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2018 Vol. 43, No. 12
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2018, 43(12): 1541-1545.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.001
Abstract:
Objective:To investigate the effect of monocarboxylate transporter 1(MCT1) inhibitor AZD3965 on the proliferation and apoptosis of gastric cancer BCG-823 cells,and explore its molecular mechanisms.Methods:The inhibitory effects of different concentrations of AZD3965(0,20,40 and 80 μmol/L) on the proliferation of gastric cancer cells were detected using MTT assay.The morphology changes of the gastric cancer BCG-823 cells treated with different concentrations of AZD3965(0,20,40 and 80 μmol/L) were observed using inverted microscope.The effect of AZD3965 on the colony forming ability of gastric cancer BCG-823 cells was observed using colony formation assay.The effect of AZD3965 on the apoptosis of gastric cancer BCG-823 cells was detected by flow cytometry with PI staining.The expression levels of MCT1,Bax and Bcl-2 protein were detected using Western blotting after treatment with AZD3965.Results:The cell proliferation of BCG-823 cells treated with AZD3965 was inhibited,and the inhibition effect of AZD3965 on the proliferation of BCG-823 cells significantly enhanced with the increasing of drug concentration and duration of action(P<0.01).After treatment of gastric cancer cells with AZD3965(20,40 and 80 μmol/L),the number of gastric cancer cells significantly reduced,the cells collapsed and ruptured,and the cell morphology changed under inverted microscope compared with the control group.The colony formation assay showed that AZD3965 could inhibit the proliferation of gastric cancer BCG-823 cells.The results of PI staining showed that the apoptosis rates of BCG-823 cells treated with AZD3965(20,40 and 80 μmol/L) for 24 h were (13.33±4.13)%,(22.53±2.97)% and(36.63±5.23)%,respectively,and the apoptosis rate significantly increased compared with the control group(P<0.01).Western blotting results showed that AZD3965 could down-regulate the expression levels of MCT1 and Bcl-2,and up-regulate the expression level of Bax in BCG-823 cells.Conclusions:AZD3965 can inhibit the proliferation of gastric cancer cells,and induce apoptosis by inhibiting the MCT1 activity,activating Bax and inhibiting Bcl-2.
Objective:To investigate the effect of monocarboxylate transporter 1(MCT1) inhibitor AZD3965 on the proliferation and apoptosis of gastric cancer BCG-823 cells,and explore its molecular mechanisms.Methods:The inhibitory effects of different concentrations of AZD3965(0,20,40 and 80 μmol/L) on the proliferation of gastric cancer cells were detected using MTT assay.The morphology changes of the gastric cancer BCG-823 cells treated with different concentrations of AZD3965(0,20,40 and 80 μmol/L) were observed using inverted microscope.The effect of AZD3965 on the colony forming ability of gastric cancer BCG-823 cells was observed using colony formation assay.The effect of AZD3965 on the apoptosis of gastric cancer BCG-823 cells was detected by flow cytometry with PI staining.The expression levels of MCT1,Bax and Bcl-2 protein were detected using Western blotting after treatment with AZD3965.Results:The cell proliferation of BCG-823 cells treated with AZD3965 was inhibited,and the inhibition effect of AZD3965 on the proliferation of BCG-823 cells significantly enhanced with the increasing of drug concentration and duration of action(P<0.01).After treatment of gastric cancer cells with AZD3965(20,40 and 80 μmol/L),the number of gastric cancer cells significantly reduced,the cells collapsed and ruptured,and the cell morphology changed under inverted microscope compared with the control group.The colony formation assay showed that AZD3965 could inhibit the proliferation of gastric cancer BCG-823 cells.The results of PI staining showed that the apoptosis rates of BCG-823 cells treated with AZD3965(20,40 and 80 μmol/L) for 24 h were (13.33±4.13)%,(22.53±2.97)% and(36.63±5.23)%,respectively,and the apoptosis rate significantly increased compared with the control group(P<0.01).Western blotting results showed that AZD3965 could down-regulate the expression levels of MCT1 and Bcl-2,and up-regulate the expression level of Bax in BCG-823 cells.Conclusions:AZD3965 can inhibit the proliferation of gastric cancer cells,and induce apoptosis by inhibiting the MCT1 activity,activating Bax and inhibiting Bcl-2.
2018, 43(12): 1546-1550.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.002
Abstract:
Objective:To study the expression levels and clinical significance of secretory crimp(sFRP1) and β-catenin in Wnt signaling pathway,and its correlation with HPV infection.Methods:The expression levels of sFRP1 and β-catenin protein in 60 cervical squamous cell carcinoma(SCC) cases,75 cervical intraepithelial neoplasia cases(including 15 cases of LSIL and 60 cases of HSIL) and 30 normal cervical tissue cases were detected using immunohistochemical SP method,and the HPV-DNA of cervical mucus exfoliated cells was detected using the hybrid capture(HC2) technology.Results:The expression levels of sFRP1 protein in cytomembrane of normal cervical tissue,cervical intraepithelial neoplasia and cervical squamous carcinoma gradually decreased,and the expression levels of β-catenin protein in cytoplasm and nucleus of normal cervical tissue,cervical intraepithelial neoplasia and cervical squamous carcinoma gradually increased.The differences of sFRP1 expression in SCC tissue with different pathological differentiation and infiltration depth were statistically significant(P<0.05),and the differences of β-catenin expression in SCC tissue with different FIGO stages and infiltration depth were statistically significant(P<0.05).In SCC tissue,the expression of β-catenin was negatively correlated with the expression of sFRP1(P<0.05),the expression of β-catenin was negatively correlated with HPV infection(P<0.01),and the expression of sFRP1 was negatively correlated with HPV infection(P<0.05).Conclusions:The combined detection of the expression of sFRP-1 and β-catenin,and HPV infection has important significance in judging the occurrence,development and prognosis of cervical cancer.
Objective:To study the expression levels and clinical significance of secretory crimp(sFRP1) and β-catenin in Wnt signaling pathway,and its correlation with HPV infection.Methods:The expression levels of sFRP1 and β-catenin protein in 60 cervical squamous cell carcinoma(SCC) cases,75 cervical intraepithelial neoplasia cases(including 15 cases of LSIL and 60 cases of HSIL) and 30 normal cervical tissue cases were detected using immunohistochemical SP method,and the HPV-DNA of cervical mucus exfoliated cells was detected using the hybrid capture(HC2) technology.Results:The expression levels of sFRP1 protein in cytomembrane of normal cervical tissue,cervical intraepithelial neoplasia and cervical squamous carcinoma gradually decreased,and the expression levels of β-catenin protein in cytoplasm and nucleus of normal cervical tissue,cervical intraepithelial neoplasia and cervical squamous carcinoma gradually increased.The differences of sFRP1 expression in SCC tissue with different pathological differentiation and infiltration depth were statistically significant(P<0.05),and the differences of β-catenin expression in SCC tissue with different FIGO stages and infiltration depth were statistically significant(P<0.05).In SCC tissue,the expression of β-catenin was negatively correlated with the expression of sFRP1(P<0.05),the expression of β-catenin was negatively correlated with HPV infection(P<0.01),and the expression of sFRP1 was negatively correlated with HPV infection(P<0.05).Conclusions:The combined detection of the expression of sFRP-1 and β-catenin,and HPV infection has important significance in judging the occurrence,development and prognosis of cervical cancer.
2018, 43(12): 1551-1554.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.003
Abstract:
Objective:To explore the effects of single-dose Kangai injectionon(KI) on the pharmacokinetic parameters of docetaxel in rats.Methods:Twenty-four SD rats were randomly divided into the control group,and high,medium and low drug combination groups.The control group was injected with docetaxel through caudal vein,and the high,medium and low drug combination groups were injected with 5.4,3.6 and 1.8 mL/kg of KI combined with docetaxel through caudal vein,respectively.The blood samples in four groups were collected at different time-points,the blood concentration of docetaxel was calculated by HPLC method,and the pharmacokinetic parameters of docetaxel were analyzed using DAS2.0.Results:Compared with the control group,the t1/2γ in low drug combination group significantly decreased(P<0.05),and the differences of the other pharmacokinetic parameters of docetaxel among other groups were not statistically significantly.Conclusions:The low-dose KI maybe affect the t1/2γ of docetaxel in rats,and the high and medium-dose KI do not significantly affect the pharmacokinetic parameters of docetaxel.
Objective:To explore the effects of single-dose Kangai injectionon(KI) on the pharmacokinetic parameters of docetaxel in rats.Methods:Twenty-four SD rats were randomly divided into the control group,and high,medium and low drug combination groups.The control group was injected with docetaxel through caudal vein,and the high,medium and low drug combination groups were injected with 5.4,3.6 and 1.8 mL/kg of KI combined with docetaxel through caudal vein,respectively.The blood samples in four groups were collected at different time-points,the blood concentration of docetaxel was calculated by HPLC method,and the pharmacokinetic parameters of docetaxel were analyzed using DAS2.0.Results:Compared with the control group,the t1/2γ in low drug combination group significantly decreased(P<0.05),and the differences of the other pharmacokinetic parameters of docetaxel among other groups were not statistically significantly.Conclusions:The low-dose KI maybe affect the t1/2γ of docetaxel in rats,and the high and medium-dose KI do not significantly affect the pharmacokinetic parameters of docetaxel.
2018, 43(12): 1555-1557.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.004
Abstract:
Objective:To investigate the clinical effects of Donati-Allgower method in suturing the calcaneal fracture incision.Methods:Fifty calcaneal fracture patients treated with open reduction and internal fixation were randomly divided into the observation group(24 cases) and control group(26 cases) according to the admission order.The observation group were treated with Allgower-Donati method suturing incision,and the control group were treated with vertical mattress method suturing incision.The clinical curative effect and wound healing in two groups were observed after 3 months of surgery.Results:The excellent and good rate in observation group(91.67%) was higher than that in control group(65.38%)(P<0.05),and the incidence rate of incision complication in observation group(4.17%) was lower than that in control group(30.77%)(P<0.05).Conclusions:The Allgower-Donati suture technique in suturing calcaneal fracture incision is simple operation,which can effectively protect the blood supply of flap,reduce the surgical incision necrosis and infection,and is worthy of clinical application.
Objective:To investigate the clinical effects of Donati-Allgower method in suturing the calcaneal fracture incision.Methods:Fifty calcaneal fracture patients treated with open reduction and internal fixation were randomly divided into the observation group(24 cases) and control group(26 cases) according to the admission order.The observation group were treated with Allgower-Donati method suturing incision,and the control group were treated with vertical mattress method suturing incision.The clinical curative effect and wound healing in two groups were observed after 3 months of surgery.Results:The excellent and good rate in observation group(91.67%) was higher than that in control group(65.38%)(P<0.05),and the incidence rate of incision complication in observation group(4.17%) was lower than that in control group(30.77%)(P<0.05).Conclusions:The Allgower-Donati suture technique in suturing calcaneal fracture incision is simple operation,which can effectively protect the blood supply of flap,reduce the surgical incision necrosis and infection,and is worthy of clinical application.
2018, 43(12): 1558-1560.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.005
Abstract:
Objective:To investigate the relationship between the serum level of Ghrelin and progression of atrial fibrillation(AF).Methods:The serum levels of Ghrelin in 80 patients with persistent AF(AF group) and 80 patients with sinus arrhythmia(SA)(SA group) were tested using ELISA.The blood glucose,lipid,liver and kidney function,and echocardiography in two groups were measured.All indexes in AF patients were detected after 8 weeks of conventional treatment.Results:The serum level of Ghrelin in AF group was significantly lower than that in SA group(P<0.01).The serum level of Ghrelin was positively correlated with LVEF in AF group(r=0.698,P<0.05).After treatment,the serum levels of Ghrelin and LVEF significantly increased,and the LAD level decreased in AF group.Conclusions:The serum level of Ghrelin is positively correlated with LVEF in patients with AF,regular examination of Ghrelin levels contributes to the progress of AF diagnosis.
Objective:To investigate the relationship between the serum level of Ghrelin and progression of atrial fibrillation(AF).Methods:The serum levels of Ghrelin in 80 patients with persistent AF(AF group) and 80 patients with sinus arrhythmia(SA)(SA group) were tested using ELISA.The blood glucose,lipid,liver and kidney function,and echocardiography in two groups were measured.All indexes in AF patients were detected after 8 weeks of conventional treatment.Results:The serum level of Ghrelin in AF group was significantly lower than that in SA group(P<0.01).The serum level of Ghrelin was positively correlated with LVEF in AF group(r=0.698,P<0.05).After treatment,the serum levels of Ghrelin and LVEF significantly increased,and the LAD level decreased in AF group.Conclusions:The serum level of Ghrelin is positively correlated with LVEF in patients with AF,regular examination of Ghrelin levels contributes to the progress of AF diagnosis.
2018, 43(12): 1561-1564.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.006
Abstract:
Objective:To compare the clinical efficacy and untoward effect between etonogestrel implant and levonorgestrel-releasing intrauterine system(LNG-IUS) in the treatment of adenomyosis,and provide a new treatment method for adenomyosis.Methods:Thirty adenomyosis patients treated with etonogestrel implant and 30 adenomyosis patients treated with LNG-IUS were divided into the observation group and control group,respectively.The dysmenorrheal degree,menstrual blood volume,volume of uterus,menstrual pattern and hormone-related adverse reactions between two groups were compared after treatment.Results:The difference of the score of dysmenorrheal between two groups was not statistically significant before treatment(P>0.05),and the scores of dysmenorrheal in two groups at each time-point gradually decreased after 1 to 12 months of treatment(P<0.01).At 1 and 6 months of treatment,the differences of the scores of dysmenorrheal between two groups were statistically significant(P<0.05 and P<0.01).The menstrual blood volume in two groups decreased after 1 month of treatment(P<0.05),and the decreasing degree of which in control group was more obvious at 12 months of treatment(P<0.05).Compared with before treatment,the uterine volume in two groups decreased after 3 months of treatment(P<0.05),and the difference of the treatment effect between two groups was not statistically significant(P>0.05).The differences of the body mass increasing,and incidence rates of acne and breast swelling pain between two groups were not statistically significant(P>0.05).The difference of menstrual pattern between two groups was statistically significant(P<0.05),and the menstrual period prolonging and frequence of menstrual cycle increasing were more common in observation group.Conclusions:Both etonogestrel implant and LNG-IUS can be used to treat adenomyosis,and the effect between two methods is similar.After etonogestrel implant,the menstrual period prolonging and frequency of menstruation increasing are common.In the treatment of adenomyosis,the etonogestrel implant can be used as an alternative to the intrauterine sustained-release system of LNG-IUS.
Objective:To compare the clinical efficacy and untoward effect between etonogestrel implant and levonorgestrel-releasing intrauterine system(LNG-IUS) in the treatment of adenomyosis,and provide a new treatment method for adenomyosis.Methods:Thirty adenomyosis patients treated with etonogestrel implant and 30 adenomyosis patients treated with LNG-IUS were divided into the observation group and control group,respectively.The dysmenorrheal degree,menstrual blood volume,volume of uterus,menstrual pattern and hormone-related adverse reactions between two groups were compared after treatment.Results:The difference of the score of dysmenorrheal between two groups was not statistically significant before treatment(P>0.05),and the scores of dysmenorrheal in two groups at each time-point gradually decreased after 1 to 12 months of treatment(P<0.01).At 1 and 6 months of treatment,the differences of the scores of dysmenorrheal between two groups were statistically significant(P<0.05 and P<0.01).The menstrual blood volume in two groups decreased after 1 month of treatment(P<0.05),and the decreasing degree of which in control group was more obvious at 12 months of treatment(P<0.05).Compared with before treatment,the uterine volume in two groups decreased after 3 months of treatment(P<0.05),and the difference of the treatment effect between two groups was not statistically significant(P>0.05).The differences of the body mass increasing,and incidence rates of acne and breast swelling pain between two groups were not statistically significant(P>0.05).The difference of menstrual pattern between two groups was statistically significant(P<0.05),and the menstrual period prolonging and frequence of menstrual cycle increasing were more common in observation group.Conclusions:Both etonogestrel implant and LNG-IUS can be used to treat adenomyosis,and the effect between two methods is similar.After etonogestrel implant,the menstrual period prolonging and frequency of menstruation increasing are common.In the treatment of adenomyosis,the etonogestrel implant can be used as an alternative to the intrauterine sustained-release system of LNG-IUS.
2018, 43(12): 1565-1568.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.007
Abstract:
Objective:To compare the clinical efficacy between rivaroxaban and low molecular weight heparin calcium injection in the prevention of deep venous thrombosis after hip and knee joint arthroplasty,and guide clinical rational use of anticoagulant.Methods:One hundred patients with hip and knee arthroplasty were randomly divided into the rivaroxaban group and low molecular weight heparin group(50 cases each group).The rivaroxaban group was treated with 10 mg of rivaroxaban once daily by oral after 8 hours of operation,and the low molecular weight heparin group was treated with 5 000 AXaIU of low molecular weight heparin once daily by subcutaneous injection after 12 hours of operation.Two groups were continuously treated for 2 weeks.The blood coagulation indexes[including platelet,activated partial thromboplastin,prothrombin time and incidence rate of lower extremity deep venous thrombosis(DVT)] were compared between two groups.Clinical pharmacists participated in the treatment process,and provided pharmaceutical care.Results:The platelet counts and coagulation parameters in two groups were normal before surgery,and the difference of which was not statistically significant between two groups(P>0.05).The platelet counts and coagulation parameters in the two groups were normal before treatment and after 14 days of treatment,and the difference of which was not statistically significant between in two groups(P>0.05).The incidence rates of DVT in rivaroxaban group and low molecular weight heparin group were 0%(0/50) and 8%(4/50),respectively,and the difference of which was statistically significant between the two groups(P<0.05).The incidence rates of adverse reactions in rivaroxaban group and low molecular weight heparin group were 2%(1/50) and 12%(6/50),respectively,and the difference of which was not statistically significant between the two groups(P>0.05).Conclusions:Rivaroxaban can effectively prevent the occurrence of thrombosis in lower extremities deep vein after hip and knee joint arthroplasty,does not increase the risk of bleeding and has good safety,and the curative effect of which is equivalent to low molecular weight heparin.Rivaroxaban has the advantages of oral administration,fixed dose,satisfactory efficacy,and need not monitor.
Objective:To compare the clinical efficacy between rivaroxaban and low molecular weight heparin calcium injection in the prevention of deep venous thrombosis after hip and knee joint arthroplasty,and guide clinical rational use of anticoagulant.Methods:One hundred patients with hip and knee arthroplasty were randomly divided into the rivaroxaban group and low molecular weight heparin group(50 cases each group).The rivaroxaban group was treated with 10 mg of rivaroxaban once daily by oral after 8 hours of operation,and the low molecular weight heparin group was treated with 5 000 AXaIU of low molecular weight heparin once daily by subcutaneous injection after 12 hours of operation.Two groups were continuously treated for 2 weeks.The blood coagulation indexes[including platelet,activated partial thromboplastin,prothrombin time and incidence rate of lower extremity deep venous thrombosis(DVT)] were compared between two groups.Clinical pharmacists participated in the treatment process,and provided pharmaceutical care.Results:The platelet counts and coagulation parameters in two groups were normal before surgery,and the difference of which was not statistically significant between two groups(P>0.05).The platelet counts and coagulation parameters in the two groups were normal before treatment and after 14 days of treatment,and the difference of which was not statistically significant between in two groups(P>0.05).The incidence rates of DVT in rivaroxaban group and low molecular weight heparin group were 0%(0/50) and 8%(4/50),respectively,and the difference of which was statistically significant between the two groups(P<0.05).The incidence rates of adverse reactions in rivaroxaban group and low molecular weight heparin group were 2%(1/50) and 12%(6/50),respectively,and the difference of which was not statistically significant between the two groups(P>0.05).Conclusions:Rivaroxaban can effectively prevent the occurrence of thrombosis in lower extremities deep vein after hip and knee joint arthroplasty,does not increase the risk of bleeding and has good safety,and the curative effect of which is equivalent to low molecular weight heparin.Rivaroxaban has the advantages of oral administration,fixed dose,satisfactory efficacy,and need not monitor.
2018, 43(12): 1569-1571,1574.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.008
Abstract:
Objective:To investigate the clinical effects of artificial liver plasma replacement in the treatment of liver failure in 40 patients,and evaluate the value of model for end-stage liver disease(MELD) score in predicting the prognosis of liver failure.Methods:The clinical data of 40 liver failure patients treated with artificial liver plasma replacement were retrospectively analyzed.The clinical effects and MELD scores of the patients were evaluated,and the clinical outcome of the patients was observed.Results:After the plasma replacement,the levels of ALT,AST,TBIL,Cr,PT and INR significantly decreased(P<0.05 to P<0.01),and the levels of CHE,ALB and PTA significantly increased compared with before treatment(P<0.01).The patients were treated with artificial liver plasma replacement for 140 times,the adverse reactions occurred in 4 times,and the incidence rate of which was 2.8%.Thirty cases were effective,10 cases were invalid,and the effective rate of which was 75%.The invalid rate of artificial liver treatment in three groups with high MELD scores was higher,and the difference of invalid rate was not statistically significant(P>0.05).Conclusions:The plasma replacement has good clinical effects and few adverse reactions.MELD sore as a predicting prognosis indictor of plasma replacement treating liver failure needs further research.
Objective:To investigate the clinical effects of artificial liver plasma replacement in the treatment of liver failure in 40 patients,and evaluate the value of model for end-stage liver disease(MELD) score in predicting the prognosis of liver failure.Methods:The clinical data of 40 liver failure patients treated with artificial liver plasma replacement were retrospectively analyzed.The clinical effects and MELD scores of the patients were evaluated,and the clinical outcome of the patients was observed.Results:After the plasma replacement,the levels of ALT,AST,TBIL,Cr,PT and INR significantly decreased(P<0.05 to P<0.01),and the levels of CHE,ALB and PTA significantly increased compared with before treatment(P<0.01).The patients were treated with artificial liver plasma replacement for 140 times,the adverse reactions occurred in 4 times,and the incidence rate of which was 2.8%.Thirty cases were effective,10 cases were invalid,and the effective rate of which was 75%.The invalid rate of artificial liver treatment in three groups with high MELD scores was higher,and the difference of invalid rate was not statistically significant(P>0.05).Conclusions:The plasma replacement has good clinical effects and few adverse reactions.MELD sore as a predicting prognosis indictor of plasma replacement treating liver failure needs further research.
2018, 43(12): 1572-1574.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.009
Abstract:
Objective:To discuss the clinical effectiveness and safety of the curettage combined with uterine artery embolization in the treatment of endogenic cesarean scar pregnancy(CSP).Methods:Seventy patients with endogenic CSP were treated with uterine curettage guided by color Doppler ultrasound after 72h of uterine artery embolization.The successful rate of abortion,peroperative bleeding,postoperative bleeding,intrauterine residue,time of β-hCG andmenstruation returning to normal,and complication in all patients were observed.Results:All operations in 70 cases were successfully,and the abortion rate was 98.57%(69/70).The mean bleeding during operation was(23.33+47.22)mL.The time of β-hCG and menstruation returning to normal were(20.73±5.53) and(40.97±8.97) days after operation,respectively.There was no intrauterine residue under abdominal color Doppler ultrasound after 1 week of curettage.There was no complication among all patients.Conclusions:The curettage combined with uterine artery embolization in the treatment of CSP has high success rate,less bleeding,fewer complications,is safe and effective,which is worthy of clinical promotion.
Objective:To discuss the clinical effectiveness and safety of the curettage combined with uterine artery embolization in the treatment of endogenic cesarean scar pregnancy(CSP).Methods:Seventy patients with endogenic CSP were treated with uterine curettage guided by color Doppler ultrasound after 72h of uterine artery embolization.The successful rate of abortion,peroperative bleeding,postoperative bleeding,intrauterine residue,time of β-hCG andmenstruation returning to normal,and complication in all patients were observed.Results:All operations in 70 cases were successfully,and the abortion rate was 98.57%(69/70).The mean bleeding during operation was(23.33+47.22)mL.The time of β-hCG and menstruation returning to normal were(20.73±5.53) and(40.97±8.97) days after operation,respectively.There was no intrauterine residue under abdominal color Doppler ultrasound after 1 week of curettage.There was no complication among all patients.Conclusions:The curettage combined with uterine artery embolization in the treatment of CSP has high success rate,less bleeding,fewer complications,is safe and effective,which is worthy of clinical promotion.
2018, 43(12): 1575-1577.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.010
Abstract:
Objective:To explore the expression of CXCL13 in triple-negative breast cancer(TNBC),and its correlation with clinical pathology and prognosis.Methods:The expression levels of CXCL13 in 73 TNBC tissue samples and 24 paracancerous normal breast tissue samples were detected using immunohistochemical staining,and the correlation of the CXCL13 expression levels with clinical pathology and prognosis was analyzed.Results:The expression level of CXCL13 in TNBC tissue was higher than that in paracancerous normal breast tissue(P<0.01),the differences of the CXCL13 expression in different node metastasis and clinical stages were statistically significant(P<0.05 to P<0.01),the CXCL13 expression in patients with node metastasis was significantly higher than that in patients without node metastasis(P<0.01),and the CXCL13 expression level in stage Ⅰ/Ⅱ patients was significantly lower than that in stage Ⅲ patients(P<0.05).The differences of CXCL13 expression levels in different age,tumor size,menopausal status and differentiation degree of tumor were not statistically significant(P>0.05).The five-year survival rate in patients with high CXCL13 expression(49.1%) was lower than that in patients with low CXCL13 expression(82.9%)(χ2=6.49,P<0.05).Conclusions:The CXCL13 expression is related to the progress of TNBC,and CXCL13 may be an independent prognosis factor for TNBC.
Objective:To explore the expression of CXCL13 in triple-negative breast cancer(TNBC),and its correlation with clinical pathology and prognosis.Methods:The expression levels of CXCL13 in 73 TNBC tissue samples and 24 paracancerous normal breast tissue samples were detected using immunohistochemical staining,and the correlation of the CXCL13 expression levels with clinical pathology and prognosis was analyzed.Results:The expression level of CXCL13 in TNBC tissue was higher than that in paracancerous normal breast tissue(P<0.01),the differences of the CXCL13 expression in different node metastasis and clinical stages were statistically significant(P<0.05 to P<0.01),the CXCL13 expression in patients with node metastasis was significantly higher than that in patients without node metastasis(P<0.01),and the CXCL13 expression level in stage Ⅰ/Ⅱ patients was significantly lower than that in stage Ⅲ patients(P<0.05).The differences of CXCL13 expression levels in different age,tumor size,menopausal status and differentiation degree of tumor were not statistically significant(P>0.05).The five-year survival rate in patients with high CXCL13 expression(49.1%) was lower than that in patients with low CXCL13 expression(82.9%)(χ2=6.49,P<0.05).Conclusions:The CXCL13 expression is related to the progress of TNBC,and CXCL13 may be an independent prognosis factor for TNBC.
2018, 43(12): 1578-1580.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.011
Abstract:
Objective:To investigate the effects of rehabilitation therapy on motor function and activities of daily living in patients with unilateral spatial neglect after stroke.Methods:Thirty-six patients with unilateral spatial neglect after stroke were treated with visual sensory,physical exercise and psychological rehabilitation.The recovery of motor function and activities of daily living between before and after treatment were compared.Results:The NIHSS scores after 1 month,2 months and 3 months of rehabilitation therapy were significantly lower than that before treatment(P<0.01),and the longer the rehabilitation treatment time,the lower the NIHSS score was(P<0.01).The BI score after treatment was significantly higher than that before treatment(P<0.01),but the difference of which at different time-points after treatment was not statistically significant(P>0.05).The difference of BI index between left-side and right-side spatial neglect patients was not statistically significant(P>0.05).Conclusions:The visual sensory,physical exercise and psychological rehabilitation in the treatment of unilateral spatial neglect can significantly improve motor function and activities of daily living,and effectively improve the quality of life in patients with stroke,which is worthy of promotion.
Objective:To investigate the effects of rehabilitation therapy on motor function and activities of daily living in patients with unilateral spatial neglect after stroke.Methods:Thirty-six patients with unilateral spatial neglect after stroke were treated with visual sensory,physical exercise and psychological rehabilitation.The recovery of motor function and activities of daily living between before and after treatment were compared.Results:The NIHSS scores after 1 month,2 months and 3 months of rehabilitation therapy were significantly lower than that before treatment(P<0.01),and the longer the rehabilitation treatment time,the lower the NIHSS score was(P<0.01).The BI score after treatment was significantly higher than that before treatment(P<0.01),but the difference of which at different time-points after treatment was not statistically significant(P>0.05).The difference of BI index between left-side and right-side spatial neglect patients was not statistically significant(P>0.05).Conclusions:The visual sensory,physical exercise and psychological rehabilitation in the treatment of unilateral spatial neglect can significantly improve motor function and activities of daily living,and effectively improve the quality of life in patients with stroke,which is worthy of promotion.
2018, 43(12): 1581-1584.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.012
Abstract:
Objective:To investigate the correlation between the preoperative plasma level of glutathione peroxidase-6(GPX6) and occurrence of postoperative atrial fibrillation(POAF) after coronary artery bypass grafting(CABG).Methods:Forty patients with POAF and 40 patients without POAF after CABG were divided into the POAF(+) group and POAF(-) group by nested case-control study.The plasma levels of GPX6 in two groups before operation were measured and compared.The correlation between GPX6 level and POAF was evaluated using multivariable analysis method,and the diagnostic value of GPX6 for POAF was evaluated using receiver operating characteristic(ROC) curve analysis.Results:The plasma level of GPX6 in POAF(+) group was significantly higher than that in POAF(-) group(P<0.01).After some correlated variables were adjusted,the plasma level of GPX6 still was the independent predict factor of POAF(OR=1.10,95%CI 1.01 to 1.19,P<0.05).The ROC analysis demonstrated that the area under curve of GPX6 for POAF was 0.65(95%CI 0.53 to 0.77).Conclusions:The preoperative plasma level of GPX6 in patients with POAF after CABG is higher than that in patients without POAF,and GPX6 is an independent predict factor of POAF and has certain diagnostic value for POAF.
Objective:To investigate the correlation between the preoperative plasma level of glutathione peroxidase-6(GPX6) and occurrence of postoperative atrial fibrillation(POAF) after coronary artery bypass grafting(CABG).Methods:Forty patients with POAF and 40 patients without POAF after CABG were divided into the POAF(+) group and POAF(-) group by nested case-control study.The plasma levels of GPX6 in two groups before operation were measured and compared.The correlation between GPX6 level and POAF was evaluated using multivariable analysis method,and the diagnostic value of GPX6 for POAF was evaluated using receiver operating characteristic(ROC) curve analysis.Results:The plasma level of GPX6 in POAF(+) group was significantly higher than that in POAF(-) group(P<0.01).After some correlated variables were adjusted,the plasma level of GPX6 still was the independent predict factor of POAF(OR=1.10,95%CI 1.01 to 1.19,P<0.05).The ROC analysis demonstrated that the area under curve of GPX6 for POAF was 0.65(95%CI 0.53 to 0.77).Conclusions:The preoperative plasma level of GPX6 in patients with POAF after CABG is higher than that in patients without POAF,and GPX6 is an independent predict factor of POAF and has certain diagnostic value for POAF.
2018, 43(12): 1585-1587.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.013
Abstract:
Objective:To investigate the expression levels of chemokine receptor CXCR4 and its ligand SDF-1α in peripheral blood of patients with rheumatoid arthritis.Methods:Fifty-two patients with rheumatoid arthritis and 30 healthy people were divided into the observation group and control group,respectively.The levels of CXCR4,SDF-1α and IL-8 in peripheral blood of two groups were measured.Results:The expression rates of CXCR4 on the surface of CD3+CD4+ and CD3+CD8+ T lymphocytes,and levels of SDF-1α and IL-8 in peripheral blood of observation group were significantly higher than those in control group(P<0.05).With the prolonging of disease course,the expression rates of CXCR4 on the surface of CD3+CD4+ and CD3+CD8+ T lymphocytes,and level of SDF-1α in peripheral blood of observation group increased(P<0.05).Linear correlation analysis showed that the expression levels of CXCR4 and SDF-1α were positive correlation with IL-8 in peripheral blood(P<0.05).Conclusions:The signal transduction pathway of SDF-1α/CXCR4 and IL-8 may be involved in the pathogenesis and progression of rheumatoid arthritis.
Objective:To investigate the expression levels of chemokine receptor CXCR4 and its ligand SDF-1α in peripheral blood of patients with rheumatoid arthritis.Methods:Fifty-two patients with rheumatoid arthritis and 30 healthy people were divided into the observation group and control group,respectively.The levels of CXCR4,SDF-1α and IL-8 in peripheral blood of two groups were measured.Results:The expression rates of CXCR4 on the surface of CD3+CD4+ and CD3+CD8+ T lymphocytes,and levels of SDF-1α and IL-8 in peripheral blood of observation group were significantly higher than those in control group(P<0.05).With the prolonging of disease course,the expression rates of CXCR4 on the surface of CD3+CD4+ and CD3+CD8+ T lymphocytes,and level of SDF-1α in peripheral blood of observation group increased(P<0.05).Linear correlation analysis showed that the expression levels of CXCR4 and SDF-1α were positive correlation with IL-8 in peripheral blood(P<0.05).Conclusions:The signal transduction pathway of SDF-1α/CXCR4 and IL-8 may be involved in the pathogenesis and progression of rheumatoid arthritis.
2018, 43(12): 1588-1590.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.014
Abstract:
Objective:To investigate the effects of triiodothyronine 3(T3) level on the prognosis of patients with acute respiratory distress syndrome(ARDS).Methods:Forty patients with ARDS were divided into the survival group and death group according to the hospitalization 30 days outcome.The age,APACHE Ⅱ score,levels of Calcitonin,hypersensitive c-reactive protein,white blood cell count,pH,lactic acid,FT3,free thyroxine and thyroid-stimulating hormone between two groups were compared,and the influencing factors of hospitalization 30 days outcome were analyzed.Results:The level of T3 in death group was significantly lower than that in survival group on the first day of ARDS diagnosis (P<0.05).The level of T3 on the first day in survival group was significantly lower than that on the third day(P<0.01),and no obvious change in T3 level was found in death group(P>0.05).The results of multivariate logistic regression analysis showed that the FT3 level and APACHEⅡ score were the influencing factors of hospitalization 30 days outcome(P<0.05).Conclusions:The detection of T3 level can help to assess the severity of ARDS,and predict the prognosis of patients.
Objective:To investigate the effects of triiodothyronine 3(T3) level on the prognosis of patients with acute respiratory distress syndrome(ARDS).Methods:Forty patients with ARDS were divided into the survival group and death group according to the hospitalization 30 days outcome.The age,APACHE Ⅱ score,levels of Calcitonin,hypersensitive c-reactive protein,white blood cell count,pH,lactic acid,FT3,free thyroxine and thyroid-stimulating hormone between two groups were compared,and the influencing factors of hospitalization 30 days outcome were analyzed.Results:The level of T3 in death group was significantly lower than that in survival group on the first day of ARDS diagnosis (P<0.05).The level of T3 on the first day in survival group was significantly lower than that on the third day(P<0.01),and no obvious change in T3 level was found in death group(P>0.05).The results of multivariate logistic regression analysis showed that the FT3 level and APACHEⅡ score were the influencing factors of hospitalization 30 days outcome(P<0.05).Conclusions:The detection of T3 level can help to assess the severity of ARDS,and predict the prognosis of patients.
2018, 43(12): 1591-1594,1598.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.015
Abstract:
Objective:To evaluate the clinical efficacy of vesselplasty in the treatment of thoracolumbar osteoporotic vertebral compression fractures.Methods:The clinical data of 60 patients with osteoporotic vertebral compression were retrospectively analyzed.According to the surgical procedures,the patients were divided into the observation group(treated with vesselplasty) and control group(treated with traditional kyphoplasty)(30 cases each group).Two groups were followed up for 4-12 months.The operation condition,scores of VAS and ODI,anterior vertebral body height,Cobb angle and bone cement leakage between two groups were compared.Results:The differences of the intraoperative bleeding and operation time between two groups were not statistically significant(P>0.05).The differences of the scores of VAS and ODI at all time-point between two groups were not statistically significant(P>0.05),and the scores of VAS and ODI in two groups after 24 h of operation and at the end of following up were significantly lower than those before operation(P<0.01).The differences of the anterior vertebral body height and Cobb angle between two groups at the same time-point were not statistically significant(P>0.05).The average correction value of Cobb angle in observation group and control group were (6.8±3.5)° and (7.9±3.1)°,respectively,and the difference of which was not statistically significant(P>0.05).The differences of the anterior vertebral body height and Cobb angle in two groups between before operation,and after 24 h of operation and at the end of following up were statistically significant(P<0.01).The bone cement leakage was not found in observation group,the bone cement leakage rate in control group was 22.6%(7/31),and the difference of which between two groups was statistically significant(P<0.05).Conclusions:The treatment of thoracolumbar osteoporotic vertebral compression fractures with vesselplasty is safe and effective,which can avoid the cement leakage,especially in the fractures with posterior wall damage.
Objective:To evaluate the clinical efficacy of vesselplasty in the treatment of thoracolumbar osteoporotic vertebral compression fractures.Methods:The clinical data of 60 patients with osteoporotic vertebral compression were retrospectively analyzed.According to the surgical procedures,the patients were divided into the observation group(treated with vesselplasty) and control group(treated with traditional kyphoplasty)(30 cases each group).Two groups were followed up for 4-12 months.The operation condition,scores of VAS and ODI,anterior vertebral body height,Cobb angle and bone cement leakage between two groups were compared.Results:The differences of the intraoperative bleeding and operation time between two groups were not statistically significant(P>0.05).The differences of the scores of VAS and ODI at all time-point between two groups were not statistically significant(P>0.05),and the scores of VAS and ODI in two groups after 24 h of operation and at the end of following up were significantly lower than those before operation(P<0.01).The differences of the anterior vertebral body height and Cobb angle between two groups at the same time-point were not statistically significant(P>0.05).The average correction value of Cobb angle in observation group and control group were (6.8±3.5)° and (7.9±3.1)°,respectively,and the difference of which was not statistically significant(P>0.05).The differences of the anterior vertebral body height and Cobb angle in two groups between before operation,and after 24 h of operation and at the end of following up were statistically significant(P<0.01).The bone cement leakage was not found in observation group,the bone cement leakage rate in control group was 22.6%(7/31),and the difference of which between two groups was statistically significant(P<0.05).Conclusions:The treatment of thoracolumbar osteoporotic vertebral compression fractures with vesselplasty is safe and effective,which can avoid the cement leakage,especially in the fractures with posterior wall damage.
2018, 43(12): 1595-1598.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.016
Abstract:
Objective:To observe the effects of dexmedetomidine,creatine phosphate sodium,dexmedetomidine combined with creatine phosphate sodium on postoperative cognitive function in elderly patients after general anesthesia.Methods:Sixty elderly patients treated with esophageal cancer radical surgery under general anesthesia were randomly divided into the dexmedetomidine group(group D),creatine phosphate sodium group(group CP),dexmedetomidine combined with creatine phosphate sodium group(group DCP) and 0.9% sodium chloride injection blank control group(group C).The ECG,BP,SpO2,PetCO2 and BIS in four groups were monitored.After starting anesthesia,the anesthesia induction and maintenance in four groups were the same.The MMSE and VAS scores in four groups were recorded before anesthesia,and after 3 h,1 d and 2 d of surgery.Results:There was no statistical significance in VAS scores among four groups at each time period(P>0.05).The MMSE scores in groups C,D and CP after 3 h,1 d and 2 d of surgery were significantly lower than those before surgery(P<0.01).The MMSE score in group DCP after 3 h of surgery was significantly lower than that before surgery(P<0.05),and the difference of which between postoperative 1 d and 2 d was not statistically significant(P>0.05).The MMSE scores in groups D,CP and DCP were significantly higher than those in group C after operaation(P<0.05 to P<0.01).The differences of the incidence rate of postoperative cognitive dysfunction among groups D,CP,C were not statistically significant after operation(P>0.05).The incidence rate of postoperative cognitive dysfunction in group DCP after surgery was lower than that in group C(P<0.05),but the difference of which between group DCP and group C or group D was not statistically significant(P>0.05).Conclusions:Creatine phosphate sodium dexmedetomidine can effectively improve cognitive function,and reduce the incidence rate of postoperative cognitive dysfunction in elderly patients after general anesthesia.The effect of combination of two drugs is better.
Objective:To observe the effects of dexmedetomidine,creatine phosphate sodium,dexmedetomidine combined with creatine phosphate sodium on postoperative cognitive function in elderly patients after general anesthesia.Methods:Sixty elderly patients treated with esophageal cancer radical surgery under general anesthesia were randomly divided into the dexmedetomidine group(group D),creatine phosphate sodium group(group CP),dexmedetomidine combined with creatine phosphate sodium group(group DCP) and 0.9% sodium chloride injection blank control group(group C).The ECG,BP,SpO2,PetCO2 and BIS in four groups were monitored.After starting anesthesia,the anesthesia induction and maintenance in four groups were the same.The MMSE and VAS scores in four groups were recorded before anesthesia,and after 3 h,1 d and 2 d of surgery.Results:There was no statistical significance in VAS scores among four groups at each time period(P>0.05).The MMSE scores in groups C,D and CP after 3 h,1 d and 2 d of surgery were significantly lower than those before surgery(P<0.01).The MMSE score in group DCP after 3 h of surgery was significantly lower than that before surgery(P<0.05),and the difference of which between postoperative 1 d and 2 d was not statistically significant(P>0.05).The MMSE scores in groups D,CP and DCP were significantly higher than those in group C after operaation(P<0.05 to P<0.01).The differences of the incidence rate of postoperative cognitive dysfunction among groups D,CP,C were not statistically significant after operation(P>0.05).The incidence rate of postoperative cognitive dysfunction in group DCP after surgery was lower than that in group C(P<0.05),but the difference of which between group DCP and group C or group D was not statistically significant(P>0.05).Conclusions:Creatine phosphate sodium dexmedetomidine can effectively improve cognitive function,and reduce the incidence rate of postoperative cognitive dysfunction in elderly patients after general anesthesia.The effect of combination of two drugs is better.
2018, 43(12): 1599-1602.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.017
Abstract:
Objective:To investigate the effects of extralevator abdominoperineal excision(ELAPE) on short-term prognosis in patients with low rectal cancer,and provide the basis in improving the short-term prognosis of patients.Methods:According to the different surgical methods,67 patients with low rectal cancer were divided into the abdomino-perineal resection(APE) group(n=31) and ELAPE group(n=36).The operation situation,postoperative recovery,incidence rate of complications and postoperative follow-up result were compared between two groups.Results:The operation time in ELAPE group was significantly longer than that in APE group,and the peroperative bleeding and positive rate of circumferential margin in ELAPE group was significantly lower than those in APE group(P<0.05 to P<0.01).The differences of the number of lymph node dissection and perforation rate between two groups were not statistically significant(P>0.05).The removal time of perineal drain tube in ELAPE group was significantly higher than that in APE group(P<0.05).There were no statistical significance in the exhaust time,defecation time,feeding fluid time,perineal drainage volume,hospitalization time and perineal wound thread removal time between two groups(P>0.05).All patients were followed up for 6 to 24 months,the distant metastasis rate and mortality rate in ELAPE group were significantly lower than those in APE group(P<0.01 and P<0.05),and there was no statistical significance in the local recurrence rate between two groups(P>0.05).Conclusions:Compared with the traditional APE,ELAPE reduces the amount of bleeding,positive circumferential resection margin,incidence rate of distant metastasis and death rate,significantly improves the short-term prognosis of patients with low rectal cancer,which is worthy of attention.
Objective:To investigate the effects of extralevator abdominoperineal excision(ELAPE) on short-term prognosis in patients with low rectal cancer,and provide the basis in improving the short-term prognosis of patients.Methods:According to the different surgical methods,67 patients with low rectal cancer were divided into the abdomino-perineal resection(APE) group(n=31) and ELAPE group(n=36).The operation situation,postoperative recovery,incidence rate of complications and postoperative follow-up result were compared between two groups.Results:The operation time in ELAPE group was significantly longer than that in APE group,and the peroperative bleeding and positive rate of circumferential margin in ELAPE group was significantly lower than those in APE group(P<0.05 to P<0.01).The differences of the number of lymph node dissection and perforation rate between two groups were not statistically significant(P>0.05).The removal time of perineal drain tube in ELAPE group was significantly higher than that in APE group(P<0.05).There were no statistical significance in the exhaust time,defecation time,feeding fluid time,perineal drainage volume,hospitalization time and perineal wound thread removal time between two groups(P>0.05).All patients were followed up for 6 to 24 months,the distant metastasis rate and mortality rate in ELAPE group were significantly lower than those in APE group(P<0.01 and P<0.05),and there was no statistical significance in the local recurrence rate between two groups(P>0.05).Conclusions:Compared with the traditional APE,ELAPE reduces the amount of bleeding,positive circumferential resection margin,incidence rate of distant metastasis and death rate,significantly improves the short-term prognosis of patients with low rectal cancer,which is worthy of attention.
2018, 43(12): 1603-1605,1609.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.018
Abstract:
Objective:To investigate the clinical efficacy of ritodrine hydrochloride combined with magnesium sulfate in the treatment of preterm premature rupture of membranes.Methods:Ninety patients with preterm premature rupture of membranes were divided into the observation group and control group according to the random number table method(45 cases each group).The control group were treated with magnesium sulfate,and the observation group were additionally treated with ritodrine hydrochloride based on the control group.Results:The effective treatment rate in observation group(97.78%) was higher than that in control group(86.67%)(P<0.05).The anxiety in two groups were significantly improved after treatment(P<0.01),and the improvement in observation group was greater than that in control group(P<0.01).The time of contraction inhibition,pregnancy extension time,neonatal birth weight and Apgar score in observation group were significantly better than those in control group(P<0.01).The total incidence rate of neonatal complications in observation group was significantly lower than that in control group(P<0.05),but there was no statistical significance in the incidence rate of adverse reactions between two groups(P>0.05).Conclusions:Ritodrine hydrochloride combined with magnesium sulfate can inhibit the uterine contraction,prolong pregnancy,and improve the negative emotion and maternal and neonatal outcome in patients with preterm premature rupture of membranes,and the treatment effect of which is better than that of single magnesium sulfate.
Objective:To investigate the clinical efficacy of ritodrine hydrochloride combined with magnesium sulfate in the treatment of preterm premature rupture of membranes.Methods:Ninety patients with preterm premature rupture of membranes were divided into the observation group and control group according to the random number table method(45 cases each group).The control group were treated with magnesium sulfate,and the observation group were additionally treated with ritodrine hydrochloride based on the control group.Results:The effective treatment rate in observation group(97.78%) was higher than that in control group(86.67%)(P<0.05).The anxiety in two groups were significantly improved after treatment(P<0.01),and the improvement in observation group was greater than that in control group(P<0.01).The time of contraction inhibition,pregnancy extension time,neonatal birth weight and Apgar score in observation group were significantly better than those in control group(P<0.01).The total incidence rate of neonatal complications in observation group was significantly lower than that in control group(P<0.05),but there was no statistical significance in the incidence rate of adverse reactions between two groups(P>0.05).Conclusions:Ritodrine hydrochloride combined with magnesium sulfate can inhibit the uterine contraction,prolong pregnancy,and improve the negative emotion and maternal and neonatal outcome in patients with preterm premature rupture of membranes,and the treatment effect of which is better than that of single magnesium sulfate.
2018, 43(12): 1606-1609.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.019
Abstract:
Objective:To investigate the relationship between the expression of angiogenesis inhibitor 1(VASH1) and endoscopic manifestations in esophageal carcinoma.Methods:The expression levels of VASH1 in 120 paraffin embedded esophageal carcinoma samples and 50 normal esophageal tissues samples were detected using immunohistochemical SP method.The expression difference of VASH1 between esophageal carcinoma and normal esophageal tissue was analyzed.The expression levels of VASH1 in different IPCL types,and relationship between VASH1 expression and MVD in different differentiation tumors were analyzed.Results:The positive expression rates of VASH1 and VEGF in esophageal carcinoma were 54.17%(65/120) and 59.17%(71/120),respectively,and the positive expression rates of VASH1 and VEGF in normal VASH1 tissue were 8.0%(4/50) and 16.0%(8/50),respectively.The positive rates of VASH1 and VEGF in esophageal carcinoma were significantly higher than those in normal esophageal tissue(P<0.01).The expression level of VEGF was positively correlated with the expression of VASH1 in esophageal carcinoma,and the expression levels of VEGF and VASH1,depth of invasion and lymph node metastasis were the independent risk factors in influencing the prognosis of esophageal carcinoma(P<0.05 to P<0.01).The percentages of IPCL-Ⅴ and IPCL-Ⅳ were 54.79% and 56.82%,respectively,and the difference of which was not statistically significant(P>0.05).The differences of MVD value among the patients with negative,low and high VASH1 expressions were statistically significant(P<0.01).With the increasing of VASH1 expression level of patients,the MVD value increased,and the VASH1 expression was positively correlated with microvessel density(P<0.01).Conclusions:VASH1 may be closely related to the development of esophageal carcinoma and tumor cell formation,which has certain significance in predicting the prognosis of esophageal carcinoma.
Objective:To investigate the relationship between the expression of angiogenesis inhibitor 1(VASH1) and endoscopic manifestations in esophageal carcinoma.Methods:The expression levels of VASH1 in 120 paraffin embedded esophageal carcinoma samples and 50 normal esophageal tissues samples were detected using immunohistochemical SP method.The expression difference of VASH1 between esophageal carcinoma and normal esophageal tissue was analyzed.The expression levels of VASH1 in different IPCL types,and relationship between VASH1 expression and MVD in different differentiation tumors were analyzed.Results:The positive expression rates of VASH1 and VEGF in esophageal carcinoma were 54.17%(65/120) and 59.17%(71/120),respectively,and the positive expression rates of VASH1 and VEGF in normal VASH1 tissue were 8.0%(4/50) and 16.0%(8/50),respectively.The positive rates of VASH1 and VEGF in esophageal carcinoma were significantly higher than those in normal esophageal tissue(P<0.01).The expression level of VEGF was positively correlated with the expression of VASH1 in esophageal carcinoma,and the expression levels of VEGF and VASH1,depth of invasion and lymph node metastasis were the independent risk factors in influencing the prognosis of esophageal carcinoma(P<0.05 to P<0.01).The percentages of IPCL-Ⅴ and IPCL-Ⅳ were 54.79% and 56.82%,respectively,and the difference of which was not statistically significant(P>0.05).The differences of MVD value among the patients with negative,low and high VASH1 expressions were statistically significant(P<0.01).With the increasing of VASH1 expression level of patients,the MVD value increased,and the VASH1 expression was positively correlated with microvessel density(P<0.01).Conclusions:VASH1 may be closely related to the development of esophageal carcinoma and tumor cell formation,which has certain significance in predicting the prognosis of esophageal carcinoma.
2018, 43(12): 1610-1613.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.020
Abstract:
Objective:To investigate the effects of inverse ratio ventilation(IRV) on the airway pressure and perioperative PaCO2 in gynecologic patients treated with laparoscopic surgery.Methods:Sixty patients scheduled by laparoscopic resection for gynecologic tumor were randomly and double-blindly divided into the conventional ratio ventilation group(CRV group,I:E=1:2) and inverse ratio ventilation group(IRV group,I:E=2:1).The airway pressure and PaCO2 value at different time points during perioperative period between two groups were compared.Results:The peak and plat pressure at 60 min after pneumoperitoneum in IRV group were lower than those in CRV group(P<0.05~P<0.01).There was no statistical significance in PaCO2 value at all perioperative time points between two groups(P>0.05).Conclusions:IRV can effectively reduce the airway pressure in long-term pneumoperitoneum gynecological patients treated with laparoscopy,and has no effect on PaCO2 during perioperative period.
Objective:To investigate the effects of inverse ratio ventilation(IRV) on the airway pressure and perioperative PaCO2 in gynecologic patients treated with laparoscopic surgery.Methods:Sixty patients scheduled by laparoscopic resection for gynecologic tumor were randomly and double-blindly divided into the conventional ratio ventilation group(CRV group,I:E=1:2) and inverse ratio ventilation group(IRV group,I:E=2:1).The airway pressure and PaCO2 value at different time points during perioperative period between two groups were compared.Results:The peak and plat pressure at 60 min after pneumoperitoneum in IRV group were lower than those in CRV group(P<0.05~P<0.01).There was no statistical significance in PaCO2 value at all perioperative time points between two groups(P>0.05).Conclusions:IRV can effectively reduce the airway pressure in long-term pneumoperitoneum gynecological patients treated with laparoscopy,and has no effect on PaCO2 during perioperative period.
2018, 43(12): 1613-1615.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.021
Abstract:
Objective:To investigate the effects of hospital-family linkage intervention on the subjective quality of life and behavior problems in children with Tourette syndrome(TS) for providing a basis in comprehensive treatment.Methods:One hundred and ten TS children were randomly divided into the observation group(n=55) and control group(n=55).The control group was treated with conventional method,and the observation group was additionally treated with hospital-family linkage intervention based on the control group.The subjective quality of life and behavior problems in two groups before treatment and after 8 months of treatment were investigated using ISLQ and CBCL,and which was compared and analyzed.Results:After intervention,the total scores of subjective quality of life and behavior problems in observation group were significantly higher and lower than that in control group,respectively(P<0.01),and the understanding degree of TS and satisfaction degree in observation group significantly increased(P<0.01).Conclusions:The hospital-family linkage intervention can improve the subjective quality of life,and reduce the incidence of behavior problems of TS children,which can promote the physical and psychological rehabilitation of children with TS.
Objective:To investigate the effects of hospital-family linkage intervention on the subjective quality of life and behavior problems in children with Tourette syndrome(TS) for providing a basis in comprehensive treatment.Methods:One hundred and ten TS children were randomly divided into the observation group(n=55) and control group(n=55).The control group was treated with conventional method,and the observation group was additionally treated with hospital-family linkage intervention based on the control group.The subjective quality of life and behavior problems in two groups before treatment and after 8 months of treatment were investigated using ISLQ and CBCL,and which was compared and analyzed.Results:After intervention,the total scores of subjective quality of life and behavior problems in observation group were significantly higher and lower than that in control group,respectively(P<0.01),and the understanding degree of TS and satisfaction degree in observation group significantly increased(P<0.01).Conclusions:The hospital-family linkage intervention can improve the subjective quality of life,and reduce the incidence of behavior problems of TS children,which can promote the physical and psychological rehabilitation of children with TS.
2018, 43(12): 1616-1619.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.022
Abstract:
Objective:To investigate the effects and safety of the GnRHa combined with hormone in the treatment of endometriosis.Methods:One hundred and twenty-four patients with endometriosis were randomly divided into the control group and experimental group.Two groups were treated with conservative surgery,then the control group were additionally treated with Zoladex by subcutaneous injection,and the experimental group were additionally treated with Zoladex by subcutaneous injection combined with flexion progesterone and estradiol valerate by oral.The pain degrees of the pelvic pain,dyspareunia and dysmenorrhea were evaluated before and after treatment.The serum levels of estrogen(E2),LH and follicle stimulating hormone(FSH) at different time-points were measured.The incidence rate of insomnia,libido and bone pain in two groups were evaluated after treatment.Results:Before treatment,the differences of the scores of pelvic pain,dyspareunia and dysmenorrhea,and serum levels of E2,LH and FSH between two groups were not statistically significant(P>0.05).After treatment,the scores of pelvic pain and dyspareunia,and its pain degree in two groups significantly decreased compared before treatment(P<0.01),and the serum levels of LH and FSH were significantly lower than those before treatment(P<0.01).After treatment,the differences of the incidence rates of the insomnia,night sweat,sexual desire drop between two groups were not statistically significant(P>0.05),but the incidence rates of hectic fever,mood swing and bone pain in experimental group were significantly lower than those in control group(P<0.05).Conclusions:The GnRHa combined with hormone in the treatment of endometriosis can maintain the normal level of estrogen,improve menopausal symptoms and relieve pain,and which is worthy of clinical promotion.
Objective:To investigate the effects and safety of the GnRHa combined with hormone in the treatment of endometriosis.Methods:One hundred and twenty-four patients with endometriosis were randomly divided into the control group and experimental group.Two groups were treated with conservative surgery,then the control group were additionally treated with Zoladex by subcutaneous injection,and the experimental group were additionally treated with Zoladex by subcutaneous injection combined with flexion progesterone and estradiol valerate by oral.The pain degrees of the pelvic pain,dyspareunia and dysmenorrhea were evaluated before and after treatment.The serum levels of estrogen(E2),LH and follicle stimulating hormone(FSH) at different time-points were measured.The incidence rate of insomnia,libido and bone pain in two groups were evaluated after treatment.Results:Before treatment,the differences of the scores of pelvic pain,dyspareunia and dysmenorrhea,and serum levels of E2,LH and FSH between two groups were not statistically significant(P>0.05).After treatment,the scores of pelvic pain and dyspareunia,and its pain degree in two groups significantly decreased compared before treatment(P<0.01),and the serum levels of LH and FSH were significantly lower than those before treatment(P<0.01).After treatment,the differences of the incidence rates of the insomnia,night sweat,sexual desire drop between two groups were not statistically significant(P>0.05),but the incidence rates of hectic fever,mood swing and bone pain in experimental group were significantly lower than those in control group(P<0.05).Conclusions:The GnRHa combined with hormone in the treatment of endometriosis can maintain the normal level of estrogen,improve menopausal symptoms and relieve pain,and which is worthy of clinical promotion.
2018, 43(12): 1625-1627.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.025
Abstract:
Objective:To understand the correlations among the loneliness,social support and quality of life in community elderly.Methods:The elderly over 60 years old in Bengbu community were investigated using the SF-12 quality of life scale,UCLA loneliness scale and social support scale.Results:The actual scores of social support in community elderly ranged from 16 to 53 points,and the average score of which was(33.6±7.9).The loneliness score of the elderly was(43.53±3.776).The highest and lowest dimensions of the quality of life scores were physiological function and bodily pain,respectively.The correlation coefficient among three was from -0.332 to 0.126(P<0.05 to P<0.01).The social support played a part of the mediate function between loneliness and quality of life in elderly.Conclusions:To promote the quality of life,we should not only pay attention to the loneliness,but also pay attention to the social support status of the community elderly.Taking long-term measure to improve the social support level is an important way to improve the quality of life of the elderly.
Objective:To understand the correlations among the loneliness,social support and quality of life in community elderly.Methods:The elderly over 60 years old in Bengbu community were investigated using the SF-12 quality of life scale,UCLA loneliness scale and social support scale.Results:The actual scores of social support in community elderly ranged from 16 to 53 points,and the average score of which was(33.6±7.9).The loneliness score of the elderly was(43.53±3.776).The highest and lowest dimensions of the quality of life scores were physiological function and bodily pain,respectively.The correlation coefficient among three was from -0.332 to 0.126(P<0.05 to P<0.01).The social support played a part of the mediate function between loneliness and quality of life in elderly.Conclusions:To promote the quality of life,we should not only pay attention to the loneliness,but also pay attention to the social support status of the community elderly.Taking long-term measure to improve the social support level is an important way to improve the quality of life of the elderly.
2018, 43(12): 1628-1633.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.026
Abstract:
Objective:To explore the work burnout of counselors in medical college,and analyze the differences among different variables in three dimensions of emotional depletion,cynicism,and low achievement.Methods:Three hundred and seventy-eight on-the-job counselors from 10 medical colleges in Anhui,Jiangsu and Zhejiang provinces were investigated using Maslach et al made,Lichaoping revised MBI-GS(Maach Burnout Invent-General Survey) job burnout scale.Results:Job burnout of counselors in medical colleges was moderate.The differences of three dimensions of job burnout in different ages,genders,working years and grades counselors were statistically significant(P<0.01),and the score of cynicism increased with the increasing of age.The scores of emotional exhaustion,cynicism and reduced personal accomplishment in female counselors were higher than those in male counselors(P<0.01),the scores of emotional exhaustion in counselors with 5 to 10 years working age were significantly higher than those in other working ages group(P<0.01),and the emotional exhaustion score in less than 3 years group was lower than that in 3 to <5 years group(P<0.01).The scores of reduced personal accomplishment in working years < 3 group,3 to <5 years group and 5 to 10 years group gradually decreased in turn(P<0.05 to P<0.01).With the increasing of rank,the emotional exhaustion score gradually decreased(P<0.05 to P<0.01).The score of cynicism in deputy level counselors was higher than those in clerical and professional counselors(P<0.01 and P<0.05).The scores of emotional exhaustion in doctor,master and undergraduate medical college counselors gradually decreased in turn,and the difference of which was statistically significant(P<0.01),there was no statistical significance in the score of cynical dimensions(P>0.05),and the scores of reduced personal accomplishment in doctorate,master degree and undergraduate degree counselors gradually increased in turn(P<0.01).Conclusions:The work burnout of medical college counselors is moderate,and the difference in different variables has theoretical guiding significance in the construction of medical college counselors,professional construction,and physical and mental health development of medical college counselors.
Objective:To explore the work burnout of counselors in medical college,and analyze the differences among different variables in three dimensions of emotional depletion,cynicism,and low achievement.Methods:Three hundred and seventy-eight on-the-job counselors from 10 medical colleges in Anhui,Jiangsu and Zhejiang provinces were investigated using Maslach et al made,Lichaoping revised MBI-GS(Maach Burnout Invent-General Survey) job burnout scale.Results:Job burnout of counselors in medical colleges was moderate.The differences of three dimensions of job burnout in different ages,genders,working years and grades counselors were statistically significant(P<0.01),and the score of cynicism increased with the increasing of age.The scores of emotional exhaustion,cynicism and reduced personal accomplishment in female counselors were higher than those in male counselors(P<0.01),the scores of emotional exhaustion in counselors with 5 to 10 years working age were significantly higher than those in other working ages group(P<0.01),and the emotional exhaustion score in less than 3 years group was lower than that in 3 to <5 years group(P<0.01).The scores of reduced personal accomplishment in working years < 3 group,3 to <5 years group and 5 to 10 years group gradually decreased in turn(P<0.05 to P<0.01).With the increasing of rank,the emotional exhaustion score gradually decreased(P<0.05 to P<0.01).The score of cynicism in deputy level counselors was higher than those in clerical and professional counselors(P<0.01 and P<0.05).The scores of emotional exhaustion in doctor,master and undergraduate medical college counselors gradually decreased in turn,and the difference of which was statistically significant(P<0.01),there was no statistical significance in the score of cynical dimensions(P>0.05),and the scores of reduced personal accomplishment in doctorate,master degree and undergraduate degree counselors gradually increased in turn(P<0.01).Conclusions:The work burnout of medical college counselors is moderate,and the difference in different variables has theoretical guiding significance in the construction of medical college counselors,professional construction,and physical and mental health development of medical college counselors.
2018, 43(12): 1634-1636.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.027
Abstract:
Objective:To analyze the clinical significance of the abdominal and transvaginal color Doppler ultrasound in the diagnosis of early ectopic pregnancy.Methods:Sixty ectopic pregnancy patients were examined by the transvaginal and abdominal color Doppler ultrasound,the results of ultrasound examination were analyzed,and the detection rate of the early ectopic pregnancy between two kinds of imaging methods was compared.Results:Among 60 patients with ectopic pregnancy,the correct diagnosis and misdiagnosis rates of transabdominal color Doppler ultrasound and transvaginal color Doppler ultrasound were 75.0%,25.0% and 86.7%,13.3%,respectively,and the difference of which between two kinds of methods was statistically significant(P<0.05).The mass detection rates in ovary and oviduct of transabdominal color Doppler ultrasound and transvaginal color Doppler ultrasound were 73.3% and 90.0%,respectively,and the difference of which between two kinds of methods was statistically significant(P<0.01).Conclusions:The transvaginal color Doppler ultrasound in the diagnosis of early ectopic pregnancy has good imaging diagnostic value in clinic.
Objective:To analyze the clinical significance of the abdominal and transvaginal color Doppler ultrasound in the diagnosis of early ectopic pregnancy.Methods:Sixty ectopic pregnancy patients were examined by the transvaginal and abdominal color Doppler ultrasound,the results of ultrasound examination were analyzed,and the detection rate of the early ectopic pregnancy between two kinds of imaging methods was compared.Results:Among 60 patients with ectopic pregnancy,the correct diagnosis and misdiagnosis rates of transabdominal color Doppler ultrasound and transvaginal color Doppler ultrasound were 75.0%,25.0% and 86.7%,13.3%,respectively,and the difference of which between two kinds of methods was statistically significant(P<0.05).The mass detection rates in ovary and oviduct of transabdominal color Doppler ultrasound and transvaginal color Doppler ultrasound were 73.3% and 90.0%,respectively,and the difference of which between two kinds of methods was statistically significant(P<0.01).Conclusions:The transvaginal color Doppler ultrasound in the diagnosis of early ectopic pregnancy has good imaging diagnostic value in clinic.
2018, 43(12): 1636-1638.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.028
Abstract:
Objective:To investigate the value of transcranial doppler(TCD) combined with carotid artertery ultrasound in observing the hemodynamics of intracranial and extracranial blood vessels in posterior circulation ischemia(PCI) lesions,and morphological structure of carotid and vertebral artery.Methods:Forty-eight patients diagnosed by carotid artery and vertebral artery plaque(observation group) and 38 patients without symptom(control group) were examined using TCD combined with carotid ultrasound,and the intima-media thickness(IMT),plaque number composition,diameter and blood flow dynamics characteristics were measured in two groups.Results:Compared with the control group,the IMT of carotid and vertebral artery in observation group thickened(P<0.01).Compared with the control group,the intimal surface was rough,the number of plaques were 46,and the average blood flow rate decreased in observation group(P<0.01).The pulsation and resistance indexes in observation group increased compared with the control group(P<0.01).Conclusions:The application of TCD combined with carotid ultrasound can understand the blood supply of extracranial and intracranial vessels,and which has important clinical value in the etiology diagnosis,guiding treatment and observing curative effect.
Objective:To investigate the value of transcranial doppler(TCD) combined with carotid artertery ultrasound in observing the hemodynamics of intracranial and extracranial blood vessels in posterior circulation ischemia(PCI) lesions,and morphological structure of carotid and vertebral artery.Methods:Forty-eight patients diagnosed by carotid artery and vertebral artery plaque(observation group) and 38 patients without symptom(control group) were examined using TCD combined with carotid ultrasound,and the intima-media thickness(IMT),plaque number composition,diameter and blood flow dynamics characteristics were measured in two groups.Results:Compared with the control group,the IMT of carotid and vertebral artery in observation group thickened(P<0.01).Compared with the control group,the intimal surface was rough,the number of plaques were 46,and the average blood flow rate decreased in observation group(P<0.01).The pulsation and resistance indexes in observation group increased compared with the control group(P<0.01).Conclusions:The application of TCD combined with carotid ultrasound can understand the blood supply of extracranial and intracranial vessels,and which has important clinical value in the etiology diagnosis,guiding treatment and observing curative effect.
2018, 43(12): 1642-1644,1648.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.030
Abstract:
Objective:To explore the effects of Beck's cognitive therapy on treatment compliance of patients with bone metastases.Methods:A total of 204 patients with bone metastases were randomly divided into the observation group and control group.The control group was treated with suiting the case,and the observation group was treated with Beck's cognitive therapy based on the control group.The psychologic status in two groups was evaluated using the NRS,HAMD and HAMA scales before and after treatment.Results:The differences of the scores of NRS,HAMD and HAMA between two groups before treatment were not statistically significant(P>0.05).After treatment,the scores of NRS,HAMD and HAMA in observation group were lower than those in control group(P<0.01).After Beck's cognitive therapy intervention,the difference of drug use between two groups was not statistically significant(P>0.05).The timely next week treatment,designated movement and satisfaction in observation group were better than those in control group(P<0.05 to P<0.01).Conclusions:The Beck's cognitive therapy can obviously improve pain,mental state,treatment compliance and life quality of patients with bone metastases,and is worthy of popularization and application in clinic.
Objective:To explore the effects of Beck's cognitive therapy on treatment compliance of patients with bone metastases.Methods:A total of 204 patients with bone metastases were randomly divided into the observation group and control group.The control group was treated with suiting the case,and the observation group was treated with Beck's cognitive therapy based on the control group.The psychologic status in two groups was evaluated using the NRS,HAMD and HAMA scales before and after treatment.Results:The differences of the scores of NRS,HAMD and HAMA between two groups before treatment were not statistically significant(P>0.05).After treatment,the scores of NRS,HAMD and HAMA in observation group were lower than those in control group(P<0.01).After Beck's cognitive therapy intervention,the difference of drug use between two groups was not statistically significant(P>0.05).The timely next week treatment,designated movement and satisfaction in observation group were better than those in control group(P<0.05 to P<0.01).Conclusions:The Beck's cognitive therapy can obviously improve pain,mental state,treatment compliance and life quality of patients with bone metastases,and is worthy of popularization and application in clinic.
2018, 43(12): 1645-1648.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.031
Abstract:
Objective:To explore the effects of authorized education combined with family support on the self-care ability and compliance behavior in patients with acute myocardial infarction(AMI) during convalescence.Methods:Eighty-four patients with AMI during convalescence were divided into the observation group(n=42) and control group(n=42) according to the random number table.The control group was nursed with routine method,and the observation group was nursed with authorized education combined with family support based on control group.The levels of self-care ability,compliance behavior,quality of life in two groups were evaluated using self-care ability(ESCA) scale,compliance behavior questionnaire and angina pectoris quality of life scale(SAQ) before and after intervention.Results:The differences of the self-care ability and each dimension scores between two groups before intervention were not statistically significant(P>0.05).After intervention,the self-care ability and each dimension scores in two groups were improved(P<0.05 to P<0.01),and which in observation group was significantly higher than that in control group(P<0.01).After intervention,the compliance behavior rate(including reasonable diet,timely medication,suitable exercise,regular checking,giving up smoking and limiting alcohol) in observation group was significantly higher than that in control group(P<0.01).The differences of the SAQ and each dimension scores between two groups before intervention were not statistically significant(P>0.05).After intervention,the SAQ and each dimension scores in two groups were improved(P<0.05 to P<0.01),and which in observation group was significantly higher than that in control group(P<0.01).Conclusions:Authorized education combined with family support can effectively improve the self-care ability and compliance behavior of AMI patients,so as to improve the quality of life of patients.
Objective:To explore the effects of authorized education combined with family support on the self-care ability and compliance behavior in patients with acute myocardial infarction(AMI) during convalescence.Methods:Eighty-four patients with AMI during convalescence were divided into the observation group(n=42) and control group(n=42) according to the random number table.The control group was nursed with routine method,and the observation group was nursed with authorized education combined with family support based on control group.The levels of self-care ability,compliance behavior,quality of life in two groups were evaluated using self-care ability(ESCA) scale,compliance behavior questionnaire and angina pectoris quality of life scale(SAQ) before and after intervention.Results:The differences of the self-care ability and each dimension scores between two groups before intervention were not statistically significant(P>0.05).After intervention,the self-care ability and each dimension scores in two groups were improved(P<0.05 to P<0.01),and which in observation group was significantly higher than that in control group(P<0.01).After intervention,the compliance behavior rate(including reasonable diet,timely medication,suitable exercise,regular checking,giving up smoking and limiting alcohol) in observation group was significantly higher than that in control group(P<0.01).The differences of the SAQ and each dimension scores between two groups before intervention were not statistically significant(P>0.05).After intervention,the SAQ and each dimension scores in two groups were improved(P<0.05 to P<0.01),and which in observation group was significantly higher than that in control group(P<0.01).Conclusions:Authorized education combined with family support can effectively improve the self-care ability and compliance behavior of AMI patients,so as to improve the quality of life of patients.
2018, 43(12): 1649-1652.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.032
Abstract:
Objective:To investigate the effects of group lifestyle transitional care on the quality of life and self-efficacy in cervical cancer patients.Methods:Forty-five cervical cancer patients treated with comprehensive method from August 2013 to December 2014 were nursed with routine care(control group).Forty-five cervical cancer patients treated with comprehensive method from January 2015 to December 2015 were nursed with group lifestyle transitional care based on the routine care(observation group).The scores of the quality of life scale and self-efficacy scale between two groups were compared.Results:There was no statistical significance in the scores of physical function,role function,and shortness of breath between two groups(P>0.05),and the score of quality of life in observation group was significantly better than that in control group(P<0.05 to P<0.01).Before the intervention,the difference in the score of self-efficacy between two groups was not statistically significant(P>0.05).After the intervention,the score of self-efficacy in observation group was significantly higher than before intervention(P<0.01),and the difference of the score of self-efficacy in control group between before and after intervention was not statistically significant(P>0.05).Conclusions:The group lifestyle transitional care can significantly improve the quality of life,self-efficacy and self-management in cervical cancer patients,which plays a very active role on the prognosis of patients.
Objective:To investigate the effects of group lifestyle transitional care on the quality of life and self-efficacy in cervical cancer patients.Methods:Forty-five cervical cancer patients treated with comprehensive method from August 2013 to December 2014 were nursed with routine care(control group).Forty-five cervical cancer patients treated with comprehensive method from January 2015 to December 2015 were nursed with group lifestyle transitional care based on the routine care(observation group).The scores of the quality of life scale and self-efficacy scale between two groups were compared.Results:There was no statistical significance in the scores of physical function,role function,and shortness of breath between two groups(P>0.05),and the score of quality of life in observation group was significantly better than that in control group(P<0.05 to P<0.01).Before the intervention,the difference in the score of self-efficacy between two groups was not statistically significant(P>0.05).After the intervention,the score of self-efficacy in observation group was significantly higher than before intervention(P<0.01),and the difference of the score of self-efficacy in control group between before and after intervention was not statistically significant(P>0.05).Conclusions:The group lifestyle transitional care can significantly improve the quality of life,self-efficacy and self-management in cervical cancer patients,which plays a very active role on the prognosis of patients.
2018, 43(12): 1653-1656.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.033
Abstract:
Objective:To explore the status quo of job burnout and its correlation with doctor-patient relationship of medical staff in Longhua new district.Methods:The status quo of job burnout of 500 medical staffs in Longhua new district was investigated,and assessed using the job burnout scale(MBI-SS).The dimension score of job burnout among different demographic characteristics was compared,and the medical staffs were divided into the job burnout group and normal group according to the job burnout score.The correlation between job burnout and doctor-patient relationship was analyzed using the doctor-patient relationship scale(DDPRQ-10).Results:The total score of job burnout of 49.2% of medical staffs was higher than the critical value.The scores of emotional exhaustion and cynicism were slightly higher than the critical value,and the score of low achievement was slightly lower than the critical value.The different sex,age,work age and type of work were related to the job burnout of medical staffs(P<0.05 to P<0.01).In the job burnout group,the scores of the three dimensions(the objective behavior of patients and family member,subjective feeling of medical personnel and combined of objective behavior with subjective feeling) and total doctor-patient relationship significantly decreased compared with the normal group(P<0.01).Pearson correlation analysis showed that the scores of three dimensions of job burnout were positively correlated with the scores of three dimensions of doctor-patient relationship(P<0.05).Conclusions:Strengthening the ideological education of the medical staffs,relieving the boredom in the work,and regulating the behavior of patients and their families are the most important task in solving the job burnout of medical staffs,and building a harmonious relationship between doctor and patient.
Objective:To explore the status quo of job burnout and its correlation with doctor-patient relationship of medical staff in Longhua new district.Methods:The status quo of job burnout of 500 medical staffs in Longhua new district was investigated,and assessed using the job burnout scale(MBI-SS).The dimension score of job burnout among different demographic characteristics was compared,and the medical staffs were divided into the job burnout group and normal group according to the job burnout score.The correlation between job burnout and doctor-patient relationship was analyzed using the doctor-patient relationship scale(DDPRQ-10).Results:The total score of job burnout of 49.2% of medical staffs was higher than the critical value.The scores of emotional exhaustion and cynicism were slightly higher than the critical value,and the score of low achievement was slightly lower than the critical value.The different sex,age,work age and type of work were related to the job burnout of medical staffs(P<0.05 to P<0.01).In the job burnout group,the scores of the three dimensions(the objective behavior of patients and family member,subjective feeling of medical personnel and combined of objective behavior with subjective feeling) and total doctor-patient relationship significantly decreased compared with the normal group(P<0.01).Pearson correlation analysis showed that the scores of three dimensions of job burnout were positively correlated with the scores of three dimensions of doctor-patient relationship(P<0.05).Conclusions:Strengthening the ideological education of the medical staffs,relieving the boredom in the work,and regulating the behavior of patients and their families are the most important task in solving the job burnout of medical staffs,and building a harmonious relationship between doctor and patient.
2018, 43(12): 1669-1673.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.039
Abstract:
Objective:To investigate the current situation of medical student's law education and legal awareness under the background of the current doctor-patient relationship,analyze its influencing factors,and put forward the reasonable suggestion.Methods:The cluster sampling and stratified sampling were employed,420 medical students from Anhui Medical University,Wannan Medical College,Bengbu Medical college and Anhui University of Chinese Medicine were investigated using the self-designed questionnaire.Results:A total of 420 questionnaires were issued,and 406 valid questionnaires were regained,and the effective regaining rate was 96.67%.The investigation results showed that the mastering legal basic knowledge in medical students was insufficient,the right rate of "knowing our country's legislature" was 39.55%(159/402),and the students concerning with legislation and other legal hot issues accounted for 50.49%(205/406).The main ways to learn the basic knowledge of laws and regulations in medical students were "TV,radio,newspapers,network and other media"(67.73%) and "ideological morality and legal foundation public courses"(71.43%).The administrative law was the legal knowledge that students were the most eager to understand(55.91%).The understanding degrees on the "doctor's bribery penalty","identification of medical incident" and "medical accident resolution" in clinical medicine students were significantly higher than that in non-clinical medical students(P<0.01),and the understanding degree on the "doctor's bribery penalty","identification of medical incident" and "medical accident resolution" in senior medical students were significantly higher than that in lower-grade medical students(P<0.01).There was no statistical significance in the score of understanding degree of different majors and grades medical students on "practicing physician qualification laws and regulations"(P>0.05).For law education work,59.11% medical students thought that school management did not attach importance to it.More than half of students thought that they learned little legal knowledge from course,which did not meet the need of handling the doctor-patient conflict,and 85.72% medical students thought that learning some law knowledge was vitally important during undergraduate study. Conclusions:Under the background of the current doctor-patient relationship,the law education in medical student is becoming more and more important.It requires the coordination of various aspects to improve the legal consciousness of medical students.
Objective:To investigate the current situation of medical student's law education and legal awareness under the background of the current doctor-patient relationship,analyze its influencing factors,and put forward the reasonable suggestion.Methods:The cluster sampling and stratified sampling were employed,420 medical students from Anhui Medical University,Wannan Medical College,Bengbu Medical college and Anhui University of Chinese Medicine were investigated using the self-designed questionnaire.Results:A total of 420 questionnaires were issued,and 406 valid questionnaires were regained,and the effective regaining rate was 96.67%.The investigation results showed that the mastering legal basic knowledge in medical students was insufficient,the right rate of "knowing our country's legislature" was 39.55%(159/402),and the students concerning with legislation and other legal hot issues accounted for 50.49%(205/406).The main ways to learn the basic knowledge of laws and regulations in medical students were "TV,radio,newspapers,network and other media"(67.73%) and "ideological morality and legal foundation public courses"(71.43%).The administrative law was the legal knowledge that students were the most eager to understand(55.91%).The understanding degrees on the "doctor's bribery penalty","identification of medical incident" and "medical accident resolution" in clinical medicine students were significantly higher than that in non-clinical medical students(P<0.01),and the understanding degree on the "doctor's bribery penalty","identification of medical incident" and "medical accident resolution" in senior medical students were significantly higher than that in lower-grade medical students(P<0.01).There was no statistical significance in the score of understanding degree of different majors and grades medical students on "practicing physician qualification laws and regulations"(P>0.05).For law education work,59.11% medical students thought that school management did not attach importance to it.More than half of students thought that they learned little legal knowledge from course,which did not meet the need of handling the doctor-patient conflict,and 85.72% medical students thought that learning some law knowledge was vitally important during undergraduate study. Conclusions:Under the background of the current doctor-patient relationship,the law education in medical student is becoming more and more important.It requires the coordination of various aspects to improve the legal consciousness of medical students.
2018, 43(12): 1674-1676.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.040
Abstract:
Objective:To explore the effects of flipped classroom on teaching of diagnostics experiment course.Methods:Six small classes of clinical medicine students from grade 2014 were selected,and randomly divided into the experimental group(2 classes) and control group(4 classes).The diagnostics theory course in two groups were taught using the traditional lesson method.The diagnostics experiment course in experimental group and control group were taught with traditional method and flipped classroom method,respectively.The teaching effects in two groups were evaluated using the theoretical and clinical practice skill grades.Results:The differences of the performances of theoretical course and electrocardiograph(ECG) between two groups were statistically significant(P<0.05 and P<0.01).Pearson correlation analysis showed that the score of ECG was significantly correlated with the score of diagnostics theory(P<0.05).More than 80% students thought that the flipped classroom was more acceptable,and it could improve the learning interest of diagnostics,and promote the communication between teacher and student.Conclusions:Flipped classroom can improve the good simulation environment,and enhance the learning interest and teaching effects of diagnostics course.
Objective:To explore the effects of flipped classroom on teaching of diagnostics experiment course.Methods:Six small classes of clinical medicine students from grade 2014 were selected,and randomly divided into the experimental group(2 classes) and control group(4 classes).The diagnostics theory course in two groups were taught using the traditional lesson method.The diagnostics experiment course in experimental group and control group were taught with traditional method and flipped classroom method,respectively.The teaching effects in two groups were evaluated using the theoretical and clinical practice skill grades.Results:The differences of the performances of theoretical course and electrocardiograph(ECG) between two groups were statistically significant(P<0.05 and P<0.01).Pearson correlation analysis showed that the score of ECG was significantly correlated with the score of diagnostics theory(P<0.05).More than 80% students thought that the flipped classroom was more acceptable,and it could improve the learning interest of diagnostics,and promote the communication between teacher and student.Conclusions:Flipped classroom can improve the good simulation environment,and enhance the learning interest and teaching effects of diagnostics course.
2018, 43(12): 1677-1680.
doi: 10.13898/j.cnki.issn.1000-2200.2018.12.041
Abstract:
Objective:To investigate the effects of PBL on students' self-learning ability based on child and adolescent health course,and provide the basis for improving PBL teaching design.Methods:The PBL teaching of child and adolescent health course was taught in 50 college students for three times.The students' self-learning ability was evaluated using the Students' self-evaluation questionnaire made by self.The self-learning abilities of students were divided into the general,better and best grades by teachers.The differences of students' self-learning ability among the 3 times PBL teaching were analyzed.Results:The total scores of the "ability of collecting data by several methods","abilities of language expression and organization",and "generalizing and summarizing abilities" of students in the second and third PBL teaching were higher than those in the first PBL teaching(P<0.05 to P<0.01).The scores of "ability of combining innovative idea or related life with teaching cases" in 3 groups,and "ability of collecting data by several methods" in students with better self-learning ability in the second PBL teaching were higher than those in the first and third PBL teaching(P<0.05 to P<0.01).The score of "ability of active taking part in PBL teaching" in students with better self-learning ability in the third PBL teaching was lower than that in the first and second PBL teaching(P<0.01).Conclusions:PBL teaching can improve the students' self-learning ability.The students' self-learning abilities do not increase with the increasing of PBL teaching time.The PBL teaching time and interval time should be reasonably set up.
Objective:To investigate the effects of PBL on students' self-learning ability based on child and adolescent health course,and provide the basis for improving PBL teaching design.Methods:The PBL teaching of child and adolescent health course was taught in 50 college students for three times.The students' self-learning ability was evaluated using the Students' self-evaluation questionnaire made by self.The self-learning abilities of students were divided into the general,better and best grades by teachers.The differences of students' self-learning ability among the 3 times PBL teaching were analyzed.Results:The total scores of the "ability of collecting data by several methods","abilities of language expression and organization",and "generalizing and summarizing abilities" of students in the second and third PBL teaching were higher than those in the first PBL teaching(P<0.05 to P<0.01).The scores of "ability of combining innovative idea or related life with teaching cases" in 3 groups,and "ability of collecting data by several methods" in students with better self-learning ability in the second PBL teaching were higher than those in the first and third PBL teaching(P<0.05 to P<0.01).The score of "ability of active taking part in PBL teaching" in students with better self-learning ability in the third PBL teaching was lower than that in the first and second PBL teaching(P<0.01).Conclusions:PBL teaching can improve the students' self-learning ability.The students' self-learning abilities do not increase with the increasing of PBL teaching time.The PBL teaching time and interval time should be reasonably set up.
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