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2017 Vol. 42, No. 8
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2017, 42(8): 1013-1016.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.001
Abstract:
Objective:To study the effects of different orthodontic force values on the root resorption in rats with long-term drinking carbonated beverage.Methods:Twenty SD female rats(1 month old) were fed with 50 mL Coca-Cola each day.After 3 months,the rats were divided into the group A(0 g),group B(30 g),group C(50 g) and group D(80 g)according to the applying force value,and added orthodontic device in maxillary first molar.The BMD in rats at 0 d,21 d and 3 months of feeding Cola was measured.The maxillary first molar and near tissue were obtained after 21 days of operation,and detected using CBCT and stained using HE to observe the root absorption.The root resorption index was calculated by tissue section,and the number of osteoclasts was observed by TRAP staining.Results:With the increasing of feeding Cola time,the BMD in each group gradually decreased,the difference of which was statistically significant(P<0.05).At the same time-point,the difference of BMD between each group was not statistically significant(P>0.05).CBCT results showed that the root resorption in group D,group C and group B gradually decreased.The tooth root resorption index and number of osteoclasts in group D,group C and group B gradually decreased(P<0.01),the difference of those between group B and group A was not statistically significant(P>0.05).The bone remodeling in group B during orthodontic tooth movement is more active than that in group C and group D.Conclusions:The effect of 30 g force value on the root resorption in rats with long-term drinking carbonated beverage is the minimum,and the root resorption gradually increases with the increasing of force value.
Objective:To study the effects of different orthodontic force values on the root resorption in rats with long-term drinking carbonated beverage.Methods:Twenty SD female rats(1 month old) were fed with 50 mL Coca-Cola each day.After 3 months,the rats were divided into the group A(0 g),group B(30 g),group C(50 g) and group D(80 g)according to the applying force value,and added orthodontic device in maxillary first molar.The BMD in rats at 0 d,21 d and 3 months of feeding Cola was measured.The maxillary first molar and near tissue were obtained after 21 days of operation,and detected using CBCT and stained using HE to observe the root absorption.The root resorption index was calculated by tissue section,and the number of osteoclasts was observed by TRAP staining.Results:With the increasing of feeding Cola time,the BMD in each group gradually decreased,the difference of which was statistically significant(P<0.05).At the same time-point,the difference of BMD between each group was not statistically significant(P>0.05).CBCT results showed that the root resorption in group D,group C and group B gradually decreased.The tooth root resorption index and number of osteoclasts in group D,group C and group B gradually decreased(P<0.01),the difference of those between group B and group A was not statistically significant(P>0.05).The bone remodeling in group B during orthodontic tooth movement is more active than that in group C and group D.Conclusions:The effect of 30 g force value on the root resorption in rats with long-term drinking carbonated beverage is the minimum,and the root resorption gradually increases with the increasing of force value.
2017, 42(8): 1017-1021.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.002
Abstract:
Objective:To investigate the correlations between uridine-diphosphoglucuronate glucuronosyltransferase 1 family polypetide A1(UGT1A1) gene polymorphism,and the toxicity and efficacy of irinotecan in the treatment of advanced gastrointestinal cancer.Methods:The UGT1A1 genotypes in 62 advanced gastrointestinal cancer patients before treatment with irinotecan were detected using the polymerase chain reaction and high-resolution melting analysis.The correlations between UGT1A1 gene polymorphisms,and the toxicity and efficacy of irinotecan were analyzed.Results:The distribution frequency of wild-type(TA6/6),heterozygous mutant-type(TA6/7) and homozygous mutant-type(TA7/7) in UGT1A1*28 loci were 77.4%,11.3%,and 11.3%,respectively.The proportion of wild-type(G/G),heterozygous mutant-type(G/A) and homozygous mutant-type(A/A) in UGT1A1*6 loci were 79.1%,16.1% and 4.8%,respectively.Compared with the wild types of UGT1A1*28 and UGT1A1*6,the risks of the more than grade 3 diarrhea and neutropenia in mutant types of UGT1A1*28 and UGT1A1*6 increased(P<0.05 to P<0.01).The difference of the efficacy between different genotypes of UGT1A1 was not statistically significant(P>0.05).Conclusions:During the irinotecan in the treatment of advanced gastrointestinal cancer,the locus mutations of UGT1A1*28 and UGT1A1*6 can be regarded as the predictors of irinotecan-associated severe delayed diarrhea and neutropenia.The correlation between UGT1A1 gene polymorphism and efficacy of irinotecan is not found.
Objective:To investigate the correlations between uridine-diphosphoglucuronate glucuronosyltransferase 1 family polypetide A1(UGT1A1) gene polymorphism,and the toxicity and efficacy of irinotecan in the treatment of advanced gastrointestinal cancer.Methods:The UGT1A1 genotypes in 62 advanced gastrointestinal cancer patients before treatment with irinotecan were detected using the polymerase chain reaction and high-resolution melting analysis.The correlations between UGT1A1 gene polymorphisms,and the toxicity and efficacy of irinotecan were analyzed.Results:The distribution frequency of wild-type(TA6/6),heterozygous mutant-type(TA6/7) and homozygous mutant-type(TA7/7) in UGT1A1*28 loci were 77.4%,11.3%,and 11.3%,respectively.The proportion of wild-type(G/G),heterozygous mutant-type(G/A) and homozygous mutant-type(A/A) in UGT1A1*6 loci were 79.1%,16.1% and 4.8%,respectively.Compared with the wild types of UGT1A1*28 and UGT1A1*6,the risks of the more than grade 3 diarrhea and neutropenia in mutant types of UGT1A1*28 and UGT1A1*6 increased(P<0.05 to P<0.01).The difference of the efficacy between different genotypes of UGT1A1 was not statistically significant(P>0.05).Conclusions:During the irinotecan in the treatment of advanced gastrointestinal cancer,the locus mutations of UGT1A1*28 and UGT1A1*6 can be regarded as the predictors of irinotecan-associated severe delayed diarrhea and neutropenia.The correlation between UGT1A1 gene polymorphism and efficacy of irinotecan is not found.
2017, 42(8): 1022-1024,1028.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.003
Abstract:
Objective:To compare the pregnancy and birth outcome of single frozen-thawed blastocyst transfer in patients of different ages.Methods:The data of 2 414 cycles of single frozen-thawed blastocyst transfer were retrospectively analyzed.The clinical pregnancy rate,implantation rate,abortion rate,ectopic pregnancy rate,multiple pregnancy rate,premature delivery rate,low birth weight rate,birth defect rate and neonatal death rate between the fifth day and sixth day of single frozen-thawed blastocyst transfer(group D5 and group D6) were compared in patients less than 35 years old and patients more than or equal to 35 years old.Results:Regardless of age,the clinical pregnancy rate and implantation rate in group D5 were higher than those in group D6(P<0.01).The differences of the abortion rate,multiple pregnancy rate,premature delivery rate,low birth weight rate,birth defect rate and neonatal death rate between group D5 and D6 group were not statistically significant(P>0.05).Among the patients less than 35 years old,the ectopic pregnancy rate in group D5 was higher than that in group D6(P<0.01).Conclusions:Regardless of patients' age,the pregnancy outcome and birth outcome of the day 5 and day 6 single blastocyst transfer are good,and that of the day 5 is better than that of the day 6,and the days singk frozen-thawed blastocyst transfer should be the first choice.
Objective:To compare the pregnancy and birth outcome of single frozen-thawed blastocyst transfer in patients of different ages.Methods:The data of 2 414 cycles of single frozen-thawed blastocyst transfer were retrospectively analyzed.The clinical pregnancy rate,implantation rate,abortion rate,ectopic pregnancy rate,multiple pregnancy rate,premature delivery rate,low birth weight rate,birth defect rate and neonatal death rate between the fifth day and sixth day of single frozen-thawed blastocyst transfer(group D5 and group D6) were compared in patients less than 35 years old and patients more than or equal to 35 years old.Results:Regardless of age,the clinical pregnancy rate and implantation rate in group D5 were higher than those in group D6(P<0.01).The differences of the abortion rate,multiple pregnancy rate,premature delivery rate,low birth weight rate,birth defect rate and neonatal death rate between group D5 and D6 group were not statistically significant(P>0.05).Among the patients less than 35 years old,the ectopic pregnancy rate in group D5 was higher than that in group D6(P<0.01).Conclusions:Regardless of patients' age,the pregnancy outcome and birth outcome of the day 5 and day 6 single blastocyst transfer are good,and that of the day 5 is better than that of the day 6,and the days singk frozen-thawed blastocyst transfer should be the first choice.
2017, 42(8): 1025-1028.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.004
Abstract:
Objective:To evaluate the effects of repetitive transcranial magnetic stimulation(rTMS) combined with galantamine in the treatment of Alzheimer's disease(AD).Methods:Forty-three AD patients were randomly divided into the galantamine group(21 cases) and galantamine + rTMS group(22 cases).The scores of simple intelligent state scale(MMSE),clinical dementia scale(CDR),daily life ability scale(ADL) in two groups were evaluated before and after treatment.Results:The difference of the total effective rate between two groups after 6 months of treatment was not statistically significant(P>0.05).The differences of the scores of MMSE,ADL and CDR between two groups before treatment were not statistically significant(P>0.05).After 6 months of treatment,the MMSE scores increased(P<0.05),and the scores of ADL and CDR decreased in two groups(P<0.01).After 6 months of treatment,the MMSE score in galantamine group was lower than that in galantamine + rTMS group at the same point(P<0.01),and the scores of ADL and CDR in galantamine group were higher than those in galantamine+rTMS group(P<0.01).The differences of the incubation of N1,N2 and P3 between double sides high frequency and right side high frequency complicated with left side low frequency groups before treatment were not statistically significant(P>0.05).The wave amplitude of N1,N2 and P3 before and after treatment had no significant change in two groups(P>0.05),the incubation of P3 wave shorten after treatment(P<0.01).Compared with the right side high frequency complicated with left side low frequency group,the incubation of P3 in double sides high frequency group significantly shorten after treatment(P<0.01).Conclusions:The total effective rate of rTMS combined with galantamine in the treatment of AD is higher than that of galantamine.The scores of MMSE,ADL and RAD show that the clinical effect of rTMS combined with galantamine in the treatment of AD is better than that of galantamine.
Objective:To evaluate the effects of repetitive transcranial magnetic stimulation(rTMS) combined with galantamine in the treatment of Alzheimer's disease(AD).Methods:Forty-three AD patients were randomly divided into the galantamine group(21 cases) and galantamine + rTMS group(22 cases).The scores of simple intelligent state scale(MMSE),clinical dementia scale(CDR),daily life ability scale(ADL) in two groups were evaluated before and after treatment.Results:The difference of the total effective rate between two groups after 6 months of treatment was not statistically significant(P>0.05).The differences of the scores of MMSE,ADL and CDR between two groups before treatment were not statistically significant(P>0.05).After 6 months of treatment,the MMSE scores increased(P<0.05),and the scores of ADL and CDR decreased in two groups(P<0.01).After 6 months of treatment,the MMSE score in galantamine group was lower than that in galantamine + rTMS group at the same point(P<0.01),and the scores of ADL and CDR in galantamine group were higher than those in galantamine+rTMS group(P<0.01).The differences of the incubation of N1,N2 and P3 between double sides high frequency and right side high frequency complicated with left side low frequency groups before treatment were not statistically significant(P>0.05).The wave amplitude of N1,N2 and P3 before and after treatment had no significant change in two groups(P>0.05),the incubation of P3 wave shorten after treatment(P<0.01).Compared with the right side high frequency complicated with left side low frequency group,the incubation of P3 in double sides high frequency group significantly shorten after treatment(P<0.01).Conclusions:The total effective rate of rTMS combined with galantamine in the treatment of AD is higher than that of galantamine.The scores of MMSE,ADL and RAD show that the clinical effect of rTMS combined with galantamine in the treatment of AD is better than that of galantamine.
2017, 42(8): 1029-1031,1035.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.005
Abstract:
Objective:To observe the efficacy and safety of irinotecan combined with raltitrexed in the second-line chemotherapy of advanced colorectal cancer.Methods:Twenty-two patients with advanced colorectal cancer were treated with the second-line chemotherapy after the first-line treatment failure.The patients were treated with 180 mg/m2 of irinotecan by intravenous infusion for 1 h on the first day,and 3 mg/m2 of raltitrexed by intravenous infusion for 15 minutes on the second day,21 days as a cycle.The efficacy and safety were evaluated every 2 cycles.Results:The short-term efficacy of all cases was evaluated.The complete response in 1 case,partial response in 4 cases,stable disease in 11 cases and progressive disease in 6 cases were found.The objective response and disease control rates were 22.7% and 72.7%,respectively.The median time of tumor progression and median overall survival time were 5.0 and 11.8 months,respectively.The neutrophilopenia and diarrhea were serious adverse reactions,the incidence rates of those were 13.6% and 4.5%,respectively.Conclusions:The irinotecan combined with raltitrexed in the second-line chemotherapy of advanced colorectal cancer is high efficacy,and the adverse reactions can be tolerated,which is worthy of wider application.
Objective:To observe the efficacy and safety of irinotecan combined with raltitrexed in the second-line chemotherapy of advanced colorectal cancer.Methods:Twenty-two patients with advanced colorectal cancer were treated with the second-line chemotherapy after the first-line treatment failure.The patients were treated with 180 mg/m2 of irinotecan by intravenous infusion for 1 h on the first day,and 3 mg/m2 of raltitrexed by intravenous infusion for 15 minutes on the second day,21 days as a cycle.The efficacy and safety were evaluated every 2 cycles.Results:The short-term efficacy of all cases was evaluated.The complete response in 1 case,partial response in 4 cases,stable disease in 11 cases and progressive disease in 6 cases were found.The objective response and disease control rates were 22.7% and 72.7%,respectively.The median time of tumor progression and median overall survival time were 5.0 and 11.8 months,respectively.The neutrophilopenia and diarrhea were serious adverse reactions,the incidence rates of those were 13.6% and 4.5%,respectively.Conclusions:The irinotecan combined with raltitrexed in the second-line chemotherapy of advanced colorectal cancer is high efficacy,and the adverse reactions can be tolerated,which is worthy of wider application.
2017, 42(8): 1032-1035.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.006
Abstract:
Objective:To investigate the effects of minocycline injection via the root canal combined with modern root canal therapy on the periodontal index and bacterial infection in patients with pulp-periodontal syndrome.Methods:One hundred and twenty-eight patients with pulp-periodontal syndrome were randomly divided into the observation group and control group(64 cases each group).The control group was treated with periodontal pocket injection of minocycline hydrochloride combined with modern root canal therapy,and the observation group was treated with minocycline injection via root canal combined with modern root canal therapy.The curative effect,periodontal index,bacterial infection and adverse reaction between two groups were compared.Results:The total effective rate in observation group(95.3%) was significantly better than that in control group(78.1%)(P<0.01).The differences of the plaque index(PLI),bleeding index(BI) after probing,periodontal pocket depth(PD) and gingival index(GI) before treatment between two groups were not statistically significant(P>0.05).At the end of treatment,the levels of the PLI,PD,BI and GI in two groups significantly decreased,and the decreasing degrees of PLI,PD,BI and GI in observation group were more than those in control group(P<0.05 to P<0.01).After 3 months of treatment,the decreasing degrees of PD and GI in observation group were lower and higher than those in control group,respectively(P<0.05).The difference of the bacterial infection rate between two groups before treatment was not statistically significant(P>0.05),and the bacterial infection rate in observation group after treatment was significantly lower than that in control group(P<0.01).The difference of the drug resistance rate between two groups within treatment was not statistically significant(P>0.05).The difference of the incidence rate of adverse reaction between two groups was not statistically significant(P>0.05).Conclusions:The minocycline injection via root canal combined with modern root canal therapy treating pulp-periodontal syndrome can improve the periodontal index and clinical effect,decrease the bacterial infection rate of patients,which is worthy of popularizing.
Objective:To investigate the effects of minocycline injection via the root canal combined with modern root canal therapy on the periodontal index and bacterial infection in patients with pulp-periodontal syndrome.Methods:One hundred and twenty-eight patients with pulp-periodontal syndrome were randomly divided into the observation group and control group(64 cases each group).The control group was treated with periodontal pocket injection of minocycline hydrochloride combined with modern root canal therapy,and the observation group was treated with minocycline injection via root canal combined with modern root canal therapy.The curative effect,periodontal index,bacterial infection and adverse reaction between two groups were compared.Results:The total effective rate in observation group(95.3%) was significantly better than that in control group(78.1%)(P<0.01).The differences of the plaque index(PLI),bleeding index(BI) after probing,periodontal pocket depth(PD) and gingival index(GI) before treatment between two groups were not statistically significant(P>0.05).At the end of treatment,the levels of the PLI,PD,BI and GI in two groups significantly decreased,and the decreasing degrees of PLI,PD,BI and GI in observation group were more than those in control group(P<0.05 to P<0.01).After 3 months of treatment,the decreasing degrees of PD and GI in observation group were lower and higher than those in control group,respectively(P<0.05).The difference of the bacterial infection rate between two groups before treatment was not statistically significant(P>0.05),and the bacterial infection rate in observation group after treatment was significantly lower than that in control group(P<0.01).The difference of the drug resistance rate between two groups within treatment was not statistically significant(P>0.05).The difference of the incidence rate of adverse reaction between two groups was not statistically significant(P>0.05).Conclusions:The minocycline injection via root canal combined with modern root canal therapy treating pulp-periodontal syndrome can improve the periodontal index and clinical effect,decrease the bacterial infection rate of patients,which is worthy of popularizing.
2017, 42(8): 1036-1038.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.007
Abstract:
Objective:To discuss the effects of the changes of insulin-like growth factor-1 (IGF-1) levels on the quality of life and nutritional status in elderly male patients.Methods:A total of 50 elderly male patients(60-95 years old) were divided into 2 groups according to age:the elderly patient group(60-79 years old,n=20) and the older patient group(over 80 years old,n=30).Levels of IGF-1 were detected.The SF-36 questionnaire,micro-nutrient assessment table (MNA-SF),and geriatric nutritional risk index(GNRI) were conducted to evaluate the quality of life and nutritional status.Results:The IGF-1 level was higher in the older patient group[(112.1±46.4) μg/L] than that in the elderly patient group[(82.8±42.1) μg/L](P<0.05).In addition to body pain score,scores of other 7 dimensions of SF-36 scale in the older patient group were significantly lower than those in the elderly patient group(P<0.01).Scores of MNA-SF and GNRI in the older patient group were also significantly lower than those in the elderly patient group(P<0.01).Correlation analysis showed that age had a negative correlation with IGF-1 level in elderly male patients(P<0.05).After adjusting the age,IGF-1 level was positively correlated with physical function,role of physical activity,body pain,general health,vitality,mental health,emotional function and nutritional status in SF-36 scale(P<0.01),and had no obvious correlation with social function(P>0.05).IGF-1 level was also positively correlated with scores of MNA-SF and GNRI(P<0.01 and P<0.05).Conclusions:The level of serum IGF-1 in elderly male patients was low,and was negatively correlated with age,which can seriously affect the quality of life and nutritional status in elderly patients.
Objective:To discuss the effects of the changes of insulin-like growth factor-1 (IGF-1) levels on the quality of life and nutritional status in elderly male patients.Methods:A total of 50 elderly male patients(60-95 years old) were divided into 2 groups according to age:the elderly patient group(60-79 years old,n=20) and the older patient group(over 80 years old,n=30).Levels of IGF-1 were detected.The SF-36 questionnaire,micro-nutrient assessment table (MNA-SF),and geriatric nutritional risk index(GNRI) were conducted to evaluate the quality of life and nutritional status.Results:The IGF-1 level was higher in the older patient group[(112.1±46.4) μg/L] than that in the elderly patient group[(82.8±42.1) μg/L](P<0.05).In addition to body pain score,scores of other 7 dimensions of SF-36 scale in the older patient group were significantly lower than those in the elderly patient group(P<0.01).Scores of MNA-SF and GNRI in the older patient group were also significantly lower than those in the elderly patient group(P<0.01).Correlation analysis showed that age had a negative correlation with IGF-1 level in elderly male patients(P<0.05).After adjusting the age,IGF-1 level was positively correlated with physical function,role of physical activity,body pain,general health,vitality,mental health,emotional function and nutritional status in SF-36 scale(P<0.01),and had no obvious correlation with social function(P>0.05).IGF-1 level was also positively correlated with scores of MNA-SF and GNRI(P<0.01 and P<0.05).Conclusions:The level of serum IGF-1 in elderly male patients was low,and was negatively correlated with age,which can seriously affect the quality of life and nutritional status in elderly patients.
2017, 42(8): 1039-1041.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.008
Abstract:
Objective:To evaluate the effects of pharmacist intervention on preventive use antibiotics in perioperation of clean incision.Methods:All patients with clean incision operation in December2015(pre-intervention group) and April2016(post-intervention group) were selected.The indicators of preventive use of antibiotics between before and after intervention of clinical pharmacist were compared.Results:After clinical pharmacist intervention,the administration time and drug variety of preventive use antibiotics in perioperation of clean incision changed(P<0.01),the course of drug use was significantly shortened(P<0.01),and the drug expense significantly decreased compared before intervention(P<0.01).Conclusions:The pharmacist intervention on preventive use antibiotics in perioperation of clean incision has a certain significance in promoting the rational use of antibacterial drug and decreasing the expense of antibacterial drug。
Objective:To evaluate the effects of pharmacist intervention on preventive use antibiotics in perioperation of clean incision.Methods:All patients with clean incision operation in December2015(pre-intervention group) and April2016(post-intervention group) were selected.The indicators of preventive use of antibiotics between before and after intervention of clinical pharmacist were compared.Results:After clinical pharmacist intervention,the administration time and drug variety of preventive use antibiotics in perioperation of clean incision changed(P<0.01),the course of drug use was significantly shortened(P<0.01),and the drug expense significantly decreased compared before intervention(P<0.01).Conclusions:The pharmacist intervention on preventive use antibiotics in perioperation of clean incision has a certain significance in promoting the rational use of antibacterial drug and decreasing the expense of antibacterial drug。
2017, 42(8): 1042-1044,1047.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.009
Abstract:
Objective:To explore the correlations between the levels of lipoprotein(a)[Lp(a)] and cystatin-C(Cys-C),and severity of coronary artery disease(CHD).Methods:The patients suspected with CHD were divided into the group A(0 point,n=100),group B(1 to 30 points,n=152),group C(31 to 90 points,n=48) and group D(≥ 91 points,n=39) according to the severity of CHD(using Gensini scoring of coronarography).The levels of fasting plasma glucose(FPG),triglycerides(TG),cholesterol(TC),high-density lipoprotein cholesterol(HDL),low-density lipoprotein cholesterol(LDL),serum creatinine(SCr),blood urea nitrogen(BUN),4(a),Cys-C and homocysteine in all patients were detected,the correlations between the levels of Lp(a) and Cys-C,and Gensini scoring of coronarography in four groups were analyzed.Results:The differences of the levels of TG,LDL,BUN and SCr between four groups were not statistically significant(P>0.05).Compared with group A and B,the levels of FPG,TC and Cys-C in group D significantly increased(P<0.05 to P<0.01).Compared with group A,the level of Hcy in group C and D was increased(P<0.05).With the increasing of severity of CHD,the level of Lp(a) significantly increased(P<0.01).The levels of Cys-C and Lp(a) were positively correlated with the Gensini score(P<0.01).Conclusions:The levels of serum Lp(a) and Cys-C are closely related to the severity of CHD.
Objective:To explore the correlations between the levels of lipoprotein(a)[Lp(a)] and cystatin-C(Cys-C),and severity of coronary artery disease(CHD).Methods:The patients suspected with CHD were divided into the group A(0 point,n=100),group B(1 to 30 points,n=152),group C(31 to 90 points,n=48) and group D(≥ 91 points,n=39) according to the severity of CHD(using Gensini scoring of coronarography).The levels of fasting plasma glucose(FPG),triglycerides(TG),cholesterol(TC),high-density lipoprotein cholesterol(HDL),low-density lipoprotein cholesterol(LDL),serum creatinine(SCr),blood urea nitrogen(BUN),4(a),Cys-C and homocysteine in all patients were detected,the correlations between the levels of Lp(a) and Cys-C,and Gensini scoring of coronarography in four groups were analyzed.Results:The differences of the levels of TG,LDL,BUN and SCr between four groups were not statistically significant(P>0.05).Compared with group A and B,the levels of FPG,TC and Cys-C in group D significantly increased(P<0.05 to P<0.01).Compared with group A,the level of Hcy in group C and D was increased(P<0.05).With the increasing of severity of CHD,the level of Lp(a) significantly increased(P<0.01).The levels of Cys-C and Lp(a) were positively correlated with the Gensini score(P<0.01).Conclusions:The levels of serum Lp(a) and Cys-C are closely related to the severity of CHD.
2017, 42(8): 1045-1047.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.010
Abstract:
Objective:To explore the clinical effects of intravenous immunoglobulin(IVIG) in treating sever hand-foot-mouth disease(HFMD),and its influence on the serum levels of S-100β protein and neuron-specific enolase(NSE).Methods:Eighty-two patients with severe HFMD were randomly divided into the observation group and control group(41 cases each group),respectively.The control group and observation group were treated with conventional therapy and IVIG combined with conventional therapy,respectively.The clinical symptoms,neurological manifestations and hospitalization time in two groups were observed,and the serum levels of S-100β protein and NSE in two groups were detected.Results:The total effective rate in observation group(97.56%) was higher than that in control group(75.61%)(P<0.05).The rash disappearing time,temperature recovery time,disappearance time of easy fright and limb tremor and hospitalization time in observation group were shorter than those in control group(P<0.05 to P<0.01).The serum levels of S-100β protein and NSE in observation group significantly decreased after treatment(P<0.01).Conclusions:The treatment of severe HFMD with IVIG combined with conventional therapy can shorten the duration of clinical signs and symptoms,decrease hospitalization time and the serum levels of S-100β and NSE,and improve the clinical effects.
Objective:To explore the clinical effects of intravenous immunoglobulin(IVIG) in treating sever hand-foot-mouth disease(HFMD),and its influence on the serum levels of S-100β protein and neuron-specific enolase(NSE).Methods:Eighty-two patients with severe HFMD were randomly divided into the observation group and control group(41 cases each group),respectively.The control group and observation group were treated with conventional therapy and IVIG combined with conventional therapy,respectively.The clinical symptoms,neurological manifestations and hospitalization time in two groups were observed,and the serum levels of S-100β protein and NSE in two groups were detected.Results:The total effective rate in observation group(97.56%) was higher than that in control group(75.61%)(P<0.05).The rash disappearing time,temperature recovery time,disappearance time of easy fright and limb tremor and hospitalization time in observation group were shorter than those in control group(P<0.05 to P<0.01).The serum levels of S-100β protein and NSE in observation group significantly decreased after treatment(P<0.01).Conclusions:The treatment of severe HFMD with IVIG combined with conventional therapy can shorten the duration of clinical signs and symptoms,decrease hospitalization time and the serum levels of S-100β and NSE,and improve the clinical effects.
2017, 42(8): 1048-1050.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.011
Abstract:
Objective:To explore the value of the plasma levels of BNP,CRP and D-dimer in evaluating the aged patients with atrial fibrillation(AF) complicated with chronic heart failure(CHF).Methods:The clinical data of 46 aged patients with AF complicated with CHF(AF group) and 46 aged patients with CHF complicated with sinus rhythm(sinus rhythm group)from December 2014 to December 2016 were retrospective analyzed.The patients were divided into gradeⅡ,Ⅲ and Ⅳ groups according to the NYHA heart function classification.The differences and correlations of BNP,CRP,D-dimer and LVEF between two groups were compared.Results:At the same heart function classification,the levels of plasma BNP,CRP and D-dimer in AF group were significantly higher than those in sinus rhythm group(P<0.01),and the levels of plasma BNP,CRP and D-dimer in two groups increased with the increasing of heart function classification(P<0.01).The LVEF in AF group was significantly lower than that in sinus rhythm group(P< 0.01).The levels of BNP and CRP were positively correlated with the cardiac function classification in aged patients with CHF complicated with AF.Conclusions:The levels of BNP,CRP and D-dimer in aged patients with CHF complicated with AF increase,which is significantly higher than those in sinus rhythm patients,and correlated with the severity of the disease.The combined detection has important significances in diagnosing the disease severity and prognosis of patients.
Objective:To explore the value of the plasma levels of BNP,CRP and D-dimer in evaluating the aged patients with atrial fibrillation(AF) complicated with chronic heart failure(CHF).Methods:The clinical data of 46 aged patients with AF complicated with CHF(AF group) and 46 aged patients with CHF complicated with sinus rhythm(sinus rhythm group)from December 2014 to December 2016 were retrospective analyzed.The patients were divided into gradeⅡ,Ⅲ and Ⅳ groups according to the NYHA heart function classification.The differences and correlations of BNP,CRP,D-dimer and LVEF between two groups were compared.Results:At the same heart function classification,the levels of plasma BNP,CRP and D-dimer in AF group were significantly higher than those in sinus rhythm group(P<0.01),and the levels of plasma BNP,CRP and D-dimer in two groups increased with the increasing of heart function classification(P<0.01).The LVEF in AF group was significantly lower than that in sinus rhythm group(P< 0.01).The levels of BNP and CRP were positively correlated with the cardiac function classification in aged patients with CHF complicated with AF.Conclusions:The levels of BNP,CRP and D-dimer in aged patients with CHF complicated with AF increase,which is significantly higher than those in sinus rhythm patients,and correlated with the severity of the disease.The combined detection has important significances in diagnosing the disease severity and prognosis of patients.
2017, 42(8): 1051-1053.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.012
Abstract:
Objective:To investigate the clinical value of the intraoperative molecular diagnosis of sentinel lymph node in breast cancer,and provide the accurate and convenient intraoperative diagnosis method for breast cancer.Methods:The sentinel lymph node biopsies in 73 patients during operation were examined.The molecular diagnosis,quick frozen pathological detection and printing slice cytology test in intraoperative sentinel lymph node tissue of breast cancer were detected.The pathology of the layered sentinel lymph node tissue block after surgery was finished,and the result of which was set as the diagnostic gold standard.Results:The diagnostic sensitivities of molecular diagnosis,quick frozen pathological detection and printing slice cytology in sentinel lymph nodes of breast cancer were 84.62%,73.08% and 69.23%,respectively,and the sensitivity of molecular diagnosis in sentinel lymph node of breast cancer was significantly higher than that of quick frozen pathological detection and printing slice cytology test(P<0.05).Among the 70 times of molecular diagnosis test in sentinel lymph node of breast cancer,the average operation time of the first 10 times,11 to 25 times and 26 to 70 times was(53.28±3.93)min,(42.19±3.44)min and (31.73±2.57)min,respectively.With the increasing of operating frequency and shortening of operation time,the good learning curve was found(P<0.01).The cycle thresholds of mammaglobin and cytokeratin 19 were significantly negatively correlated with the metastases size(P<0.05).Conclusions:The diagnostic sensitivity of molecular diagnosis in sentinel lymph node of breast cancer is higher than that of quick frozen pathological detection and printing slice cytology test.The molecular diagnostic method is easy to grasp,and has high clinical values.
Objective:To investigate the clinical value of the intraoperative molecular diagnosis of sentinel lymph node in breast cancer,and provide the accurate and convenient intraoperative diagnosis method for breast cancer.Methods:The sentinel lymph node biopsies in 73 patients during operation were examined.The molecular diagnosis,quick frozen pathological detection and printing slice cytology test in intraoperative sentinel lymph node tissue of breast cancer were detected.The pathology of the layered sentinel lymph node tissue block after surgery was finished,and the result of which was set as the diagnostic gold standard.Results:The diagnostic sensitivities of molecular diagnosis,quick frozen pathological detection and printing slice cytology in sentinel lymph nodes of breast cancer were 84.62%,73.08% and 69.23%,respectively,and the sensitivity of molecular diagnosis in sentinel lymph node of breast cancer was significantly higher than that of quick frozen pathological detection and printing slice cytology test(P<0.05).Among the 70 times of molecular diagnosis test in sentinel lymph node of breast cancer,the average operation time of the first 10 times,11 to 25 times and 26 to 70 times was(53.28±3.93)min,(42.19±3.44)min and (31.73±2.57)min,respectively.With the increasing of operating frequency and shortening of operation time,the good learning curve was found(P<0.01).The cycle thresholds of mammaglobin and cytokeratin 19 were significantly negatively correlated with the metastases size(P<0.05).Conclusions:The diagnostic sensitivity of molecular diagnosis in sentinel lymph node of breast cancer is higher than that of quick frozen pathological detection and printing slice cytology test.The molecular diagnostic method is easy to grasp,and has high clinical values.
2017, 42(8): 1054-1058.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.013
Abstract:
Objective:To investigate the accurate clinical substaging of Barcelona Clinic Liver Cancer(BCLC) stage B and C.Methods:A total of 854 intermediate and advanced hepatocellular carcinoma(HCC)patients including 429 cases of BCLC stage B and 425 cases of BCLC stage C were studied.Overall survival and related risk factor in all cases were analyzed,and all patients were substaged.Results:BCLC stage B could be subdivided into the stage B1(tumor size ≤ 5 cm and Child-Pugh A or B),B2(tumor size >5 cm and Child-Pugh A) and B3(tumor size >5cm and Child-Pugh B).BCLC stage C could be subdivided into the stage C1(no portal vein invasion and extra-hepatic metastasis),C2(portal vein invasion or extra-hepatic metastasis) and C3(portal vein invasion and extra-hepatic metastasis).At BCLC stage B patients with tumor diameter ≤ 5 cm,the Child-Pugh staging of liver function did not affect the prognosis.The difference of 1-year survival rate between stage B3 and C1 patients was not statistically significant(P>0.05).Conclusions:The accuracy of BCLC staging in predicting the prognosis of patients with intermediate and advanced HCC is not enough,and the substaging might be useful for determining the prognosis of patient and guiding treatment strategies.
Objective:To investigate the accurate clinical substaging of Barcelona Clinic Liver Cancer(BCLC) stage B and C.Methods:A total of 854 intermediate and advanced hepatocellular carcinoma(HCC)patients including 429 cases of BCLC stage B and 425 cases of BCLC stage C were studied.Overall survival and related risk factor in all cases were analyzed,and all patients were substaged.Results:BCLC stage B could be subdivided into the stage B1(tumor size ≤ 5 cm and Child-Pugh A or B),B2(tumor size >5 cm and Child-Pugh A) and B3(tumor size >5cm and Child-Pugh B).BCLC stage C could be subdivided into the stage C1(no portal vein invasion and extra-hepatic metastasis),C2(portal vein invasion or extra-hepatic metastasis) and C3(portal vein invasion and extra-hepatic metastasis).At BCLC stage B patients with tumor diameter ≤ 5 cm,the Child-Pugh staging of liver function did not affect the prognosis.The difference of 1-year survival rate between stage B3 and C1 patients was not statistically significant(P>0.05).Conclusions:The accuracy of BCLC staging in predicting the prognosis of patients with intermediate and advanced HCC is not enough,and the substaging might be useful for determining the prognosis of patient and guiding treatment strategies.
2017, 42(8): 1058-1060.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.014
Abstract:
Objective:To compare the clinical effects of continuous pumping ebrantil with nitroprusside in the treatment of hypertension complicated with acute left heart failure.Methods:One hundred and twelve patients with acute left heart failure complicated with hypertension were divided into the observation group and control group according to the random number method(56 cases each group).The observation group and control group were treated with ebrantil and nitroprusside by continuous intravenous pumping based on comprehensive treatment,respectively.The clinical effects and adverse reactions in two groups were observed.Results:After 24 h of treatment,the total effective rate in observation group(92.9%) was significantly higher than that in control group(71.4%)(P<0.05).After 1 h of treatment,the heart rate,systolic blood pressure and diastolic blood pressure in two groups were significantly improved(P<0.05),the difference of systolic blood pressure in observation group was significantly improved compared with control group(P<0.05),and the differences of changes of the heart rate and diastolic blood pressure between two groups were not statistically significant(P>0.05).The difference of the level of NT-proBNP between two groups before treatment was not statistically significant(P>0.05).The levels of NT-proBNP in two groups after treatment decreased compared with before treatment,but the decreasing degree of which was more obvious in observation group(P<0.05).The incidence rate of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusions:Compared with nitroprusside,the treatment of hypertension complicated with acute left heart failure with ebrantil has lower adverse reactions and good effects,which is worthy of clinical promotion.
Objective:To compare the clinical effects of continuous pumping ebrantil with nitroprusside in the treatment of hypertension complicated with acute left heart failure.Methods:One hundred and twelve patients with acute left heart failure complicated with hypertension were divided into the observation group and control group according to the random number method(56 cases each group).The observation group and control group were treated with ebrantil and nitroprusside by continuous intravenous pumping based on comprehensive treatment,respectively.The clinical effects and adverse reactions in two groups were observed.Results:After 24 h of treatment,the total effective rate in observation group(92.9%) was significantly higher than that in control group(71.4%)(P<0.05).After 1 h of treatment,the heart rate,systolic blood pressure and diastolic blood pressure in two groups were significantly improved(P<0.05),the difference of systolic blood pressure in observation group was significantly improved compared with control group(P<0.05),and the differences of changes of the heart rate and diastolic blood pressure between two groups were not statistically significant(P>0.05).The difference of the level of NT-proBNP between two groups before treatment was not statistically significant(P>0.05).The levels of NT-proBNP in two groups after treatment decreased compared with before treatment,but the decreasing degree of which was more obvious in observation group(P<0.05).The incidence rate of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusions:Compared with nitroprusside,the treatment of hypertension complicated with acute left heart failure with ebrantil has lower adverse reactions and good effects,which is worthy of clinical promotion.
2017, 42(8): 1061-1063,1066.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.015
Abstract:
Objective:To investigate the effects of different time of clamping umbilical cord on premature infant with vaginal delivery.Methods:One hundred and twenty premature infants with vaginal delivery and puerperas were investigated.One hundred and twenty puerperas were randomly divided into group A,B,C and D according to the random number table method(30 cases each group).The umbilical cord in group A,B,C and D were clamped after 0,30,60 and 90 seconds of delivery,respectively.The basic data of newborns and puerperas were collected,and the hemoglobin(Hb) level of newborn,red blood cells deposited(HCT) value,incidence of anemia,blood transfusion rate,transcutaneous bilirubin peak value,phototherapy time,incidence of high bilirubin hematic disease and incidence of intracerebral haemorrhage were recorded in all groups.Results:The 24 h Hb level and HCT value in group B,C and D were higher than those in group A(P<0.05),and the differences of those between group B,C and D were not statistically significant(P>0.05).The Hb level and HCT value in newborns of group B,C and D after 1 week of birth were higher than those in group A(P<0.01),which in group D was higher than that in group B and C(P< 0.01),and the difference of which between group B and group C was not statistically significant(P>0.05).The incidence rates of anemia and blood transfusion in premature infants of group B,C and D were lower than those in group A(P<0.05),and the differences of which between group B,group C and group D were not statistically significant(P>0.05).The differences of the transcutaneous bilirubin peak value,phototherapy time,incidence of high bilirubin hematic disease and incidence of intracerebral haemorrhage between four groups were not statistically significant(P>0.05).Conclusions:The clamping umbilical cord of premature infant with vaginal delivery after 30 to 90 seconds of delivery can improve the neonatal blood supply,reduce the incidence of anemia and blood transfusion rate,and do not increase the risk of bilirubin increasing and phototherapy.The clamping umbilical cord of premature infants after 90 seconds of delivery can effectively improve their prognosis.
Objective:To investigate the effects of different time of clamping umbilical cord on premature infant with vaginal delivery.Methods:One hundred and twenty premature infants with vaginal delivery and puerperas were investigated.One hundred and twenty puerperas were randomly divided into group A,B,C and D according to the random number table method(30 cases each group).The umbilical cord in group A,B,C and D were clamped after 0,30,60 and 90 seconds of delivery,respectively.The basic data of newborns and puerperas were collected,and the hemoglobin(Hb) level of newborn,red blood cells deposited(HCT) value,incidence of anemia,blood transfusion rate,transcutaneous bilirubin peak value,phototherapy time,incidence of high bilirubin hematic disease and incidence of intracerebral haemorrhage were recorded in all groups.Results:The 24 h Hb level and HCT value in group B,C and D were higher than those in group A(P<0.05),and the differences of those between group B,C and D were not statistically significant(P>0.05).The Hb level and HCT value in newborns of group B,C and D after 1 week of birth were higher than those in group A(P<0.01),which in group D was higher than that in group B and C(P< 0.01),and the difference of which between group B and group C was not statistically significant(P>0.05).The incidence rates of anemia and blood transfusion in premature infants of group B,C and D were lower than those in group A(P<0.05),and the differences of which between group B,group C and group D were not statistically significant(P>0.05).The differences of the transcutaneous bilirubin peak value,phototherapy time,incidence of high bilirubin hematic disease and incidence of intracerebral haemorrhage between four groups were not statistically significant(P>0.05).Conclusions:The clamping umbilical cord of premature infant with vaginal delivery after 30 to 90 seconds of delivery can improve the neonatal blood supply,reduce the incidence of anemia and blood transfusion rate,and do not increase the risk of bilirubin increasing and phototherapy.The clamping umbilical cord of premature infants after 90 seconds of delivery can effectively improve their prognosis.
2017, 42(8): 1064-1066.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.016
Abstract:
Objective:To observe the effects of the intervening homocysteine(Hcy) on cognitive function in patients with cerebral infarction.Methods:Seventy-two cerebral infarction patients with high Hcy complicated with cognition impairment were randomly divided into the control group and observation group(36 cases each group).The control group was treated with the routine method,and the observation group was treated with 500 mg mexobalamin by oral,three times a day,based on routine treatment.Before treatment and 4 weeks,3 and 6 months after treatment,the levels of Hcy in two groups were detected,and the cognitive function in two groups was evaluated using Mini-mental state examination(MMSE) and Barthel index(BI).Results:The difference of the level of Hcy in control group between before and after treatment was not statistically significant(P>0.05).Compared with the control group,the level of Hcy in observation group after treatment significantly decreased(P<0.01),and which was significantly lower than that in control group at the same time(P<0.01).The differences of the MMSE and BI scores before treatment between two groups were not statistically significant(P>0.05).The difference of the MMSE score in control group between before and after treatment was not statistically significant(P>0.05),and the BI scores in control group 3 and 6 months after treatment were significantly better than those of before treatment(P<0.01).Compared with before treatment,the scores of MMSE and BI in observation group 3 and 6 months after treatment significantly increased,and were significantly lower than those in control group(P<0.01).Conclusions:The decreasement of the Hcy level can improve the cognitive function in patients with cerebral infarction.
Objective:To observe the effects of the intervening homocysteine(Hcy) on cognitive function in patients with cerebral infarction.Methods:Seventy-two cerebral infarction patients with high Hcy complicated with cognition impairment were randomly divided into the control group and observation group(36 cases each group).The control group was treated with the routine method,and the observation group was treated with 500 mg mexobalamin by oral,three times a day,based on routine treatment.Before treatment and 4 weeks,3 and 6 months after treatment,the levels of Hcy in two groups were detected,and the cognitive function in two groups was evaluated using Mini-mental state examination(MMSE) and Barthel index(BI).Results:The difference of the level of Hcy in control group between before and after treatment was not statistically significant(P>0.05).Compared with the control group,the level of Hcy in observation group after treatment significantly decreased(P<0.01),and which was significantly lower than that in control group at the same time(P<0.01).The differences of the MMSE and BI scores before treatment between two groups were not statistically significant(P>0.05).The difference of the MMSE score in control group between before and after treatment was not statistically significant(P>0.05),and the BI scores in control group 3 and 6 months after treatment were significantly better than those of before treatment(P<0.01).Compared with before treatment,the scores of MMSE and BI in observation group 3 and 6 months after treatment significantly increased,and were significantly lower than those in control group(P<0.01).Conclusions:The decreasement of the Hcy level can improve the cognitive function in patients with cerebral infarction.
2017, 42(8): 1067-1070.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.017
Abstract:
Objective:To investigate the effects of obesity on the frequency and severity of migraine attack in children.Methods:Eighty-three children with migraine were divided into the normal weight group,overweight group and obesity group according to the body mass index.The characteristics and accompanying symptoms(omen,awesome sound,photophobia,nausea and vomiting) of migraine between three groups were compared.The correlation between obesity,and the duration,frequency of attack and severity of migraine were investigated.Results:The prevalence of obesity in children with migraine was 15.7%.The migraine attack in obesity group was more than that in normal weight group(P<0.05).The differences of the headache severity and duration between three groups were not statistically significant(P>0.05).Relative body mass index was positively correlated with the number of attacks(P<0.05).Obesity did not significantly affect the accompanying symptoms of migraine.Conclusions:Obesity is related to the frequency of migraine attack in children,and the early prevention and treatment should be emphasized.
Objective:To investigate the effects of obesity on the frequency and severity of migraine attack in children.Methods:Eighty-three children with migraine were divided into the normal weight group,overweight group and obesity group according to the body mass index.The characteristics and accompanying symptoms(omen,awesome sound,photophobia,nausea and vomiting) of migraine between three groups were compared.The correlation between obesity,and the duration,frequency of attack and severity of migraine were investigated.Results:The prevalence of obesity in children with migraine was 15.7%.The migraine attack in obesity group was more than that in normal weight group(P<0.05).The differences of the headache severity and duration between three groups were not statistically significant(P>0.05).Relative body mass index was positively correlated with the number of attacks(P<0.05).Obesity did not significantly affect the accompanying symptoms of migraine.Conclusions:Obesity is related to the frequency of migraine attack in children,and the early prevention and treatment should be emphasized.
2017, 42(8): 1070-1072.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.018
Abstract:
Objective:To study the effects of zoledronic acid on blood lipid and bone mineral density(BMD),and the relationship between blood lipid and BMD.Methods:One hundred and three postmenopausal osteoporosis patients were randomly divided into the treatment group(53 cases) and control group(50 cases).The treatment group was treated with 5 mg of zoledronic acid by intravenous infusionin one time 1 year,600 mg of caltrate D daily and 0.25 μg of alfacalcidol D3 daily for 12 months.The control group was treated with 600 mg of caltrate D daily and 0.25 μg of alfacalcidol D3 daily for 12 months.The levels of the bone density and blood lipid before and after treatment between two groups were compared.Results:After 12 months of treatment,the total bone density of L2-4,ward triangle and proximal femur in treatment group were higher than those in control group(P<0.05),and the levels of cholesterol and in treatment group were lower than those in control group(P<0.05).The differences of the levels of triacylglycerol and between two groups were not statistically significant after treatment(P>0.05).Conclusions:After the treatment of postmenopausal osteoporosis with 5mg of zoledronic acid,the BMD of lumbar vertebrae and proximal femur of osteoporosis patients obviously increases,and the blood lipid markedly decreases.
Objective:To study the effects of zoledronic acid on blood lipid and bone mineral density(BMD),and the relationship between blood lipid and BMD.Methods:One hundred and three postmenopausal osteoporosis patients were randomly divided into the treatment group(53 cases) and control group(50 cases).The treatment group was treated with 5 mg of zoledronic acid by intravenous infusionin one time 1 year,600 mg of caltrate D daily and 0.25 μg of alfacalcidol D3 daily for 12 months.The control group was treated with 600 mg of caltrate D daily and 0.25 μg of alfacalcidol D3 daily for 12 months.The levels of the bone density and blood lipid before and after treatment between two groups were compared.Results:After 12 months of treatment,the total bone density of L2-4,ward triangle and proximal femur in treatment group were higher than those in control group(P<0.05),and the levels of cholesterol and in treatment group were lower than those in control group(P<0.05).The differences of the levels of triacylglycerol and between two groups were not statistically significant after treatment(P>0.05).Conclusions:After the treatment of postmenopausal osteoporosis with 5mg of zoledronic acid,the BMD of lumbar vertebrae and proximal femur of osteoporosis patients obviously increases,and the blood lipid markedly decreases.
2017, 42(8): 1073-1075,1079.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.019
Abstract:
Objective:To summarize the clinical characteristics and diagnosis of neurosyphilis.Methods:The clinical data of 3 patients with neurosyphilis were retrospectively analyzed.The literatures about neurosyphilis from in CNKI,VIP and Wanfang database were searched,and these literatures were published in Chinese Sci-tech Core Periodicals from 1994 to 2014.Results:One hundred and thirty-three literatures(1 208 patients) were identified,1 028 patients(without 3 patients in this article) included 971 male cases(80.38%) and 237 female cases(19.62%) and the ratio of male to female was 4:1.The patients age was from 15 to 80 years old,and the patients over 60 years old was 126 cases(10.43%).The patients with play history(including spouse) in 634 cases(52.48%),HIV infection in 16 cases(1.32%),and misdiagnosis in 635 cases(52.57%) were found.The asymptomatic type neurosyphilis in 80 cases(6.62%),meningeal(spinal) type neurosyphilis in 149 cases(12.33%),meningovascular(spinal) type neurosyphilis in 389 cases(32.20%),paralytic dementia in 457 cases(37.83%),tabesdorsalis in 94 cases(7.78%),syphilitic gumma in 16 cases(1.32%),mixed type in 22 cases(1.82%) and special type(common peroneal nerve neurosyphilis) in 1 case(0.08%) were identified.Conclusions:Neurosyphilis is often found in young and middle-aged men with various clinical manifestations and high misdiagnosis rate,which can mainly be diagnosed by serum and cerebrospinal fluid examination.The imaging and electrophysiological examinations are not specific.
Objective:To summarize the clinical characteristics and diagnosis of neurosyphilis.Methods:The clinical data of 3 patients with neurosyphilis were retrospectively analyzed.The literatures about neurosyphilis from in CNKI,VIP and Wanfang database were searched,and these literatures were published in Chinese Sci-tech Core Periodicals from 1994 to 2014.Results:One hundred and thirty-three literatures(1 208 patients) were identified,1 028 patients(without 3 patients in this article) included 971 male cases(80.38%) and 237 female cases(19.62%) and the ratio of male to female was 4:1.The patients age was from 15 to 80 years old,and the patients over 60 years old was 126 cases(10.43%).The patients with play history(including spouse) in 634 cases(52.48%),HIV infection in 16 cases(1.32%),and misdiagnosis in 635 cases(52.57%) were found.The asymptomatic type neurosyphilis in 80 cases(6.62%),meningeal(spinal) type neurosyphilis in 149 cases(12.33%),meningovascular(spinal) type neurosyphilis in 389 cases(32.20%),paralytic dementia in 457 cases(37.83%),tabesdorsalis in 94 cases(7.78%),syphilitic gumma in 16 cases(1.32%),mixed type in 22 cases(1.82%) and special type(common peroneal nerve neurosyphilis) in 1 case(0.08%) were identified.Conclusions:Neurosyphilis is often found in young and middle-aged men with various clinical manifestations and high misdiagnosis rate,which can mainly be diagnosed by serum and cerebrospinal fluid examination.The imaging and electrophysiological examinations are not specific.
2017, 42(8): 1076-1079.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.020
Abstract:
Objective:To explore the clinical effects of the nerve growth factor(NGF) in the treatment of intracerebral hemorrhage,and effects of NGF on the nerve dysfunction,Barthel index(BI) score and osteopontin(OPN) expression.Methods:Eighty-four patients with intracerebral hemorrhage were randomly divided into the control group and observation group using random number method(42 cases each group).The control group was treated with conventional method combined with citicoline,and the observation group was additionally treated with NGF based on conventional method for 2 weeks.The National Institutes of Health Stroke Scale(NIHSS) and BI scores,OPN expression level and clinical efficiency between two groups were analyzed and compared after treatment.Results:The differences of the NIHSS and BI scores,and OPN expression level before treatment between two groups were not statistically significant(P>0.05).After treatment,the NIHSS score and OPN expression level in two groups significantly decreased,and the decreasing degree of those in observation group was significantly higher than that in control group(P<0.01).After treatment,the BI scores in two groups significantly increased,and the increasing degree of which in observation group was significantly higher than that in control group(P<0.01).The total effective rate of treatment in observation group(90.5%) was higher than that in control group(71.4%)(P<0.05).The curative effect in observation group was better than that in control group(P<0.05).Conclusions:The effect of NGF in the treatment of intracerebral hemorrhage is significant and safe,which can effectively improve the clinical symptoms and nerve dysfunction,reduce the OPN level,promote the recovery of patients,and is worthy of promotion.
Objective:To explore the clinical effects of the nerve growth factor(NGF) in the treatment of intracerebral hemorrhage,and effects of NGF on the nerve dysfunction,Barthel index(BI) score and osteopontin(OPN) expression.Methods:Eighty-four patients with intracerebral hemorrhage were randomly divided into the control group and observation group using random number method(42 cases each group).The control group was treated with conventional method combined with citicoline,and the observation group was additionally treated with NGF based on conventional method for 2 weeks.The National Institutes of Health Stroke Scale(NIHSS) and BI scores,OPN expression level and clinical efficiency between two groups were analyzed and compared after treatment.Results:The differences of the NIHSS and BI scores,and OPN expression level before treatment between two groups were not statistically significant(P>0.05).After treatment,the NIHSS score and OPN expression level in two groups significantly decreased,and the decreasing degree of those in observation group was significantly higher than that in control group(P<0.01).After treatment,the BI scores in two groups significantly increased,and the increasing degree of which in observation group was significantly higher than that in control group(P<0.01).The total effective rate of treatment in observation group(90.5%) was higher than that in control group(71.4%)(P<0.05).The curative effect in observation group was better than that in control group(P<0.05).Conclusions:The effect of NGF in the treatment of intracerebral hemorrhage is significant and safe,which can effectively improve the clinical symptoms and nerve dysfunction,reduce the OPN level,promote the recovery of patients,and is worthy of promotion.
2017, 42(8): 1080-1082,1086.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.021
Abstract:
Objective:To investigate the clinical effects and features of Medpor in the repairment of orbital blowout fracture(BOF) and compound fracture.Methods:The position and size of orbital fractures in 23 patients were identified using the high resolution CT scan and 3-D reconstruction.The degree of enophthalmos was measured using Hertel exophthalmometer,the diplopia was analyzed using synoptophore,and Medpor was used as the major orbital grafting material.The patients were followed up for 6 to 12 months.Results:Within the following up for more than 6 months,21 cases(95%) were completely corrected among 22 cases with enophthalmos more than 2 mm,12 cases(85%) were completely corrected among 14 cases with diplopia,and 10 cases(90%) recovered normal among 11 cases with movement limitation of eyeball before operation.The differences of the degrees of enophthalmos,movement limitation and deplopia between the postoperative 2 weeks,3 months and 6 months were statistically significant(P<0.05).Conclusions:As a new plastic surgery material,Medpor can be used to repair the orbital fracture,and effectively correct the moderate to severe enophthalmos and diplopia.
Objective:To investigate the clinical effects and features of Medpor in the repairment of orbital blowout fracture(BOF) and compound fracture.Methods:The position and size of orbital fractures in 23 patients were identified using the high resolution CT scan and 3-D reconstruction.The degree of enophthalmos was measured using Hertel exophthalmometer,the diplopia was analyzed using synoptophore,and Medpor was used as the major orbital grafting material.The patients were followed up for 6 to 12 months.Results:Within the following up for more than 6 months,21 cases(95%) were completely corrected among 22 cases with enophthalmos more than 2 mm,12 cases(85%) were completely corrected among 14 cases with diplopia,and 10 cases(90%) recovered normal among 11 cases with movement limitation of eyeball before operation.The differences of the degrees of enophthalmos,movement limitation and deplopia between the postoperative 2 weeks,3 months and 6 months were statistically significant(P<0.05).Conclusions:As a new plastic surgery material,Medpor can be used to repair the orbital fracture,and effectively correct the moderate to severe enophthalmos and diplopia.
2017, 42(8): 1083-1086.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.022
Abstract:
Objective:To investigate the clinical manifestations,laboratory examination and clinical features of liver damage in different age children with infectious mononucleosis(IM).Methods:Sixty IM children were divided into the age less than 6-year-old group and age more than or equal to 6-year-old group according to the average age of children(30 cases each group).The main symptoms and signs,laboratory test results and incidence rate of complications between two groups were compared using the unified clinical and laboratory indicators.The relationships between alanine aminotransferase(ALT)level and fever duration and children age in two groups were analyzed.Results:The varying degrees of symptoms and signs in two groups were found.The duration of feve and highest temperature in two groups were 3 to 31 d and 37.5 to 40.1℃,respectively,and the differences of those were not statistically significant(P>0.05).Among 60 cases,fever in 54 cases(90.00%),lymphadenopathy in 47 cases(78.33%),rash in 10 cases(16.67%) and angina in 40 cases(66.67%) were identified.The incidence rates of splenomegaly and hepatomegaly in age <6-year-old children group were higher,and the differences of those between two groups were statistically significant(P<0.05).The differences of the proportions of white blood cells,atypical lymphocytes and lymphocytes between two groups were not statistically significant(P>0.05).The levels of ALT and aspartate aminotransferase in age < 6-year-old children group were lower than those in age more than or equal to 6-year-old group(P<0.05).The varying degrees of complications(including liver damage,pneumonia,myocardial damage,anemia,thrombocytopenia and neutropenia) in two groups were found.Forty-seven cases with liver function demage(78.33%) in two groups were found,and the difference of which between two groups was statistically significant(P<0.05),the differences of other complications between two groups were not statistically significant(P>0.05).The ALT level was correlated with the duration of fever,and the longer the fever time and higher the abnormal rate,the degree of liver damage was the greater.The difference of the abnormal level of ALT in different age children was not statistically different(P>0.05).Conclusions:The clinical manifestations,laboratory tests and complication in differnent age IM children exist differences,and the liver dysfunction is the most common complication.Hepatosplenomegaly is common in preschool children,and liver dysfunction is common in older children.
Objective:To investigate the clinical manifestations,laboratory examination and clinical features of liver damage in different age children with infectious mononucleosis(IM).Methods:Sixty IM children were divided into the age less than 6-year-old group and age more than or equal to 6-year-old group according to the average age of children(30 cases each group).The main symptoms and signs,laboratory test results and incidence rate of complications between two groups were compared using the unified clinical and laboratory indicators.The relationships between alanine aminotransferase(ALT)level and fever duration and children age in two groups were analyzed.Results:The varying degrees of symptoms and signs in two groups were found.The duration of feve and highest temperature in two groups were 3 to 31 d and 37.5 to 40.1℃,respectively,and the differences of those were not statistically significant(P>0.05).Among 60 cases,fever in 54 cases(90.00%),lymphadenopathy in 47 cases(78.33%),rash in 10 cases(16.67%) and angina in 40 cases(66.67%) were identified.The incidence rates of splenomegaly and hepatomegaly in age <6-year-old children group were higher,and the differences of those between two groups were statistically significant(P<0.05).The differences of the proportions of white blood cells,atypical lymphocytes and lymphocytes between two groups were not statistically significant(P>0.05).The levels of ALT and aspartate aminotransferase in age < 6-year-old children group were lower than those in age more than or equal to 6-year-old group(P<0.05).The varying degrees of complications(including liver damage,pneumonia,myocardial damage,anemia,thrombocytopenia and neutropenia) in two groups were found.Forty-seven cases with liver function demage(78.33%) in two groups were found,and the difference of which between two groups was statistically significant(P<0.05),the differences of other complications between two groups were not statistically significant(P>0.05).The ALT level was correlated with the duration of fever,and the longer the fever time and higher the abnormal rate,the degree of liver damage was the greater.The difference of the abnormal level of ALT in different age children was not statistically different(P>0.05).Conclusions:The clinical manifestations,laboratory tests and complication in differnent age IM children exist differences,and the liver dysfunction is the most common complication.Hepatosplenomegaly is common in preschool children,and liver dysfunction is common in older children.
2017, 42(8): 1087-1091.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.023
Abstract:
Objective:To explore the related factors of the cervical lymph node metastasis in papillary thyroid microcarcinoma,and provide a theoretical basis in deciding the range of neck lymph node dissection.Methods:The clinical data of the papillary thyroid microcarcinoma patients treated with operation were collected,and the pathological and clinical characteristics were retrospectively analyzed.The correlations between age,gender,tumor size,number of lesions,capsular invasion and hashimoto's thyroiditis,HIF-1α and VEGF,and cervical lymph node metastasis were analyzed using logistic regression.Results:Among 325 patients,the cervical lymph node metastasis in 112 cases(34.5%),central area lymph node metastasis in 109 cases(33.5%) and lateral lymph node metastasis in 104 cases(32.0%) were found.The male,age less than 45 years old,tumor size more than 0.5 cm,capsular invasion and hashimoto's thyroiditis,positive HIF-1α and VEGF were the risk factors of the cervical lymph node metastasis in papillary thyroid microcarcinoma(P< 0.05).Conclusions:The lymph node metastasis rate of papillary thyroid microcarcinoma is high.The independent risk factors can provide an important basis in the correct treatment of the disease.
Objective:To explore the related factors of the cervical lymph node metastasis in papillary thyroid microcarcinoma,and provide a theoretical basis in deciding the range of neck lymph node dissection.Methods:The clinical data of the papillary thyroid microcarcinoma patients treated with operation were collected,and the pathological and clinical characteristics were retrospectively analyzed.The correlations between age,gender,tumor size,number of lesions,capsular invasion and hashimoto's thyroiditis,HIF-1α and VEGF,and cervical lymph node metastasis were analyzed using logistic regression.Results:Among 325 patients,the cervical lymph node metastasis in 112 cases(34.5%),central area lymph node metastasis in 109 cases(33.5%) and lateral lymph node metastasis in 104 cases(32.0%) were found.The male,age less than 45 years old,tumor size more than 0.5 cm,capsular invasion and hashimoto's thyroiditis,positive HIF-1α and VEGF were the risk factors of the cervical lymph node metastasis in papillary thyroid microcarcinoma(P< 0.05).Conclusions:The lymph node metastasis rate of papillary thyroid microcarcinoma is high.The independent risk factors can provide an important basis in the correct treatment of the disease.
2017, 42(8): 1091-1093.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.024
Abstract:
Objective:To explore the application value of the nutrition support after damage control surgery in patients with colorectal cancer complicated with intestinal obstruction.Methods:The level of the serum albumin(ALB),prealbumin,blood Na+ and HCO3-,body mass and body mass index in 43 patients with colorectal cancer complicated with intestinal obstruction were analyzed.ALL were treated with early enteral nutrition or Parenteral nutrition support and damage control surgical concept.These complications and prognosis of patients were observed.Results:Compared with the patients after 1 day of operation,the levels of the serum ALB,and blood Na+ and HCO3- of patients 7 days after operation significantly increased(P<0.01),and the level of prealbumin,abdominal circumference,body mass and body mass index of patients 7 days after operation significantly decreased(P<0.01).Conclusions:The treatment of the colorectal cancer complicated with intestinal obstruction with the early nutrition support combined with damage control surgery can improve the postoperative nutrition condition and prognosis,and enhance the cure rate of patients.
Objective:To explore the application value of the nutrition support after damage control surgery in patients with colorectal cancer complicated with intestinal obstruction.Methods:The level of the serum albumin(ALB),prealbumin,blood Na+ and HCO3-,body mass and body mass index in 43 patients with colorectal cancer complicated with intestinal obstruction were analyzed.ALL were treated with early enteral nutrition or Parenteral nutrition support and damage control surgical concept.These complications and prognosis of patients were observed.Results:Compared with the patients after 1 day of operation,the levels of the serum ALB,and blood Na+ and HCO3- of patients 7 days after operation significantly increased(P<0.01),and the level of prealbumin,abdominal circumference,body mass and body mass index of patients 7 days after operation significantly decreased(P<0.01).Conclusions:The treatment of the colorectal cancer complicated with intestinal obstruction with the early nutrition support combined with damage control surgery can improve the postoperative nutrition condition and prognosis,and enhance the cure rate of patients.
2017, 42(8): 1094-1097.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.025
Abstract:
Objective:To explore the influencing factors of the surgical tolerance and postoperative hip function in elderly patients with hip fractures.Methods:A total of 119 patients with femur intertrochanteric fractures were divided into the operation group and non-operation group according to the surgical tolerance of patients.The function of hip joint in operation group after operation was evaluated using hip joint Harris scare.The single factor and multiple factors regression analysis were carried out using the postoperative function of hip joint as dependent variable,and the influencing factor of postoperative function of hip joint as independent variable.Results:The score of surgical tolerance in the operation group[(78.6±12.2) points] was significantly better than that in non-operation group[(61.8±10.1)points](P<0.01).The results of single factor analysis showed that the function scores of hip joint in patients with advanced age,long fracture time,non-stable fracture,low quality reduction,postoperatively poor recovery,postoperative complications,hip replacement,preoperative complication,and preoperative high grade ASA were lower(P<0.01).The results of multiple factors regression analysis showed that the advanced age,long fracture time,non-stable fracture,low quality reduction,postoperatively poor recovery,postoperative complications were the independent risk factor of hip joint function after operation(P<0.05 to P<0.01).Conclusions:The surgical tolerance in elderly patients with hip fractures should be evaluated before operation,and the related risk factors of affecting the hip joint function should timely be intervened.
Objective:To explore the influencing factors of the surgical tolerance and postoperative hip function in elderly patients with hip fractures.Methods:A total of 119 patients with femur intertrochanteric fractures were divided into the operation group and non-operation group according to the surgical tolerance of patients.The function of hip joint in operation group after operation was evaluated using hip joint Harris scare.The single factor and multiple factors regression analysis were carried out using the postoperative function of hip joint as dependent variable,and the influencing factor of postoperative function of hip joint as independent variable.Results:The score of surgical tolerance in the operation group[(78.6±12.2) points] was significantly better than that in non-operation group[(61.8±10.1)points](P<0.01).The results of single factor analysis showed that the function scores of hip joint in patients with advanced age,long fracture time,non-stable fracture,low quality reduction,postoperatively poor recovery,postoperative complications,hip replacement,preoperative complication,and preoperative high grade ASA were lower(P<0.01).The results of multiple factors regression analysis showed that the advanced age,long fracture time,non-stable fracture,low quality reduction,postoperatively poor recovery,postoperative complications were the independent risk factor of hip joint function after operation(P<0.05 to P<0.01).Conclusions:The surgical tolerance in elderly patients with hip fractures should be evaluated before operation,and the related risk factors of affecting the hip joint function should timely be intervened.
2017, 42(8): 1097-1099.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.026
Abstract:
Objective:To study the correlation between the serum level of cystatin C(Cys-C)and coronary heart disease(CHD),and its clinical significance.Methods:The suspected CHD patients were detected using selective coronary angiography,and 164 CHD patients and 99 non-CHD patients were divided into the CHD group and control group,respectively.The serum levels of Cys-C in all cases were tested.The correlations between the coronary artery lesion,Gensini score and Cys-C level were analyzed using Pearson correlation analysis.Results:Compared with the control group,the levels of Cys-C in CHD group significantly increased(P<0.05).Among CHD group,the levels of Cys-C in unstable angina pectoris group were higher than that in stable angina group(P<0.05),but the levels of Cys-C in acute myocardial infarction group were lower than that in stable angina group(P<0.05).The area under the ROC curve of CHD diagnosed by Cys-C was 0.711(P<0.05).Taken 1.105 mg/L as the Cut-off value,the sensitivity and specificity of CHD diagnosed by Cys-C were 73.2% and 55.6%,respectively.The level of Cys-C was positively related with the Gensini score(r=0.332,P<0.05) and the number of coronary artery lesion(r=0.413,P<0.05).Conclusions:Cys-C could be used as a noninvasive predictor of CHD,which is closely related to the degree of coronary artery lesion.
Objective:To study the correlation between the serum level of cystatin C(Cys-C)and coronary heart disease(CHD),and its clinical significance.Methods:The suspected CHD patients were detected using selective coronary angiography,and 164 CHD patients and 99 non-CHD patients were divided into the CHD group and control group,respectively.The serum levels of Cys-C in all cases were tested.The correlations between the coronary artery lesion,Gensini score and Cys-C level were analyzed using Pearson correlation analysis.Results:Compared with the control group,the levels of Cys-C in CHD group significantly increased(P<0.05).Among CHD group,the levels of Cys-C in unstable angina pectoris group were higher than that in stable angina group(P<0.05),but the levels of Cys-C in acute myocardial infarction group were lower than that in stable angina group(P<0.05).The area under the ROC curve of CHD diagnosed by Cys-C was 0.711(P<0.05).Taken 1.105 mg/L as the Cut-off value,the sensitivity and specificity of CHD diagnosed by Cys-C were 73.2% and 55.6%,respectively.The level of Cys-C was positively related with the Gensini score(r=0.332,P<0.05) and the number of coronary artery lesion(r=0.413,P<0.05).Conclusions:Cys-C could be used as a noninvasive predictor of CHD,which is closely related to the degree of coronary artery lesion.
2017, 42(8): 1100-1102.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.027
Abstract:
Objective:To explore the curative effects and safety of azithromycin combined with budesonide suspension liquid and salbutamol atomization inhalation in the treatment of pediatric mycoplasma pneumoniae pneumonia.Methods:Sixty-five children with mycoplasma pneumoniae pneumonia were randomly divided into the control group and observation group.The control group was treated with azithromycin,and the observation group treated with azithromycin combined with budesonide suspension liquid and salbutamol atomization inhalation.The lung function before and after treatment,clinical effect after 1 course of treatment and adverse reactions between two groups were compared.Results:Compared with before treatment,the maximal expiratory flow(MEF) 25 to 75,MEF25 and MEF50 in observation group significantly increased after treatment(P<0.01).The total effective rate in observation group(96.97%) was higher than that in control group(81.25%)(P<0.05).The incidence rates of erythra,gastrointestinal tract reaction,alanine transaminase elevation and local pain reaction in observation group during treatment were lower than those in control group(P<0.05 to P<0.01).Conclusions:Azithromycin combined with budesonide suspension liquid and salbutamol atomization inhalation in the treatment of pediatric mycoplasma pneumoniae pneumonia can significantly improve the airway function and clinical effects,and reduce adverse reactions.
Objective:To explore the curative effects and safety of azithromycin combined with budesonide suspension liquid and salbutamol atomization inhalation in the treatment of pediatric mycoplasma pneumoniae pneumonia.Methods:Sixty-five children with mycoplasma pneumoniae pneumonia were randomly divided into the control group and observation group.The control group was treated with azithromycin,and the observation group treated with azithromycin combined with budesonide suspension liquid and salbutamol atomization inhalation.The lung function before and after treatment,clinical effect after 1 course of treatment and adverse reactions between two groups were compared.Results:Compared with before treatment,the maximal expiratory flow(MEF) 25 to 75,MEF25 and MEF50 in observation group significantly increased after treatment(P<0.01).The total effective rate in observation group(96.97%) was higher than that in control group(81.25%)(P<0.05).The incidence rates of erythra,gastrointestinal tract reaction,alanine transaminase elevation and local pain reaction in observation group during treatment were lower than those in control group(P<0.05 to P<0.01).Conclusions:Azithromycin combined with budesonide suspension liquid and salbutamol atomization inhalation in the treatment of pediatric mycoplasma pneumoniae pneumonia can significantly improve the airway function and clinical effects,and reduce adverse reactions.
2017, 42(8): 1103-1105.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.028
Abstract:
Objective:To investigate the effects of self-made ultrasonic examining bed in the screening of development dislocation of hip(DDH).Methods:Three hundred and twenty hip joints in 160 infants born more than 42 days were detected by ultrasound.The cases were examined using common examining bed combined with fixing the infant hip and lower limbs by hand by three doctors,and the cases were examined using infant hip joint ultrasonic examining bed again.The examining date between two methods were compared.Results:The deviation of α angle and β angle in left and right sides detected by infant hip joint examining bed were significantly less than those detected by the common bed(P<0.01).The difference of right side total result detected by FHC was significantly less than that of common bed(P<0.01).The intraclass correlation coefficient(ICC) of examination result using common bed by three doctors was less than 0.4,the consistency of which was poor.The intraclass correlation coefficient of examination result using infant hip joint examining bed was more than 0.75,the consistency of which was good.Conclusions:Ultrasonic examining bed for infant hip joint can significantly eliminate the anthropic factor influencing,and reduce the degree variation of date.
Objective:To investigate the effects of self-made ultrasonic examining bed in the screening of development dislocation of hip(DDH).Methods:Three hundred and twenty hip joints in 160 infants born more than 42 days were detected by ultrasound.The cases were examined using common examining bed combined with fixing the infant hip and lower limbs by hand by three doctors,and the cases were examined using infant hip joint ultrasonic examining bed again.The examining date between two methods were compared.Results:The deviation of α angle and β angle in left and right sides detected by infant hip joint examining bed were significantly less than those detected by the common bed(P<0.01).The difference of right side total result detected by FHC was significantly less than that of common bed(P<0.01).The intraclass correlation coefficient(ICC) of examination result using common bed by three doctors was less than 0.4,the consistency of which was poor.The intraclass correlation coefficient of examination result using infant hip joint examining bed was more than 0.75,the consistency of which was good.Conclusions:Ultrasonic examining bed for infant hip joint can significantly eliminate the anthropic factor influencing,and reduce the degree variation of date.
2017, 42(8): 1106-1108,1113.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.029
Abstract:
Objective:To investigate the effects of the gadoxetate disodium on signal-to-noise ratio(CNR),T2 relaxation time and apparent diffusion coefficient(ADC).Methods:The CNR and T2 relaxation times and ADC value in the liver parenchyma,liver cancer and hemangioma between before and after injection of gadoxetate disodium were compared.Results:The difference of the CNR in the venous phase between liver cancer and hemangioma was not statistically significant(P>0.05),while the differences of the CNR in plain phase,arterial phase,equilibrium phase and hepatobiliary phase between liver cancer and hemangioma were statistically significant(P<0.05).The CNR in venous phase,arterial phase,equilibrium phase and hepatobiliary phase were significantly higher than that in plain phase(P<0.01),and the CNR in hepatobiliary phase was significantly higher than that in venous phase,arterial phase and equilibrium phase(P<0.01).The difference of the T2 relaxation times and ADC value were not statistically significant(P>0.05).Conclusions:The scanning image acquisition of T2WI DWI and TSE sequence after the injection of contrast agent and scan does not affect the characteristics of the lesion,and can save the scan time,which can help to promote the wider application of gadoxetate disodium in clinic.
Objective:To investigate the effects of the gadoxetate disodium on signal-to-noise ratio(CNR),T2 relaxation time and apparent diffusion coefficient(ADC).Methods:The CNR and T2 relaxation times and ADC value in the liver parenchyma,liver cancer and hemangioma between before and after injection of gadoxetate disodium were compared.Results:The difference of the CNR in the venous phase between liver cancer and hemangioma was not statistically significant(P>0.05),while the differences of the CNR in plain phase,arterial phase,equilibrium phase and hepatobiliary phase between liver cancer and hemangioma were statistically significant(P<0.05).The CNR in venous phase,arterial phase,equilibrium phase and hepatobiliary phase were significantly higher than that in plain phase(P<0.01),and the CNR in hepatobiliary phase was significantly higher than that in venous phase,arterial phase and equilibrium phase(P<0.01).The difference of the T2 relaxation times and ADC value were not statistically significant(P>0.05).Conclusions:The scanning image acquisition of T2WI DWI and TSE sequence after the injection of contrast agent and scan does not affect the characteristics of the lesion,and can save the scan time,which can help to promote the wider application of gadoxetate disodium in clinic.
2017, 42(8): 1109-1113.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.030
Abstract:
Objective:To explore the characteristics of adversity quotient(AQ) and self-concept of college freshmen with rural left-behind experience,and its correlation.Methods:Two hundred and eighty-seven college students with rural left-behind experience and 133 rural college students without left-behind experience were investigated using the Adversity Quotient Inventory(AQI) and Tennessee Self-Concept Scale(TSCS).Results:Among the college students with rural left-behind experience,the endurance score in girl was higher than that in boy(P<0.05).The differences of the score of each factor and total score of AQ scale in college students with different rural left-behind time were not statistically significant(P>0.05).Compared with college students with left-behind from 6 to 11 years old,the total scores of AQI of college students with left-behind less than 6 years old,and more than 11 years old were lower(P<0.01 and P<0.05),the control factor score of college students with left-behind less than 6 years old was lower(P<0.05),and the elongation factor score of college students with left-behind more than 11 years old was lower(P<0.01).The scores of the physical self and self-concept in college students with left-behind experience were lower than those in college students without left-behind experience(P<0.05).The scores of self-moral,self-family and self-action in girl students with left-behind experience were higher than those in boy students(P<0.05 to P<0.01),and the score of self-criticism factor in girl students with left-behind experience was lower than that in boy students(P<0.01).The total score of AQI was correlated with the each factor score of TSCS,and the self-moral and self-social had positive predicting effect on the total score of AQI.Conclusions:Compared with the college students without left-behind experience,the development level of AQ in college students with left-behind experience is not obviously different,and the development level of self-concept is low.
Objective:To explore the characteristics of adversity quotient(AQ) and self-concept of college freshmen with rural left-behind experience,and its correlation.Methods:Two hundred and eighty-seven college students with rural left-behind experience and 133 rural college students without left-behind experience were investigated using the Adversity Quotient Inventory(AQI) and Tennessee Self-Concept Scale(TSCS).Results:Among the college students with rural left-behind experience,the endurance score in girl was higher than that in boy(P<0.05).The differences of the score of each factor and total score of AQ scale in college students with different rural left-behind time were not statistically significant(P>0.05).Compared with college students with left-behind from 6 to 11 years old,the total scores of AQI of college students with left-behind less than 6 years old,and more than 11 years old were lower(P<0.01 and P<0.05),the control factor score of college students with left-behind less than 6 years old was lower(P<0.05),and the elongation factor score of college students with left-behind more than 11 years old was lower(P<0.01).The scores of the physical self and self-concept in college students with left-behind experience were lower than those in college students without left-behind experience(P<0.05).The scores of self-moral,self-family and self-action in girl students with left-behind experience were higher than those in boy students(P<0.05 to P<0.01),and the score of self-criticism factor in girl students with left-behind experience was lower than that in boy students(P<0.01).The total score of AQI was correlated with the each factor score of TSCS,and the self-moral and self-social had positive predicting effect on the total score of AQI.Conclusions:Compared with the college students without left-behind experience,the development level of AQ in college students with left-behind experience is not obviously different,and the development level of self-concept is low.
2017, 42(8): 1114-1117.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.031
Abstract:
Objective:To investigate the significance of the serum cystatin C(CysC),microdose albumin(mAlb) and β2-microglobulin(β2-MG) detection in the diagnosis and prognosis of the acute kidney injury(AKI).Methods:Ninety-seven AKI patients were divided into the stage AKI 1(45 cases),stage AKI 2(27 cases) and stage AKI 3(25 cases),and 55 healthy people were set as the control group.The levels of CysC,mAlb and β2-MG were detected in each group,and the scores of acute physiology and chronic health evaluation Ⅱ (APACHEⅡ) in all cases were evaluated.Results:The differences of the serum levels of CysC,mAlb and urine β2-MG between fours groups were statistically significant(P<0.01),the levels of CysC,mAlb and urine β2-MG in AKI groups were significantly higher than those in control group(P<0.01),the levels of CysC,mAlb and urine β2-MG in AKI 2 and AKI 3 groups were significantly higher than those in AKI 1 group(P<0.01),and the levels of CysC,mAlb and urine β2-MG in AKI 3 groups were significantly higher than those in AKI 2 group(P<0.01).The differences of the scores of APACHEⅡ between four groups were statistically significant(P<0.01),the scores of APACHEⅡ in AKI 2 and AKI 3 groups were significantly higher than those in AKI 1 group(P<0.01),and the score of APACHEⅡ in AKI 3 group was significantly higher than that in AKI 2 group(P<0.01).The levels of serum CysC,mAlb and urine β2-MG were significantly positive correlated with APACHEⅡ score(P<0.01).The positive rate of the combined detection of serum CysC,mAlb and β2-MG in the diagnosis of AKI was significantly higher than that of the independent 3 indicator(P<0.05).The levels of serum CysC,mAlb,urine β2-MG and APACHEⅡ score in survival cases were significantly lower than those in death cases(P<0.01).Conclusions:The serum CysC,mAlb and urine β2-MG are closely related to the severity and prognosis of AKI patients,which can be used as an important indicator in evaluating the severity and prognosis of AKI patients.
Objective:To investigate the significance of the serum cystatin C(CysC),microdose albumin(mAlb) and β2-microglobulin(β2-MG) detection in the diagnosis and prognosis of the acute kidney injury(AKI).Methods:Ninety-seven AKI patients were divided into the stage AKI 1(45 cases),stage AKI 2(27 cases) and stage AKI 3(25 cases),and 55 healthy people were set as the control group.The levels of CysC,mAlb and β2-MG were detected in each group,and the scores of acute physiology and chronic health evaluation Ⅱ (APACHEⅡ) in all cases were evaluated.Results:The differences of the serum levels of CysC,mAlb and urine β2-MG between fours groups were statistically significant(P<0.01),the levels of CysC,mAlb and urine β2-MG in AKI groups were significantly higher than those in control group(P<0.01),the levels of CysC,mAlb and urine β2-MG in AKI 2 and AKI 3 groups were significantly higher than those in AKI 1 group(P<0.01),and the levels of CysC,mAlb and urine β2-MG in AKI 3 groups were significantly higher than those in AKI 2 group(P<0.01).The differences of the scores of APACHEⅡ between four groups were statistically significant(P<0.01),the scores of APACHEⅡ in AKI 2 and AKI 3 groups were significantly higher than those in AKI 1 group(P<0.01),and the score of APACHEⅡ in AKI 3 group was significantly higher than that in AKI 2 group(P<0.01).The levels of serum CysC,mAlb and urine β2-MG were significantly positive correlated with APACHEⅡ score(P<0.01).The positive rate of the combined detection of serum CysC,mAlb and β2-MG in the diagnosis of AKI was significantly higher than that of the independent 3 indicator(P<0.05).The levels of serum CysC,mAlb,urine β2-MG and APACHEⅡ score in survival cases were significantly lower than those in death cases(P<0.01).Conclusions:The serum CysC,mAlb and urine β2-MG are closely related to the severity and prognosis of AKI patients,which can be used as an important indicator in evaluating the severity and prognosis of AKI patients.
2017, 42(8): 1122-1124.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.034
Abstract:
Objective:To explore the effects of the family responsibility interactive nursing mode on the function recovery of multiple fractures of metatarsal,and nursing satisfaction degree.Methods:Sixty patients with multiple fractures of metatarsal in 2015(30 cases) and 2014(30 cases) were divided into the control group and observation group,respectively.The control group and observation group were nursed with the routine nursing mode and family responsibility interactive nursing mode,respectively.The foot function recovery,hospitalization time,health knowledge and incidence of complications between two groups were compared.All patients were followed up.Results:No complication in two groups was found.The hospitalization time in observation group was less than that in control group(P < 0.01),the excellent and good rate of foot function recovery in observation group was better than that in control group(P<0.01),and the mastering healthy knowledge in observation group was better than that in control group(P<0.01).Conclusions:The application of the family responsibility interactive nursing mode in the multiple fractures of metatarsal can promote the wound healing,and quickly recover the foot function.This nursing mode has higher satisfaction in patients,which is worthy of promotion in clinic.
Objective:To explore the effects of the family responsibility interactive nursing mode on the function recovery of multiple fractures of metatarsal,and nursing satisfaction degree.Methods:Sixty patients with multiple fractures of metatarsal in 2015(30 cases) and 2014(30 cases) were divided into the control group and observation group,respectively.The control group and observation group were nursed with the routine nursing mode and family responsibility interactive nursing mode,respectively.The foot function recovery,hospitalization time,health knowledge and incidence of complications between two groups were compared.All patients were followed up.Results:No complication in two groups was found.The hospitalization time in observation group was less than that in control group(P < 0.01),the excellent and good rate of foot function recovery in observation group was better than that in control group(P<0.01),and the mastering healthy knowledge in observation group was better than that in control group(P<0.01).Conclusions:The application of the family responsibility interactive nursing mode in the multiple fractures of metatarsal can promote the wound healing,and quickly recover the foot function.This nursing mode has higher satisfaction in patients,which is worthy of promotion in clinic.
2017, 42(8): 1125-1127.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.035
Abstract:
Objective:To investigate the application effects of real-cause intervention in the management of pediatric deep burn scar.Methods:A total of 60 cases were selected in the 1-6 years of deep burn rehabilitation,of which 30 were treated as control group in October to December 2015,and 30 cases were treated as observation groups in March to April 2016.The control group was implemented with routine rehabilitation scar management guidance,and the observation group was implemented with real-cause intervention scar management guidance.The implementation rate of scar management,degree of scar hyperplasia,muscle contracture and joint dysfunction between two groups were compared.Results:At discharge and after 6 months of discharge,the implementation rate of scar management in observation group was significantly higher than that in control group(P<0.01),and the degree of scar hyperplasia,muscle contracture and joint dysfunction in observation group were better than those in control group(P<0.05 to P<0.01).Conclusions:The real-cause intervention in the management of pediatric deep burn scar can improve the implementation rate of scar management,and reduce the degrees of scar hyperplasia,muscle contracture and joint dysfunction.
Objective:To investigate the application effects of real-cause intervention in the management of pediatric deep burn scar.Methods:A total of 60 cases were selected in the 1-6 years of deep burn rehabilitation,of which 30 were treated as control group in October to December 2015,and 30 cases were treated as observation groups in March to April 2016.The control group was implemented with routine rehabilitation scar management guidance,and the observation group was implemented with real-cause intervention scar management guidance.The implementation rate of scar management,degree of scar hyperplasia,muscle contracture and joint dysfunction between two groups were compared.Results:At discharge and after 6 months of discharge,the implementation rate of scar management in observation group was significantly higher than that in control group(P<0.01),and the degree of scar hyperplasia,muscle contracture and joint dysfunction in observation group were better than those in control group(P<0.05 to P<0.01).Conclusions:The real-cause intervention in the management of pediatric deep burn scar can improve the implementation rate of scar management,and reduce the degrees of scar hyperplasia,muscle contracture and joint dysfunction.
2017, 42(8): 1128-1130,1133.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.036
Abstract:
Objective:To investigate the clinical effects of the oral care intervention on periodontal health in pregnant women.Methods:The periodontal health in 1 176 pregnant women of Futian District from January 2014 to November 2015 was investigated.The periodontal health in 560 pregnant women was compared between before and after oral care intervention,and the care effect was observed.Results:The low education level,low monthly income,using non-drug toothpaste,brushing teeth once a day,brushing time less than 1 min,body mass index more than 25.0 kg/m2,non-seeing a doctor before 1 year of pregnancy,no habit of cleaning teeth,unknowing the brushing teeth rule and non-using mouthwash were the risk factors of the periodontal problems in pregnant women(P<0.05 to P<0.01).The oral care intervention could significantly improve the periodontal health of pregnant women(P<0.01).Conclusions:Based on the periodontal health care,strengthening the oral care intervention can further reduce the incidence of periodontal problems in pregnant women.
Objective:To investigate the clinical effects of the oral care intervention on periodontal health in pregnant women.Methods:The periodontal health in 1 176 pregnant women of Futian District from January 2014 to November 2015 was investigated.The periodontal health in 560 pregnant women was compared between before and after oral care intervention,and the care effect was observed.Results:The low education level,low monthly income,using non-drug toothpaste,brushing teeth once a day,brushing time less than 1 min,body mass index more than 25.0 kg/m2,non-seeing a doctor before 1 year of pregnancy,no habit of cleaning teeth,unknowing the brushing teeth rule and non-using mouthwash were the risk factors of the periodontal problems in pregnant women(P<0.05 to P<0.01).The oral care intervention could significantly improve the periodontal health of pregnant women(P<0.01).Conclusions:Based on the periodontal health care,strengthening the oral care intervention can further reduce the incidence of periodontal problems in pregnant women.
2017, 42(8): 1131-1133.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.037
Abstract:
Objective:To investigate the application value of the stage debugging of anesthesia nurses in labor analgesia.Methods:One hundred puerperas with painless childbirth were randomly divided into the control group and support group according to the labor analgesia.The control group and support group were treated with routine nursing care and perinatal stage debugging of anesthesia nurses in labor analgesia,respectively.The degree of pain(at full dilatation of portio),average total amount of drugs by intravenous analgesia,press time and duration of labor in two groups were recorded and compared.Results:The degree of pain,average total amount of drugs by intravenous analgesia and press time in support group were significantly less than those in control group(P<0.01).The duration of the first and second stage of labor in support group were shorter than those in control group(P<0.01 and P<0.05),but the duration of the third stage of labor did not shorten in support group.Conclusions:The stage debugging of anesthesia nurses in labor analgesia can improve the childbirth analgesia effect,reduce the dose of intravenous analgesia drug and shorten labor time,which can be widely used in clinic.
Objective:To investigate the application value of the stage debugging of anesthesia nurses in labor analgesia.Methods:One hundred puerperas with painless childbirth were randomly divided into the control group and support group according to the labor analgesia.The control group and support group were treated with routine nursing care and perinatal stage debugging of anesthesia nurses in labor analgesia,respectively.The degree of pain(at full dilatation of portio),average total amount of drugs by intravenous analgesia,press time and duration of labor in two groups were recorded and compared.Results:The degree of pain,average total amount of drugs by intravenous analgesia and press time in support group were significantly less than those in control group(P<0.01).The duration of the first and second stage of labor in support group were shorter than those in control group(P<0.01 and P<0.05),but the duration of the third stage of labor did not shorten in support group.Conclusions:The stage debugging of anesthesia nurses in labor analgesia can improve the childbirth analgesia effect,reduce the dose of intravenous analgesia drug and shorten labor time,which can be widely used in clinic.
2017, 42(8): 1134-1136,1139.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.038
Abstract:
Objective:To explore the effects of staging pertinent nursing intervention on muscle strength,quality of life and treatment compliance in hemiplegia patients with cerebral infarction.Methods:One hundred and twenty hemiplegia patients with cerebral infarction were randomly divided into control group and observation group using the random number table method(60 cases each group).The control group and observation group were given the conventional rehabilitation nursing and staging pertinent nursing intervention,respectively.The muscle strength,NIHSS score,Barthel index score,quality of life and treatment compliance between before and after invention in two groups were compared.Results:The differences of the muscle strength,NIHSS score and Barthel index score before intervention between two groups were not statistically significant(P>0.05).Compared with before intervention,the muscle strength and Barthel index score significantly increased(P<0.01),the NIHSS score significantly decreased in two groups after intervention(P<0.01),and the improvement of which in observation group was significantly better than that in control group(P<0.01).The difference of the total compliance rate before intervention between two groups was not statistically significant(P>0.05).Compared with before intervention,the treatment compliance rate in two groups increased after intervention,and the total compliance rate in observation group(95.00%) was significantly higher than that in control group(83.33%)(P<0.01).The difference of the quality of life score before intervention between two groups was not statistically significant(P>0.05).Compared with before intervention,the quality of life score in two groups significantly increased after intervention(P<0.01),and the increasing degree of the quality of life score in observation group was more obvious than that in control group(P<0.01).Conclusions:The staging pertinent nursing intervention can significantly improve the muscle strength,neurological function,ability of daily life,quality of life and treatment compliance in hemiplegia patients with cerebral infarction.
Objective:To explore the effects of staging pertinent nursing intervention on muscle strength,quality of life and treatment compliance in hemiplegia patients with cerebral infarction.Methods:One hundred and twenty hemiplegia patients with cerebral infarction were randomly divided into control group and observation group using the random number table method(60 cases each group).The control group and observation group were given the conventional rehabilitation nursing and staging pertinent nursing intervention,respectively.The muscle strength,NIHSS score,Barthel index score,quality of life and treatment compliance between before and after invention in two groups were compared.Results:The differences of the muscle strength,NIHSS score and Barthel index score before intervention between two groups were not statistically significant(P>0.05).Compared with before intervention,the muscle strength and Barthel index score significantly increased(P<0.01),the NIHSS score significantly decreased in two groups after intervention(P<0.01),and the improvement of which in observation group was significantly better than that in control group(P<0.01).The difference of the total compliance rate before intervention between two groups was not statistically significant(P>0.05).Compared with before intervention,the treatment compliance rate in two groups increased after intervention,and the total compliance rate in observation group(95.00%) was significantly higher than that in control group(83.33%)(P<0.01).The difference of the quality of life score before intervention between two groups was not statistically significant(P>0.05).Compared with before intervention,the quality of life score in two groups significantly increased after intervention(P<0.01),and the increasing degree of the quality of life score in observation group was more obvious than that in control group(P<0.01).Conclusions:The staging pertinent nursing intervention can significantly improve the muscle strength,neurological function,ability of daily life,quality of life and treatment compliance in hemiplegia patients with cerebral infarction.
2017, 42(8): 1137-1139.
doi: 10.13898/j.cnki.issn.1000-2200.2017.08.039
Abstract:
Objective:To investigate the effects of simethicone combined with compound polyethylene glycol in preoperative bowel preparation of colonoscopy.Methods:One hundred and eighty-six patients scheduled by colonoscopy were divided into the observation group and control group according to the random number table(93 cases each group).The less residue semi-liquid food was used in two groups in preoperative 1 d,and the fasting breakfast and lunch in two groups were implemented at check day.Before operation,the control group was treated with compound polyethylene glycol,and the observation group was treated with dimethicone based on the control group.The intestinal cleaning,intestinal air bubble and adverse reactions between two groups were compared.Results:The excellent and good rate of intestinal cleaning in observation group(97.85%) was higher than that in control group(88.17%) (P<0.05).The excellent and good rate of intestinal air bubble in observation group(96.77%) was higher than that in control group(84.95%)(P<0.01).The incidence rates of abdominal pain,bloating,nausea and vomiting in observation group were lower than those in control group(P<0.05).Conclusions:The application of compound polyethylene glycol combined with simethicone in preoperative bowel preparation of colonoscopy has good cleaning effect,less adverse reaction,and is safe,which can help to remove the bubble of gut.
Objective:To investigate the effects of simethicone combined with compound polyethylene glycol in preoperative bowel preparation of colonoscopy.Methods:One hundred and eighty-six patients scheduled by colonoscopy were divided into the observation group and control group according to the random number table(93 cases each group).The less residue semi-liquid food was used in two groups in preoperative 1 d,and the fasting breakfast and lunch in two groups were implemented at check day.Before operation,the control group was treated with compound polyethylene glycol,and the observation group was treated with dimethicone based on the control group.The intestinal cleaning,intestinal air bubble and adverse reactions between two groups were compared.Results:The excellent and good rate of intestinal cleaning in observation group(97.85%) was higher than that in control group(88.17%) (P<0.05).The excellent and good rate of intestinal air bubble in observation group(96.77%) was higher than that in control group(84.95%)(P<0.01).The incidence rates of abdominal pain,bloating,nausea and vomiting in observation group were lower than those in control group(P<0.05).Conclusions:The application of compound polyethylene glycol combined with simethicone in preoperative bowel preparation of colonoscopy has good cleaning effect,less adverse reaction,and is safe,which can help to remove the bubble of gut.
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