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2017 Vol. 42, No. 7
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2017, 42(7): 841-844.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.001
Abstract:
Objective:To analyze the correlation between the apolipoprotein E(ApoE) gene polymorphism and blood lipid in elders.Methods:Nine hundred and twenty-four elders aged over 55 years old were selected using typical sampling method.The cases were investigated using a questionnaire,and the blood lipid indicators were examined.The ApoE gene polymorphism was detected using the high resolution melting(HRM) curve method.The correlation between ApoE gene polymorphism and blood lipid was analyzed using ANOVA.Results:The differences of the levels of TG,HDL-C,ApoA,BMI and glucose in all cases were statistically significant(P<0.05).The proportion of E3 in all allele frequency distribution was the largest.The differences of the genotype distribution,allele frequency distribution and carry E4 frequency distribution among all cases were statistically significant(P<0.05).After the age and gender were controlled,the genotype was correlation with the HDL-C,LDL-C,ApoA and ApoB(P<0.05 to P<0.01).Conclusions:The blood lipid level is associated with age,and the ApoE4 carriers is significant associated with the blood lipid level of the elders in Ningxia.
Objective:To analyze the correlation between the apolipoprotein E(ApoE) gene polymorphism and blood lipid in elders.Methods:Nine hundred and twenty-four elders aged over 55 years old were selected using typical sampling method.The cases were investigated using a questionnaire,and the blood lipid indicators were examined.The ApoE gene polymorphism was detected using the high resolution melting(HRM) curve method.The correlation between ApoE gene polymorphism and blood lipid was analyzed using ANOVA.Results:The differences of the levels of TG,HDL-C,ApoA,BMI and glucose in all cases were statistically significant(P<0.05).The proportion of E3 in all allele frequency distribution was the largest.The differences of the genotype distribution,allele frequency distribution and carry E4 frequency distribution among all cases were statistically significant(P<0.05).After the age and gender were controlled,the genotype was correlation with the HDL-C,LDL-C,ApoA and ApoB(P<0.05 to P<0.01).Conclusions:The blood lipid level is associated with age,and the ApoE4 carriers is significant associated with the blood lipid level of the elders in Ningxia.
Effect of the neutrophil supernatant on the migration of human umbilical cord mesenchymal stem cells
2017, 42(7): 845-847,851.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.002
Abstract:
Objective:To investigate the effects of neutrophil supernatant on the migration of human umbilical cord mesenchymal stem cells(UC-MSCs) for providing a theoretical basis in treating the inflammatory disease with MSCs.Methods:The neutrophil cells were isolated form umbilical cord blood,co-cultured with UC-MSCs,and the neutrophil supernatant was extracted.The only UC-MSCs and co-culturing of UC-MSCs with different concentrations of neutrophil supernatant were divided into the control group and experimental group,respectively.The 18h and 40h was set as the culturing time.According to the experimental results of methyl thiazolyl tetrazolium(MTT),the ratios of UC-MSCs to neutrophil supernatant for 1∶0,1∶1 and 1∶50 were investigated.The migration of MSCs at different time-points within 24h were observed using the scratch method.Results:The result of scratch showed that the migration speed of MSCs in 1∶50 cells was significantly quicker than that in 1∶0 and 1∶1 cells.Conclusions:The high concentration of neutrophil supernatant can promote the migration of human umbilical cord MSCs.
Objective:To investigate the effects of neutrophil supernatant on the migration of human umbilical cord mesenchymal stem cells(UC-MSCs) for providing a theoretical basis in treating the inflammatory disease with MSCs.Methods:The neutrophil cells were isolated form umbilical cord blood,co-cultured with UC-MSCs,and the neutrophil supernatant was extracted.The only UC-MSCs and co-culturing of UC-MSCs with different concentrations of neutrophil supernatant were divided into the control group and experimental group,respectively.The 18h and 40h was set as the culturing time.According to the experimental results of methyl thiazolyl tetrazolium(MTT),the ratios of UC-MSCs to neutrophil supernatant for 1∶0,1∶1 and 1∶50 were investigated.The migration of MSCs at different time-points within 24h were observed using the scratch method.Results:The result of scratch showed that the migration speed of MSCs in 1∶50 cells was significantly quicker than that in 1∶0 and 1∶1 cells.Conclusions:The high concentration of neutrophil supernatant can promote the migration of human umbilical cord MSCs.
2017, 42(7): 848-851.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.003
Abstract:
Objective:To investigate the interleukin-10(IL-10) on the expression of miRNA-125b,and cell proliferation and apoptosis in non-small cell lung cancer.Methods:The expression level of miRNAs in H460 cells stimulated by IL-10 was detected using real-time fluorescent quantitative PCR.The effects on cell proliferation between IL-10 stimulating and recovery of miRNA-125b expression were compared using CCK8 method.The effects of IL-10 stimulating and recovery of miRNA-125b expression on cell apoptosis were evaluated by flow cytometry.The expressions of miRNA-125b in non-small cell lung cancer and adjacent tissues were verified by real-time fluorescent quantitative PCR.Results:There was different degree expressions of 21 kinds of miRNAs in H460 cells stimulated by IL-10,and the expression decreasing of miRNA-125b was the maximum.After the expression of miRNA-125b recovering,the proliferation and apoptosis of cell stimulated by IL-10 was inhibited and promoted,respectively(P<0.05).The expression of miRNA-125b in non-small cell lung cancer tissue was significantly lower than that in normal tissue(P<0.01).Conclusions:During the cell proliferation induced by IL-10,miRNA-125b can play a role on inhibiting cancer,which is expected to be used as a drug development target in the treatment of non-small cell lung cancer.
Objective:To investigate the interleukin-10(IL-10) on the expression of miRNA-125b,and cell proliferation and apoptosis in non-small cell lung cancer.Methods:The expression level of miRNAs in H460 cells stimulated by IL-10 was detected using real-time fluorescent quantitative PCR.The effects on cell proliferation between IL-10 stimulating and recovery of miRNA-125b expression were compared using CCK8 method.The effects of IL-10 stimulating and recovery of miRNA-125b expression on cell apoptosis were evaluated by flow cytometry.The expressions of miRNA-125b in non-small cell lung cancer and adjacent tissues were verified by real-time fluorescent quantitative PCR.Results:There was different degree expressions of 21 kinds of miRNAs in H460 cells stimulated by IL-10,and the expression decreasing of miRNA-125b was the maximum.After the expression of miRNA-125b recovering,the proliferation and apoptosis of cell stimulated by IL-10 was inhibited and promoted,respectively(P<0.05).The expression of miRNA-125b in non-small cell lung cancer tissue was significantly lower than that in normal tissue(P<0.01).Conclusions:During the cell proliferation induced by IL-10,miRNA-125b can play a role on inhibiting cancer,which is expected to be used as a drug development target in the treatment of non-small cell lung cancer.
2017, 42(7): 852-853,857.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.004
Abstract:
Objective:To investigate the relationships between serum uric acid(UA) level,and different motor subtypes and clinical stage of Parkinson's disease(PD).Methods:PD patients and age and sex-matched healthy people were divided into the PD group(n=50)and control group(HC group,n=50),respectively.The PD group were subdivided into TD group(tremor-dominant) and PIGD group(postural instability and gait difficulty-dominant) according to the dyskinesia symptom.The disease severity was evaluated by Hoehn-Yahr(H-Y) scale,which could evaluated for early-stage(H-Y<3) and advanced-stage(H-Y≥3).The serum levels of UA and creatinine(Cr) in all cases were measured.Results:The serum UA level in PD group was lower than that in HC group(P<0.01).Compared with the TD group,the serum level of UA in PIGD group was significantly decreased(P<0.05).The serum level of UA in middle and advanced PD patients was lower that in early patients(P<0.01).The difference of the serum level of Cr between all cases was not statistically significant(P>0.05).Conclusions:The UA change may be involved in the pathogenesis of different motor subtypes of PD,which may be a potential useful biomarker in predicting risk,and diagnosing the severity and motor subtype of PD.
Objective:To investigate the relationships between serum uric acid(UA) level,and different motor subtypes and clinical stage of Parkinson's disease(PD).Methods:PD patients and age and sex-matched healthy people were divided into the PD group(n=50)and control group(HC group,n=50),respectively.The PD group were subdivided into TD group(tremor-dominant) and PIGD group(postural instability and gait difficulty-dominant) according to the dyskinesia symptom.The disease severity was evaluated by Hoehn-Yahr(H-Y) scale,which could evaluated for early-stage(H-Y<3) and advanced-stage(H-Y≥3).The serum levels of UA and creatinine(Cr) in all cases were measured.Results:The serum UA level in PD group was lower than that in HC group(P<0.01).Compared with the TD group,the serum level of UA in PIGD group was significantly decreased(P<0.05).The serum level of UA in middle and advanced PD patients was lower that in early patients(P<0.01).The difference of the serum level of Cr between all cases was not statistically significant(P>0.05).Conclusions:The UA change may be involved in the pathogenesis of different motor subtypes of PD,which may be a potential useful biomarker in predicting risk,and diagnosing the severity and motor subtype of PD.
2017, 42(7): 854-857.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.005
Abstract:
Objective:To compare the efficacy between small incision non phacoemulsification,and coaxial micro incision 2.2 mm and 2.8 mm incision phacoemulsification.Methods:One hundred and twelve patients(112 eyes) with cataract were randomly divided into the small incision group(38 cases),2.2 mm group(37 cases) and 2.8 mm group(37 eyes).The uncorrected visual acuity,best corrected visual acuity,refractive status,corneal endothelial count and postoperative complications before operation,after 1 week and 1 month between three groups were compared.Results:Compared with before operation,the uncorrected visual acuity and best corrected in three groups were significantly improved after operation(P<0.05).The increasing degree of vision in small incision group,2.2 mm group and 2.8 mm group after 1 week and 1 month gradually decreased(P<0.01).Compared before operation,the corneal astigmatism in three groups significantly decreased after operation(P<0.01),and the differences of the corneal astigmatism after 1 week and 1 month of operation between three groups were statistically significant(P>0.05).The corneal endothelial cell counts in three groups significantly decreased after operation(P<0.01),the differences of which between three groups were not statistically different(P>0.05).There was no significant difference in the incidence rate of complications between the 3 groups after surgery(P>0.05).Conclusions:Small incision non phacoemulsification has the advantages of small trauma,quick recovery,good vision of naked eye,low cost and easy operation,which is worthy of promotion.
Objective:To compare the efficacy between small incision non phacoemulsification,and coaxial micro incision 2.2 mm and 2.8 mm incision phacoemulsification.Methods:One hundred and twelve patients(112 eyes) with cataract were randomly divided into the small incision group(38 cases),2.2 mm group(37 cases) and 2.8 mm group(37 eyes).The uncorrected visual acuity,best corrected visual acuity,refractive status,corneal endothelial count and postoperative complications before operation,after 1 week and 1 month between three groups were compared.Results:Compared with before operation,the uncorrected visual acuity and best corrected in three groups were significantly improved after operation(P<0.05).The increasing degree of vision in small incision group,2.2 mm group and 2.8 mm group after 1 week and 1 month gradually decreased(P<0.01).Compared before operation,the corneal astigmatism in three groups significantly decreased after operation(P<0.01),and the differences of the corneal astigmatism after 1 week and 1 month of operation between three groups were statistically significant(P>0.05).The corneal endothelial cell counts in three groups significantly decreased after operation(P<0.01),the differences of which between three groups were not statistically different(P>0.05).There was no significant difference in the incidence rate of complications between the 3 groups after surgery(P>0.05).Conclusions:Small incision non phacoemulsification has the advantages of small trauma,quick recovery,good vision of naked eye,low cost and easy operation,which is worthy of promotion.
2017, 42(7): 858-860.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.006
Abstract:
Objective:To compare the clinical effects between two different intraocular lens implantation in patients with high myopia complicated with cataract.Methods:A total 40 patients(60 eyes) with high myopia complicated with cataract were selected,and treated with phacoemulsification combined with intraocular lens implantation.Nineteen cases(31 eyes,A group) and 21 cases(29 eyes,B group) were treated with MI60 lens and MA60MA lens,respectively.The best corrected visual acuity(BCVA),intraocular pressure,anterior chamber depth before operation and after 6 months of operation,and complications between two groups were compared.Results:Compared before operation,the BCVA in two groups increased after 6 months of operation,and the difference of the BCVA between two groups was not statistically significant (P<0.05).There was no significant difference in intraocular pressure in two groups between before operation and after 6 months of operation (P>0.05).Compared before operation,the anterior chamber depth significantly deepened in two groups,and the deepening degree of anterior chamber in A group was more than that in B group(P<0.05).No serious complications occurred in two groups.Conclusions:Compared with MA60MA lens,the treatment of patients with high myopia complicated with cataract with MI60 can sustain the anterior chamber depth,reduce the occurrence of posterior capsular membrane ruffle and posterior capsular opacity,and the interference to vitreous retinal.
Objective:To compare the clinical effects between two different intraocular lens implantation in patients with high myopia complicated with cataract.Methods:A total 40 patients(60 eyes) with high myopia complicated with cataract were selected,and treated with phacoemulsification combined with intraocular lens implantation.Nineteen cases(31 eyes,A group) and 21 cases(29 eyes,B group) were treated with MI60 lens and MA60MA lens,respectively.The best corrected visual acuity(BCVA),intraocular pressure,anterior chamber depth before operation and after 6 months of operation,and complications between two groups were compared.Results:Compared before operation,the BCVA in two groups increased after 6 months of operation,and the difference of the BCVA between two groups was not statistically significant (P<0.05).There was no significant difference in intraocular pressure in two groups between before operation and after 6 months of operation (P>0.05).Compared before operation,the anterior chamber depth significantly deepened in two groups,and the deepening degree of anterior chamber in A group was more than that in B group(P<0.05).No serious complications occurred in two groups.Conclusions:Compared with MA60MA lens,the treatment of patients with high myopia complicated with cataract with MI60 can sustain the anterior chamber depth,reduce the occurrence of posterior capsular membrane ruffle and posterior capsular opacity,and the interference to vitreous retinal.
2017, 42(7): 861-863.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.007
Abstract:
Objective:To investigate the correlation between the serum level of aquaporin 4-antibody(AQP4-IgG) and the clinical feature in patients with neuromyelitis optica spectrum disorders(NMOSD).Methods:The score of the expanded disability status scale(EDSS) and serum levels of AQP4-IgG detected by indirect immunofluorescence assay in 38 NMOSD cases were investigated.The correlations between serum level of AQP4-IgG,clinical symptom,image manifestation were analyzed.Results:The positive AQP4-IgG antibody in 23 cases(60.5%) and AQP4-IgG negative antibody in 15 cases(39.5%) were identified,and the EDSS score in positive group was significantly higher than that in negative group(P<0.05).Spearman correlation analysis showed that the serum level of AQP4-IgG antibody was positive correlation with the EDSS score and lesion segment of spinal cord(P<0.01).Three cases recurred in positive group,and no case recurred in negative group.Conclusions:The nerve impairment in NMOSD patients with AQP4-IgG antibody positive is severe.The higher the antibody and more spinal cord lesion are,the poorer the prognosis is.The patient with AQP4-IgG antibody negative is easy to recur.
Objective:To investigate the correlation between the serum level of aquaporin 4-antibody(AQP4-IgG) and the clinical feature in patients with neuromyelitis optica spectrum disorders(NMOSD).Methods:The score of the expanded disability status scale(EDSS) and serum levels of AQP4-IgG detected by indirect immunofluorescence assay in 38 NMOSD cases were investigated.The correlations between serum level of AQP4-IgG,clinical symptom,image manifestation were analyzed.Results:The positive AQP4-IgG antibody in 23 cases(60.5%) and AQP4-IgG negative antibody in 15 cases(39.5%) were identified,and the EDSS score in positive group was significantly higher than that in negative group(P<0.05).Spearman correlation analysis showed that the serum level of AQP4-IgG antibody was positive correlation with the EDSS score and lesion segment of spinal cord(P<0.01).Three cases recurred in positive group,and no case recurred in negative group.Conclusions:The nerve impairment in NMOSD patients with AQP4-IgG antibody positive is severe.The higher the antibody and more spinal cord lesion are,the poorer the prognosis is.The patient with AQP4-IgG antibody negative is easy to recur.
2017, 42(7): 864-867.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.008
Abstract:
Objective:To evaluate the efficacy and safety of the neoadjuvant chemotherapy of paclitaxel or docetaxel combined with nedaplatin in stage Ⅰb2~Ⅱb cervical cancer.Methods:A total of 48 patients with stageⅠb2~Ⅱb cervical cancer diagnosed by pathology were investigated,and divided into the paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group(24 cases each group).The paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were treated with neoadjuvant chemotherapy for 1 cycle before radical hysterectomy and radical radiation therapy,respectively.The clinical effect and adverse reaction between two groups were compared.Results:The total effective rates in paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were 83.33% and 79.17%,respectively,and the difference of which was not statistically significant(P>0.05).The complete remission rates in paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were 29.17% and 16.67%,respectively,and the difference of which was not statistically significant(P>0.05).The excision rate in two groups was 100%.The incidence rates of high risk factors of postoperative adverse prognosis in paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were 33.33% and 16.67%,respectively.The 3-year free tumor survival rates and overall survival rates in paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were 91.67% ＆ 95.83% and 87.50% ＆ 95.83%,respectively,and the differences of which were not statistically significant(P>0.05).The difference of the total incidence rate of adverse reaction between two groups was not statistically significant(P>0.05).Conclusions:The neoadjuvant chemotherapy of paclitaxel or docetaxel combined with nedaplatin in stage Ⅰb2~Ⅱb cervical cancer is safe and effective.The clinical effect and adverse reaction of two methods are similar,and patients can tolerate.
Objective:To evaluate the efficacy and safety of the neoadjuvant chemotherapy of paclitaxel or docetaxel combined with nedaplatin in stage Ⅰb2~Ⅱb cervical cancer.Methods:A total of 48 patients with stageⅠb2~Ⅱb cervical cancer diagnosed by pathology were investigated,and divided into the paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group(24 cases each group).The paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were treated with neoadjuvant chemotherapy for 1 cycle before radical hysterectomy and radical radiation therapy,respectively.The clinical effect and adverse reaction between two groups were compared.Results:The total effective rates in paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were 83.33% and 79.17%,respectively,and the difference of which was not statistically significant(P>0.05).The complete remission rates in paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were 29.17% and 16.67%,respectively,and the difference of which was not statistically significant(P>0.05).The excision rate in two groups was 100%.The incidence rates of high risk factors of postoperative adverse prognosis in paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were 33.33% and 16.67%,respectively.The 3-year free tumor survival rates and overall survival rates in paclitaxel plus nedaplatin group and docetaxel plus nedaplatin group were 91.67% ＆ 95.83% and 87.50% ＆ 95.83%,respectively,and the differences of which were not statistically significant(P>0.05).The difference of the total incidence rate of adverse reaction between two groups was not statistically significant(P>0.05).Conclusions:The neoadjuvant chemotherapy of paclitaxel or docetaxel combined with nedaplatin in stage Ⅰb2~Ⅱb cervical cancer is safe and effective.The clinical effect and adverse reaction of two methods are similar,and patients can tolerate.
2017, 42(7): 868-870,874.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.009
Abstract:
Objective:To observe the clinical effects of parecoxib sodium in the prevention of hyperalgesia induced by remifentanyl anesthesia after operation.Methods:One hundred and six patients treated with laparoscopic cholecystectomy were divided into the control group and observation group according to the draw method(53 cases each group).The control group and observation group were treated with routine anesthesia and parecoxib sodium based on the control group,respectively.The heart rate(HR) of different time points,mean arterial pressure(MAP),score of visual analogue scale(VAS),consciousness recovery time,extubation time and adverse reactions between two groups were compared.Results:The HR and MAP of observation group at T1,T2 and T3 were lower than those of control group(P<0.05 to P<0.01) The VAS scores in two groups at T1,T2 and T3 increased(P<0.01),and the increasing degree of which in observation group was lower than that in control group(P<0.01),and the differences of the recovery time,extubation time and incidence rate of adverse reaction between two groups were not statistically significant(P>0.05).Conclusions:The clinical effect of parecoxib sodium in the prevention of hyperalgesia induced by remifentanyl anesthesia after operation is good,which is worthy of promotion.
Objective:To observe the clinical effects of parecoxib sodium in the prevention of hyperalgesia induced by remifentanyl anesthesia after operation.Methods:One hundred and six patients treated with laparoscopic cholecystectomy were divided into the control group and observation group according to the draw method(53 cases each group).The control group and observation group were treated with routine anesthesia and parecoxib sodium based on the control group,respectively.The heart rate(HR) of different time points,mean arterial pressure(MAP),score of visual analogue scale(VAS),consciousness recovery time,extubation time and adverse reactions between two groups were compared.Results:The HR and MAP of observation group at T1,T2 and T3 were lower than those of control group(P<0.05 to P<0.01) The VAS scores in two groups at T1,T2 and T3 increased(P<0.01),and the increasing degree of which in observation group was lower than that in control group(P<0.01),and the differences of the recovery time,extubation time and incidence rate of adverse reaction between two groups were not statistically significant(P>0.05).Conclusions:The clinical effect of parecoxib sodium in the prevention of hyperalgesia induced by remifentanyl anesthesia after operation is good,which is worthy of promotion.
2017, 42(7): 871-874.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.010
Abstract:
Objective:To investigate the clinical value of combined detection of the serum cancer antigen15-3(CA15-3),carcinoembryonic antigen(CEA),tumor specific growth factor(TSGF),cancer antigen125(CA125) and growth differentiation factor 3(GDF3) in the diagnosis of breast cancer.Methods:Fifty-six patients with primary breast cancer,44 patients with benign breast tumor and 52 healthy females were divided into the breast cancer group,benign group and control group,respectively.The 3ml peripheral blood of fasting state in all cases was collected,and centrifuged.The serum levels of CA15-3,CA125 and CEA were detected by chemiluminescence method,the TSGF was detected by chemical colorimetric method,and GDF3 was detected by enzyme linked immunosorbent assay.Results:The serum levels of five tumor markers in breast cancer group were significantly higher than those in benign group and control group(P<0.01).Except for the level of TSGF in benign group were significantly higher than that in control group(P<0.01),and the differences of the levels of other four markers between benign group and control group were not statistically significant(P>0.05).The sensitivities of the separate detection of CA15-3,CEA,TSGF,CA125 and GDF3 were 32.1%,26.8%,21.4%,17.9% and 16.1%,respectively,and the sensitivity of combined detection was 64.3%,and higher than that of one tumor marker detection(P<0.05).The specificities of the separate detection of CA15-3,CEA,TSGF,CA125 and GDF3 were 88.6%,97.7%,77.3%,68.2% and 77.3%,respectively,and the specificity of combined detection was 72.7%.The specificity of CEA detection was the best,and which was higher than that of GdF3,CA125 and TSGF detection alone(P<0.05).The accuracies of the separate detection CA15-3,CEA,TSGF,CA125 and GDF3 were 57.0%,58.0%,46.0%,40.0% and 43.0%,respectively.The accuracy of combined detection was 68.0%,and which was higher than that of GDF3,CA125 and TSGF detection alone(P<0.05).Conclusions:The combined detection of tumor markers in the diagnosis of breast cancer has more higher sensitivity and accuracy,which can reduce the clinical misdiagnosis rate,and has important clinical application value.
Objective:To investigate the clinical value of combined detection of the serum cancer antigen15-3(CA15-3),carcinoembryonic antigen(CEA),tumor specific growth factor(TSGF),cancer antigen125(CA125) and growth differentiation factor 3(GDF3) in the diagnosis of breast cancer.Methods:Fifty-six patients with primary breast cancer,44 patients with benign breast tumor and 52 healthy females were divided into the breast cancer group,benign group and control group,respectively.The 3ml peripheral blood of fasting state in all cases was collected,and centrifuged.The serum levels of CA15-3,CA125 and CEA were detected by chemiluminescence method,the TSGF was detected by chemical colorimetric method,and GDF3 was detected by enzyme linked immunosorbent assay.Results:The serum levels of five tumor markers in breast cancer group were significantly higher than those in benign group and control group(P<0.01).Except for the level of TSGF in benign group were significantly higher than that in control group(P<0.01),and the differences of the levels of other four markers between benign group and control group were not statistically significant(P>0.05).The sensitivities of the separate detection of CA15-3,CEA,TSGF,CA125 and GDF3 were 32.1%,26.8%,21.4%,17.9% and 16.1%,respectively,and the sensitivity of combined detection was 64.3%,and higher than that of one tumor marker detection(P<0.05).The specificities of the separate detection of CA15-3,CEA,TSGF,CA125 and GDF3 were 88.6%,97.7%,77.3%,68.2% and 77.3%,respectively,and the specificity of combined detection was 72.7%.The specificity of CEA detection was the best,and which was higher than that of GdF3,CA125 and TSGF detection alone(P<0.05).The accuracies of the separate detection CA15-3,CEA,TSGF,CA125 and GDF3 were 57.0%,58.0%,46.0%,40.0% and 43.0%,respectively.The accuracy of combined detection was 68.0%,and which was higher than that of GDF3,CA125 and TSGF detection alone(P<0.05).Conclusions:The combined detection of tumor markers in the diagnosis of breast cancer has more higher sensitivity and accuracy,which can reduce the clinical misdiagnosis rate,and has important clinical application value.
2017, 42(7): 875-877.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.011
Abstract:
Objective:To investigate the difference and significance of the expression of regulatory T cells in peripheral blood of chronic hepatitis B(CHB) patients treated with interferon and nucleotide analogue.Methods:Ten CHB patients were treated with interferon(IFN group),and 13 CHB patients were treated with nucleoside(acid) analogue (nucleoside group).The ratio of the peripheral blood CD4+CD25+CD127low/-Tregs was detected before and during treatment,and the difference of which was compared.Results:The CD4+CD25+CD127low/-Treg cells in two groups showed a downward trend,the difference between two groups was statistically significant(P<0.01).The differences of cells at the beginning of treatment,and at 3 and 6 months of treatment between two groups were not statistically significant(P>0.05),and the difference of which at 9 months of treatment between two groups was statistically significant(P<0.05).Conclusions:The effect of interferon on the level of CD4+CD25+CD127low/-Treg cells in peripheral blood of patients with CHB is greater than that of nucleoside analogue,which suggests that it may have long-term immunomodulatory effects.
Objective:To investigate the difference and significance of the expression of regulatory T cells in peripheral blood of chronic hepatitis B(CHB) patients treated with interferon and nucleotide analogue.Methods:Ten CHB patients were treated with interferon(IFN group),and 13 CHB patients were treated with nucleoside(acid) analogue (nucleoside group).The ratio of the peripheral blood CD4+CD25+CD127low/-Tregs was detected before and during treatment,and the difference of which was compared.Results:The CD4+CD25+CD127low/-Treg cells in two groups showed a downward trend,the difference between two groups was statistically significant(P<0.01).The differences of cells at the beginning of treatment,and at 3 and 6 months of treatment between two groups were not statistically significant(P>0.05),and the difference of which at 9 months of treatment between two groups was statistically significant(P<0.05).Conclusions:The effect of interferon on the level of CD4+CD25+CD127low/-Treg cells in peripheral blood of patients with CHB is greater than that of nucleoside analogue,which suggests that it may have long-term immunomodulatory effects.
2017, 42(7): 878-880,884.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.012
Abstract:
Objective:To explore the curative effects and adverse reactions of GP combined with thalidomide in the treatment of advanced triple-negative breast cancer.Methods:A total of 58 patients with advanced triple-negative breast cancer were randomly divided into the GP combined with thalidomide group(combination group) and GP group(chemotherapy group)(29 cases each group).The curative effect,adverse reaction,tumor marker and median survival time(MST) between two groups were compared.Results:The effective rate in combination group(58.62%) was higher than that in chemothreapy group(31.03%)(P<0.05).The MST in combination group(37 months) was higher than that in chemothreapy group(32 months)(P<0.05).The decline rate of tumor markers in combination group(65.51%) was higher than that in chemothreapy group(37.93%)(P<0.05).The gastrointestinal reaction rate in combination group(13.79%) was lower than that in chemothreapy group(41.38%)(P<0.05).The difference of the incidence rates of the bone marrow depression and constipation between two groups were not statistically significant(P>0.05),other adverse rections were not obvious.Conclusions:GP combined with thalidomide in treating advanced triple-negative breast cancer is good curative effect and mild adverse reactions,which is worthy of promotion.
Objective:To explore the curative effects and adverse reactions of GP combined with thalidomide in the treatment of advanced triple-negative breast cancer.Methods:A total of 58 patients with advanced triple-negative breast cancer were randomly divided into the GP combined with thalidomide group(combination group) and GP group(chemotherapy group)(29 cases each group).The curative effect,adverse reaction,tumor marker and median survival time(MST) between two groups were compared.Results:The effective rate in combination group(58.62%) was higher than that in chemothreapy group(31.03%)(P<0.05).The MST in combination group(37 months) was higher than that in chemothreapy group(32 months)(P<0.05).The decline rate of tumor markers in combination group(65.51%) was higher than that in chemothreapy group(37.93%)(P<0.05).The gastrointestinal reaction rate in combination group(13.79%) was lower than that in chemothreapy group(41.38%)(P<0.05).The difference of the incidence rates of the bone marrow depression and constipation between two groups were not statistically significant(P>0.05),other adverse rections were not obvious.Conclusions:GP combined with thalidomide in treating advanced triple-negative breast cancer is good curative effect and mild adverse reactions,which is worthy of promotion.
2017, 42(7): 881-884.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.013
Abstract:
Objective:To study the effects of sufentanil anesthesia on craniocerebral injury patients treated with operation.Methods:Seventy-eight patients scheduled by craniotomy were randomly divided into the observation group and control group(39 cases each group).The control group and observation group were anaesthetized by remifentanil and sufentanil,respectively.The heart rate(HR),blood pressure,and levels of blood epinephrine(AD),noradrenaline(NE) and cortisol(CORT) between two groups were compared before induction anesthesia(T0),during nasotracheal intubation(T1),after 3 and 5 min of extubation(T2 and T3),and during extubation(T4).The breathing recovery time,opening eye time,conscious time,extubation time and extubation reaction after operation in two groups were recorded.Results:Hemodynamics:compared with T0,the levels of systolic pressure(SBP),diastolic pressure(DBP),HR and oxygen saturation(SpO2) in two groups significantly decreased at T1,T2,T3 and T4(P<0.01).The levels of SBP and HR in observation group at T1,T2,T3 and T4 were significantly higher than those in control group(P<0.01),the levels of DBP in observation group at T1,and T2 and T4 were lower and higher than that in control group,respectively(P<0.01),and the difference of the level of DBP at T3 between two groups was not statistically significant(P>0.05).The levels of SpO2 in observation group at T2 and T4 were higher than that in control group(P<0.01),and the difference of the level of SpO2 at T3 between two groups was not statistically significant(P>0.05).Blood index detection:compared with T0,the levels of AD,NE and CORT in control group significantly increased at T1,T2 and T3(P<0.01),and the differences of the levels of AD,NE and CORT in observation group between all time-points were not statistically significant(P>0.05).The levels of AD,NE and CORT in observation group at T1,T2 and T3 were significantly lower than those in control group(P<0.01).Postoperative observation:the spontaneous breathing recovery time,opening eye time,conscious time and extubation time in observation group were significantly longer than those in control group(P<0.01),and the extubation reaction rate in observation group was lower than that in control group(P<0.05).Conclusions:Compared with remifentanil,the sufentanil anesthesia can reduce cardiovascular stimulation,and the intraoperative and postoperative extubation stress reaction in craniocerebral injury patients treated with operation.
Objective:To study the effects of sufentanil anesthesia on craniocerebral injury patients treated with operation.Methods:Seventy-eight patients scheduled by craniotomy were randomly divided into the observation group and control group(39 cases each group).The control group and observation group were anaesthetized by remifentanil and sufentanil,respectively.The heart rate(HR),blood pressure,and levels of blood epinephrine(AD),noradrenaline(NE) and cortisol(CORT) between two groups were compared before induction anesthesia(T0),during nasotracheal intubation(T1),after 3 and 5 min of extubation(T2 and T3),and during extubation(T4).The breathing recovery time,opening eye time,conscious time,extubation time and extubation reaction after operation in two groups were recorded.Results:Hemodynamics:compared with T0,the levels of systolic pressure(SBP),diastolic pressure(DBP),HR and oxygen saturation(SpO2) in two groups significantly decreased at T1,T2,T3 and T4(P<0.01).The levels of SBP and HR in observation group at T1,T2,T3 and T4 were significantly higher than those in control group(P<0.01),the levels of DBP in observation group at T1,and T2 and T4 were lower and higher than that in control group,respectively(P<0.01),and the difference of the level of DBP at T3 between two groups was not statistically significant(P>0.05).The levels of SpO2 in observation group at T2 and T4 were higher than that in control group(P<0.01),and the difference of the level of SpO2 at T3 between two groups was not statistically significant(P>0.05).Blood index detection:compared with T0,the levels of AD,NE and CORT in control group significantly increased at T1,T2 and T3(P<0.01),and the differences of the levels of AD,NE and CORT in observation group between all time-points were not statistically significant(P>0.05).The levels of AD,NE and CORT in observation group at T1,T2 and T3 were significantly lower than those in control group(P<0.01).Postoperative observation:the spontaneous breathing recovery time,opening eye time,conscious time and extubation time in observation group were significantly longer than those in control group(P<0.01),and the extubation reaction rate in observation group was lower than that in control group(P<0.05).Conclusions:Compared with remifentanil,the sufentanil anesthesia can reduce cardiovascular stimulation,and the intraoperative and postoperative extubation stress reaction in craniocerebral injury patients treated with operation.
2017, 42(7): 885-887.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.014
Abstract:
Objective:To investigate the efficacy of the bilateral vertebral lamina fenestration,reseting combined with interbody fusion under retaining spinous process and ligament complex in the treatment of lumber spondylolisthesis.Methods:Thirty-one patients with lumbar spondylolisthesis were randomly divided into the retaining spinous process(group A) and total laminectomy group(group B).The A group were treated with bilateral vertebral lamina fenestration,decompress combined with interbody fusion,and the group B were treated with total laminectomy decompress combined with interbody fusion.The JOA scores before and after operation,operation time,blood loss,postoperative drainage and fusion rate after 3 months of operation between two groups were compared.Results:The change of JOA score between before and after operation in group A was significantly higher than that in group B(P<0.05).The postoperative drainage volume in group A was significantly lower than that in group B(P<0.05).The differences of the fusion rate after 3 months of operation,operation time and peroperative bleeding between two groups were not statistically significant(P>0.05).Conclusions:Under remaining spinous process and ligament complex,the treatment of lumber spondylolisthesis with bilateral vertebral lamina fenestration combined with interbody fusion is a good method.
Objective:To investigate the efficacy of the bilateral vertebral lamina fenestration,reseting combined with interbody fusion under retaining spinous process and ligament complex in the treatment of lumber spondylolisthesis.Methods:Thirty-one patients with lumbar spondylolisthesis were randomly divided into the retaining spinous process(group A) and total laminectomy group(group B).The A group were treated with bilateral vertebral lamina fenestration,decompress combined with interbody fusion,and the group B were treated with total laminectomy decompress combined with interbody fusion.The JOA scores before and after operation,operation time,blood loss,postoperative drainage and fusion rate after 3 months of operation between two groups were compared.Results:The change of JOA score between before and after operation in group A was significantly higher than that in group B(P<0.05).The postoperative drainage volume in group A was significantly lower than that in group B(P<0.05).The differences of the fusion rate after 3 months of operation,operation time and peroperative bleeding between two groups were not statistically significant(P>0.05).Conclusions:Under remaining spinous process and ligament complex,the treatment of lumber spondylolisthesis with bilateral vertebral lamina fenestration combined with interbody fusion is a good method.
2017, 42(7): 888-890.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.015
Abstract:
Objective:To study the correlation between homocysteine(Hcy) level and acute cerebral infarction.Methods:One hundred and twenty patients with acute cerebral infarction patients were detected using the carotid color ultrasonography,and the Hcy levels and blood routine biochemical indexes in all cases were examined.The patients were divided into two groups according to the degree of vascular stenosis,TOAST classification and carotid atherosclerosis plaque.The correlations between the degree of intracranial artery stenosis,carotid atherosclerosis plaque and cerebral infarction type,and Hcy levels were compared.The never function of the patients was evaluated using the modified Rankin scale(mRS),and the cardiovascular and cerebrovascular events and correlation between mRS score and Hcy level in all cases were analyzed.Results:The level rate of Hcy in non-stenosis group was significantly lower than that in stenosis group(P<0.01),and the difference of the incidence rate in different degree stenosis patients was statistically significant(P<0.01).The level of high homocysteine(HHcy) and Hcy in non-stenosis group were significantly lower than those in stenosis group(P<0.01).The differences of the incidence rates in large-artery atherosclerosis(LAA),cardiogenic cerebral embolism(CE),small arterial occlusive or lacunar stroke(SAA),stroke of other demonstrated etiology(SOE) and stroke of other undermonstrated etiology(SUE) groups were not statistically significant(P>0.05),the difference of the value of Hcy in each group was statistically significant(P<0.01),and the level of Hcy in LAA group was higher than that in CE,SAA,SUE and SOE groups(P<0.05 to P<0.01).The total incidence rate of the cardiovascular event in HHcy group was higher than that in normal Hcy group(P<0.05),and the mRS score in HHcy group was significantly higher than that in normal Hcy group(P<0.01).Conclusions:The intracranial artery stenosis severity,TOAST classification and carotid atherosclerosis plaque are related to the blood Hcy.The HHcy is an important factor leading to the poor prognosis of patients with acute cerebral infarction.
Objective:To study the correlation between homocysteine(Hcy) level and acute cerebral infarction.Methods:One hundred and twenty patients with acute cerebral infarction patients were detected using the carotid color ultrasonography,and the Hcy levels and blood routine biochemical indexes in all cases were examined.The patients were divided into two groups according to the degree of vascular stenosis,TOAST classification and carotid atherosclerosis plaque.The correlations between the degree of intracranial artery stenosis,carotid atherosclerosis plaque and cerebral infarction type,and Hcy levels were compared.The never function of the patients was evaluated using the modified Rankin scale(mRS),and the cardiovascular and cerebrovascular events and correlation between mRS score and Hcy level in all cases were analyzed.Results:The level rate of Hcy in non-stenosis group was significantly lower than that in stenosis group(P<0.01),and the difference of the incidence rate in different degree stenosis patients was statistically significant(P<0.01).The level of high homocysteine(HHcy) and Hcy in non-stenosis group were significantly lower than those in stenosis group(P<0.01).The differences of the incidence rates in large-artery atherosclerosis(LAA),cardiogenic cerebral embolism(CE),small arterial occlusive or lacunar stroke(SAA),stroke of other demonstrated etiology(SOE) and stroke of other undermonstrated etiology(SUE) groups were not statistically significant(P>0.05),the difference of the value of Hcy in each group was statistically significant(P<0.01),and the level of Hcy in LAA group was higher than that in CE,SAA,SUE and SOE groups(P<0.05 to P<0.01).The total incidence rate of the cardiovascular event in HHcy group was higher than that in normal Hcy group(P<0.05),and the mRS score in HHcy group was significantly higher than that in normal Hcy group(P<0.01).Conclusions:The intracranial artery stenosis severity,TOAST classification and carotid atherosclerosis plaque are related to the blood Hcy.The HHcy is an important factor leading to the poor prognosis of patients with acute cerebral infarction.
2017, 42(7): 891-893.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.016
Abstract:
Objective:To explore the postpartum glucose metabolism outcome and its influencing factors in patients with gestational diabetes mellitus(GDM) for providing the reference to prevent the abnormal postpartum glucose metabolism.Methods:The clinical data of 931 patients with GDM were collected.The postpartum 6 to 12 weeks glucose metabolism information was investigated,and the related factors of abnormal postpartum glucose metabolism were analyzed.Results:Among 931 patients,308 cases(33.08%) with abnormal glucose metabolism were found after 6 to 12 weeks of delivery,which included 35 cases of diabetes mellitus,14 cases of impaired fasting glucose(IFG),7 cases of IFG complicated with impaired glucose tolerance(IGT) and 252 cases of impaired glucose tolerance(IGT).The levels of the gestational fasthg plasma glucose(FPG),2h plasma glucose(2hPG),and 3h plasma glucose(3hPG) in GDM patients with abnormal postpartum glucose metabolism were higher than those in normal group(P<0.01),but the neonatal body weight was lower than that in normal group(P<0.01).The univariate analysis showed the gestational FPG,2hPG,3hPG and neonatal body weight were the influencing factors of the GDM patients with abnormal postpartum glucose metabolism.The multivariate analysis showed that the gestational FPG,2hPG and 3hPG were the independent risk factor of abnormal postpartum glucose metabolism.The higher the value of FPG(OR=3.528),2hPG(OR=1.579) and 3hPG(OR=1.655) were,the higher the risk of abnormal postpartum glucose metabolism was.Conclusions:The postpartum abnormal glucose metabolism can be found in partial GDM patients,which is related to the result of OGTT.The pertinent following up administration and preventing measures should be developed.
Objective:To explore the postpartum glucose metabolism outcome and its influencing factors in patients with gestational diabetes mellitus(GDM) for providing the reference to prevent the abnormal postpartum glucose metabolism.Methods:The clinical data of 931 patients with GDM were collected.The postpartum 6 to 12 weeks glucose metabolism information was investigated,and the related factors of abnormal postpartum glucose metabolism were analyzed.Results:Among 931 patients,308 cases(33.08%) with abnormal glucose metabolism were found after 6 to 12 weeks of delivery,which included 35 cases of diabetes mellitus,14 cases of impaired fasting glucose(IFG),7 cases of IFG complicated with impaired glucose tolerance(IGT) and 252 cases of impaired glucose tolerance(IGT).The levels of the gestational fasthg plasma glucose(FPG),2h plasma glucose(2hPG),and 3h plasma glucose(3hPG) in GDM patients with abnormal postpartum glucose metabolism were higher than those in normal group(P<0.01),but the neonatal body weight was lower than that in normal group(P<0.01).The univariate analysis showed the gestational FPG,2hPG,3hPG and neonatal body weight were the influencing factors of the GDM patients with abnormal postpartum glucose metabolism.The multivariate analysis showed that the gestational FPG,2hPG and 3hPG were the independent risk factor of abnormal postpartum glucose metabolism.The higher the value of FPG(OR=3.528),2hPG(OR=1.579) and 3hPG(OR=1.655) were,the higher the risk of abnormal postpartum glucose metabolism was.Conclusions:The postpartum abnormal glucose metabolism can be found in partial GDM patients,which is related to the result of OGTT.The pertinent following up administration and preventing measures should be developed.
2017, 42(7): 894-896.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.017
Abstract:
Objective:To explore the preventive effects of preoxygenation on hyoxemia in obese patients treated with painless colonoscopy.Methods:A total of 128 patients with body mass index≥30 kg/m2 treated with painless colonoscopy were equally divided into the preoxygenation group and control group.The preoxygenation group were treated with high flux inhalating oxygen for 3 to 5 mins before anesthesia,while the control group took natural breathing.The levels of blood oxygen saturation(SpO2),mean arterial pressure and heart rate between two groups were compared in different time-points.The cases of SpO2 decline range during examination,examination time and total quantity of propofol administration between two groups were compared.Results:The levels of SpO2 before anesthesia,after 1 and 3 mins of colonoscopy,and at the end of examination in preoxygenation group were obviously higher than that in control group(P<0.01).The proportion of SpO2<95% and examination time in preoxygenation group were obviously less than those in control group(P<0.05).Conclusions:The preoxygenation in obese patients before painless colonoscopy can effectively improve the reserving oxygen capacity,reduce the risk of hypoxemia,and shorten the time of colonoscopy.
Objective:To explore the preventive effects of preoxygenation on hyoxemia in obese patients treated with painless colonoscopy.Methods:A total of 128 patients with body mass index≥30 kg/m2 treated with painless colonoscopy were equally divided into the preoxygenation group and control group.The preoxygenation group were treated with high flux inhalating oxygen for 3 to 5 mins before anesthesia,while the control group took natural breathing.The levels of blood oxygen saturation(SpO2),mean arterial pressure and heart rate between two groups were compared in different time-points.The cases of SpO2 decline range during examination,examination time and total quantity of propofol administration between two groups were compared.Results:The levels of SpO2 before anesthesia,after 1 and 3 mins of colonoscopy,and at the end of examination in preoxygenation group were obviously higher than that in control group(P<0.01).The proportion of SpO2<95% and examination time in preoxygenation group were obviously less than those in control group(P<0.05).Conclusions:The preoxygenation in obese patients before painless colonoscopy can effectively improve the reserving oxygen capacity,reduce the risk of hypoxemia,and shorten the time of colonoscopy.
2017, 42(7): 897-899.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.018
Abstract:
Objective:To investigate the efficacy of the percutaneous minimally invasive pedicle screw rod internal fixation in the treatment of thoracolumbar fractures.Methods:Ninety-eight patients with thoracolumbar fractures were divided into the observation group and control group,were treated with percutaneous minimally invasive and traditional opening pedicle screw rod internal fixation,respectively.The curative effects between two groups were compared.Results:The operation time,incision length,bleeding volume,postoperative drainage volume and postoperative visual analogue scale 1 day score in observation group were significantly less than those in control group(P<0.01).The differences of the percentage of vertebral anterior height,postoperative 1 week and 1 year sagittal plane Cobb angle,and Oswestry disability index between two groups were not statistically significant(P>0.05).Conclusions:The percutaneous minimally invasive pedicle screw rod internal fixation in the treatment of thoracolumbar fractures is effective,which is less trauma,quick recovery and light pain,and worthy of clinical application
Objective:To investigate the efficacy of the percutaneous minimally invasive pedicle screw rod internal fixation in the treatment of thoracolumbar fractures.Methods:Ninety-eight patients with thoracolumbar fractures were divided into the observation group and control group,were treated with percutaneous minimally invasive and traditional opening pedicle screw rod internal fixation,respectively.The curative effects between two groups were compared.Results:The operation time,incision length,bleeding volume,postoperative drainage volume and postoperative visual analogue scale 1 day score in observation group were significantly less than those in control group(P<0.01).The differences of the percentage of vertebral anterior height,postoperative 1 week and 1 year sagittal plane Cobb angle,and Oswestry disability index between two groups were not statistically significant(P>0.05).Conclusions:The percutaneous minimally invasive pedicle screw rod internal fixation in the treatment of thoracolumbar fractures is effective,which is less trauma,quick recovery and light pain,and worthy of clinical application
2017, 42(7): 899-900,903.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.019
Abstract:
Objective:To evaluate the efficacy and safety of different dosing frequency recombinant human thrombopoietin(rhTPO) in the treatment of postchemotherapy thrombocytopenia in acute leukemia patients.Methods:Forty acute leukemia patients complicated with thrombocytopenia were randomly divided into the group A and group B.The group A were contiously treated with 15 000 U rhTPO,one time a day for 14 times,and the group B were treated with 15000 U rhTPO,one time two days for 7 times.The clinical effects and adverse reactions between two groups were compared.Results:After treatment,the level of platelet(PLT) in group A was significantly higher than that in group B(P<0.01).The duration time of PLT<50×109/L,and the recovery time of PLT from 50×109/L arriving at 75×109/L or 100×109/L in group A were significantly less than those in group B(P<0.01).No serious adverse events occurred in two groups.Conclusions:Compared with alternate-day dosing,the continuous dosing plays better enhancing effect in the PLT level.The difference of the reducing the risk of bleeding and medication safety between two groups is not obvious.
Objective:To evaluate the efficacy and safety of different dosing frequency recombinant human thrombopoietin(rhTPO) in the treatment of postchemotherapy thrombocytopenia in acute leukemia patients.Methods:Forty acute leukemia patients complicated with thrombocytopenia were randomly divided into the group A and group B.The group A were contiously treated with 15 000 U rhTPO,one time a day for 14 times,and the group B were treated with 15000 U rhTPO,one time two days for 7 times.The clinical effects and adverse reactions between two groups were compared.Results:After treatment,the level of platelet(PLT) in group A was significantly higher than that in group B(P<0.01).The duration time of PLT<50×109/L,and the recovery time of PLT from 50×109/L arriving at 75×109/L or 100×109/L in group A were significantly less than those in group B(P<0.01).No serious adverse events occurred in two groups.Conclusions:Compared with alternate-day dosing,the continuous dosing plays better enhancing effect in the PLT level.The difference of the reducing the risk of bleeding and medication safety between two groups is not obvious.
2017, 42(7): 901-903.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.020
Abstract:
Objective:To investigate the necessity of indwelling ureteral stent after middle-lower ureteral calculi treated with ureteroscopic lithotripsy.Methods:One hundred and four middle-lower ureteral calculi patients treated with ureteroscopic lithotripsy were divided into the group A(52 cases,non-indwelling ureteral stent) and group B(52 cases,indwelling ureteral stent).The age,sex,stone size,operative time,postoperative pain,lower urinary tract symptom,gross hematuria,urinary tract infection,stone clearance rate and occurrence rate of postoperative ureteral stenosis between two groups were compared.Results:The differences of the postoperative pain,lower urinary tract symptom,urinary tract infection,gross hematuria,stone clearance rate and occurrence rate of postoperative ureteral stenosis between two groups were not statistically significant(P>0.05).Conclusions:Non-indwelling ureteral stent in middle-lower ureteral calculi treated with ureteroscopic lithotripsy is safe and feasible,which can be decided according to the concrete conditions in clinic.
Objective:To investigate the necessity of indwelling ureteral stent after middle-lower ureteral calculi treated with ureteroscopic lithotripsy.Methods:One hundred and four middle-lower ureteral calculi patients treated with ureteroscopic lithotripsy were divided into the group A(52 cases,non-indwelling ureteral stent) and group B(52 cases,indwelling ureteral stent).The age,sex,stone size,operative time,postoperative pain,lower urinary tract symptom,gross hematuria,urinary tract infection,stone clearance rate and occurrence rate of postoperative ureteral stenosis between two groups were compared.Results:The differences of the postoperative pain,lower urinary tract symptom,urinary tract infection,gross hematuria,stone clearance rate and occurrence rate of postoperative ureteral stenosis between two groups were not statistically significant(P>0.05).Conclusions:Non-indwelling ureteral stent in middle-lower ureteral calculi treated with ureteroscopic lithotripsy is safe and feasible,which can be decided according to the concrete conditions in clinic.
2017, 42(7): 904-905,909.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.021
Abstract:
Objective:To investigate the therapeutic effects of joint cavity ozone injection combined with rehabilitation therapy on knee osteoarthritis.Methods:Eighty knee osteoarthritis patients were divided into the observation group and control group according to random number table method(40 cases each group).The control group was treated with rehabilitation therapy,and the observation group were additionally treated with ozone injection based on the control group.The VAS pain scores,Lequesne index and therapeutic effects between two groups were compared before and after treatment.Results:After treatment,the VAS score and Lequesne score in two groups increased,the increasing degree of which in observation group was significantly higher than that in control group(P<0.01).The effective rate in observation group(90.0%) was higher than that in control group(65.0%)(P<0.05).Conclusions:The joint cavity ozone injection combined with rehabilitation in the treatment of knee osteoarthritis is good effect,which can relieve the pain of patients,and improve the knee function of patients to a certain degree.
Objective:To investigate the therapeutic effects of joint cavity ozone injection combined with rehabilitation therapy on knee osteoarthritis.Methods:Eighty knee osteoarthritis patients were divided into the observation group and control group according to random number table method(40 cases each group).The control group was treated with rehabilitation therapy,and the observation group were additionally treated with ozone injection based on the control group.The VAS pain scores,Lequesne index and therapeutic effects between two groups were compared before and after treatment.Results:After treatment,the VAS score and Lequesne score in two groups increased,the increasing degree of which in observation group was significantly higher than that in control group(P<0.01).The effective rate in observation group(90.0%) was higher than that in control group(65.0%)(P<0.05).Conclusions:The joint cavity ozone injection combined with rehabilitation in the treatment of knee osteoarthritis is good effect,which can relieve the pain of patients,and improve the knee function of patients to a certain degree.
2017, 42(7): 906-909.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.022
Abstract:
Objective:To investigate the clinical effects of transvaginal uterine scarpregnancy resection.Methods:Twenty-five patients with scarpregnancy after cesarean section were randomly divided into the control group(17 cases) and observation group(8 cases).The control group were treated with uterine artery methotrexate embolization combined with uterine curettage guilded by B-ultrasonography within 24 hours,and the observation group were treated with transvaginal uterine scarpregnancy resection.The clinical effects between two groups were compared.Results:Twenty-five patients were successfully operated and discharged.The average operation time,hospital expense and postoperative normal menstrual time in observation group were lower than those in control group(P<0.01).The intraoperative blood loss in observation group were higher than that in control group(P<0.01).The differences of the average hospital stay and postoperative blood β-hCG recovery time between two groups were not statistically significant(P>0.05).The results of B ultrasound after 2 weeks of operation showed that the incidence rate of scar mass in observation group(0.00%) was lower than that in control group(52.94%)(P<0.05).There was no statistical significance in the abnormal rate of menstruation between two groups(P>0.05).Conclusions:The transvaginal uterine scarpregnancy resection can one-time remove lesions and scar diverticulum,and is minimally invasive,easy to operate and less postoperative complications,which is worthy of clinical promotion.
Objective:To investigate the clinical effects of transvaginal uterine scarpregnancy resection.Methods:Twenty-five patients with scarpregnancy after cesarean section were randomly divided into the control group(17 cases) and observation group(8 cases).The control group were treated with uterine artery methotrexate embolization combined with uterine curettage guilded by B-ultrasonography within 24 hours,and the observation group were treated with transvaginal uterine scarpregnancy resection.The clinical effects between two groups were compared.Results:Twenty-five patients were successfully operated and discharged.The average operation time,hospital expense and postoperative normal menstrual time in observation group were lower than those in control group(P<0.01).The intraoperative blood loss in observation group were higher than that in control group(P<0.01).The differences of the average hospital stay and postoperative blood β-hCG recovery time between two groups were not statistically significant(P>0.05).The results of B ultrasound after 2 weeks of operation showed that the incidence rate of scar mass in observation group(0.00%) was lower than that in control group(52.94%)(P<0.05).There was no statistical significance in the abnormal rate of menstruation between two groups(P>0.05).Conclusions:The transvaginal uterine scarpregnancy resection can one-time remove lesions and scar diverticulum,and is minimally invasive,easy to operate and less postoperative complications,which is worthy of clinical promotion.
2017, 42(7): 910-912.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.023
Abstract:
Objective:To observe the clinical effects between the CO2 laser microsurgery and traditional self-retaining laryngoscope in the treatment of throat benign and precancerous lesions.Methods:Forty-two patients with throat benign and precancerous lesions were divided into the CO2 laser group and common group according to the treatment method,and the clinical effects between two groups were compared.Results:All patients were followed up for 3 months,and the difference of total effective rate between two groups was not statistically significant(P>0.05).One case with laryngeal squamous epithelial dysplasia complicated with vocal cord adhesion in CO2 laser group recurred,and treated with laser microsurgery again.The postoperative recurrence in two cases with laryngeal squamous epithelial dysplasia,and incomplete closure of vocal cord in 1 case with vocal polyp were found in common group.For other cases,the lesions were completed removed,the throat function was good,and no serious complications occurred.Conclusions:The clinical effect of vocal polyp and precancerous lesions treated with CO2 laser microsurgery is effective,which can preserve the laryngeal structure and function,is an important means in treating throat disease.The operation method is selected according to the parent's condition.
Objective:To observe the clinical effects between the CO2 laser microsurgery and traditional self-retaining laryngoscope in the treatment of throat benign and precancerous lesions.Methods:Forty-two patients with throat benign and precancerous lesions were divided into the CO2 laser group and common group according to the treatment method,and the clinical effects between two groups were compared.Results:All patients were followed up for 3 months,and the difference of total effective rate between two groups was not statistically significant(P>0.05).One case with laryngeal squamous epithelial dysplasia complicated with vocal cord adhesion in CO2 laser group recurred,and treated with laser microsurgery again.The postoperative recurrence in two cases with laryngeal squamous epithelial dysplasia,and incomplete closure of vocal cord in 1 case with vocal polyp were found in common group.For other cases,the lesions were completed removed,the throat function was good,and no serious complications occurred.Conclusions:The clinical effect of vocal polyp and precancerous lesions treated with CO2 laser microsurgery is effective,which can preserve the laryngeal structure and function,is an important means in treating throat disease.The operation method is selected according to the parent's condition.
2017, 42(7): 913-915.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.024
Abstract:
Objective:To investigate the association between neutrophil/lymphocyte ratio(NLR) and lower limb atherosclerosis in patients with type 2 diabetes mellitus(T2DM).Methods:Fifty-three patients with T2DM whose lower limb blood vessel was examined using color Doppler ultrasono graphy were divided into the lesion group(36 cases with lower limb atherosclerosis) and nonlesion group(17 cases without lower limb atherosclerosis).The lesion group was subdivided into the group A(crude),group B(thickening or plaques) and group C(thickening and plaques) according to the pathological change.The correlated clinical indexes and NLR between these groups were compared and analyzed using logistic regression analysis.Results:The levels of glycosylated hemoglobin,triglyceride(TG) and C-reative protein(CRP),neutrophil count,lymphocyte count and NLR in lesion group were significantly higher than those in nonlesion group(P<0.01).The differences of NLR between A,B and C groups were statistically significant(P<0.01),the NLR in group C was significantly higher than that in group A and group B(P<0.01),and the NLR in group B was higher than that in group A(P<0.05).Logistic multivariate regression analysis showed that the TG,CRP and NLR were the independent risk factors of lower limb atherosclerosis in patients with T2DM(P<0.05).Conclusions:The TG,CRP and NLR are closely correlated with the lower limb atherosclerosis in patients with T2DM,and the NLR has predictive values in diagnosing the disease.
Objective:To investigate the association between neutrophil/lymphocyte ratio(NLR) and lower limb atherosclerosis in patients with type 2 diabetes mellitus(T2DM).Methods:Fifty-three patients with T2DM whose lower limb blood vessel was examined using color Doppler ultrasono graphy were divided into the lesion group(36 cases with lower limb atherosclerosis) and nonlesion group(17 cases without lower limb atherosclerosis).The lesion group was subdivided into the group A(crude),group B(thickening or plaques) and group C(thickening and plaques) according to the pathological change.The correlated clinical indexes and NLR between these groups were compared and analyzed using logistic regression analysis.Results:The levels of glycosylated hemoglobin,triglyceride(TG) and C-reative protein(CRP),neutrophil count,lymphocyte count and NLR in lesion group were significantly higher than those in nonlesion group(P<0.01).The differences of NLR between A,B and C groups were statistically significant(P<0.01),the NLR in group C was significantly higher than that in group A and group B(P<0.01),and the NLR in group B was higher than that in group A(P<0.05).Logistic multivariate regression analysis showed that the TG,CRP and NLR were the independent risk factors of lower limb atherosclerosis in patients with T2DM(P<0.05).Conclusions:The TG,CRP and NLR are closely correlated with the lower limb atherosclerosis in patients with T2DM,and the NLR has predictive values in diagnosing the disease.
2017, 42(7): 916-918.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.025
Abstract:
Objective:To compare the clinical effects between regional citrate anticoagulation(RCA) and heparin anticoagulation in severe patients treated with continuous venous-venous hemofiltration(CVVH).Methods:The clinical data of 45 severe patients treated with CVVH were retrospectively analyzed.The patients were divided into the RCA-CVVH group(RCA group,25 cases) and heparin anticoagulation CVVH group(heparin group,20 cases) according to the anticoagulation method.The differences of the coagulant function,internal environment,renal function,bleeding complication and filter longevity before and after treatment between two groups were compared.Results:The differences of the activated partial thromboplastin time(APTT) and prothrombin time(PT) in RCA-CVVH group between before and after treatment were not statistically significant(P>0.05),and the levels of the Cr and BUN in RCA-CVVH group significantly decreased after treatment(P<0.01).Compared before treatment,the APTT and PT in heparin-CVVH group prolonged after treatment(P<0.01),and the levels of the Cr and BUN in heparin-CVVH group significantly decreased after treatment(P<0.01).Compared before treatment,the levels of Na+ and Ca2+ in RCA group decreased after treatment(P<0.01),the changes of the level of HCO3- and pH value in RCA group were not obvious after treatment(P>0.05).Compared before treatment,the changes of the levels of Na+,Ca2+ and HCO3-,and pH value in heparin group were not obvious after treatment(P>0.05).The secondary hemorrhage in RCA group(1 cases,4%) was lower than that in heparin group(3 cases,15%)(P<0.05).The filter longevity in RCA group[(35.26±7.60)h] was longer than that in heparin group[(20.75±5.3)h](P<0.01).Conclusions:The filtration effect of RCA-CVVH is similar to heparin,which is less effect on the coagulation function,does not increase the bleeding risk in severe patients,can prolong the filter longevity,and has better security and practicability.
Objective:To compare the clinical effects between regional citrate anticoagulation(RCA) and heparin anticoagulation in severe patients treated with continuous venous-venous hemofiltration(CVVH).Methods:The clinical data of 45 severe patients treated with CVVH were retrospectively analyzed.The patients were divided into the RCA-CVVH group(RCA group,25 cases) and heparin anticoagulation CVVH group(heparin group,20 cases) according to the anticoagulation method.The differences of the coagulant function,internal environment,renal function,bleeding complication and filter longevity before and after treatment between two groups were compared.Results:The differences of the activated partial thromboplastin time(APTT) and prothrombin time(PT) in RCA-CVVH group between before and after treatment were not statistically significant(P>0.05),and the levels of the Cr and BUN in RCA-CVVH group significantly decreased after treatment(P<0.01).Compared before treatment,the APTT and PT in heparin-CVVH group prolonged after treatment(P<0.01),and the levels of the Cr and BUN in heparin-CVVH group significantly decreased after treatment(P<0.01).Compared before treatment,the levels of Na+ and Ca2+ in RCA group decreased after treatment(P<0.01),the changes of the level of HCO3- and pH value in RCA group were not obvious after treatment(P>0.05).Compared before treatment,the changes of the levels of Na+,Ca2+ and HCO3-,and pH value in heparin group were not obvious after treatment(P>0.05).The secondary hemorrhage in RCA group(1 cases,4%) was lower than that in heparin group(3 cases,15%)(P<0.05).The filter longevity in RCA group[(35.26±7.60)h] was longer than that in heparin group[(20.75±5.3)h](P<0.01).Conclusions:The filtration effect of RCA-CVVH is similar to heparin,which is less effect on the coagulation function,does not increase the bleeding risk in severe patients,can prolong the filter longevity,and has better security and practicability.
2017, 42(7): 919-921.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.026
Abstract:
Objective:To compare the clinical efficacy of tubular in the treatment of esophageal carcinoma.Methods:Forty-six patients with esophageal cancer(survival time more than 1 year) were divided into the tubular stomach group(26 cases) and full stomach group(20 cases) according to the digestive tract reconstruction way.The tubular stomach group and full stomach group were treated with tubular gastroesophageal anastomosis surgery and full gastroesophageal anastomosis surgery,respectively.The operation condition,lung function and quality of life before and after operation between two groups were compared.Results:The differences of the operative time,intraoperative blood loss,chest drainage and length of hospital stay between two groups were not statistically significant(P>0.05).The incidence rates of pulmonary complications and reflux esophagitis in tubular stomach group were lower than those in full stomach group(P<0.05).Compared with before operation,the MMV%,FEV1% and VC% in two groups significantly decreased,and the decreasing degree of which in full stomach group was more obvious after operation(P<0.01).The scores of quality of life of 6 and 12 months in tubular stomach group were significantly higher than that of 3 weeks after operation,and significantly higher than that of same postoperative period in full stomach group(P<0.01).Conclusions:Compared with full gastroesophageal anastomosis surgery,the tubular gastroesophaged anastomosis surgery can effectively reduce the reflux esophagitis and incidence rate of pulmonary complications,has little effect on postoperative pulmonary function and high short-term quality of life.
Objective:To compare the clinical efficacy of tubular in the treatment of esophageal carcinoma.Methods:Forty-six patients with esophageal cancer(survival time more than 1 year) were divided into the tubular stomach group(26 cases) and full stomach group(20 cases) according to the digestive tract reconstruction way.The tubular stomach group and full stomach group were treated with tubular gastroesophageal anastomosis surgery and full gastroesophageal anastomosis surgery,respectively.The operation condition,lung function and quality of life before and after operation between two groups were compared.Results:The differences of the operative time,intraoperative blood loss,chest drainage and length of hospital stay between two groups were not statistically significant(P>0.05).The incidence rates of pulmonary complications and reflux esophagitis in tubular stomach group were lower than those in full stomach group(P<0.05).Compared with before operation,the MMV%,FEV1% and VC% in two groups significantly decreased,and the decreasing degree of which in full stomach group was more obvious after operation(P<0.01).The scores of quality of life of 6 and 12 months in tubular stomach group were significantly higher than that of 3 weeks after operation,and significantly higher than that of same postoperative period in full stomach group(P<0.01).Conclusions:Compared with full gastroesophageal anastomosis surgery,the tubular gastroesophaged anastomosis surgery can effectively reduce the reflux esophagitis and incidence rate of pulmonary complications,has little effect on postoperative pulmonary function and high short-term quality of life.
2017, 42(7): 922-925.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.027
Abstract:
Objective:To compare the curative effects between Wiltse approach and traditional approach combined with injured vertebrae fixation in the treatment of thoracolumbar fractures.Methods:A total of 45 patients with thoracolumbar fractures were divided into the observation group(n=22) and control group(n=23).The control group was treated with the traditional posterior midline approach combined with injured vertebrae fixation,and the observation group was treated with the Wiltse approach combined with injured vertebrae fixation.The operation time,intraoperative bleeding,anterior height of the vertebral body before and after operation,kyphose Cobbs angle and postoperative internal fixation,and loss of restoration in two groups were observed.Results:The operations in two groups were successful,and the incisions of all cases were primary healing.No nerve injury,internal fixation bent,loosing,rupture and lumber vertebra losing function were found.All cases were followed up for 12 to 18 months,and achieved the clinical goal of osseous healing.The difference of the operation time between two groups was not statistically significant(P>0.05).The intraoperative bleeding and postoperative drainage volume in observation group were significantly less than those in control group(P<0.01).After 2 weeks and 1 year of operation,the anterior height of the injury vertebral body in two groups was ignificantly higher than those of before operation(P<0.01),and the Cobbs angle in two groups was significantly lower than those of before operation(P<0.01).The differences of anterior height of the injury vertebral body and Cobbs angle before operation,and after 2 weeks and 1 year of operation between two groups were not statistically significant(P>0.05).Conclusions:The Wiltse approach combined with vertebrae fixation in the treatment of thoracolumbar fractures can effectively protect the spine posterior muscle,reduce the incidence of lumber vertebra losing function,and is minimally invasive and less bleeding.The injured vertebrae fixation can help to recover the vertebral body height and decrease the occurrence of internal fixation system losing function.
Objective:To compare the curative effects between Wiltse approach and traditional approach combined with injured vertebrae fixation in the treatment of thoracolumbar fractures.Methods:A total of 45 patients with thoracolumbar fractures were divided into the observation group(n=22) and control group(n=23).The control group was treated with the traditional posterior midline approach combined with injured vertebrae fixation,and the observation group was treated with the Wiltse approach combined with injured vertebrae fixation.The operation time,intraoperative bleeding,anterior height of the vertebral body before and after operation,kyphose Cobbs angle and postoperative internal fixation,and loss of restoration in two groups were observed.Results:The operations in two groups were successful,and the incisions of all cases were primary healing.No nerve injury,internal fixation bent,loosing,rupture and lumber vertebra losing function were found.All cases were followed up for 12 to 18 months,and achieved the clinical goal of osseous healing.The difference of the operation time between two groups was not statistically significant(P>0.05).The intraoperative bleeding and postoperative drainage volume in observation group were significantly less than those in control group(P<0.01).After 2 weeks and 1 year of operation,the anterior height of the injury vertebral body in two groups was ignificantly higher than those of before operation(P<0.01),and the Cobbs angle in two groups was significantly lower than those of before operation(P<0.01).The differences of anterior height of the injury vertebral body and Cobbs angle before operation,and after 2 weeks and 1 year of operation between two groups were not statistically significant(P>0.05).Conclusions:The Wiltse approach combined with vertebrae fixation in the treatment of thoracolumbar fractures can effectively protect the spine posterior muscle,reduce the incidence of lumber vertebra losing function,and is minimally invasive and less bleeding.The injured vertebrae fixation can help to recover the vertebral body height and decrease the occurrence of internal fixation system losing function.
2017, 42(7): 926-929.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.028
Abstract:
Objective:To investigate the clinical effects of unilateral percutaneous kyphoplasty(PKP) and vertebroplasty(PVP) in the treatment of the elders with osteoporotic vertebral compression fractures(OVCFs).Methods:Twenty-one elder patients with OVCFs(25 vertebras) and 20 elder patients with OVCFs(22 vertebras) were treated with PKP and PVP,respectively.The vertebral height and VAS scores in all cases were recorded and analyzed before and after operation,and during following-up period.Results:During the following-up,the VAS score in PVP group was higher than that in PKP group(P<0.05).The differences of VAS scores at all time-points were statistically significant(P<0.01),and the VAS scores in two groups decreased(before operation > after operation > during following-up)(P<0.01).The heights of anterior and middle edge of vertebra in PKP group were significantly higher than those in PVP group after operation(P<0.01).The heights of anterior and middle edge of vertebra in two groups after operation were significantly higher than those in two groups before operation(P<0.01).Conclusions:Compared with the PVP,the PKP is a more effective method in treating the elder OVCFs.
Objective:To investigate the clinical effects of unilateral percutaneous kyphoplasty(PKP) and vertebroplasty(PVP) in the treatment of the elders with osteoporotic vertebral compression fractures(OVCFs).Methods:Twenty-one elder patients with OVCFs(25 vertebras) and 20 elder patients with OVCFs(22 vertebras) were treated with PKP and PVP,respectively.The vertebral height and VAS scores in all cases were recorded and analyzed before and after operation,and during following-up period.Results:During the following-up,the VAS score in PVP group was higher than that in PKP group(P<0.05).The differences of VAS scores at all time-points were statistically significant(P<0.01),and the VAS scores in two groups decreased(before operation > after operation > during following-up)(P<0.01).The heights of anterior and middle edge of vertebra in PKP group were significantly higher than those in PVP group after operation(P<0.01).The heights of anterior and middle edge of vertebra in two groups after operation were significantly higher than those in two groups before operation(P<0.01).Conclusions:Compared with the PVP,the PKP is a more effective method in treating the elder OVCFs.
2017, 42(7): 932-934.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.030
Abstract:
Objective:To investigate the diagnostic value of myocardial enzyme combined with high sensitivity C-reactive protein(hs-CRP) in early hand-foot-mouth disease.Methods:Forty-two children with early hand-foot-mouth disease and 40 healthy children were divided into the observation group and control group,respectively.The levels of myocardial enzymes and hs-CRP in two groups were detected.Results:The levels of creatine kinase(CK),creatine kinase isoenzyme(CK-MB) and hs-CRP in observation group were significantly higher than those in control group(P<0.01).The levels of CK-MB and hs-CRP in high risk children in observation group were higher than those in control group(P<0.01 and P<0.05).The serum levels of CK and CK-MB in children with hand-foot-mouth disease were positively correlated with the level of hs-CRP(P<0.05).Conclusions:The diagnostic value of myocardial enzyme combined with hs-CRP in early hand-foot-mouth disease is high,which can be used in evaluating the disease diagnosis,and is worthy of promotion in clinic.
Objective:To investigate the diagnostic value of myocardial enzyme combined with high sensitivity C-reactive protein(hs-CRP) in early hand-foot-mouth disease.Methods:Forty-two children with early hand-foot-mouth disease and 40 healthy children were divided into the observation group and control group,respectively.The levels of myocardial enzymes and hs-CRP in two groups were detected.Results:The levels of creatine kinase(CK),creatine kinase isoenzyme(CK-MB) and hs-CRP in observation group were significantly higher than those in control group(P<0.01).The levels of CK-MB and hs-CRP in high risk children in observation group were higher than those in control group(P<0.01 and P<0.05).The serum levels of CK and CK-MB in children with hand-foot-mouth disease were positively correlated with the level of hs-CRP(P<0.05).Conclusions:The diagnostic value of myocardial enzyme combined with hs-CRP in early hand-foot-mouth disease is high,which can be used in evaluating the disease diagnosis,and is worthy of promotion in clinic.
2017, 42(7): 952-955.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.038
Abstract:
Objective:To investigate the value of 3.0T MRI apparent diffusion coefficient (ADC) in the diagnosis of prostate cancer,and its correlation with pathologic Gleason score and prostate specific antigen (PSA).Methods:The clinical data of 52 patients with prostate disease confirmed by pathology from August 2015 to March 2017 were retrospectively analyzed,including 22 cases of prostate cancer (PCa) and 30 cases of benign prostatic hyperplasia (BPH).So patients were routine MRI scan,b = 0,800 s / mm2 to establish the ADC and ADC lesions measured,according to the ADC value to identify the diagnosis of PCa and BPH.And to assess its association with pathologic Gleason score and PSA.Results:The average ADC of 52 patients with prostate disease was (1.028±0.310)×10-3 mm2/s,PCa patients and BPH patients with ADC average significant difference,respectively (0.788±0.204)×10-3mm2/s and (1.204±0.251)×10-3mm2/s.The area under the ROC curve of the ADC value is 0.903,which has a good diagnostic effect.According to the ROC curve to determine the ADC value of the best diagnostic value of 0.831,the sensitivity of 72.7%,specificity of 100.0%.There was a negative correlation between the ADC value and the PSA(r=-0.519,P<0.01),and the ADC value was negatively correlated with the Glseason score(r=-0.508,P<0.01).Conclusions:The quantitative evaluation of ADC value is valuable for the identification of benign and malignant benign prostatic lesions.The low risk and high risk prostate cancer can be used to evaluate the clinical stage of PCa and guide the clinical selection of appropriate treatment Program.
Objective:To investigate the value of 3.0T MRI apparent diffusion coefficient (ADC) in the diagnosis of prostate cancer,and its correlation with pathologic Gleason score and prostate specific antigen (PSA).Methods:The clinical data of 52 patients with prostate disease confirmed by pathology from August 2015 to March 2017 were retrospectively analyzed,including 22 cases of prostate cancer (PCa) and 30 cases of benign prostatic hyperplasia (BPH).So patients were routine MRI scan,b = 0,800 s / mm2 to establish the ADC and ADC lesions measured,according to the ADC value to identify the diagnosis of PCa and BPH.And to assess its association with pathologic Gleason score and PSA.Results:The average ADC of 52 patients with prostate disease was (1.028±0.310)×10-3 mm2/s,PCa patients and BPH patients with ADC average significant difference,respectively (0.788±0.204)×10-3mm2/s and (1.204±0.251)×10-3mm2/s.The area under the ROC curve of the ADC value is 0.903,which has a good diagnostic effect.According to the ROC curve to determine the ADC value of the best diagnostic value of 0.831,the sensitivity of 72.7%,specificity of 100.0%.There was a negative correlation between the ADC value and the PSA(r=-0.519,P<0.01),and the ADC value was negatively correlated with the Glseason score(r=-0.508,P<0.01).Conclusions:The quantitative evaluation of ADC value is valuable for the identification of benign and malignant benign prostatic lesions.The low risk and high risk prostate cancer can be used to evaluate the clinical stage of PCa and guide the clinical selection of appropriate treatment Program.
2017, 42(7): 956-959.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.039
Abstract:
Objective:To explore the value of MSCT post-processing technique in the diagnosis and preoperative evaluation of pancreatic cancer.Methods:The CT image and clinical data of 22 patients with pancreatic carcinoma were retrospectively analyzed.The infiltrating range of around organizational structure and distant metastasis of tumor based on tumor localization were observed using triple-phased scanning of contrast enhanced MSCT and post-processing technique.The preoperative assessment of 12 pancreatic cancer patients with major vascular invasion were compared with surgical outcome.Results:Among 22 cases,the peripheral vascular invasion in 19 cases,gastric and duodenal wall invasion in 4 cases,lymph node metastasis in 6 cases and hepatic or splenic metastasis in 11 cases were identified.The assessment accuracy in major vascular invasion was 88.9% by MSCT.Conclusions:The contrast enhanced MSCT combined with post-processing technique can accurately diagnose the pancreatic carcinoma,which can provide an important value in preoperative evaluation in clinic.
Objective:To explore the value of MSCT post-processing technique in the diagnosis and preoperative evaluation of pancreatic cancer.Methods:The CT image and clinical data of 22 patients with pancreatic carcinoma were retrospectively analyzed.The infiltrating range of around organizational structure and distant metastasis of tumor based on tumor localization were observed using triple-phased scanning of contrast enhanced MSCT and post-processing technique.The preoperative assessment of 12 pancreatic cancer patients with major vascular invasion were compared with surgical outcome.Results:Among 22 cases,the peripheral vascular invasion in 19 cases,gastric and duodenal wall invasion in 4 cases,lymph node metastasis in 6 cases and hepatic or splenic metastasis in 11 cases were identified.The assessment accuracy in major vascular invasion was 88.9% by MSCT.Conclusions:The contrast enhanced MSCT combined with post-processing technique can accurately diagnose the pancreatic carcinoma,which can provide an important value in preoperative evaluation in clinic.
2017, 42(7): 960-962.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.040
Abstract:
Objective:The purpose of this study was to explore the value of low-dose spiral CT scanning in the diagnosis of secondary pulmonary tuberculosis.Methods:A total of 50 adult patients with secondary pulmonary tuberculosis were randomly selected from August to October in our hospital.Patients were initially examined with a conventional dose of 100 mAs.According to the Body Mass Index (BMI),the patients were divided into thin,medium,obese three kinds of patients,respectively,the application of 30 mAs,40 mAs,50 mAs review.Compared with conventional dose 100 mAs,The low dose group was the test group,Comparison of chest wall muscle,lung CT value,noise(SD)size.Compare the iconography-signs showed of the two groups Patients.Results:Conventional dose group CT volume dose index (CTDIvol) was 11.2 mGy,dose-length product(DLP)was(363.16±36.09)mGy·cm.Low dose group CTDI was(14.90±0.78)mGy,DLP was(159.41±30.22)mGy·cm,the difference was statistically significant(P<0.05).There was no significant difference in the CT and SD values between the two groups of patients with chest wall(P>0.05).The SD value of chest wall muscle in low dose group was significantly higher than that in conventional dose group,and the difference was statistically significant(P<0.05).There was no significant difference in the two groups of patients with tree bud syndrome,lung real change and grinding glass,nodules,strips,mesh,cavity,mediastinal lymph nodes,pleural thickening and adhesion,pleural effusion,calcification lesions(P>0.05).Conclusions:There was enormous clinical value of Low-dose CT in the diagnosis of secondary pulmonary tuberculosis, and it should be used in clinic.
Objective:The purpose of this study was to explore the value of low-dose spiral CT scanning in the diagnosis of secondary pulmonary tuberculosis.Methods:A total of 50 adult patients with secondary pulmonary tuberculosis were randomly selected from August to October in our hospital.Patients were initially examined with a conventional dose of 100 mAs.According to the Body Mass Index (BMI),the patients were divided into thin,medium,obese three kinds of patients,respectively,the application of 30 mAs,40 mAs,50 mAs review.Compared with conventional dose 100 mAs,The low dose group was the test group,Comparison of chest wall muscle,lung CT value,noise(SD)size.Compare the iconography-signs showed of the two groups Patients.Results:Conventional dose group CT volume dose index (CTDIvol) was 11.2 mGy,dose-length product(DLP)was(363.16±36.09)mGy·cm.Low dose group CTDI was(14.90±0.78)mGy,DLP was(159.41±30.22)mGy·cm,the difference was statistically significant(P<0.05).There was no significant difference in the CT and SD values between the two groups of patients with chest wall(P>0.05).The SD value of chest wall muscle in low dose group was significantly higher than that in conventional dose group,and the difference was statistically significant(P<0.05).There was no significant difference in the two groups of patients with tree bud syndrome,lung real change and grinding glass,nodules,strips,mesh,cavity,mediastinal lymph nodes,pleural thickening and adhesion,pleural effusion,calcification lesions(P>0.05).Conclusions:There was enormous clinical value of Low-dose CT in the diagnosis of secondary pulmonary tuberculosis, and it should be used in clinic.
2017, 42(7): 963-967.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.041
Abstract:
Objective:To explore the mediating role of the prosocial tendency in between voluntary motivation and voluntary behavior.Methods:Three hundred and fifty-five medical student volunteers were investigated using the general data questionnaire,prosocial tendency scale,voluntary functional motivation scale and voluntary behavior questionnaire.The data were analyzed,and the structural equation model were constructed.Results:Among the six subscales of voluntary functional motivation,the scores of the self-enhancement motivation,value-expression motivation,social communication motivation,learning and understanding motivation,career motivation and self-protect motivation were 5.301,5.244,5.239,5.228,4.999 and 4.982,respectively.Among the six dimensions of pro-social tendency,the scores of altruistic tendency,opening tendency,obedience tendency,anonymous tendency,emotional tendency and emergency tendency were 3.987,3.954,3.891,3.812,3.761 and 3.754,respectively.There were significantly positive correlations between the six dimensions of voluntary functional motivation,total scale of voluntary functional motivation,six dimensions of prosocial tendencies,total scale of prosocial tendency and voluntary behaviors(P<0.01).Prosocial tendency played a partial mediating effect in between voluntary functional motivation and voluntary behavior.The total effect value of the voluntary functional motivation on voluntary behavior was 0.649,the effect value accounted for 38.51% of the total effect value.Conclusions:Voluntary functional motivation and prosocial tendency can positively predict the voluntary behavior.To strengthen social education and enhance the level of prosocial tendency of students can help to promote the healthy development of the medical students' personality,promote more prosocial behavior of medical students and develop the medical volunteer services.
Objective:To explore the mediating role of the prosocial tendency in between voluntary motivation and voluntary behavior.Methods:Three hundred and fifty-five medical student volunteers were investigated using the general data questionnaire,prosocial tendency scale,voluntary functional motivation scale and voluntary behavior questionnaire.The data were analyzed,and the structural equation model were constructed.Results:Among the six subscales of voluntary functional motivation,the scores of the self-enhancement motivation,value-expression motivation,social communication motivation,learning and understanding motivation,career motivation and self-protect motivation were 5.301,5.244,5.239,5.228,4.999 and 4.982,respectively.Among the six dimensions of pro-social tendency,the scores of altruistic tendency,opening tendency,obedience tendency,anonymous tendency,emotional tendency and emergency tendency were 3.987,3.954,3.891,3.812,3.761 and 3.754,respectively.There were significantly positive correlations between the six dimensions of voluntary functional motivation,total scale of voluntary functional motivation,six dimensions of prosocial tendencies,total scale of prosocial tendency and voluntary behaviors(P<0.01).Prosocial tendency played a partial mediating effect in between voluntary functional motivation and voluntary behavior.The total effect value of the voluntary functional motivation on voluntary behavior was 0.649,the effect value accounted for 38.51% of the total effect value.Conclusions:Voluntary functional motivation and prosocial tendency can positively predict the voluntary behavior.To strengthen social education and enhance the level of prosocial tendency of students can help to promote the healthy development of the medical students' personality,promote more prosocial behavior of medical students and develop the medical volunteer services.
2017, 42(7): 968-970,974.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.042
Abstract:
Objective:To investigate nurses to participate in volunteer service motivation status and its influencing factors.Methods:This study used the self-made questionnaire of general information and volunteers function scale of a city of 242 on-the-job nurses in third rate synthetic hospital to investigate.Results:The different cultural degree of the nurse in the social dimension score difference was statistically significant(P<0.05).Different titles of the nurse in protecting dimension score difference was statistically significant(P<0.05).Different department nurses to participate in volunteer service motivation overall score differences statistically significant(P<0.01).The motivation of different department nurses to participate in volunteer service in value,the understanding,strengthen,professional,social,and protect each dimension score difference was statistically significant(P<0.01).Conclusions:Nurses,clear,participate in volunteer service motivation overall positive tendency.Different cultural degree,nurse their needs and work busy all affect the motivation of nurses to participate in volunteer service.Hope that through the joint efforts of hospital,nurses,improve the enthusiasm of nurses to participate in volunteer service activities.
Objective:To investigate nurses to participate in volunteer service motivation status and its influencing factors.Methods:This study used the self-made questionnaire of general information and volunteers function scale of a city of 242 on-the-job nurses in third rate synthetic hospital to investigate.Results:The different cultural degree of the nurse in the social dimension score difference was statistically significant(P<0.05).Different titles of the nurse in protecting dimension score difference was statistically significant(P<0.05).Different department nurses to participate in volunteer service motivation overall score differences statistically significant(P<0.01).The motivation of different department nurses to participate in volunteer service in value,the understanding,strengthen,professional,social,and protect each dimension score difference was statistically significant(P<0.01).Conclusions:Nurses,clear,participate in volunteer service motivation overall positive tendency.Different cultural degree,nurse their needs and work busy all affect the motivation of nurses to participate in volunteer service.Hope that through the joint efforts of hospital,nurses,improve the enthusiasm of nurses to participate in volunteer service activities.
2017, 42(7): 971-974.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.043
Abstract:
Objective:To investigate and analyze the motivation of participating voluntary service in medical undergraduates.Methods:Three hundred medical college students were investigated using the voluntary motivation scale by the method of cluster sampling.Results:Among 300 medical students,159 students participated the voluntary service activities(86.3%),and 41 students did not participate in the voluntary service activities(13.7%).The scores of the value expression,career,social interaction,learning understanding,self enhancement and volunteer motivation in grade 3 students were higher than those in Grade 1 students(P<0.01).The total scores of the self-protection,social interaction and voluntary motivation in male students were higher than those in female students(P<0.05 to P<0.01).After entering the university,the score of the social interaction in good students was higher than that in medium students(P<0.05).The scores of the value expression,career,social interaction,learning understanding,self enhancement and volunteer motivation in rural students were higher than those in county students(P<0.05 to P<0.01).The scores of the learning,understanding and self enhancement in rural students were significantly higher than those in town students(P<0.01).The differences of the scores of the monthly income in each dimension and voluntary motivation were not statistically significant(P>0.05).Among 6 dimensions of volunteer motivation scale of medical students,the scores of learning understanding,self enhancement,value expression,career,social interaction and self-protection were 5.117,5.059,5.048,4.910,4.420 and 4.339 points,respectively,and the average score of which was 4 points.Conclusions:The diversification of the voluntary service motivation and using own professional advantage in medical students are the main choice of volunteer service.The diversification of participating volunteer service can enhance the ability of certain aspects and meet some needs of students.Meet the voluntary service motivation can also encourage students to participate the volunteer service activities.
Objective:To investigate and analyze the motivation of participating voluntary service in medical undergraduates.Methods:Three hundred medical college students were investigated using the voluntary motivation scale by the method of cluster sampling.Results:Among 300 medical students,159 students participated the voluntary service activities(86.3%),and 41 students did not participate in the voluntary service activities(13.7%).The scores of the value expression,career,social interaction,learning understanding,self enhancement and volunteer motivation in grade 3 students were higher than those in Grade 1 students(P<0.01).The total scores of the self-protection,social interaction and voluntary motivation in male students were higher than those in female students(P<0.05 to P<0.01).After entering the university,the score of the social interaction in good students was higher than that in medium students(P<0.05).The scores of the value expression,career,social interaction,learning understanding,self enhancement and volunteer motivation in rural students were higher than those in county students(P<0.05 to P<0.01).The scores of the learning,understanding and self enhancement in rural students were significantly higher than those in town students(P<0.01).The differences of the scores of the monthly income in each dimension and voluntary motivation were not statistically significant(P>0.05).Among 6 dimensions of volunteer motivation scale of medical students,the scores of learning understanding,self enhancement,value expression,career,social interaction and self-protection were 5.117,5.059,5.048,4.910,4.420 and 4.339 points,respectively,and the average score of which was 4 points.Conclusions:The diversification of the voluntary service motivation and using own professional advantage in medical students are the main choice of volunteer service.The diversification of participating volunteer service can enhance the ability of certain aspects and meet some needs of students.Meet the voluntary service motivation can also encourage students to participate the volunteer service activities.
2017, 42(7): 975-979.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.044
Abstract:
Objective:To investigate the motivation of the participating volunteer service of nurses in the tertiary hospitals,and explore the establishment of the volunteer service system of hospital and how to effectively carry out voluntary service activities for providing the basis in improving the hospital volunteer service activities.Methods:The voluntary service activities of 191 nurses in a tertiary hospital were investigated using the motivation scale by random sampling method.Results:Among 191 respondents,74 people(38.7%) participated in volunteer service activities,and 117 people(61.3%) did not participate in volunteer service activities.The differences of the total scores of six dimensions and motivation of the volunteer motivation scale in different gender and marital status nurses were not statistically significant(P>0.05).The scores of self-protection dimension in junior college nurses,technical secondary school nurse and bachelor degree or above nurses were gradually decreasing.The scores of social communication dimension in junior college nurses,bachelor degree or above nurses and technical secondary school nurse were gradually decreasing.The scores of self-protection,career and social communication dimensions in primary nurse,intermediate nurse and senior nurse or above were gradually decreasing(P<0.05).The six dimensions scores of volunteer motivation scale in 191 nurses from high to low were the value expression(4.896),understanding(4.830),self-enhancement(4.819),occupation career(4.576),social communciation(4.162) and self-protection(4.154),respectively.Conclusions:The volunteer service motivation of nurses has diverse characteristics,the nurses with different needs choose different types of volunteer service activities,but the frequency of participating in voluntary service activities is low,the content is relatively simple,and the popularity rate of voluntary service is low.The hospital can establish long-term volunteer service system,improve the volunteer training mechanism,strengthen volunteer service organization publicity,which can improve the frequency of popularity rate of volunteer service activities,and provide professional contribution to society.
Objective:To investigate the motivation of the participating volunteer service of nurses in the tertiary hospitals,and explore the establishment of the volunteer service system of hospital and how to effectively carry out voluntary service activities for providing the basis in improving the hospital volunteer service activities.Methods:The voluntary service activities of 191 nurses in a tertiary hospital were investigated using the motivation scale by random sampling method.Results:Among 191 respondents,74 people(38.7%) participated in volunteer service activities,and 117 people(61.3%) did not participate in volunteer service activities.The differences of the total scores of six dimensions and motivation of the volunteer motivation scale in different gender and marital status nurses were not statistically significant(P>0.05).The scores of self-protection dimension in junior college nurses,technical secondary school nurse and bachelor degree or above nurses were gradually decreasing.The scores of social communication dimension in junior college nurses,bachelor degree or above nurses and technical secondary school nurse were gradually decreasing.The scores of self-protection,career and social communication dimensions in primary nurse,intermediate nurse and senior nurse or above were gradually decreasing(P<0.05).The six dimensions scores of volunteer motivation scale in 191 nurses from high to low were the value expression(4.896),understanding(4.830),self-enhancement(4.819),occupation career(4.576),social communciation(4.162) and self-protection(4.154),respectively.Conclusions:The volunteer service motivation of nurses has diverse characteristics,the nurses with different needs choose different types of volunteer service activities,but the frequency of participating in voluntary service activities is low,the content is relatively simple,and the popularity rate of voluntary service is low.The hospital can establish long-term volunteer service system,improve the volunteer training mechanism,strengthen volunteer service organization publicity,which can improve the frequency of popularity rate of volunteer service activities,and provide professional contribution to society.
2017, 42(7): 979-982.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.045
Abstract:
Objective:To investigate the organizational identification and voluntary behavior of nurses in a tertiary hospital,and its relationship.Methods:Two hundred and forty-two nurses from tertiary hospital were investigated using "organizational identification scale" and "voluntary behavior questionnaire" according to the convenience cluster sampling method.Results:The participators included 88 nurses(36.4%) attending various volunteer activities and 154 nurses(63.6%) never taking part in volunteer activities.The scores of organizational identification and voluntary behavior were(31.83±5.27) and (2.20±1.09),respectively.The score of organizational identification in nursing managers was significantly higher than that in nurses(P<0.01),the score of organizational identification in more than or equal to 36 years old nurses was significantly higher than that in 26 to 35 years old nurses(P<0.01),the score of organizational identification in nurses with working time for 6 to 10 years was the lowest,and the score of organizational identification in nurse-in-charge and above title nurse was more than that in senior nurse(P<0.05).The score of voluntary behavior in nursing managers was significantly higher than that in nurses(P<0.01).The organizational identification of nurses was significantly positive correlation with voluntary behavior(r=0.230,P<0.01).Conclusions:The organizational identification of nurses from tertiary hospital is positive,and the voluntary behavior is not optimistic.Organizational identification plays a role on predicting the voluntary behavior.Nursing managers should strive to further improve the organizational identification of nurse,and encourage nurse to participate in the volunteer service activities.
Objective:To investigate the organizational identification and voluntary behavior of nurses in a tertiary hospital,and its relationship.Methods:Two hundred and forty-two nurses from tertiary hospital were investigated using "organizational identification scale" and "voluntary behavior questionnaire" according to the convenience cluster sampling method.Results:The participators included 88 nurses(36.4%) attending various volunteer activities and 154 nurses(63.6%) never taking part in volunteer activities.The scores of organizational identification and voluntary behavior were(31.83±5.27) and (2.20±1.09),respectively.The score of organizational identification in nursing managers was significantly higher than that in nurses(P<0.01),the score of organizational identification in more than or equal to 36 years old nurses was significantly higher than that in 26 to 35 years old nurses(P<0.01),the score of organizational identification in nurses with working time for 6 to 10 years was the lowest,and the score of organizational identification in nurse-in-charge and above title nurse was more than that in senior nurse(P<0.05).The score of voluntary behavior in nursing managers was significantly higher than that in nurses(P<0.01).The organizational identification of nurses was significantly positive correlation with voluntary behavior(r=0.230,P<0.01).Conclusions:The organizational identification of nurses from tertiary hospital is positive,and the voluntary behavior is not optimistic.Organizational identification plays a role on predicting the voluntary behavior.Nursing managers should strive to further improve the organizational identification of nurse,and encourage nurse to participate in the volunteer service activities.
2017, 42(7): 983-986.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.046
Abstract:
Objective:To investigate the effects of eCASH nursing model on postoperative delirium in elderly patients with hip surgery.Methods:Thirty elderly patients with hip surgery from August to November in 2016 and 32 elderly patients with hip surgery from December 2016 to March in 2017 were divided into the control group and observation group,respectively.The control group and observation group were treated with the routine postoperative nursing and eCASH nursing management,respectively.All cases were evaluated using Nu-DESC within postoperative 3 days.The delirious state,VAS scores at different time-points,hospitalization time,and incidence rates of nausea and vomitting and unplanned extubation between two groups were compared after operation.Results:The different degrees of pain in two groups were identified before operation,but the difference of which was not statistically significant(P>0.05).There was no delirium in the 2 groups before operation.The delirious scores in observation group after 24,48 and 72 hours of operation were significantly lower than those in control group(P<0.01).The VAS scores at different time-points of postoperation,hospitalization time and incidence rates of nausea and vomitting and unplanned extubation in observation group were significantly lower than those in control group(P<0.01).Conclusions:The eCASH nursing model and early effective analgesia can effectively reduce the occurrence of postoperative delirium,hospitalization time and incidence rates of postoperative nausea and vomiting and unplanned extubation,which can provide the effective basis in preventing the postoperative complications in elderly patients with hip surgery.
Objective:To investigate the effects of eCASH nursing model on postoperative delirium in elderly patients with hip surgery.Methods:Thirty elderly patients with hip surgery from August to November in 2016 and 32 elderly patients with hip surgery from December 2016 to March in 2017 were divided into the control group and observation group,respectively.The control group and observation group were treated with the routine postoperative nursing and eCASH nursing management,respectively.All cases were evaluated using Nu-DESC within postoperative 3 days.The delirious state,VAS scores at different time-points,hospitalization time,and incidence rates of nausea and vomitting and unplanned extubation between two groups were compared after operation.Results:The different degrees of pain in two groups were identified before operation,but the difference of which was not statistically significant(P>0.05).There was no delirium in the 2 groups before operation.The delirious scores in observation group after 24,48 and 72 hours of operation were significantly lower than those in control group(P<0.01).The VAS scores at different time-points of postoperation,hospitalization time and incidence rates of nausea and vomitting and unplanned extubation in observation group were significantly lower than those in control group(P<0.01).Conclusions:The eCASH nursing model and early effective analgesia can effectively reduce the occurrence of postoperative delirium,hospitalization time and incidence rates of postoperative nausea and vomiting and unplanned extubation,which can provide the effective basis in preventing the postoperative complications in elderly patients with hip surgery.
2017, 42(7): 987-989,992.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.047
Abstract:
Objective:To investigate the effects of daily sedation awakening combined with early functional exercise on patients with invasive mechanical ventilation in Intensive Care Unit.Methods:Forty-seven patients with invasive mechanical ventilation from 2013 to 2014 and 47 cases with invasive mechanical ventilation from 2015 to 2016 were divided into the control group and observation group,respectively.The control group and observation group were treated with routine nursing intervention and daily sedation awakening combined with early functional exercise,respectively.The mechanical ventilation time,ICU stay time,total hospitalization time,ventilator-associated pneumonia incidence,pipeline off event and mortality between two groups were compared.Results:The mechanical ventilation time,ICU stay time and total hospitalization time in observation group were shorter than those in control group(P<0.05 to P<0.01).The differences of the ventilator-associated pneumonia incidence,pipeline off event and mortality between two groups were not statistically significant(P>0.05).Conclusions:The daily sedation awakening combined with early functional exercise in treating the patients with invasive mechanical ventilation can short the mechanical ventilation time and ICU stay time,and promote the rehabilitation of patients in ICU.
Objective:To investigate the effects of daily sedation awakening combined with early functional exercise on patients with invasive mechanical ventilation in Intensive Care Unit.Methods:Forty-seven patients with invasive mechanical ventilation from 2013 to 2014 and 47 cases with invasive mechanical ventilation from 2015 to 2016 were divided into the control group and observation group,respectively.The control group and observation group were treated with routine nursing intervention and daily sedation awakening combined with early functional exercise,respectively.The mechanical ventilation time,ICU stay time,total hospitalization time,ventilator-associated pneumonia incidence,pipeline off event and mortality between two groups were compared.Results:The mechanical ventilation time,ICU stay time and total hospitalization time in observation group were shorter than those in control group(P<0.05 to P<0.01).The differences of the ventilator-associated pneumonia incidence,pipeline off event and mortality between two groups were not statistically significant(P>0.05).Conclusions:The daily sedation awakening combined with early functional exercise in treating the patients with invasive mechanical ventilation can short the mechanical ventilation time and ICU stay time,and promote the rehabilitation of patients in ICU.
2017, 42(7): 990-992.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.048
Abstract:
Objective:To observe the effects of the respiratory care management in the prevention of pulmonary infection in hepatic failure patients.Methods:One hundred and fifty-two patients with hepatic failure were divided into the prevention group and conventional group using a random number table method(76 cases each group).The prevention group were nursed with the additional staff responsible for respiratory care based on the routine nursing,and the nursing standard of care measure was formulated for all-round monitoring.The related mortality rate,lung infection rate,average length of hospital stay and consumption between two groups were compared.Results:Among the patients with lung infection,the ratio of related-infection death in prevention group and conventional group were 38.89% and 50.00%,respectively,and the difference of which was not statistically significant(P>0.05).Among all patients,the ratio of related-infection death in prevention group(9.21%) was significantly lower than that in conventional group(23.69%)(P<0.01).The lung infection rate in prevention group(23.68%) was significantly lower than that in conventional group(47.37%)(P<0.01).The length of hospital stay and cost in prevention group were less than those in conventional group(P<0.01).Conclusions:The respiratory care can prevent the lung infection,reduce infection and mortality rates,and shorten the hospitalization time and cost in patients with hepatic failure.
Objective:To observe the effects of the respiratory care management in the prevention of pulmonary infection in hepatic failure patients.Methods:One hundred and fifty-two patients with hepatic failure were divided into the prevention group and conventional group using a random number table method(76 cases each group).The prevention group were nursed with the additional staff responsible for respiratory care based on the routine nursing,and the nursing standard of care measure was formulated for all-round monitoring.The related mortality rate,lung infection rate,average length of hospital stay and consumption between two groups were compared.Results:Among the patients with lung infection,the ratio of related-infection death in prevention group and conventional group were 38.89% and 50.00%,respectively,and the difference of which was not statistically significant(P>0.05).Among all patients,the ratio of related-infection death in prevention group(9.21%) was significantly lower than that in conventional group(23.69%)(P<0.01).The lung infection rate in prevention group(23.68%) was significantly lower than that in conventional group(47.37%)(P<0.01).The length of hospital stay and cost in prevention group were less than those in conventional group(P<0.01).Conclusions:The respiratory care can prevent the lung infection,reduce infection and mortality rates,and shorten the hospitalization time and cost in patients with hepatic failure.
2017, 42(7): 993-997.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.049
Abstract:
Objective:To explore the effects of health education based on transtheoretical model on the recovery behavior in postoperative patients with breast cancer.Methods:Twenty-one standard-compliant patients from August to December 2014,and 23 cases standard-compliant patients from January to June 2015 were divided into the control group and observation group,respectively.The control group and observation group were implemented with routine health education and transtheoretical model health education,respectively.All patients were evaluated using the DASH and self-designed questionnaire after 10 days,1 month and 3 months of operation.Results:The DASH scores in observation group after 1 month and 3 months of operation were lower than that in control group(P<0.01 and P<0.05).The compliance score in observation group after 3 months of operation was higher than that in control group(P<0.05).With the time going by,the DASH score gradually decreased,the compliance gradually increased,and the differences of statistically significant(P<0.01).Conclusions:The health education based on transtheoretical model can improve the compliance of the recovery behavior,and promote the upper limb recovery,with the time going by,the effect is more significant.
Objective:To explore the effects of health education based on transtheoretical model on the recovery behavior in postoperative patients with breast cancer.Methods:Twenty-one standard-compliant patients from August to December 2014,and 23 cases standard-compliant patients from January to June 2015 were divided into the control group and observation group,respectively.The control group and observation group were implemented with routine health education and transtheoretical model health education,respectively.All patients were evaluated using the DASH and self-designed questionnaire after 10 days,1 month and 3 months of operation.Results:The DASH scores in observation group after 1 month and 3 months of operation were lower than that in control group(P<0.01 and P<0.05).The compliance score in observation group after 3 months of operation was higher than that in control group(P<0.05).With the time going by,the DASH score gradually decreased,the compliance gradually increased,and the differences of statistically significant(P<0.01).Conclusions:The health education based on transtheoretical model can improve the compliance of the recovery behavior,and promote the upper limb recovery,with the time going by,the effect is more significant.
2017, 42(7): 998-1000.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.050
Abstract:
Objective:To explore the application value of clinical nursing combined with home self-care in children with asthma.Methods:Sixty children with asthma were randomly divided into the control group and observation group(30 cases each group).The control group was nursed with routine method,and the observation was nursed with clinical nursing combined with home self-care.The effective rate of controlling asthma,recurrence rate of asthma,disappearance time of asthma symptom,and mean hospitalization time of patients between two groups were compared.Results:The effective rate of controlling asthma in observation group(96.67%) was significantly higher than that in control group(63.33%)(P<0.01).The recurrence rate of asthma in observation group(6.67%) was lower than that in control group(26.67%)(P<0.05).The disappearance time of asthma symptom and mean hospitalization time in observation group were significantly lower than those in control group(P<0.01).Conclusions:Clinical nursing combined with home self-care for children with asthma can improve the effective rate of controlling asthma,reduce the recurrence rate of asthma,promote the improvement of asthma symptoms,and shorten the length of hospitalization time,which is worthy of promotion.
Objective:To explore the application value of clinical nursing combined with home self-care in children with asthma.Methods:Sixty children with asthma were randomly divided into the control group and observation group(30 cases each group).The control group was nursed with routine method,and the observation was nursed with clinical nursing combined with home self-care.The effective rate of controlling asthma,recurrence rate of asthma,disappearance time of asthma symptom,and mean hospitalization time of patients between two groups were compared.Results:The effective rate of controlling asthma in observation group(96.67%) was significantly higher than that in control group(63.33%)(P<0.01).The recurrence rate of asthma in observation group(6.67%) was lower than that in control group(26.67%)(P<0.05).The disappearance time of asthma symptom and mean hospitalization time in observation group were significantly lower than those in control group(P<0.01).Conclusions:Clinical nursing combined with home self-care for children with asthma can improve the effective rate of controlling asthma,reduce the recurrence rate of asthma,promote the improvement of asthma symptoms,and shorten the length of hospitalization time,which is worthy of promotion.
2017, 42(7): 1000-1002.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.051
Abstract:
Objective:To explore the effects of multimodal analgesia on alleviating the orthopedic preoperative pain.Methods:Seventy-six orthopedic preoperative patients were randomly divided into the observation group and control group.The observation group were treated with multimodal analgesia management,and the control group were treated with normal processing.The effect and degree of pain control,alleviating degree of pain and sleep satisfaction after 3 days of operation between two groups were compared.Results:The effects and satisfaction of pain control in observation group were better than those in control group(P<0.05 to P<0.01).The alleviating degrees of pain and sleep satisfaction after 3 days of operation in observation group were significantly better than those in control group(P<0.01).Conclusions:The multimodal analgesia management can effectively control the orthopedic preoperative pain,and improve comfort and satisfaction of patients during treatment.
Objective:To explore the effects of multimodal analgesia on alleviating the orthopedic preoperative pain.Methods:Seventy-six orthopedic preoperative patients were randomly divided into the observation group and control group.The observation group were treated with multimodal analgesia management,and the control group were treated with normal processing.The effect and degree of pain control,alleviating degree of pain and sleep satisfaction after 3 days of operation between two groups were compared.Results:The effects and satisfaction of pain control in observation group were better than those in control group(P<0.05 to P<0.01).The alleviating degrees of pain and sleep satisfaction after 3 days of operation in observation group were significantly better than those in control group(P<0.01).Conclusions:The multimodal analgesia management can effectively control the orthopedic preoperative pain,and improve comfort and satisfaction of patients during treatment.
2017, 42(7): 1003-1005.
doi: 10.13898/j.cnki.issn.1000-2200.2017.07.052
Abstract:
Objective:To investigate the effects of the “Hospital-Community-Family” continuous care on the motor function and activities of daily living in stroke patients with limb dysfunction.Methods:One hundred and eight stroke patients were randomly divided into the observation group and control group(54 cases each group).The control group were treated with the routine guidance,and the observation group were treated with “Hospital-Community-Family” continuous care intervention.The treatment effects in two groups were evaluated at discharge from hospital and after 2,6 and 12 months of discharge from hospital.Results:After 12 months continuous nursing intervention,the motor function Brandt (Brunnstrom) score and Barthel index in observation group were significantly better than those in control group at 6 and 12 months of treatment(P<0.01).Conclusions:The "Hospital-Community-Family" continuous care intervention program combined with "Hospital-Community-Home" is helpful for the improvement of motor function recovery and daily living activity in stroke patients,and the "Hospital-Community-Family" is conducive to improve the work capacity of community nurses.
Objective:To investigate the effects of the “Hospital-Community-Family” continuous care on the motor function and activities of daily living in stroke patients with limb dysfunction.Methods:One hundred and eight stroke patients were randomly divided into the observation group and control group(54 cases each group).The control group were treated with the routine guidance,and the observation group were treated with “Hospital-Community-Family” continuous care intervention.The treatment effects in two groups were evaluated at discharge from hospital and after 2,6 and 12 months of discharge from hospital.Results:After 12 months continuous nursing intervention,the motor function Brandt (Brunnstrom) score and Barthel index in observation group were significantly better than those in control group at 6 and 12 months of treatment(P<0.01).Conclusions:The "Hospital-Community-Family" continuous care intervention program combined with "Hospital-Community-Home" is helpful for the improvement of motor function recovery and daily living activity in stroke patients,and the "Hospital-Community-Family" is conducive to improve the work capacity of community nurses.
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