the treatment method of senile cataract in the primary hospital.
2016, 41(7): 912-914.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.024
Abstract:
Objective: To investigate the effects of different concentrations of ropivacaine on single lung ventilation in thoracic epidural anesthesia.Methods: One hundred and twenty patients with esophageal cancer were randomly divided into the control group,which were treated with simple intravenous anesthesia,and group A,B and C,whose were treated with intravenous anesthesia combined with 0.5%,0.25% and 0.125% of ropivacaine epidural block,respectively(30 cases each group).The mixed venous blood in all patients were analyzed before single lung ventilation and after 15 and 30 min of single lung ventilation.Results: The operation time in group B was shorter than that in group C and control group(P<0.05),the differences of single lung ventilation time between 4 groups were not statistically significant(P>0.05).The fentanyl dosage in A,B and C groups were less than that in control group(P<0.05).The dosage of propofol in group B was less than that in control group(P<0.05),but the differences of which between group A,B and control group were not statistically significant(P>0.05).The SBP and DBP in group A and B were lower than those in control group after 15 and 30 min of single lung ventilation(P<0.05 to P<0.01),the SBP in group C was lower than that in control group after 15 min of lung ventilation(P<0.05),and the DBP in group C was higher than that in group A and B(P<0.05).Conclusions: The different concentrations of ropivacaine in epidural block has different effects on the single lung ventilation,the 0.125% ropivacaine in thoracic epidural anesthesia is safe.
Objective: To investigate the effects of different concentrations of ropivacaine on single lung ventilation in thoracic epidural anesthesia.Methods: One hundred and twenty patients with esophageal cancer were randomly divided into the control group,which were treated with simple intravenous anesthesia,and group A,B and C,whose were treated with intravenous anesthesia combined with 0.5%,0.25% and 0.125% of ropivacaine epidural block,respectively(30 cases each group).The mixed venous blood in all patients were analyzed before single lung ventilation and after 15 and 30 min of single lung ventilation.Results: The operation time in group B was shorter than that in group C and control group(P<0.05),the differences of single lung ventilation time between 4 groups were not statistically significant(P>0.05).The fentanyl dosage in A,B and C groups were less than that in control group(P<0.05).The dosage of propofol in group B was less than that in control group(P<0.05),but the differences of which between group A,B and control group were not statistically significant(P>0.05).The SBP and DBP in group A and B were lower than those in control group after 15 and 30 min of single lung ventilation(P<0.05 to P<0.01),the SBP in group C was lower than that in control group after 15 min of lung ventilation(P<0.05),and the DBP in group C was higher than that in group A and B(P<0.05).Conclusions: The different concentrations of ropivacaine in epidural block has different effects on the single lung ventilation,the 0.125% ropivacaine in thoracic epidural anesthesia is safe.
2016, 41(7): 914-916.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.025
Abstract:
Objective: To sum the clinical experience of galactic fistula during suckling period after augmentation mammaplasty with polyacrylamide hydrogel injection.Methods: The clinical characteristics in 7 galactic fistula cases with injection augmentation mammoplasty were analyzed.The breast was sectioned at inframammary fold and rinsed,then the implant was cleared using special curette.The galactopoiesis was inhibited by the comprehensive therapy of negative pressure drainage of pressure gradual decreasing,drug combined with food after operation.Results: The surgical incisions in 7 patients healed after 12 to 20 days of operation.The injection residues were not found by the breast ultrasound examination after 1 to 8 months of operation,and the obvious reduction in 7 disease breasts were found after operation.Conclusions: The incision and drainage in time,removing implants and preventing galactopoiesis are the key of treatment.The breast feeding in female with augmentation mammaplasty history should be avoided after delivery.
Objective: To sum the clinical experience of galactic fistula during suckling period after augmentation mammaplasty with polyacrylamide hydrogel injection.Methods: The clinical characteristics in 7 galactic fistula cases with injection augmentation mammoplasty were analyzed.The breast was sectioned at inframammary fold and rinsed,then the implant was cleared using special curette.The galactopoiesis was inhibited by the comprehensive therapy of negative pressure drainage of pressure gradual decreasing,drug combined with food after operation.Results: The surgical incisions in 7 patients healed after 12 to 20 days of operation.The injection residues were not found by the breast ultrasound examination after 1 to 8 months of operation,and the obvious reduction in 7 disease breasts were found after operation.Conclusions: The incision and drainage in time,removing implants and preventing galactopoiesis are the key of treatment.The breast feeding in female with augmentation mammaplasty history should be avoided after delivery.
2016, 41(7): 917-919.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.026
Abstract:
Objective: To investigate the effects of harmonic scalpel combined with high-frequency bipolar coagulation on the recurrent laryngeal nerve paralysis and parathyroid injury in patients with thyroid carcinoma.Methods: Ninety-four patients with thyroid carcinoma were divided into the observation group and control group according to the random number table(47 cases each group).The observation group and control group were treated with harmonic scalpel combined with high-frequency bipolar coagulation and traditional operation,respectively.The surgery indicators,serology,and the recurrent laryngeal nerve paralysis and parathyroid injury between two groups were compared.Results: The intraoperative bleeding volume,operation time,incision size,drainage volume and hospitalization time in observation group were significantly less than those in control group(P<0.01).After operation,the level of blood phosphorus and incidence of hypothyroidism in observation group were significantly lower than those in control group(P<0.01 and P<0.05),and the levels of serum calcium and parathyroid in observation group were significantly higher than those in control group(P<0.01).Conclusions: Harmonic scalpel combined with high-frequency bipolar coagulation can help to optimize the operation indicators,stable serological indexes,and reduce the incidence of the recurrent laryngcal nerve paralysis and parathyroid injury.
Objective: To investigate the effects of harmonic scalpel combined with high-frequency bipolar coagulation on the recurrent laryngeal nerve paralysis and parathyroid injury in patients with thyroid carcinoma.Methods: Ninety-four patients with thyroid carcinoma were divided into the observation group and control group according to the random number table(47 cases each group).The observation group and control group were treated with harmonic scalpel combined with high-frequency bipolar coagulation and traditional operation,respectively.The surgery indicators,serology,and the recurrent laryngeal nerve paralysis and parathyroid injury between two groups were compared.Results: The intraoperative bleeding volume,operation time,incision size,drainage volume and hospitalization time in observation group were significantly less than those in control group(P<0.01).After operation,the level of blood phosphorus and incidence of hypothyroidism in observation group were significantly lower than those in control group(P<0.01 and P<0.05),and the levels of serum calcium and parathyroid in observation group were significantly higher than those in control group(P<0.01).Conclusions: Harmonic scalpel combined with high-frequency bipolar coagulation can help to optimize the operation indicators,stable serological indexes,and reduce the incidence of the recurrent laryngcal nerve paralysis and parathyroid injury.
2016, 41(7): 920-922.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.027
Abstract:
Objective: To investigate the clinical application effects of the super glass-fiber splint in periodontal regeneration surgery.Methods: Twenty-seven patients with chronic periodontitis of anterior teeth,the periodontal pocket depth of which was more than or equal to 5 mm complicated with vertical bone resorption after basic treatment,were randomly divided into group A(13 cases)and group B(14 cases).The group A were treated with bone graft combined with guided tissue regeneration(GTR),the group B were treated with bone graft combined with GTR after super glass-fiber splint fixation.The clinical attachment loss(CAL) and result of X-ray in all disease teeth were recorded before operation and after 6 and 12 months of operation.Results: Compared with that in two groups before operation,the CAL of the disease teeth decreased significantly after 6 and 12 months of operation(P<0.01),the CAL of the disease teeth decreased significantly after 6 and 12 months of operation(P<0.01),the CAL of the disease teeth in group B was significantly higher than that in A group( P<0.01).The differences of the results of X-ray between two groups were not statistically significant after 6 and 12 months of operation(P>0.05).Conclusions: The super glass-fiber splint fixation before periodontal regeneration surgery can effectively promote the regeneration of periodontal tissue and consolidate the treatment effect of periodontal disease.
Objective: To investigate the clinical application effects of the super glass-fiber splint in periodontal regeneration surgery.Methods: Twenty-seven patients with chronic periodontitis of anterior teeth,the periodontal pocket depth of which was more than or equal to 5 mm complicated with vertical bone resorption after basic treatment,were randomly divided into group A(13 cases)and group B(14 cases).The group A were treated with bone graft combined with guided tissue regeneration(GTR),the group B were treated with bone graft combined with GTR after super glass-fiber splint fixation.The clinical attachment loss(CAL) and result of X-ray in all disease teeth were recorded before operation and after 6 and 12 months of operation.Results: Compared with that in two groups before operation,the CAL of the disease teeth decreased significantly after 6 and 12 months of operation(P<0.01),the CAL of the disease teeth decreased significantly after 6 and 12 months of operation(P<0.01),the CAL of the disease teeth in group B was significantly higher than that in A group( P<0.01).The differences of the results of X-ray between two groups were not statistically significant after 6 and 12 months of operation(P>0.05).Conclusions: The super glass-fiber splint fixation before periodontal regeneration surgery can effectively promote the regeneration of periodontal tissue and consolidate the treatment effect of periodontal disease.
2016, 41(7): 945-947.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.038
Abstract:
Objective: To investigate the correlations between red blood cell distribution width(RDW),neutrophil/lymphocyte ratio(NLR),and clinical index of osteoarthritis(OA).Methods: Forty-two OA patients and 44 healthy people were divided into the OA group and control group.The correlations between the levels of RDW and NLR,and disease activity index in OA patients were analyzed.Results: The levels of RDW and NLR in OA group were significantly higher than those in control group(P<0.01).The scores of RDW and NLR in OA group were positively correlated with the scores of erythrocyte sedimentation rate and visual analogue scale(P<0.01).Conclusions: The RDW and NLR maybe a good index in estimating the disease activity of OA.
Objective: To investigate the correlations between red blood cell distribution width(RDW),neutrophil/lymphocyte ratio(NLR),and clinical index of osteoarthritis(OA).Methods: Forty-two OA patients and 44 healthy people were divided into the OA group and control group.The correlations between the levels of RDW and NLR,and disease activity index in OA patients were analyzed.Results: The levels of RDW and NLR in OA group were significantly higher than those in control group(P<0.01).The scores of RDW and NLR in OA group were positively correlated with the scores of erythrocyte sedimentation rate and visual analogue scale(P<0.01).Conclusions: The RDW and NLR maybe a good index in estimating the disease activity of OA.
2016, 41(7): 948-949.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.039
Abstract:
Objective: To investigate the level of uric acid and prevalence of hyperuricemia in examination population from Nanshan Hospital of Shenzhen,and analyze the relative factors of hyperuricemia.Methods: The prevalence of hyperuricemia in 2 900 physical examination people in 2014 were calculated,and the related influencing factors were analyzed by Logistic regression model.Results: The blood uric acid level in man[(354.6±83.8) mol/L] was significantly higher than that in woman[(267.3±61.1) mol/L](P<0.01).The hyperuricemia prevalence rate in man(19.3%) was significantly higher than that in women(11.4%)(P<0.01).The logistic regression analysis showed that the age,male,obesity,hypertension and high triglycerides were the risk factors of hyperuricemia(P<0.05).Conclusions: The serum uric acid level is high in the physical examination population from Nanshan Hospital of Shenzhen,and the age,male,obesity,high blood pressure and high triglyceride are the risk factors of hyperuricemia.
Objective: To investigate the level of uric acid and prevalence of hyperuricemia in examination population from Nanshan Hospital of Shenzhen,and analyze the relative factors of hyperuricemia.Methods: The prevalence of hyperuricemia in 2 900 physical examination people in 2014 were calculated,and the related influencing factors were analyzed by Logistic regression model.Results: The blood uric acid level in man[(354.6±83.8) mol/L] was significantly higher than that in woman[(267.3±61.1) mol/L](P<0.01).The hyperuricemia prevalence rate in man(19.3%) was significantly higher than that in women(11.4%)(P<0.01).The logistic regression analysis showed that the age,male,obesity,hypertension and high triglycerides were the risk factors of hyperuricemia(P<0.05).Conclusions: The serum uric acid level is high in the physical examination population from Nanshan Hospital of Shenzhen,and the age,male,obesity,high blood pressure and high triglyceride are the risk factors of hyperuricemia.
2016, 41(7): 950-953.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.040
Abstract:
Objective: To explore the application effects of self-management in clinical blood transfusion major students.Methods: Two classes were randomly selected from the clinical blood transfusion major in Bengbu Medical College,and divided into the experiment group and control group(30 cases each group).The control group were managed using the traditional education and management mode,and the experiment group were managed using self-management mode.After four semesters of intervention,the organizational discipline,ideological status and academic performance between two groups were compared.Results: After intervention,the differences of the arriving late time and truancycount in the first and second semester between two groups were not statistically significant(P>0.05),the arriving late time in the third and fourth semester in experiment group was significantly less than that in control group(P<0.01).The difference of other disciplinary action in the first three semesters between two groups was not statistically significant(P>0.05),which in the fourth semester in experiment group was lower than that in control group(P<0.05).The number of people of joining the party and participating in community in experiment group were significantly more than that in control group(P<0.01).From the second semester to the fourth semester,the compulsory course examination scores in experiment group were significantly higher than that in control group(P<0.01).At the fourth semester,the students of passing the national College English Test band four and winning award in experiment group were significantly more than that in control group(P<0.01).Conclusions: The implementation of the self-management in clinical blood transfusion major students can effectively improve their autonomy,self-control,ideas and academic performance,and which can provide the security for the special occupation of blood transfusion,and is worth of promoting in the ideological and political education of college students.
Objective: To explore the application effects of self-management in clinical blood transfusion major students.Methods: Two classes were randomly selected from the clinical blood transfusion major in Bengbu Medical College,and divided into the experiment group and control group(30 cases each group).The control group were managed using the traditional education and management mode,and the experiment group were managed using self-management mode.After four semesters of intervention,the organizational discipline,ideological status and academic performance between two groups were compared.Results: After intervention,the differences of the arriving late time and truancycount in the first and second semester between two groups were not statistically significant(P>0.05),the arriving late time in the third and fourth semester in experiment group was significantly less than that in control group(P<0.01).The difference of other disciplinary action in the first three semesters between two groups was not statistically significant(P>0.05),which in the fourth semester in experiment group was lower than that in control group(P<0.05).The number of people of joining the party and participating in community in experiment group were significantly more than that in control group(P<0.01).From the second semester to the fourth semester,the compulsory course examination scores in experiment group were significantly higher than that in control group(P<0.01).At the fourth semester,the students of passing the national College English Test band four and winning award in experiment group were significantly more than that in control group(P<0.01).Conclusions: The implementation of the self-management in clinical blood transfusion major students can effectively improve their autonomy,self-control,ideas and academic performance,and which can provide the security for the special occupation of blood transfusion,and is worth of promoting in the ideological and political education of college students.
2016, 41(7): 954-955,958.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.041
Abstract:
Objective: To explore the application of medical professionalism training mode reform effects.Methods: By demonstrating formed in accordance with the medical education reform and development direction and the social demand for talents of medical professionalism training mode,training mode reform of the class of 2014 112 students and culture after the implementation of the reform mode of graduates of 2015 113 students as the research object,of its graduate theoretical examination and skills examination data analysis.Results: Medical professionalism cultivation mode after the implementation of the students graduated from the theory test scores,graduation skills assessment scores and total score were higher than those of the students prior to the implementation of the model,the difference was statistically significant(P<0.05).Conclusions: Application of medical professionalism training mode and conforms to the trend of the reform of medical education,promote the learning of students' theoretical knowledge and clinical skills training,promote the spirit of medical students' comprehensive quality raise.
Objective: To explore the application of medical professionalism training mode reform effects.Methods: By demonstrating formed in accordance with the medical education reform and development direction and the social demand for talents of medical professionalism training mode,training mode reform of the class of 2014 112 students and culture after the implementation of the reform mode of graduates of 2015 113 students as the research object,of its graduate theoretical examination and skills examination data analysis.Results: Medical professionalism cultivation mode after the implementation of the students graduated from the theory test scores,graduation skills assessment scores and total score were higher than those of the students prior to the implementation of the model,the difference was statistically significant(P<0.05).Conclusions: Application of medical professionalism training mode and conforms to the trend of the reform of medical education,promote the learning of students' theoretical knowledge and clinical skills training,promote the spirit of medical students' comprehensive quality raise.
2016, 41(7): 956-958.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.042
Abstract:
Objective: To investigate the postoperative psychological problems in adult treated with circumcision,and formulate the nursing intervention.Methods: Four hundred and thirty-two adult patients treated with circumcision were randomly divided into the control group(208 cases) and observation group(216 cases).The influencing factors of the postoperative psychological status were investigated,the corresponding nursing intervention measure was formulated.The depression and anxiety between two groups were compared before and after treatment.Results: The postoperative psychological status in patients treated with circumcision were affected by many factors,and the main influencing factors included worrying about surgery success(96.6%),postoperative complications(89.9%),marriage(88.0%),recurrence(82.2%) and postoperative pain(73.1%).Compared with that before intervention,the anxiety and depression symptoms in two groups reduced significantly after implementating nursing intervention(P<0.01).The scores of the anxiety and depression symptoms in observation group were significantly lower than those in control group after nursing intervention(P<0.01).Conclusions: The postoperative anxiety and depression symptoms are usually found in adult treated with circumcision.Implementating nursing intervention can effectively improve the psychological condition and promote recovery of patients.
Objective: To investigate the postoperative psychological problems in adult treated with circumcision,and formulate the nursing intervention.Methods: Four hundred and thirty-two adult patients treated with circumcision were randomly divided into the control group(208 cases) and observation group(216 cases).The influencing factors of the postoperative psychological status were investigated,the corresponding nursing intervention measure was formulated.The depression and anxiety between two groups were compared before and after treatment.Results: The postoperative psychological status in patients treated with circumcision were affected by many factors,and the main influencing factors included worrying about surgery success(96.6%),postoperative complications(89.9%),marriage(88.0%),recurrence(82.2%) and postoperative pain(73.1%).Compared with that before intervention,the anxiety and depression symptoms in two groups reduced significantly after implementating nursing intervention(P<0.01).The scores of the anxiety and depression symptoms in observation group were significantly lower than those in control group after nursing intervention(P<0.01).Conclusions: The postoperative anxiety and depression symptoms are usually found in adult treated with circumcision.Implementating nursing intervention can effectively improve the psychological condition and promote recovery of patients.
2016, 41(7): 959-962.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.043
Abstract:
Objective: To investigate the application effects of POSSUM scoring in the precision nursing intervention for postoperative complications of pancreatoduodenectomy.Methods: Eight hundred and twenty-four patients treated with pancreatoduodenectomy were randomly divided into the observation group and control group,412 cases each group.Two groups were nursed with routine care.The risks of postoperative complication in the observation group were predicted with the POSSUM scoring system,and the high risk patients were treated with the targeted intervention.Results: The incidence of postoperative complication in observation group was lower than that in control group(P<0.01),and the difference of the incidence of predicting complication between two groups was not statistically significant(P>0.05).The incidence of actual complication was lower than that of predicting complication using POSSUM scoring in observation group(P<0.01).The difference of the incidence between predicting and actual complication was not statistical significance(P>0.05).Conclusions: The application of POSSUM scoring in predicting the risk of pancreatoduodenectomy is accurate and valuable,which can decrease the postoperative complication of pancreatoduodenectomy,and improve the prognosis.
Objective: To investigate the application effects of POSSUM scoring in the precision nursing intervention for postoperative complications of pancreatoduodenectomy.Methods: Eight hundred and twenty-four patients treated with pancreatoduodenectomy were randomly divided into the observation group and control group,412 cases each group.Two groups were nursed with routine care.The risks of postoperative complication in the observation group were predicted with the POSSUM scoring system,and the high risk patients were treated with the targeted intervention.Results: The incidence of postoperative complication in observation group was lower than that in control group(P<0.01),and the difference of the incidence of predicting complication between two groups was not statistically significant(P>0.05).The incidence of actual complication was lower than that of predicting complication using POSSUM scoring in observation group(P<0.01).The difference of the incidence between predicting and actual complication was not statistical significance(P>0.05).Conclusions: The application of POSSUM scoring in predicting the risk of pancreatoduodenectomy is accurate and valuable,which can decrease the postoperative complication of pancreatoduodenectomy,and improve the prognosis.
2016, 41(7): 962-964.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.044
Abstract:
Objective: To investigate the effects of Doula pain-abating machine on the analgesia in vaginal delivery.Methods: Two hundred and forty full term pregnant women scheduled by vaginal delivery were randomly divided into the Doula pain-abating machine group and control group(120 cases each group).The Doula pain-abating machine group and control group were treated with GT-4A machine and conventional doula care during vaginal delivery,respectively.The pain-abating effects,labor time of the first stage,second stage and third stage,rates of vaginal delivery and cesarean section and bleeding after 2 hours of birth between two groups were compared.Results: The analgesia effects in Doula pain-abating machine group were significantly better than that in control group(P<0.01).The labor time of the first stage and second stage in Doula pain-abating machine group were significantly shorter than those in control group(P<0.01).The rate of cesarean section in Doula pain-abating machine group(7,5%) were less than that in control group(16.7%)(P<0.01).The differences of the bleeding amount after 2 hours of birth and labor time of the third stage between two groups were not statistically significant(P>0.05).Conclusions: The application of Doula pain-abating machine in labor analgesia can play good analgesia effects,relieve the pain of patients,accelerate the delivery process and decrease the rate of cesarean section,which is worthy of promotion in clinic.
Objective: To investigate the effects of Doula pain-abating machine on the analgesia in vaginal delivery.Methods: Two hundred and forty full term pregnant women scheduled by vaginal delivery were randomly divided into the Doula pain-abating machine group and control group(120 cases each group).The Doula pain-abating machine group and control group were treated with GT-4A machine and conventional doula care during vaginal delivery,respectively.The pain-abating effects,labor time of the first stage,second stage and third stage,rates of vaginal delivery and cesarean section and bleeding after 2 hours of birth between two groups were compared.Results: The analgesia effects in Doula pain-abating machine group were significantly better than that in control group(P<0.01).The labor time of the first stage and second stage in Doula pain-abating machine group were significantly shorter than those in control group(P<0.01).The rate of cesarean section in Doula pain-abating machine group(7,5%) were less than that in control group(16.7%)(P<0.01).The differences of the bleeding amount after 2 hours of birth and labor time of the third stage between two groups were not statistically significant(P>0.05).Conclusions: The application of Doula pain-abating machine in labor analgesia can play good analgesia effects,relieve the pain of patients,accelerate the delivery process and decrease the rate of cesarean section,which is worthy of promotion in clinic.
2016, 41(7): 965-968.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.045
Abstract:
Objective: To investigate the application effects of fast track surgery(FTS) in nursing the perioperative patients treated with the modified radical mastectomy.Methods: Thirty-five patients in 2014 and 35 patients in 2015 were divided into the control group and observation group,respectively.The control group were nursed with routine care,and the observation group were additionally nursed with FTS based on the control group.The incidence of postoperative complications and recovery of the arm function between two groups were compared.Results: The differences of the incidences of the subcutaneous hydrops,flap necrosis and upper limb edema between two groups were not statistical significant(P>0.05).The function recovery of the injury limb in observation group was significantly better than that in control group(P<0.01).The hospitalization time in observation group was significantly shorter than that in control group(P<0.01).Conclusions: The FTS concept can improve the recovery of arm function in patients treated with the modified radical mastectomy,and do not increase the incidence of complication.
Objective: To investigate the application effects of fast track surgery(FTS) in nursing the perioperative patients treated with the modified radical mastectomy.Methods: Thirty-five patients in 2014 and 35 patients in 2015 were divided into the control group and observation group,respectively.The control group were nursed with routine care,and the observation group were additionally nursed with FTS based on the control group.The incidence of postoperative complications and recovery of the arm function between two groups were compared.Results: The differences of the incidences of the subcutaneous hydrops,flap necrosis and upper limb edema between two groups were not statistical significant(P>0.05).The function recovery of the injury limb in observation group was significantly better than that in control group(P<0.01).The hospitalization time in observation group was significantly shorter than that in control group(P<0.01).Conclusions: The FTS concept can improve the recovery of arm function in patients treated with the modified radical mastectomy,and do not increase the incidence of complication.
2016, 41(7): 968-970.
doi: 10.13898/j.cnki.issn.1000-2200.2016.07.046
Abstract:
Objective: To explore the clinical effects of comprehensive nursing on patients with diabetes complicated with pulmonary tuberculosis,and nursing measures.Methods: Eighty-seven diabetic patients complicated with pulmonary tuberculosis were randomly divided into the observation group(45 cases) and control group(42 cases).The control group were nursed using routine method,and the observation group were nursed using comprehensive nursing based on routine method.The levels of fasting plasma glucose(FPG),2h postprandial blood glucose(2hPG) and glycated hemoglobin(HbA1c),tuberculosis outcome and adverse reactions between two groups were compared.Results: Compared with before nursing,the levels of FPG,2hPG and HbA1c in two groups significantly decreased after nursing(P<0.01).The decreasing degree of the levels of FPG,2hPG and HbA1c in observation group after nursing were more obvious than that in control group(P<0.01).The cavity closure rate,lesion absorption rate and tubercle bacillus negative conversion rate in observation group were significantly higher than those in control group(P<0.05).The incidences of adverse reactions in observation group and control group were 2.22% and 14.30%,respectively.The differences of the incidences of hypoglycemia,bounce hyperglycemia,infection and malnutrition were statistically significant(P=0.230 to P=1.000).The nursing satisfaction rate in observation group(93.33%) was significantly higher than that in control group(76.2%)(P<0.05).Conclusions: The comprehensive nursing care can effectively stable the blood glucose,which is conducive to sputa turn negative,lesion absorption,reduce adverse reactions,improve treatment compliance and nursing satisfaction,and is worthy of clinical promotion.
Objective: To explore the clinical effects of comprehensive nursing on patients with diabetes complicated with pulmonary tuberculosis,and nursing measures.Methods: Eighty-seven diabetic patients complicated with pulmonary tuberculosis were randomly divided into the observation group(45 cases) and control group(42 cases).The control group were nursed using routine method,and the observation group were nursed using comprehensive nursing based on routine method.The levels of fasting plasma glucose(FPG),2h postprandial blood glucose(2hPG) and glycated hemoglobin(HbA1c),tuberculosis outcome and adverse reactions between two groups were compared.Results: Compared with before nursing,the levels of FPG,2hPG and HbA1c in two groups significantly decreased after nursing(P<0.01).The decreasing degree of the levels of FPG,2hPG and HbA1c in observation group after nursing were more obvious than that in control group(P<0.01).The cavity closure rate,lesion absorption rate and tubercle bacillus negative conversion rate in observation group were significantly higher than those in control group(P<0.05).The incidences of adverse reactions in observation group and control group were 2.22% and 14.30%,respectively.The differences of the incidences of hypoglycemia,bounce hyperglycemia,infection and malnutrition were statistically significant(P=0.230 to P=1.000).The nursing satisfaction rate in observation group(93.33%) was significantly higher than that in control group(76.2%)(P<0.05).Conclusions: The comprehensive nursing care can effectively stable the blood glucose,which is conducive to sputa turn negative,lesion absorption,reduce adverse reactions,improve treatment compliance and nursing satisfaction,and is worthy of clinical promotion.
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