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2018 Vol. 43, No. 11
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2018, 43(11): 1401-1404.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.001
Abstract:
Objective: To investigate the effects of virus macrophage inflammatory protein-Ⅱ(vMIP-Ⅱ) N-terminal 21 amino acids peptide(NT21MP) on the expression profiles of miRNAs in breast cancer MCF-7 cell.Methods: The RNA in each group cells was extracted,and transcribed into cDNA.The experiment was designed according to the 2-△△Ct analytical method,and the miRNA expression profile was analyzed using the quantitative analysis of SYBR Green I.Results: A total of 168 miRNAs genes were detected,and the genes of expression upregulating two-fold or downregulating 0.5-fold were screened.Compared with the S group,the expression levels of miR-223-3p,miR-451a,miR-128,miR-489,miR-141-3p,miR-320a,miR-155-3p,miR-335-3p and miR-320e increased,and the expression levels of miR-15a-5p and miR-339-5p decreased in N group.Conclusions: The differential expression profiles of miRNAs regulated by NT21MP were screened to provide a basis for studyiny the mechanism of miRNAs in th regulation of NT21MP.
Objective: To investigate the effects of virus macrophage inflammatory protein-Ⅱ(vMIP-Ⅱ) N-terminal 21 amino acids peptide(NT21MP) on the expression profiles of miRNAs in breast cancer MCF-7 cell.Methods: The RNA in each group cells was extracted,and transcribed into cDNA.The experiment was designed according to the 2-△△Ct analytical method,and the miRNA expression profile was analyzed using the quantitative analysis of SYBR Green I.Results: A total of 168 miRNAs genes were detected,and the genes of expression upregulating two-fold or downregulating 0.5-fold were screened.Compared with the S group,the expression levels of miR-223-3p,miR-451a,miR-128,miR-489,miR-141-3p,miR-320a,miR-155-3p,miR-335-3p and miR-320e increased,and the expression levels of miR-15a-5p and miR-339-5p decreased in N group.Conclusions: The differential expression profiles of miRNAs regulated by NT21MP were screened to provide a basis for studyiny the mechanism of miRNAs in th regulation of NT21MP.
2018, 43(11): 1405-1407,1410.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.002
Abstract:
Objective: To investigate the effects of inhibiting MAPK pathway on the injured hippocampal neurons induced by status epilepticus in rats and its mechanism.Methods: Thirty rats were randomly divided into the control group,model group and drug group.The status epilepticus model of rats was established using lithium pilocarpine,and the 0.05 mg/kg of SCH58261 was intraperitoneally injected into rats in the drug group before 15 minutes of the lithium pilocarpine injection.After 24 hours,the neurons in the hippocampal CA3 region of rats were observed,and the expression levels of p-p38,p-ERK and p-JNK proteins were detected.Results: Compared with the model group,the epileptic seizures degree in drug group was significantly lighter(P<0.05).A large number of neuron degeneration and necrosis were observed in region in the model group.Most of the cells swelled,the cell volume increased,the cell edge was not clear,the cell nuclei was pyknosis,broken and dissolved,and the cell loss was obvious.Compared with the model group,the neuron loss in CA3 region was less,the degeneration of neurons was not obvious,and the amount of Nissl body decreasing was less in drug group.The expressions of p-JNK,p38 and p-ERK were found in hippocampus of three group,the expressions of p-JNK,p-p38 and p-ERK increased in model group,the expression levels of p-p38 and p-JNK in drug group were less than those in model group(P<0.01),and the difference of the expression level of p-ERK between the model group and drug group was not statistically significant(P>0.05).Conclusions: The status epilepticus in rats can lead to the hippocampal neurons damage,and the SCH58261(adenosine A2A receptor blocker) can protect the hippocampal neurons by inhibiting the MAPK pathway.
Objective: To investigate the effects of inhibiting MAPK pathway on the injured hippocampal neurons induced by status epilepticus in rats and its mechanism.Methods: Thirty rats were randomly divided into the control group,model group and drug group.The status epilepticus model of rats was established using lithium pilocarpine,and the 0.05 mg/kg of SCH58261 was intraperitoneally injected into rats in the drug group before 15 minutes of the lithium pilocarpine injection.After 24 hours,the neurons in the hippocampal CA3 region of rats were observed,and the expression levels of p-p38,p-ERK and p-JNK proteins were detected.Results: Compared with the model group,the epileptic seizures degree in drug group was significantly lighter(P<0.05).A large number of neuron degeneration and necrosis were observed in region in the model group.Most of the cells swelled,the cell volume increased,the cell edge was not clear,the cell nuclei was pyknosis,broken and dissolved,and the cell loss was obvious.Compared with the model group,the neuron loss in CA3 region was less,the degeneration of neurons was not obvious,and the amount of Nissl body decreasing was less in drug group.The expressions of p-JNK,p38 and p-ERK were found in hippocampus of three group,the expressions of p-JNK,p-p38 and p-ERK increased in model group,the expression levels of p-p38 and p-JNK in drug group were less than those in model group(P<0.01),and the difference of the expression level of p-ERK between the model group and drug group was not statistically significant(P>0.05).Conclusions: The status epilepticus in rats can lead to the hippocampal neurons damage,and the SCH58261(adenosine A2A receptor blocker) can protect the hippocampal neurons by inhibiting the MAPK pathway.
2018, 43(11): 1408-1410.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.003
Abstract:
Objective: To establish the mouse model of hepatocellular carcinoma using rapid and vast tail vein injection.Methods: The mixed solution(2 mL) of transposon plasmid NRASV12 inserted by NRAS gene,transposon plasmid expressing activated AKT(myr-Akt) and transposase SB100 was injected into the tail vein of mice within 7 s(observation group).Mouse injected with the same volume saline was set as the control group.After 3 to 4 weeks of injection,the mice of the two groups were sacrificed,and the tumor formation was examined by pathology.Results: The tumor formation rate in observation group was 100%(24/24),and the hepatocellular carcinoma was identified by pathology.No tumor formation in control group was found.Conclusions: Establishment of the mouse model of hepatocellular carcinoma using rapid and vast tail vein injection is simple,has short cancer-inducing time,high success rate and good repeatability.
Objective: To establish the mouse model of hepatocellular carcinoma using rapid and vast tail vein injection.Methods: The mixed solution(2 mL) of transposon plasmid NRASV12 inserted by NRAS gene,transposon plasmid expressing activated AKT(myr-Akt) and transposase SB100 was injected into the tail vein of mice within 7 s(observation group).Mouse injected with the same volume saline was set as the control group.After 3 to 4 weeks of injection,the mice of the two groups were sacrificed,and the tumor formation was examined by pathology.Results: The tumor formation rate in observation group was 100%(24/24),and the hepatocellular carcinoma was identified by pathology.No tumor formation in control group was found.Conclusions: Establishment of the mouse model of hepatocellular carcinoma using rapid and vast tail vein injection is simple,has short cancer-inducing time,high success rate and good repeatability.
2018, 43(11): 1411-1414.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.004
Abstract:
Objective: To establish and identify the culture model of annulus fibrosus(AF) cells of rabbit in vitro for providing the theoretical basis in further studying the intervertebral disc degeneration.Methods: The primary AF cells were obtained using enzyme digestion method,and the AF cells after passage were purified using gradient centrifugation technique and natural digestion method.The cytological characteristics of AF cells were observed,the growth curve of cells was drew by MTT assay.The expression levels of type Ⅰ and Ⅱ collagen in AF cells were measured using immunofluorescence combined with Hoechst nuclear staining,and the AF cells were identified.Results: The firstly adherent AF cells was round,and soon extended for the short spindle.After passage,the cells was long spindle or polygon,and began to age after fourth generation,and the expressions of type Ⅰand Ⅱ collagen in AF cells were found.Conclusions: The AF cells of rabbit are successfully cultured in vitro,which can provide the basis in further studying the occurrence and development mechanism of intervertebral disc degeneration.
Objective: To establish and identify the culture model of annulus fibrosus(AF) cells of rabbit in vitro for providing the theoretical basis in further studying the intervertebral disc degeneration.Methods: The primary AF cells were obtained using enzyme digestion method,and the AF cells after passage were purified using gradient centrifugation technique and natural digestion method.The cytological characteristics of AF cells were observed,the growth curve of cells was drew by MTT assay.The expression levels of type Ⅰ and Ⅱ collagen in AF cells were measured using immunofluorescence combined with Hoechst nuclear staining,and the AF cells were identified.Results: The firstly adherent AF cells was round,and soon extended for the short spindle.After passage,the cells was long spindle or polygon,and began to age after fourth generation,and the expressions of type Ⅰand Ⅱ collagen in AF cells were found.Conclusions: The AF cells of rabbit are successfully cultured in vitro,which can provide the basis in further studying the occurrence and development mechanism of intervertebral disc degeneration.
2018, 43(11): 1415-1418.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.005
Abstract:
Objective: To investigate the application value of regional hepatic vascular exclusion in hepatectomy.Methods: The clinical data of 54 patients treated with hepatectomy were retrospectively analyzed.The patients treated with hepatectomy were divided into the group A(24 cases) and group B(30 cases) according to the different operation techniques.group A and group B were treated with regional hepatic vascular exclusion and Pringle hepatic vascular exclusion,respectively.Results: The differences of the operation time,intraoperative bleeding,hepatic portal blood flow blocked time and postoperative 24 h peritoneal drainage between two groups were statistically significant(P<0.05 to P<0.01).The difference of the incidence rate of complication between two groups was not statistically significant(P>0.05).No perioperative death occurred in two groups.Conclusions: The technique of regional hepatic vascular exclusion in hepatectomy can significantly reduce the intraoperative blood loss,liver damage and liver ischemia-reperfusion injury,which is a better way to control blood loss in hepatectomy.
Objective: To investigate the application value of regional hepatic vascular exclusion in hepatectomy.Methods: The clinical data of 54 patients treated with hepatectomy were retrospectively analyzed.The patients treated with hepatectomy were divided into the group A(24 cases) and group B(30 cases) according to the different operation techniques.group A and group B were treated with regional hepatic vascular exclusion and Pringle hepatic vascular exclusion,respectively.Results: The differences of the operation time,intraoperative bleeding,hepatic portal blood flow blocked time and postoperative 24 h peritoneal drainage between two groups were statistically significant(P<0.05 to P<0.01).The difference of the incidence rate of complication between two groups was not statistically significant(P>0.05).No perioperative death occurred in two groups.Conclusions: The technique of regional hepatic vascular exclusion in hepatectomy can significantly reduce the intraoperative blood loss,liver damage and liver ischemia-reperfusion injury,which is a better way to control blood loss in hepatectomy.
2018, 43(11): 1418-1420.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.006
Abstract:
Objective: To investigate the application value of anti-mullerian hormone(AMH) in the evaluation of ovarian reserve function.Methods: One hundred and fifty-seven patients with infertility were investigated.According to the antral follicle count(AFC) detected by transvaginal ultrasonography on the third day of menstruation,the patients were divided into the observation group(AFC<5) and control group(AFC ≥ 5).The serum levels of AMH and reproductive hormone in two groups were measured using Cobas e411 automatic electrochemical luminescence immunoanalyzer,the result of which was compared.Results: There were statistical significance's in the levels of AMH,luteinizing hormone,follicle stimulating hormone FSH and estradiol(E2) between two groups(P<0.01).There was no statistical significance in the levels of testosterone between two groups(P>0.05).Pearson correlation analysis showed that the AMH level was positively correlated with the levels of AFC and E2,and negatively correlated with the patient's age and FSH level.Conclusions: The serum AMH level combined with AFC and basic reproductive hormone levels can predict and evaluate the ovarian reserve function.The change of AMH level is earlier than that of basic reproductive hormone level,which can more early and more accurately predict the change of ovarian reserve capacity.
Objective: To investigate the application value of anti-mullerian hormone(AMH) in the evaluation of ovarian reserve function.Methods: One hundred and fifty-seven patients with infertility were investigated.According to the antral follicle count(AFC) detected by transvaginal ultrasonography on the third day of menstruation,the patients were divided into the observation group(AFC<5) and control group(AFC ≥ 5).The serum levels of AMH and reproductive hormone in two groups were measured using Cobas e411 automatic electrochemical luminescence immunoanalyzer,the result of which was compared.Results: There were statistical significance's in the levels of AMH,luteinizing hormone,follicle stimulating hormone FSH and estradiol(E2) between two groups(P<0.01).There was no statistical significance in the levels of testosterone between two groups(P>0.05).Pearson correlation analysis showed that the AMH level was positively correlated with the levels of AFC and E2,and negatively correlated with the patient's age and FSH level.Conclusions: The serum AMH level combined with AFC and basic reproductive hormone levels can predict and evaluate the ovarian reserve function.The change of AMH level is earlier than that of basic reproductive hormone level,which can more early and more accurately predict the change of ovarian reserve capacity.
2018, 43(11): 1421-1424.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.007
Abstract:
Objective: To evaluate the clinical effects of the microscopic excision guided by sodium fluorescein in recurrent glioma.Methods: Among 46 recurrent glioma patients treated with operation,the tumors in 21 cases were excised with microscopic excision after the range of tumor was identified using sodium fluorescein guidance(sodium fluorescein guidance group),and 25 cases were excised with conventional microscopic resection(traditional operation group).The ranges of tumor resection in two groups were identified using MRI enhanced scan after operation.Results: The yellow fluorescence in recurrent glioma of sodium fluorescein guidance group were found under fluorescence microscope,the pathological results showed that a lot of glioma cells located in yellow fluorescence area,and the postoperative MRI enhanced scan results showed that the tumor was thoroughly resected.The total resection rate in sodium fluorescein guidance group(91.7%) was higher than that in traditional operation group(65.3%)(P<0.05).The KPS score in fluoresce sodium guidance group[(80.6±5.7] was higher than that in traditional operation group[(75.6±6.3)](P<0.01).Conclusions: The microscopic excision guided by sodium fluorescein in recurrent glioma can accurately determine the tumor boundary,improve the rate of tumor resection rate and protect the normal brain tissue.
Objective: To evaluate the clinical effects of the microscopic excision guided by sodium fluorescein in recurrent glioma.Methods: Among 46 recurrent glioma patients treated with operation,the tumors in 21 cases were excised with microscopic excision after the range of tumor was identified using sodium fluorescein guidance(sodium fluorescein guidance group),and 25 cases were excised with conventional microscopic resection(traditional operation group).The ranges of tumor resection in two groups were identified using MRI enhanced scan after operation.Results: The yellow fluorescence in recurrent glioma of sodium fluorescein guidance group were found under fluorescence microscope,the pathological results showed that a lot of glioma cells located in yellow fluorescence area,and the postoperative MRI enhanced scan results showed that the tumor was thoroughly resected.The total resection rate in sodium fluorescein guidance group(91.7%) was higher than that in traditional operation group(65.3%)(P<0.05).The KPS score in fluoresce sodium guidance group[(80.6±5.7] was higher than that in traditional operation group[(75.6±6.3)](P<0.01).Conclusions: The microscopic excision guided by sodium fluorescein in recurrent glioma can accurately determine the tumor boundary,improve the rate of tumor resection rate and protect the normal brain tissue.
2018, 43(11): 1424-1427.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.008
Abstract:
Objective: To investigate the effects of the radical resection of ovarian cancer with ovarian function reservation on the prognosis of patients with cervical cancer.Methods: Three hundred and fifty-eight patients with cervical cancer were divided into the observation group(83 cases) and control group(275 cases).The observation group and control group were treated with the radical resection of ovarian cancer with and without ovarian function reservation,respectively.After 3 and 6 months of operation,the serum levels of sex hormone in two groups were detected.After 6 months of operation,and the quality of life in two groups was investigated using Kupperman score,and the TCT and imaging examinations in two groups were regularly performed after operation.Results: After 6 months of operation,the modified Kupperman score in observation group was significantly lower than that in control group(P<0.01).After 3 and 6 months of operation,the levels of FSH,LH and E2 in observation group were normal,and only 3 cases with ovarian failure were found.After 3 and 6 months of operation,the levels of FSH and LH in control group were significantly higher than those in observation group(P<0.01),and the level of E2 in control group was significantly lower than that in observation group(P<0.01).The observation group was followed up,and the ovarian metastasis in 2 cases,ovarian abscess in 4 cases,residual ovarian syndrome in 1 case and ovarian transplantation pain in 3 cases were identified.Conclusions: The reservation of single/bilateral ovary in cervical cancer patients who is eligible to retain ovarian function,is feasible.Preserving ovarian function can improve the quality of life,the intraoperative ovarian preservation is safe,and few patients appear ovarian metastasis.
Objective: To investigate the effects of the radical resection of ovarian cancer with ovarian function reservation on the prognosis of patients with cervical cancer.Methods: Three hundred and fifty-eight patients with cervical cancer were divided into the observation group(83 cases) and control group(275 cases).The observation group and control group were treated with the radical resection of ovarian cancer with and without ovarian function reservation,respectively.After 3 and 6 months of operation,the serum levels of sex hormone in two groups were detected.After 6 months of operation,and the quality of life in two groups was investigated using Kupperman score,and the TCT and imaging examinations in two groups were regularly performed after operation.Results: After 6 months of operation,the modified Kupperman score in observation group was significantly lower than that in control group(P<0.01).After 3 and 6 months of operation,the levels of FSH,LH and E2 in observation group were normal,and only 3 cases with ovarian failure were found.After 3 and 6 months of operation,the levels of FSH and LH in control group were significantly higher than those in observation group(P<0.01),and the level of E2 in control group was significantly lower than that in observation group(P<0.01).The observation group was followed up,and the ovarian metastasis in 2 cases,ovarian abscess in 4 cases,residual ovarian syndrome in 1 case and ovarian transplantation pain in 3 cases were identified.Conclusions: The reservation of single/bilateral ovary in cervical cancer patients who is eligible to retain ovarian function,is feasible.Preserving ovarian function can improve the quality of life,the intraoperative ovarian preservation is safe,and few patients appear ovarian metastasis.
2018, 43(11): 1428-1430.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.009
Abstract:
Objective: To analyze the characteristics of brain electrical activity detected by amplitude-integrated electroencephalogram(aEEG) in preterm infants with different gestational ages.Methods: One hundred and thirty-five preterm infants with gestational age 27-36+6 weeks were divided into the <28 weeks,28-29+6 weeks,30-31+6 weeks,32-33+6 weeks and 34-36+6 weeks groups according to the gestational age.The first aEEG monitoring was performed for 8 h in all cases after 3 to 5 days of birth.The changes of voltage continuity,upper and lower borders,and sleep-wake cycle were analyzed.Results: Among the preterm infants with gestational age <28 weeks,the discontinuous voltage was found,and periodic changes in sleep was not found.With the increasing of gestational age,the ratio of continuous voltage and sleep periodicity gradually increased(P<0.01).With the increasing of gestational age,the upper amplitude value of active sleep period,lower amplitude value of active sleep period and course of one sleep cycle gradually decreased,increased and shortened,respectively(P<0.01).Conclusions: The aEEG can better reflect the brain maturation of preterm infants,and the EEG background activity in the preterm infants with older gestational age is more mature.The aEEG has a better assessment value in brain function prognosis of preterm infants.
Objective: To analyze the characteristics of brain electrical activity detected by amplitude-integrated electroencephalogram(aEEG) in preterm infants with different gestational ages.Methods: One hundred and thirty-five preterm infants with gestational age 27-36+6 weeks were divided into the <28 weeks,28-29+6 weeks,30-31+6 weeks,32-33+6 weeks and 34-36+6 weeks groups according to the gestational age.The first aEEG monitoring was performed for 8 h in all cases after 3 to 5 days of birth.The changes of voltage continuity,upper and lower borders,and sleep-wake cycle were analyzed.Results: Among the preterm infants with gestational age <28 weeks,the discontinuous voltage was found,and periodic changes in sleep was not found.With the increasing of gestational age,the ratio of continuous voltage and sleep periodicity gradually increased(P<0.01).With the increasing of gestational age,the upper amplitude value of active sleep period,lower amplitude value of active sleep period and course of one sleep cycle gradually decreased,increased and shortened,respectively(P<0.01).Conclusions: The aEEG can better reflect the brain maturation of preterm infants,and the EEG background activity in the preterm infants with older gestational age is more mature.The aEEG has a better assessment value in brain function prognosis of preterm infants.
2018, 43(11): 1431-1433,1436.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.010
Abstract:
Objective: To explore the clinical effects of caffeine citrate and aminophylline in the treatment of apnea in of prematurity.Methods: Sixty-five premature infants with apnea from March 2014 to August 2015 were treated with conventional method(including keeping the correct position,massaging back and playing a foot) combined with drug.Thirty-five cases were treated with caffeine citrate(caffeine citrate group),and 30 cases were treated with aminophylline(aminophylline group).The time of non-invasive mechanical ventilation,time of invasive mechanical ventilation,oxygen time and incidence rate of complication between two groups were compared.Results: The time of non-invasive mechanical ventilation,time of invasive mechanical ventilation and oxygen time in caffeine citrate group were shorter than those in aminophylline group(P<0.01),and the incidence rate of bronchial dysplasia in caffeine citrate group was lower than that in aminophylline group(P<0.05).The differences of the incidence rates of retinopathy,intraventricular hemorrhage,leukomalacia and necrotizing enterocolitis of newborn between two groups were not statistically significant(P>0.05).Conclusions: Caffeine citrate can reduce the time of non-invasive mechanical ventilation,invasive mechanical ventilation time,oxygen time and incidence rate of bronchial dysplasia in premature infant with apnea.
Objective: To explore the clinical effects of caffeine citrate and aminophylline in the treatment of apnea in of prematurity.Methods: Sixty-five premature infants with apnea from March 2014 to August 2015 were treated with conventional method(including keeping the correct position,massaging back and playing a foot) combined with drug.Thirty-five cases were treated with caffeine citrate(caffeine citrate group),and 30 cases were treated with aminophylline(aminophylline group).The time of non-invasive mechanical ventilation,time of invasive mechanical ventilation,oxygen time and incidence rate of complication between two groups were compared.Results: The time of non-invasive mechanical ventilation,time of invasive mechanical ventilation and oxygen time in caffeine citrate group were shorter than those in aminophylline group(P<0.01),and the incidence rate of bronchial dysplasia in caffeine citrate group was lower than that in aminophylline group(P<0.05).The differences of the incidence rates of retinopathy,intraventricular hemorrhage,leukomalacia and necrotizing enterocolitis of newborn between two groups were not statistically significant(P>0.05).Conclusions: Caffeine citrate can reduce the time of non-invasive mechanical ventilation,invasive mechanical ventilation time,oxygen time and incidence rate of bronchial dysplasia in premature infant with apnea.
2018, 43(11): 1434-1436.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.011
Abstract:
Objective: To research the efficacy and advantage of laparoscopic pyloromyotomy(LP) and open right upper quadrant small incision pyloromyotomy(OP) for the treatment of congenital hypertrophic pyloric stenosis.Methods: Eighty-five patients with congenital hypertrophic pyloric stenosis were divided into LP group(35 cases) and OP group(50 cases). The perioperative,postoperative,and related complications between two groups were compared.Results: The operation time,blood loss during operation and hospitalization time in LP group were obviously lower than those in OP group(P<0.01). The difference of delayed wound healing in two groups was not statistically significant(P>0.05).Conclusions: LP is safe,effective and feasible for hypertrophic pyloric stenosis with mini-invasion,little injury,little blood loss,quick recovery,short operation time and hospitalization time,which is worthy of clinical promotion.
Objective: To research the efficacy and advantage of laparoscopic pyloromyotomy(LP) and open right upper quadrant small incision pyloromyotomy(OP) for the treatment of congenital hypertrophic pyloric stenosis.Methods: Eighty-five patients with congenital hypertrophic pyloric stenosis were divided into LP group(35 cases) and OP group(50 cases). The perioperative,postoperative,and related complications between two groups were compared.Results: The operation time,blood loss during operation and hospitalization time in LP group were obviously lower than those in OP group(P<0.01). The difference of delayed wound healing in two groups was not statistically significant(P>0.05).Conclusions: LP is safe,effective and feasible for hypertrophic pyloric stenosis with mini-invasion,little injury,little blood loss,quick recovery,short operation time and hospitalization time,which is worthy of clinical promotion.
2018, 43(11): 1437-1439.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.012
Abstract:
Objective: To explore the association of red cell distribution width(RDM) with acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score,sequential organ failure assessment(SOFA) score,and prognosis of pneumonia patients complicated with septic shock.Methods: According to the case-control study,the clinical data in 86 pneumonia patients complicated with septic shock were retrospectively analyzed,and divided into the survival group(n=50) and death group(n=36) according to the 28-day prognosis.The RDW,white blood cell(WBC) count,hemoglobin(Hb),platelet(PLT) count,hematokrit(HCT) and platelet distribution width(PDW) were detected on admission,and the APACHE Ⅱ score and SOFA score in two groups were assessed.The relationship between RDW and other indexes,and disease severity and prognosis were evaluated.Results: The RDW in death group was significantly higher than that in survival group(P<0.01),the levels of Hb and HCT in death group were significantly lower than those in survival group(P<0.01),the differences of WBC,PLT and PDW between two groups were not statistical significance(P>0.05),and the scores of APACHE Ⅱ and SOFA in death group were significantly higher than those in survival group(P<0.01).Logistic regression analysis showed that the SOFA score(OR=1.282,95%CI 1.012-1.625,P<0.05) and RDW(OR=2.986,95%CI 1.661-5.368,P<0.01) were the independent risk factors of the death in pneumonia patients complicated with septic shock.The best cut-off value of RDW predicting the death risk of pneumonia patients complicated with septic shock was 15.05%(95%CI 0.767-0.948,P<0.01).Conclusions: RDW can be a clinical index in predicting the prognosis of pneumonia patients complicated with septic shock.The RDM examination is simple and low cost,which can be act as a complementary index.
Objective: To explore the association of red cell distribution width(RDM) with acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score,sequential organ failure assessment(SOFA) score,and prognosis of pneumonia patients complicated with septic shock.Methods: According to the case-control study,the clinical data in 86 pneumonia patients complicated with septic shock were retrospectively analyzed,and divided into the survival group(n=50) and death group(n=36) according to the 28-day prognosis.The RDW,white blood cell(WBC) count,hemoglobin(Hb),platelet(PLT) count,hematokrit(HCT) and platelet distribution width(PDW) were detected on admission,and the APACHE Ⅱ score and SOFA score in two groups were assessed.The relationship between RDW and other indexes,and disease severity and prognosis were evaluated.Results: The RDW in death group was significantly higher than that in survival group(P<0.01),the levels of Hb and HCT in death group were significantly lower than those in survival group(P<0.01),the differences of WBC,PLT and PDW between two groups were not statistical significance(P>0.05),and the scores of APACHE Ⅱ and SOFA in death group were significantly higher than those in survival group(P<0.01).Logistic regression analysis showed that the SOFA score(OR=1.282,95%CI 1.012-1.625,P<0.05) and RDW(OR=2.986,95%CI 1.661-5.368,P<0.01) were the independent risk factors of the death in pneumonia patients complicated with septic shock.The best cut-off value of RDW predicting the death risk of pneumonia patients complicated with septic shock was 15.05%(95%CI 0.767-0.948,P<0.01).Conclusions: RDW can be a clinical index in predicting the prognosis of pneumonia patients complicated with septic shock.The RDM examination is simple and low cost,which can be act as a complementary index.
2018, 43(11): 1440-1443.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.013
Abstract:
Objective: To investigate the clinical significance of low molecular weight heparin(LMWH) combined with intermittent pneumatic pressure system(IPC) in the prevention of deep venous thrombosis(DVT) of lower extremities after laparoscopic radical cervical cancer surgery.Methods: One hundred and twenty-nine cervical cancer(FIGO ⅠB1-ⅡA1) patients were randomly divided into the control group(63 cases) and observation group(66 cases.The observation group were treated with IPC after 6h of operation,and LMWH after 24 h of operation.The control group were treated with general precautions.The operation time,peroperative bleeding,postoperative risk factors,and duration for bed rest between two groups were compared.Before and after operation,the levels of PLT,PT,APTT,D-D and FIB in two groups were measured,and the lower limbs vein were examined using ultrasound.Results: There was no statistical significance in operation time,blood loss,duration for bed rest,intraoperative blood transfusion and number of people with postoperative risk factors between two groups(P>0.05).The differences of the levels of PLT,PT,APTT,FIB and D-D between two groups before operation were not statistical significance(P>0.05).After 1 to 7 days of operation,the difference of the level of PLT between two groups was not statistical significance(P>0.05),and the levels of FIB and D-D in observation group were significantly lower than those in control group(P<0.01).After 1 to 5 days of operation,the levels of PT ad APTT in observation group were lower than those in control group(P<0.05 to P<0.01).The total incidence of thrombosis in observation group(1.52%) was lower than that in control group(11.11%)(P<0.05).Conclusions: LWMH combined with IPC can significantly prevent the incidence of DVT after laparoscopic radical cervical cancer.
Objective: To investigate the clinical significance of low molecular weight heparin(LMWH) combined with intermittent pneumatic pressure system(IPC) in the prevention of deep venous thrombosis(DVT) of lower extremities after laparoscopic radical cervical cancer surgery.Methods: One hundred and twenty-nine cervical cancer(FIGO ⅠB1-ⅡA1) patients were randomly divided into the control group(63 cases) and observation group(66 cases.The observation group were treated with IPC after 6h of operation,and LMWH after 24 h of operation.The control group were treated with general precautions.The operation time,peroperative bleeding,postoperative risk factors,and duration for bed rest between two groups were compared.Before and after operation,the levels of PLT,PT,APTT,D-D and FIB in two groups were measured,and the lower limbs vein were examined using ultrasound.Results: There was no statistical significance in operation time,blood loss,duration for bed rest,intraoperative blood transfusion and number of people with postoperative risk factors between two groups(P>0.05).The differences of the levels of PLT,PT,APTT,FIB and D-D between two groups before operation were not statistical significance(P>0.05).After 1 to 7 days of operation,the difference of the level of PLT between two groups was not statistical significance(P>0.05),and the levels of FIB and D-D in observation group were significantly lower than those in control group(P<0.01).After 1 to 5 days of operation,the levels of PT ad APTT in observation group were lower than those in control group(P<0.05 to P<0.01).The total incidence of thrombosis in observation group(1.52%) was lower than that in control group(11.11%)(P<0.05).Conclusions: LWMH combined with IPC can significantly prevent the incidence of DVT after laparoscopic radical cervical cancer.
2018, 43(11): 1444-1446.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.014
Abstract:
Objective: To analyze the effects of the number of oocytes on the pregnancy outcome of in vitro fertilization and embryo transfer(IVF-ET) in women under 35 years old.Methods: From June 2015 to January 2017,the women under 35 years old treated with IVF-ET were divided into the group A(the number of oocytes less than 10),group B(the number of oocytes human chorionic gonadotropin 11 to 20) and group C(the number of oocytes more than 20) according to the number of oocytes.The effect of the number of oocytes on the pregnancy outcome of IVF-ET was analyzed.Results: The use time and number of Gn in group A were significantly higher than those in group B and group C(P<0.01),the difference of the use time of Gn between group C and group B was not statistically significant(P>0.05),and the use number of Gn in group C was significantly lower than that in group B(P<0.01).The estradiol level in group C treated with human chorionic gonadotropin was significantly higher than that in group B(P<0.01),and which in group B was significantly higher than that in group A(P<0.01).The differences of the fertilization rate,high quality embryo rate,clinical pregnancy rate and planting rate among three groups were not statistically significant(P>0.05).With the increasing of the number of oocytes,the rate of ovarian hyperstimulation increased,and the difference of which was not statistically significant(P>0.05).Conclusions: In order to improve the implantation rate and clinical pregnancy rate of IVF-ET,the high-quality oocytes should enough be obtained,the effect of 11 to 20 oocytes is the best,and the individual treatment plan for different pregnant women should be formulated.
Objective: To analyze the effects of the number of oocytes on the pregnancy outcome of in vitro fertilization and embryo transfer(IVF-ET) in women under 35 years old.Methods: From June 2015 to January 2017,the women under 35 years old treated with IVF-ET were divided into the group A(the number of oocytes less than 10),group B(the number of oocytes human chorionic gonadotropin 11 to 20) and group C(the number of oocytes more than 20) according to the number of oocytes.The effect of the number of oocytes on the pregnancy outcome of IVF-ET was analyzed.Results: The use time and number of Gn in group A were significantly higher than those in group B and group C(P<0.01),the difference of the use time of Gn between group C and group B was not statistically significant(P>0.05),and the use number of Gn in group C was significantly lower than that in group B(P<0.01).The estradiol level in group C treated with human chorionic gonadotropin was significantly higher than that in group B(P<0.01),and which in group B was significantly higher than that in group A(P<0.01).The differences of the fertilization rate,high quality embryo rate,clinical pregnancy rate and planting rate among three groups were not statistically significant(P>0.05).With the increasing of the number of oocytes,the rate of ovarian hyperstimulation increased,and the difference of which was not statistically significant(P>0.05).Conclusions: In order to improve the implantation rate and clinical pregnancy rate of IVF-ET,the high-quality oocytes should enough be obtained,the effect of 11 to 20 oocytes is the best,and the individual treatment plan for different pregnant women should be formulated.
2018, 43(11): 1447-1449,1452.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.015
Abstract:
Objective: To evaluate the clinical value of high frequency electrotome conization in the treatment of high-grade cervical intraepithelial neoplasia.Methods: One hundred and seventy-two HSIL patients treated with high frequency electrotome conization and 42 HSIL patients treated with cervical loop electrosurgical excision procedure(LEEP) were divided into the observation group and control group,respectively.The intraoperative hemorrhage,postoperative hemorrhage,operation time,postoperative infection rate,postoperative cervical canal adhesion rate,positive incisal margin rate and recurrence rate in two groups were observed.Results: The difference of the operation time between the observation group[(21.02±1.81) min] and control group[(21.57±1.48) min] was not statistically significant(P>0.05).The intraoperative blood loss in observation group[(13.61±2.39) mL] was higher than that in control group[(12.60±2.08) mL](P<0.05).The positive incisal margin rate and recurrence rate in observation group(1.74% and 1.59%) were lower than those in control group(9.52% and 10.81%),respectively(P<0.05).The differences of the postoperative infection rate and postoperative cervical canal adhesion rate between two groups were not statistically significant(P>0.05).Conclusions: High frequency electrotome conization is easy to operate,and the peroperative bleeding,operation time and postoperative complication of which do not obviously improve compared with LEEP.The positive incisal margin rate and recurrence rate of high frequency electrotome conization are better than those of LEEP,and the high frequency electrotome conization can be the prior method in the treatment of cervical intraepithelial neoplasia.
Objective: To evaluate the clinical value of high frequency electrotome conization in the treatment of high-grade cervical intraepithelial neoplasia.Methods: One hundred and seventy-two HSIL patients treated with high frequency electrotome conization and 42 HSIL patients treated with cervical loop electrosurgical excision procedure(LEEP) were divided into the observation group and control group,respectively.The intraoperative hemorrhage,postoperative hemorrhage,operation time,postoperative infection rate,postoperative cervical canal adhesion rate,positive incisal margin rate and recurrence rate in two groups were observed.Results: The difference of the operation time between the observation group[(21.02±1.81) min] and control group[(21.57±1.48) min] was not statistically significant(P>0.05).The intraoperative blood loss in observation group[(13.61±2.39) mL] was higher than that in control group[(12.60±2.08) mL](P<0.05).The positive incisal margin rate and recurrence rate in observation group(1.74% and 1.59%) were lower than those in control group(9.52% and 10.81%),respectively(P<0.05).The differences of the postoperative infection rate and postoperative cervical canal adhesion rate between two groups were not statistically significant(P>0.05).Conclusions: High frequency electrotome conization is easy to operate,and the peroperative bleeding,operation time and postoperative complication of which do not obviously improve compared with LEEP.The positive incisal margin rate and recurrence rate of high frequency electrotome conization are better than those of LEEP,and the high frequency electrotome conization can be the prior method in the treatment of cervical intraepithelial neoplasia.
2018, 43(11): 1450-1452.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.016
Abstract:
Objective: To investigate the clinical effects of D2 gastric cancer radical operation assisted by laparoscopy,and its effect on abdominal micrometastasis.Methods: Ninety-two early gastric cancer patients were randomly divided into the laparoscopy group and laparotomy group(46 cases each group).The laparoscopy group and laparotomy group were treated with gastric cancer radical operation assisted by laparoscopy and laparotomy,respectively.The clinical indicators and abdominal micrometastases index before and after operation between two groups were compared.Results: The operation time in laparoscopy group was significantly longer than that in laparotomy group(P<0.01),the incision length,intraoperative blood loss,out of bed activity time,intestinal function recovery time and hospital stay in laparoscopy group were less than those in laparotomy group(P<0.05 to P<0.01),and the difference of the number of intraoperative cleaning lymph node between two groups was not statistically significant(P>0.05).The differences of the levels of dopamine decarboxylase(DDC) and carcinoembryonic antigen(CEA) between two groups before operation were not statistically significant(P>0.05).After operation,the levels of DDC and CEA in two groups were significantly higher than those of before operation(P<0.01),and the levels of DDC and CEA in laparoscopy group were lower than those in laparotomy group(P<0.01).Conclusions: The curative effect of D2 gastric cancer radical operation assisted by laparoscopy is good,which is minimally invasive and has low postoperative abdominal micrometastasis.
Objective: To investigate the clinical effects of D2 gastric cancer radical operation assisted by laparoscopy,and its effect on abdominal micrometastasis.Methods: Ninety-two early gastric cancer patients were randomly divided into the laparoscopy group and laparotomy group(46 cases each group).The laparoscopy group and laparotomy group were treated with gastric cancer radical operation assisted by laparoscopy and laparotomy,respectively.The clinical indicators and abdominal micrometastases index before and after operation between two groups were compared.Results: The operation time in laparoscopy group was significantly longer than that in laparotomy group(P<0.01),the incision length,intraoperative blood loss,out of bed activity time,intestinal function recovery time and hospital stay in laparoscopy group were less than those in laparotomy group(P<0.05 to P<0.01),and the difference of the number of intraoperative cleaning lymph node between two groups was not statistically significant(P>0.05).The differences of the levels of dopamine decarboxylase(DDC) and carcinoembryonic antigen(CEA) between two groups before operation were not statistically significant(P>0.05).After operation,the levels of DDC and CEA in two groups were significantly higher than those of before operation(P<0.01),and the levels of DDC and CEA in laparoscopy group were lower than those in laparotomy group(P<0.01).Conclusions: The curative effect of D2 gastric cancer radical operation assisted by laparoscopy is good,which is minimally invasive and has low postoperative abdominal micrometastasis.
2018, 43(11): 1453-1455,1459.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.017
Abstract:
Objective: To investigate the correlations of ankle brachial index(ABI) and intima-media thickness(IMT) with severity of coronary lesion in premature coronary artery disease(pCAD),and its early predictive value on pCAD.Methods: The ABI and carotid artery IMT in 136 pCAD patients detected by coronary angiography(CAG) were measured.The coronary score was calculated according to the degree of coronary stenosis,and the correlations of ABI and IMT with coronary score were analyzed.Results: The differences of the ABI and carotid artery IMT between single-and double-vessle lesion patients were not statistically significant(P>0.05),and the Gensini score in double-vessle lesion group was higher than that in single-vessle lesion group(P<0.05).The ABI and carotid artery IMT in three-vessle lesion group were significantly lower and higher than which in other groups,respectively(P<0.01),and the Gensini score in three-vessle lesion group was significantly higher than that in single and double-vessle lesion groups(P<0.05).The ABI value was negative correlation with the Gensini score of coronary artery(r=-0.523,P<0.01),and the carotid artery IMT was positive with correlation with the Gensini score of coronary artery(r=0.603,P<0.01).Conclusions: The ABI and carotid artery IMT have certain correlation with severity of coronary lesions in pCAD patients.The ABI significant decreasing and carotid artery IMT significant increasing can predict the severity of coronary lesion in pCAD patients.
Objective: To investigate the correlations of ankle brachial index(ABI) and intima-media thickness(IMT) with severity of coronary lesion in premature coronary artery disease(pCAD),and its early predictive value on pCAD.Methods: The ABI and carotid artery IMT in 136 pCAD patients detected by coronary angiography(CAG) were measured.The coronary score was calculated according to the degree of coronary stenosis,and the correlations of ABI and IMT with coronary score were analyzed.Results: The differences of the ABI and carotid artery IMT between single-and double-vessle lesion patients were not statistically significant(P>0.05),and the Gensini score in double-vessle lesion group was higher than that in single-vessle lesion group(P<0.05).The ABI and carotid artery IMT in three-vessle lesion group were significantly lower and higher than which in other groups,respectively(P<0.01),and the Gensini score in three-vessle lesion group was significantly higher than that in single and double-vessle lesion groups(P<0.05).The ABI value was negative correlation with the Gensini score of coronary artery(r=-0.523,P<0.01),and the carotid artery IMT was positive with correlation with the Gensini score of coronary artery(r=0.603,P<0.01).Conclusions: The ABI and carotid artery IMT have certain correlation with severity of coronary lesions in pCAD patients.The ABI significant decreasing and carotid artery IMT significant increasing can predict the severity of coronary lesion in pCAD patients.
2018, 43(11): 1456-1459.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.018
Abstract:
Objective: To observe the clinical effects of the small incision of axillary fold in treating axillary osmidrosis,analyze the histological structure of apocrine sweat glands,further clarify the distribution and range of apocrine sweat glands,and guide the operation treatment.Methods: Thirty-nine patients with osmidrosis were treated with the small incision of axillary fold(groupA).The separation range was 0.5 cm beyond the axillary hair range,the skin tissue at the center of the axilla and 0.5-1.0 cm distance from the outer edge of the axilla,the depth was down to the adipose layer,was cut and detected using histology in patients with axillary skin laxity,and the layers and range of large sweat glands in group A were observed.The incidence rate of postoperative complications in 30 patients treated with large sweat gland scratch under swelling anesthesia(group B) was retrospectively analyzed,and which was compared with that of axillary odor treated with small incision of axillary fold.Results: The total effective rates in group A and group B were 97.44% and 80%,respectively.The treatment effect in group A was better than that in group B(P<0.05),and the difference of the incidence rate of postoperative complication between two groups was not statistically significant(P>0.05).The large sweat glands were detected in group A,which was mainly distributed in the dermal layer,dermal fat junction area and fatty superficial layer.A small amount of large sweat gland tissue was found at 0.5 cm away from the edge of axillary hair,and no large sweat gland tissue was found at 1.0 cm away from the edge of axillary hair and deep adipose layer in group A.Conclusions: The small incision of axillary fold in treating axillary osmidrosis is reliable and has low postoperative recurrence rate compared with large sweat gland scratch under tumescent anesthesia,but pruning the depth and width of apocrine glands should be noted during operation,which is worthy of clinical promotion.
Objective: To observe the clinical effects of the small incision of axillary fold in treating axillary osmidrosis,analyze the histological structure of apocrine sweat glands,further clarify the distribution and range of apocrine sweat glands,and guide the operation treatment.Methods: Thirty-nine patients with osmidrosis were treated with the small incision of axillary fold(groupA).The separation range was 0.5 cm beyond the axillary hair range,the skin tissue at the center of the axilla and 0.5-1.0 cm distance from the outer edge of the axilla,the depth was down to the adipose layer,was cut and detected using histology in patients with axillary skin laxity,and the layers and range of large sweat glands in group A were observed.The incidence rate of postoperative complications in 30 patients treated with large sweat gland scratch under swelling anesthesia(group B) was retrospectively analyzed,and which was compared with that of axillary odor treated with small incision of axillary fold.Results: The total effective rates in group A and group B were 97.44% and 80%,respectively.The treatment effect in group A was better than that in group B(P<0.05),and the difference of the incidence rate of postoperative complication between two groups was not statistically significant(P>0.05).The large sweat glands were detected in group A,which was mainly distributed in the dermal layer,dermal fat junction area and fatty superficial layer.A small amount of large sweat gland tissue was found at 0.5 cm away from the edge of axillary hair,and no large sweat gland tissue was found at 1.0 cm away from the edge of axillary hair and deep adipose layer in group A.Conclusions: The small incision of axillary fold in treating axillary osmidrosis is reliable and has low postoperative recurrence rate compared with large sweat gland scratch under tumescent anesthesia,but pruning the depth and width of apocrine glands should be noted during operation,which is worthy of clinical promotion.
2018, 43(11): 1460-1462,1466.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.019
Abstract:
Objective: To investigate the effectiveness and safety of internal fixation combined with interlocking intramedullary nail under different reduction in the treatment of femoral shaft fractures.Methods: Seventy-one patients with femoral shaft fractures were divided into the open reduction group(n=34) and close reduction group(n=37) according to different reduction methods.The open reduction group and close reduction group were treated with open reduction combined with interlocking intramedullary nail fixation,and close reduction combined with interlocking intramedullary nail fixation,respectively.Two groups were followed up for 12 months.The operation index,clinical efficacy and complications were compared between two groups.Results: The intraoperative blood loss,fracture healing time in close reduction group were significantly lower than those in open reduction group(P<0.01).After 12h,24h,48h and 72h,the VAS scores in close reduction group were lower than that in open reduction group(P<0.05 to P<0.01).The clinical effect in close reduction group after 12 months of operation was better than that in open reduction group(P<0.05).The incidence rate of complication in reduction group(5.41%) was significantly lower than that in open reduction group(23.53%)(P<0.05).Conclusions: The effect of close reduction combined with interlocking intramedullary nail fixation in treating the femoral shaft fractures is better than that of open reduction.The close reduction combined with interlocking intramedullary nail fixation can promote the fracture healing and knee joint function recovery,and reduce the occurrence of complications.
Objective: To investigate the effectiveness and safety of internal fixation combined with interlocking intramedullary nail under different reduction in the treatment of femoral shaft fractures.Methods: Seventy-one patients with femoral shaft fractures were divided into the open reduction group(n=34) and close reduction group(n=37) according to different reduction methods.The open reduction group and close reduction group were treated with open reduction combined with interlocking intramedullary nail fixation,and close reduction combined with interlocking intramedullary nail fixation,respectively.Two groups were followed up for 12 months.The operation index,clinical efficacy and complications were compared between two groups.Results: The intraoperative blood loss,fracture healing time in close reduction group were significantly lower than those in open reduction group(P<0.01).After 12h,24h,48h and 72h,the VAS scores in close reduction group were lower than that in open reduction group(P<0.05 to P<0.01).The clinical effect in close reduction group after 12 months of operation was better than that in open reduction group(P<0.05).The incidence rate of complication in reduction group(5.41%) was significantly lower than that in open reduction group(23.53%)(P<0.05).Conclusions: The effect of close reduction combined with interlocking intramedullary nail fixation in treating the femoral shaft fractures is better than that of open reduction.The close reduction combined with interlocking intramedullary nail fixation can promote the fracture healing and knee joint function recovery,and reduce the occurrence of complications.
2018, 43(11): 1463-1466.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.020
Abstract:
Objective: To investigate the effects of the glomerular filtration rate(eGRF) before emergency percutaneous coronary intervention(PCI) on the prognosis of patients with ST-segment elevation myocardial infarction(STEMI).Methods: One hundred and thirty-four STEMI patients treated with PCI were divided into the low eGFR group(14cases,eGFR<60 mL·min-1·1.73 m-2) and high eGFR group(120 cases,eGFR>60 mL·min-1·1.73 m-2) according to the preoperative level of eGFR.The MIRI and incidence rate of MACE between two groups were compared.Results: The age,previous incidence of stroke,ratio of patients with Killip ≥ Ⅲ grade,levels of hs-CRP and BNP,and gensini score in low eGFR group were higher than those in high eGFR group(P<0.05 to P<0.01).The LVEF level in low eGFR group was significantly lower than that in high eGFR group(P<0.01).Compared with the high eGFR group,the incidence rates of death,restenosis and acute heart failure during hospitalization were higher in low eGFR group(P<0.01),and the differences of the incidence rates of myocardial infarction,stroke,cardiogenic death and vascular reconstruction between two groups after 1 year of PCI were not statistically significant(P<0.05).Multiple logistic regression analysis results showed that the Killip ≥ Ⅲ grade and eGFR<60 mL·min-1·1.73 m-2 was the independent risk factor for in-hospital mortality in patients with STEMI.Conclusions: The incidence rate of in-hospital MACE in STEMI patients with low eGFR is high,and also the independent risk factor for in-hospital mortality in patients with STEMI.Monitoring the level of eGFR and adjusting medicine can actively improve kidney function of patients.
Objective: To investigate the effects of the glomerular filtration rate(eGRF) before emergency percutaneous coronary intervention(PCI) on the prognosis of patients with ST-segment elevation myocardial infarction(STEMI).Methods: One hundred and thirty-four STEMI patients treated with PCI were divided into the low eGFR group(14cases,eGFR<60 mL·min-1·1.73 m-2) and high eGFR group(120 cases,eGFR>60 mL·min-1·1.73 m-2) according to the preoperative level of eGFR.The MIRI and incidence rate of MACE between two groups were compared.Results: The age,previous incidence of stroke,ratio of patients with Killip ≥ Ⅲ grade,levels of hs-CRP and BNP,and gensini score in low eGFR group were higher than those in high eGFR group(P<0.05 to P<0.01).The LVEF level in low eGFR group was significantly lower than that in high eGFR group(P<0.01).Compared with the high eGFR group,the incidence rates of death,restenosis and acute heart failure during hospitalization were higher in low eGFR group(P<0.01),and the differences of the incidence rates of myocardial infarction,stroke,cardiogenic death and vascular reconstruction between two groups after 1 year of PCI were not statistically significant(P<0.05).Multiple logistic regression analysis results showed that the Killip ≥ Ⅲ grade and eGFR<60 mL·min-1·1.73 m-2 was the independent risk factor for in-hospital mortality in patients with STEMI.Conclusions: The incidence rate of in-hospital MACE in STEMI patients with low eGFR is high,and also the independent risk factor for in-hospital mortality in patients with STEMI.Monitoring the level of eGFR and adjusting medicine can actively improve kidney function of patients.
2018, 43(11): 1467-1470.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.021
Abstract:
Objective: To compare the clinical effects between the short-term intensive insulin and metformin combined with saxagliptin in the treatment of early type 2 diabetes.Methods: One hundred and two early type 2 diabetes patients were randomly divided into the short-term intensive insulin therapy group(short-term group) and saxagliptin combined with metformin therapy group(combination group) according to the random number table method(51 cases each group).Before treatment and after 12 weeks of treatment,the levels of fasting plasma glucose(FPG),2 h postprandial glucose(2hPG),glycosylated hemoglobin(HbA1c),fasting C-peptide(FC-P),postprandial 2 h C peptide (2hC-P),fat adiponectin(ADP) and glucagon(GC) in two groups were detected,the homeostasis model insulin secretion index(HOMA-β) and insulin resistance index(HOMA-IR) in two groups were calculated,and the blood glucose standard time and hypoglycemia incidence in two groups were recorded.Results: After treatment,the levels of FPG,2hPG and HbA1c in two groups significantly decreased compared with before treatment(P<0.01),the level of HbA1c in short-term group was significantly lower than that in combination group(P<0.01),and the differences of the levels of FPG and 2hPG between two groups were not statistically significant(P>0.05).After treatment,the FC-P,2hC-P,HOMA-β and HOMA-IR in two groups were significantly improved compared with before treatment(P<0.05),and the differences of the levels of FC-P,2hC-P,HOMA-β and HOMA-IR between two groups were not statistically significant(P>0.05).The levels of GC and body mass index in combination group after treatment were significantly lower than those before treatment(P<0.01),and the differences of the levels of GC and body mass index in short-term group between before and after treatment were not statistically significant(P>0.05).After treatment,the levels of ADP in two groups significantly increased compared with before treatment(P<0.01),which in combination group was more significant than that in short-term group(P<0.01).The difference of blood glucose standard time between two groups was not statistically significant(P>0.05),and the incidence rate of hypoglycemia in short-term group was significantly higher than that in combination group(P<0.01).Conclusions: The short-term intensive insulin and saxagliptin combined with metformin in treating the early type 2 diabetes can control the level of blood glucose and improve the islet β-cell function of patients.The short-term intensive insulin can obviously reduce the HbA1c level,and the saxagliptin combined with metformin can significantly inhibit the GC level,increase the ADP level,decrease the incidence rate of hypoglycemia,and does not affect the body weight of patients.
Objective: To compare the clinical effects between the short-term intensive insulin and metformin combined with saxagliptin in the treatment of early type 2 diabetes.Methods: One hundred and two early type 2 diabetes patients were randomly divided into the short-term intensive insulin therapy group(short-term group) and saxagliptin combined with metformin therapy group(combination group) according to the random number table method(51 cases each group).Before treatment and after 12 weeks of treatment,the levels of fasting plasma glucose(FPG),2 h postprandial glucose(2hPG),glycosylated hemoglobin(HbA1c),fasting C-peptide(FC-P),postprandial 2 h C peptide (2hC-P),fat adiponectin(ADP) and glucagon(GC) in two groups were detected,the homeostasis model insulin secretion index(HOMA-β) and insulin resistance index(HOMA-IR) in two groups were calculated,and the blood glucose standard time and hypoglycemia incidence in two groups were recorded.Results: After treatment,the levels of FPG,2hPG and HbA1c in two groups significantly decreased compared with before treatment(P<0.01),the level of HbA1c in short-term group was significantly lower than that in combination group(P<0.01),and the differences of the levels of FPG and 2hPG between two groups were not statistically significant(P>0.05).After treatment,the FC-P,2hC-P,HOMA-β and HOMA-IR in two groups were significantly improved compared with before treatment(P<0.05),and the differences of the levels of FC-P,2hC-P,HOMA-β and HOMA-IR between two groups were not statistically significant(P>0.05).The levels of GC and body mass index in combination group after treatment were significantly lower than those before treatment(P<0.01),and the differences of the levels of GC and body mass index in short-term group between before and after treatment were not statistically significant(P>0.05).After treatment,the levels of ADP in two groups significantly increased compared with before treatment(P<0.01),which in combination group was more significant than that in short-term group(P<0.01).The difference of blood glucose standard time between two groups was not statistically significant(P>0.05),and the incidence rate of hypoglycemia in short-term group was significantly higher than that in combination group(P<0.01).Conclusions: The short-term intensive insulin and saxagliptin combined with metformin in treating the early type 2 diabetes can control the level of blood glucose and improve the islet β-cell function of patients.The short-term intensive insulin can obviously reduce the HbA1c level,and the saxagliptin combined with metformin can significantly inhibit the GC level,increase the ADP level,decrease the incidence rate of hypoglycemia,and does not affect the body weight of patients.
2018, 43(11): 1471-1473.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.022
Abstract:
Objective: To explore the prognostic value of the serum levels of procalcitonin(PCT),platelet(PLT) and D-dimer in patients with sepsis.Methods: Forty-five patients with sepsis were divided into the non-septic shock group(25 cases) and septic shock group(20 cases),and 25 patients without sepsis were set as the control group.The levels of PCT,PLT and D-dimer in three groups were detected within 24 to 48 h of admission,and analyzed.Results: The levels of PCT and D-dimer in sepsis group were higher than those in control group,and the PLT level in sepsis group was lower than that in control group,and the difference of which was statistically significant(P<0.01).The levels of PCT and D-dimer in septic shock group were higher than those in non-septic shock group,and the PLT level in septic shock group was lower than that in non-septic shock group,and the difference of which was statistically significant(P<0.01).The three indexes in sepsis group were significantly correlated with prognosis,the PCT and D-dimer levels in patients with good prognosis were lower than those in patients with poor prognosis,and the PLT levelsin patients with good prognosis were higher than those in patients with poor prognosis(P<0.01).Correlation analysis showed the PCT level was significantly positively correlated with the scores of SOFA and APACHEⅡ,and the PLT level was significantly negatively correlated with the scores of SOFA and APACHEⅡ in sepsis group.Conclusions: The levels of PCT,PLT and D-dimer can be used as the predictors of evaluating the severity and prognosis of sepsis.
Objective: To explore the prognostic value of the serum levels of procalcitonin(PCT),platelet(PLT) and D-dimer in patients with sepsis.Methods: Forty-five patients with sepsis were divided into the non-septic shock group(25 cases) and septic shock group(20 cases),and 25 patients without sepsis were set as the control group.The levels of PCT,PLT and D-dimer in three groups were detected within 24 to 48 h of admission,and analyzed.Results: The levels of PCT and D-dimer in sepsis group were higher than those in control group,and the PLT level in sepsis group was lower than that in control group,and the difference of which was statistically significant(P<0.01).The levels of PCT and D-dimer in septic shock group were higher than those in non-septic shock group,and the PLT level in septic shock group was lower than that in non-septic shock group,and the difference of which was statistically significant(P<0.01).The three indexes in sepsis group were significantly correlated with prognosis,the PCT and D-dimer levels in patients with good prognosis were lower than those in patients with poor prognosis,and the PLT levelsin patients with good prognosis were higher than those in patients with poor prognosis(P<0.01).Correlation analysis showed the PCT level was significantly positively correlated with the scores of SOFA and APACHEⅡ,and the PLT level was significantly negatively correlated with the scores of SOFA and APACHEⅡ in sepsis group.Conclusions: The levels of PCT,PLT and D-dimer can be used as the predictors of evaluating the severity and prognosis of sepsis.
2018, 43(11): 1474-1477.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.023
Abstract:
Objective: To investigate the anesthetic effects of femoral nerve combined with sciatic nerve block guided by ultrasound in the great saphenous vein stripping in anticoagulation patients.Methods: Forty anticoagulant patients treated with unilateral great saphenous vein stripping were divided into the observation group and control group according to the random number table method(20 cases each group).The observation group was treated with the femoral nerve combined with sciatic nerve block anesthesia guided by ultrasound,and the control group was treated with spinal anesthesia.The changes of blood pressure and heart rate(HR) in two groups were observed before and after anesthesia block,the onset time and operation time of anesthesia in two groups were recorded,and the anesthetic effect,postoperative pain degree and adverse reactions between two groups were compared.Results: The differences of SBP,DBP and HR in observation group between before and after anesthesia block were not statistically significant(P>0.05).In control group,the SBP and DBP at T2 were significantly lower than those at T0 and T1(P<0.01),and the SBP and DBP at T3 were significantly higher than those at T2(P<0.01).The SBP and DBP in observation group at T2 were significantly higher than those in control group at the same time-point(P<0.01).The intraoperative infusion volume in observation group was significantly lower than that in control group(P<0.01).The difference of the usage rate of intraoperative antihypertensive drug between two groups was not statistically significant(P>0.05).The anesthesia effect in observation group was significantly better than that in control group(P<0.05).The incidence rate of postoperative complications in observation group was lower than that in control group(P<0.05).Conclusions: The application of femoral nerve combined with sciatic nerve block guided by ultrasound in the great saphenous vein stripping in anticoagulation patients has good anesthetic effects,can stabilize the intraoperative blood pressure,has low infusion volume,low postoperative pain degree and little adverse reaction,which is worthy of clinical application.
Objective: To investigate the anesthetic effects of femoral nerve combined with sciatic nerve block guided by ultrasound in the great saphenous vein stripping in anticoagulation patients.Methods: Forty anticoagulant patients treated with unilateral great saphenous vein stripping were divided into the observation group and control group according to the random number table method(20 cases each group).The observation group was treated with the femoral nerve combined with sciatic nerve block anesthesia guided by ultrasound,and the control group was treated with spinal anesthesia.The changes of blood pressure and heart rate(HR) in two groups were observed before and after anesthesia block,the onset time and operation time of anesthesia in two groups were recorded,and the anesthetic effect,postoperative pain degree and adverse reactions between two groups were compared.Results: The differences of SBP,DBP and HR in observation group between before and after anesthesia block were not statistically significant(P>0.05).In control group,the SBP and DBP at T2 were significantly lower than those at T0 and T1(P<0.01),and the SBP and DBP at T3 were significantly higher than those at T2(P<0.01).The SBP and DBP in observation group at T2 were significantly higher than those in control group at the same time-point(P<0.01).The intraoperative infusion volume in observation group was significantly lower than that in control group(P<0.01).The difference of the usage rate of intraoperative antihypertensive drug between two groups was not statistically significant(P>0.05).The anesthesia effect in observation group was significantly better than that in control group(P<0.05).The incidence rate of postoperative complications in observation group was lower than that in control group(P<0.05).Conclusions: The application of femoral nerve combined with sciatic nerve block guided by ultrasound in the great saphenous vein stripping in anticoagulation patients has good anesthetic effects,can stabilize the intraoperative blood pressure,has low infusion volume,low postoperative pain degree and little adverse reaction,which is worthy of clinical application.
2018, 43(11): 1478-1480.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.024
Abstract:
Objective: To analyze the application value of total intravenous combined with sevoflurane laryngeal mask inhalation anesthesia in laparoscopic assisted vaginal hysterectomy.Methods: One hundred patients scheduled by vaginal hysterectomy were divided into the control group(n=47) and observation group(n=53).The control group and observation group were anesthetized using total intravenous method,and total intravenous combined with sevoflurane laryngeal mask inhalation method,respectively.The mean arterial pressure,heart rate,postoperative recovery time,anesthetic initiation time,and postoperative pain and administration time between two groups were compared.Results: The differences of the mean arterial pressure and heart rate between two groups at T1 and T2 were not statistically significant(P>0.05).After T3,the mean arterial pressure and heart rate in observation group were significantly higher than those in control group(P<0.01).The postoperative awakening time and onset time of anesthesia in observation group were significantly shorter than those in control group(P<0.01),and the postoperative pain time and administration time in observation group was significantly higher than those in control group(P<0.01).Conclusions: The application of total intravenous combined with sevoflurane laryngeal mask inhalation anesthesia in laparoscopic assisted vaginal hysterectomy can effectively shorten the onset time of anesthesia and postoperative awakening time,which has better clinical effect.
Objective: To analyze the application value of total intravenous combined with sevoflurane laryngeal mask inhalation anesthesia in laparoscopic assisted vaginal hysterectomy.Methods: One hundred patients scheduled by vaginal hysterectomy were divided into the control group(n=47) and observation group(n=53).The control group and observation group were anesthetized using total intravenous method,and total intravenous combined with sevoflurane laryngeal mask inhalation method,respectively.The mean arterial pressure,heart rate,postoperative recovery time,anesthetic initiation time,and postoperative pain and administration time between two groups were compared.Results: The differences of the mean arterial pressure and heart rate between two groups at T1 and T2 were not statistically significant(P>0.05).After T3,the mean arterial pressure and heart rate in observation group were significantly higher than those in control group(P<0.01).The postoperative awakening time and onset time of anesthesia in observation group were significantly shorter than those in control group(P<0.01),and the postoperative pain time and administration time in observation group was significantly higher than those in control group(P<0.01).Conclusions: The application of total intravenous combined with sevoflurane laryngeal mask inhalation anesthesia in laparoscopic assisted vaginal hysterectomy can effectively shorten the onset time of anesthesia and postoperative awakening time,which has better clinical effect.
2018, 43(11): 1481-1483.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.025
Abstract:
Objective: To explore the pathogens distribution and risk factors of incision infection in elderly patients after spinal surgery.Methods: The clinical data of 569 elderly patients treated with spinal surgery were retrospectively analyzed.The distribution of pathogens in infection incision was analyzed.The risk factors of incision infection in elderly patients after spinal surgery were analyzed using the univariate and multivariate logistic regression analysis.Results: Among 569 elderly patients treated with spinal surgery,24 patients were infected,and the infection rate was 4.22%.Thirty-one pathogens were found,which included 21 strains(67.74%) of gram-negative bacteria,9 strains(29.03%) of gram-positive bacteria,and 1 strain(3.23%) of fungi.The univariate analysis showed that the malnutrition,BMI ≥ 28 kg/m2,operative time ≥ 150 min,invasive procedures,internal fixation devices and diabetes were the risk factors of spinal surgical incision infection(P<0.05 to P<0.01).The multivariate logistic regression analysis showed that the BMI ≥ 28 kg/m2,operation time ≥ 150 min and diabetes were the independent risk factors of spinal surgical incision infection in elderly patients(P<0.05 to P<0.01).Conclusions: The pathogen of incision infection of spinal surgery is wide in elderly patients,and the risk factors associated with postoperative infection is various.The targeted measures and rational antimicrobial agents should be used to reduce the infection rate.
Objective: To explore the pathogens distribution and risk factors of incision infection in elderly patients after spinal surgery.Methods: The clinical data of 569 elderly patients treated with spinal surgery were retrospectively analyzed.The distribution of pathogens in infection incision was analyzed.The risk factors of incision infection in elderly patients after spinal surgery were analyzed using the univariate and multivariate logistic regression analysis.Results: Among 569 elderly patients treated with spinal surgery,24 patients were infected,and the infection rate was 4.22%.Thirty-one pathogens were found,which included 21 strains(67.74%) of gram-negative bacteria,9 strains(29.03%) of gram-positive bacteria,and 1 strain(3.23%) of fungi.The univariate analysis showed that the malnutrition,BMI ≥ 28 kg/m2,operative time ≥ 150 min,invasive procedures,internal fixation devices and diabetes were the risk factors of spinal surgical incision infection(P<0.05 to P<0.01).The multivariate logistic regression analysis showed that the BMI ≥ 28 kg/m2,operation time ≥ 150 min and diabetes were the independent risk factors of spinal surgical incision infection in elderly patients(P<0.05 to P<0.01).Conclusions: The pathogen of incision infection of spinal surgery is wide in elderly patients,and the risk factors associated with postoperative infection is various.The targeted measures and rational antimicrobial agents should be used to reduce the infection rate.
2018, 43(11): 1486-1488,1492.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.027
Abstract:
Objective: To investigate the self-rating status of girls in pubertal Tanner stage from grade 4-6 in primary schools and grade 1-3 in junior high schools,and its correlation with relative pubertal timing.Methods: A total of 1 113 girls from grade 4 to grade 9 of five schools in Bengbu city were sampled using stratified random cluster sampling,and investigated using the pubertal Tanner stage assessment and relative pubertal timing questionnaire.Results: Among the each indicator of pubertal Tanner stage,the median ages of breast Tanner Ⅱ、Ⅲ、Ⅳ stage were 9.71,12.06 and 15.03 years old,respectively,and the median ages of pubic hair Tanner Ⅱ、Ⅲ、Ⅳ stage were 10.99,12.39 and 14.98 years old,respectively.The median age of menarche was 11.71 years old.There was a significantly positive correlation between each indicator of relative pubertal timing and pubertal Tanner stage assessment(including breast,pubic hair and menstruation)(P<0.01).Conclusions: The order of onset of puberty during Tanner's developmental stage is breast development,then pubic hair development,and finally menarche,and the self-rating of pubertal Tanner stage is consistent with relative pubertal timing.
Objective: To investigate the self-rating status of girls in pubertal Tanner stage from grade 4-6 in primary schools and grade 1-3 in junior high schools,and its correlation with relative pubertal timing.Methods: A total of 1 113 girls from grade 4 to grade 9 of five schools in Bengbu city were sampled using stratified random cluster sampling,and investigated using the pubertal Tanner stage assessment and relative pubertal timing questionnaire.Results: Among the each indicator of pubertal Tanner stage,the median ages of breast Tanner Ⅱ、Ⅲ、Ⅳ stage were 9.71,12.06 and 15.03 years old,respectively,and the median ages of pubic hair Tanner Ⅱ、Ⅲ、Ⅳ stage were 10.99,12.39 and 14.98 years old,respectively.The median age of menarche was 11.71 years old.There was a significantly positive correlation between each indicator of relative pubertal timing and pubertal Tanner stage assessment(including breast,pubic hair and menstruation)(P<0.01).Conclusions: The order of onset of puberty during Tanner's developmental stage is breast development,then pubic hair development,and finally menarche,and the self-rating of pubertal Tanner stage is consistent with relative pubertal timing.
2018, 43(11): 1489-1492.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.028
Abstract:
Objective: To investigate the AIDS-related knowledge,attitude,behavior and interventions among normal university and medical college freshmen,and provide the scientific evidence for preventing and treating AIDS among this two kinds of university.Methods: One thousand three hundred and sixty-four freshmen from normal university and medical college freshmen were investigated using self-compiled questionnaire.Results: In terms of HIV awareness,the correct rate of 8 AIDS knowledge problems in medical college freshmen(6 items correct) was higher than that in normal university freshmen(P<0.01),and the difference of the correct rate of two problems between two schools was not statistically significant(P>0.05).The discrimination rate of normal university freshmen to family member with AIDS(48.32%) was higher than that in medical college freshmen(31.42%)(P<0.01).The difference of the incidence rate of sexual behavior between medical college freshmen(4.55%) and normal university freshmen(4.84%) was not statistically significant(P>0.05).The unsafe sexual behavior was found in freshmen.The AIDS-related prevention knowledge was advertised in 46.85% normal university freshmen and 40.09% medical college freshmen at recent year.Conclusions: Basing on different mastery of AIDS knowledge between normal university and medical college,the systematic and professional AIDS health education activities should be pertinently carried out to promote the healthy development of students and long-term development of AIDS prevention and treatment.
Objective: To investigate the AIDS-related knowledge,attitude,behavior and interventions among normal university and medical college freshmen,and provide the scientific evidence for preventing and treating AIDS among this two kinds of university.Methods: One thousand three hundred and sixty-four freshmen from normal university and medical college freshmen were investigated using self-compiled questionnaire.Results: In terms of HIV awareness,the correct rate of 8 AIDS knowledge problems in medical college freshmen(6 items correct) was higher than that in normal university freshmen(P<0.01),and the difference of the correct rate of two problems between two schools was not statistically significant(P>0.05).The discrimination rate of normal university freshmen to family member with AIDS(48.32%) was higher than that in medical college freshmen(31.42%)(P<0.01).The difference of the incidence rate of sexual behavior between medical college freshmen(4.55%) and normal university freshmen(4.84%) was not statistically significant(P>0.05).The unsafe sexual behavior was found in freshmen.The AIDS-related prevention knowledge was advertised in 46.85% normal university freshmen and 40.09% medical college freshmen at recent year.Conclusions: Basing on different mastery of AIDS knowledge between normal university and medical college,the systematic and professional AIDS health education activities should be pertinently carried out to promote the healthy development of students and long-term development of AIDS prevention and treatment.
2018, 43(11): 1493-1495.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.029
Abstract:
Objective: To explore the clinical application value of multi-slice spiral CT(MSCT) in the diagnosis of occult minor fractures.Methods: One hundred and eighty-one patients with occult fractures were examined by X-ray,CR,conventional CT and multi-slice spiral CT,respectively.The detection rate of occult fractures among four methods were compared.Results: Among 181 patients,there were 46 cases of limbs fracture,52 cases of rib fracture,30 cases of pelvic fracture,25 cases of femoral neck fractures,and 28 cases of facial fractures.The differences of the detection and total detect rate of all type fractures were statistical significance(P<0.01),the highest of which was MSCT,followed by CT,CR and X-ray(P<0.05).The differences of the detection and total detect rate of different 3D reconstruction techniques of MSCT were statistical significance(P<0.01),and the total detect rates of MPR,SSD,VR and MIP were 100.00%,83.98%,66.30% and 31.49%,respectively(P<0.05).Conclusions: The application value of three-dimensional reconstruction technique of multi-slice spiral CT in the diagnosis of occult minor fracture is better than that of X-ray,CR and conventional CT.The effect of MPR reconstruction technology is the best,which is worthy of promotion in clinic.
Objective: To explore the clinical application value of multi-slice spiral CT(MSCT) in the diagnosis of occult minor fractures.Methods: One hundred and eighty-one patients with occult fractures were examined by X-ray,CR,conventional CT and multi-slice spiral CT,respectively.The detection rate of occult fractures among four methods were compared.Results: Among 181 patients,there were 46 cases of limbs fracture,52 cases of rib fracture,30 cases of pelvic fracture,25 cases of femoral neck fractures,and 28 cases of facial fractures.The differences of the detection and total detect rate of all type fractures were statistical significance(P<0.01),the highest of which was MSCT,followed by CT,CR and X-ray(P<0.05).The differences of the detection and total detect rate of different 3D reconstruction techniques of MSCT were statistical significance(P<0.01),and the total detect rates of MPR,SSD,VR and MIP were 100.00%,83.98%,66.30% and 31.49%,respectively(P<0.05).Conclusions: The application value of three-dimensional reconstruction technique of multi-slice spiral CT in the diagnosis of occult minor fracture is better than that of X-ray,CR and conventional CT.The effect of MPR reconstruction technology is the best,which is worthy of promotion in clinic.
2018, 43(11): 1496-1498.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.030
Abstract:
Objective: To assess the diagnostic value of digital breast tomosynthesis(DBT) combined with full field digital mammography(FFDM) in breast cancer.Methods: The imaging data of FFDM and DBT in 70 patients with breast cancer were retrospectively analyzed.The imaging results of the routine FFDM(craniocaudal position and mediolateral oblique position) were compared with the imaging results of FFDM combined with DBT.The lesions presentation,edge detail and peripheral sign in two groups were recorded,and the lesion was evaluated by mammographic report and BI-RADS.Results: The malignant lesions in 46 cases and bengin lesions in 24 cases were diagnosed using the routine FFDM imaging,and the coincidence rate of which in accordance with the results of pathology was 66%.The malignant lesions in 57 cases and bengin lesions in 13 cases were about diagnosed using the joint examination,and the coincidence rate of which in accordan-ce with the results of pathology was about 81%.The evaluation difference between two methods was statistically significant(P<0.05).Conclusions: DBT can improve the display and diagnosis efficiency of breast lesions,and early diagnosis level of breast cancer,which has good clinical significance.
Objective: To assess the diagnostic value of digital breast tomosynthesis(DBT) combined with full field digital mammography(FFDM) in breast cancer.Methods: The imaging data of FFDM and DBT in 70 patients with breast cancer were retrospectively analyzed.The imaging results of the routine FFDM(craniocaudal position and mediolateral oblique position) were compared with the imaging results of FFDM combined with DBT.The lesions presentation,edge detail and peripheral sign in two groups were recorded,and the lesion was evaluated by mammographic report and BI-RADS.Results: The malignant lesions in 46 cases and bengin lesions in 24 cases were diagnosed using the routine FFDM imaging,and the coincidence rate of which in accordance with the results of pathology was 66%.The malignant lesions in 57 cases and bengin lesions in 13 cases were about diagnosed using the joint examination,and the coincidence rate of which in accordan-ce with the results of pathology was about 81%.The evaluation difference between two methods was statistically significant(P<0.05).Conclusions: DBT can improve the display and diagnosis efficiency of breast lesions,and early diagnosis level of breast cancer,which has good clinical significance.
2018, 43(11): 1499-1500,1504.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.031
Abstract:
Objective: To investigate the changes of serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ,and its ratio in patients with primary hypertension.Methods: The serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ of fasting venous blood in 107 patients with primary hypertension were detected using enzyme-linked immunosorbent assay,and the difference of which between two groups was compared.Results: The serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ in patients with primary hypertension were significantly higher than those in control group(P<0.01).The difference of the ratio of pepsinogen Ⅰ and pepsinogen Ⅱ between two groups was not statistically significant(P<0.05).Conclusions: The serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ in patients with primary hypertension significantly increase,which may be related to the primary hypertension under excluding stomach diseases.
Objective: To investigate the changes of serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ,and its ratio in patients with primary hypertension.Methods: The serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ of fasting venous blood in 107 patients with primary hypertension were detected using enzyme-linked immunosorbent assay,and the difference of which between two groups was compared.Results: The serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ in patients with primary hypertension were significantly higher than those in control group(P<0.01).The difference of the ratio of pepsinogen Ⅰ and pepsinogen Ⅱ between two groups was not statistically significant(P<0.05).Conclusions: The serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ in patients with primary hypertension significantly increase,which may be related to the primary hypertension under excluding stomach diseases.
2018, 43(11): 1501-1504.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.032
Abstract:
Objective: To investigate the predict value of the mean platelet volume(MPV) on prognosis of the ischemic stroke patients treated with recombinant tissue type plasminogen activator(rtPA) intravenous thrombolysis.Methods: The prognosis of patients treated with rtPA thrombolysis was evaluated using the modified Rankin scale(MRS).The patients were divided into the good prognosis group and poor prognosis group,and the influence of MPV on the prognosis of patients treated with rtPA thrombolysis was discussed.Results: The differences of the age,incidence rate of atrial fibrillation,aspirin use history,systolic blood pressure,diastolic blood pressure,NIHSS score,INR,blood glucose,total cholesterol,high-density lipoprotein cholesterol,low density lipoprotein cholesterol,thrombocytocrit,MPV,platelet distribution width and CISS typing between two groups were statistically significant(P<0.05 to P<0.01).Logistic regression analysis showed that the age,previous aspirin use history,baseline NIHSS score,blood glucose,LDL-C,MPV,PDW,cardiogenic stroke and perforating artery disease were the independent influencing factors of the prognosis of rtPA thrombolytic therapy(P<0.05 to P<0.01).Linear regression analysis showed that the MPV was negatively correlated with MRS score(P<0.05).The best clinic point of MPV in the diagnosis of the prognosis of rtPA thrombolytic therapy was 10.12 fL,and the sensitivity,specificity,AUC,negative predictive value,positive predictive value and accuracy of MPV were 89.2%,87.8%,0.882,84.6%,91.5% and 88.4%,respectively.Conclusions: MPV has a certain predictive value in rtPA thrombolysis treating acute ischemic stroke,which is an independent risk factor of short-term thrombolysis treatment.
Objective: To investigate the predict value of the mean platelet volume(MPV) on prognosis of the ischemic stroke patients treated with recombinant tissue type plasminogen activator(rtPA) intravenous thrombolysis.Methods: The prognosis of patients treated with rtPA thrombolysis was evaluated using the modified Rankin scale(MRS).The patients were divided into the good prognosis group and poor prognosis group,and the influence of MPV on the prognosis of patients treated with rtPA thrombolysis was discussed.Results: The differences of the age,incidence rate of atrial fibrillation,aspirin use history,systolic blood pressure,diastolic blood pressure,NIHSS score,INR,blood glucose,total cholesterol,high-density lipoprotein cholesterol,low density lipoprotein cholesterol,thrombocytocrit,MPV,platelet distribution width and CISS typing between two groups were statistically significant(P<0.05 to P<0.01).Logistic regression analysis showed that the age,previous aspirin use history,baseline NIHSS score,blood glucose,LDL-C,MPV,PDW,cardiogenic stroke and perforating artery disease were the independent influencing factors of the prognosis of rtPA thrombolytic therapy(P<0.05 to P<0.01).Linear regression analysis showed that the MPV was negatively correlated with MRS score(P<0.05).The best clinic point of MPV in the diagnosis of the prognosis of rtPA thrombolytic therapy was 10.12 fL,and the sensitivity,specificity,AUC,negative predictive value,positive predictive value and accuracy of MPV were 89.2%,87.8%,0.882,84.6%,91.5% and 88.4%,respectively.Conclusions: MPV has a certain predictive value in rtPA thrombolysis treating acute ischemic stroke,which is an independent risk factor of short-term thrombolysis treatment.
2018, 43(11): 1505-1509.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.033
Abstract:
Objective: To know the turnover intention of registered nurses in top-three hospitals of Anhui,and analyze the relationships between work-family conflict,occupational commitment and turnover intention for providing the basis in decreasing the turnover rate of nurses and stabilizing the nurse team.Methods: A total of 880 registered nurses were investigated using the work-family conflict scale,competency inventory for registered nurse scale and turnover intention scale.Results: The result of single factor analysis showed that the turnover intention of registered nurses in top-three hospitals was lower than that in grade two hospitals(P<0.01),the score of which in common nurse was higher than that in head nurse(P<0.01),and the scores of which in personnel agent and contract nurses were higher than that in formal nurse(P<0.01).The lower the professional title,the higher the dissatisfaction,the worse the health condition and the lower the professional interest and income,the higher the turnover intention score was(P<0.01).The turnover intention scores in department of pediatrics and emergency medicine were higher than that in other departments(P<0.01).The total scores of work-family conflict and each dimension were positively related to the turnover intention(P<0.01).The total scores of occupational commitment and each dimension were negatively related to the turnover intention(P<0.01).Multivariate analysis showed that the opportunity commitment,family-work conflict,normative commitment,emotional commitment,professional interest,hospital type and annual income were the influencing factors in turn,and the influencing rate of those was is 59.0%(R2=0.590,P<0.01).Conclusions: The nursing managers should take intervention measures to decrease the family-work conflict,and improve occupational commitment for reducing the turnover rate and stabilizing nursing team.
Objective: To know the turnover intention of registered nurses in top-three hospitals of Anhui,and analyze the relationships between work-family conflict,occupational commitment and turnover intention for providing the basis in decreasing the turnover rate of nurses and stabilizing the nurse team.Methods: A total of 880 registered nurses were investigated using the work-family conflict scale,competency inventory for registered nurse scale and turnover intention scale.Results: The result of single factor analysis showed that the turnover intention of registered nurses in top-three hospitals was lower than that in grade two hospitals(P<0.01),the score of which in common nurse was higher than that in head nurse(P<0.01),and the scores of which in personnel agent and contract nurses were higher than that in formal nurse(P<0.01).The lower the professional title,the higher the dissatisfaction,the worse the health condition and the lower the professional interest and income,the higher the turnover intention score was(P<0.01).The turnover intention scores in department of pediatrics and emergency medicine were higher than that in other departments(P<0.01).The total scores of work-family conflict and each dimension were positively related to the turnover intention(P<0.01).The total scores of occupational commitment and each dimension were negatively related to the turnover intention(P<0.01).Multivariate analysis showed that the opportunity commitment,family-work conflict,normative commitment,emotional commitment,professional interest,hospital type and annual income were the influencing factors in turn,and the influencing rate of those was is 59.0%(R2=0.590,P<0.01).Conclusions: The nursing managers should take intervention measures to decrease the family-work conflict,and improve occupational commitment for reducing the turnover rate and stabilizing nursing team.
2018, 43(11): 1510-1513.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.034
Abstract:
Objective: To explore the application effects of continuous within hospital-out of hospital dual care programme in patients treated with coronary intervention.Methods: Eighty-six patients with coronary heart disease were randomly divided into the observation group and control group(43 cases each group).The control group was nursed with routine method,and the observation group was additionally nursed with continuous within hospital-out of hospital dual care programme based on the routine nursing.The cognitive level and risk factor control evaluation in two groups were investigated using questionnaire at admission,and after 1 and 3 months of discharge.The incidence rate of adverse events between two groups was compared.Results: The differences of the scores of rehabilitation knowledge and prevention behavior between two groups at admission were not statistically significant(P>0.05).The scores of rehabilitation knowledge and prevention behavior in observation group were significantly higher than those in control group after 1 and 3 months of discharge(P<0.01).The differences of the BP,LDL-C,FBG,smoking cessation and sport motion control rate between two groups at admission were not statistically significant(P>0.05).The levels of BP,LDL-C,FBG,smoking cessation and motion control rate in observation group were significantly higher than those in control group after 1 and 3 months of discharge(P<0.01).The incidence rates of acute myocardial infarction and unstable angina in observation group were significantly lower than those in control group(P<0.01).Conclusions: The continuous within hospital-out of hospital dual care programme can improve the cognitive level of disease,control bad behaviour,and reduce the incidence rate of adverse event in patients treated with coronary intervention,which is worthy of promotion in clinic.
Objective: To explore the application effects of continuous within hospital-out of hospital dual care programme in patients treated with coronary intervention.Methods: Eighty-six patients with coronary heart disease were randomly divided into the observation group and control group(43 cases each group).The control group was nursed with routine method,and the observation group was additionally nursed with continuous within hospital-out of hospital dual care programme based on the routine nursing.The cognitive level and risk factor control evaluation in two groups were investigated using questionnaire at admission,and after 1 and 3 months of discharge.The incidence rate of adverse events between two groups was compared.Results: The differences of the scores of rehabilitation knowledge and prevention behavior between two groups at admission were not statistically significant(P>0.05).The scores of rehabilitation knowledge and prevention behavior in observation group were significantly higher than those in control group after 1 and 3 months of discharge(P<0.01).The differences of the BP,LDL-C,FBG,smoking cessation and sport motion control rate between two groups at admission were not statistically significant(P>0.05).The levels of BP,LDL-C,FBG,smoking cessation and motion control rate in observation group were significantly higher than those in control group after 1 and 3 months of discharge(P<0.01).The incidence rates of acute myocardial infarction and unstable angina in observation group were significantly lower than those in control group(P<0.01).Conclusions: The continuous within hospital-out of hospital dual care programme can improve the cognitive level of disease,control bad behaviour,and reduce the incidence rate of adverse event in patients treated with coronary intervention,which is worthy of promotion in clinic.
2018, 43(11): 1514-1517,1522.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.035
Abstract:
Objective: To investigate the effects of the comprehensive stage nursing intervention combined with rabbit skin extract inflamed by vaccinia virus and lappaconitine adhesive patch on the clinical outcomes of patients with traumatic lower limb amputation.Methods: One hundred and eighty patients with traumatic lower limb amputation were divided into the comprehensive stage nursing intervention combined with rabbit skin extract inflamed by vaccinia virus and lappaconitine adhesive patch therapy group(90 cases,observation group) and routine nursing intervention combined with rabbit skin extract inflamed by vaccinia virus and lappaconitine adhesive patch therapy group(90 cases,control group) according to the random number table method.The clinical and damage data of all patients on admission were obtained.After 30 d of operation,the differences of McGill SF-MPQ score,SCL-90 score,SF-36 score and incidence rate of complications between two groups were compared.Results: After 30 d of operation,the scores of PRI,VAS,PPI and SCL-90 in observation group were significantly lower than those in control group(P<0.05 to P<0.01).After 30 d of operation,the scores of mental health,vitality,somatic pain,social function and emotional function of SF-36 scale in observation group were higher than those in control group(P<0.01).The difference of the incidence rate of complications between the observation group(8.89%) and control group(13.33%) was not statistically significant(P>0.05).Conclusions: Compared with the routine nursing intervention,the comprehensive stage nursing intervention combined with rabbit skin extract inflamed by vaccinia virus and lappaconitine adhesive patch therapy is more conducive to improve the short-term clinical outcome of patients with traumatic lower limb amputation.
Objective: To investigate the effects of the comprehensive stage nursing intervention combined with rabbit skin extract inflamed by vaccinia virus and lappaconitine adhesive patch on the clinical outcomes of patients with traumatic lower limb amputation.Methods: One hundred and eighty patients with traumatic lower limb amputation were divided into the comprehensive stage nursing intervention combined with rabbit skin extract inflamed by vaccinia virus and lappaconitine adhesive patch therapy group(90 cases,observation group) and routine nursing intervention combined with rabbit skin extract inflamed by vaccinia virus and lappaconitine adhesive patch therapy group(90 cases,control group) according to the random number table method.The clinical and damage data of all patients on admission were obtained.After 30 d of operation,the differences of McGill SF-MPQ score,SCL-90 score,SF-36 score and incidence rate of complications between two groups were compared.Results: After 30 d of operation,the scores of PRI,VAS,PPI and SCL-90 in observation group were significantly lower than those in control group(P<0.05 to P<0.01).After 30 d of operation,the scores of mental health,vitality,somatic pain,social function and emotional function of SF-36 scale in observation group were higher than those in control group(P<0.01).The difference of the incidence rate of complications between the observation group(8.89%) and control group(13.33%) was not statistically significant(P>0.05).Conclusions: Compared with the routine nursing intervention,the comprehensive stage nursing intervention combined with rabbit skin extract inflamed by vaccinia virus and lappaconitine adhesive patch therapy is more conducive to improve the short-term clinical outcome of patients with traumatic lower limb amputation.
2018, 43(11): 1518-1522.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.036
Abstract:
Objective: To study the relationship between the presenteeism behavior and work performance of operating room nurses in grade A tertiary hospitals.Methods: Two hundred and sixteen operating room nurses from 3 grade A tertiary hospitals were selected using the cluster sampling method,and investigated using the "presenteeism behavior questionnaire" and "job performance scale".Results: The scores of presenteeism behavior and job performance were(4.43±1.64) and(74.28±7.29),respectively.The presenteeism behavior score of contract nurses was higher than that of enrolled nurses(P<0.01),the presenteeism behavior score of nursing managers was higher than that of general nurses(P<0.05),and the presenteeism behavior score of nurses with bachelor degree or above was higher than that of nurses with college degree nurses(P<0.05).The scores of job performance and its each dimension of enrolled nurses were higher those of contract nurses(P<0.05 to P<0.01),and the score of job performance dimension of nurse practitioner,nurse-in-charge and above title nurses were higher that of general nurses(P<0.05).The presenteeism behavior in operating room nurses was negatively correlated with work performance and its dimension(P<0.01).Structural equation model showd that the presenteeism behavior performance had a direct negative effect on work,the standardized path coefficient was -0.561(P<0.01),and the "presenteeism" variables could explain the 31% "performance" of the variance.Conclusions: The job performance of operating room nurses in grade A tertiary hospitals is higher,and the presenteeism behavior situation is not optimistic.The presenteeism behavior has certain prediction effect on job performance.Nursing managers should focus on reducing the presenteeism behavior of operating room nurses,and further improve the nurses' job performance.
Objective: To study the relationship between the presenteeism behavior and work performance of operating room nurses in grade A tertiary hospitals.Methods: Two hundred and sixteen operating room nurses from 3 grade A tertiary hospitals were selected using the cluster sampling method,and investigated using the "presenteeism behavior questionnaire" and "job performance scale".Results: The scores of presenteeism behavior and job performance were(4.43±1.64) and(74.28±7.29),respectively.The presenteeism behavior score of contract nurses was higher than that of enrolled nurses(P<0.01),the presenteeism behavior score of nursing managers was higher than that of general nurses(P<0.05),and the presenteeism behavior score of nurses with bachelor degree or above was higher than that of nurses with college degree nurses(P<0.05).The scores of job performance and its each dimension of enrolled nurses were higher those of contract nurses(P<0.05 to P<0.01),and the score of job performance dimension of nurse practitioner,nurse-in-charge and above title nurses were higher that of general nurses(P<0.05).The presenteeism behavior in operating room nurses was negatively correlated with work performance and its dimension(P<0.01).Structural equation model showd that the presenteeism behavior performance had a direct negative effect on work,the standardized path coefficient was -0.561(P<0.01),and the "presenteeism" variables could explain the 31% "performance" of the variance.Conclusions: The job performance of operating room nurses in grade A tertiary hospitals is higher,and the presenteeism behavior situation is not optimistic.The presenteeism behavior has certain prediction effect on job performance.Nursing managers should focus on reducing the presenteeism behavior of operating room nurses,and further improve the nurses' job performance.
2018, 43(11): 1523-1527.
doi: 10.13898/j.cnki.issn.1000-2200.2018.11.037
Abstract:
Objective: To investigate the effects of oral cavity nursing intervention based on the dietary guidance on the compliance behavior in patients with dental ulcer.Methods: One hundred patients with dental ulcer were divided into the observation group and control group according to the random number table method(50 cases each group).The control group was intervened using conventional oral nursing,and the observation group was intervened using oral cavity nursing intervention based on the dietary guidance on the basis of control group.The compliance behavior in two groups was evaluated using the modified Morisky adherence questionnaire(MMAS-8),the pain degree in two groups was assessed using the visual analogue scale(VAS),the knowledge of dental ulcer and diet in two groups was evaluated using the self-made questionnaire,and the risk factors of influencing the ulcer healing in two groups were analyzed.Results: The mastery rates of the disease and diet knowledge in observation group were significantly higher than that in control group(P<0.01).After 1,4 and 7 d of intervention,the VAS scores and MMAS-8 scores in observation group were significantly lower and higher than those in control group,respectively(P<0.01).After intervention,the feeding compliance rate of all kinds of food in observation group was higher than that in control group(P<0.05 to P<0.01),the excellent rate of mouth healing in observation group was higher than that in control group(P<0.05),and the healing time in observation group was significantly shorter than that in control group(P<0.01).Logistic regression analysis results showed that the unknowledge of disease and diet,degree of pain,poor compliance behavior and underfeeding were the independent risk factors of the poor healing(P<0.01).Conclusions: The oral cavity nursing intervention based on the dietary guidance can effectively improve the compliance behavior and healing effect,and alleviate the pain of patients,which is worthy of promotion in clinic.
Objective: To investigate the effects of oral cavity nursing intervention based on the dietary guidance on the compliance behavior in patients with dental ulcer.Methods: One hundred patients with dental ulcer were divided into the observation group and control group according to the random number table method(50 cases each group).The control group was intervened using conventional oral nursing,and the observation group was intervened using oral cavity nursing intervention based on the dietary guidance on the basis of control group.The compliance behavior in two groups was evaluated using the modified Morisky adherence questionnaire(MMAS-8),the pain degree in two groups was assessed using the visual analogue scale(VAS),the knowledge of dental ulcer and diet in two groups was evaluated using the self-made questionnaire,and the risk factors of influencing the ulcer healing in two groups were analyzed.Results: The mastery rates of the disease and diet knowledge in observation group were significantly higher than that in control group(P<0.01).After 1,4 and 7 d of intervention,the VAS scores and MMAS-8 scores in observation group were significantly lower and higher than those in control group,respectively(P<0.01).After intervention,the feeding compliance rate of all kinds of food in observation group was higher than that in control group(P<0.05 to P<0.01),the excellent rate of mouth healing in observation group was higher than that in control group(P<0.05),and the healing time in observation group was significantly shorter than that in control group(P<0.01).Logistic regression analysis results showed that the unknowledge of disease and diet,degree of pain,poor compliance behavior and underfeeding were the independent risk factors of the poor healing(P<0.01).Conclusions: The oral cavity nursing intervention based on the dietary guidance can effectively improve the compliance behavior and healing effect,and alleviate the pain of patients,which is worthy of promotion in clinic.
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