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2017 Vol. 42, No. 6
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2017, 42(6): 701-705.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.001
Abstract:
Objective: To investigate the protective effects of P2X7 receptor antagonist BBG against hypoxia/reoxygenation(H/R) injury of astrocytes in rat,and explore its mechanisms. Methods: The astrocytes from 10 newborn SD rats were primarily cultured,and divided into the control group,H/R group,BBG(50 nmol/L) + H/R group.The astrocytes viability was detected by MTT assay.Function of gap junction(GJ) of astrocytes was evaluated using fluorescent tracer technique.The expression levels of Cx43,Bax and Bcl-2 were detected by Western blotting.The astrocytes apoptosis was detected by Hoechst 33258 staining assay. Results: The results of MTT assay showed that the viability of rat astrocytes injured by H/R significantly decreased(P<0.01),and the viability of rat astrocytes injured by H/R significantly increased after pretreatment of 50 nmol/L BBG(P<0.01).The results of fluorescent tracer technique showed that the gap junction function of astrocytes exposed to H/R strenghened(P<0.01).The results of Western blotting showed that the expression levels of Cx43 and Bax/Bcl-2 increased(P<0.01).After pretreatment with 50 nmol/L BBG,the gap junction function of astrocytes exposed to H/R decreased(P<0.05),and the expression levels of Cx43 and Bax/Bcl-2 decreased(P<0.05).The Hoechst 33258 staining assay showed that the apoptosis rate of rat astrocytes exposed to H/R significantly increased(P<0.05),and the apoptosis rate of rat astrocytes exposed to H/R decreased after pretreatment with BBG(P<0.01). Conclusions: can protect the rat astrocytes injured by H/R,the mechanism of which may be involved in the inhibition of Cx43 gap junction.
Objective: To investigate the protective effects of P2X7 receptor antagonist BBG against hypoxia/reoxygenation(H/R) injury of astrocytes in rat,and explore its mechanisms. Methods: The astrocytes from 10 newborn SD rats were primarily cultured,and divided into the control group,H/R group,BBG(50 nmol/L) + H/R group.The astrocytes viability was detected by MTT assay.Function of gap junction(GJ) of astrocytes was evaluated using fluorescent tracer technique.The expression levels of Cx43,Bax and Bcl-2 were detected by Western blotting.The astrocytes apoptosis was detected by Hoechst 33258 staining assay. Results: The results of MTT assay showed that the viability of rat astrocytes injured by H/R significantly decreased(P<0.01),and the viability of rat astrocytes injured by H/R significantly increased after pretreatment of 50 nmol/L BBG(P<0.01).The results of fluorescent tracer technique showed that the gap junction function of astrocytes exposed to H/R strenghened(P<0.01).The results of Western blotting showed that the expression levels of Cx43 and Bax/Bcl-2 increased(P<0.01).After pretreatment with 50 nmol/L BBG,the gap junction function of astrocytes exposed to H/R decreased(P<0.05),and the expression levels of Cx43 and Bax/Bcl-2 decreased(P<0.05).The Hoechst 33258 staining assay showed that the apoptosis rate of rat astrocytes exposed to H/R significantly increased(P<0.05),and the apoptosis rate of rat astrocytes exposed to H/R decreased after pretreatment with BBG(P<0.01). Conclusions: can protect the rat astrocytes injured by H/R,the mechanism of which may be involved in the inhibition of Cx43 gap junction.
2017, 42(6): 705-709.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.002
Abstract:
Objective: To investigate the effects and mechanism of chloroquine(CQ) enhancing the chemotherapy sensitivity of breast cancer cells to tamoxifen(TAM). Methods: The MCF-7 cells(estrogen-receptor positive breast cancer cells) were divided into the control group,TAM group,CQ group and CQ+TAM group.The control group was cultured with culture medium(no adding drug),and other groups were cultured with corresponding drugs.The survival rate of cells was determined using MTT assay.The inhibiting effects of MCF-7 cells proliferation induced by low concentration CQ,TAM and CQ combined with TAM were observed using colony formation assay.The cell apoptosis rate was determined by propidium bromide staining.The related protein expressions were detected by Western blot. Results: The survival rates of cells in TAM group,CQ group and TAM+CQ group at 24 h,48 h and 72 h of treatment were significantly lower than that in control group(P<0.01).The survival rates of cells in TAM+CQ group at 24 h,48 h and 72 h of treatment were significantly lower than that in TAM group and CQ group(P<0.01),and the survival rate of cells in TAM group at 24 h of treatment was significantly lower than that in CQ group(P<0.05).The results of colony formation assay showed that the effect of low concentration CQ on inhibiting the MCF-7 cells colony formation was not obvious,but CQ could strengthen the inhibiting effect of TAM.The differences of the apoptosis rate of cells between four groups were statistically significant(P<0.01).The apoptosis rates of cells in TAM group,CQ group and TAM+CQ group were significantly higher than that in control group(P<0.01),and the apoptosis rate of cells in TAM+CQ group was significantly higher than that in TAM group and CQ group(P<0.01).The results of Western blot showed that the protein expressions of Beclin-1 and LC3Ⅱ in TAM group increased,and the protein expression of p62 decreased with the increasing of time.Compared with the control group,the expression of LC3Ⅱprotein in TAM group significantly increased,and the expression of p62 protein in TAM group increased.Compared with the TAM group,the protein expressions of LC3Ⅱ,Beclin-1 and p62 in CQ+TAM group increased,and the expression of Bcl-2 protein in CQ+TAM group decreased. Conclusions: CQ can strengthen the chemotherapy sensitivity of breast cancer cells to TAM,the mechanism may be involved in downregulating the expression of Bcl-2 and inhibiting the autophagy.
Objective: To investigate the effects and mechanism of chloroquine(CQ) enhancing the chemotherapy sensitivity of breast cancer cells to tamoxifen(TAM). Methods: The MCF-7 cells(estrogen-receptor positive breast cancer cells) were divided into the control group,TAM group,CQ group and CQ+TAM group.The control group was cultured with culture medium(no adding drug),and other groups were cultured with corresponding drugs.The survival rate of cells was determined using MTT assay.The inhibiting effects of MCF-7 cells proliferation induced by low concentration CQ,TAM and CQ combined with TAM were observed using colony formation assay.The cell apoptosis rate was determined by propidium bromide staining.The related protein expressions were detected by Western blot. Results: The survival rates of cells in TAM group,CQ group and TAM+CQ group at 24 h,48 h and 72 h of treatment were significantly lower than that in control group(P<0.01).The survival rates of cells in TAM+CQ group at 24 h,48 h and 72 h of treatment were significantly lower than that in TAM group and CQ group(P<0.01),and the survival rate of cells in TAM group at 24 h of treatment was significantly lower than that in CQ group(P<0.05).The results of colony formation assay showed that the effect of low concentration CQ on inhibiting the MCF-7 cells colony formation was not obvious,but CQ could strengthen the inhibiting effect of TAM.The differences of the apoptosis rate of cells between four groups were statistically significant(P<0.01).The apoptosis rates of cells in TAM group,CQ group and TAM+CQ group were significantly higher than that in control group(P<0.01),and the apoptosis rate of cells in TAM+CQ group was significantly higher than that in TAM group and CQ group(P<0.01).The results of Western blot showed that the protein expressions of Beclin-1 and LC3Ⅱ in TAM group increased,and the protein expression of p62 decreased with the increasing of time.Compared with the control group,the expression of LC3Ⅱprotein in TAM group significantly increased,and the expression of p62 protein in TAM group increased.Compared with the TAM group,the protein expressions of LC3Ⅱ,Beclin-1 and p62 in CQ+TAM group increased,and the expression of Bcl-2 protein in CQ+TAM group decreased. Conclusions: CQ can strengthen the chemotherapy sensitivity of breast cancer cells to TAM,the mechanism may be involved in downregulating the expression of Bcl-2 and inhibiting the autophagy.
2017, 42(6): 710-712.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.003
Abstract:
Objective: To investigate the effects of addition and subtraction Xiangsha Liujunzi Decoction on the levels of serum interleukin(IL)-2,IL-4 and IL-6 in mice with functional dyspepsia(FD). Methods: The FD model of mice was established by irregular diet and drinking acidification water,and randomly divided into the normal group,model group,Chinese medicine group,western medicine group and combination group.The general state of mice was observed,and the serum levels of IL-2,IL-4 and IL-6 in mice were measured. Results: The body mass in model group was lower than that in Western medicine group(P<0.05),which was significantly lower than that in control group,Chinese medicine group and combination group(P<0.01),and the body mass in western medicine group was significantly lower than that in combination group(P<0.01).The food consumption in model group was significantly lower than that in control group,western medicine group and Chinese medicine group(P<0.01).The food consumption in western medicine group was lower than that in Chinese medicine group(P<0.05),and significantly lower than that in combination group(P<0.01).Compared with the model group,the levels of IL-2,IL-4 and IL-6 in medication administration groups significantly decreased(P<0.01).Compared with the western medicine group,the slevels of IL-4 and IL-6 in Chinese medicine group and combination group significantly decreased(P<0.01).Compared with the Chinese medicine group,the slevels of IL-6 in combination group significantly decreased(P<0.01). Conclusions: The add and subtract Xiangshaliujunzitang can improve the immune ability so as to achieve the purpose of the treatment of functional dyspepsia.And its curative effect havea strong advantage over Motilium.But the combination of Chinese and Western medicine can give full play to their advantages to achieve better therapeutic purposes.
Objective: To investigate the effects of addition and subtraction Xiangsha Liujunzi Decoction on the levels of serum interleukin(IL)-2,IL-4 and IL-6 in mice with functional dyspepsia(FD). Methods: The FD model of mice was established by irregular diet and drinking acidification water,and randomly divided into the normal group,model group,Chinese medicine group,western medicine group and combination group.The general state of mice was observed,and the serum levels of IL-2,IL-4 and IL-6 in mice were measured. Results: The body mass in model group was lower than that in Western medicine group(P<0.05),which was significantly lower than that in control group,Chinese medicine group and combination group(P<0.01),and the body mass in western medicine group was significantly lower than that in combination group(P<0.01).The food consumption in model group was significantly lower than that in control group,western medicine group and Chinese medicine group(P<0.01).The food consumption in western medicine group was lower than that in Chinese medicine group(P<0.05),and significantly lower than that in combination group(P<0.01).Compared with the model group,the levels of IL-2,IL-4 and IL-6 in medication administration groups significantly decreased(P<0.01).Compared with the western medicine group,the slevels of IL-4 and IL-6 in Chinese medicine group and combination group significantly decreased(P<0.01).Compared with the Chinese medicine group,the slevels of IL-6 in combination group significantly decreased(P<0.01). Conclusions: The add and subtract Xiangshaliujunzitang can improve the immune ability so as to achieve the purpose of the treatment of functional dyspepsia.And its curative effect havea strong advantage over Motilium.But the combination of Chinese and Western medicine can give full play to their advantages to achieve better therapeutic purposes.
2017, 42(6): 716-719.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.005
Abstract:
Objective: To investigate the clinical application value of the combined detection of serum lactate dehydrogenase(LDH) and superoxide dismutase(SOD) in the diagnosis and treatment of lung cancer. Methods: Forty-five patients with locally advanced or metastatic lung cancer were investigated,and 45 healthy physical examination people were set as the control group.The serum levels of LDH and SOD in lung cancer patients and healthy people were detected using Beckman Coulter AU5800 automatic biochemistry analyzer,and the changes of LDH and SOD between before and after chemotherapy in lung cancer patients were evaluated. Results: Compared with healthy control group,the level of LDH and SOD in lung cancer patients increased and decreased,respectively,and the differences of those were statistically significant(P<0.01).In lung cancer patients,the serum LDH was negatively associated with serum albumin level(P<0.05);the serum SOD was negatively associated with tumor stage(P<0.01),and the serum SOD was positively associated with the serum albumin level(P<0.05).The serum levels of LDH and SOD in lung cancer patients were negatively correlated before treatment(P<0.05).After two cycles of chemotherapy,the effect of chemotherapy was both positively correlated with the decrease of LDH and increase of SOD(P<0.05). Conclusions: The combined monitoring of the serum levels of LDH and SOD in patients may have a certain clinical significance in the diagnosis,assessment and efficacy evaluation of lung cancer.
Objective: To investigate the clinical application value of the combined detection of serum lactate dehydrogenase(LDH) and superoxide dismutase(SOD) in the diagnosis and treatment of lung cancer. Methods: Forty-five patients with locally advanced or metastatic lung cancer were investigated,and 45 healthy physical examination people were set as the control group.The serum levels of LDH and SOD in lung cancer patients and healthy people were detected using Beckman Coulter AU5800 automatic biochemistry analyzer,and the changes of LDH and SOD between before and after chemotherapy in lung cancer patients were evaluated. Results: Compared with healthy control group,the level of LDH and SOD in lung cancer patients increased and decreased,respectively,and the differences of those were statistically significant(P<0.01).In lung cancer patients,the serum LDH was negatively associated with serum albumin level(P<0.05);the serum SOD was negatively associated with tumor stage(P<0.01),and the serum SOD was positively associated with the serum albumin level(P<0.05).The serum levels of LDH and SOD in lung cancer patients were negatively correlated before treatment(P<0.05).After two cycles of chemotherapy,the effect of chemotherapy was both positively correlated with the decrease of LDH and increase of SOD(P<0.05). Conclusions: The combined monitoring of the serum levels of LDH and SOD in patients may have a certain clinical significance in the diagnosis,assessment and efficacy evaluation of lung cancer.
2017, 42(6): 720-721,724.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.006
Abstract:
Objective: To explore the application value of different approaches in the reoperation of thyroid. Methods: The clinical data of 85 thyroid tumor patients treated with reoperation were retrospectively analyzed.The patients were divided into the middle approach group(38 cases,middle group) and lateral approach group(47 cases,lateral group) according to the surgical approach.The operation time,intraoperative blood loss and postoperative complications between two groups were compared. Results: The mean operative time in lateral group[(1.5±0.5)h] was significantly shorter than that in middle group[(2.0±0.5)h] (P<0.01).The blood loss in lateral group[(35.5±6.5)mL]was significantly less than that in middle group[(55.8±8.7)mL](P<0.01).The overall incidence of postoperative complications in lateral group(17.03%) was lower than that in middle group(39.47%)(P<0.05). Conclusions: Compared with the conventional middle approach,the lateral approach in the reoperation of thyroid tumor can help to shorten the operation time,and reduce the intraoperative blood loss and incidence of postoperative complications.
Objective: To explore the application value of different approaches in the reoperation of thyroid. Methods: The clinical data of 85 thyroid tumor patients treated with reoperation were retrospectively analyzed.The patients were divided into the middle approach group(38 cases,middle group) and lateral approach group(47 cases,lateral group) according to the surgical approach.The operation time,intraoperative blood loss and postoperative complications between two groups were compared. Results: The mean operative time in lateral group[(1.5±0.5)h] was significantly shorter than that in middle group[(2.0±0.5)h] (P<0.01).The blood loss in lateral group[(35.5±6.5)mL]was significantly less than that in middle group[(55.8±8.7)mL](P<0.01).The overall incidence of postoperative complications in lateral group(17.03%) was lower than that in middle group(39.47%)(P<0.05). Conclusions: Compared with the conventional middle approach,the lateral approach in the reoperation of thyroid tumor can help to shorten the operation time,and reduce the intraoperative blood loss and incidence of postoperative complications.
2017, 42(6): 722-724.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.007
Abstract:
Objective: To evaluate the safety and efficacy of the conventional absorbable suture and one-way barbed suture in retroperitoneal laparoscopic partial nephrectomy(LPN). Methods: Sixty renal cell carcinoma patients with stage T1N0M0 were treated with LPN.The kidney in observation group(30 cases) and control group(30 cases) were sutured with one-way barbed suture(V-LocTM) and conventional absorbable suture,respectively. Results: The warm ischemia time in observation group and control group were(19.3±3.9)min and(23.5±5.1)min,respectively,the difference of which was statistically significant(P<0.01).The differences of the operation time,postoperative hospital stay and incidence rate of complication between two groups were not statistically significant(P>0.05). Conclusions: The application of one-way barbed suture in retroperitoneal LPN can significantly reduce the suture and warm ischemia time of kidney,protect the kidney,and is high safety and efficacy.
Objective: To evaluate the safety and efficacy of the conventional absorbable suture and one-way barbed suture in retroperitoneal laparoscopic partial nephrectomy(LPN). Methods: Sixty renal cell carcinoma patients with stage T1N0M0 were treated with LPN.The kidney in observation group(30 cases) and control group(30 cases) were sutured with one-way barbed suture(V-LocTM) and conventional absorbable suture,respectively. Results: The warm ischemia time in observation group and control group were(19.3±3.9)min and(23.5±5.1)min,respectively,the difference of which was statistically significant(P<0.01).The differences of the operation time,postoperative hospital stay and incidence rate of complication between two groups were not statistically significant(P>0.05). Conclusions: The application of one-way barbed suture in retroperitoneal LPN can significantly reduce the suture and warm ischemia time of kidney,protect the kidney,and is high safety and efficacy.
2017, 42(6): 725-727,731.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.008
Abstract:
Objective: To investigate the level of serum interleukin-6(IL-6) in patients with stage 1 to 5 chronic kidney disease(CKD),its influencing factors,and correlation of IL-6 level with diabetes. Methods: A total of 57 patients with CKD were divided into the early CKD group[14 cases,glomerular filtration rate(GFR) ≥ 60 mL·min-1·(1.73 m2)-1] and late CKD group[43 cases,GFR <60 mL·min-1·(1.73 m2)-1].The levels of IL-6 in two groups were detected,and the correlation of which with general biochemistry indicators wss analyzed.Meanwhile,the patients were divided into the CKD complicated with diabetes group(20 cases) and CKD non-complicated with diabetes group(37 cases) according to the diabetes history,respectively,and the clinical data of two groups were analyzed. Results: The levels of serum IL-6,blood uric acid,serum brain natriuretic peptide and parathyroid hormone in early CKD group were significantly lower those in late CKD group,but the level of hemoglobin in early CKD group was significantly higher than that in late CKD group(P<0.05 to P<0.01).The level of serum IL-6 was positively correlated with urine albumin(P<0.05).The levels of glycosylated hemoglobin,IL-6 and urine albumin in CKD patients complicated with diabetes were significantly higher than those in CKD patients non-complicated with diabetes(P<0.05). Conclusions: There is a significant difference of serum IL-6 level in different stages CKD patients.Compared with the CKD patients non-complicated with diabetes,the IL-6 level in CKD patients complicated with diabetes significantly increases.The urine albumin plays an important role in the serum level of IL-6 in CKD patients.
Objective: To investigate the level of serum interleukin-6(IL-6) in patients with stage 1 to 5 chronic kidney disease(CKD),its influencing factors,and correlation of IL-6 level with diabetes. Methods: A total of 57 patients with CKD were divided into the early CKD group[14 cases,glomerular filtration rate(GFR) ≥ 60 mL·min-1·(1.73 m2)-1] and late CKD group[43 cases,GFR <60 mL·min-1·(1.73 m2)-1].The levels of IL-6 in two groups were detected,and the correlation of which with general biochemistry indicators wss analyzed.Meanwhile,the patients were divided into the CKD complicated with diabetes group(20 cases) and CKD non-complicated with diabetes group(37 cases) according to the diabetes history,respectively,and the clinical data of two groups were analyzed. Results: The levels of serum IL-6,blood uric acid,serum brain natriuretic peptide and parathyroid hormone in early CKD group were significantly lower those in late CKD group,but the level of hemoglobin in early CKD group was significantly higher than that in late CKD group(P<0.05 to P<0.01).The level of serum IL-6 was positively correlated with urine albumin(P<0.05).The levels of glycosylated hemoglobin,IL-6 and urine albumin in CKD patients complicated with diabetes were significantly higher than those in CKD patients non-complicated with diabetes(P<0.05). Conclusions: There is a significant difference of serum IL-6 level in different stages CKD patients.Compared with the CKD patients non-complicated with diabetes,the IL-6 level in CKD patients complicated with diabetes significantly increases.The urine albumin plays an important role in the serum level of IL-6 in CKD patients.
2017, 42(6): 728-731.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.009
Abstract:
Objective: To investigate the correlations between serum high-sensitivity C-reactive protein(hs-CRP),Cystatin C(CysC),apolipoprotein A(ApoA),lipoprotein(a)[Lp(a)] and global registry of acute coronary evects(GRACE) score in non ST-elevation acute coronary syndromes(NSTE-ACS) patients. Methods: One hundred and thirty patients with NSTE-ACS and 80 patients without NSTE-ACS were divided into the NSTE-ACS group and control group,respectively.The clinical data of patients were collected,the serum levels of hs-CRP,CysC,ApoA and Lp(a) were detected on the second day of admission,and the GRACE score was assessed.The NSTE-ACS patients were subdivided into the low risk group(GRACE score ≤ 99),middle risk group(140 ≥ GRACE score>99) and high risk group(GRACE score>140) according to the GRACE risk score. Results: The age,gender,creatinine,history of hypertension and diabetes,hs-CRP,Lp(a),CysC and GRACE score in NSTE-ACS group were higher than those in control group (P<0.05 to P<0.01),while the level of ApoA in NSTE-ACS group was significantly lower than that in control group(P<0.01).The differences of the coronary artery lesion between three groups were not statistically significant(P>0.05),while the differences of the coronary artery stenosis degree between three groups were statistically significant(P<0.05).The serum levels of hs-CRP and Lp(a) in middle risk group and high risk group were significantly higher than those in low risk group(P<0.01),but the serum levels of ApoA in middle risk group and high risk group were significantly lower than those in low risk group(P<0.01).The serum levels of Lp(a) and CysC in high risk group were significantly higher than those in middle risk group(P<0.01),the serum level of ApoA in high risk group was significantly lower than that in middle risk group(P<0.01),and the serum level of CysC in high risk group was significantly higherthan that in low risk group(P<0.01).The differences of the levels of hs-CRP,ApoA,Lp(a) and CysC in different coronary artery lesions and stenosis degrees were statistically significant(P<0.01).In three-vessel coronary artery lesions and severe stenosis or occlusion of coronary artery patients,the levels of hs-CRP,Lp(a) and CysC were the highest,and the level of ApoA was the lowest.In single-vessel coronary artery lesion and mild stenosis of coronary artery patients,the levels of hs-CRP,Lp(a) and CysC were the lowest,and the level of ApoA was the highest. Conclusions: The levels of hs-CRP,CysC,Lp(a) and ApoA are closely related to the GRACE score.The joint detection has important clinical reference values in the early risk stratification,prognosis assessment and diagnosis scheme.
Objective: To investigate the correlations between serum high-sensitivity C-reactive protein(hs-CRP),Cystatin C(CysC),apolipoprotein A(ApoA),lipoprotein(a)[Lp(a)] and global registry of acute coronary evects(GRACE) score in non ST-elevation acute coronary syndromes(NSTE-ACS) patients. Methods: One hundred and thirty patients with NSTE-ACS and 80 patients without NSTE-ACS were divided into the NSTE-ACS group and control group,respectively.The clinical data of patients were collected,the serum levels of hs-CRP,CysC,ApoA and Lp(a) were detected on the second day of admission,and the GRACE score was assessed.The NSTE-ACS patients were subdivided into the low risk group(GRACE score ≤ 99),middle risk group(140 ≥ GRACE score>99) and high risk group(GRACE score>140) according to the GRACE risk score. Results: The age,gender,creatinine,history of hypertension and diabetes,hs-CRP,Lp(a),CysC and GRACE score in NSTE-ACS group were higher than those in control group (P<0.05 to P<0.01),while the level of ApoA in NSTE-ACS group was significantly lower than that in control group(P<0.01).The differences of the coronary artery lesion between three groups were not statistically significant(P>0.05),while the differences of the coronary artery stenosis degree between three groups were statistically significant(P<0.05).The serum levels of hs-CRP and Lp(a) in middle risk group and high risk group were significantly higher than those in low risk group(P<0.01),but the serum levels of ApoA in middle risk group and high risk group were significantly lower than those in low risk group(P<0.01).The serum levels of Lp(a) and CysC in high risk group were significantly higher than those in middle risk group(P<0.01),the serum level of ApoA in high risk group was significantly lower than that in middle risk group(P<0.01),and the serum level of CysC in high risk group was significantly higherthan that in low risk group(P<0.01).The differences of the levels of hs-CRP,ApoA,Lp(a) and CysC in different coronary artery lesions and stenosis degrees were statistically significant(P<0.01).In three-vessel coronary artery lesions and severe stenosis or occlusion of coronary artery patients,the levels of hs-CRP,Lp(a) and CysC were the highest,and the level of ApoA was the lowest.In single-vessel coronary artery lesion and mild stenosis of coronary artery patients,the levels of hs-CRP,Lp(a) and CysC were the lowest,and the level of ApoA was the highest. Conclusions: The levels of hs-CRP,CysC,Lp(a) and ApoA are closely related to the GRACE score.The joint detection has important clinical reference values in the early risk stratification,prognosis assessment and diagnosis scheme.
2017, 42(6): 732-735.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.010
Abstract:
Objective: To explore the clinical value of serum procalsitonin(PCT) level in anti-infection treatment for acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods: One hundred and twenty patients with AECOPD were divided into the PCT group and conventional group according to the random number table(60 cases each group).The use of antibiotics in PCT group was adjusted according to the serum level of PCT(PCT ≥ 0.25 μg/L,use antibiotics,and PCT<0.25 μg/L,not use antibiotics),and the use of antibiotics in conventional group was adjusted according to the clinical symptoms of patients and clinical experience of doctors.The rate of antibiotics use,length of antibiotics use,length of hospital stay,clinical effective rate,double infection rate,recurrence rate within half a year,inflammatory indicators[including white blood cells(WBC),neutrophils,C-reactive protein (CRP)] and blood gas index were observed in two groups. Results: The rates of antibiotics use and double infection in PCT group were significantly lower than those in conventional group(P<0.01 and P<0.05),and the length of antibiotics use in PCT group was significantly shorter than that in the conventional group(P<0.01).Compared with the conventional group,the length of hospital stay in PCT group was significantly shorter(P<0.01).There were no statistical significances in clinical effective rate and recurrence rate within half a year between two groups(P>0.05).After treatment,there were no statistical significances in WBC count,neutrophils level,serum CRP level and blood gas index between two groups(P>0.05). Conclusions: According to the serum PCT level in anti-infection therapy of AECOPD patients,the antibiotics use can be effectively reduced,the length of hospitalization can be shortened,the double infection rate can be decreased,and the therapeutic effect can not be affected.
Objective: To explore the clinical value of serum procalsitonin(PCT) level in anti-infection treatment for acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods: One hundred and twenty patients with AECOPD were divided into the PCT group and conventional group according to the random number table(60 cases each group).The use of antibiotics in PCT group was adjusted according to the serum level of PCT(PCT ≥ 0.25 μg/L,use antibiotics,and PCT<0.25 μg/L,not use antibiotics),and the use of antibiotics in conventional group was adjusted according to the clinical symptoms of patients and clinical experience of doctors.The rate of antibiotics use,length of antibiotics use,length of hospital stay,clinical effective rate,double infection rate,recurrence rate within half a year,inflammatory indicators[including white blood cells(WBC),neutrophils,C-reactive protein (CRP)] and blood gas index were observed in two groups. Results: The rates of antibiotics use and double infection in PCT group were significantly lower than those in conventional group(P<0.01 and P<0.05),and the length of antibiotics use in PCT group was significantly shorter than that in the conventional group(P<0.01).Compared with the conventional group,the length of hospital stay in PCT group was significantly shorter(P<0.01).There were no statistical significances in clinical effective rate and recurrence rate within half a year between two groups(P>0.05).After treatment,there were no statistical significances in WBC count,neutrophils level,serum CRP level and blood gas index between two groups(P>0.05). Conclusions: According to the serum PCT level in anti-infection therapy of AECOPD patients,the antibiotics use can be effectively reduced,the length of hospitalization can be shortened,the double infection rate can be decreased,and the therapeutic effect can not be affected.
2017, 42(6): 736-737.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.011
Abstract:
Objective: To investigate the risk factors of the multiple organ dysfunction syndrome(MODS) in patients with cerebral hemorrhage coma for providing a reference in clinical treatment. Methods: Eighty-eight patients with cerebral hemorrhage coma were divided into group A(48 cases with MODS) and group B(40 cases without MODS).The levels of interleukin(IL) -1 and IL-10 in two groups were detected.The scores of the Glasgow Coma Scale,acute physiology and chronic health evaluation(APACHE-Ⅱ) in two groups were measured,and the risk factors of MODS were analyzed. Results: The levels of IL-1 and IL-10,APACHE-Ⅱ score,cerebral hemorrhage amount,blood glucose level and other indicators in group A were higher than those in group B(P<0.05 to P<0.01),and the score of Glasgow Coma Scale in group A was lower than that in group B(P<0.01).The APACHE-Ⅱ score,IL-10,blood glucose levels,and cerebral hemorrhage amount were the main risk factors of MODS(P<0.05 to P<0.01). Conclusions: The cerebral hemorrhage amount,IL-10 level,APACHE-Ⅱ score,and high blood glucose are the main risk factors of MODS in cerebral hemorrhage patients.
Objective: To investigate the risk factors of the multiple organ dysfunction syndrome(MODS) in patients with cerebral hemorrhage coma for providing a reference in clinical treatment. Methods: Eighty-eight patients with cerebral hemorrhage coma were divided into group A(48 cases with MODS) and group B(40 cases without MODS).The levels of interleukin(IL) -1 and IL-10 in two groups were detected.The scores of the Glasgow Coma Scale,acute physiology and chronic health evaluation(APACHE-Ⅱ) in two groups were measured,and the risk factors of MODS were analyzed. Results: The levels of IL-1 and IL-10,APACHE-Ⅱ score,cerebral hemorrhage amount,blood glucose level and other indicators in group A were higher than those in group B(P<0.05 to P<0.01),and the score of Glasgow Coma Scale in group A was lower than that in group B(P<0.01).The APACHE-Ⅱ score,IL-10,blood glucose levels,and cerebral hemorrhage amount were the main risk factors of MODS(P<0.05 to P<0.01). Conclusions: The cerebral hemorrhage amount,IL-10 level,APACHE-Ⅱ score,and high blood glucose are the main risk factors of MODS in cerebral hemorrhage patients.
2017, 42(6): 738-739,742.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.012
Abstract:
Objective: To investigate the predictive effects of the KDIGO criteria in the related kidney damage risk induced by contrast agents in severe patients. Methods: Four hundred and ninty patients with the history of intracranial artery interventional examination and therapy from May 2013 to January 2015 were selected.The diagnosis in the patients was evaluated using the KDIGO criteria and RIFLE criteria,and the difference between two diagnostic methods was compared. Results: Low permeability contrast agent was used,the evaluation of KDIGO and RIFLE diagnostic criteria showed that the acute kidney injury in 132 cases(26.94%) and 89 cases(18.16%) were identified,respectively.The average hospitalization time in 132 cases diagnosed by KDIGO criteria and 89 cases(death in 5 cases) diagnosed by RIFLE criteria were(10.15 ±2.30)and(9.23 ±1.95) days,respectively.The average hospitalization time in the patients detected by KDIGO criteria,but not by RIFLE criteria detection was(14.01±3.10) days.ROC curve anglysis shows that the area under the curve of the KDIGO standard is greater than the RIFLE standard and has a higher diagnosetic value. Conclusions: Compared with the RIFLE criteria,the KDIGO criteria can diagnose more patients with acute kidney injury more sensitively,which is beneficial to the diagnosis and treatment,and worthy of clinical application.
Objective: To investigate the predictive effects of the KDIGO criteria in the related kidney damage risk induced by contrast agents in severe patients. Methods: Four hundred and ninty patients with the history of intracranial artery interventional examination and therapy from May 2013 to January 2015 were selected.The diagnosis in the patients was evaluated using the KDIGO criteria and RIFLE criteria,and the difference between two diagnostic methods was compared. Results: Low permeability contrast agent was used,the evaluation of KDIGO and RIFLE diagnostic criteria showed that the acute kidney injury in 132 cases(26.94%) and 89 cases(18.16%) were identified,respectively.The average hospitalization time in 132 cases diagnosed by KDIGO criteria and 89 cases(death in 5 cases) diagnosed by RIFLE criteria were(10.15 ±2.30)and(9.23 ±1.95) days,respectively.The average hospitalization time in the patients detected by KDIGO criteria,but not by RIFLE criteria detection was(14.01±3.10) days.ROC curve anglysis shows that the area under the curve of the KDIGO standard is greater than the RIFLE standard and has a higher diagnosetic value. Conclusions: Compared with the RIFLE criteria,the KDIGO criteria can diagnose more patients with acute kidney injury more sensitively,which is beneficial to the diagnosis and treatment,and worthy of clinical application.
2017, 42(6): 740-742.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.013
Abstract:
Objective: To investigate the clinical effects of enalapril maleate-folate tablet in the treatment of H-hypertension. Methods: One hundred and sixty patients with H-hypertension were randomly divided into the observation group and control group(80 cases in each group).The control group was treated with enalapril maleate tablet,and the observation group was treated with enalapril maleate-folate tablet.The levels of homocysteine(Hcy) and blood pressure in two groups between before and after treatment were compared. Results: After treatment,the total effective rate in observation group(96.3%) was significantly higher than that in control group(87.5%)(P<0.05).Before treatment,the differences of the levels of Hcy,systolic blood pressure(SBP) and diastolic blood pressure(DBP) between two groups were not statistically significant(P>0.05).Compared with before treatment,the levels of Hcy,SBP and DBP in two groups decreased after treatment,the decreasing degree of which in observation group was more obvious,and the difference of which between two groups was statistically significant(P<0.01).The difference of the incidence rate of adverse reactions between two groups was not statistically significant(P>0.05).The cerebrovascular event in two groups was not found. Conclusions: Compared with enalapril maleate tablet,the effect of enalapril maleate-folate tablet in treating H-hypertension is obvious,which can significantly improve the serum level of Hcy,and is worthy of clinical promotion.
Objective: To investigate the clinical effects of enalapril maleate-folate tablet in the treatment of H-hypertension. Methods: One hundred and sixty patients with H-hypertension were randomly divided into the observation group and control group(80 cases in each group).The control group was treated with enalapril maleate tablet,and the observation group was treated with enalapril maleate-folate tablet.The levels of homocysteine(Hcy) and blood pressure in two groups between before and after treatment were compared. Results: After treatment,the total effective rate in observation group(96.3%) was significantly higher than that in control group(87.5%)(P<0.05).Before treatment,the differences of the levels of Hcy,systolic blood pressure(SBP) and diastolic blood pressure(DBP) between two groups were not statistically significant(P>0.05).Compared with before treatment,the levels of Hcy,SBP and DBP in two groups decreased after treatment,the decreasing degree of which in observation group was more obvious,and the difference of which between two groups was statistically significant(P<0.01).The difference of the incidence rate of adverse reactions between two groups was not statistically significant(P>0.05).The cerebrovascular event in two groups was not found. Conclusions: Compared with enalapril maleate tablet,the effect of enalapril maleate-folate tablet in treating H-hypertension is obvious,which can significantly improve the serum level of Hcy,and is worthy of clinical promotion.
2017, 42(6): 743-746,749.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.014
Abstract:
Objective: To investigate the clinical effects of mosapride combined with rabeprazole sodium enteric-coated tablet in the treatment of senile reflux esophagitis(RE). Methods: Seventy-eight elderly patients with RE were randomly divided into the control group and observation group(39 cases each group).The control group was treated with 20 mg of rabeprazole sodium enteric-coated tablet each time,one tablet a day,and the observation group was treated with 5 mg of mosapride each time,3 times a day,based on the control group for 8 weeks.The serum levels of gastrointestinal hormones[gastrin(GAS),motilin(MTL) and vasoactive intestinal peptide(VIP)] and cytokines,and 24 h pH value of esophagus were measured,and the score of typical RE symptom was evaluated.The clinical effect between two groups was compared. Results: Compared with before treatment,the serum levels of GAS and MTL in two groups increased (P<0.01),and the serum levels of VIP,IL-6,IL-8 and TNF-α in two groups decreased after treatment(P<0.01).Compared with before treatment,the number of reflux(pH<4),reflux frequency(reflux duration ≥ 5 min),longest reflux duration time(pH<4),total time(pH<4)and percentage of time(pH<4) in two groups decreased after treatment(P<0.01).Compared with before treatment,the scores of the typical RE symptoms(heartburn,acid reflux and retrosternal burning pain) in two groups decreased after treatment(P<0.01).Compared with the control group,the levels of MTL and GAS in observation group were higher(P<0.01),the levels of VIP,IL-6,IL-8 and TNF-α in observation group were lower(P<0.01).Compared with the control group,the number of reflux(pH<4) and reflux frequency(reflux duration ≥ 5 min),longest reflux duration time(pH<4),total time(pH<4)and percentage of time(pH<4) in observation group were lower(P<0.01).Compared with the control group,the scores of the typical RE symptoms(heartburn,acid reflux,substernal burning pain) in observation group were lower(P<0.01),and the total effective rate in observation group was higher(P<0.05). Conclusions: The clinical effect of mosapride combined with rabeprazole sodium enteric-coated tablet in the treatment of senile RE is good,which may be associated with the regulation of factrs such as MTL,IL-6, TNF-α and so on.
Objective: To investigate the clinical effects of mosapride combined with rabeprazole sodium enteric-coated tablet in the treatment of senile reflux esophagitis(RE). Methods: Seventy-eight elderly patients with RE were randomly divided into the control group and observation group(39 cases each group).The control group was treated with 20 mg of rabeprazole sodium enteric-coated tablet each time,one tablet a day,and the observation group was treated with 5 mg of mosapride each time,3 times a day,based on the control group for 8 weeks.The serum levels of gastrointestinal hormones[gastrin(GAS),motilin(MTL) and vasoactive intestinal peptide(VIP)] and cytokines,and 24 h pH value of esophagus were measured,and the score of typical RE symptom was evaluated.The clinical effect between two groups was compared. Results: Compared with before treatment,the serum levels of GAS and MTL in two groups increased (P<0.01),and the serum levels of VIP,IL-6,IL-8 and TNF-α in two groups decreased after treatment(P<0.01).Compared with before treatment,the number of reflux(pH<4),reflux frequency(reflux duration ≥ 5 min),longest reflux duration time(pH<4),total time(pH<4)and percentage of time(pH<4) in two groups decreased after treatment(P<0.01).Compared with before treatment,the scores of the typical RE symptoms(heartburn,acid reflux and retrosternal burning pain) in two groups decreased after treatment(P<0.01).Compared with the control group,the levels of MTL and GAS in observation group were higher(P<0.01),the levels of VIP,IL-6,IL-8 and TNF-α in observation group were lower(P<0.01).Compared with the control group,the number of reflux(pH<4) and reflux frequency(reflux duration ≥ 5 min),longest reflux duration time(pH<4),total time(pH<4)and percentage of time(pH<4) in observation group were lower(P<0.01).Compared with the control group,the scores of the typical RE symptoms(heartburn,acid reflux,substernal burning pain) in observation group were lower(P<0.01),and the total effective rate in observation group was higher(P<0.05). Conclusions: The clinical effect of mosapride combined with rabeprazole sodium enteric-coated tablet in the treatment of senile RE is good,which may be associated with the regulation of factrs such as MTL,IL-6, TNF-α and so on.
2017, 42(6): 747-749.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.015
Abstract:
Objective: To observe the clinical efficacy of phacoemulsification combined with intraocular lens implantation in the treatment of angle-closure glaucoma(ACG) complicated with cataract. Methods: Forty-seven patients(56 eyes) with acute ACG complicated with cataract(the closing range of anterior chamber angle smaller than 180°) were treated with phacoemulsification combined with intraocular lens implantation.The intraocular pressure,depth of anterior chamber,anterior chamber angle and corrected vision in all cases between before and after operation were compared,and all patients were followed up for 6 months. Results: Compared with before operation,the best corrected vision,intraocular pressure,depth of anterior chamber and anterior chamber open angle in all cases were significantly improved after operation(P<0.01). Conclusions: The effect of phacoemulsification combined with intraocular lens implantation in treating the ACG complicated with cataract is good.
Objective: To observe the clinical efficacy of phacoemulsification combined with intraocular lens implantation in the treatment of angle-closure glaucoma(ACG) complicated with cataract. Methods: Forty-seven patients(56 eyes) with acute ACG complicated with cataract(the closing range of anterior chamber angle smaller than 180°) were treated with phacoemulsification combined with intraocular lens implantation.The intraocular pressure,depth of anterior chamber,anterior chamber angle and corrected vision in all cases between before and after operation were compared,and all patients were followed up for 6 months. Results: Compared with before operation,the best corrected vision,intraocular pressure,depth of anterior chamber and anterior chamber open angle in all cases were significantly improved after operation(P<0.01). Conclusions: The effect of phacoemulsification combined with intraocular lens implantation in treating the ACG complicated with cataract is good.
2017, 42(6): 750-751,754.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.016
Abstract:
Objective: To observe the effects of the intraperitoneal cytokine-induced-killer(CIK) cell combined with immunomodulator in the treatment of malignant ascites. Methods: Fifty middle and advanced stage patients with liver,stomach and pancreas complicated with ascites were randomly divided into the DDP(cisplatin) group and CIK group(25 cases each group).The DDP group were treated with intraperitoneal DPP chemotherapy,and the CIK group were treated with CIK cell therapy combined with mannatide immunity regulating,twice a week for 8 times.The efficacy,adverse reaction and Karnofsky Performance Status(KPS) score between two groups were compared. Results: The total effective rate in CIK group(76.0%) was significantly higher than that in DDP group(40.0%)(P<0.01).The gastrointestinal disorder and bone marrow suppression were the main adverse reactions in DDP group.Except a case with transient body temperature increasing,no adverse reaction was found in CIK group.The improvement of white blood cells,albumin,appetite and KPS score in CIK group were significantly better than those in DDP group(P<0.01). Conclusions: The intraperitoneal CIK cell therapy can control the malignant ascites and improve the symptom of patients,which is little adverse reaction,and worthy of promotion in clinic.
Objective: To observe the effects of the intraperitoneal cytokine-induced-killer(CIK) cell combined with immunomodulator in the treatment of malignant ascites. Methods: Fifty middle and advanced stage patients with liver,stomach and pancreas complicated with ascites were randomly divided into the DDP(cisplatin) group and CIK group(25 cases each group).The DDP group were treated with intraperitoneal DPP chemotherapy,and the CIK group were treated with CIK cell therapy combined with mannatide immunity regulating,twice a week for 8 times.The efficacy,adverse reaction and Karnofsky Performance Status(KPS) score between two groups were compared. Results: The total effective rate in CIK group(76.0%) was significantly higher than that in DDP group(40.0%)(P<0.01).The gastrointestinal disorder and bone marrow suppression were the main adverse reactions in DDP group.Except a case with transient body temperature increasing,no adverse reaction was found in CIK group.The improvement of white blood cells,albumin,appetite and KPS score in CIK group were significantly better than those in DDP group(P<0.01). Conclusions: The intraperitoneal CIK cell therapy can control the malignant ascites and improve the symptom of patients,which is little adverse reaction,and worthy of promotion in clinic.
2017, 42(6): 752-754.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.017
Abstract:
Objective: To investigate the changes of peripheral blood natural killer(NK) cell between inevitable abortion and successful pregnancy in patients with unexplained recurrent spontaneous abortion(URSA),and its clinical significance. Methods: Forty-four URSA abortion patients and 34 URSA pregnant patients were divided into the URSA abortion group and URSA pregnancy group,respectively.Forty-four normal pregnancy women and 44 normal non-pregnancy women were divided into the normal pregnancy group and normal non-pregnancy group(control group),respectively.The number of peripheral blood NK cells in four groups was detected using flow cytometry. Results: The ratio of NK cell to lymphocyte in URSA abortion group,URSA pregnancy group,normal pregnancy group and normal non-pregnancy group was(21.18±5.81)%,(16.12±4.13)%,(15.16±3.23)% and(14.91±3.18)%,respectively.The ratio of NK cell to lymphocyte in URSA abortion group was higher than that in URSA pregnancy group,normal pregnancy group and normal non-pregnancy group(P<0.01),the differences of which between URSA pregnancy group,normal pregnancy group and normal non-pregnancy group were not statistically significant(P>0.05). Conclusions: The occurrence of URSA may be associated with the enhancement of NK cells to embryo Rilling.The number of NK cells in peripheral blood can be used as an index in monitoring URSA patients.
Objective: To investigate the changes of peripheral blood natural killer(NK) cell between inevitable abortion and successful pregnancy in patients with unexplained recurrent spontaneous abortion(URSA),and its clinical significance. Methods: Forty-four URSA abortion patients and 34 URSA pregnant patients were divided into the URSA abortion group and URSA pregnancy group,respectively.Forty-four normal pregnancy women and 44 normal non-pregnancy women were divided into the normal pregnancy group and normal non-pregnancy group(control group),respectively.The number of peripheral blood NK cells in four groups was detected using flow cytometry. Results: The ratio of NK cell to lymphocyte in URSA abortion group,URSA pregnancy group,normal pregnancy group and normal non-pregnancy group was(21.18±5.81)%,(16.12±4.13)%,(15.16±3.23)% and(14.91±3.18)%,respectively.The ratio of NK cell to lymphocyte in URSA abortion group was higher than that in URSA pregnancy group,normal pregnancy group and normal non-pregnancy group(P<0.01),the differences of which between URSA pregnancy group,normal pregnancy group and normal non-pregnancy group were not statistically significant(P>0.05). Conclusions: The occurrence of URSA may be associated with the enhancement of NK cells to embryo Rilling.The number of NK cells in peripheral blood can be used as an index in monitoring URSA patients.
2017, 42(6): 755-757,760.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.018
Abstract:
Objective: To investigate the clinical effects of injection pulmonary surfactant(PS)using modified method in the treatment of endogenous and exogenous acute lung injury of newborns. Methods: Seventy-two newborns with endogenous or exogenous acute lung injury were randomly divided into the observation group and control group according to random number table(36 cases each group).The control group and observation group were injected with PS using traditional and modified method,respectively.The non-invasive percutaneous oxygen saturation,which included arterial oxygen partial pressure(PaO2) and arterial carbon dioxide partial pressure(PaCO2),in two groups were determined before and after treatment.The clinical efficacy of two groups was evaluated.The ventilation time,oxygen treatment time,hospitalization time and complications in two groups were observed. Results: The effective rate in treatment group(97.2%) was higher than that in control group(83.3%)(P<0.01).Compared with the control group,the differences of the changes of PaO2 and PaCO2 value in observation group were statistically significant(P<0.01).The ventilation time,duration of oxygen therapy and hospitalization time in observation group were less than those in control group(P<0.01).The incidence rates of pneumothorax,apnea,lung infection in observation group were less than those in control group(P<0.05 to P<0.01). Conclusions: The injection PS using modified method in treating endogenous and exogenous acute lung injury of newborns can effectively improve the blood indicators,reduce complications,increase the overall effect and promote the rehabilitation of children.
Objective: To investigate the clinical effects of injection pulmonary surfactant(PS)using modified method in the treatment of endogenous and exogenous acute lung injury of newborns. Methods: Seventy-two newborns with endogenous or exogenous acute lung injury were randomly divided into the observation group and control group according to random number table(36 cases each group).The control group and observation group were injected with PS using traditional and modified method,respectively.The non-invasive percutaneous oxygen saturation,which included arterial oxygen partial pressure(PaO2) and arterial carbon dioxide partial pressure(PaCO2),in two groups were determined before and after treatment.The clinical efficacy of two groups was evaluated.The ventilation time,oxygen treatment time,hospitalization time and complications in two groups were observed. Results: The effective rate in treatment group(97.2%) was higher than that in control group(83.3%)(P<0.01).Compared with the control group,the differences of the changes of PaO2 and PaCO2 value in observation group were statistically significant(P<0.01).The ventilation time,duration of oxygen therapy and hospitalization time in observation group were less than those in control group(P<0.01).The incidence rates of pneumothorax,apnea,lung infection in observation group were less than those in control group(P<0.05 to P<0.01). Conclusions: The injection PS using modified method in treating endogenous and exogenous acute lung injury of newborns can effectively improve the blood indicators,reduce complications,increase the overall effect and promote the rehabilitation of children.
2017, 42(6): 758-760.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.019
Abstract:
Objective: To investigate the effects of the tumor specific growth factor(TSGF) and hepatocyte growth factor(HGF) on the progress of brain glioma,and relationship between TSGF,HGF and neovascularization factor. Methods: Eighty-seven glioma patients(including 29 cases of WHO grade Ⅰ,26 cases of WHO grade Ⅱ,21 cases of WHO grade Ⅲ and 11 cases of WHO grade Ⅳ) were investigated.The levels of TSGF,HGF,epidermal growth factor(EGF),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and angiopoietin 1(Ang-1) in cerebrospinal fluid of all patients were detected. Results: Compared with gradeⅠpatients,the levels of TSGF and HGF in grade Ⅱpatients significantly increased(P<0.01).Compared with gradeⅠ and grade Ⅱ patients,the levels of TSGF and HGF in grade Ⅲ patients significantly increased(P<0.01).Compared with gradeⅠ,grade Ⅱ and gradeⅢ patients,the levels of TSGF and HGF in grade Ⅳ patients significantly increased(P<0.01).Compared with gradeⅠpatients,the level of VEGF in grade Ⅱpatients significantly increased(P<0.01).Compared with gradeⅠ and grade Ⅱ patients,the level of VEGF in grade Ⅲ patients significantly increased(P<0.01).Compared with gradeⅠand Ⅱpatients,the levels of bFGF and Ang-1 in grade Ⅲ and Ⅳ patients significantly increased(P<0.01).Compared with gradeⅠ,grade Ⅱ and grade Ⅲ patients,the level of VEGF in grade Ⅳ patients significantly increased(P<0.01).The level of TSGF was positively correlated with the levels of VEGF,bFGF and Ang-1(P<0.05 to P<0.01),and the level of HGF was positively correlated with the level of VEGF(P<0.01). Conclusions: The increasing level of HGF and TSGF in cerebrospinal fluid is an important factor in glioma progress,which is closely related to the increasing of neovasculization factor.
Objective: To investigate the effects of the tumor specific growth factor(TSGF) and hepatocyte growth factor(HGF) on the progress of brain glioma,and relationship between TSGF,HGF and neovascularization factor. Methods: Eighty-seven glioma patients(including 29 cases of WHO grade Ⅰ,26 cases of WHO grade Ⅱ,21 cases of WHO grade Ⅲ and 11 cases of WHO grade Ⅳ) were investigated.The levels of TSGF,HGF,epidermal growth factor(EGF),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and angiopoietin 1(Ang-1) in cerebrospinal fluid of all patients were detected. Results: Compared with gradeⅠpatients,the levels of TSGF and HGF in grade Ⅱpatients significantly increased(P<0.01).Compared with gradeⅠ and grade Ⅱ patients,the levels of TSGF and HGF in grade Ⅲ patients significantly increased(P<0.01).Compared with gradeⅠ,grade Ⅱ and gradeⅢ patients,the levels of TSGF and HGF in grade Ⅳ patients significantly increased(P<0.01).Compared with gradeⅠpatients,the level of VEGF in grade Ⅱpatients significantly increased(P<0.01).Compared with gradeⅠ and grade Ⅱ patients,the level of VEGF in grade Ⅲ patients significantly increased(P<0.01).Compared with gradeⅠand Ⅱpatients,the levels of bFGF and Ang-1 in grade Ⅲ and Ⅳ patients significantly increased(P<0.01).Compared with gradeⅠ,grade Ⅱ and grade Ⅲ patients,the level of VEGF in grade Ⅳ patients significantly increased(P<0.01).The level of TSGF was positively correlated with the levels of VEGF,bFGF and Ang-1(P<0.05 to P<0.01),and the level of HGF was positively correlated with the level of VEGF(P<0.01). Conclusions: The increasing level of HGF and TSGF in cerebrospinal fluid is an important factor in glioma progress,which is closely related to the increasing of neovasculization factor.
2017, 42(6): 761-763.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.020
Abstract:
Objective: To study the effect of different doses of flurbiprofen injection on the analgesia and inflammatory cytokine levels in patients with differentiated thyroid cancer. Methods: One hundred and twenty patients with thyroid cancer in our hospital were selected as the research object.The patients were randomly divided into flurbiprofen axetil 0.5 mg/kg group in each group(group D1),flurbiprofen axetil 1 mg/kg group(group D2),flurbiprofen axetil 1.5 mg/kg group(group D3) and the control group of 30 cases in each group.The patients were given different dose of flurbiprofen in the end of the induction of anesthesia.The visual analogue scale (VAS) was used to assess the degree of pain in patients.The level of interleukin-6(IL-6),interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA).The adverse reactions were observed in each group. Results: The VAS score of postoperative 24 h was significantly lower than that of postoperative 2 h in group D1,group D2 and group D3.VAS score of postoperative 2 h in group D2 and group D3 was significantly lower than those in control group.VAS score of postoperative 12 h in group D1,group D2 and group D3 was significantly lower than that in control group.VAS score of postoperative 24 h in group D2 and group D3 was significantly lower than that in control group.The serum IL-6,IL-8 and TNF-α levels of group D1,group D2 and group D3 were significantly lower than those of the control group,the difference was statistically significant(P<0.05).The levels of IL-6,IL-8 and TNF-α in group D3 were significantly lower than those in other groups.There were no statistical difference in the incidence of adverse events in the four groups. Conclusions: Flurbiprofen axetil 1.5 mg/kg can significantly decrease the level of serum IL-6,IL-8 and TNF-α,and there were no significant increase in adverse reactions.
Objective: To study the effect of different doses of flurbiprofen injection on the analgesia and inflammatory cytokine levels in patients with differentiated thyroid cancer. Methods: One hundred and twenty patients with thyroid cancer in our hospital were selected as the research object.The patients were randomly divided into flurbiprofen axetil 0.5 mg/kg group in each group(group D1),flurbiprofen axetil 1 mg/kg group(group D2),flurbiprofen axetil 1.5 mg/kg group(group D3) and the control group of 30 cases in each group.The patients were given different dose of flurbiprofen in the end of the induction of anesthesia.The visual analogue scale (VAS) was used to assess the degree of pain in patients.The level of interleukin-6(IL-6),interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA).The adverse reactions were observed in each group. Results: The VAS score of postoperative 24 h was significantly lower than that of postoperative 2 h in group D1,group D2 and group D3.VAS score of postoperative 2 h in group D2 and group D3 was significantly lower than those in control group.VAS score of postoperative 12 h in group D1,group D2 and group D3 was significantly lower than that in control group.VAS score of postoperative 24 h in group D2 and group D3 was significantly lower than that in control group.The serum IL-6,IL-8 and TNF-α levels of group D1,group D2 and group D3 were significantly lower than those of the control group,the difference was statistically significant(P<0.05).The levels of IL-6,IL-8 and TNF-α in group D3 were significantly lower than those in other groups.There were no statistical difference in the incidence of adverse events in the four groups. Conclusions: Flurbiprofen axetil 1.5 mg/kg can significantly decrease the level of serum IL-6,IL-8 and TNF-α,and there were no significant increase in adverse reactions.
2017, 42(6): 764-766.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.021
Abstract:
Objective: To study the efficacy,adverse reaction and quality of life of the locally advanced gastric cancer patients treated with concurrent chemoradiotherapy. Methods: Sixty-eight postoperative patients with gastric cancer were randomly divided into the concurrent chemoradiotherapy group and single chemotherapy group(34 cases each group).The concurrent chemoradiotherapy group was treated with capecitabine combined with the intensity-modulated radiotherapy,while the single chemotherapy group was treated with oxaliplatin combined with capecitabine.The 1,2 and 3-year progression-free survival rates,overall survival rates,adverse reaction and quality of life between two groups were compared. Results: The 1,2 and 3-year progression-free survival rates in concurrent chemoradiotherapy group were higher than those in single chemotherapy group(P<0.05).The differences of the 1,2 and 3-year overall survival rates,incidence of more than or equal to grade 2 gastrointestinal reactions,hematological toxicity,peripheral nerve toxicity,incidence of more than or equal to grade 1 hand-foot syndrome and quality of life between two groups were not statistically significant(P>0.05). Conclusions: Compared with the single chemotherapy,the postoperative concurrent chemoradiotherapy can improve the 1,2 and 3-year progression-free survival rates,the adverse reaction can be tolerated,and do not reduce the quality of life of the patients.
Objective: To study the efficacy,adverse reaction and quality of life of the locally advanced gastric cancer patients treated with concurrent chemoradiotherapy. Methods: Sixty-eight postoperative patients with gastric cancer were randomly divided into the concurrent chemoradiotherapy group and single chemotherapy group(34 cases each group).The concurrent chemoradiotherapy group was treated with capecitabine combined with the intensity-modulated radiotherapy,while the single chemotherapy group was treated with oxaliplatin combined with capecitabine.The 1,2 and 3-year progression-free survival rates,overall survival rates,adverse reaction and quality of life between two groups were compared. Results: The 1,2 and 3-year progression-free survival rates in concurrent chemoradiotherapy group were higher than those in single chemotherapy group(P<0.05).The differences of the 1,2 and 3-year overall survival rates,incidence of more than or equal to grade 2 gastrointestinal reactions,hematological toxicity,peripheral nerve toxicity,incidence of more than or equal to grade 1 hand-foot syndrome and quality of life between two groups were not statistically significant(P>0.05). Conclusions: Compared with the single chemotherapy,the postoperative concurrent chemoradiotherapy can improve the 1,2 and 3-year progression-free survival rates,the adverse reaction can be tolerated,and do not reduce the quality of life of the patients.
2017, 42(6): 767-769.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.022
Abstract:
Objective: To investigate the effects of body mass index(BMI) in pre-pregnancy and different periods of pregnancy on gestational diabetes mellitus(GDM). Methods: The data of 2 260 singleton pregnancy women with complete prenatal records were retrospectively analyzed.The incidence rates of GDM between different BMI group in pre-pregnancy and different periods of pregnancy were compared. Results: The incidence rates of GDM in obese and overweight group during pre-pregnancy and early pregnancy were significantly higher than that in normal group and lean group(P<0.01).The incidence rate of GDM in obese group was higher than that in overweight group and normal group during mid-pregnancy(P<0.05).The difference of the incidence rate of GDM in different BMI groups during late pregnancy was not statistically significant(P>0.05). Conclusions: The overweight and obesity in pre-pregnancy,early pregnancy and mid-pregnancy can lead to the incidence increasing of GDM.The BMI in late pregnancy does not significantly affect the incidence of GDM,which may be related to the low body weight,insufficient normal body weight sample and intervention.
Objective: To investigate the effects of body mass index(BMI) in pre-pregnancy and different periods of pregnancy on gestational diabetes mellitus(GDM). Methods: The data of 2 260 singleton pregnancy women with complete prenatal records were retrospectively analyzed.The incidence rates of GDM between different BMI group in pre-pregnancy and different periods of pregnancy were compared. Results: The incidence rates of GDM in obese and overweight group during pre-pregnancy and early pregnancy were significantly higher than that in normal group and lean group(P<0.01).The incidence rate of GDM in obese group was higher than that in overweight group and normal group during mid-pregnancy(P<0.05).The difference of the incidence rate of GDM in different BMI groups during late pregnancy was not statistically significant(P>0.05). Conclusions: The overweight and obesity in pre-pregnancy,early pregnancy and mid-pregnancy can lead to the incidence increasing of GDM.The BMI in late pregnancy does not significantly affect the incidence of GDM,which may be related to the low body weight,insufficient normal body weight sample and intervention.
2017, 42(6): 769-771.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.023
Abstract:
Objective: To explore the value of the ST-segment elevation in lead avR of treadmill exercise test in the diagnosis of left coronary artery lesions. Methods: Eighty-two coronary artery disease patients with the positive treadmill exercise test were divided into the ST-segment elevation group(42 cases) and non-ST-segment elevation group(40 cases) according to the ST-segment elevation(≥ 0.01 mV).The coronary angiography(CAG) in two groups was examined. Results: Three cases of negative CAG and 39 cases of positive CAG in ST-segment elevation group,and 4 cases of negative CAG and 36 cases of positive CAG in non-ST-segment elevation group were identified.The incidence rate of proximal left anterior lesion in ST-segment elevation group(58.97%) was higher than that in non-ST-segment elevation group(33.33%)(P<0.05),but the incidence rate of distal left anterior lesion in ST-segment elevation group(5.13%) was lower than that in non-ST-segment elevation group(50.00%)(P<0.01).The differences of the incidence rates of left main branch,right coronary artery and three-branch lesions between two groups were not statistically significant(P>0.05).The positive predictive value of left main branch lesion was 70.00% under the condition of positive ST-elevation in lead avR,and the positive predictive value was 90.91% under the condition of combination of left main branch with proximal left anterior branch. Conclusions: The positive treadmill exercise test combined with ST-segment elevation ≥ 0.01 mV in lead avR has high diagnostic values in left coronary artery lesions.
Objective: To explore the value of the ST-segment elevation in lead avR of treadmill exercise test in the diagnosis of left coronary artery lesions. Methods: Eighty-two coronary artery disease patients with the positive treadmill exercise test were divided into the ST-segment elevation group(42 cases) and non-ST-segment elevation group(40 cases) according to the ST-segment elevation(≥ 0.01 mV).The coronary angiography(CAG) in two groups was examined. Results: Three cases of negative CAG and 39 cases of positive CAG in ST-segment elevation group,and 4 cases of negative CAG and 36 cases of positive CAG in non-ST-segment elevation group were identified.The incidence rate of proximal left anterior lesion in ST-segment elevation group(58.97%) was higher than that in non-ST-segment elevation group(33.33%)(P<0.05),but the incidence rate of distal left anterior lesion in ST-segment elevation group(5.13%) was lower than that in non-ST-segment elevation group(50.00%)(P<0.01).The differences of the incidence rates of left main branch,right coronary artery and three-branch lesions between two groups were not statistically significant(P>0.05).The positive predictive value of left main branch lesion was 70.00% under the condition of positive ST-elevation in lead avR,and the positive predictive value was 90.91% under the condition of combination of left main branch with proximal left anterior branch. Conclusions: The positive treadmill exercise test combined with ST-segment elevation ≥ 0.01 mV in lead avR has high diagnostic values in left coronary artery lesions.
2017, 42(6): 772-773,777.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.024
Abstract:
Objective: To investigate the curative effects of the high ligation of spermatic vein under laparoscopy combined with Compound Xuanju Capsule in the treatment of male infertility caused by spermophlebectasia. Methods: Thirty-three patients with male infertility caused by spermophlebectasia were investigated.The patients were treated with the high ligation of spermatic vein under laparoscopy combined with Compound Xuanju Capsule.The semen quality in 33 cases was compared,and the natural pregnancy rate of patients' spouse was analyzed. Results: Compared with before treatment,the main indictors of sperm(including the semen volume,sperm concentration,sperm motility,proportion of grade A sperm,and proportion of grade A and B sperm) were enhanced after treatment(P<0.05 to P<0.01).The natural pregnancy rate in patients' spouse wihtin 1 year was 39.4%. Conclusions: The treatment of the male infertility caused by spermophlebectasia with high ligation of spermatic vein under laparoscopy combined with Compound Xuanju Capsule is an effective method,which is worthy of chinical application.
Objective: To investigate the curative effects of the high ligation of spermatic vein under laparoscopy combined with Compound Xuanju Capsule in the treatment of male infertility caused by spermophlebectasia. Methods: Thirty-three patients with male infertility caused by spermophlebectasia were investigated.The patients were treated with the high ligation of spermatic vein under laparoscopy combined with Compound Xuanju Capsule.The semen quality in 33 cases was compared,and the natural pregnancy rate of patients' spouse was analyzed. Results: Compared with before treatment,the main indictors of sperm(including the semen volume,sperm concentration,sperm motility,proportion of grade A sperm,and proportion of grade A and B sperm) were enhanced after treatment(P<0.05 to P<0.01).The natural pregnancy rate in patients' spouse wihtin 1 year was 39.4%. Conclusions: The treatment of the male infertility caused by spermophlebectasia with high ligation of spermatic vein under laparoscopy combined with Compound Xuanju Capsule is an effective method,which is worthy of chinical application.
2017, 42(6): 774-777.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.025
Abstract:
Objective: To investigate the effects of the nickel-chrome(Ni-Cr)alloy porcelain crown,Co-Cr alloy porcelain crown and Zirconia all-ceramic restoration on periodontic tissue health. Methods: Fifty-eight patients were divided into the nickel-chrome(Ni-Cr)alloy crown restoration group(25 cases,group A),cobalt-chromium(Co-Cr)alloy crown restoration group(21 cases,group B) and Zirconia all-ceramic crown restoration group(12 cases,group C).The gingival bleeding index,plaque index(PLI),periodontal probing depth(PD)and gingival crevicalar fluid(GCF)and level of interleukin-8(IL-8)in gingival crevicalar fluid in three groups were detected after half a year of treatment. Results: There were no statistical significance in the PD and PLI between before and after half a year of restoration in three groups.The gingival bleeding index,amount of GCF and level of IL-8 in gingival crevicalar fluid in group A and group B increased after restoration(P<0.01).The difference of each indictor in group C between before and after restoration was not statistically significant(P>0.05).The difference of the amount of gingival crevicalar fluid between group A,and group B or C was statistically significant(P<0.01),the difference of the amount of gingival crevicalar fluid between group B and group C was not statistically significant(P>0.05).The level of IL-8 in group A after restoration significantly increased compared with the group B and group C(P<0.01),and the difference of the level of IL-8 between group B and group C was statistically significant(P<0.05). Conclusions: Three material restorations have a certain adverse influence on periodontic tissue,and the adverse effect of Zirconia all-ceramic restoration is minimum.
Objective: To investigate the effects of the nickel-chrome(Ni-Cr)alloy porcelain crown,Co-Cr alloy porcelain crown and Zirconia all-ceramic restoration on periodontic tissue health. Methods: Fifty-eight patients were divided into the nickel-chrome(Ni-Cr)alloy crown restoration group(25 cases,group A),cobalt-chromium(Co-Cr)alloy crown restoration group(21 cases,group B) and Zirconia all-ceramic crown restoration group(12 cases,group C).The gingival bleeding index,plaque index(PLI),periodontal probing depth(PD)and gingival crevicalar fluid(GCF)and level of interleukin-8(IL-8)in gingival crevicalar fluid in three groups were detected after half a year of treatment. Results: There were no statistical significance in the PD and PLI between before and after half a year of restoration in three groups.The gingival bleeding index,amount of GCF and level of IL-8 in gingival crevicalar fluid in group A and group B increased after restoration(P<0.01).The difference of each indictor in group C between before and after restoration was not statistically significant(P>0.05).The difference of the amount of gingival crevicalar fluid between group A,and group B or C was statistically significant(P<0.01),the difference of the amount of gingival crevicalar fluid between group B and group C was not statistically significant(P>0.05).The level of IL-8 in group A after restoration significantly increased compared with the group B and group C(P<0.01),and the difference of the level of IL-8 between group B and group C was statistically significant(P<0.05). Conclusions: Three material restorations have a certain adverse influence on periodontic tissue,and the adverse effect of Zirconia all-ceramic restoration is minimum.
2017, 42(6): 778-780.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.026
Abstract:
Objective: To investigate the effects of transabdominal amnioinfusion in the treatment of oligohydramnios during the second trimester and its effects on the prenatal outcome. Methods: Sixty-three patients with oligohydramnios during the second trimester were divided into the observation group and control group according to the voluntariness principle.The control group and observation group were treated with the conventional method and transabdominal amnioinfusion surgery,respectively.The curative effects was compared. Results: The diagnostic rate of ultrasound in observation group(93.3%) was significantly higher than that in control group(51.5%)(P<0.01).The gestational weeks,number of newborn and birth weight in observation group were significantly higher than those in control group(P<0.01),and the difference of the 1min Apgar score after birth between two groups was not statistically significant(P>0.05).The number of pulmonary hypoplasia in observation group was less than that in control group(P<0.05),and the differences of the number of fetal distress,chorioamnionitis and deformities between two groups were not statistically significant(P>0.05). Conclusions: The treatment of oligohydramnios during the second trimester with transabdominal amnioinfusion can timely excluded the fetal anomalies,effectively improve the prenatal outcome and reduce complications.
Objective: To investigate the effects of transabdominal amnioinfusion in the treatment of oligohydramnios during the second trimester and its effects on the prenatal outcome. Methods: Sixty-three patients with oligohydramnios during the second trimester were divided into the observation group and control group according to the voluntariness principle.The control group and observation group were treated with the conventional method and transabdominal amnioinfusion surgery,respectively.The curative effects was compared. Results: The diagnostic rate of ultrasound in observation group(93.3%) was significantly higher than that in control group(51.5%)(P<0.01).The gestational weeks,number of newborn and birth weight in observation group were significantly higher than those in control group(P<0.01),and the difference of the 1min Apgar score after birth between two groups was not statistically significant(P>0.05).The number of pulmonary hypoplasia in observation group was less than that in control group(P<0.05),and the differences of the number of fetal distress,chorioamnionitis and deformities between two groups were not statistically significant(P>0.05). Conclusions: The treatment of oligohydramnios during the second trimester with transabdominal amnioinfusion can timely excluded the fetal anomalies,effectively improve the prenatal outcome and reduce complications.
2017, 42(6): 781-783.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.027
Abstract:
Objective: To analyze the influencing factors of pregnancy in infertility patients with endometriosis(EMT) after laparoscopy. Methods: The clinical data of 160 infertility patients with EMT diagnosed by pathology were retrospectively analyzed.All patients were followed up for 1 year,and divided into the pregnancy group and non-pregnancy group.The influencing factors of pregnancy were analyzed using single factor analysis and multivariable logistic regression analysis. Results: After 1 year of following up,84 cases with pregnancy were found,and the pregnancy rate of which was 52.5%.Single factor analysis showed that age,pathological type,r-AFS stage,uterine adenomyosis,oviduct obstruction,postoperative drug use and assisted reproduction of patients were the influencing factors of pregnancy(P<0.05).Multivariable logistic regression analysis showed that age,drug use,r-AFS stage,oviduct obstruction and assisted reproduction were the independent risk factors of pregnancy in infertility patients with EMT after laparoscopy(P<0.05). Conclusions: Taking the comprehensive evaluation of patients and implementing the corresponding measures according to the related factors can improve the successful rate of pregnancy of patients.
Objective: To analyze the influencing factors of pregnancy in infertility patients with endometriosis(EMT) after laparoscopy. Methods: The clinical data of 160 infertility patients with EMT diagnosed by pathology were retrospectively analyzed.All patients were followed up for 1 year,and divided into the pregnancy group and non-pregnancy group.The influencing factors of pregnancy were analyzed using single factor analysis and multivariable logistic regression analysis. Results: After 1 year of following up,84 cases with pregnancy were found,and the pregnancy rate of which was 52.5%.Single factor analysis showed that age,pathological type,r-AFS stage,uterine adenomyosis,oviduct obstruction,postoperative drug use and assisted reproduction of patients were the influencing factors of pregnancy(P<0.05).Multivariable logistic regression analysis showed that age,drug use,r-AFS stage,oviduct obstruction and assisted reproduction were the independent risk factors of pregnancy in infertility patients with EMT after laparoscopy(P<0.05). Conclusions: Taking the comprehensive evaluation of patients and implementing the corresponding measures according to the related factors can improve the successful rate of pregnancy of patients.
2017, 42(6): 784-786.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.028
Abstract:
Objective: To discuss the clinical value of EMP(etoposide,methotrexate and platinum) chemotherapy in the treatment of gestational tophoblastic neoplasia(GTN). Methods: Twenty-two cases with GTN were treated with EMP program(including 6 cases treated with simple EMP program and EMP program as for second-line treatment in 16 cases).MTX as the initial chemotherapy in 7 cases(31.8%),FAV as the initial chemotherapy in 8 cases(18.2%),FAVE as the initial chemotherapy in 4 cases(18.2%),EMA-Co as the initial chemotherapy in 2 cases(9.1%) and VMP as the initial chemotherapy in 1 case(4.5%) were implemented.One cases were operated based on chemotherapy. Results: The serology index of all patients arrived at the complete alleviation,the alleviation rate of which was 100%(the simple program for 37.5%).The bone marrow suppression,digestive tract reaction,hair loss and slight hepatic and renal toxicity were the major adverse reactions,the difference of which was statistical significance(P<0.05).The IV degree neutropenia and Ⅲ degree thrombocytopenia in 1 case at three course of chemotherapy alleviated after the treatment with colony stimulating factor(CSF) and recombinant human interleukin-11.Twenty-two patients were followed up,the unintended pregnancy in 1 case after 2 months of chemotherapy was identified,who recovered normal after the abortion,and other cases were normal. Conclusions: The initial or second-line chemotherapy with EMP in the treatment of GTN is good effect,which is worthy of promotion.
Objective: To discuss the clinical value of EMP(etoposide,methotrexate and platinum) chemotherapy in the treatment of gestational tophoblastic neoplasia(GTN). Methods: Twenty-two cases with GTN were treated with EMP program(including 6 cases treated with simple EMP program and EMP program as for second-line treatment in 16 cases).MTX as the initial chemotherapy in 7 cases(31.8%),FAV as the initial chemotherapy in 8 cases(18.2%),FAVE as the initial chemotherapy in 4 cases(18.2%),EMA-Co as the initial chemotherapy in 2 cases(9.1%) and VMP as the initial chemotherapy in 1 case(4.5%) were implemented.One cases were operated based on chemotherapy. Results: The serology index of all patients arrived at the complete alleviation,the alleviation rate of which was 100%(the simple program for 37.5%).The bone marrow suppression,digestive tract reaction,hair loss and slight hepatic and renal toxicity were the major adverse reactions,the difference of which was statistical significance(P<0.05).The IV degree neutropenia and Ⅲ degree thrombocytopenia in 1 case at three course of chemotherapy alleviated after the treatment with colony stimulating factor(CSF) and recombinant human interleukin-11.Twenty-two patients were followed up,the unintended pregnancy in 1 case after 2 months of chemotherapy was identified,who recovered normal after the abortion,and other cases were normal. Conclusions: The initial or second-line chemotherapy with EMP in the treatment of GTN is good effect,which is worthy of promotion.
2017, 42(6): 787-790.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.029
Abstract:
Objective: To investigate the clinical effects of the modified Yangmo Decoction in the treatment of kidney deficiency and blood stasis type thin endometrium. Methods: Eighty patients with kidney deficiency and blood stasis type thin endometrium were divided into the observation group(n=40) and control group(n=40) according to the different treatment methods.The control group was treated with routine western medicine,and the observation group was treated with the modified Yangmo Decoction based on control group.The clinical efficacy of two groups was evaluated,and the endometrial thickness and hemodynamic changes of uterine basilar artery were examined by ultrasonography.The follicular development was observed,and the pregnancy rates of two groups were analyzed. Results: The total effective rate of the observation group(92.5%) was significantly higher than that of control group(75.00%)(P<0.05).There was no statistical significance in endometrial thickness between two groups before treatment(P>0.05),and the endometrial thickness in observation group was significantly thicker than that in control group after treatment(P<0.05).There were no statistical significances in the resistance index(RI) and pulsatility index(PI) between two groups before treatment(P>0.05).After treatment,the RI and PI in observation group were significantly lower than those in control group(P<0.05).After treatment,the initial number of follicles and follicular diameter in observation group were significantly higher than those in control group(P<0.05).The total number of follicles in observation group and control group was 55 and 49,respectively,and the 76.36% and 57.14% of follicles were mature follicles(diameter ≥ 18 mm)(P<0.05),and the difference of which was statistically significant(P<0.05).After treatment,the clinical pregnancy rate and biochemical pregnancy rate in observation group(47.50% and 22.50%) were significantly higher than those in control group(25.00% and 5.00%),respectively(P<0.05). Conclusions: Modified Yangmo Decoction is significantly effective in the treatment of kidney deficiency and blood stasis type thin endometrium,which plays an important role in improving the endometrial thickness,follicular development and pregnancy rate.
Objective: To investigate the clinical effects of the modified Yangmo Decoction in the treatment of kidney deficiency and blood stasis type thin endometrium. Methods: Eighty patients with kidney deficiency and blood stasis type thin endometrium were divided into the observation group(n=40) and control group(n=40) according to the different treatment methods.The control group was treated with routine western medicine,and the observation group was treated with the modified Yangmo Decoction based on control group.The clinical efficacy of two groups was evaluated,and the endometrial thickness and hemodynamic changes of uterine basilar artery were examined by ultrasonography.The follicular development was observed,and the pregnancy rates of two groups were analyzed. Results: The total effective rate of the observation group(92.5%) was significantly higher than that of control group(75.00%)(P<0.05).There was no statistical significance in endometrial thickness between two groups before treatment(P>0.05),and the endometrial thickness in observation group was significantly thicker than that in control group after treatment(P<0.05).There were no statistical significances in the resistance index(RI) and pulsatility index(PI) between two groups before treatment(P>0.05).After treatment,the RI and PI in observation group were significantly lower than those in control group(P<0.05).After treatment,the initial number of follicles and follicular diameter in observation group were significantly higher than those in control group(P<0.05).The total number of follicles in observation group and control group was 55 and 49,respectively,and the 76.36% and 57.14% of follicles were mature follicles(diameter ≥ 18 mm)(P<0.05),and the difference of which was statistically significant(P<0.05).After treatment,the clinical pregnancy rate and biochemical pregnancy rate in observation group(47.50% and 22.50%) were significantly higher than those in control group(25.00% and 5.00%),respectively(P<0.05). Conclusions: Modified Yangmo Decoction is significantly effective in the treatment of kidney deficiency and blood stasis type thin endometrium,which plays an important role in improving the endometrial thickness,follicular development and pregnancy rate.
2017, 42(6): 791-794.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.030
Abstract:
Objective: To investigate the effectiveness and safety of fractional laser combined with Jingtianquban Capsule in the treatment of female chloasma. Methods: One hundred and twenty-two female patients with chloasma were randomly divided into the control group and observation group.The control group and observation group were treated with fractional laser and fractional laser combined with Jingtianquban Capsule,respectively.The total skin lesion scores,clinical efficacy 12 weeks after treatment,recurrence rate during the 3 months of following-up,levels of serum estradiol,luteinizing hormone and follicle stimulating hormone,and other sex hormone levels before and after treatment between two groups was recorded and compared.The safety of two groups during the treatment and following-up period were evaluated. Results: The total scores of skin lesions 12 weeks after treatment and 3 months of following-up in two groups significantly decreased compared with before treatment(P<0.01),the decreasing degree of which in observation group was more than that in control group(P<0.01).The total effective rate of the observation group(86.89%) was significantly higher than that in control group(67.21%)(P<0.01),and the recurrence rate in observation group(4.92%) was significantly lower than that in control group(16.39%)(P<0.05).The levels of serum estradiol,luteinizing hormone and follicle stimulating hormone 12 weeks after treatment in two groups significantly decreased compared with before treatment(P<0.01),the decreasing degree of which in observation group was more than that in control group(P<0.01). Conclusions: The treatment of female chloasma with fractional laser combined with Jingtianquban Capsule can rapidly improve the skin lesions in the short term,is effective,safe and reliable with low recurrence rate,which has high clinical reference values.
Objective: To investigate the effectiveness and safety of fractional laser combined with Jingtianquban Capsule in the treatment of female chloasma. Methods: One hundred and twenty-two female patients with chloasma were randomly divided into the control group and observation group.The control group and observation group were treated with fractional laser and fractional laser combined with Jingtianquban Capsule,respectively.The total skin lesion scores,clinical efficacy 12 weeks after treatment,recurrence rate during the 3 months of following-up,levels of serum estradiol,luteinizing hormone and follicle stimulating hormone,and other sex hormone levels before and after treatment between two groups was recorded and compared.The safety of two groups during the treatment and following-up period were evaluated. Results: The total scores of skin lesions 12 weeks after treatment and 3 months of following-up in two groups significantly decreased compared with before treatment(P<0.01),the decreasing degree of which in observation group was more than that in control group(P<0.01).The total effective rate of the observation group(86.89%) was significantly higher than that in control group(67.21%)(P<0.01),and the recurrence rate in observation group(4.92%) was significantly lower than that in control group(16.39%)(P<0.05).The levels of serum estradiol,luteinizing hormone and follicle stimulating hormone 12 weeks after treatment in two groups significantly decreased compared with before treatment(P<0.01),the decreasing degree of which in observation group was more than that in control group(P<0.01). Conclusions: The treatment of female chloasma with fractional laser combined with Jingtianquban Capsule can rapidly improve the skin lesions in the short term,is effective,safe and reliable with low recurrence rate,which has high clinical reference values.
2017, 42(6): 796-798,805.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.032
Abstract:
Objective: To investigate the distribution characteristics and influence factors of metabolic syndrome(MS) of community population in Bengbu city using the cross-sectional study. Methods: Two thousand six hundred and eighty-nine adults from three communities selected by the stratified and cluster random sampling in Longzihu District of Bengbu City were investigated using questionnaire and laboratory test.The incidence rates of MS in different ages and genders were analyzed using the criteria of Chinese Diabetes Society of 2004.The effects of the age,sex,smoking,drinking wine,and intake of vegetable and fruis on the morbidity risk of MS were analyzed using binary logistic regression method. Results: Three hundred and thirty-nine participants were accorded with the criteria of MS,and the prevalence rate of MS was 13.72%(16.24% in male and 11.89% in female).With the increasing of age,the prevalence of MS increased(P<0.05).The prevalence rates of MS in male were higher than that in female among the population of 30~,40~and 80~year-old(P<0.05 to P<0.01),and the difference of the other age population between male and female was not statistically significant(P>0.05).The multivariate analysis showed that smoking was the risk factor of MS(P<0.01).The increasing of the intake of fruit and vegetable was the protective factor(P<0.01). Conclusions: The prevalence rate of MS of community population in Bengbu city is associated with the age of population,and which increases along with the increasing of age.No smoking and sufficient intake of fruit and vegetable can reduce the prevalence rate of MS.
Objective: To investigate the distribution characteristics and influence factors of metabolic syndrome(MS) of community population in Bengbu city using the cross-sectional study. Methods: Two thousand six hundred and eighty-nine adults from three communities selected by the stratified and cluster random sampling in Longzihu District of Bengbu City were investigated using questionnaire and laboratory test.The incidence rates of MS in different ages and genders were analyzed using the criteria of Chinese Diabetes Society of 2004.The effects of the age,sex,smoking,drinking wine,and intake of vegetable and fruis on the morbidity risk of MS were analyzed using binary logistic regression method. Results: Three hundred and thirty-nine participants were accorded with the criteria of MS,and the prevalence rate of MS was 13.72%(16.24% in male and 11.89% in female).With the increasing of age,the prevalence of MS increased(P<0.05).The prevalence rates of MS in male were higher than that in female among the population of 30~,40~and 80~year-old(P<0.05 to P<0.01),and the difference of the other age population between male and female was not statistically significant(P>0.05).The multivariate analysis showed that smoking was the risk factor of MS(P<0.01).The increasing of the intake of fruit and vegetable was the protective factor(P<0.01). Conclusions: The prevalence rate of MS of community population in Bengbu city is associated with the age of population,and which increases along with the increasing of age.No smoking and sufficient intake of fruit and vegetable can reduce the prevalence rate of MS.
2017, 42(6): 799-805.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.033
Abstract:
Objective: To investigate the overall level of health literacy of medical students,and analyze its influencing factor. Methods: Seven hundred and twenty-six medical students were randomly selected by the method of stratified cluster sampling in all grades from a medical college of Anhui province analysis.The Chinese citizens health literacy questionnaire was adopted.The influence factor of health literacy was analyzed using a multiple linear regression. Results: The scores of female's health literacy,literacy knowledge and behavior literacy were higher than those of male's(P<0.01).The scores of attitude literacy of people whose family monthly income was more than or equal to 3 000 yuan were higher than that of those whose family monthly income was less than 3 000 yuan(P<0.05).The differece of scores of knowledge literacy,attitude literacy,behavior literacy and health literacy in medical college students who had different healthy condition was significant(P<0.05).And the rest scores of other health literacy had no nostatistical difference(P>0.05).The scores of three dimensions of male's health literacy were less than that of female's(P<0.01).The scores of disease prevention and control,basic health care,and safety and first aid were increasing with the grade changing of the medical college students,whose differece was statistically significant(P<0.05 to P<0.01).The scores of three dimensions of health literacy of good and medium health condition of medical college students were higher than that of ill condition(P<0.05 to P<0.01).The scores of three dimensions of health literacy of medical college students had no statistical difference(P>0.05),which had close relation with elements as following:the only child or not,rural or urban,having lectures or not,parents' literacy,family monthly income and monthly living expense.Regression results showed that the main influencing factors of health literacy were gender,grade,parents' education and family income. Conclusions: The health literacy of medical college students is at a medium level,and the level of health literacy of the three dimensions is not balanced.Health education should be carried out through targetting the influencing factor,including major,grade,gender,parents' education,family income,and whether to participate in health lectures.
Objective: To investigate the overall level of health literacy of medical students,and analyze its influencing factor. Methods: Seven hundred and twenty-six medical students were randomly selected by the method of stratified cluster sampling in all grades from a medical college of Anhui province analysis.The Chinese citizens health literacy questionnaire was adopted.The influence factor of health literacy was analyzed using a multiple linear regression. Results: The scores of female's health literacy,literacy knowledge and behavior literacy were higher than those of male's(P<0.01).The scores of attitude literacy of people whose family monthly income was more than or equal to 3 000 yuan were higher than that of those whose family monthly income was less than 3 000 yuan(P<0.05).The differece of scores of knowledge literacy,attitude literacy,behavior literacy and health literacy in medical college students who had different healthy condition was significant(P<0.05).And the rest scores of other health literacy had no nostatistical difference(P>0.05).The scores of three dimensions of male's health literacy were less than that of female's(P<0.01).The scores of disease prevention and control,basic health care,and safety and first aid were increasing with the grade changing of the medical college students,whose differece was statistically significant(P<0.05 to P<0.01).The scores of three dimensions of health literacy of good and medium health condition of medical college students were higher than that of ill condition(P<0.05 to P<0.01).The scores of three dimensions of health literacy of medical college students had no statistical difference(P>0.05),which had close relation with elements as following:the only child or not,rural or urban,having lectures or not,parents' literacy,family monthly income and monthly living expense.Regression results showed that the main influencing factors of health literacy were gender,grade,parents' education and family income. Conclusions: The health literacy of medical college students is at a medium level,and the level of health literacy of the three dimensions is not balanced.Health education should be carried out through targetting the influencing factor,including major,grade,gender,parents' education,family income,and whether to participate in health lectures.
2017, 42(6): 806-807,810.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.034
Abstract:
Objective: To explore the value of the color Doppler flow imaging(CDFI) and virtual touch quantification(VTQ) in early diagnosis of hypertensive nephropathy. Methods: Forty hypertensive patients with urinary microalbumin(mALB) more than 200 mg/L,38 patients with 20 to 200 mg/L of mALB and 46 healthy people with negative mALB were divided into group A,B and C,respectively.The resistance indices(RI) in renal artery and interlobar artery,shear wave velocity(SWV) of renal cortex,medulla and sinus in three groups were detected,and the change characteristics of renal RI and SWV in three groups were analyzed. Results: The differences of the RI of renal artery and SWV of renal cortex and sinus were not statistically significant(P>0.05).The RI of interlobar artery in group C was less than that in groups A and B(P<0.05),and the difference of the RI of interlobar artery between group A and group B was not statistically significant(P>0.05).The SWV of renal medulla in group B and C was significantly lower than that in group A(P<0.01),but the difference of which between group B and C was not statistically significant(P>0.05). Conclusions: Detecting the RI of interlobar artery and SWV of renal medulla has important clinical significances in early diagnosis of hypertensive nephropathy.
Objective: To explore the value of the color Doppler flow imaging(CDFI) and virtual touch quantification(VTQ) in early diagnosis of hypertensive nephropathy. Methods: Forty hypertensive patients with urinary microalbumin(mALB) more than 200 mg/L,38 patients with 20 to 200 mg/L of mALB and 46 healthy people with negative mALB were divided into group A,B and C,respectively.The resistance indices(RI) in renal artery and interlobar artery,shear wave velocity(SWV) of renal cortex,medulla and sinus in three groups were detected,and the change characteristics of renal RI and SWV in three groups were analyzed. Results: The differences of the RI of renal artery and SWV of renal cortex and sinus were not statistically significant(P>0.05).The RI of interlobar artery in group C was less than that in groups A and B(P<0.05),and the difference of the RI of interlobar artery between group A and group B was not statistically significant(P>0.05).The SWV of renal medulla in group B and C was significantly lower than that in group A(P<0.01),but the difference of which between group B and C was not statistically significant(P>0.05). Conclusions: Detecting the RI of interlobar artery and SWV of renal medulla has important clinical significances in early diagnosis of hypertensive nephropathy.
2017, 42(6): 808-810.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.035
Abstract:
Objective: To explore the correlation between antenatal fetal lateral ventricle expansion and nervous system development in infants. Methods: Two hundred and twelve puerperas with mild simple lateral ventricle expansion fetus and 106 puerperas with healthy fetus diagnosed by prenatal color Doppler ultrasound were divided into the observation group and control group,respectively.The correlation between antenatal fetal lateral ventricle expansion and nervous system development in infants was analyzed. Results: Compared with the control group,the scores ofneonatal bebavioral neurological assessment,mental age and developmental quotient significantly decreased in observation group(P<0.05).There were not correlations in fetus gestational age of lateral ventricle expansion,change of the anterior horn of lateral ventricle,mental age and developmental quotient score(P>0.05).The abnormal number of lateral ventricle,width of anterior angle of lateral ventricle and change value of lateral ventricle posterior angle were negatively correlated with the neonatal bebavioral neurological assessment score,mental age and developmental quotient score(P<0.05 to P<0.01).The width of lateral ventricle posterior angle was significantly negatively correlated with the mental age and developmental quotient score(P<0.01). Conclusions: The expansion of the lateral ventricle affects the development of neonatal nervous system.The significant expansion of the width of lateral ventricle anterior and posterior angle can seriously reduce the development level of intelligence in neonates.
Objective: To explore the correlation between antenatal fetal lateral ventricle expansion and nervous system development in infants. Methods: Two hundred and twelve puerperas with mild simple lateral ventricle expansion fetus and 106 puerperas with healthy fetus diagnosed by prenatal color Doppler ultrasound were divided into the observation group and control group,respectively.The correlation between antenatal fetal lateral ventricle expansion and nervous system development in infants was analyzed. Results: Compared with the control group,the scores ofneonatal bebavioral neurological assessment,mental age and developmental quotient significantly decreased in observation group(P<0.05).There were not correlations in fetus gestational age of lateral ventricle expansion,change of the anterior horn of lateral ventricle,mental age and developmental quotient score(P>0.05).The abnormal number of lateral ventricle,width of anterior angle of lateral ventricle and change value of lateral ventricle posterior angle were negatively correlated with the neonatal bebavioral neurological assessment score,mental age and developmental quotient score(P<0.05 to P<0.01).The width of lateral ventricle posterior angle was significantly negatively correlated with the mental age and developmental quotient score(P<0.01). Conclusions: The expansion of the lateral ventricle affects the development of neonatal nervous system.The significant expansion of the width of lateral ventricle anterior and posterior angle can seriously reduce the development level of intelligence in neonates.
2017, 42(6): 811-813.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.036
Abstract:
Objective: To investigate the correlation between serum cystatin C(Cyst C) and glomerular filtration rate(GFR) in patients with chronic kidney disease(CKD),and explore the clinical value of serum Cyst C. Methods: The levels of serum Cyst C and creatinine(Scr) in 82 CKD patients were detected,the GFRInulin was detected by inulin clearance rate,and the GFRMDRD and GFRC-G were calculated using the simplified equations of MDRD and C-G.The GFRInulin was set as the standard value of GFR of CKD patients,the correlation between each parameter in different CKD stage patients was compared. Results: The level of Cyst C was negatively correlated with GFRInulin in CKD stage 1,2 and 3 patients(P<0.05 to P<0.01),and there was not obvious correlations between the level of Cyst C and GFRInulin in CKD stage 4 and 5 patients(P>0.05).There were correlations between the serum levels of Scr,GFRMDRD and GFRC-G,and GFRInulin in CKD stage 3 patients(P<0.01).In CKD stage 1 patients,the sensitivity and specificity of Cyst C were significantly higher than those of GFRMDRD and GFRC-G. Conclusions: The serum Cyst C can be acted as an index in evaluating GFR of CKD patients,and its clinical value is greater especially in early CKD.
Objective: To investigate the correlation between serum cystatin C(Cyst C) and glomerular filtration rate(GFR) in patients with chronic kidney disease(CKD),and explore the clinical value of serum Cyst C. Methods: The levels of serum Cyst C and creatinine(Scr) in 82 CKD patients were detected,the GFRInulin was detected by inulin clearance rate,and the GFRMDRD and GFRC-G were calculated using the simplified equations of MDRD and C-G.The GFRInulin was set as the standard value of GFR of CKD patients,the correlation between each parameter in different CKD stage patients was compared. Results: The level of Cyst C was negatively correlated with GFRInulin in CKD stage 1,2 and 3 patients(P<0.05 to P<0.01),and there was not obvious correlations between the level of Cyst C and GFRInulin in CKD stage 4 and 5 patients(P>0.05).There were correlations between the serum levels of Scr,GFRMDRD and GFRC-G,and GFRInulin in CKD stage 3 patients(P<0.01).In CKD stage 1 patients,the sensitivity and specificity of Cyst C were significantly higher than those of GFRMDRD and GFRC-G. Conclusions: The serum Cyst C can be acted as an index in evaluating GFR of CKD patients,and its clinical value is greater especially in early CKD.
2017, 42(6): 814-815,818.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.037
Abstract:
Objective: To compare the serum level of thymidine kinase 1 between respiratory inflammation and lung cancer patients. Methods: The acute inflammation patients,tumor patients and healthy people were divided into the inflammation group,tumor group and control group,respectively.The levels of TK1 between three groups were compared,and the correlation between TK1 and C-reactive protein(CRP) in inflammation group was analyzed. Results: The serum levels of TK1 in inflammation group and cancer group were higher than that in control group(P<0.05 to P<0.01).The serum level of TK1 in inflammation group was higher than that in cancer group(P<0.01).The TK1 level was significantly positively correlated with CRP level in inflammation group(P<0.01). Conclusions: Compared with tumor patient and healthy people,the serum level of TK1 in patients with respiratory inflammation significantly increases,and which is highly correlated to the CRP level.
Objective: To compare the serum level of thymidine kinase 1 between respiratory inflammation and lung cancer patients. Methods: The acute inflammation patients,tumor patients and healthy people were divided into the inflammation group,tumor group and control group,respectively.The levels of TK1 between three groups were compared,and the correlation between TK1 and C-reactive protein(CRP) in inflammation group was analyzed. Results: The serum levels of TK1 in inflammation group and cancer group were higher than that in control group(P<0.05 to P<0.01).The serum level of TK1 in inflammation group was higher than that in cancer group(P<0.01).The TK1 level was significantly positively correlated with CRP level in inflammation group(P<0.01). Conclusions: Compared with tumor patient and healthy people,the serum level of TK1 in patients with respiratory inflammation significantly increases,and which is highly correlated to the CRP level.
2017, 42(6): 816-818.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.038
Abstract:
Objective: To investigate the effects of family follow-up care mode on the prevention of swallowing disorder and quality of life in stroke patients. Methods: One hundred and twenty stroke patients were divided into the observation group(n=60) and control group(n=60) according to random number table.The control group and observation group were treated with routine guidance and family follow-up care at discharge,respectively.Two groups were intervened for 6 months.The swallowing function and quality of life improvement between two groups were compared. Results: The incidence rates of swallowing dysfunction,aspiration pneumonia,malnutrition in observation group were lower than those in control group,while the compliance of swallowing function training and satisfaction in observation group were higher than those in control group(P<0.05 to P<0.01).The scores of psychological dimension,physiological dimension,social adaptability and quality of life in two groups after intervention were higher than those in before intervention(P<0.01).The scores of psychological dimension,physiological dimension,social adaptability and quality of life in observation group were significantly higher than those in control group(P<0.01). Conclusions: Family follow-up care mode can effectively promote the rehabilitation of swallowing dysfunction and improve the quality of life of stroke patients.
Objective: To investigate the effects of family follow-up care mode on the prevention of swallowing disorder and quality of life in stroke patients. Methods: One hundred and twenty stroke patients were divided into the observation group(n=60) and control group(n=60) according to random number table.The control group and observation group were treated with routine guidance and family follow-up care at discharge,respectively.Two groups were intervened for 6 months.The swallowing function and quality of life improvement between two groups were compared. Results: The incidence rates of swallowing dysfunction,aspiration pneumonia,malnutrition in observation group were lower than those in control group,while the compliance of swallowing function training and satisfaction in observation group were higher than those in control group(P<0.05 to P<0.01).The scores of psychological dimension,physiological dimension,social adaptability and quality of life in two groups after intervention were higher than those in before intervention(P<0.01).The scores of psychological dimension,physiological dimension,social adaptability and quality of life in observation group were significantly higher than those in control group(P<0.01). Conclusions: Family follow-up care mode can effectively promote the rehabilitation of swallowing dysfunction and improve the quality of life of stroke patients.
2017, 42(6): 819-821.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.039
Abstract:
Objective: To analyze the nursing characteristics of 48 patients with cervical spine fracture-dislocation complicated with spinal cord injury,and provide the treatment measures in clinical complications and dysneuria. Methods: Forty-eight patients with cervical spine fracture-dislocation complicated with spinal cord injury were divided into the observation group and control group according to the random number table method(24 cases each group).The observation group and control group were nursed with comprehensive nursing mode and conventional nursing mode,respectively.The incidence of adverse reactions and SCL-90 score between two groups were compared. Results: The incidence rate of pressure ulcer in observation group was significantly lower than that in control group(P<0.01).The scores of sensitive interpersonal relationship,obsessional symptom,somatization,psychotic symptom,paranoia,depression,anxiety,hostility,fear and other items in observation group were significantly lower than those in control group(P<0.01). Conclusions: Compared with the conventional nursing mode,the comprehensive nursing mode has significant advantages,the incidence rate of adverse reaction is low,the SCL-90 scoring condition is good,which can improve the quality of life in patients with cervical spine fracture-dislocation complicated with spinal cord injury.
Objective: To analyze the nursing characteristics of 48 patients with cervical spine fracture-dislocation complicated with spinal cord injury,and provide the treatment measures in clinical complications and dysneuria. Methods: Forty-eight patients with cervical spine fracture-dislocation complicated with spinal cord injury were divided into the observation group and control group according to the random number table method(24 cases each group).The observation group and control group were nursed with comprehensive nursing mode and conventional nursing mode,respectively.The incidence of adverse reactions and SCL-90 score between two groups were compared. Results: The incidence rate of pressure ulcer in observation group was significantly lower than that in control group(P<0.01).The scores of sensitive interpersonal relationship,obsessional symptom,somatization,psychotic symptom,paranoia,depression,anxiety,hostility,fear and other items in observation group were significantly lower than those in control group(P<0.01). Conclusions: Compared with the conventional nursing mode,the comprehensive nursing mode has significant advantages,the incidence rate of adverse reaction is low,the SCL-90 scoring condition is good,which can improve the quality of life in patients with cervical spine fracture-dislocation complicated with spinal cord injury.
2017, 42(6): 822-825.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.040
Abstract:
Objective: To explore the preoperative motivational interviewing nursing mode on the incidence rate of postoperative cognitive dysfunction in patients treated with great vessel surgery. Methods: One hundred and fifty patients treated with aortic surgery with deep hypothermic circulatory arrest were randomly divided into the control group and observation group(75 cases each group).The control group was nursed with conventional care combined with visit before operation,and the observation group was additionally nursed with motivational interviewing based on control group.The scores of self-rating anxiety scale in two groups between before and after operation,and the incidence and prognosis of cognitive dysfunction after operation between two groups were compared.The long-term psychological state in two groups was evaluated after 6 months of following-up. Results: Within two weeks after operation,the anxiety score,incidence of cognitive dysfunction,variation range of systolic blood pressure,use of sedative drug,mechanical ventilation time,drainage volume during the first 24 hours and residence time in ICU in observation group were less than those in control group(P<0.05 to P<0.01),and the lowest oxygenation index in observation group was significantly higher than that in control group(P<0.01).After 6 months of following-up,the anxiety score and incidence rate of cognitive dysfunction in observation group were significantly less than those in control group(P<0.01). Conclusions: The motivational interviewing mode can effectively improve the stress and anxiety,occurrence rate of postoperative cognitive dysfunction,and prognosis of patients treated with great vessel surgery with deep hypothermic circulatory arrest,which is worthy of promotion in clinic.
Objective: To explore the preoperative motivational interviewing nursing mode on the incidence rate of postoperative cognitive dysfunction in patients treated with great vessel surgery. Methods: One hundred and fifty patients treated with aortic surgery with deep hypothermic circulatory arrest were randomly divided into the control group and observation group(75 cases each group).The control group was nursed with conventional care combined with visit before operation,and the observation group was additionally nursed with motivational interviewing based on control group.The scores of self-rating anxiety scale in two groups between before and after operation,and the incidence and prognosis of cognitive dysfunction after operation between two groups were compared.The long-term psychological state in two groups was evaluated after 6 months of following-up. Results: Within two weeks after operation,the anxiety score,incidence of cognitive dysfunction,variation range of systolic blood pressure,use of sedative drug,mechanical ventilation time,drainage volume during the first 24 hours and residence time in ICU in observation group were less than those in control group(P<0.05 to P<0.01),and the lowest oxygenation index in observation group was significantly higher than that in control group(P<0.01).After 6 months of following-up,the anxiety score and incidence rate of cognitive dysfunction in observation group were significantly less than those in control group(P<0.01). Conclusions: The motivational interviewing mode can effectively improve the stress and anxiety,occurrence rate of postoperative cognitive dysfunction,and prognosis of patients treated with great vessel surgery with deep hypothermic circulatory arrest,which is worthy of promotion in clinic.
2017, 42(6): 835-838.
doi: 10.13898/j.cnki.issn.1000-2200.2017.06.045
Abstract:
Objective: To evaluate the influence of teaching model of clinical college on the learning effect of nursing students. Methods: The nursing students from grade 2013 and grade 2014 with similar academic achievement and gender composition were randomly divided into the clinical college teaching class and traditional teaching class.The teaching effects of two classes were evaluated using course achievement and questionnaire. Results: There were no statistical significances in the average grade of medical nursing,surgical nursing,obstetrics and gynecology nursing,and pediatric nursing between two classes(P>0.05).The learning initiative and time management ability in clinical college teaching class were better than those in traditional teaching class(P<0.05).The learning efficiency and nursing technical operation ability in traditional teaching class were better than those in clinical college teaching class(P<0.05).The top three favorite teaching methods of students were case teaching method,scene simulation teaching method and bedside teaching method in turn. Conclusions: The course achievement of teaching model of clinical college is the same as the traditional teaching model,and teaching model of clinical college can help students to improve critical thinking,problems-solving ability,time management ability and autonomous learning ability.
Objective: To evaluate the influence of teaching model of clinical college on the learning effect of nursing students. Methods: The nursing students from grade 2013 and grade 2014 with similar academic achievement and gender composition were randomly divided into the clinical college teaching class and traditional teaching class.The teaching effects of two classes were evaluated using course achievement and questionnaire. Results: There were no statistical significances in the average grade of medical nursing,surgical nursing,obstetrics and gynecology nursing,and pediatric nursing between two classes(P>0.05).The learning initiative and time management ability in clinical college teaching class were better than those in traditional teaching class(P<0.05).The learning efficiency and nursing technical operation ability in traditional teaching class were better than those in clinical college teaching class(P<0.05).The top three favorite teaching methods of students were case teaching method,scene simulation teaching method and bedside teaching method in turn. Conclusions: The course achievement of teaching model of clinical college is the same as the traditional teaching model,and teaching model of clinical college can help students to improve critical thinking,problems-solving ability,time management ability and autonomous learning ability.
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