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2017 Vol. 42, No. 3
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2017, 42(3): 281-284.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.001
Abstract:
Objective:To investigate the effects of maternal SEB administration on the TCR Vβ8+T cells in the thymus and peripheral blood of offspring newborn rats.Methods:Pregnant rats with gestational 16 days were injected with 15 μg SEB in 0.2 mL PBS by iv(SEB group),and the control group were treated with the same volume of PBS.The thymus and peripheral blood of newborn offspring rats after 0 to 5 days of delivery were harvested,and the levels of TCR Vβ8+ T cells of whose were analyzed using the flow cytometry.Results:Compared with the control group,the percentage of CD4+ TCR Vβ8+T cells in thymus of offspring newborn rats after 0 to 3 days of delivery significantly decreased in SEB group(P<0.05 to P<0.01),and the difference of which in thymus of offspring newborn rats after 4 to 5 days of delivery between two groups was not statistically significnat(P>0.05).In the thymus of offspring newborn rats after 0 to 5 days of delivery,the percentage of CD8+ TCR Vβ8+ T cells in SEB group was significantly lower than that in control group(P<0.05 to P<0.01),and the absolute number of CD4+Vβ8+ and CD8+Vβ8+ T cells in SEB group significantly decreased compared with the control group(P<0.01).In the peripheral blood of offspring newborn rats after 0 to 5 days of delivery,the percentages of the CD4+ Vβ8+ and CD8+ Vβ8+ T cells,and the absolute number of CD4+ Vβ8+ and CD8+ Vβ8+ T cells in SEB group significantly decreased compared with the control group(P<0.05 to P<0.01).Conclusions:Maternal SEB administration during pregnancy can decrease the levels of TCR Vβ8+T cells in the thymus and peripheral blood of offspring newborn rats,and which can continue into adulthood.
Objective:To investigate the effects of maternal SEB administration on the TCR Vβ8+T cells in the thymus and peripheral blood of offspring newborn rats.Methods:Pregnant rats with gestational 16 days were injected with 15 μg SEB in 0.2 mL PBS by iv(SEB group),and the control group were treated with the same volume of PBS.The thymus and peripheral blood of newborn offspring rats after 0 to 5 days of delivery were harvested,and the levels of TCR Vβ8+ T cells of whose were analyzed using the flow cytometry.Results:Compared with the control group,the percentage of CD4+ TCR Vβ8+T cells in thymus of offspring newborn rats after 0 to 3 days of delivery significantly decreased in SEB group(P<0.05 to P<0.01),and the difference of which in thymus of offspring newborn rats after 4 to 5 days of delivery between two groups was not statistically significnat(P>0.05).In the thymus of offspring newborn rats after 0 to 5 days of delivery,the percentage of CD8+ TCR Vβ8+ T cells in SEB group was significantly lower than that in control group(P<0.05 to P<0.01),and the absolute number of CD4+Vβ8+ and CD8+Vβ8+ T cells in SEB group significantly decreased compared with the control group(P<0.01).In the peripheral blood of offspring newborn rats after 0 to 5 days of delivery,the percentages of the CD4+ Vβ8+ and CD8+ Vβ8+ T cells,and the absolute number of CD4+ Vβ8+ and CD8+ Vβ8+ T cells in SEB group significantly decreased compared with the control group(P<0.05 to P<0.01).Conclusions:Maternal SEB administration during pregnancy can decrease the levels of TCR Vβ8+T cells in the thymus and peripheral blood of offspring newborn rats,and which can continue into adulthood.
2017, 42(3): 285-289.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.002
Abstract:
Objective:To study the effects of the sorafenib combined with 5-nitrogen impurity-2'-deoxy cytidine on human hepatocellular carcinoma SMMC-7721 cells,and investigate the possible molecular mechanism of regulating the DNMT3B gene expression.Methods:After separate and combined medication,the proliferation,invasion and apoptosis of SMMC-7721 cells were detected using MTT method,transwell method and flow cytometry,respectively.The protein expressions of DNMT3B,p-Akt -Ser473 and ERK were measured using Western blotting.Results:The IC50 of sorafenib and 5-nitrogen impurity-2'-deoxy cytidine to hepatocellular carcinoma SMMC-7721 cells were 11 μmol/L and 6 μmol/L respectively.The 6 μmol/L of sorafenib combined with 4 μmol/L of 5-nitrogen impurity-2'-deoxy cytidine was used as the subsequent drug concentration.Compared with the control group,the separate and combined medication could inhibit the cell invasion,promote apoptosis and reduce the protein expressions of p-Akt-Ser473 and DNMT3B(P< 0.05 to P< 0.01).Conclusions:The combined medication of Sorafenib with 5-nitrogen impurity-2'-deoxy cytidine can effectively reduce the sorafenib drug concentration and the protein expression levels of DNMT3B in hepatocellular carcinoma SMMC-7721 cells.
Objective:To study the effects of the sorafenib combined with 5-nitrogen impurity-2'-deoxy cytidine on human hepatocellular carcinoma SMMC-7721 cells,and investigate the possible molecular mechanism of regulating the DNMT3B gene expression.Methods:After separate and combined medication,the proliferation,invasion and apoptosis of SMMC-7721 cells were detected using MTT method,transwell method and flow cytometry,respectively.The protein expressions of DNMT3B,p-Akt -Ser473 and ERK were measured using Western blotting.Results:The IC50 of sorafenib and 5-nitrogen impurity-2'-deoxy cytidine to hepatocellular carcinoma SMMC-7721 cells were 11 μmol/L and 6 μmol/L respectively.The 6 μmol/L of sorafenib combined with 4 μmol/L of 5-nitrogen impurity-2'-deoxy cytidine was used as the subsequent drug concentration.Compared with the control group,the separate and combined medication could inhibit the cell invasion,promote apoptosis and reduce the protein expressions of p-Akt-Ser473 and DNMT3B(P< 0.05 to P< 0.01).Conclusions:The combined medication of Sorafenib with 5-nitrogen impurity-2'-deoxy cytidine can effectively reduce the sorafenib drug concentration and the protein expression levels of DNMT3B in hepatocellular carcinoma SMMC-7721 cells.
2017, 42(3): 289-292.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.003
Abstract:
Objective:To investigate the origin,running pattern,branching type and inner diameter of the maxillary artery,and provide the anatomic basis in the diagnosis and treatment of the related area of maxillary artery.Methods:A total of 15 Chinese cadavers were observed and analyzed in 28 sides.The course of maxillary artery and the regularity of each branch were analyzed.Simultaneous measurement of the origin and diameter of the maxillary artery.Results:The lateral running in 27 sides and inside running in 1 side of maxillary artery were found.The vertical height from the maxillary artery origin to the superior margin of the external auditory canal was(23.4±5.1)mm,and the left vertical height was(22.6±4.5)mm.The branching order in 19 sides(67.9%) was standard type.The length variations of inferior alveolar artery and anterior deep temporal artery were the smallest.The middle meningeal artery and buccal artery were the largest luminal diameter and smallest vessel,respectively.Conclusions:The origin,running pattern,branching type and inner diameter of the maxillary artery can act as an indicator,which can improve the accuracy of image diagnosis,and provide some theory basis in super-selective intra-arterial chemotherapy.
Objective:To investigate the origin,running pattern,branching type and inner diameter of the maxillary artery,and provide the anatomic basis in the diagnosis and treatment of the related area of maxillary artery.Methods:A total of 15 Chinese cadavers were observed and analyzed in 28 sides.The course of maxillary artery and the regularity of each branch were analyzed.Simultaneous measurement of the origin and diameter of the maxillary artery.Results:The lateral running in 27 sides and inside running in 1 side of maxillary artery were found.The vertical height from the maxillary artery origin to the superior margin of the external auditory canal was(23.4±5.1)mm,and the left vertical height was(22.6±4.5)mm.The branching order in 19 sides(67.9%) was standard type.The length variations of inferior alveolar artery and anterior deep temporal artery were the smallest.The middle meningeal artery and buccal artery were the largest luminal diameter and smallest vessel,respectively.Conclusions:The origin,running pattern,branching type and inner diameter of the maxillary artery can act as an indicator,which can improve the accuracy of image diagnosis,and provide some theory basis in super-selective intra-arterial chemotherapy.
2017, 42(3): 293-296.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.004
Abstract:
Objective:To evaluate the clinical significance of serum cystatin C(Cys-C) level in patients with diabetes mellitus complicated with renal disfunction.Methods:The gender,age,course of disease,blood pressure,height and quality of 225 patients with diabetes mellitus were recorded,the body mass index(BMI) was calculated,and glomerular filtration rate(GFR)(mL·min-1·1.73 m-2) was detected using Kidney dynamic imaging.All patients were divided into the group A(GFR<60),group B(60 ≤ GFR<90) and group C(GFR ≥ 90).The levels of serum Cys-C,serum retinol binding protein(RBP),serum creatinine(Scr),blood urea(Sur),blood uric acid(UA),24 hour urine microalbumin(UmAlb) in three groups were detected.Results:The differences of the age,course of disease,and the levels of Scr,Sur,UA,RBP,Cys-C and UmAlb between three groups were statistically significant(P<0.05).The age,course of disease,and the levels of Scr,Sur,UA,RBP,Cys-C and UmAlb were negative correlation with GFR in three groups(P<0.01).The multiple stepwise regression analysis showed that the Cys-C,age,umalb entered the best equation,and serum Cys-C was the first.Conclusions:The Cys-C,age,UmAlb are the main influencing factors of GFR in patients with diabetes mellitus.The serum Cys-C is more ideal and sensitive conventional index in reflecting the early renal disfunction,which can help the early prevention and treatment of diabetic renal disease.
Objective:To evaluate the clinical significance of serum cystatin C(Cys-C) level in patients with diabetes mellitus complicated with renal disfunction.Methods:The gender,age,course of disease,blood pressure,height and quality of 225 patients with diabetes mellitus were recorded,the body mass index(BMI) was calculated,and glomerular filtration rate(GFR)(mL·min-1·1.73 m-2) was detected using Kidney dynamic imaging.All patients were divided into the group A(GFR<60),group B(60 ≤ GFR<90) and group C(GFR ≥ 90).The levels of serum Cys-C,serum retinol binding protein(RBP),serum creatinine(Scr),blood urea(Sur),blood uric acid(UA),24 hour urine microalbumin(UmAlb) in three groups were detected.Results:The differences of the age,course of disease,and the levels of Scr,Sur,UA,RBP,Cys-C and UmAlb between three groups were statistically significant(P<0.05).The age,course of disease,and the levels of Scr,Sur,UA,RBP,Cys-C and UmAlb were negative correlation with GFR in three groups(P<0.01).The multiple stepwise regression analysis showed that the Cys-C,age,umalb entered the best equation,and serum Cys-C was the first.Conclusions:The Cys-C,age,UmAlb are the main influencing factors of GFR in patients with diabetes mellitus.The serum Cys-C is more ideal and sensitive conventional index in reflecting the early renal disfunction,which can help the early prevention and treatment of diabetic renal disease.
2017, 42(3): 297-301.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.005
Abstract:
Objective:To investigate the expressions of the matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase inhibitor-2(TIMP-2) in esophageal squamous cell carcinoma(ESCC),and its correlations with the recurrence,metastasis and prognosis of tumor.Methods:The expressions of MMP-2 and TIMP-2 in tumor tissue of the postoperative patients with ESCC were detected using the immunohistochemistry with Tissue Chip technique.The patients without recurrence and metastasis survived for over 5 years(group A),the patients with recurrence and metastasis died within 1 year(group B).Results:The squamous epithelium of the normal esophagus did not express or expressed little MMP-2 and TIMP-2.The expressions of MMP-2 and TIMP-2 in ESCC tissue were identified,but the expression levels of MMP-2 and TIMP-2 in group B were significantly higher than those in group A(P< 0.01).The expression levels of MMP-2 and TIMP-2 were correlated with the tumor differentiation and lymph node metastasis(P<0.05 and P<0.01).The expression level of TIMP-2 was positively correlated with the MMP-2(P<0.01).Conclusions:MMP-2 and TIMP-2 are overexpressed in esophageal carcinoma tissue,and which are significantly correlated with the recurrence or metastasis of tumor after esophagectomy.The combined detection of MMP-2 and TIMP-2 has important value in predicting the recurrence or metastasis of tumor after operation of ESCC.
Objective:To investigate the expressions of the matrix metalloproteinase-2(MMP-2) and matrix metalloproteinase inhibitor-2(TIMP-2) in esophageal squamous cell carcinoma(ESCC),and its correlations with the recurrence,metastasis and prognosis of tumor.Methods:The expressions of MMP-2 and TIMP-2 in tumor tissue of the postoperative patients with ESCC were detected using the immunohistochemistry with Tissue Chip technique.The patients without recurrence and metastasis survived for over 5 years(group A),the patients with recurrence and metastasis died within 1 year(group B).Results:The squamous epithelium of the normal esophagus did not express or expressed little MMP-2 and TIMP-2.The expressions of MMP-2 and TIMP-2 in ESCC tissue were identified,but the expression levels of MMP-2 and TIMP-2 in group B were significantly higher than those in group A(P< 0.01).The expression levels of MMP-2 and TIMP-2 were correlated with the tumor differentiation and lymph node metastasis(P<0.05 and P<0.01).The expression level of TIMP-2 was positively correlated with the MMP-2(P<0.01).Conclusions:MMP-2 and TIMP-2 are overexpressed in esophageal carcinoma tissue,and which are significantly correlated with the recurrence or metastasis of tumor after esophagectomy.The combined detection of MMP-2 and TIMP-2 has important value in predicting the recurrence or metastasis of tumor after operation of ESCC.
2017, 42(3): 302-304,308.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.006
Abstract:
Objective:To evaluate the clinical efficacy of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster,and investigate the influencing factors of postherpetic neuralgia(PHN).Methods:One hundred and eighty-two patients with acute herpes zoster were randomly divided into the observation group(77 cases treated with vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics) and control group(106 cases treated with vidarabine monophosphate combined with narrow-band ultraviolet).The indicators of herpes,visual analogue scale(VAS) score,comprehensive curative effects and incidence rates of postherpetic neuralgia between two groups were analyzed.Results:The times of response,scab form and decrustation in observation group were significantly shorter than those in control group(P<0.01).The VAS score after 10 days of treatment in observation group was lower than that in control group(P<0.01).The total effective rate in observation group was higher than that in control group(P<0.05),and the incidence rates of PHN at 1 month or 3 months of treatment in observation group were lower than that in control group(P<0.05).Multivariate logistic regression analysis showed that the age and VAS score before treatment were the independent risk factor of PHN(P<0.05 to P<0.01).Conclusions:The effect of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster is significant,which can prevent the incidence of PHN.
Objective:To evaluate the clinical efficacy of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster,and investigate the influencing factors of postherpetic neuralgia(PHN).Methods:One hundred and eighty-two patients with acute herpes zoster were randomly divided into the observation group(77 cases treated with vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics) and control group(106 cases treated with vidarabine monophosphate combined with narrow-band ultraviolet).The indicators of herpes,visual analogue scale(VAS) score,comprehensive curative effects and incidence rates of postherpetic neuralgia between two groups were analyzed.Results:The times of response,scab form and decrustation in observation group were significantly shorter than those in control group(P<0.01).The VAS score after 10 days of treatment in observation group was lower than that in control group(P<0.01).The total effective rate in observation group was higher than that in control group(P<0.05),and the incidence rates of PHN at 1 month or 3 months of treatment in observation group were lower than that in control group(P<0.05).Multivariate logistic regression analysis showed that the age and VAS score before treatment were the independent risk factor of PHN(P<0.05 to P<0.01).Conclusions:The effect of vidarabine monophosphate,narrow-band ultraviolet combined with and LED photodynamics in the treatment of herpes zoster is significant,which can prevent the incidence of PHN.
2017, 42(3): 305-308.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.007
Abstract:
Objective:To detect the level of serum sex hormone binding globulin(SHBG) in type 2 diabetes mellitus(T2DM) patients,and investigate the relationships between SHBG and insulin resistance,glucose metabolism.Methods:The levels of SHBG,fasting plasma glucose(FPG),fasting insulin(FINS),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) and glycated hemoglobin(HbA1c) in 122 T2DM patients and 80 healthy people detected and analyzed.Results:The serum SHBG level in T2DM patients was significantly lower than that in healthy people(P<0.01).The serum SHBG level was negatively associated with the levels of HOMA-IR,HbA1c,TG,FPG and FINS(r=-0.417,-0.283,-0.305,-0.301,-0.236,P<0.01),and positively associated with HDL-C level and age(r=0.342,0.456,P<0.01).Binary logistic regression analysis showed that SHBG was a protective factor in T2DM(OR=0.965,95%CI 0.934 to 0.998,β=-0.035,P=0.036).Multiple linear regression analysis showed that the SHBG,and HOMA-IR,age and HDL-C were linear regression relation(β=-0.295,0.313,0.238,P<0.01,P<0.01,P<0.05).Conclusions:The serum SHBG level decreasing in T2DM patients may be an independent risk factor of T2DM.
Objective:To detect the level of serum sex hormone binding globulin(SHBG) in type 2 diabetes mellitus(T2DM) patients,and investigate the relationships between SHBG and insulin resistance,glucose metabolism.Methods:The levels of SHBG,fasting plasma glucose(FPG),fasting insulin(FINS),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C) and glycated hemoglobin(HbA1c) in 122 T2DM patients and 80 healthy people detected and analyzed.Results:The serum SHBG level in T2DM patients was significantly lower than that in healthy people(P<0.01).The serum SHBG level was negatively associated with the levels of HOMA-IR,HbA1c,TG,FPG and FINS(r=-0.417,-0.283,-0.305,-0.301,-0.236,P<0.01),and positively associated with HDL-C level and age(r=0.342,0.456,P<0.01).Binary logistic regression analysis showed that SHBG was a protective factor in T2DM(OR=0.965,95%CI 0.934 to 0.998,β=-0.035,P=0.036).Multiple linear regression analysis showed that the SHBG,and HOMA-IR,age and HDL-C were linear regression relation(β=-0.295,0.313,0.238,P<0.01,P<0.01,P<0.05).Conclusions:The serum SHBG level decreasing in T2DM patients may be an independent risk factor of T2DM.
2017, 42(3): 309-312,316.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.008
Abstract:
Objective:To investigate the clinical manifestations and imaging features of cerebral venous sinus thrombosis(CVST).Methods:The clinical manifestations and imaging features of CVST in 80 cases were retrospectively analyzed.Results:Among 80 patients diagnosed by CVST,acute onset(<1 week) in 38 cases,subacute onset(1 week to 1 month) in 31 cases and chronic onset(>1 month) in 11 cases were identified.Headache was the first symptom.Thirty-two cases involved in single venous sinus,and 48 cases involved in multiple sinuses.The display rates of direct sign and indirect sign in brain CT were 15.00% and 21.25%,respectively.The positive rate of brain MRI/MRV was 100%.Seventy-two cases were treated with low molecular weight heparin calcium,the effective rate was 85.00%,and recurrence rate was 1.25%.Conclusions:CVST often occures in young people and middle-aged,which has various types of onset and complex causes.Infection,puerperal and oral contraceptive are the most common causes.Headache is the most common and first symptom.The clinical symptom of CVST lacks the specificity,and the clinical symptoms combined with brain MRI/MRV can definitely diagnose.Anticoagulation effect is obvious,and the prognosis is good.
Objective:To investigate the clinical manifestations and imaging features of cerebral venous sinus thrombosis(CVST).Methods:The clinical manifestations and imaging features of CVST in 80 cases were retrospectively analyzed.Results:Among 80 patients diagnosed by CVST,acute onset(<1 week) in 38 cases,subacute onset(1 week to 1 month) in 31 cases and chronic onset(>1 month) in 11 cases were identified.Headache was the first symptom.Thirty-two cases involved in single venous sinus,and 48 cases involved in multiple sinuses.The display rates of direct sign and indirect sign in brain CT were 15.00% and 21.25%,respectively.The positive rate of brain MRI/MRV was 100%.Seventy-two cases were treated with low molecular weight heparin calcium,the effective rate was 85.00%,and recurrence rate was 1.25%.Conclusions:CVST often occures in young people and middle-aged,which has various types of onset and complex causes.Infection,puerperal and oral contraceptive are the most common causes.Headache is the most common and first symptom.The clinical symptom of CVST lacks the specificity,and the clinical symptoms combined with brain MRI/MRV can definitely diagnose.Anticoagulation effect is obvious,and the prognosis is good.
2017, 42(3): 313-316.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.009
Abstract:
Objective:To evaluate the blood perfusion change of cerebral after carotid artery stenting using CT perfusion imaging(CTP).Methods:Twenty-three patients with carotid stenosis were divided into the symptomatic group(n=13) and asymptomatic group(n=10).The medium or severe unilateral internal carotid artery stenosis patients were diagnosed using the cerebral digital subtraction angiography/CT angiography.All patients were treated with the carotid artery stenting,two groups was not,statistically significaat(P>0.05) and examined using brain CTP before operation and after 7 days of operation.The relative regional cerebral blood flow(rCBF),relative regional cerebral blood volume(rCBV),relative regional mean transit time(rMTT) and relative regional time to peak(rTTP) between two groups were compared after 7 days of operation.Results:The postoperative time of rTTP and rMTT shortened,but the diffence between the two groups was not statistically significant(P>0.05),the postoperative time of rCBF,rCBV was statistically significant(P<0.05 to P<0.01).Compared with the healthy side,the time of rTTP and rCBV prolonged,and the time of rCBF increased in affected side(P<0.01).The difference of the time of rCBV between the healthy side and affected side was not statistically significant(P>0.05).The CTP imaging after 7 days of operation showed the differences of the time of rCBF and rCBV between the healthy side and affected side were not statistically significant(P>0.05).The rTTP and rMTT in affected side were improved after operation(P<0.05 and P<0.01),and which obviously delayed compared with the healthy side(P<0.05).Conclusions:The CTP maybe accurately reflect the cerebral hemodynamic status in patients with carotid artery stenosis before and after stenting,which can be used as a noninvasive evaluating method for cerebral hemodynamic change after carotid artery stenting.The rTTP is a very sensitive index for evaluating early ischemia and compensator capacity of collateral circulation.
Objective:To evaluate the blood perfusion change of cerebral after carotid artery stenting using CT perfusion imaging(CTP).Methods:Twenty-three patients with carotid stenosis were divided into the symptomatic group(n=13) and asymptomatic group(n=10).The medium or severe unilateral internal carotid artery stenosis patients were diagnosed using the cerebral digital subtraction angiography/CT angiography.All patients were treated with the carotid artery stenting,two groups was not,statistically significaat(P>0.05) and examined using brain CTP before operation and after 7 days of operation.The relative regional cerebral blood flow(rCBF),relative regional cerebral blood volume(rCBV),relative regional mean transit time(rMTT) and relative regional time to peak(rTTP) between two groups were compared after 7 days of operation.Results:The postoperative time of rTTP and rMTT shortened,but the diffence between the two groups was not statistically significant(P>0.05),the postoperative time of rCBF,rCBV was statistically significant(P<0.05 to P<0.01).Compared with the healthy side,the time of rTTP and rCBV prolonged,and the time of rCBF increased in affected side(P<0.01).The difference of the time of rCBV between the healthy side and affected side was not statistically significant(P>0.05).The CTP imaging after 7 days of operation showed the differences of the time of rCBF and rCBV between the healthy side and affected side were not statistically significant(P>0.05).The rTTP and rMTT in affected side were improved after operation(P<0.05 and P<0.01),and which obviously delayed compared with the healthy side(P<0.05).Conclusions:The CTP maybe accurately reflect the cerebral hemodynamic status in patients with carotid artery stenosis before and after stenting,which can be used as a noninvasive evaluating method for cerebral hemodynamic change after carotid artery stenting.The rTTP is a very sensitive index for evaluating early ischemia and compensator capacity of collateral circulation.
2017, 42(3): 317-319,322.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.010
Abstract:
Objective:To investigate the relationship between APACHE Ⅱ score and weaning outcome of mechanical ventilation in patients with severe pneumonia.Methods:The APACHE Ⅱ scores of 45 severe pneumonia patients treated with mechanical ventilation were obtained before spontaneous breathing test(SBT) at the first day of admission and according with weaning standard.According to the weaning outcome,the patients were divided into the observation group(35 cases) and control group(10 cases).The observation group did not need ventilator-assisted ventilation after 48 hours of pulling tracheal intubation,and the control group need reintubation to recover ventilator-assisted ventilation within 48 hours of extubation and after the SBT failure.The APACHE Ⅱ score at the first day of admission and before weaning,and mechanical ventilation time before SBT between two groups were compared.The receiver operating characteristic curve (ROC curve) was drew,and the area under curve(AUC) was calculated.The APACHE Ⅱ score was used to predict the weaning outcome.Results:The differences of the APACHE Ⅱ score at the first day of admission,mechanical ventilation time before SBT and APACHE Ⅱ score before weaning between two groups were not statistically significant(P>0.05).The AUC of the ROC curve of APACHE Ⅱ score was 0.871,the best cut-off value was the APACHE Ⅱ for 10.1,and the sensitivity and specificity was 90.6% and 53.8%,respectively.Conclusions:APACHE Ⅱ score has a certain value in predicting the outcome of severe pneumonia,and can be used as a reference index in weaning of mechanical ventilation.
Objective:To investigate the relationship between APACHE Ⅱ score and weaning outcome of mechanical ventilation in patients with severe pneumonia.Methods:The APACHE Ⅱ scores of 45 severe pneumonia patients treated with mechanical ventilation were obtained before spontaneous breathing test(SBT) at the first day of admission and according with weaning standard.According to the weaning outcome,the patients were divided into the observation group(35 cases) and control group(10 cases).The observation group did not need ventilator-assisted ventilation after 48 hours of pulling tracheal intubation,and the control group need reintubation to recover ventilator-assisted ventilation within 48 hours of extubation and after the SBT failure.The APACHE Ⅱ score at the first day of admission and before weaning,and mechanical ventilation time before SBT between two groups were compared.The receiver operating characteristic curve (ROC curve) was drew,and the area under curve(AUC) was calculated.The APACHE Ⅱ score was used to predict the weaning outcome.Results:The differences of the APACHE Ⅱ score at the first day of admission,mechanical ventilation time before SBT and APACHE Ⅱ score before weaning between two groups were not statistically significant(P>0.05).The AUC of the ROC curve of APACHE Ⅱ score was 0.871,the best cut-off value was the APACHE Ⅱ for 10.1,and the sensitivity and specificity was 90.6% and 53.8%,respectively.Conclusions:APACHE Ⅱ score has a certain value in predicting the outcome of severe pneumonia,and can be used as a reference index in weaning of mechanical ventilation.
2017, 42(3): 320-322.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.011
Abstract:
Objective:To analyze the correlation of obesity degree with serum neuropeptide Y(NPY) level in patients with obstructive sleep apnea hypopnea syndrome(OSAHS),its influence on OSAHS disease and night change of the NPY level,and provide the theoretical basis for the clinical treatment of OSAHS.Methods:Patients aged from 40 to 65 years old were divided into OSAHS group(140 cases) and non-OSAHS group(35 cases).According to the body mass,the OSAHS group were further subdivided into the mild obesity group,moderate obesity group,severe obesity group and normal body mass group(35 cases each group).The breath disorder index and lowest oxygen saturation(LSaO2) in all cases were recorded using the night polysomnogram evaluation for at least 7 hours.The body weight,body mass,neck circumference and ratio of waist to hip of all cases were analyzed.Results:The serum NPY levels of OSAHS patients in obesity group were higher than that in non-OSAHS group and mild OSAHS group(P<0.01),and which in severe OSAHS group was higher than that in moderate group and mild group(P<0.01).Among the OSAHS patients,the NPY level was positively and negatively correlated to the breath disorder index and body mass coefficient,respectively(P<0.01).The NPY level in OSAHS patients was negatively and positively correlated to the neck circumference and ratio of waist to hip,respectively(P<0.01).Conclusions:The serum NPY level in OSAHS patients is correlated to the severity of OSAHS and obesity degree,and which increases with the aggravating of OSAHS severity.
Objective:To analyze the correlation of obesity degree with serum neuropeptide Y(NPY) level in patients with obstructive sleep apnea hypopnea syndrome(OSAHS),its influence on OSAHS disease and night change of the NPY level,and provide the theoretical basis for the clinical treatment of OSAHS.Methods:Patients aged from 40 to 65 years old were divided into OSAHS group(140 cases) and non-OSAHS group(35 cases).According to the body mass,the OSAHS group were further subdivided into the mild obesity group,moderate obesity group,severe obesity group and normal body mass group(35 cases each group).The breath disorder index and lowest oxygen saturation(LSaO2) in all cases were recorded using the night polysomnogram evaluation for at least 7 hours.The body weight,body mass,neck circumference and ratio of waist to hip of all cases were analyzed.Results:The serum NPY levels of OSAHS patients in obesity group were higher than that in non-OSAHS group and mild OSAHS group(P<0.01),and which in severe OSAHS group was higher than that in moderate group and mild group(P<0.01).Among the OSAHS patients,the NPY level was positively and negatively correlated to the breath disorder index and body mass coefficient,respectively(P<0.01).The NPY level in OSAHS patients was negatively and positively correlated to the neck circumference and ratio of waist to hip,respectively(P<0.01).Conclusions:The serum NPY level in OSAHS patients is correlated to the severity of OSAHS and obesity degree,and which increases with the aggravating of OSAHS severity.
2017, 42(3): 323-325.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.012
Abstract:
Objective:To investigate the electrocardiogram(ECG) of patients with late diastolic premature ventricular contraction in sinus rhythm before and after radiofrequency catheter ablation,and analyze the effects of different bypass prequels on the PJ intervals.Methods:A total of 120 cases with late diastolic premature ventricular contraction in sinus rhythm diagnosed by dynamic electrocardiogram were divided into 10 groups according to the bypass.Twelve lead synchronous ECG were scanned before and after radiofrequency catheter ablation,and the PR interval,PJ interval,QRS interval and δ wave time were measured.Results:Compared with before operation,the postoperative PJ intervals in LPS,RA,RP,RAS,RMS and RPS group significantly prolonged(P< 0.05),and the differences of the postoperative PJ intervals between other groups were not statistically significant(P>0.05).The ECG results showed that the postoperative PR intervals in LL,LPS,RA and RP group significantly prolonged compared with before operation(P< 0.05 to P<0.01),and the differences of the postoperative PR intervals between other groups were not statistically significant(P>0.05).The postoperative QRS intervals in LPS,RL,RP,RAS,RMS and RPS groups were longer than those before operation(P<0.05 to P<0.01),and the differences of the postoperative GRS intervals between other groups were not statistically significant(P>0.05).The differences of the δ wave times in all groups before operation were not statistically significant(P>0.05).Conclusions:The PJ interval shortening of ECG has important clinical value between contraction in sinus rhythm and intermittent preexcitation syndrome,which is worthy of promotion in primary hospital,and helpful for the ECG diagnosis and differential diagnosis of late diastolic ventricular premature contraction in sinus rhythm.
Objective:To investigate the electrocardiogram(ECG) of patients with late diastolic premature ventricular contraction in sinus rhythm before and after radiofrequency catheter ablation,and analyze the effects of different bypass prequels on the PJ intervals.Methods:A total of 120 cases with late diastolic premature ventricular contraction in sinus rhythm diagnosed by dynamic electrocardiogram were divided into 10 groups according to the bypass.Twelve lead synchronous ECG were scanned before and after radiofrequency catheter ablation,and the PR interval,PJ interval,QRS interval and δ wave time were measured.Results:Compared with before operation,the postoperative PJ intervals in LPS,RA,RP,RAS,RMS and RPS group significantly prolonged(P< 0.05),and the differences of the postoperative PJ intervals between other groups were not statistically significant(P>0.05).The ECG results showed that the postoperative PR intervals in LL,LPS,RA and RP group significantly prolonged compared with before operation(P< 0.05 to P<0.01),and the differences of the postoperative PR intervals between other groups were not statistically significant(P>0.05).The postoperative QRS intervals in LPS,RL,RP,RAS,RMS and RPS groups were longer than those before operation(P<0.05 to P<0.01),and the differences of the postoperative GRS intervals between other groups were not statistically significant(P>0.05).The differences of the δ wave times in all groups before operation were not statistically significant(P>0.05).Conclusions:The PJ interval shortening of ECG has important clinical value between contraction in sinus rhythm and intermittent preexcitation syndrome,which is worthy of promotion in primary hospital,and helpful for the ECG diagnosis and differential diagnosis of late diastolic ventricular premature contraction in sinus rhythm.
2017, 42(3): 326-328,331.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.013
Abstract:
Objective:To investigate the efficacy and safety of the latanoprost in the treatment of ocular hypertension and open angle glaucoma(POAG).Methods:Using a randomized single blind controlled trial,80 patients(80 eyes) with ocular hypertension or POAG were randomly divided into the observation group and control group(40 cases each group).The observation group and control group were treated with latanoprost and travoprost,once a day,for 4 weeks,respectively.The clinical efficacy in 2 groups were observed.Results:The differences of intraocular pressure(IOP) before treatment and after 1,2,3 and 4 weeks of treatment between two groups were not statistically significant(P>0.05).Compared with before treatment,the IOP in 2 groups after 1,2,3 and 4 weeks of treatment significantly decreased(P<0.01).Compared with before treatment,the IOP in 2 groups at 8 and 11 o'clock in the morning,and 2 and 4 o'clock in the afternoon significantly decreased after treatment(P<0.01),and the differences of the IOP in 2 groups at 8 and 11 o'clock in the morning,and 2 and 4 o'clock between before and after treatment were not statistically significant(P>0.05).The differences of the mean defect of visual field,central corneal thickness and Schirmer value before treatment,and BUT value before and after treatment between two groups were not statistically significant(P>0.05).After treatment,the mean defect of visual field and Schirmer value in observation group were lower than that in control group(P<0.05 and P<0.01),and the central corneal thickness in observation group was higher than that in control group(P<0.01).During the treatment,the differences of the incidence rate of the conjunctival congestion,ngeyan,eye pain and burning sensation between two groups were not statistically significant(P>0.05).Conclusions:The effects of latanoprost and travoprost in the treatment of ocular hypertension and POAG are good,the adverse reaction between latanoprost and travoprost is similar.
Objective:To investigate the efficacy and safety of the latanoprost in the treatment of ocular hypertension and open angle glaucoma(POAG).Methods:Using a randomized single blind controlled trial,80 patients(80 eyes) with ocular hypertension or POAG were randomly divided into the observation group and control group(40 cases each group).The observation group and control group were treated with latanoprost and travoprost,once a day,for 4 weeks,respectively.The clinical efficacy in 2 groups were observed.Results:The differences of intraocular pressure(IOP) before treatment and after 1,2,3 and 4 weeks of treatment between two groups were not statistically significant(P>0.05).Compared with before treatment,the IOP in 2 groups after 1,2,3 and 4 weeks of treatment significantly decreased(P<0.01).Compared with before treatment,the IOP in 2 groups at 8 and 11 o'clock in the morning,and 2 and 4 o'clock in the afternoon significantly decreased after treatment(P<0.01),and the differences of the IOP in 2 groups at 8 and 11 o'clock in the morning,and 2 and 4 o'clock between before and after treatment were not statistically significant(P>0.05).The differences of the mean defect of visual field,central corneal thickness and Schirmer value before treatment,and BUT value before and after treatment between two groups were not statistically significant(P>0.05).After treatment,the mean defect of visual field and Schirmer value in observation group were lower than that in control group(P<0.05 and P<0.01),and the central corneal thickness in observation group was higher than that in control group(P<0.01).During the treatment,the differences of the incidence rate of the conjunctival congestion,ngeyan,eye pain and burning sensation between two groups were not statistically significant(P>0.05).Conclusions:The effects of latanoprost and travoprost in the treatment of ocular hypertension and POAG are good,the adverse reaction between latanoprost and travoprost is similar.
2017, 42(3): 329-331.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.014
Abstract:
Objective:To explore the clinical effects of Irbesartan in the treatment of essential hypertension complicated with left ventricular hypertrophy.Methods:One hundred and five patients with essential hypertension complicated with left ventricular hypertrophy were randomly divided into the control group and treatment group.The control group were treated with Benazepril hydrochloride by oral,10 mg/d for 6 months,and the treatment group were treated with Irbesartan by oral,150 mg/d for 6 months.The blood pressure,left ventricular end-diastolic interventricular septum thickness(LVST),left ventricular end-diastolic wall thickness(LVPWT),left ventricular end-diastolic cavity diameter(LVED),left ventricular ejection fraction(LVEF)and other cardiac function and clinical efficacy before and after treatment between two groups were compared.Results:Compared with before treatment,the blood pressure,LVST,LVPWT and LVED in two groups significantly decreased after 6 months of treatment(P<0.05),and the decreasing degrees of whose in treatment group were significantly more than those in control group after treatment(P<0.05).The LVEF in treatment group after treatment was significantly higher than that in treatment group before treatment and control group after treatment(P<0.05).The difference of clinical efficacy between two groups was no statistically significant(P<0.05).Conclusions:Both Irbesartan and Benazepril can effectively reduce the blood pressure,reverse left ventricular hypertrophy and improve left ventricular diastolic function,and the treatment efffect of Irbesartan is more significant.
Objective:To explore the clinical effects of Irbesartan in the treatment of essential hypertension complicated with left ventricular hypertrophy.Methods:One hundred and five patients with essential hypertension complicated with left ventricular hypertrophy were randomly divided into the control group and treatment group.The control group were treated with Benazepril hydrochloride by oral,10 mg/d for 6 months,and the treatment group were treated with Irbesartan by oral,150 mg/d for 6 months.The blood pressure,left ventricular end-diastolic interventricular septum thickness(LVST),left ventricular end-diastolic wall thickness(LVPWT),left ventricular end-diastolic cavity diameter(LVED),left ventricular ejection fraction(LVEF)and other cardiac function and clinical efficacy before and after treatment between two groups were compared.Results:Compared with before treatment,the blood pressure,LVST,LVPWT and LVED in two groups significantly decreased after 6 months of treatment(P<0.05),and the decreasing degrees of whose in treatment group were significantly more than those in control group after treatment(P<0.05).The LVEF in treatment group after treatment was significantly higher than that in treatment group before treatment and control group after treatment(P<0.05).The difference of clinical efficacy between two groups was no statistically significant(P<0.05).Conclusions:Both Irbesartan and Benazepril can effectively reduce the blood pressure,reverse left ventricular hypertrophy and improve left ventricular diastolic function,and the treatment efffect of Irbesartan is more significant.
2017, 42(3): 332-334.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.015
Abstract:
Objective:To investigate the clinical and pathological characteristics of papillary thyroid carcinoma(PTC) complicated with hashimoto thyroiditis(HT).Methods:Forty-three patients with PTC complicated with HT and 45 patients with PTC were divided into the observation and control group,respectively.The clinical and pathological characteristics between two groups were compared.Results:The thyroid enlargement and neck compression symptoms in observation group were more than those in control group(P<0.05).The differences of the goiter,neck pain,hoarseness and swallowing difficulty between two groups were not statistically significant(P>0.05).The proportion of female and less than or equal to 44 years old patients in observation group were significantly higher than those in control group(P<0.05).The differences of lymph node metastasis,clinical stage,tumor type,number of cancer lesion and prognosis between two groups were statistically significant(P<0.05).Conclusions:Compared with the PTC patients,the thyroid enlargement and neck compression symptom in PTC complicated with HT patients are more common.The young middle-aged people female,less lymph node metastasis,earlier clinical stage and better prognosis are the main clinical characteristics.
Objective:To investigate the clinical and pathological characteristics of papillary thyroid carcinoma(PTC) complicated with hashimoto thyroiditis(HT).Methods:Forty-three patients with PTC complicated with HT and 45 patients with PTC were divided into the observation and control group,respectively.The clinical and pathological characteristics between two groups were compared.Results:The thyroid enlargement and neck compression symptoms in observation group were more than those in control group(P<0.05).The differences of the goiter,neck pain,hoarseness and swallowing difficulty between two groups were not statistically significant(P>0.05).The proportion of female and less than or equal to 44 years old patients in observation group were significantly higher than those in control group(P<0.05).The differences of lymph node metastasis,clinical stage,tumor type,number of cancer lesion and prognosis between two groups were statistically significant(P<0.05).Conclusions:Compared with the PTC patients,the thyroid enlargement and neck compression symptom in PTC complicated with HT patients are more common.The young middle-aged people female,less lymph node metastasis,earlier clinical stage and better prognosis are the main clinical characteristics.
2017, 42(3): 335-339.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.016
Abstract:
Objective:To observe the clinical effects between three kinds of repairs of nasal septum perforation and nasal ventilation function change.Methods:Fifty-four patients with nasal septum perforation were divided into A,B and C groups.The A,B and C groups were treated with autologous temporal fascia and perpendicular plate of ethmoid bone sandwich technique,autograft with pedicle nasal mucoperiosteal flap repair method,and single pedicle sticky periosteum or perichondrium flip flap combined with free temporalis myofascial flap repair method,respectively.The treatment effects and postoperative nasal ventilation function in three groups were observed.Results:The intraoperative blood loss and operation time in group B were significantly lower than those in A and C groups(P<0.05 to P<0.01).The mucosal injury area and wound healing time in B and C groups were significantly better than those in group A(P<0.05).The wound healing time in group C was shorter than that in group B(P<0.05),and the differences of the healing stage between the three groups were not statistically significant(P>0.05).The minimal cross-sectional area of nasal cavity in group C at postoperative 3 months and 1 year were significantly higher than that in A and B groups.Conclusions:The clinical effect of the single pedicle sticky periosteum or perichondrium flip flap combined with free temporal fascia flap repair method in the treatment of nasal septum perforation is good,which in improving the nasal ventilation function is better than that in autologous temporal fascia and perpendicular plate of ethmoid bone sandwich technique,and autograft with pedicle nasal mucoperiosteal flap repair method.
Objective:To observe the clinical effects between three kinds of repairs of nasal septum perforation and nasal ventilation function change.Methods:Fifty-four patients with nasal septum perforation were divided into A,B and C groups.The A,B and C groups were treated with autologous temporal fascia and perpendicular plate of ethmoid bone sandwich technique,autograft with pedicle nasal mucoperiosteal flap repair method,and single pedicle sticky periosteum or perichondrium flip flap combined with free temporalis myofascial flap repair method,respectively.The treatment effects and postoperative nasal ventilation function in three groups were observed.Results:The intraoperative blood loss and operation time in group B were significantly lower than those in A and C groups(P<0.05 to P<0.01).The mucosal injury area and wound healing time in B and C groups were significantly better than those in group A(P<0.05).The wound healing time in group C was shorter than that in group B(P<0.05),and the differences of the healing stage between the three groups were not statistically significant(P>0.05).The minimal cross-sectional area of nasal cavity in group C at postoperative 3 months and 1 year were significantly higher than that in A and B groups.Conclusions:The clinical effect of the single pedicle sticky periosteum or perichondrium flip flap combined with free temporal fascia flap repair method in the treatment of nasal septum perforation is good,which in improving the nasal ventilation function is better than that in autologous temporal fascia and perpendicular plate of ethmoid bone sandwich technique,and autograft with pedicle nasal mucoperiosteal flap repair method.
2017, 42(3): 339-341.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.017
Abstract:
Objective:To detect the olfactory dyfunction condition in patients with early stage Parkinson's disease,and explore the significance of the quantitative olfactory detection in the early diagnosis of PD.Methods:The bilateral nasal olfactory in 45 patients with early stage PD and 49 healthy examinees at the same time were examined using the "five odors olfactory detection arrays".The relationships between the age,disease duration,UPDRS score and Hoehn-Yahr staging,and olfactory were analyzed in patients with PD.Results:The detection threshold and identification threshold of olfactory in patients with Parkinson's disease were significantly higher than those in healthy people(P<0.01).The detection threshold and identification threshold of olfactory were not signficantly correlated with the age,course of disease,UPDRS score and Hoehn-Yahr staging of patients(P>0.05),and the UPDRS score was positively correlated with the disease duration and H-Y staging(P<0.01 and P<0.05).Conclusions:The olfactory dysfunction in patients with early stage PD is found,and bilateral symmetry.The olfactory detection has certain significance in the early diagnosis of PD.
Objective:To detect the olfactory dyfunction condition in patients with early stage Parkinson's disease,and explore the significance of the quantitative olfactory detection in the early diagnosis of PD.Methods:The bilateral nasal olfactory in 45 patients with early stage PD and 49 healthy examinees at the same time were examined using the "five odors olfactory detection arrays".The relationships between the age,disease duration,UPDRS score and Hoehn-Yahr staging,and olfactory were analyzed in patients with PD.Results:The detection threshold and identification threshold of olfactory in patients with Parkinson's disease were significantly higher than those in healthy people(P<0.01).The detection threshold and identification threshold of olfactory were not signficantly correlated with the age,course of disease,UPDRS score and Hoehn-Yahr staging of patients(P>0.05),and the UPDRS score was positively correlated with the disease duration and H-Y staging(P<0.01 and P<0.05).Conclusions:The olfactory dysfunction in patients with early stage PD is found,and bilateral symmetry.The olfactory detection has certain significance in the early diagnosis of PD.
2017, 42(3): 342-344.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.018
Abstract:
Objective:To observe the curative effect of celecoxib in sepsis patients,and explore its possible mechanism.Methods:Fifty-two patients with sepsis were randomly divided into the observation group(28 cases treated with celecoxib) and control group(24 cases treated with traditional method) from March 2010 to November 2014.The data of the general information,the correlated indicators of efficacy and prognosis,and the indicators of infection,inflammation and T cell subsets before and after treatment between two groups were analyzed and compared.Results:The total length of hospital stay and APACHE Ⅱ score in observation group were lower than those in control group after 1 week of treatment(P<0.01).The differences of the indexes of infection,inflammation and T cell subsets before treatment between two groups were not statistically significant(P>0.05),but the levels of WBC,PCT,CRP,TNF-α,IL-1β and IL-6 in observation group were obviously lower than those in control group after 1 week of treatment(P<0.01).After 1 week of treatment,the levels of CD4+ and CD4+/CD8+ T cells in observation group were significantly higher than those in control group,and the level of CD8+ T cells in observation group was lower than that in control group(P<0.01).Conclusions:Celecoxib can significantly inhibit the inflammatory reaction,and improve the immunologic function of T lymphocytes and prognosis of patients with sepsis.
Objective:To observe the curative effect of celecoxib in sepsis patients,and explore its possible mechanism.Methods:Fifty-two patients with sepsis were randomly divided into the observation group(28 cases treated with celecoxib) and control group(24 cases treated with traditional method) from March 2010 to November 2014.The data of the general information,the correlated indicators of efficacy and prognosis,and the indicators of infection,inflammation and T cell subsets before and after treatment between two groups were analyzed and compared.Results:The total length of hospital stay and APACHE Ⅱ score in observation group were lower than those in control group after 1 week of treatment(P<0.01).The differences of the indexes of infection,inflammation and T cell subsets before treatment between two groups were not statistically significant(P>0.05),but the levels of WBC,PCT,CRP,TNF-α,IL-1β and IL-6 in observation group were obviously lower than those in control group after 1 week of treatment(P<0.01).After 1 week of treatment,the levels of CD4+ and CD4+/CD8+ T cells in observation group were significantly higher than those in control group,and the level of CD8+ T cells in observation group was lower than that in control group(P<0.01).Conclusions:Celecoxib can significantly inhibit the inflammatory reaction,and improve the immunologic function of T lymphocytes and prognosis of patients with sepsis.
2017, 42(3): 345-347.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.019
Abstract:
Objective:To investigate the effects of different glucose tolerance status during pregnancy on pregnancy outcome.Methods:One thousand seven hundred and one singleton pregnant women were divided into the gestational impaired glucose tolerance group(GIGT group),gestational diabetes mellitus group(GDM group) and euglycemia group(control group) according to the blood sugar status in pregnancy.The data of patients were retrospectively analyzed.Results:The maternal age in GIGT group and GDM group were significantly higher than that in control group(P<0.01).The pre-pregnancy weight,over weight and obesity rates in GDM group were higher than those in control group(P<0.01 and P<0.05).The pre-pregnancy weight in GIGT group was lower than that in GDM group(P<0.01),but the differences of the prenatal weight and BMI between three groups were not statistically significant(P>0.05).The incidence rates of the premature rupture of membrane and polyhydramnios in GIGT and GDM groups were higher than those in control group(P<0.05),the incidence rates of macrosomia and cesarean in GDM group were higher than those in control group(P<0.05),and the incidence rate of cesarean in GIGT group was lower than that in GDM group(P<0.05).The differences of the incidence rates of postpartum hemorrhage between three groups were statistically significant(P<0.01).The differences of the incidence rates of hypertensive disorders in pregnancy,premature birth and hypothyroidism between three groups were not statistically significant(P>0.05).Conclusions:Both GIGT and GDM can harm the health of mothers and children,which should be emphasized.The proper pregnancy and controlling pre-pregnancy weight can reduce the incidences of GDM and GIGT.
Objective:To investigate the effects of different glucose tolerance status during pregnancy on pregnancy outcome.Methods:One thousand seven hundred and one singleton pregnant women were divided into the gestational impaired glucose tolerance group(GIGT group),gestational diabetes mellitus group(GDM group) and euglycemia group(control group) according to the blood sugar status in pregnancy.The data of patients were retrospectively analyzed.Results:The maternal age in GIGT group and GDM group were significantly higher than that in control group(P<0.01).The pre-pregnancy weight,over weight and obesity rates in GDM group were higher than those in control group(P<0.01 and P<0.05).The pre-pregnancy weight in GIGT group was lower than that in GDM group(P<0.01),but the differences of the prenatal weight and BMI between three groups were not statistically significant(P>0.05).The incidence rates of the premature rupture of membrane and polyhydramnios in GIGT and GDM groups were higher than those in control group(P<0.05),the incidence rates of macrosomia and cesarean in GDM group were higher than those in control group(P<0.05),and the incidence rate of cesarean in GIGT group was lower than that in GDM group(P<0.05).The differences of the incidence rates of postpartum hemorrhage between three groups were statistically significant(P<0.01).The differences of the incidence rates of hypertensive disorders in pregnancy,premature birth and hypothyroidism between three groups were not statistically significant(P>0.05).Conclusions:Both GIGT and GDM can harm the health of mothers and children,which should be emphasized.The proper pregnancy and controlling pre-pregnancy weight can reduce the incidences of GDM and GIGT.
2017, 42(3): 348-351.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.020
Abstract:
Objective:To investigate the efficacy and safety of hot gutta percha vertical pressure filling technology in the treatment of C shaped root canal in mandibular second molar.Methods:Eighty-four patients with C shaped root canal lesion in mandibular second molar diagnosed by X-ray were randomly divided into the control group and observation group using numerical digit method(42 cases each group).The C shaped root canal in control group and observation group were treated with the conventional cold gutta percha lateral pressure filling technology and hot gutta percha vertical pressure filling technology,respectively.The clinical effects and incidence of complications after root canal treatment between two groups were compared.Results:The clinical efficacy in observation group was better than that in control group(P<0.01).The proper fill rate in observation group(92.86%) was higher than that in control group(71.43%)(P<0.05).The filling root time,filling material and distance between apical region in observation group were significantly better than those in control group(P<0.01).The incidence rate of complications in observation group (9.52%) was significantly lower than that in control group(33.33%)(P<0.01).Conclusions:Hot gutta percha vertical pressure filling technology for C shaped root canal in mandibular second molars can improve the toothache,gingival swelling and other symptoms,and restore the normal chewing function of teeth.The closeness in dental filling material and apical area are good,and the incidence of postoperative complications is low.
Objective:To investigate the efficacy and safety of hot gutta percha vertical pressure filling technology in the treatment of C shaped root canal in mandibular second molar.Methods:Eighty-four patients with C shaped root canal lesion in mandibular second molar diagnosed by X-ray were randomly divided into the control group and observation group using numerical digit method(42 cases each group).The C shaped root canal in control group and observation group were treated with the conventional cold gutta percha lateral pressure filling technology and hot gutta percha vertical pressure filling technology,respectively.The clinical effects and incidence of complications after root canal treatment between two groups were compared.Results:The clinical efficacy in observation group was better than that in control group(P<0.01).The proper fill rate in observation group(92.86%) was higher than that in control group(71.43%)(P<0.05).The filling root time,filling material and distance between apical region in observation group were significantly better than those in control group(P<0.01).The incidence rate of complications in observation group (9.52%) was significantly lower than that in control group(33.33%)(P<0.01).Conclusions:Hot gutta percha vertical pressure filling technology for C shaped root canal in mandibular second molars can improve the toothache,gingival swelling and other symptoms,and restore the normal chewing function of teeth.The closeness in dental filling material and apical area are good,and the incidence of postoperative complications is low.
2017, 42(3): 352-354.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.021
Abstract:
Objective:To explore curative effect of the phacoemulsification combined with real angular separation surgery to treatprimary angle closure glaucoma with cataract.Methods:Thirty patients with primary closed-angle glaucoma and cataract (46 eyes) were selected randomly.According to the operation of anterior chamber angle conglutination close range,all patients were divided into 3 groups.Of them,group A include 17 eyes with anterior chamber angle synechiae closure<180°,which received phacoemulsification and intraocular lens implantation for treatment;group B include 16 eyes with anterior chamber angle synechiae closure 180°-270°,which received phacoemulsification of step-down avoidance gettering intraocular lens implantation combined with real angle separation surgery treatment;group C include 13 eyes with anterior chamber angle synechiae closure>270°,which received phacoemulsification and intraocular lens implantation combined with real angle separation surgery treatment.The curative effects of three groups were compared.Results:After the treatment,no patient in group A needed drug intervention.One eye in group B needed drug intervention.10 eyes in group C needed drug intervention.When compared with group C,There was a significant difference in drug intervention need in group A(P<0.01)or group B(P<0.01).Conclusions:There is a best curative effect for phacoemulsification cataract intraocular lens implantation surgery in treatment of the anterior chamber angle synechiae closure <180° patients.However,for the patients with anterior chamber angle closure 180°-270°,the combination of phacoemulsification cataract intraocular lens implantation surgery and corner separation surgery will be better.No good results came for the patients with anterior chamber angle closure >270° of patients need to be treated with.
Objective:To explore curative effect of the phacoemulsification combined with real angular separation surgery to treatprimary angle closure glaucoma with cataract.Methods:Thirty patients with primary closed-angle glaucoma and cataract (46 eyes) were selected randomly.According to the operation of anterior chamber angle conglutination close range,all patients were divided into 3 groups.Of them,group A include 17 eyes with anterior chamber angle synechiae closure<180°,which received phacoemulsification and intraocular lens implantation for treatment;group B include 16 eyes with anterior chamber angle synechiae closure 180°-270°,which received phacoemulsification of step-down avoidance gettering intraocular lens implantation combined with real angle separation surgery treatment;group C include 13 eyes with anterior chamber angle synechiae closure>270°,which received phacoemulsification and intraocular lens implantation combined with real angle separation surgery treatment.The curative effects of three groups were compared.Results:After the treatment,no patient in group A needed drug intervention.One eye in group B needed drug intervention.10 eyes in group C needed drug intervention.When compared with group C,There was a significant difference in drug intervention need in group A(P<0.01)or group B(P<0.01).Conclusions:There is a best curative effect for phacoemulsification cataract intraocular lens implantation surgery in treatment of the anterior chamber angle synechiae closure <180° patients.However,for the patients with anterior chamber angle closure 180°-270°,the combination of phacoemulsification cataract intraocular lens implantation surgery and corner separation surgery will be better.No good results came for the patients with anterior chamber angle closure >270° of patients need to be treated with.
2017, 42(3): 355-358.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.022
Abstract:
Objective:To investigate the clinical effects between deanxit and doxepin in the treatment of post-stroke depression,and its effects on the neurotransmitter level.Methods:Eighty patients with post-stroke depression were randomly divided into the deanxit group and doxepin group(40 cases each group).The deanxit group and doxepin group were treated with the deanxit and doxepin for 8 weeks,respectively.The clinical effects between two groups were evaluated using the Hamilton Depression Rating Scale(HAMD),US National Institutes of Health Stroke Scale(NIHSS) and Barthel index(BI).The levels of 5-HT and DA in two groups were detected by fluorescence spectrophotometer method,and the level of NE in two groups were detected by high performance liquid chromatography(HPLC).Results:The total effective rate in deanxit group was significantly better than that in doxepin group(P<0.01).Compared before treatment,the scores of HAMD and NIHSS,and Barthel index in two groups significantly decreased and increased after treatment,respectively(P<0.01),After 2,4 and 8 weeks of treatment,the HAMD scores in deanxit group were lower than those in doxepin group(P<0.05 to P<0.01),and the Barthel index in deanxit group was higher than that in doxepin group(P<0.05 to P<0.01).The NIHSS score in deanxit group after 8 weeks of treatment was significantly lower than that in doxepin group(P<0.01).Compared before treatment,the levels of 5-HT,DA and NE in two groups significantly increased after treatment(P<0.01),and the incrasing degree of 5-HT,DA and NE levels in deanxit group were significantly higher than those in doxepin group after treatment(P<0.01).The difference of the incidence rate of adverse reaction between two groups was not statistically signficant(P>0.05).Conclusions:The treatment of post-stroke depression with deanxit is good effect and safe,which can effectively increase the neurotransmitter level,promote the nerve function recovery,improve the daily life ability of patients,and is worthy of clinical use.
Objective:To investigate the clinical effects between deanxit and doxepin in the treatment of post-stroke depression,and its effects on the neurotransmitter level.Methods:Eighty patients with post-stroke depression were randomly divided into the deanxit group and doxepin group(40 cases each group).The deanxit group and doxepin group were treated with the deanxit and doxepin for 8 weeks,respectively.The clinical effects between two groups were evaluated using the Hamilton Depression Rating Scale(HAMD),US National Institutes of Health Stroke Scale(NIHSS) and Barthel index(BI).The levels of 5-HT and DA in two groups were detected by fluorescence spectrophotometer method,and the level of NE in two groups were detected by high performance liquid chromatography(HPLC).Results:The total effective rate in deanxit group was significantly better than that in doxepin group(P<0.01).Compared before treatment,the scores of HAMD and NIHSS,and Barthel index in two groups significantly decreased and increased after treatment,respectively(P<0.01),After 2,4 and 8 weeks of treatment,the HAMD scores in deanxit group were lower than those in doxepin group(P<0.05 to P<0.01),and the Barthel index in deanxit group was higher than that in doxepin group(P<0.05 to P<0.01).The NIHSS score in deanxit group after 8 weeks of treatment was significantly lower than that in doxepin group(P<0.01).Compared before treatment,the levels of 5-HT,DA and NE in two groups significantly increased after treatment(P<0.01),and the incrasing degree of 5-HT,DA and NE levels in deanxit group were significantly higher than those in doxepin group after treatment(P<0.01).The difference of the incidence rate of adverse reaction between two groups was not statistically signficant(P>0.05).Conclusions:The treatment of post-stroke depression with deanxit is good effect and safe,which can effectively increase the neurotransmitter level,promote the nerve function recovery,improve the daily life ability of patients,and is worthy of clinical use.
2017, 42(3): 359-361.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.023
Abstract:
Objective:To investigate the effects of adefovir dipivoxil(ADV) combined with Hujuyigan capsule in the treatment of liver fibrosis in chronic hepatitis B(CHB).Methods:Sixty-five CHB patients were divided into the observation group and control group according to the number of parity.The control group were treated with ADV by oral,and the observation group were additionally treated with Hujuyigan capsule based on the control group.The ALT recovery rate,HBeAg and HBV DNA converting negative rates,hepatic fibrosis indexes and immune function in two groups were observed before and after treatment.Results:Six months after treatment,the differences of the ALT recovery rate,and HBeAg and HBV DNA converting negative rates between two groups were not statistically significant(P>0.05).Compared with the control group,the hepatic fibrosis indexes in observation group significantly decreased(P<0.01).Compared with the control group,the expression of Ⅰ γ interferon in observation group was obviously up-regulated,and the expressions of tumor necrosis factor α and interleukin-4 were inhibited(P<0.01).Conclusions:The curative efficacy of Hujuyigan capsule and ADV in treating CHB is significant,which is worthy of popularization and application.
Objective:To investigate the effects of adefovir dipivoxil(ADV) combined with Hujuyigan capsule in the treatment of liver fibrosis in chronic hepatitis B(CHB).Methods:Sixty-five CHB patients were divided into the observation group and control group according to the number of parity.The control group were treated with ADV by oral,and the observation group were additionally treated with Hujuyigan capsule based on the control group.The ALT recovery rate,HBeAg and HBV DNA converting negative rates,hepatic fibrosis indexes and immune function in two groups were observed before and after treatment.Results:Six months after treatment,the differences of the ALT recovery rate,and HBeAg and HBV DNA converting negative rates between two groups were not statistically significant(P>0.05).Compared with the control group,the hepatic fibrosis indexes in observation group significantly decreased(P<0.01).Compared with the control group,the expression of Ⅰ γ interferon in observation group was obviously up-regulated,and the expressions of tumor necrosis factor α and interleukin-4 were inhibited(P<0.01).Conclusions:The curative efficacy of Hujuyigan capsule and ADV in treating CHB is significant,which is worthy of popularization and application.
2017, 42(3): 364-367.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.025
Abstract:
Objective:To investigate the present situation of the emotion management ability in Anhui medical students,and provide the theory evidence in improving their emotion management abilities.Methods:Seven hundred seventy-nine medical students from three medical college in Anhui were selected using the method of stratified cluster sampling.The students were investigated using the "general demographic characteristics questionnaire" and "emotion management ability of medical students scale" in the way of group test.Results:The score of the emotion evaluation in girl students was better than that in the boy students(P<0.05).The differences of the scores of the emotion management,evaluation,feel,expression and regulation abilities between the only child and non-only child were not statistically significant(P>0.05).The differences of the scores of the emotion expression abilities in students with the democratic,authoritarian,indulgent and ignore parental rearing styles were statistically significant(P<0.05),and the emotion expression ability in students with the democratic parental rearing style was better than that in student with authoritarian parental rearing style(P<0.05).Emotional swing of 53.53% medical students happened during the end of the semester,96.28% medical students thought that the emotion management activity was little or no,and only 3.72% medical students thought that the emotion management activity was often.Conclusions:The emotion management abilities of medical students in different sex and parent rearing style are different,and whether it is only child or not,which is not significant difference.Emotional swing of most medical students happen during the end of the semester,and the emotion management activity is less.
Objective:To investigate the present situation of the emotion management ability in Anhui medical students,and provide the theory evidence in improving their emotion management abilities.Methods:Seven hundred seventy-nine medical students from three medical college in Anhui were selected using the method of stratified cluster sampling.The students were investigated using the "general demographic characteristics questionnaire" and "emotion management ability of medical students scale" in the way of group test.Results:The score of the emotion evaluation in girl students was better than that in the boy students(P<0.05).The differences of the scores of the emotion management,evaluation,feel,expression and regulation abilities between the only child and non-only child were not statistically significant(P>0.05).The differences of the scores of the emotion expression abilities in students with the democratic,authoritarian,indulgent and ignore parental rearing styles were statistically significant(P<0.05),and the emotion expression ability in students with the democratic parental rearing style was better than that in student with authoritarian parental rearing style(P<0.05).Emotional swing of 53.53% medical students happened during the end of the semester,96.28% medical students thought that the emotion management activity was little or no,and only 3.72% medical students thought that the emotion management activity was often.Conclusions:The emotion management abilities of medical students in different sex and parent rearing style are different,and whether it is only child or not,which is not significant difference.Emotional swing of most medical students happen during the end of the semester,and the emotion management activity is less.
2017, 42(3): 367-369,373.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.026
Abstract:
Objective:To investigate the status quo and features of learning burnout in medical students.Methods:Six hundred and thirty-three 5-year program medical students from Bengbu Medical College were investigated using the College Students Learning Burnout questionnaire.Results:The level of the learning burnout in medical students was medium,the incidence rate of which was 37.3%,and the total score of the learning burnout in boys was higher than that in girls(P<0.05).The inappropriate behavior score in the first year college students was higher than that in the second and third year college students(P<0.01).The score of low sense achievement in the fourth year college students was higher than that in other grades(P<0.05).The inappropriate behavior score in psychiatric medicine students was higher than that in clinical medicine college students(P<0.05).Conclusions:A certain degree learning burnout in medical students is found.Parents,school and student should pay attention to the problem,and take some effective measures to alleviate the learning burnout.
Objective:To investigate the status quo and features of learning burnout in medical students.Methods:Six hundred and thirty-three 5-year program medical students from Bengbu Medical College were investigated using the College Students Learning Burnout questionnaire.Results:The level of the learning burnout in medical students was medium,the incidence rate of which was 37.3%,and the total score of the learning burnout in boys was higher than that in girls(P<0.05).The inappropriate behavior score in the first year college students was higher than that in the second and third year college students(P<0.01).The score of low sense achievement in the fourth year college students was higher than that in other grades(P<0.05).The inappropriate behavior score in psychiatric medicine students was higher than that in clinical medicine college students(P<0.05).Conclusions:A certain degree learning burnout in medical students is found.Parents,school and student should pay attention to the problem,and take some effective measures to alleviate the learning burnout.
2017, 42(3): 370-373.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.027
Abstract:
Objective:To analyze the effects of the school education combined with hospital intervention on the adolescent sexual health in rural left-behind children,and explore the effective sexual health education mode in rural left-behind children.Methods:One thousand two hundred left-behind children from 4 middle schools were randomly divided into the control group and observation group(600 cases each group).The control group were taught with adolescent sexual education curriculum required by the Chinese Ministry of Education.The observation group were taught with school education combined with hospital intervention.The regular activity was implemented by school teachers and psychologists for 1 year,the content of which included sexual knowledge,value and adaptation.The scores before and after intervention between two groups were compared.Results:The differences of the scores of the basic knowledge of physiology,sexual knowledge,sexual attitude,sexual control,social adaptation and oneself adaptation before intervention between two groups were not statistically significant(P>0.05).The scores of the basic knowledge of physiology,sexual attitude and social adaptation after intervention in control group were significantly higher than those before intervention(P<0.01).The scores of all items after intervention were higher than those in observation group before intervention,and in control group after intervention(P<0.05 to P<0.01).Conclusions:Rural left-behind children belong to a special group,and their sexual knowledge is lack.The school education combined with hospital intervention can help to develop the scientific sexual concept and attitude.
Objective:To analyze the effects of the school education combined with hospital intervention on the adolescent sexual health in rural left-behind children,and explore the effective sexual health education mode in rural left-behind children.Methods:One thousand two hundred left-behind children from 4 middle schools were randomly divided into the control group and observation group(600 cases each group).The control group were taught with adolescent sexual education curriculum required by the Chinese Ministry of Education.The observation group were taught with school education combined with hospital intervention.The regular activity was implemented by school teachers and psychologists for 1 year,the content of which included sexual knowledge,value and adaptation.The scores before and after intervention between two groups were compared.Results:The differences of the scores of the basic knowledge of physiology,sexual knowledge,sexual attitude,sexual control,social adaptation and oneself adaptation before intervention between two groups were not statistically significant(P>0.05).The scores of the basic knowledge of physiology,sexual attitude and social adaptation after intervention in control group were significantly higher than those before intervention(P<0.01).The scores of all items after intervention were higher than those in observation group before intervention,and in control group after intervention(P<0.05 to P<0.01).Conclusions:Rural left-behind children belong to a special group,and their sexual knowledge is lack.The school education combined with hospital intervention can help to develop the scientific sexual concept and attitude.
2017, 42(3): 374-375,378.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.028
Abstract:
Objective:To explore the application value of the ultrasonography in early locating diagnosis of uterus cornea pregnancy and tubal interstitial pregnancy.Methods:The ultrasonographic characteristics of uterus cornea pregnancy and tubal interstitial pregnancy in 41 cases were analyzed.All patients were followed up.Results:Among 41 patients,the uterus cornea pregnancy in 27 cases and interstitial pregnancy in 14 cases were identified.Thirty-five cases were rightly diagnosed,the accuracy rate of which was 85.37%(35/41).Among 27 cases with uterus cornea pregnancy,24 cases were operated,and 3 cases were converted to intrauterine pregnancy,which included 2 cases of early abortion,and 1 case of term birth and postpartum placental retention.Fourteen cases with interstitial pregnancy were treated with laparoscopic operation.Conclusions:The ultrasonography in locating diagnosis of uterus cornea pregnancy and tubal interstitial pregnancy has high accuracy,transvaginal sonography can improve the accuracy of differential diagnosis,which play important guiding significance for the choice of clinical treatment.
Objective:To explore the application value of the ultrasonography in early locating diagnosis of uterus cornea pregnancy and tubal interstitial pregnancy.Methods:The ultrasonographic characteristics of uterus cornea pregnancy and tubal interstitial pregnancy in 41 cases were analyzed.All patients were followed up.Results:Among 41 patients,the uterus cornea pregnancy in 27 cases and interstitial pregnancy in 14 cases were identified.Thirty-five cases were rightly diagnosed,the accuracy rate of which was 85.37%(35/41).Among 27 cases with uterus cornea pregnancy,24 cases were operated,and 3 cases were converted to intrauterine pregnancy,which included 2 cases of early abortion,and 1 case of term birth and postpartum placental retention.Fourteen cases with interstitial pregnancy were treated with laparoscopic operation.Conclusions:The ultrasonography in locating diagnosis of uterus cornea pregnancy and tubal interstitial pregnancy has high accuracy,transvaginal sonography can improve the accuracy of differential diagnosis,which play important guiding significance for the choice of clinical treatment.
2017, 42(3): 376-378.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.029
Abstract:
Objective:To explore the value of high frequency color Doppler ultrasound(HCDFI) in the diagnosis of breast duct atypical hyperplasia and early breast ductal carcinoma.Methods:Ninety female patients with breast examination were detected using HCDFI,and divided into the breast duct atypical hyperplasia group(45 cases,ADH group) and early breast ductal carcinoma(45 cases,DCIS group) according to the result of pathology.Forty-five patients with general ductal hyperplasia were set as the UDH group.The image characteristics between three groups were compared.Results:With the progress of disease in UDH group,ADH group and DCIS group,the boundary regularity and clarity of lesions decreased gradually,the low echo attenuated,the high echo halo increased,and the blood flow around the lesions increased gradually(P<0.01).Conclusions:The HCDFI examination can best diagnose the breast disease,the cost of which is low,and which can be promoted as a routine examination.
Objective:To explore the value of high frequency color Doppler ultrasound(HCDFI) in the diagnosis of breast duct atypical hyperplasia and early breast ductal carcinoma.Methods:Ninety female patients with breast examination were detected using HCDFI,and divided into the breast duct atypical hyperplasia group(45 cases,ADH group) and early breast ductal carcinoma(45 cases,DCIS group) according to the result of pathology.Forty-five patients with general ductal hyperplasia were set as the UDH group.The image characteristics between three groups were compared.Results:With the progress of disease in UDH group,ADH group and DCIS group,the boundary regularity and clarity of lesions decreased gradually,the low echo attenuated,the high echo halo increased,and the blood flow around the lesions increased gradually(P<0.01).Conclusions:The HCDFI examination can best diagnose the breast disease,the cost of which is low,and which can be promoted as a routine examination.
2017, 42(3): 379-382.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.030
Abstract:
Objective:To explore the drug resistance gene of Klebsiella pneumoniae carbapenemase,and its resistant features.Methods:The drug sensitivity test and modified Hodge test in 42 strains of Klebsiella pneumoniae carbapenemase were performed,and the KPC gene of bacterium was detected using PCR.Results:The drug resistance in 42 strains of Klebsiella pneumoniae carbapenemase were severe,which was sensitive to the tigecycline,amikacin,tobramycin and cotrimoxazole.The detection results of modified Hodge test and KPC gene were positive,and the type KPC-2 gene was identified.Conclusions:KPC-2 is the major cause of drug resistance of Klebsiella pneumoniae,which should be paid attention to in clinic and laboratory.
Objective:To explore the drug resistance gene of Klebsiella pneumoniae carbapenemase,and its resistant features.Methods:The drug sensitivity test and modified Hodge test in 42 strains of Klebsiella pneumoniae carbapenemase were performed,and the KPC gene of bacterium was detected using PCR.Results:The drug resistance in 42 strains of Klebsiella pneumoniae carbapenemase were severe,which was sensitive to the tigecycline,amikacin,tobramycin and cotrimoxazole.The detection results of modified Hodge test and KPC gene were positive,and the type KPC-2 gene was identified.Conclusions:KPC-2 is the major cause of drug resistance of Klebsiella pneumoniae,which should be paid attention to in clinic and laboratory.
2017, 42(3): 382-384.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.031
Abstract:
Objective:To investigate the TORCH infection condition in early pregnant women in Huainan.Methods:The nine parameters of TORCH in 273 early pregnant women were detected using chemiluminescence(CLIA).Results:The positive rates of HSV-Ⅰ/Ⅱ IgG and TOX IgM were the highest in the nine parameters of TORCH in the early pregnancy women.There were no significant difference in the positive rates of TORCH-IgM in different ages pregnant women,and during 2014 to March 2016(P>0.05).There was significant difference in the positive rates of TORCH-IgM in different seasons(P<0.05),the positive rates of TORCH-IgM in Winter(12.50%) and Spring(14.08%) were the highest,and the positive rate of TORCH-IgM in Summer was the lowest(1.79%).Conclusions:TORCH-infection in pregnant women in Huainan can be found,which has the seasonal characteristics.It is necessary to monitor and prevent the congenital TORCH infection in Winter and Spring.
Objective:To investigate the TORCH infection condition in early pregnant women in Huainan.Methods:The nine parameters of TORCH in 273 early pregnant women were detected using chemiluminescence(CLIA).Results:The positive rates of HSV-Ⅰ/Ⅱ IgG and TOX IgM were the highest in the nine parameters of TORCH in the early pregnancy women.There were no significant difference in the positive rates of TORCH-IgM in different ages pregnant women,and during 2014 to March 2016(P>0.05).There was significant difference in the positive rates of TORCH-IgM in different seasons(P<0.05),the positive rates of TORCH-IgM in Winter(12.50%) and Spring(14.08%) were the highest,and the positive rate of TORCH-IgM in Summer was the lowest(1.79%).Conclusions:TORCH-infection in pregnant women in Huainan can be found,which has the seasonal characteristics.It is necessary to monitor and prevent the congenital TORCH infection in Winter and Spring.
2017, 42(3): 385-387.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.032
Abstract:
Objective:To evaluate the effects of the review tool intervention on the reasonable medication in community senile patients with chronic diseases based on Beers standard.Methods:Two hundred community senile patients with chronic diseases were randomly selected,and divided into the control group(103 cases) and intervention group(97 cases).The control group were instructed with routine medication,and the intervention group were instructed with the review tool intervention of the reasonable medication based on the Beers standard.The medication between two groups was compared.Results:The differences of the benefit of medication and indicators of life quality before intervention between two groups were not statistically significant(P>0.05).After intervention,the adverse reactions,amount and cost of medication in intervention group were significantly less than those in control group(P<0.01),but the compliance of medication in intervention group was significantly better than that in control group(P<0.01).The difference of the super indications medication between two groups was not statistically significant(P>0.05).The indicators of life quality in intervention group was better than that in control group(P<0.05 to P<0.01).Conclusions:The review tool intervention of the reasonable medication in community senile patients with chronic diseases based on Beers standard is safe and effective,which can lighten the financial burden and improve the quality of life and health of patients,and is worth popularizing.
Objective:To evaluate the effects of the review tool intervention on the reasonable medication in community senile patients with chronic diseases based on Beers standard.Methods:Two hundred community senile patients with chronic diseases were randomly selected,and divided into the control group(103 cases) and intervention group(97 cases).The control group were instructed with routine medication,and the intervention group were instructed with the review tool intervention of the reasonable medication based on the Beers standard.The medication between two groups was compared.Results:The differences of the benefit of medication and indicators of life quality before intervention between two groups were not statistically significant(P>0.05).After intervention,the adverse reactions,amount and cost of medication in intervention group were significantly less than those in control group(P<0.01),but the compliance of medication in intervention group was significantly better than that in control group(P<0.01).The difference of the super indications medication between two groups was not statistically significant(P>0.05).The indicators of life quality in intervention group was better than that in control group(P<0.05 to P<0.01).Conclusions:The review tool intervention of the reasonable medication in community senile patients with chronic diseases based on Beers standard is safe and effective,which can lighten the financial burden and improve the quality of life and health of patients,and is worth popularizing.
2017, 42(3): 388-391.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.033
Abstract:
Objective:To evaluate the application effects of the group cooperation combined with bedside teaching mode in the practice teaching of medical nursing.Methods:One hundred and eighteen nursing students in Grade 2011 from the third teaching class and sixth teaching class were in Bengbu Medical Gollege divided into the control group(58 students) and observation group(60 students),respectively.The control group were taught with traditional practice teaching method,and the observation group were taught with the group cooperation combined with bedside teaching.The scores of teaching exam results,questionnaire survey and critical thinking between two groups were compared.Results:The exam score in observation group was higher than that in control group(P<0.05 to P<0.01).The acceptance of the group cooperation combined with bedside teaching mode in observation group was 93%.Among 7 characteristics,the differences of the open-mindedness,analysis capability and self-confidence between two groups were statistically significant(P<0.05 to P<0.01).Conclusions:The group cooperation combined with bedside teaching mode can effectively improve the teaching effects and critical thinking ability of students.
Objective:To evaluate the application effects of the group cooperation combined with bedside teaching mode in the practice teaching of medical nursing.Methods:One hundred and eighteen nursing students in Grade 2011 from the third teaching class and sixth teaching class were in Bengbu Medical Gollege divided into the control group(58 students) and observation group(60 students),respectively.The control group were taught with traditional practice teaching method,and the observation group were taught with the group cooperation combined with bedside teaching.The scores of teaching exam results,questionnaire survey and critical thinking between two groups were compared.Results:The exam score in observation group was higher than that in control group(P<0.05 to P<0.01).The acceptance of the group cooperation combined with bedside teaching mode in observation group was 93%.Among 7 characteristics,the differences of the open-mindedness,analysis capability and self-confidence between two groups were statistically significant(P<0.05 to P<0.01).Conclusions:The group cooperation combined with bedside teaching mode can effectively improve the teaching effects and critical thinking ability of students.
2017, 42(3): 392-394,398.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.034
Abstract:
Objective:To investigate the effects of the situation simulation teaching of emergency nursing skills for further improving the comprehensive competence of first-aid knowledge and skills of students.Methods:Using the cluster sampling,138 students from nurse department grade 2013 and 142 students from dental and obstetric department grade 2013 were divided into the observation group and control group,respectively.The observation group and control group were trained using the traditional demonstration and situation simulation,respectively.After finishing practice,the comprehensive effect of situation simulation teaching was investigated using questionnaire,and the course achievement was analyzed.Results:The scores of the single manipulation skill,first-aid comprehensive skill and theory in observation group were higher than those in control group(P<0.01).The evaluation of student on the situation simulation teaching was better.Among 12 items,no student selected the "no-help" and "uncertainty" items,and 93.5% to 100% students selected "great help" item.Some factors influencing situation simulation teaching were found by qualitative interview and student reflection.Conclusions:The situation simulation practice can help to improve the emergency nursing abilities of students.
Objective:To investigate the effects of the situation simulation teaching of emergency nursing skills for further improving the comprehensive competence of first-aid knowledge and skills of students.Methods:Using the cluster sampling,138 students from nurse department grade 2013 and 142 students from dental and obstetric department grade 2013 were divided into the observation group and control group,respectively.The observation group and control group were trained using the traditional demonstration and situation simulation,respectively.After finishing practice,the comprehensive effect of situation simulation teaching was investigated using questionnaire,and the course achievement was analyzed.Results:The scores of the single manipulation skill,first-aid comprehensive skill and theory in observation group were higher than those in control group(P<0.01).The evaluation of student on the situation simulation teaching was better.Among 12 items,no student selected the "no-help" and "uncertainty" items,and 93.5% to 100% students selected "great help" item.Some factors influencing situation simulation teaching were found by qualitative interview and student reflection.Conclusions:The situation simulation practice can help to improve the emergency nursing abilities of students.
2017, 42(3): 395-398.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.035
Abstract:
Objective:To explore the construction and practice effects of the diversified evaluation system in oral and maxillofacial surgery curriculum.Methods:A total of 62 undergraduates in grade 2014 and 61 undergraduates in grade 2013 in Department of Stomatology from Bengbu Medical College were divided into the experimental group and control group,respectively.The experimental group and control group were evaluated using the diversified assessment evaluation system and traditional examination evaluation system,respectively.The examination scores and feedback from students by self-designed questionnaire were analyzed,and the implement effect between two evaluating model was compared.Results:The scores of final theory test,experiment skill test and total course in experimental group were significantly higher than those in control group(P<0.01).The results of questionnaire showed that the students with "positive" opinion accounted for 88.7% to 95.2%,which was higher than that in the students with "indifferent" and "negative" opinion.Conclusions:The application of the diversified assessment evaluation system can improve the academic performance and overall quality of the undergraduates,which can play an important role in cultivating the oral and maxillofacial surgery talents with strong solid foundation of theory and clinical ability,high innovative spirit and practical competence.
Objective:To explore the construction and practice effects of the diversified evaluation system in oral and maxillofacial surgery curriculum.Methods:A total of 62 undergraduates in grade 2014 and 61 undergraduates in grade 2013 in Department of Stomatology from Bengbu Medical College were divided into the experimental group and control group,respectively.The experimental group and control group were evaluated using the diversified assessment evaluation system and traditional examination evaluation system,respectively.The examination scores and feedback from students by self-designed questionnaire were analyzed,and the implement effect between two evaluating model was compared.Results:The scores of final theory test,experiment skill test and total course in experimental group were significantly higher than those in control group(P<0.01).The results of questionnaire showed that the students with "positive" opinion accounted for 88.7% to 95.2%,which was higher than that in the students with "indifferent" and "negative" opinion.Conclusions:The application of the diversified assessment evaluation system can improve the academic performance and overall quality of the undergraduates,which can play an important role in cultivating the oral and maxillofacial surgery talents with strong solid foundation of theory and clinical ability,high innovative spirit and practical competence.
2017, 42(3): 399-401.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.036
Abstract:
Objective:To investigate the incidence of nosocomial infection in ICU.Methods:The incidence of the nosocomial infection in ICU was investigated using the targeted monitoring method from 2014 to 2015.Results:Eight hundred and fifty-seven patients were monitored.The nosocomial infection in 48 cases were found.The case infection rate,adjustment infection rate and adjustment day infection rate were 5.6%,1.55% and 10.32‰,respectively.The ventilator-associated pneumonia day infection rate,indwelling catheter-associated urinary tract day infection rate and central venous cannula-associated blood flow day infection rate were 16.54‰,1.27‰ and 1.15‰,respectively.Conclusions:The incidence of nosocomial infection in ICU is high,which mainly comes from three kinds of invasive operations.The targeted monitoring can timely obtain the dynamic information of nosocomial infection,and making specific intervention measures can reduce the incidence of hospital infection.
Objective:To investigate the incidence of nosocomial infection in ICU.Methods:The incidence of the nosocomial infection in ICU was investigated using the targeted monitoring method from 2014 to 2015.Results:Eight hundred and fifty-seven patients were monitored.The nosocomial infection in 48 cases were found.The case infection rate,adjustment infection rate and adjustment day infection rate were 5.6%,1.55% and 10.32‰,respectively.The ventilator-associated pneumonia day infection rate,indwelling catheter-associated urinary tract day infection rate and central venous cannula-associated blood flow day infection rate were 16.54‰,1.27‰ and 1.15‰,respectively.Conclusions:The incidence of nosocomial infection in ICU is high,which mainly comes from three kinds of invasive operations.The targeted monitoring can timely obtain the dynamic information of nosocomial infection,and making specific intervention measures can reduce the incidence of hospital infection.
2017, 42(3): 402-404.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.037
Abstract:
Objective:To explore the effects of the family-centered care guidance on the enterostomy children and their patient.Methods:The data of 52 children treated with enterostomy and their parent were collected using the method of convenient sampling from January 2014 to May 2015,and the parent were intervened with the family-centered care mode.The psychological condition and disease awareness of parents were evaluated before and after intervention.Results:During the intervention,5 cases with skin dermatitis around stoma were found,and which was improved after care guidance.The scores of anxiety and depression of parent after intervention were significantly lower than those before intervention(P<0.01).The awareness of pediatric colostomy nursing knowledge in parent after intervention was significantly higher than those before intervention(P<0.01).Conclusions:The family-centered care mode can effectively alleviate the psychological burden of parent,significantly improve the ability of taking care of infants with stoma of parent,and reduce the postoperative complications.
Objective:To explore the effects of the family-centered care guidance on the enterostomy children and their patient.Methods:The data of 52 children treated with enterostomy and their parent were collected using the method of convenient sampling from January 2014 to May 2015,and the parent were intervened with the family-centered care mode.The psychological condition and disease awareness of parents were evaluated before and after intervention.Results:During the intervention,5 cases with skin dermatitis around stoma were found,and which was improved after care guidance.The scores of anxiety and depression of parent after intervention were significantly lower than those before intervention(P<0.01).The awareness of pediatric colostomy nursing knowledge in parent after intervention was significantly higher than those before intervention(P<0.01).Conclusions:The family-centered care mode can effectively alleviate the psychological burden of parent,significantly improve the ability of taking care of infants with stoma of parent,and reduce the postoperative complications.
2017, 42(3): 405-408.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.038
Abstract:
Objective:To analyze the medication compliance in elderly patients with benign prostatic hyperplasia(BPH),and influence factors of compliance.Methods:The medication compliance in elderly patients with BPH was investigated using the cross-sectional study method.The influence factor of medication compliance was analyzed using logistic regression analysis.Results:Among 406 elderly patients with BPH,only 47.3% patients were with good medication compliace.Multivariate logistic regression analysis showed that the age,education level,marital status,IPSS score,drug type and comorbidity were the influence factors of the medication compliance (P<0.05 to P<0.01).Conclusions:The medication compliance of patients with BPH is poor,and the education level,marital status,IPSS score and drug type are the influence factors of medication compliance.Developing the health education and strengthening the psychological care of patients,and establishing the following up system of medication compliance can improve the medication compliance.
Objective:To analyze the medication compliance in elderly patients with benign prostatic hyperplasia(BPH),and influence factors of compliance.Methods:The medication compliance in elderly patients with BPH was investigated using the cross-sectional study method.The influence factor of medication compliance was analyzed using logistic regression analysis.Results:Among 406 elderly patients with BPH,only 47.3% patients were with good medication compliace.Multivariate logistic regression analysis showed that the age,education level,marital status,IPSS score,drug type and comorbidity were the influence factors of the medication compliance (P<0.05 to P<0.01).Conclusions:The medication compliance of patients with BPH is poor,and the education level,marital status,IPSS score and drug type are the influence factors of medication compliance.Developing the health education and strengthening the psychological care of patients,and establishing the following up system of medication compliance can improve the medication compliance.
2017, 42(3): 408-410.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.039
Abstract:
Objective:To investigate the intervention effects of the continuously humanistic care on patients in Intensive Care Unit(ICU).Methods:Ninety-six critical patients in ICU were randomly divided into the observation group and control group according to the admission time(48 cases each group).The control group and observation group were nursed with the routine ICU care and routine ICU care combined with continuously humanistic care,respectively.The nursing satisfaction and selfrating anxiety scale(SAS) score before and after unrsing between two groups were compared.Results:The difference of the SAS score before nursing between two groups was not statistically significant(P>0.05),and the difference of the SAS score between before and after nuring in control group was not statistically significant(P>0.05).Compared before nursing,the SAS score in the observation group significantly decreased after unursing,and which was also lower than that in control group after nursing(P<0.01).The satisfaction in the observation group was significantly higher than that in control group(P<0.01).Conclusions:The routine ICU care combined with continuously humanistic care can improve the status of anxiety and satisfaction of patients,and promote the harmony between nurses and patients,which is worthy of application in clinic.
Objective:To investigate the intervention effects of the continuously humanistic care on patients in Intensive Care Unit(ICU).Methods:Ninety-six critical patients in ICU were randomly divided into the observation group and control group according to the admission time(48 cases each group).The control group and observation group were nursed with the routine ICU care and routine ICU care combined with continuously humanistic care,respectively.The nursing satisfaction and selfrating anxiety scale(SAS) score before and after unrsing between two groups were compared.Results:The difference of the SAS score before nursing between two groups was not statistically significant(P>0.05),and the difference of the SAS score between before and after nuring in control group was not statistically significant(P>0.05).Compared before nursing,the SAS score in the observation group significantly decreased after unursing,and which was also lower than that in control group after nursing(P<0.01).The satisfaction in the observation group was significantly higher than that in control group(P<0.01).Conclusions:The routine ICU care combined with continuously humanistic care can improve the status of anxiety and satisfaction of patients,and promote the harmony between nurses and patients,which is worthy of application in clinic.
2017, 42(3): 411-414.
doi: 10.13898/j.cnki.issn.1000-2200.2017.03.040
Abstract:
Objective:To explore the effects of the holistic nursing of responsibility group in operation room on the nursing effect,satisfaction and prognosis of patients.Methods:The clinical data of 110 patients treated with operation were retrospectively analyzed.The patients were divided into the control group(49 cases) and observation group(61 cases) according to the nursing plan.The control group were nursed with routine means,and the observation group were nursed with holistic nursing means guided by responsibility group.The nursing effect between two groups were compared.Results:The scores of nursing quality indicators in observation group were significantly higher than those in control group(P<0.01),and the difference of the incidence rate of common complications between two groups was not statistically significant(P>0.05).The nursing satisfaction degree and prognosis excellent rate in control group(69.39% and 67.35%) were lower than those in observation group(96.72% and 91.80%),respectively(P<0.01 and P<0.05).Compared with before nursing,the scores of psychological status and life quality in two groups were significantly improved after nursing,but the improvement degree of which in observation group was significantly better than that in control group(P<0.01).Conclusions:The holistic nursing of responsibility group in operation room has positive effect on the nursing effect,satisfaction degree and prognosis,which can relieve the negative mood and improve the life quality of patients.
Objective:To explore the effects of the holistic nursing of responsibility group in operation room on the nursing effect,satisfaction and prognosis of patients.Methods:The clinical data of 110 patients treated with operation were retrospectively analyzed.The patients were divided into the control group(49 cases) and observation group(61 cases) according to the nursing plan.The control group were nursed with routine means,and the observation group were nursed with holistic nursing means guided by responsibility group.The nursing effect between two groups were compared.Results:The scores of nursing quality indicators in observation group were significantly higher than those in control group(P<0.01),and the difference of the incidence rate of common complications between two groups was not statistically significant(P>0.05).The nursing satisfaction degree and prognosis excellent rate in control group(69.39% and 67.35%) were lower than those in observation group(96.72% and 91.80%),respectively(P<0.01 and P<0.05).Compared with before nursing,the scores of psychological status and life quality in two groups were significantly improved after nursing,but the improvement degree of which in observation group was significantly better than that in control group(P<0.01).Conclusions:The holistic nursing of responsibility group in operation room has positive effect on the nursing effect,satisfaction degree and prognosis,which can relieve the negative mood and improve the life quality of patients.
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