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2017 Vol. 42, No. 4
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2017, 42(4): 421-424.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.001
Abstract:
Objective:To construct the recombinant plasmid vector of pcDNA3.1-RPS27a,and investigate the localization and expression of RPS27a protein in HepG2 and SMMC7721 cell lines.Methods:The RPS27a gene was synthesed and cloned into the pcDNA3.1 vector.After the pcDNA3.1 plasmid was transfected into E.coli DH5α,and the positive plasmid was extracted and sequenced.The reconstructed pcDNA3.1-RPS27a plasmid was transfected into the HepG2 and SMMC7721 cell lines.The expression and localization of RPS27a in eukaryotic cells were detected by laser confocal microscopy.Results:The recombinant plasmid pcDNA3.1-RPS27a was successfully constructed.The laser confocal microscopy showed that the RPS27a mainly expressed in the cytoplasm of HepG2 and SMMC7721 cell lines.Conclusions:The recombinant plasmid pcDNA3.1-RPS27a is successfully constructed,and the RPS27a protein mainly expresses in the cytoplasm of HepG2 and SMMC7721 cell lines.
Objective:To construct the recombinant plasmid vector of pcDNA3.1-RPS27a,and investigate the localization and expression of RPS27a protein in HepG2 and SMMC7721 cell lines.Methods:The RPS27a gene was synthesed and cloned into the pcDNA3.1 vector.After the pcDNA3.1 plasmid was transfected into E.coli DH5α,and the positive plasmid was extracted and sequenced.The reconstructed pcDNA3.1-RPS27a plasmid was transfected into the HepG2 and SMMC7721 cell lines.The expression and localization of RPS27a in eukaryotic cells were detected by laser confocal microscopy.Results:The recombinant plasmid pcDNA3.1-RPS27a was successfully constructed.The laser confocal microscopy showed that the RPS27a mainly expressed in the cytoplasm of HepG2 and SMMC7721 cell lines.Conclusions:The recombinant plasmid pcDNA3.1-RPS27a is successfully constructed,and the RPS27a protein mainly expresses in the cytoplasm of HepG2 and SMMC7721 cell lines.
2017, 42(4): 424-426.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.002
Abstract:
Objective:To investigate the expression of amplified in breast cancer 1(AIB1) protein in esophageal squamous cell carcinoma,and its clinical significance.Methods:The expressions of AIB1 in esophageal squamous cell carcinoma tissue(60 samples) and normal esophageal mucosa tissue(30 samples) were detected using immunohistochemical technique,and the correlation between the AIB1 expression and clinicopathology was analyzed.Results:The positive rate of AIB1 in esophageal squamous cell carcinoma tissue was 53.3%,the AIB1 protein expression in normal esophageal mucosa was negative or weak positive,and the difference of the AIB1 expression between two kinds of tissues was statistically significant(P<0.01).The differences of the AIB1 expression in different differentiation,lymph node metastasis and clinical stages tumors were statistically significant(P<0.05 to P<0.01).The differences of the AIB1 expression in different ages and sexuality patients,and invasive depth tumor were not statistically significant(P>0.05).Conclusions:Abnormal high expression of AIB1 protein in esophageal squamous cell carcinoma may affect the occurrence,development,invasion and metastasis process of tumor.
Objective:To investigate the expression of amplified in breast cancer 1(AIB1) protein in esophageal squamous cell carcinoma,and its clinical significance.Methods:The expressions of AIB1 in esophageal squamous cell carcinoma tissue(60 samples) and normal esophageal mucosa tissue(30 samples) were detected using immunohistochemical technique,and the correlation between the AIB1 expression and clinicopathology was analyzed.Results:The positive rate of AIB1 in esophageal squamous cell carcinoma tissue was 53.3%,the AIB1 protein expression in normal esophageal mucosa was negative or weak positive,and the difference of the AIB1 expression between two kinds of tissues was statistically significant(P<0.01).The differences of the AIB1 expression in different differentiation,lymph node metastasis and clinical stages tumors were statistically significant(P<0.05 to P<0.01).The differences of the AIB1 expression in different ages and sexuality patients,and invasive depth tumor were not statistically significant(P>0.05).Conclusions:Abnormal high expression of AIB1 protein in esophageal squamous cell carcinoma may affect the occurrence,development,invasion and metastasis process of tumor.
2017, 42(4): 427-430,446.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.003
Abstract:
Objective:To investigate the effects of Roux-en-Y gastric bypass(RYGB) surgery on the inflammation and lipid accumulation of brain tissue in obese rats induced by high fat diet.Methods:Thirty Wistar rats were randomly divided into the normal diet group(ND group),high-fat diet group(HFD group) and high-fat diet plus RYGB group(HFD plus RYGB group)(10 rats each group).The ND group was treated with the normal diet,and the HFD group and HFD plus RYGB group were treated with high-fat diet.After 16 weeks,the ND group and HFD group were treated with sham operation,and the HFD plus RYGB group was treated with RYGB.After operation,the ND group was continuously treated with the normal diet,and the HFD group and HFD plus RYGB group were continuously treated with high-fat diet.Rats were sacrificed after 4 weeks of operation.The levels of serum triglyceride(TG),total cholesterol(TC) and free fatty acid(FFA) in three groups were detected using ELISA.The levels of diacylglycerol(DAG),FFA,TNF-α,IL-1 and IL-6 in brain tissue of three groups were measured using ELISA.The expressions of Iba-1 and glial fibrillary acidic protein(GFAP) in hypothalamus brain tissue were observed by immunohistochemistry.The neuronal morphology in hypothalamus brain was observed using electron microscope.Results:The levels of serum TG,TC and FFA in HFD group were higher than those in ND group and HFD plus RYGB group(P<0.05 to P<0.01).The level of FFA in HFD plus RYGB group was significantly higher than that in ND group(P<0.01),and the differences of the levels of TG and TC between HFD plus RYGB group and HFD group were not statistically significant(P>0.05).The levels of DAG and FFA in brain tissue of HFD group were significantly higher than those in HFD plus RYGB group and ND group(P<0.01),and the levels of DAG and FFA in brain tissue of HFD plus RYGB group were significantly higher than those in ND group(P<0.01).The levels of TNF-α,IL-1 and IL-6 in brain tissue of ND group and HFD plus RYGB group were significantly lower than those in HFD group(P<0.01).The level of TNF-α in brain tissue of HFD plus RYGB group was significantly higher than that in ND group(P<0.01),but the differences of the levels of IL-1 and IL-6 between HFD plus RYGB group and ND group were not statistically significant(P>0.05).The immunohistochemistry results showed that the number of the Iba-1 and GFAP positive cells increased,cell body enlarged and protuberance thickened and lengthened in hypothalamus of HFD group and HFD plus RYGB group.Compared with the HFD group,the number of Iba-1 and GFAP positive cells in hypothalamus of HFD plus RYGB group decreased.The neuronal mitochondrial edema,vacuole and a large number of autophagosomes were found in HFD group,and the neuronopathy alleviated in hypothalamus under electron microscope.Conclusions:RYGB can down-regulate the expressions of TNF-α,IL-1 and IL-6,alleviate the neuron lesion,improve the inflammatory response and reduce lipid accumulation in hypothalamus tissue of the obese rats induced by high fat diet.
Objective:To investigate the effects of Roux-en-Y gastric bypass(RYGB) surgery on the inflammation and lipid accumulation of brain tissue in obese rats induced by high fat diet.Methods:Thirty Wistar rats were randomly divided into the normal diet group(ND group),high-fat diet group(HFD group) and high-fat diet plus RYGB group(HFD plus RYGB group)(10 rats each group).The ND group was treated with the normal diet,and the HFD group and HFD plus RYGB group were treated with high-fat diet.After 16 weeks,the ND group and HFD group were treated with sham operation,and the HFD plus RYGB group was treated with RYGB.After operation,the ND group was continuously treated with the normal diet,and the HFD group and HFD plus RYGB group were continuously treated with high-fat diet.Rats were sacrificed after 4 weeks of operation.The levels of serum triglyceride(TG),total cholesterol(TC) and free fatty acid(FFA) in three groups were detected using ELISA.The levels of diacylglycerol(DAG),FFA,TNF-α,IL-1 and IL-6 in brain tissue of three groups were measured using ELISA.The expressions of Iba-1 and glial fibrillary acidic protein(GFAP) in hypothalamus brain tissue were observed by immunohistochemistry.The neuronal morphology in hypothalamus brain was observed using electron microscope.Results:The levels of serum TG,TC and FFA in HFD group were higher than those in ND group and HFD plus RYGB group(P<0.05 to P<0.01).The level of FFA in HFD plus RYGB group was significantly higher than that in ND group(P<0.01),and the differences of the levels of TG and TC between HFD plus RYGB group and HFD group were not statistically significant(P>0.05).The levels of DAG and FFA in brain tissue of HFD group were significantly higher than those in HFD plus RYGB group and ND group(P<0.01),and the levels of DAG and FFA in brain tissue of HFD plus RYGB group were significantly higher than those in ND group(P<0.01).The levels of TNF-α,IL-1 and IL-6 in brain tissue of ND group and HFD plus RYGB group were significantly lower than those in HFD group(P<0.01).The level of TNF-α in brain tissue of HFD plus RYGB group was significantly higher than that in ND group(P<0.01),but the differences of the levels of IL-1 and IL-6 between HFD plus RYGB group and ND group were not statistically significant(P>0.05).The immunohistochemistry results showed that the number of the Iba-1 and GFAP positive cells increased,cell body enlarged and protuberance thickened and lengthened in hypothalamus of HFD group and HFD plus RYGB group.Compared with the HFD group,the number of Iba-1 and GFAP positive cells in hypothalamus of HFD plus RYGB group decreased.The neuronal mitochondrial edema,vacuole and a large number of autophagosomes were found in HFD group,and the neuronopathy alleviated in hypothalamus under electron microscope.Conclusions:RYGB can down-regulate the expressions of TNF-α,IL-1 and IL-6,alleviate the neuron lesion,improve the inflammatory response and reduce lipid accumulation in hypothalamus tissue of the obese rats induced by high fat diet.
2017, 42(4): 431-433.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.004
Abstract:
Objective:To evaluate the efficacy and safety of the early treatment of severe mycoplasma pneumoniae pneumonia(MPP) with glucocorticoid in children.Methods:Forty-one severe MPP children were divided into the early glucocorticoid treatment group(22 cases) and late glucocorticoid treatment group(19 cases),and treated with azithromycin combined with conventional method.The early treatment glucocorticoid group was additionally treated with 0.2 to 0.5 mg·kg-1·d-1 of dexamethasone everyday by intravenous drip within 24 h of admission for 7 to 10 days.The duration of lowering temperature and hospitalization,and other index between two groups were compared.Results:The duration of fever and hospitalization in early glucocorticoid treatment group were significantly shorter than those in late glucocorticoid treatment group(P<0.01 to P<0.05).The levels of serum CRP in two groups were significantly improved after treatment,and the improvement degree of which in early glucocorticoid treatment group was more obvious than in late glucocorticoid treatment group(P<0.01).The differences of the incidence rates of chest X-ray improvement,treatment failure and extrapulmonary organ involvement between two groups were not statistically significant(P>0.05).Conclusions:The application of glucocorticoid within 24 h of admission can significantly shorten the duration of fever and hospitalization in child with severe MPP.
Objective:To evaluate the efficacy and safety of the early treatment of severe mycoplasma pneumoniae pneumonia(MPP) with glucocorticoid in children.Methods:Forty-one severe MPP children were divided into the early glucocorticoid treatment group(22 cases) and late glucocorticoid treatment group(19 cases),and treated with azithromycin combined with conventional method.The early treatment glucocorticoid group was additionally treated with 0.2 to 0.5 mg·kg-1·d-1 of dexamethasone everyday by intravenous drip within 24 h of admission for 7 to 10 days.The duration of lowering temperature and hospitalization,and other index between two groups were compared.Results:The duration of fever and hospitalization in early glucocorticoid treatment group were significantly shorter than those in late glucocorticoid treatment group(P<0.01 to P<0.05).The levels of serum CRP in two groups were significantly improved after treatment,and the improvement degree of which in early glucocorticoid treatment group was more obvious than in late glucocorticoid treatment group(P<0.01).The differences of the incidence rates of chest X-ray improvement,treatment failure and extrapulmonary organ involvement between two groups were not statistically significant(P>0.05).Conclusions:The application of glucocorticoid within 24 h of admission can significantly shorten the duration of fever and hospitalization in child with severe MPP.
2017, 42(4): 434-436.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.005
Abstract:
Objective:To investigate the clinical efficacy of Tongfu Huatan Decoction combined with western medicine in the treatment of chronic obstructive pulmonary disease in acute exacerbation(AECOPD).Methods:Eighty patients with AECOPD were divided into the control group and observation group using random number table method(40 cases each group).The control group and observation group were treated with routine western medicine and Tongfu Huatan Decoction combined with routine western medicine for two weeks(1 course),respectively.The clinical efficacy,lung function,6 min walking test results and changes of inflammatory markers between two groups were compared.Results:The total effective rate in observation group(95.0%) was higher than that in control group(72.5%)(P<0.05).After treatment,the lung function indictors in observation group were higher than those in control group(P<0.01),the 6 min walk distance in observation group(325.4±24.2)m was longer than that in control group(277.6±21.5)m(P<0.01).After treatment,the level of superoxide dismutase in peripheral blood in observation group was higher than that in control group,and the levels of lipid peroxide,white blood count and C-reactive protein in observation group were lower than those in control group(P<0.05 to P<0.01).Conclusions:Tongfu Huatan Decoction can improve the therapeutic effects of western medicine on AECOPD,which is worthy of promotion.
Objective:To investigate the clinical efficacy of Tongfu Huatan Decoction combined with western medicine in the treatment of chronic obstructive pulmonary disease in acute exacerbation(AECOPD).Methods:Eighty patients with AECOPD were divided into the control group and observation group using random number table method(40 cases each group).The control group and observation group were treated with routine western medicine and Tongfu Huatan Decoction combined with routine western medicine for two weeks(1 course),respectively.The clinical efficacy,lung function,6 min walking test results and changes of inflammatory markers between two groups were compared.Results:The total effective rate in observation group(95.0%) was higher than that in control group(72.5%)(P<0.05).After treatment,the lung function indictors in observation group were higher than those in control group(P<0.01),the 6 min walk distance in observation group(325.4±24.2)m was longer than that in control group(277.6±21.5)m(P<0.01).After treatment,the level of superoxide dismutase in peripheral blood in observation group was higher than that in control group,and the levels of lipid peroxide,white blood count and C-reactive protein in observation group were lower than those in control group(P<0.05 to P<0.01).Conclusions:Tongfu Huatan Decoction can improve the therapeutic effects of western medicine on AECOPD,which is worthy of promotion.
2017, 42(4): 437-440.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.006
Abstract:
Objective:To investigate the clinical application of the modified thoracodorsal artery perforator flap with partial muscle around vascular pedicle.Methods:Eleven cases treated with modified thoracodorsal artery perforator flaps were applied.The distribution and location of the main perforator vessels of thoracodorsal artery lateral branches were explored using Doppler flowmetry before operation.The perforator vessels with 3 to 5cm muscle in width were separated,and the modified flap with most partial latissimus dorsi muscle and thoracodorsal nerve was designed.The donor area was repaired with skin-grafting or direct suturing.The near transferring of ipsilateral vascular pedicle in 4 cases and free grafting in 11 cases were applied.Results:One case necrosed after vascular crisis,and other 10 cases survived.The largest and smallest area of the flaps were 22 cm×15 cm and 8 cm×5 cm,respectively.During the following up of 6 to 24 months,the blood supply and texture of flaps were fine.Except the repairing of the foot wound was slightly overstaffed,other appearances were good.The donor site was hidden,and has obvious scars.The dysfunction of latissimus dorsi was not found.Conclusions:The perforator vessel of thoracodorsal artery can be located by Doppler flowmetry before operation.The anatomical position of the perforator vessel of thoracodorsal artery is relatively constant,the cutting of modified flap with partial muscle around perforator is convenient,and the survival rate of which is high.
Objective:To investigate the clinical application of the modified thoracodorsal artery perforator flap with partial muscle around vascular pedicle.Methods:Eleven cases treated with modified thoracodorsal artery perforator flaps were applied.The distribution and location of the main perforator vessels of thoracodorsal artery lateral branches were explored using Doppler flowmetry before operation.The perforator vessels with 3 to 5cm muscle in width were separated,and the modified flap with most partial latissimus dorsi muscle and thoracodorsal nerve was designed.The donor area was repaired with skin-grafting or direct suturing.The near transferring of ipsilateral vascular pedicle in 4 cases and free grafting in 11 cases were applied.Results:One case necrosed after vascular crisis,and other 10 cases survived.The largest and smallest area of the flaps were 22 cm×15 cm and 8 cm×5 cm,respectively.During the following up of 6 to 24 months,the blood supply and texture of flaps were fine.Except the repairing of the foot wound was slightly overstaffed,other appearances were good.The donor site was hidden,and has obvious scars.The dysfunction of latissimus dorsi was not found.Conclusions:The perforator vessel of thoracodorsal artery can be located by Doppler flowmetry before operation.The anatomical position of the perforator vessel of thoracodorsal artery is relatively constant,the cutting of modified flap with partial muscle around perforator is convenient,and the survival rate of which is high.
2017, 42(4): 440-442.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.007
Abstract:
Objective:To compare the clinical efficacy between arthroscopic treatment and conservative treatment in early osteoarthritis(OA) of knee joint.Methods:The clinical data of 189 patients with OA of knee joint were retrospectively analyzed.Eighty-four patients were treated with arthroscopy,and 105 cases were treated with conservative method.The duration of symptom,preoperative knee standing radiograph of Kellgren-Lawrence(K-L) grade,articular interlocking symptom,fixed pain point and score of the anterior Lysholm before and after treatment between two groups were compared.Results:After treatment,the Lysholm scores were significantly higher than those of before treatment in two groups(P<0.01),and the difference of the increasing degree of the Lysholm score after treatment between two groups was statistically significant(P<0.01).Conclusions:Both the clinical effects of arthroscopic treatment and conservative treatment in early OA of knee joint are good.
Objective:To compare the clinical efficacy between arthroscopic treatment and conservative treatment in early osteoarthritis(OA) of knee joint.Methods:The clinical data of 189 patients with OA of knee joint were retrospectively analyzed.Eighty-four patients were treated with arthroscopy,and 105 cases were treated with conservative method.The duration of symptom,preoperative knee standing radiograph of Kellgren-Lawrence(K-L) grade,articular interlocking symptom,fixed pain point and score of the anterior Lysholm before and after treatment between two groups were compared.Results:After treatment,the Lysholm scores were significantly higher than those of before treatment in two groups(P<0.01),and the difference of the increasing degree of the Lysholm score after treatment between two groups was statistically significant(P<0.01).Conclusions:Both the clinical effects of arthroscopic treatment and conservative treatment in early OA of knee joint are good.
2017, 42(4): 443-446.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.008
Abstract:
Objective:To investigate the curative effects of the Shenyi Capsule in the treatment of locally advanced cervical cancer.Methods:One hundred and seven patients with locally advanced cervical cancer were randomly divided into the observation group(54 cases) and control group(53 cases).The control group was treated with the concurrent chemoradiotherapy,and the observation group was treated with Shenyi Capsule combined with concurrent chemoradiotherapy until the disease progression.The short and long-term curative effects between two groups were compared.Results:After treatment,the 2-year survival rate in observation group was significantly higher than that in control group(P<0.05);and the distant metastasis rate in observation group was significantly lower than that in control group(P<0.05).The differences of the short-term effective and incidence rate of adverse reactions between two groups were not statistically significant(P>0.05).Conclusions:Shenyi Capsule combined with chemoradiotherapy in the treatment of locally advanced cervical cancer has good tolerability,which can obviously improve the prognosis and clinical survival time.
Objective:To investigate the curative effects of the Shenyi Capsule in the treatment of locally advanced cervical cancer.Methods:One hundred and seven patients with locally advanced cervical cancer were randomly divided into the observation group(54 cases) and control group(53 cases).The control group was treated with the concurrent chemoradiotherapy,and the observation group was treated with Shenyi Capsule combined with concurrent chemoradiotherapy until the disease progression.The short and long-term curative effects between two groups were compared.Results:After treatment,the 2-year survival rate in observation group was significantly higher than that in control group(P<0.05);and the distant metastasis rate in observation group was significantly lower than that in control group(P<0.05).The differences of the short-term effective and incidence rate of adverse reactions between two groups were not statistically significant(P>0.05).Conclusions:Shenyi Capsule combined with chemoradiotherapy in the treatment of locally advanced cervical cancer has good tolerability,which can obviously improve the prognosis and clinical survival time.
2017, 42(4): 447-450.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.009
Abstract:
Objective:To explore the correlation between the catestatin(CST) level and prognosis of patients with chronic heart failure(CHF).Methods:The general information and associated clinical data of 97 patients with CHF were collected,and 50 healthy people were set as the control at the same time.The relationships between the CST level,heart function classification and left ventricular ejection fraction(LVEF) in CHF patients were analyzed.All patients were followed up for 2 years.The ROC curves of CST level and recurrence of cardiovascular event within 2 years were drew.The patients were divided into the recurrence of cardiovascular event group and non-event group according to the occurrence of the cardiovascular event.The risk factors of the occurrence of the cardiovascular event were analyzed in CHF patients.Results:The level of CST in CHF patients was significantly higher than that in healthy people(P<0.01).The heart function classification and LVEF level were positively and negatively related to the CST level in CHF patients,respectively(P<0.01).Within 2 years of the following up,miss following up in 5 cases,recurrence of heart failure and hospitalization in 27 cases,and death in 4 cases were identified.On the basis of the ROC curve,the value of CST level(0.75 ng/mL) in predicting the recurrence of the cardiovascular event was higher in CHF patients,the sensitivity and specificity of which were 96.8% and 85.2%,respectively.Logistic regression analysis showed that the age increasing,LVEF decreasing and CST increasing were the independent risk factor of the reoccurrence of cardiovascular events in patients with CHF(P<0.01 to P<0.05).Conclusions:The CST level is related to the severity of disease in CHF patients,which has definite value in evaluating the prognosis of patients with CHF.
Objective:To explore the correlation between the catestatin(CST) level and prognosis of patients with chronic heart failure(CHF).Methods:The general information and associated clinical data of 97 patients with CHF were collected,and 50 healthy people were set as the control at the same time.The relationships between the CST level,heart function classification and left ventricular ejection fraction(LVEF) in CHF patients were analyzed.All patients were followed up for 2 years.The ROC curves of CST level and recurrence of cardiovascular event within 2 years were drew.The patients were divided into the recurrence of cardiovascular event group and non-event group according to the occurrence of the cardiovascular event.The risk factors of the occurrence of the cardiovascular event were analyzed in CHF patients.Results:The level of CST in CHF patients was significantly higher than that in healthy people(P<0.01).The heart function classification and LVEF level were positively and negatively related to the CST level in CHF patients,respectively(P<0.01).Within 2 years of the following up,miss following up in 5 cases,recurrence of heart failure and hospitalization in 27 cases,and death in 4 cases were identified.On the basis of the ROC curve,the value of CST level(0.75 ng/mL) in predicting the recurrence of the cardiovascular event was higher in CHF patients,the sensitivity and specificity of which were 96.8% and 85.2%,respectively.Logistic regression analysis showed that the age increasing,LVEF decreasing and CST increasing were the independent risk factor of the reoccurrence of cardiovascular events in patients with CHF(P<0.01 to P<0.05).Conclusions:The CST level is related to the severity of disease in CHF patients,which has definite value in evaluating the prognosis of patients with CHF.
2017, 42(4): 450-453.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.010
Abstract:
Objective:To investigate the effects of dexmedetomidine hydrochloride on the postoperative pain and early cognitive function of elderly patients treated with laparoscopy.Methods:Seventy-eight elderly patients treated with laparoscopy were divided into the observation group and control group according to the random number table(39 cases each group).The observation group and control group were treated with dexmedetomidine hydrochloride and 0.9% sodium chloride solution,respectively.The operation situation,pain score before and after treatment,postoperative MMSE score,adverse reactions and oxygen saturation in two groups were observed.Results:The difference of the operation condition between two groups was not statistically significant(P>0.05).The VAS scores 12 h,48 h and 72 h after operation in observation group were significantly lower than those in control group(P<0.01).The MMSE scores 6 h,24 h and 72 h after operation in observation group were significantly higher than those in control group(P<0.01).The incidence rate of adverse reaction in observation group(15.38%) was significantly lower than that in control group(61.54%)(P<0.01).Conclusions:The dexmedetomidine hydrochloride can effectively relieve pain,reduce the postoperative incidence of adverse reaction and cognitive dysfunction of elderly patients treated with laparoscopy,which can greatly improve the postoperative cognitive function of patients.
Objective:To investigate the effects of dexmedetomidine hydrochloride on the postoperative pain and early cognitive function of elderly patients treated with laparoscopy.Methods:Seventy-eight elderly patients treated with laparoscopy were divided into the observation group and control group according to the random number table(39 cases each group).The observation group and control group were treated with dexmedetomidine hydrochloride and 0.9% sodium chloride solution,respectively.The operation situation,pain score before and after treatment,postoperative MMSE score,adverse reactions and oxygen saturation in two groups were observed.Results:The difference of the operation condition between two groups was not statistically significant(P>0.05).The VAS scores 12 h,48 h and 72 h after operation in observation group were significantly lower than those in control group(P<0.01).The MMSE scores 6 h,24 h and 72 h after operation in observation group were significantly higher than those in control group(P<0.01).The incidence rate of adverse reaction in observation group(15.38%) was significantly lower than that in control group(61.54%)(P<0.01).Conclusions:The dexmedetomidine hydrochloride can effectively relieve pain,reduce the postoperative incidence of adverse reaction and cognitive dysfunction of elderly patients treated with laparoscopy,which can greatly improve the postoperative cognitive function of patients.
2017, 42(4): 454-457,461.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.011
Abstract:
Objective:To explore the preventive effects of nalmefene hydrochloride on the sufentanil-induced cough(SFIC) during induction of general anesthesia in cardiac surgery,and hemodynamics change during intubation.Methods:Sixty patients with ASA grade Ⅱ to Ⅲ scheduled by operation were randomly divided into the nalmefene group(group N) and control group(group C).Two groups were treated with 10 mg of diazepam by oral before 2 hours of operation and 0.3 mg of scopolamine by intramuscular injection before 30 minutes of operation.Group N and group C were intravenously injected with 0.25 μg/kg of nalmefene hydrochloride and the same volume of 0.9% sodium chloride 5 minutes before induction,respectively.The incidence rate and intensity of cough within 60 s in the intravenously injection of sufentanil in two groups were observed.The vital signs of two groups were recorded before the nalmefene injection(T0),before anesthesia induction(T1),at 60 s of sufentanil injection(T2) and intubation(T3).Results:The incidence rates of cough in group N and group C were 10.00% and 60.00%,respectively,the difference of which was statistically significant(P<0.01).The difference of the cough intensity between two groups was statistically significant(P<0.05).The differences of the hemodynamics,heart rate and bispectral index at T2 between two groups were statistically significant(P<0.05),the difference of the oxygen saturation at T2 between two groups was not statistically significant(P>0.05),and the difference of the hemodynamics at T3 between two groups was not statistically significant(P>0.05).Conclusions:Preventive injection of nalmefene can effectively reduce the incidence rate and intensity of sufentanil-induced cough during induction of general anesthesia in cardiac surgery,and the hemodynamic fluctuation caused by cough,which do not affect the reaction of intubation.
Objective:To explore the preventive effects of nalmefene hydrochloride on the sufentanil-induced cough(SFIC) during induction of general anesthesia in cardiac surgery,and hemodynamics change during intubation.Methods:Sixty patients with ASA grade Ⅱ to Ⅲ scheduled by operation were randomly divided into the nalmefene group(group N) and control group(group C).Two groups were treated with 10 mg of diazepam by oral before 2 hours of operation and 0.3 mg of scopolamine by intramuscular injection before 30 minutes of operation.Group N and group C were intravenously injected with 0.25 μg/kg of nalmefene hydrochloride and the same volume of 0.9% sodium chloride 5 minutes before induction,respectively.The incidence rate and intensity of cough within 60 s in the intravenously injection of sufentanil in two groups were observed.The vital signs of two groups were recorded before the nalmefene injection(T0),before anesthesia induction(T1),at 60 s of sufentanil injection(T2) and intubation(T3).Results:The incidence rates of cough in group N and group C were 10.00% and 60.00%,respectively,the difference of which was statistically significant(P<0.01).The difference of the cough intensity between two groups was statistically significant(P<0.05).The differences of the hemodynamics,heart rate and bispectral index at T2 between two groups were statistically significant(P<0.05),the difference of the oxygen saturation at T2 between two groups was not statistically significant(P>0.05),and the difference of the hemodynamics at T3 between two groups was not statistically significant(P>0.05).Conclusions:Preventive injection of nalmefene can effectively reduce the incidence rate and intensity of sufentanil-induced cough during induction of general anesthesia in cardiac surgery,and the hemodynamic fluctuation caused by cough,which do not affect the reaction of intubation.
2017, 42(4): 458-461.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.012
Abstract:
Objective:To investigate the clinical efficacy of clopidogrel combined with enteric-coated aspirin in the treatment of acute myocardial infarction(AMI).Methods:Ninety-one patients with AMI were randomly divided into the control group(45 cases) and observation group(46 cases).The control group was treated with aspirin on the basis of conventional treatment,and the observation group was treated with clopidogrel combined with enteric-coated aspirin on the basis of conventional treatment.After 3 months of treatment,the total effective rate,improvement of heart function,change of blood coagulation function and complications between two groups were compared.Results:After 3 months of treatment,the total effective rate in observation group(95.65%) was higher than that of control group(80%)(P<0.05).After treatment,the cardiac function in two groups was significantly improved than before(P<0.01),and the improvement of cardiac function in observation group was more obvious than that in control group(P<0.01).The differences of the 4 indexes of coagulation function between before and after treatment in control group were not statistically significant(P>0.05),but the prothrombin time in observation group increased after treatment(P<0.01).After 3 months,the incidence rate of vascular reocclusion in observation group significantly decreased(P<0.05),and the difference of complication between two groups was not statistically significant(P>0.05).Conclusions:The effect of clopidogrel combined with enteric coated aspirin in the treatment of AMI is significant,which can obviously improve the cardiac function and coagulation function of patients,and has important significance in improving the prognosis of patients.
Objective:To investigate the clinical efficacy of clopidogrel combined with enteric-coated aspirin in the treatment of acute myocardial infarction(AMI).Methods:Ninety-one patients with AMI were randomly divided into the control group(45 cases) and observation group(46 cases).The control group was treated with aspirin on the basis of conventional treatment,and the observation group was treated with clopidogrel combined with enteric-coated aspirin on the basis of conventional treatment.After 3 months of treatment,the total effective rate,improvement of heart function,change of blood coagulation function and complications between two groups were compared.Results:After 3 months of treatment,the total effective rate in observation group(95.65%) was higher than that of control group(80%)(P<0.05).After treatment,the cardiac function in two groups was significantly improved than before(P<0.01),and the improvement of cardiac function in observation group was more obvious than that in control group(P<0.01).The differences of the 4 indexes of coagulation function between before and after treatment in control group were not statistically significant(P>0.05),but the prothrombin time in observation group increased after treatment(P<0.01).After 3 months,the incidence rate of vascular reocclusion in observation group significantly decreased(P<0.05),and the difference of complication between two groups was not statistically significant(P>0.05).Conclusions:The effect of clopidogrel combined with enteric coated aspirin in the treatment of AMI is significant,which can obviously improve the cardiac function and coagulation function of patients,and has important significance in improving the prognosis of patients.
2017, 42(4): 462-464,468.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.013
Abstract:
Objective:To investigate the effects of flurbiprofen,dezocine,flurbiprofen combined with dezocine on relieving postoperative hyperalgesia induced by remifentanil.Methods:One hundred and twenty patients scheduled by laparoscopic surgery were anesthesized using conventional remifentanil.The patients with ASA grade Ⅰto Ⅱ were divided into group F,group D and group F combined with D using random number method(40 cases each group).The group F was treated with 2 mg/kg of flurbiprofen axetil before anesthesia,and same volume of 0.9% NaCl injection before 30 min of the end of operation.The group D was treated with the same volume of 0.9% NaCl injection before anesthesia,and 0.2 mg/kg of dezocine before 30 min of the end of operation.The group D combined with F was treated with 1 mg/kg of flurbiprofen axetil before anesthesia,and 0.1 mg/kg of dezocine before 30 min of the end of operation.The mean arterial pressure and heart rate in three groups were observed and recorded at the end of sewing skin(T1),extubating laryngeal mask(T2) and 30 min after extubating laryngeal mask(T3).The incidence rates of nausea,vomiting,dizziness and somnolence,and VAS score in three groups were recorded.Results:The differences of the levels of the mean arterial pressure and heart rate at T1,T2 and T3 between three groups were not statistically significant(P>0.05).The differences of the incidence rates of nausea,vomiting,dizziness and somnolence after operation between three groups were statistically significant(P<0.01).Compared with group D and group F combined with D,the incidence rates of postoperative nausea and vomiting in group F significantly increased(P<0.01).Compared with group F and group F combined with D,the incidence rates of postoperative dizziness and somnolence in D group significantly increased(P<0.01).During the postoperative recovery period,the differences of the VAS scores between three groups were statistical significance(P<0.01),the differences of the VAS scores between group F combined with D and group F,and between group F combined with D and group D were statistically significant(P<0.01),and the difference of the VAS score between group F and group D was not statistically significant(P>0.05).Conclusions:The effect of flurbiprofen combined with dezocine on relieving postoperative hyperalgesia induced by remifentanil is better than that of flurbiprofen or dezocine.
Objective:To investigate the effects of flurbiprofen,dezocine,flurbiprofen combined with dezocine on relieving postoperative hyperalgesia induced by remifentanil.Methods:One hundred and twenty patients scheduled by laparoscopic surgery were anesthesized using conventional remifentanil.The patients with ASA grade Ⅰto Ⅱ were divided into group F,group D and group F combined with D using random number method(40 cases each group).The group F was treated with 2 mg/kg of flurbiprofen axetil before anesthesia,and same volume of 0.9% NaCl injection before 30 min of the end of operation.The group D was treated with the same volume of 0.9% NaCl injection before anesthesia,and 0.2 mg/kg of dezocine before 30 min of the end of operation.The group D combined with F was treated with 1 mg/kg of flurbiprofen axetil before anesthesia,and 0.1 mg/kg of dezocine before 30 min of the end of operation.The mean arterial pressure and heart rate in three groups were observed and recorded at the end of sewing skin(T1),extubating laryngeal mask(T2) and 30 min after extubating laryngeal mask(T3).The incidence rates of nausea,vomiting,dizziness and somnolence,and VAS score in three groups were recorded.Results:The differences of the levels of the mean arterial pressure and heart rate at T1,T2 and T3 between three groups were not statistically significant(P>0.05).The differences of the incidence rates of nausea,vomiting,dizziness and somnolence after operation between three groups were statistically significant(P<0.01).Compared with group D and group F combined with D,the incidence rates of postoperative nausea and vomiting in group F significantly increased(P<0.01).Compared with group F and group F combined with D,the incidence rates of postoperative dizziness and somnolence in D group significantly increased(P<0.01).During the postoperative recovery period,the differences of the VAS scores between three groups were statistical significance(P<0.01),the differences of the VAS scores between group F combined with D and group F,and between group F combined with D and group D were statistically significant(P<0.01),and the difference of the VAS score between group F and group D was not statistically significant(P>0.05).Conclusions:The effect of flurbiprofen combined with dezocine on relieving postoperative hyperalgesia induced by remifentanil is better than that of flurbiprofen or dezocine.
2017, 42(4): 465-468.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.014
Abstract:
Objective:To investigate the short-term effects and long-term influences of short-term intensive insulin therapy on type 2 diabetes mellitus(T2DM).Methods:One hundred and thirty patients with T2DM were treated with intensive insulin for 2 weeks,and followed up for 12 months.The levels of fasting plasma glucose(FPG),2 h plasma glucose(2hPG),glycosylated hemoglobin(HbA1c),blood lipid,interleukin-6(IL-6) and procalcitonin in patients between before and after treatment were compared.The insulin resistance and islet β-cell function were evaluated using homeostasis method.The alleviating rate was counted during the 12 months of following up.Results:Compared with before treatment,the levels of FPG,2hPG,HbA1c,IL-6,procalcitonin and insulin resistance significantly decreased(P<0.01),and the islet β-cell function significantly increased after treatment(P<0.01).Compared with before treatment,the levels of FPG,2hPG,HbA1c,low density lipoprotein cholesterol and high density lipoprotein cholesterol significantly decreased(P<0.01),and the total alleviating rate of patients was 42.31%(55/130) after 12 months of following up.The alleviating rate in patients with disease course < 3 months,3 months to 1 year,> 1 to 5 years,> 5 to 10 years,> 10 to 15 years and > 15 years were 81.82%(18/22),71.43%(15/21),54.55%(12/22),31.82%(7/22),13.64%(3/22) and 0.00%(0/21),respectively.The disease course in alleviating patients was significantly shorter than that in nonalleviating patients(P<0.01).Conclusions:The short-term intensive insulin therapy can protect the islet function and improve the insulin resistance of T2DM patients.
Objective:To investigate the short-term effects and long-term influences of short-term intensive insulin therapy on type 2 diabetes mellitus(T2DM).Methods:One hundred and thirty patients with T2DM were treated with intensive insulin for 2 weeks,and followed up for 12 months.The levels of fasting plasma glucose(FPG),2 h plasma glucose(2hPG),glycosylated hemoglobin(HbA1c),blood lipid,interleukin-6(IL-6) and procalcitonin in patients between before and after treatment were compared.The insulin resistance and islet β-cell function were evaluated using homeostasis method.The alleviating rate was counted during the 12 months of following up.Results:Compared with before treatment,the levels of FPG,2hPG,HbA1c,IL-6,procalcitonin and insulin resistance significantly decreased(P<0.01),and the islet β-cell function significantly increased after treatment(P<0.01).Compared with before treatment,the levels of FPG,2hPG,HbA1c,low density lipoprotein cholesterol and high density lipoprotein cholesterol significantly decreased(P<0.01),and the total alleviating rate of patients was 42.31%(55/130) after 12 months of following up.The alleviating rate in patients with disease course < 3 months,3 months to 1 year,> 1 to 5 years,> 5 to 10 years,> 10 to 15 years and > 15 years were 81.82%(18/22),71.43%(15/21),54.55%(12/22),31.82%(7/22),13.64%(3/22) and 0.00%(0/21),respectively.The disease course in alleviating patients was significantly shorter than that in nonalleviating patients(P<0.01).Conclusions:The short-term intensive insulin therapy can protect the islet function and improve the insulin resistance of T2DM patients.
2017, 42(4): 469-471.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.015
Abstract:
Objective:To observe the efficacy and safety of dexmedetomidine(Dex) in cardiopulmonary bypass(CPB) surgery.Methods:One hundred and twenty heart disease patients scheduled by CPB surgery were randomly divided into the control group(group C) and observation group(group D)(60 cases each group).The control group was generally anesthetized induction with 0.05 mg/kg of midazolam,0.2 to 0.3 μg/kg of sufentanil,1 to 2 mg/kg of propofol and 0.2 mg/kg of cisatracurium,and sufentanyl was continuously infused at the rate of 0.1 μg·kg-1·h-1 until the end of CPB after endotracheal intubation.The 1 μg/kg of Dex in group D was infused for 10 min before anesthesia,The group D was intubated under general anesthesia induction as the group C after 5 min of infusion of Dex,and then continuously infused with Dex at the rate of 0.5 μg·kg-1·h-1 until the end of CPB.The heart rate and average arterial pressure in two groups were recorded at each time-point.The levels of venous serum cortisol(COR) and aldosterone(ALD) in two groups were compared.The Dex-related adverse reactions(hypotension,hypertension,bradycardia and cardiac arrest) and incidence rates of adverse reactions(lung infection,cognitive function,stroke,paralysis and death) within 2 weeks after operation were recorded.Results:Compared with group C,the heart rate and average arterial pressure at each time-point in group D were lower(P <0.05 to P <0.01).The levels of COR and ALD in group D were lower than those in group C(P<0.01).The difference of the incidence rate of adverse reaction within 2 weeks after operation between two groups was not statistically significant(P>0.05).Conclusions:The application of Dex in CPB surgery can alleviate the hemodynamic fluctuation during operation,decrease the serum COR and ALD levels,reduce stress reactions and improve the perioperative quality of rehabilitation of patients to some extent,which is worthy of promotion.
Objective:To observe the efficacy and safety of dexmedetomidine(Dex) in cardiopulmonary bypass(CPB) surgery.Methods:One hundred and twenty heart disease patients scheduled by CPB surgery were randomly divided into the control group(group C) and observation group(group D)(60 cases each group).The control group was generally anesthetized induction with 0.05 mg/kg of midazolam,0.2 to 0.3 μg/kg of sufentanil,1 to 2 mg/kg of propofol and 0.2 mg/kg of cisatracurium,and sufentanyl was continuously infused at the rate of 0.1 μg·kg-1·h-1 until the end of CPB after endotracheal intubation.The 1 μg/kg of Dex in group D was infused for 10 min before anesthesia,The group D was intubated under general anesthesia induction as the group C after 5 min of infusion of Dex,and then continuously infused with Dex at the rate of 0.5 μg·kg-1·h-1 until the end of CPB.The heart rate and average arterial pressure in two groups were recorded at each time-point.The levels of venous serum cortisol(COR) and aldosterone(ALD) in two groups were compared.The Dex-related adverse reactions(hypotension,hypertension,bradycardia and cardiac arrest) and incidence rates of adverse reactions(lung infection,cognitive function,stroke,paralysis and death) within 2 weeks after operation were recorded.Results:Compared with group C,the heart rate and average arterial pressure at each time-point in group D were lower(P <0.05 to P <0.01).The levels of COR and ALD in group D were lower than those in group C(P<0.01).The difference of the incidence rate of adverse reaction within 2 weeks after operation between two groups was not statistically significant(P>0.05).Conclusions:The application of Dex in CPB surgery can alleviate the hemodynamic fluctuation during operation,decrease the serum COR and ALD levels,reduce stress reactions and improve the perioperative quality of rehabilitation of patients to some extent,which is worthy of promotion.
2017, 42(4): 472-473,476.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.016
Abstract:
Objective:To compare the effects between hemodialysis and peritoneal dialysis on calcium and phosphorus metabolism in patients with uremia.Methods:The clinical data of 52 patients with uremia were retrospectively analyzed.Twenty-eight cases treated with peritoneal dialysis and 24 cases treated with hemodialysis were divided into the peritoneal dialysis group and hemodialysis group,respectively.The levels of the parathyroid hormone,serum phosphorus and calcium in two groups were measured at treatment,and 3 and 6 months after treatment.The incidence rate of abnormal situation between two groups was compared.Results:The levels of serum phosphorus in peritoneal dialysis group at treatment and 6 months after treatment were lower than that in hemodialysis group(P<0.05).The level of parathyroid hormone in peritoneal dialysis group at treatment was significantly lower than that in hemodialysis group(P<0.05).The incidence rate of high phosphorus in peritoneal dialysis group was significantly lower than that in hemodialysis group(P<0.05).The differences of the incidence rate of low phosphorus,high and low calcium and parathyroid hormone between two groups were not statistically significant(P>0.05).Conclusions:The peritoneal dialysis can effectively protect the residual renal function and control the calcium and phosphorus metabolism,which is worthy of clinical application.
Objective:To compare the effects between hemodialysis and peritoneal dialysis on calcium and phosphorus metabolism in patients with uremia.Methods:The clinical data of 52 patients with uremia were retrospectively analyzed.Twenty-eight cases treated with peritoneal dialysis and 24 cases treated with hemodialysis were divided into the peritoneal dialysis group and hemodialysis group,respectively.The levels of the parathyroid hormone,serum phosphorus and calcium in two groups were measured at treatment,and 3 and 6 months after treatment.The incidence rate of abnormal situation between two groups was compared.Results:The levels of serum phosphorus in peritoneal dialysis group at treatment and 6 months after treatment were lower than that in hemodialysis group(P<0.05).The level of parathyroid hormone in peritoneal dialysis group at treatment was significantly lower than that in hemodialysis group(P<0.05).The incidence rate of high phosphorus in peritoneal dialysis group was significantly lower than that in hemodialysis group(P<0.05).The differences of the incidence rate of low phosphorus,high and low calcium and parathyroid hormone between two groups were not statistically significant(P>0.05).Conclusions:The peritoneal dialysis can effectively protect the residual renal function and control the calcium and phosphorus metabolism,which is worthy of clinical application.
2017, 42(4): 474-476.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.017
Abstract:
Objective:To explore the value of the mastoscopic surgery in the treatment of breast benign diseases.Methods:One hundred and two patients with breast disease were divided into the mastoscopic surgery group(49 cases) and modified mastoscopic surgery group(53 cases).The operation time,incision healing and incidence rate of complication between two groups were compared.Results:The operation and wound healing times in modified mastoscopic surgery group were obviously shorter than those in mastoscopic surgery group(P<0.01).The differences of the incidence rates of incision scar healing,nipple flap necrosis,limited upper limb activity and paralysis between two groups were not statistically significant(P>0.05),but the incidence rate of pain in modified mastoscopic surgery group was less than that in mastoscopic surgery group(P<0.05).Conclusions:The modified mastoscopic surgery greatly simplifies the operation process,shortens the operation time,and reduces the incidence of pain.
Objective:To explore the value of the mastoscopic surgery in the treatment of breast benign diseases.Methods:One hundred and two patients with breast disease were divided into the mastoscopic surgery group(49 cases) and modified mastoscopic surgery group(53 cases).The operation time,incision healing and incidence rate of complication between two groups were compared.Results:The operation and wound healing times in modified mastoscopic surgery group were obviously shorter than those in mastoscopic surgery group(P<0.01).The differences of the incidence rates of incision scar healing,nipple flap necrosis,limited upper limb activity and paralysis between two groups were not statistically significant(P>0.05),but the incidence rate of pain in modified mastoscopic surgery group was less than that in mastoscopic surgery group(P<0.05).Conclusions:The modified mastoscopic surgery greatly simplifies the operation process,shortens the operation time,and reduces the incidence of pain.
2017, 42(4): 477-480.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.018
Abstract:
Objective:To explore the safety and validity of the percutaneous coronary intervention(PCI) via brachial artery.Methods:The PCI patients from March 2009 to September 2013 were divided into the brachial artery group(40 cases),radial artery group(80 cases) and femoral artery group(85 cases) according to the operation path.The success rate and time of puncture,success rate of complex lesion operation,surgical complication and prognosis between three groups were compared.Results:The puncture time and operation time in brachial artery group were less than those in radial artery group(P<0.01),the success rates of the puncture and complex lesion operation in the three groups have statistical significance(P<0.01 and P<0.05).The hospitalization time in brachial artery group was less than that in femoral artery group(P<0.01),and the surgical complication in brachial artery group was less than that in femoral artery group(P<0.05).The differences of the prognosis between three groups were not statistically significant(P>0.05).Conclusions:The PCI via brachial artery is a safe and effective operation approach,which has great value in clinical application.
Objective:To explore the safety and validity of the percutaneous coronary intervention(PCI) via brachial artery.Methods:The PCI patients from March 2009 to September 2013 were divided into the brachial artery group(40 cases),radial artery group(80 cases) and femoral artery group(85 cases) according to the operation path.The success rate and time of puncture,success rate of complex lesion operation,surgical complication and prognosis between three groups were compared.Results:The puncture time and operation time in brachial artery group were less than those in radial artery group(P<0.01),the success rates of the puncture and complex lesion operation in the three groups have statistical significance(P<0.01 and P<0.05).The hospitalization time in brachial artery group was less than that in femoral artery group(P<0.01),and the surgical complication in brachial artery group was less than that in femoral artery group(P<0.05).The differences of the prognosis between three groups were not statistically significant(P>0.05).Conclusions:The PCI via brachial artery is a safe and effective operation approach,which has great value in clinical application.
2017, 42(4): 483-486,490.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.020
Abstract:
Objective:To explore the correlations between the parents' teaching way,understanding social support and health literacy in college students.Methods:One thousand seven hundred and eighty-three students from three colleges of Bengbu were investigated using the parents' teaching way questionnaire,understanding social support scale,general demographic information and health literacy questionnaire.Results:The scores of the students' health literacy,health knowledge and belief,healthy life-style and behavior,and health skill were 61.11,62.75,51.98 and 80.80,respectively.Logistic regression analysis showed that the gender,grade,profession were the main influencing factors of the health literacy in college students.College students' health literacy was significantly negatively and positively correlated with the parents' rejection factors and parents' emotional warmth factors,respectively(P<0.01),and which was not correlated with parents' over protective factors.The health literacy of college students was significantly positive correlated with each dimension of understanding social support(P<0.01).Conclusions:The health literacy level of college students is low,and the three dimensions of which is unbalanced.The health skill level,and healthy lifestyle and behavior literacy levels in college students were higher and lower,respectively.The parents' emotional warmth style and understanding social support can improve the health literacy level of college students,but for the parental refusal rearing pattern,it is contrary.The gender,grade,profession,parental refusal,mother's emotional warmth,mother's excessive protection,total score of understanding social support,and friend support can affect the health literacy of college students.
Objective:To explore the correlations between the parents' teaching way,understanding social support and health literacy in college students.Methods:One thousand seven hundred and eighty-three students from three colleges of Bengbu were investigated using the parents' teaching way questionnaire,understanding social support scale,general demographic information and health literacy questionnaire.Results:The scores of the students' health literacy,health knowledge and belief,healthy life-style and behavior,and health skill were 61.11,62.75,51.98 and 80.80,respectively.Logistic regression analysis showed that the gender,grade,profession were the main influencing factors of the health literacy in college students.College students' health literacy was significantly negatively and positively correlated with the parents' rejection factors and parents' emotional warmth factors,respectively(P<0.01),and which was not correlated with parents' over protective factors.The health literacy of college students was significantly positive correlated with each dimension of understanding social support(P<0.01).Conclusions:The health literacy level of college students is low,and the three dimensions of which is unbalanced.The health skill level,and healthy lifestyle and behavior literacy levels in college students were higher and lower,respectively.The parents' emotional warmth style and understanding social support can improve the health literacy level of college students,but for the parental refusal rearing pattern,it is contrary.The gender,grade,profession,parental refusal,mother's emotional warmth,mother's excessive protection,total score of understanding social support,and friend support can affect the health literacy of college students.
2017, 42(4): 487-490.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.021
Abstract:
Objective:To investigate the physical exercise of medical college students,and analyze the effects of physical exercise on the self-confidence of students.Methods:One thousand and eight from the "Department of Clinical Medicine and Nursing" of a medical college were selected using stratified cluster sampling.The students were investigated using self-programming "Physical Exercise Questionnaire" and "College Student Self-confidence Questionnaire" in group way.Results:The average score of self-confidence of medical students was(240.02±35.55) points.In physical exercise,a small amount of exercise was taken by a majority of students(74.5%).The total score of self-confidence and each dimension score in the students taking moderate and large intensity exercise were higher than those in the students taking small intensity exercise(P<0.01).Multiple linear regression results showed that the self-confidence in male,lower grade,and high maternal educational level and large intensity exercise students were higher(P <0.05 to P <0.01).The self-confidence in "Medical Imaging Department" was higher than that in "Preventive Medicine Department"(P<0.05).Conclusions:The self-confidence levels in the students taking moderate and large intensity exercise are higher than that in the students taking small intensity exercise.The self-confidence levels in male,lower grade,high maternal educational level and large intensity exercise medical students are more high.
Objective:To investigate the physical exercise of medical college students,and analyze the effects of physical exercise on the self-confidence of students.Methods:One thousand and eight from the "Department of Clinical Medicine and Nursing" of a medical college were selected using stratified cluster sampling.The students were investigated using self-programming "Physical Exercise Questionnaire" and "College Student Self-confidence Questionnaire" in group way.Results:The average score of self-confidence of medical students was(240.02±35.55) points.In physical exercise,a small amount of exercise was taken by a majority of students(74.5%).The total score of self-confidence and each dimension score in the students taking moderate and large intensity exercise were higher than those in the students taking small intensity exercise(P<0.01).Multiple linear regression results showed that the self-confidence in male,lower grade,and high maternal educational level and large intensity exercise students were higher(P <0.05 to P <0.01).The self-confidence in "Medical Imaging Department" was higher than that in "Preventive Medicine Department"(P<0.05).Conclusions:The self-confidence levels in the students taking moderate and large intensity exercise are higher than that in the students taking small intensity exercise.The self-confidence levels in male,lower grade,high maternal educational level and large intensity exercise medical students are more high.
2017, 42(4): 491-494,507.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.022
Abstract:
Objective:To explore the relationship between social anxiety and rearing condition in senior pupils in rural area,and provide the scientific reference in developing the intervention measure.Methods:One thousand and twenty-six pupils(including 265 forth grade students,291 fifth grade students and 296 sixth grade students,455 boys and 397 girls,and 347 non-left-behind children and 505 left-behind children) in Bengbu and Suzhou were enrolled using the method of stratified cluster random sampling.The pupils were investigated by questionnaire,the content of which included rearing condition and social anxiety of pupils.Results:The differences of the total scores of social anxiety among the three grades in rural area pupils were not statistically significant(P>0.05),but the scores of two dimensions and fear of negative evaluation in fifth grade and sixth grade were higher than those in forth grade(P <0.01 and P <0.05),and the score of the social avoidance in forth grade was higher than that in sixth grade(P<0.05).The differences of the total score of social anxiety and two dimensions of different sex and left-behind type pupils were not statistically significant(P>0.05).The analysis of the relationship between social anxiety and rearing condition showed that the duration of going-out-for-working of father,visiting frequency of father,father's attitude to children's mistakes and mother's concern had certain effects on social anxiety level(P<0.05).Conclusions:Improving the rearing condition of children in rural area(increasing visiting frequency,improving father's attitude to children's mistakes and changing mother's care for their children's direction and way) can reduce the level of social anxiety of children to a certain degree.
Objective:To explore the relationship between social anxiety and rearing condition in senior pupils in rural area,and provide the scientific reference in developing the intervention measure.Methods:One thousand and twenty-six pupils(including 265 forth grade students,291 fifth grade students and 296 sixth grade students,455 boys and 397 girls,and 347 non-left-behind children and 505 left-behind children) in Bengbu and Suzhou were enrolled using the method of stratified cluster random sampling.The pupils were investigated by questionnaire,the content of which included rearing condition and social anxiety of pupils.Results:The differences of the total scores of social anxiety among the three grades in rural area pupils were not statistically significant(P>0.05),but the scores of two dimensions and fear of negative evaluation in fifth grade and sixth grade were higher than those in forth grade(P <0.01 and P <0.05),and the score of the social avoidance in forth grade was higher than that in sixth grade(P<0.05).The differences of the total score of social anxiety and two dimensions of different sex and left-behind type pupils were not statistically significant(P>0.05).The analysis of the relationship between social anxiety and rearing condition showed that the duration of going-out-for-working of father,visiting frequency of father,father's attitude to children's mistakes and mother's concern had certain effects on social anxiety level(P<0.05).Conclusions:Improving the rearing condition of children in rural area(increasing visiting frequency,improving father's attitude to children's mistakes and changing mother's care for their children's direction and way) can reduce the level of social anxiety of children to a certain degree.
2017, 42(4): 495-498.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.023
Abstract:
Objective:To investigate the consumption of antibacterials and the drug resistance of the bacteria isolated from clinical samples for rational use of antibacterials.Methods:The defined daily dose(DDDs) of inpatients and the drug resistance of the bacteria isolated from clinical samples in 2012-2013 were analyzed.Results:In the 2 years from 2012 to 2013,the main clinical drug selection was cephalosporins,quinolones,cephamycins and other β-lactamase inhibitors.The drugs of great variation of DDDs included cefuroxime,ceftriaxone,cefmetazole,cefoxitin,pazufloxacin and fosfomycin.In 2013,the resistance rates of Escherichia coli,Pseudomonas aeruginosa all increased for cefuroxime,cefmetazole and fosfomycin(P <0.05 to P <0.01);the resistance rate of Acinetobacter baumannii all exceed 80% for cefmetazol and fosfomycin(P <0.05 and P <0.01),the resistance rate of Staphylococcus aureus increased significantly for levofloxacin(P<0.01).Conclusions:There was a positive correlation between the DDDs and bacterial resistance,with the increasing of DDDs,the bacterial resistance increased significantly;when DDDs fell,portion of bacterial resistance decreased.Active surveillance of bacterial resistance in hospital and effective measures to control the amount of antibacterials,guidance of clinical rational drug use should be carried out to reduce bacterial resistance.
Objective:To investigate the consumption of antibacterials and the drug resistance of the bacteria isolated from clinical samples for rational use of antibacterials.Methods:The defined daily dose(DDDs) of inpatients and the drug resistance of the bacteria isolated from clinical samples in 2012-2013 were analyzed.Results:In the 2 years from 2012 to 2013,the main clinical drug selection was cephalosporins,quinolones,cephamycins and other β-lactamase inhibitors.The drugs of great variation of DDDs included cefuroxime,ceftriaxone,cefmetazole,cefoxitin,pazufloxacin and fosfomycin.In 2013,the resistance rates of Escherichia coli,Pseudomonas aeruginosa all increased for cefuroxime,cefmetazole and fosfomycin(P <0.05 to P <0.01);the resistance rate of Acinetobacter baumannii all exceed 80% for cefmetazol and fosfomycin(P <0.05 and P <0.01),the resistance rate of Staphylococcus aureus increased significantly for levofloxacin(P<0.01).Conclusions:There was a positive correlation between the DDDs and bacterial resistance,with the increasing of DDDs,the bacterial resistance increased significantly;when DDDs fell,portion of bacterial resistance decreased.Active surveillance of bacterial resistance in hospital and effective measures to control the amount of antibacterials,guidance of clinical rational drug use should be carried out to reduce bacterial resistance.
2017, 42(4): 499-502.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.024
Abstract:
Objective:To investigate the postoperative use of antimicrobials in patients treated with laparoscopic cholecystectomy(LC),and evaluate the economic effectiveness of different antimicrobial solutions.Methods:The clinical data of 208 patients treated with LC were retrospectively analyzed.The patients were divided into three groups according to the postoperative use of antimicrobials.The variety of drug,administration duration and administration cost in three kinds of the highest use frequency of antimicrobials were statistically analyzed.The ratio of cost to effectiveness between three solutions was compared using the cost-effectiveness analysis method.Results:Eighteen administration solutions(involving 10 varieties of drugs) in 208 cases were identified.The use frequency of the second generation cephalosporins and nitroimidazoles was the highest.The highest use frequency of antimicrobials in patients was the group A(cefuroxime),group B(cefuroxime and ornidazole) and group P(ceftriaxone and ornidazole).The effective rates in group A,B and P were 97.26%,100.00% and 100%,respectively,the differences of which between three groups were not statistically significant(P>0.05).The difference of the drug cost between group A and group B was statistically significant(P<0.01),but the differences of the drug cost between group A and group P,and between group B and group P were not statistically significant(P>0.05).After the antimicrobial drug price was downregulated by 10%,the difference of the drug cost between group A and group B was statistically significant(P<0.05),but the differences of the drug cost between group A and group P,and between group B and group P were not statistically significant(P>0.05).Conclusions:The postoperative uses of cefuroxime,ceftriaxone or combination with ornidazole in patients treated with LC are safe and effective.The postoperative use of cefuroxime is the best solution.
Objective:To investigate the postoperative use of antimicrobials in patients treated with laparoscopic cholecystectomy(LC),and evaluate the economic effectiveness of different antimicrobial solutions.Methods:The clinical data of 208 patients treated with LC were retrospectively analyzed.The patients were divided into three groups according to the postoperative use of antimicrobials.The variety of drug,administration duration and administration cost in three kinds of the highest use frequency of antimicrobials were statistically analyzed.The ratio of cost to effectiveness between three solutions was compared using the cost-effectiveness analysis method.Results:Eighteen administration solutions(involving 10 varieties of drugs) in 208 cases were identified.The use frequency of the second generation cephalosporins and nitroimidazoles was the highest.The highest use frequency of antimicrobials in patients was the group A(cefuroxime),group B(cefuroxime and ornidazole) and group P(ceftriaxone and ornidazole).The effective rates in group A,B and P were 97.26%,100.00% and 100%,respectively,the differences of which between three groups were not statistically significant(P>0.05).The difference of the drug cost between group A and group B was statistically significant(P<0.01),but the differences of the drug cost between group A and group P,and between group B and group P were not statistically significant(P>0.05).After the antimicrobial drug price was downregulated by 10%,the difference of the drug cost between group A and group B was statistically significant(P<0.05),but the differences of the drug cost between group A and group P,and between group B and group P were not statistically significant(P>0.05).Conclusions:The postoperative uses of cefuroxime,ceftriaxone or combination with ornidazole in patients treated with LC are safe and effective.The postoperative use of cefuroxime is the best solution.
2017, 42(4): 502-504.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.025
Abstract:
Objective:To investigate the application value of the five-item detection of aerobic vaginitis/bacterial vaginosis(AV/BV) in the evaluation of vaginal microflora.Methods:One hundred and ten healthy examination women were investigated from December 2012 to January 2015.The vaginal pH,Gram staining and cleanliness in all cases were detected using conventional methods,which was used to analyze the vaginal flora.The five-item detection of AV/BV was implemented.Results:The normal vaginal flora in 42 cases(38.18%) and abnormal vaginal flora in 68 cases(61.82%) were identified.The preformed enzyme positive rate in female cases with abnormal vaginal flora was significantly higher than that in female cases with normal vaginal flora(P <0.05 to P <0.01).Conclusions:The five-item detection of AV/BV is simple,safe,reliable,accurate and high sensitive,which can be used as a rapid screening method in clinic,and be more effective to evaluate the vaginal microflora.
Objective:To investigate the application value of the five-item detection of aerobic vaginitis/bacterial vaginosis(AV/BV) in the evaluation of vaginal microflora.Methods:One hundred and ten healthy examination women were investigated from December 2012 to January 2015.The vaginal pH,Gram staining and cleanliness in all cases were detected using conventional methods,which was used to analyze the vaginal flora.The five-item detection of AV/BV was implemented.Results:The normal vaginal flora in 42 cases(38.18%) and abnormal vaginal flora in 68 cases(61.82%) were identified.The preformed enzyme positive rate in female cases with abnormal vaginal flora was significantly higher than that in female cases with normal vaginal flora(P <0.05 to P <0.01).Conclusions:The five-item detection of AV/BV is simple,safe,reliable,accurate and high sensitive,which can be used as a rapid screening method in clinic,and be more effective to evaluate the vaginal microflora.
2017, 42(4): 505-507.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.026
Abstract:
Objective:To investigate the differences of the positive detection rate between different day-age,different blood group of mother-baby,and "direct antiglobulin test,indirect antiglobulin test and dilution test" of child in hemolytic disease of the newborn(HDN).Methods:The ABO and Rh(D) blood groups in mother-baby were identified using the micro-column gel agglutination assay.The direct antiglobulin test,indirect antiglobulin test and dilution test in children,and the irregular antibody in mother with negative Rh(D) were examined.The positive rates of the different day-age,blood group of mother-baby and "three tests" in detecting the hemolysis were analyzed.Results:Among 418 neonates with high bilirubin,186 cases were diagnosed as HDN,the total positive rate of which was 44.50%.Among 186 HDN children,the neonates ≤ 3 days old in 125 cases(49.21%),neonates > 3 days and ≤ 7 days in 38 cases(39.18%),and neonates > 7 days in 23 cases(34.33%) were identified,the difference of which was statistically significant(P<0.05).The blood group of mother-baby as O-A in 95 cases(66.90%) and O-B in 91 cases(57.96%) were found,the difference of which was not statistically significant(P>0.05).The positive rates of the direct antiglobulin test,indirect antiglobulin test and dilution test were 7.66%,31.82% and 44.50%,respectively.Conclusions:The most common type of HDN is ABO-HDN,the detection rate of neonates ≤ 3 days old is the highest,and the positive rate of dilution test is highest,which can be used as the directly diagnostic basis of HDN.
Objective:To investigate the differences of the positive detection rate between different day-age,different blood group of mother-baby,and "direct antiglobulin test,indirect antiglobulin test and dilution test" of child in hemolytic disease of the newborn(HDN).Methods:The ABO and Rh(D) blood groups in mother-baby were identified using the micro-column gel agglutination assay.The direct antiglobulin test,indirect antiglobulin test and dilution test in children,and the irregular antibody in mother with negative Rh(D) were examined.The positive rates of the different day-age,blood group of mother-baby and "three tests" in detecting the hemolysis were analyzed.Results:Among 418 neonates with high bilirubin,186 cases were diagnosed as HDN,the total positive rate of which was 44.50%.Among 186 HDN children,the neonates ≤ 3 days old in 125 cases(49.21%),neonates > 3 days and ≤ 7 days in 38 cases(39.18%),and neonates > 7 days in 23 cases(34.33%) were identified,the difference of which was statistically significant(P<0.05).The blood group of mother-baby as O-A in 95 cases(66.90%) and O-B in 91 cases(57.96%) were found,the difference of which was not statistically significant(P>0.05).The positive rates of the direct antiglobulin test,indirect antiglobulin test and dilution test were 7.66%,31.82% and 44.50%,respectively.Conclusions:The most common type of HDN is ABO-HDN,the detection rate of neonates ≤ 3 days old is the highest,and the positive rate of dilution test is highest,which can be used as the directly diagnostic basis of HDN.
2017, 42(4): 508-510.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.027
Abstract:
Objective:To screen the risk factors of breast cancer in Bengbu women,establish the risk assessment model of breast cancer,investigate the cut-off points of low,medium and high risk,and assess the probability of breast cancer in women with specific risk factor.Methods:The risk factors of breast cancer were screened by logistic regression,and which was used to establish the risk assessment model of breast cancer.The risk model was evaluated using Fisher.The model performance was examined by the area under the ROC curve,and the appropriate low,medium and high risk cut-off points were distinguished by the ROC curve.Results:The family economy condition,eating bean product,releasing negative emotion,work intensity and screening breast cancer were the main risk factors of breast cancer(P <0.05 to P <0.01).The risk model showed that the women with P ≤ 0.49,0.49 <P <0.51 and P ≥ 0.51 were low,medium and high risk populations,respectively.Conclusions:The model can assess the probability of breast cancer in Bengbu women with specific risk factor,and provide certain basis in establishing the screening criteria.
Objective:To screen the risk factors of breast cancer in Bengbu women,establish the risk assessment model of breast cancer,investigate the cut-off points of low,medium and high risk,and assess the probability of breast cancer in women with specific risk factor.Methods:The risk factors of breast cancer were screened by logistic regression,and which was used to establish the risk assessment model of breast cancer.The risk model was evaluated using Fisher.The model performance was examined by the area under the ROC curve,and the appropriate low,medium and high risk cut-off points were distinguished by the ROC curve.Results:The family economy condition,eating bean product,releasing negative emotion,work intensity and screening breast cancer were the main risk factors of breast cancer(P <0.05 to P <0.01).The risk model showed that the women with P ≤ 0.49,0.49 <P <0.51 and P ≥ 0.51 were low,medium and high risk populations,respectively.Conclusions:The model can assess the probability of breast cancer in Bengbu women with specific risk factor,and provide certain basis in establishing the screening criteria.
2017, 42(4): 511-514.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.028
Abstract:
Objective:To evaluate the effects of the comprehensive intervention of human immunodeficiency virus(HIV) in men who have sex with men(MSM),and analyze its influencing factors of the high-risk behavior.Methods:Four hundred and thirteen MSM volunteers were intervened with the comprehensive intervention measures.The questionnaire,HIV antibody and syphilis were investigated and analyzed before and after the intervention,and the effect of the intervention was evaluated.Results:Compared with before intervention,the cognition rate about AIDS in MSM crowd increased significantly from 87.9% to 96.0% after intervention(P<0.01).After the comprehensive intervention,the condom use rates in the last time sexual behavior,last six months sexual behavior and last six months commercial sexual behavior significantly increased in MSM population(P <0.05 to P <0.01).The condom use rate in the sexual behavior of MSM population with female also increased significantly(P<0.01).Logistic regression analysis showed that age,marital status,education,knowledge related to AIDS and intervention service had a significant effect on the condom use of last six months sexual behavior among MSM population(P<0.05).Conclusions:The AIDS knowledge,self-protection awareness and condom use rate among MSM are significantly increased after comprehensive interventions,but the luck in some MSM population still exists,and the condom use rate does not arrive at 100%.How to strengthen risk awareness in this population is the focus of research.
Objective:To evaluate the effects of the comprehensive intervention of human immunodeficiency virus(HIV) in men who have sex with men(MSM),and analyze its influencing factors of the high-risk behavior.Methods:Four hundred and thirteen MSM volunteers were intervened with the comprehensive intervention measures.The questionnaire,HIV antibody and syphilis were investigated and analyzed before and after the intervention,and the effect of the intervention was evaluated.Results:Compared with before intervention,the cognition rate about AIDS in MSM crowd increased significantly from 87.9% to 96.0% after intervention(P<0.01).After the comprehensive intervention,the condom use rates in the last time sexual behavior,last six months sexual behavior and last six months commercial sexual behavior significantly increased in MSM population(P <0.05 to P <0.01).The condom use rate in the sexual behavior of MSM population with female also increased significantly(P<0.01).Logistic regression analysis showed that age,marital status,education,knowledge related to AIDS and intervention service had a significant effect on the condom use of last six months sexual behavior among MSM population(P<0.05).Conclusions:The AIDS knowledge,self-protection awareness and condom use rate among MSM are significantly increased after comprehensive interventions,but the luck in some MSM population still exists,and the condom use rate does not arrive at 100%.How to strengthen risk awareness in this population is the focus of research.
2017, 42(4): 515-517.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.029
Abstract:
Objective:To investigate the value between three-dimensional real-time echocardiography(RT-3DE) and magnetic resonance imaging(MRI) in the assessment of right ventricular function of patients with chronic obstructive pulmonary disease(COPD).Methods:The hearts of 26 patients with COPD were detected by RT-3DE and MRI.The image data were collected using RT-3DE full-volume imaging capture to contract three dimensional model of right ventricular for measuring the mean of the end-diastolic volume(EDV),end-systolic volume(ESV),stroke volume(SV) and ejection fraction(EF).Meanwhile,the four indexes of right ventricular function were measured using MRI several breath-hold cine.Results:The means of EDV,ESV,SV and EF measured by echocardiography were(118.35±13.83) mL,(66.74±14.27)mL,(49.16±12.38)mL and(45.1±6.7)%,respectively,the means of EDV,ESV,SV and EF measured by MRI were(124.63±21.52)mL,(62.18±12.34)mL,(51.25±15.83)mL and(46.3±7.1)%,respectively.The differences of four indexes measured by two kinds of methods were not statistically significant(P>0.05),which was no correlation between 2 methods(P>0.05).Conclusions:The RT-3DE in evaluating the right ventricular function in COPD patient is accurate and reliable,which is high correlation with the indexes measured by MRI.
Objective:To investigate the value between three-dimensional real-time echocardiography(RT-3DE) and magnetic resonance imaging(MRI) in the assessment of right ventricular function of patients with chronic obstructive pulmonary disease(COPD).Methods:The hearts of 26 patients with COPD were detected by RT-3DE and MRI.The image data were collected using RT-3DE full-volume imaging capture to contract three dimensional model of right ventricular for measuring the mean of the end-diastolic volume(EDV),end-systolic volume(ESV),stroke volume(SV) and ejection fraction(EF).Meanwhile,the four indexes of right ventricular function were measured using MRI several breath-hold cine.Results:The means of EDV,ESV,SV and EF measured by echocardiography were(118.35±13.83) mL,(66.74±14.27)mL,(49.16±12.38)mL and(45.1±6.7)%,respectively,the means of EDV,ESV,SV and EF measured by MRI were(124.63±21.52)mL,(62.18±12.34)mL,(51.25±15.83)mL and(46.3±7.1)%,respectively.The differences of four indexes measured by two kinds of methods were not statistically significant(P>0.05),which was no correlation between 2 methods(P>0.05).Conclusions:The RT-3DE in evaluating the right ventricular function in COPD patient is accurate and reliable,which is high correlation with the indexes measured by MRI.
Diagnostic value of the prenatal ultrasound for fetal limb malformation within 14 weeks of pregnancy
2017, 42(4): 518-520.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.030
Abstract:
Objective:To investigate the diagnostic value of the prenatal ultrasound for fetal limb malformation within 14 weeks of pregnancy.Methods:One thousand nine hundred and seventy early pregnancy women from May 2013 to May 2015 were investigated.The pregnant women were examined using ultrasound at 14 weeks and 24 weeks of pregnancy,and the morphology,structure,posture and movement of fetuses were observed using the systematic continuous sequence approach.The newborn was regularly followed up,and the autopsy of the fetus corpse after induced labor was implemented.Results:The ultrasonography of all fetal limbs was clear.The limb malformation in 20 cases,missed diagnosis of fetal limb deformity in 9 cases and misdiagnosis of congenital clubfoot in 1 case were identified,and the detection rate of fetus limb malformation was 68.9%(20/29) in early pregnancy.The fetal limb deformity in 6 cases and correcting the misdiagnosis of early pregnancy in 1 case were found in the second detection,the detection rate of two times in fetus limb malformation was 89.7%(26/29).In the early pregnancy detection of fetal limb malformation,the fetal limb malformation complicated with nasal bone loss in 3 cases,neck hygroma in 3 cases,and nuchal translucency thickening and venous flow spectrum change in 37.9%(11/29) fetuses were found.Conclusions:Most severe fetal limb deformities can be diagnosed by ultrasonography in time,which can make a correct guidance to implement effective intrauterine treatment or induction of labor.
Objective:To investigate the diagnostic value of the prenatal ultrasound for fetal limb malformation within 14 weeks of pregnancy.Methods:One thousand nine hundred and seventy early pregnancy women from May 2013 to May 2015 were investigated.The pregnant women were examined using ultrasound at 14 weeks and 24 weeks of pregnancy,and the morphology,structure,posture and movement of fetuses were observed using the systematic continuous sequence approach.The newborn was regularly followed up,and the autopsy of the fetus corpse after induced labor was implemented.Results:The ultrasonography of all fetal limbs was clear.The limb malformation in 20 cases,missed diagnosis of fetal limb deformity in 9 cases and misdiagnosis of congenital clubfoot in 1 case were identified,and the detection rate of fetus limb malformation was 68.9%(20/29) in early pregnancy.The fetal limb deformity in 6 cases and correcting the misdiagnosis of early pregnancy in 1 case were found in the second detection,the detection rate of two times in fetus limb malformation was 89.7%(26/29).In the early pregnancy detection of fetal limb malformation,the fetal limb malformation complicated with nasal bone loss in 3 cases,neck hygroma in 3 cases,and nuchal translucency thickening and venous flow spectrum change in 37.9%(11/29) fetuses were found.Conclusions:Most severe fetal limb deformities can be diagnosed by ultrasonography in time,which can make a correct guidance to implement effective intrauterine treatment or induction of labor.
2017, 42(4): 521-524.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.031
Abstract:
Objective:To explore the willingness of engaging in the elderly volunteer service and nursing geriatric in nursing undergraduates,and its influencing factors for providing reference in improving the training of nursing geriatric personnel.Methods:Five hundred nursing undergraduates were selected using cluster sampling method.The willingness of engaging in the elderly volunteer service and nursing geriatric,promoting and hindering factors and type of engaging elderly volunteer service in nursing undergraduates were investigated using questionnaire.Results:The 74.6% of nursing undergraduates were willing to participate in the elderly volunteer service,and 40.4% of nursing undergraduates were willing to engage in the job of nursing geriatric.The willingness of communicating with geriatric and liking the nursing profession were the influencing factors of engaging in the elderly volunteer service and nursing geriatric(P<0.01).The top three elderly volunteer services were visiting geriatric,recreation activities and medical advisory service for geriatric,respectively.The interesting in volunteer activities,helping the poor,contributing to society,cognition and attitude to volunteer activities were the main influencing factors on promoting the elderly volunteer service.The experience of communicating with elderly,good prospect and attitude toward elderly were the main factors in promoting the job of nursing geriatric.Conclusions:The willingness of engaging in the volunteer service is higher than that of nursing geriatric in nursing undergraduates.Liking the nursing profession and willing to get along with older people are the main potential resources in engaging in the elderly volunteer service and nursing geriatric in nursing undergraduates.
Objective:To explore the willingness of engaging in the elderly volunteer service and nursing geriatric in nursing undergraduates,and its influencing factors for providing reference in improving the training of nursing geriatric personnel.Methods:Five hundred nursing undergraduates were selected using cluster sampling method.The willingness of engaging in the elderly volunteer service and nursing geriatric,promoting and hindering factors and type of engaging elderly volunteer service in nursing undergraduates were investigated using questionnaire.Results:The 74.6% of nursing undergraduates were willing to participate in the elderly volunteer service,and 40.4% of nursing undergraduates were willing to engage in the job of nursing geriatric.The willingness of communicating with geriatric and liking the nursing profession were the influencing factors of engaging in the elderly volunteer service and nursing geriatric(P<0.01).The top three elderly volunteer services were visiting geriatric,recreation activities and medical advisory service for geriatric,respectively.The interesting in volunteer activities,helping the poor,contributing to society,cognition and attitude to volunteer activities were the main influencing factors on promoting the elderly volunteer service.The experience of communicating with elderly,good prospect and attitude toward elderly were the main factors in promoting the job of nursing geriatric.Conclusions:The willingness of engaging in the volunteer service is higher than that of nursing geriatric in nursing undergraduates.Liking the nursing profession and willing to get along with older people are the main potential resources in engaging in the elderly volunteer service and nursing geriatric in nursing undergraduates.
2017, 42(4): 525-528.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.032
Abstract:
Objective:To explore the effects of the scene simulation and interactive subject-seminar teaching method on the communication ability of nurse-patient relationship in higher vocational nursing students.Methods:One hundred and two higher vocational nursing students were randomly divided into the observation group and control group(51 students each group).The traditional individual skill practice and assessment,and interactive subject-seminar teaching method were implemented in control group and observation group,respectively.The communication abilities of nurse-patient relationship in two groups were evaluated using the communication ability of nurse-patient relationship questionnaire.The influencing factors of the communication ability of nurse-patient relationship and application effect of the scene simulation and interactive subject-seminar teaching method on communication ability of nurse-patient relationship were analyzed.Results:The differences of the communication abilities of nurse-patient relationship in whether or not class cadre,whether or not often attending community activity,whether or not liking the nursing profession and whether or not engaging in the nursing work after graduation in vocational nursing students were statistically significant(P<0.01).Multivariate analysis showed that the communication ability of nurse-patient relationship in nursing students engaging in nursing work after graduation significantly increased(P<0.01).The differences of the each item score and total score of the communication ability of nurse-patient relationship before teaching intervention between two groups were not statistically significant(P>0.05).Except the common involvement and validating feeling items,the differences of the each item score and total score of the communication ability of nurse-patient relationship after teaching intervention between two groups were statistically significant(P <0.05 to P <0.01).Conclusions:Work engagement in nursing after graduation of the higher vocational nursing student plays the most important role in the communication ability of nurse-patient relationship.The scene simulation and interactive subject-seminar teaching method can help to improve the communication ability of nurse-patient relationship in higher vocational nursing students.
Objective:To explore the effects of the scene simulation and interactive subject-seminar teaching method on the communication ability of nurse-patient relationship in higher vocational nursing students.Methods:One hundred and two higher vocational nursing students were randomly divided into the observation group and control group(51 students each group).The traditional individual skill practice and assessment,and interactive subject-seminar teaching method were implemented in control group and observation group,respectively.The communication abilities of nurse-patient relationship in two groups were evaluated using the communication ability of nurse-patient relationship questionnaire.The influencing factors of the communication ability of nurse-patient relationship and application effect of the scene simulation and interactive subject-seminar teaching method on communication ability of nurse-patient relationship were analyzed.Results:The differences of the communication abilities of nurse-patient relationship in whether or not class cadre,whether or not often attending community activity,whether or not liking the nursing profession and whether or not engaging in the nursing work after graduation in vocational nursing students were statistically significant(P<0.01).Multivariate analysis showed that the communication ability of nurse-patient relationship in nursing students engaging in nursing work after graduation significantly increased(P<0.01).The differences of the each item score and total score of the communication ability of nurse-patient relationship before teaching intervention between two groups were not statistically significant(P>0.05).Except the common involvement and validating feeling items,the differences of the each item score and total score of the communication ability of nurse-patient relationship after teaching intervention between two groups were statistically significant(P <0.05 to P <0.01).Conclusions:Work engagement in nursing after graduation of the higher vocational nursing student plays the most important role in the communication ability of nurse-patient relationship.The scene simulation and interactive subject-seminar teaching method can help to improve the communication ability of nurse-patient relationship in higher vocational nursing students.
2017, 42(4): 529-531,535.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.033
Abstract:
Objective:To investigate the general abilities of nursing student in higher vocational colleges,and analyze its influencing factors.Methods:One hundred and sixty nursing students from a higher vocational college were investigated using a self-made questionnaire of General Ability Scale,the content of which included general situation and 7 dimensions,18 items general abilities,of nursing students.Results:The total score of the general ability of nursing student was (67.432±7.688).The scores of "working with and relating to others" and "applying design and creativity" were the highest(3.953±0.512) and lowest(3.565±0.656) among all dimensions,respectively.Except the score of "management and self-development ability" in boy was higher than that in girl(P<0.05),the differences of the scores of general ability and all dimensions in different gender nursing students were not statistically significant(P>0.05).Except the score of "working with and relating to others" in grade two students was significantly better than that in grade one students(P<0.05),the differences of the scores of general ability and all dimensions in different grade students were not statistically significant(P>0.05).The scores of "management and self-development ability","applying design and creativity" and general ability in nursing students served as class cadre previously were higher than those in nursing students nonserved as class cadre previously(P <0.05 to P <0.01).The differences of the scores of general ability and all dimensions in the only child or not were not statistically significant(P>0.05).Conclusions:The general ability of nursing students is above the average level,but the abilities of "applying design and creativity","writing" and "solving problems" are lack,which should be strengthened.
Objective:To investigate the general abilities of nursing student in higher vocational colleges,and analyze its influencing factors.Methods:One hundred and sixty nursing students from a higher vocational college were investigated using a self-made questionnaire of General Ability Scale,the content of which included general situation and 7 dimensions,18 items general abilities,of nursing students.Results:The total score of the general ability of nursing student was (67.432±7.688).The scores of "working with and relating to others" and "applying design and creativity" were the highest(3.953±0.512) and lowest(3.565±0.656) among all dimensions,respectively.Except the score of "management and self-development ability" in boy was higher than that in girl(P<0.05),the differences of the scores of general ability and all dimensions in different gender nursing students were not statistically significant(P>0.05).Except the score of "working with and relating to others" in grade two students was significantly better than that in grade one students(P<0.05),the differences of the scores of general ability and all dimensions in different grade students were not statistically significant(P>0.05).The scores of "management and self-development ability","applying design and creativity" and general ability in nursing students served as class cadre previously were higher than those in nursing students nonserved as class cadre previously(P <0.05 to P <0.01).The differences of the scores of general ability and all dimensions in the only child or not were not statistically significant(P>0.05).Conclusions:The general ability of nursing students is above the average level,but the abilities of "applying design and creativity","writing" and "solving problems" are lack,which should be strengthened.
2017, 42(4): 532-535.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.034
Abstract:
Objective:To investigate the effects of nursing intervention on the survival quality of the advanced malignant tumor patients.Methods:One hundred and ten patients with advanced malignant tumor from January 2011 to January 2015 was divided into the control group and intervention group according to the admission time(55 cases each group).The control group was nursed with the routine means,and the intervention group was nursed with the nursing intervention based on the routine nursing.The anxiety,depression,level of self-controlled for cancer pain and life quality in two groups were evaluated using the hospital anxiety and depression scale,barriers questionnaire,functional assessment of cancer therapy-general.Results:Before intervention,the differences of the scores of the anxiety,depression,cancer pain and quality of life between two groups were not statistically significant(P>0.05).After the nursing intervention,the scores of anxiety,depression,average and sever degree of cancer pain,and quality of life in intervention group were significantly better than those in control group(P <0.05~P <0.01).Conclusions:The suitable nursing intervention can effectively relieve the degree of anxiety and depression,and improve the self-control level of the cancer pain and life quality.
Objective:To investigate the effects of nursing intervention on the survival quality of the advanced malignant tumor patients.Methods:One hundred and ten patients with advanced malignant tumor from January 2011 to January 2015 was divided into the control group and intervention group according to the admission time(55 cases each group).The control group was nursed with the routine means,and the intervention group was nursed with the nursing intervention based on the routine nursing.The anxiety,depression,level of self-controlled for cancer pain and life quality in two groups were evaluated using the hospital anxiety and depression scale,barriers questionnaire,functional assessment of cancer therapy-general.Results:Before intervention,the differences of the scores of the anxiety,depression,cancer pain and quality of life between two groups were not statistically significant(P>0.05).After the nursing intervention,the scores of anxiety,depression,average and sever degree of cancer pain,and quality of life in intervention group were significantly better than those in control group(P <0.05~P <0.01).Conclusions:The suitable nursing intervention can effectively relieve the degree of anxiety and depression,and improve the self-control level of the cancer pain and life quality.
2017, 42(4): 536-539,542.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.035
Abstract:
Objective:To investigate the effects of community rehabilitation extension intervention on recovering social function and improving coping style in patients with depression.Methods:One hundred patients with depression were divided into the control group and intervention group according to the patient's community(50 cases each group).Two groups were treated with routine nursing.After discharge,the control group was followed up after 3 and 12 months,and the intervention group was treated with community rehabilitation extension nursing and regularly followed up for 12 months.The scores of HAMD,quality of life and coping style,and recurrence between two groups were compared.Results:The differences of the HAMD scores at admission and discharge between two groups were not statistically significant(P>0.05),and the HAMD scores in two groups at discharge were significantly lower than that at admission(P<0.01).After discharge,the HAMD scores in two groups gradually increased(P<0.01),and which in intervention group was significantly lower than that in control group(P<0.01).The difference of the recurrence rate after 3 months of discharge between two groups was not statistically significant(P>0.05),and the recurrence rate after 12 months of discharge in intervention group was lower than that in control group(P<0.05).After 12 months of discharge,the difference of the pain score between two groups was not statistically significant(P>0.05),the other 7 items scores in intervention group were higher than those in control group(P <0.05 to P <0.01).The differences of the positive and negative coping scores at admission between two groups were not statistically significant(P>0.05).After 12 months of discharge,the positive coping score and negative coping score in intervention group were significantly higher and lower than those in control group,respectively(P<0.01).Conclusions:The community rehabilitation extension intervention is beneficial to the improvement of the life quality and recovery of social function in patients with depression,can improve the way of coping with stress events,enhance the clinical efficacy and reduce the recurrence.
Objective:To investigate the effects of community rehabilitation extension intervention on recovering social function and improving coping style in patients with depression.Methods:One hundred patients with depression were divided into the control group and intervention group according to the patient's community(50 cases each group).Two groups were treated with routine nursing.After discharge,the control group was followed up after 3 and 12 months,and the intervention group was treated with community rehabilitation extension nursing and regularly followed up for 12 months.The scores of HAMD,quality of life and coping style,and recurrence between two groups were compared.Results:The differences of the HAMD scores at admission and discharge between two groups were not statistically significant(P>0.05),and the HAMD scores in two groups at discharge were significantly lower than that at admission(P<0.01).After discharge,the HAMD scores in two groups gradually increased(P<0.01),and which in intervention group was significantly lower than that in control group(P<0.01).The difference of the recurrence rate after 3 months of discharge between two groups was not statistically significant(P>0.05),and the recurrence rate after 12 months of discharge in intervention group was lower than that in control group(P<0.05).After 12 months of discharge,the difference of the pain score between two groups was not statistically significant(P>0.05),the other 7 items scores in intervention group were higher than those in control group(P <0.05 to P <0.01).The differences of the positive and negative coping scores at admission between two groups were not statistically significant(P>0.05).After 12 months of discharge,the positive coping score and negative coping score in intervention group were significantly higher and lower than those in control group,respectively(P<0.01).Conclusions:The community rehabilitation extension intervention is beneficial to the improvement of the life quality and recovery of social function in patients with depression,can improve the way of coping with stress events,enhance the clinical efficacy and reduce the recurrence.
Effect of the delivery ball exercise in later pregnancy on the stages of labor and pregnancy outcome
2017, 42(4): 540-542.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.036
Abstract:
Objective:To observe the effects of the delivery ball exercise in later pregnancy on the labor and pregnancy outcome.Methods:One hundred and twenty-two later pregnancy women were randomly divided into the observation group and control group(61 cases each group).The control group was timely antepartum examined and guided about delievery,and the observation group was trained using the delivery ball.The pain degree,delivery way,labor time,and incidence rates of postpartum hemorrhage and neonatal asphyxia between two groups were compared.Results:The pain relief degree in observation group was significantly lower than that in control group(P<0.01).The vaginal delievery rate in observation group was significantly higher than that in control group(P<0.05).The use rates of the pethidine,diazepam and oxytocin at intrapartum in observation group were lower than those in control group(P <0.05 to P <0.01).The first and second labor times in observation group were significantly shorter than those in control group(P<0.01).The incidence rates of postpartum hemorrhage and neonatal asphyxia in observation group were lower than those in control group(P<0.05).Conclusions:The delivery ball exercise can relieve pain,shorten the labor,promote natural childbirth and reduce the incidence rates of postpartum hemorrhage and neonatal asphyxia.
Objective:To observe the effects of the delivery ball exercise in later pregnancy on the labor and pregnancy outcome.Methods:One hundred and twenty-two later pregnancy women were randomly divided into the observation group and control group(61 cases each group).The control group was timely antepartum examined and guided about delievery,and the observation group was trained using the delivery ball.The pain degree,delivery way,labor time,and incidence rates of postpartum hemorrhage and neonatal asphyxia between two groups were compared.Results:The pain relief degree in observation group was significantly lower than that in control group(P<0.01).The vaginal delievery rate in observation group was significantly higher than that in control group(P<0.05).The use rates of the pethidine,diazepam and oxytocin at intrapartum in observation group were lower than those in control group(P <0.05 to P <0.01).The first and second labor times in observation group were significantly shorter than those in control group(P<0.01).The incidence rates of postpartum hemorrhage and neonatal asphyxia in observation group were lower than those in control group(P<0.05).Conclusions:The delivery ball exercise can relieve pain,shorten the labor,promote natural childbirth and reduce the incidence rates of postpartum hemorrhage and neonatal asphyxia.
2017, 42(4): 543-545.
doi: 10.13898/j.cnki.issn.1000-2200.2017.04.037
Abstract:
Objective:To investigate the effects of traditional Chinese medicine psychological nursing on improving the psychological state in patients with coronary heart disease(CHD).Methods:Sixty-four patients with CHD were randomly divided into the control group and observation group(32 cases each group).The control group and observation group were nursed with routine method and traditional Chinese medicine psychological nursing based on the routine method,respectively.The anxiety and depression status,and quality of life between two groups were compared before and after intervention.Results:After the intervention of traditional Chinese medicine psychological nursing,the scores of the anxiety and depression in observation group decreased compared with the control group(P<0.01),and the scores of physiology,psychology,social relationship and environment of the Hospital Anxiety and Depression Scale in observation group significantly increased compared with the control group(P<0.01).Conclusions:Traditional Chinese medicine psychological nursing can effectively improve the psychological state and life quality of patients with CHD.
Objective:To investigate the effects of traditional Chinese medicine psychological nursing on improving the psychological state in patients with coronary heart disease(CHD).Methods:Sixty-four patients with CHD were randomly divided into the control group and observation group(32 cases each group).The control group and observation group were nursed with routine method and traditional Chinese medicine psychological nursing based on the routine method,respectively.The anxiety and depression status,and quality of life between two groups were compared before and after intervention.Results:After the intervention of traditional Chinese medicine psychological nursing,the scores of the anxiety and depression in observation group decreased compared with the control group(P<0.01),and the scores of physiology,psychology,social relationship and environment of the Hospital Anxiety and Depression Scale in observation group significantly increased compared with the control group(P<0.01).Conclusions:Traditional Chinese medicine psychological nursing can effectively improve the psychological state and life quality of patients with CHD.
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