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2021 Vol. 46, No. 2
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2021, 46(2): 141-145.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.001
Abstract:
ObjectiveTo investigate the effect of tetramethylpyrazine (TMP) on the permeability of human umbilical vein endothelial cells (HUVECs) induced by lipopolysaccharide (LPS) and the expression of cytoskeleton-related proteins. MethodsHUVECs cultured in vitro were randomly divide into normal control group, LPS group (1 μg/mL LPS), TMP low, medium and high dose group (60 μg/mL TMP+1 μg/mL LPS, 120 μg/mL TMP+1 μg/mL LPS, 240 μg/mL TMP+1 μg/mL LPS), pure TMP group (240 μg/mL TMP).Endothelial cell permeability model was established in Transwell chamber; cell voltage resistance meter was used to measure the trans-endothelial electrical resistance in each group; FITC-dextran method was used to detect the permeability change in each group, and Pull-Down experiment was used to collect Rac1-GTPase active protein, Western blotting was used to detect the protein expression of Rac1-GTPase, Rac1, LIMK1 and p-LIMK1 in each group. ResultsTEER and permeability coefficient showed that three different concentrations of TMP inhibited the decrease of TEER induced by LPS in endothelial cells and decreased LPS-induced endothelial cell permeability(P < 0.05 to P < 0.01);Western blotting analysis showed that TMP could effectively inhibit the LPS-induced up-regulation of Rac1-GTPase, p-LIMK1, Rac1 and LIMK1 in HUVECs(P < 0.05 to P < 0.01). ConclusionsTMP can effectively inhibit the increase of permeability of HUVECs induced by LPS, which may be related to the down-regulation of Rac1-GTPase active protein and LIMK1 phosphorylation protein expression in Rac1/LIMK1 signaling pathway.
2021, 46(2): 146-149.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.002
Abstract:
ObjectiveTo construct the stereotatic localization data set and its plane projection regression equation of the intraparietal sulcus based on the AC-PC localization system. MethodsThe transverse tomography data of 30 healthy adults were imported into the Photoshop CS software package by format transformation.After strict image registration, a three dimensional coordinate system with AC-PC midpoint as the origin was established to obtain the three-dimensional coordinate values of intraparietal sulcus in the coronal plane images of brain.The X-value and Z-value of the sample point were recorded directly from the software, and the Y-value was the product of the number of layers between the image layer and AC-PC plane, and interlayer spacing.The stereotactic localization data set of the intraparietal sulcus were constructed using all the coordinate values of sample points in intraparietal sulcus.The SPSS 22.0 software was used to calculate the obtained data, and solve the spatial fitting plane regression equation. ResultsThe data set of three-dimensional localization in three-dimensional coordinate system and its regression equation of projection on every plane of space of intraparietal sulcus were successfully constructed.On the right side of the regression equation of Z-value to X-value on the coronal plane: \begin{document}$\hat{Z} $\end{document} \begin{document}$\hat{Z} $\end{document} \begin{document}$\hat{Z} $\end{document} \begin{document}$\hat{Z} $\end{document} \begin{document}$\hat{Z} $\end{document} \begin{document}$\hat{Z} $\end{document} ConclusionsThe strereotatic localization data set of the intraparietal sulcus is expected to be of guiding significance for cortical functional area localization, lesion localization and robot precision surgery planning near the area of intraparietal sulcus.
2021, 46(2): 150-153.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.003
Abstract:
ObjectiveTo investigate the effects of BCG intervention on the airway remodeling and serum hypoxia-inducible factor-1 alpha(HIF-1α)expression in bronchial asthma rats. MethodsThirtySD rats were randomly divided into the control group, asthma group and BCG treatment group(10 rats each group).The asthma group were intraperitoneally injected with 10% egg albumin(OVA)combined with aluminum hydroxide mixture for sensitization, and then stimulated by 1% OVA ultrasonic atomization inhalation to establish bronchial asthma model.The control group were treated with the same establishing model method, but at the corresponding time point, 0.9% sodium chloride solution was used to replace the sensitizer, and intraperitoneal injection and ultrasonic atomization inhalation were performed.The modeling method in BCG treatment group were the same as that of the asthma group, and the intradermal injection of 0.025 mg of BCG before half an hour of atomization was performed daily for intervention treatment.The inter-group variables were analyzed using Pearson correlation analysis method.The serum samples were collected after 24 h of last stimulation in three groups, and the contents of HIF-1α were detected using ELISA.After the rats were sacrificed, the trachea and lung histopathology sections were made to observe the airway inflammation and tracheal remodeling.The image analysis software was used to measure the internal diameter circumference(Pi), bronchial tube wall area(WAt)and total area of bronchial smooth muscle(WAm). ResultsThe structures of alveoli, trachea and blood vessels in control group were normal.In the asthma group, the alveolar wall significantly thickened, mucus remained in the trachea cavity, and intra-alveolar hemorrhage was partially observed.The overall structure of lung tissues in BCG treatment group tended to be normal.The serum HIF-1α content in asthma group increased compared with the control group, and the serum HIF-1 content decreased after BCG intervention(P < 0.01).The HIF-1α was positively correlated with bronchial wall thickness(WAt/Pi)and bronchial smooth muscle thickness(WAm/Pi)(P < 0.01). ConclusionsAfter BCG intervention treatment, the airway remodeling alleviates in bronchial asthma rats, and the effects may be by inhibiting HIF-1α expression to play.
2021, 46(2): 154-158.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.004
Abstract:
ObjectiveTo investigate the effects of long-chain non-coding RNA PCBP1-AS1(LncRNA PCBP1-AS1)on the proliferation, invasion and apoptosis of oral squamous carcinoma cells(OSCC)cells, and its possible mechanism. MethodsThe expression level of PCBP1-AS1 in OSCC cells was detected using Real-time quantitative polymerase chain reaction(qRT-PCR).The pcDNA-PCBP1-AS and pcDNA-control were transfected into the luminal squamous cell carcinoma CAL-27 cells using Lipofectamine 2000.The proliferation ability, invasive ability and apoptotic rate of CAL-27 cells were detected using MTT assay, Transwell experiments and flow cytometry, respectively. ResultsCompared with the normal oral epithelial cells, the expression levels of PCBP1-AS1 in oral squamous cell carcinoma cells CAL-27, Tca8113, and KB significantly decreased(P < 0.01).The overexpression of PCBP1-AS1 could significantly inhibit the proliferation and invasion of CAL-27 cells(P < 0.01), and promote apoptosis of cells(P < 0.01).The overexpression of PCBP1-AS1 could significantly inhibit the protein expression levels of CDK1, MMP-2, Bcl2, p-JAK2 and p-STAT3(P < 0.01), and promote the protein expression of Bax(P < 0.01). ConclusionsThe overexpression of PCBP1-AS1 can inhibit the proliferation and invasion of OSCC cells, and induce its apoptosis, and the mechanism of which may be related to the inhibition of JAK2/STAT3 signaling pathway activation.
2021, 46(2): 159-161.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.005
Abstract:
ObjectiveTo investigate the effects of Ⅱ, Ⅲ degree acid/base burns on ocular surface. MethodsThe patients with Ⅱ and Ⅲ degree acid/base burns were divided into the acid burn group(n=20, 31 eyes)and base burn group(n=22, 30 eyes), and 21 eyes without burn were set as the normal group.The tear-film break-up time(BUT), Schirmer Ⅰ test, surface regularity index(SRI), and surface symmetry index(SAI)and cylinder(CYL)of cornea were collected. ResultsThe BUT in acid burn group and base burn group was significantly lower than that in normal group(P < 0.01), and the difference of BUT between the acid burn group and base burn group was not statistically significant(P>0.05).The differences of the Schirmer Ⅰ, SRI, SAI and CYL among three groups were not statistically significant(P>0.05). ConclusionsThe Ⅱ, Ⅲ degree acid/base burns do not affect the tear's secretion, but affect the tear-film stability.
2021, 46(2): 162-165.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.006
Abstract:
ObjectiveTo evaluate the application value of dexmedetomidine under SEDline sedation monitoring in thoracoscopic lobectomy in order to provide a more safe and effective method for anesthesia. MethodsA total of 20 ASA Ⅰ or Ⅱ patients treated with thoracoscopic lobectomy were randomly divided into the dexmedetomidine group(group D)and control group(group N)(10 cases in each group).The MAP, HR, SpO2 and PSI in two groups before anesthesia induction(T0), during skin incision(T1), after 30 minutes of one lung ventilation(T2)and immediately after surgery(T3)were recorded.The dosage of remifentanil and propofol, and scores of VAS and Ramsay after 6 h and 24 h of operation were recorded. ResultsThe MAP, HR and PSI in two groups at T1, T2 and T3 decreased(P < 0.01), the decreasing degree of MAP in group N was more obvious compared with the group D at T2(P < 0.01), the HR in group D at T1was significantly lower than that in group N(P < 0.01), and the PSI in group D was lower than that in group N at T2(P < 0.01).The dosage of remifentanil and propofol in group D were significantly lower than these in group N.The scores of VAS and Ramsay in group D were lower and higher than that in group N after 6 h of operation, respectively(P < 0.01). ConclusionsThe dexmedetomidine under SEDline sedation monitoring in patients treated with thoracoscopic lobectomy can control the patient's anesthetic state, maintain the hemodynamics, improve the postoperative sedation and analgesia, and have no postoperative agitation, which can plays certain positive roles in the patient's quick recovery.
2021, 46(2): 166-169.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.007
Abstract:
ObjectiveTo investigate the significance of magnetic sensitive weighted imaging(SVS)in the diagnosis and treatment of acute cerebral infarction. MethodsThe routine detection of MRI, DWI, SWI and MRA in 25 patients with acute cerebral infarction were implemented.The location of intracranial responsible blood vessel thrombosis was analyzed using SWI, the nerve defect degree score on admission and disability score after 90 days of onset were performed in all cases, and the significance of magnetically sensitive thrombus sign in judging the prognosis of patients was analyzed. ResultsAmong 25 patients with acute cerebral infarction, the SVS along lesion vessel in 17 cases(68%)were found in SWI, and the vascular occlusion rate in SVS-positive patients was higher than that in SVS-negative patients(P < 0.05).During the following-up for 90 days of 25 patients with cerebral infarction, the clinical prognosis in 10 cases with positive SVS, 8 cases with negative SVS and 1 case were poor, and the poor clinical prognosis rate of positive SVS patients in SWI was higher compared with negative SVS patients(P < 0.05). ConclusionsDuring the acute phase of cerebral infarction, the SVS sign in SWI can indicate the intracranial responsible intra-arterial thrombosis, and poor clinical prognosis.
2021, 46(2): 169-172.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.008
Abstract:
ObjectiveTo detect the expression levels of Golgi phosphoprotein 3(GOLPH3)and vascular endothelial growth factor(VEGF)in cervical cancer tissues, and explore their relationship in invasion and metastasis of cervical cancer. MethodsThe expression levels of GOLPH3 and VEGF proteins in cervical carcinoma tissues and para-cervical cancer tissues of 43 patients were detected using immunohistochemical SP method.The correlations of GOLPH3 and VEGF levels in cervical cancer tissues were analyzed using Pearson correlation analysis. ResultsThe positive expression rates of GOLPH3 and VEGF in cervicer cancer tissues were 72.1% and 74.42%, respectively, which were significantly higher than those in para-cervical cancer tissues(37.21% and 32.56%)(P < 0.01).The expression levels of GOLPH3 and VEGF in cervical cancer tissue were significantly correlated with the tumor size, differentiation, surgical and pathological stage, and lymph node metastasis(P < 0.05 to P < 0.01), and not significantly correlated with the age and pathological type of patients(P>0.05).The results of immunohistochemistry showed that the positive expression rate of VEGF in cervical cancer tissues with positive GOLPH3 expression group(83.87%)was significantly higher than that in negative GOLPH3 expression group(33.33%)(P < 0.01).The expression rate of GOLPH3 was positively correlated with VEGF expression in cervical cancer tissues(r=0.494, P < 0.01). ConclusionsThe overexpression of GOLPH3 promotes the angiogenesis in cervical cancer tissues by upregulating the expression of VEGF, which leads to the invasion and metastasis of cervical cancer.
2021, 46(2): 173-175, 178.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.009
Abstract:
ObjectiveTo compare the curative effects between transaxillary approach non-inflatable total cavity endoscopy and open radical thyroidectomy in the treatment of stage cN0 thyroid papillary microcarcinoma. MethodsThe clinicopathological data of 60 cases with stage cN0 thyroid papillary microcarcinoma were retrospectively analyzed.Thirty cases were treated with transaxillary approach non-inflatable total cavity endoscopy radical thyroidectomy(observation group), and 30 cases were treated with transaxillary approach open radical thyroidectomy(control group).The clinical efficacy was compared between two groups. ResultsThe differences of the number of lymph node dissection and positive number of lymph node metastasis in central region, and incidence rate of total complications were not statistically significant(P>0.05).The operative time, total amount of drainage fluid and length of hospital stay in observation group were more than those in control group, the intraoperative blood loss in observation group was less than that in control group, and the neck and chest pain score and aesthetic satisfaction in observation group were better than those in control group(P < 0.01). ConclusionsCompared with open radical thyroidectomy, the transaxillary approach non-inflatable total cavity endoscopy radical thyroidectomy can guarantee the safety of surgery, reduce postoperative pain and greatly improve aesthetic satisfaction.
2021, 46(2): 176-178.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.010
Abstract:
ObjectiveTo investigate the correlations of the serum levels of Caspase-3 and Caspase-9 with clinical phenotypes in chronic obstructive pulmonary disease(COPD)elderly patients complicated with snoring syndrome. MethodsThree hundred and twelve elderly patients with COPD were divided into the snoring group and simple group according to the presence or absence of snoring syndrome.The serum levels of Caspase-3 and Caspase-9 were compared between two groups, and the relationships between serum levels of Caspase-3, Caspase-9 and sleep index in COPD elderly patients complicated with snoring syndrome were analyzed. ResultsThe serum levels of Caspase-3 and Caspase-9 in snoring group were significantly higher than those in simple group(P < 0.01).The AHI and ODI in snoring group were significantly positively correlated with the serum levels of Caspase-3 and Caspase-9, and the LSaO2 and MSaO2 were negatively correlated with the serum levels of Caspase-3 and Caspase-9(P < 0.01). ConclusionsThe high serum levels of Caspase-3 and Caspase-9 are correlated with the low degree of APNEA in elderly COPD patients complicated with snoring syndrome.The higher the serum levels of Caspase-3 and Caspase-9 are, the more severe of sleep disturbance is.
2021, 46(2): 179-182.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.011
Abstract:
ObjectiveTo investigate the relationship between periodontitis and gestational diabetes mellitus(GDM) in nonsmoking women for providing theoretic basis in treating and preventing this disease. MethodsThe total periodontal examination was performed on 250 GDM women(GDM group) and 250 normal pregnant women(control group).The periodontitis was defined as the presence of ≥5 mm probing depth(PD) at ≥1 site in the mouth and loss of clinical periodontal attachment(CAL) at the same site ≥2 mm.The expression levels of C reactive protein(CRP), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in two groups were measured in peripheral blood, and the conditional logistic regression test was used to analyze the results. ResultsThe family history of diabetes and prepregnancy body mass index in GDM group were higher than those in control group(P < 0.01).The percentage of PD, CAL, exploratory bleeding site and rate of periodontitis in GDM group were higher than those in control group(P < 0.05 to P < 0.01).The periodontitis and family history of diabetes were the risk factors of GDM(P < 0.01).The CRP expression level in GDM group was higher than that in control group(P < 0.01). ConclusionsThe periodontitis is associated with GDM.The clinicians should pay attention to the periodontal status of pregnant women.
2021, 46(2): 183-186, 190.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.012
Abstract:
ObjectiveTo study the correlations among the expression levels of human epididymal protein 4(HE4), carbohydrate antigen 199(CA199) and human lysophosphatidic acid(LPA) in ovarian cancer, and its clinicopathological features. MethodsOne hundred and forty patients with ovarian cancer, 120 ovarian benign lesions patients treated with operation and 100 healthy women were divided into the ovarian cancer group, ovarian benign lesion group and healthy control group, respectively.The expression levels of HE4, CA199 and LPA in three groups were detected, the positive expression of HE4, CA199 and LPA between ovarian benign lesion group and ovarian cancer group were compared.The correlation of the HE4, CA199 and LPA with clinicopathological characteristics of ovarian cancer patients, and correlation among the expression of HE4, CA199 and LPA were analyzed. ResultsThe serum levels of HE4, CA199 and plasma LPA in ovarian cancer group were higher than those in benign ovarian lesion group and healthy control group(P < 0.05), and the positive rates of HE4, CA199 and LPA in ovarian cancer group were higher than those in benign ovarian lesion group(P < 0.01).The expression levels of HE4, CA199 and LPA were not correlated with the pathological type and diameter of ovarian cancer(P>0.05), but which were related to the clinical stage, differentiation degree and lymph node metastasis of ovarian cancer patients(P < 0.01).The expression levels of HE4, CA199 and LPA in patients with stage Ⅲ-Ⅳ, low differentiation and lymph node metastasis were higher.The HE4 level was positively correlated with CA199(r=0.183, P < 0.05), the HE4 level was positively correlated with LPA(r=0.216, P < 0.05), and the CA199 level was positively correlated with LPA(r=0.209, P < 0.05). ConclusionsThe expression levels of HE4, CA199 and LPA in ovarian cancer patients are high, which are related to the clinical stage, differentiation degree and lymph node metastasis.
2021, 46(2): 187-190.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.013
Abstract:
ObjectiveTo explore the curative effects of manual therapy combined with electric traction in the treatment of cervical spondylotic radiculopathy(CSR). MethodsEighty-eight patients with CSR were randomly divided into the observation group and control group using number table method(44 cases in each group).The control group was treated with conventional electric traction, and the observation group was treated with Mulligan manual therapy based on the control group for 4 weeks.The pain visual analogue(VAS)score, neck disability index(NDI)and clinical assessment scale cervical spondylosis(CASCS)score in two groups were compared between before and after treatment.The right and left rotation angles of the cervical spine in two groups were measured before and after treatment.The comprehensive curative effects in two groups after 4 weeks of treatment were evaluated. ResultsAfter treatment, the CASCS score significantly increased, and the VAS score and NDI significantly decreased in two groups(P < 0.01).After treatment, the CASCS score in observation group was higher than that in control group, and the VAS score and NDI in observation group were significantly lower than those in control group(P < 0.01).After treatment, the right and left rotation angles of the cervical spine in two groups significantly increased, and the right and left rotation angles in observation group were significantly larger than those in control group(P < 0.01).The total effective rates in the observation group and control group were 95.45% and 81.82%, respectively, but and the difference of which was not statistically significant(P>0.05). ConclusionsThe Mulligan technique manual therapy based on traditional electric traction for CSR can effectively improve the pain, dizziness and dysfunction, and improve cervical vertebra activity.This method is quick and easy to operate, and suitable for physical therapy of CSR.
2021, 46(2): 191-194.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.014
Abstract:
ObjectiveTo investigate the correlations of self-management behavior with self-efficacy and quality of life in patients with ankylosing spondylitis(AS)complicated with cervical spine fracture. MethodsA total of 144 AS patients were divided into the observation group(44 cases with cervical spine fractures)and control group(100 cases without cervical spine fractures).The self-efficacy, self-management behavior and quality of life in two groups were evaluated using the Anderson Self-Efficacy Scale(CPSS), Bath AS Functional Index(BASFI)and World Health Organization Quality of Life Scale Shortlist(WHOQOL-BREF), respectively.The correlations of self-management behavior with self-efficacy and quality of life in observation group were analyzed. ResultsThe scores of the pain management, physical function and symptom response in self-efficacy, and scores of self-health assessment, living environment, mental state, physiological function and social relationship scores in quality of life in observation group were significantly lower than those in control group(P < 0.01), and the management behavior score in observation group was also lower than that in control group(P < 0.01).The results of linear correlation analysis showed that the scores of self-efficacy dimensions were positively correlated with the scores of self-management behavior and quality of life in patients with AS complicated cervical fractures(P < 0.05). ConclusionsThe level of self-efficacy of AS patients complicated with cervical spine fractures decreases, so the self-management needs to be strengtheneds to improve the quality of life of patients.
2021, 46(2): 194-197.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.015
Abstract:
ObjectiveTo explore the analgesic effects of different doses of oxycodone on transabdominal myomectomy and its effect on stress response. MethodsOne hundred and twenty-eight patients with transabdominal myomectomy were divided into the group A(treated with 0.05 mg/kg of oxycodone), group B(treated with 0.10 mg/kg of oxycodone), group C(treated with 0.15 mg/kg of oxycodone)and group O(treated with 0.001 mg/kg of fentanyl)according to the dose of oxycodone(32 cases in each group).The visual analogue scale(VAS)score, restlessness and sedation scale(RASS)score, blood glucose and cortisol levels, and incidence rate of adverse reactions were compared among 4 groups. ResultsThe VAS scores of group A at T2 and T4, group B at T2 and T3, and group C at T2 to T4 were lower than those of three groups at T1(P < 0.05 to P < 0.01).The RASS scores of group A, group B, group C and group O at T2 to T4 were significantly increased compared with those at T1(P < 0.01).The VAS scores in group A, group B and group C at T1 and T2 were significantly lower than those in group O(P < 0.01), and the RASS scores in group A, group B and group C at T1 were significantly lower than those in group O(P < 0.01).The VAS scores in group B and group C at T1 to T3 were significantly lower than those in group A(P < 0.01), and the RASS score in group C at T1 was significantly lower than that in group A(P < 0.01).The VAS and RASS scores in group C at T1 were lower than those in B group(P < 0.05 and P < 0.01).The blood glucose levels in group A at T2 to T4, group B at T2 to T4 and group O at T1 to T4 were significantly higher than those at T0(P < 0.05 to P < 0.01).The levels of cortisol in A, B, C and O groups at T1 to T4 significantly increased compared with at T0(P < 0.01).The blood glucose and cortisol levels in group A, group B and group C at T1 to T3 were lower than those in group O(P < 0.05 to P < 0.01).The incidence rate of total adverse reactions in group C was higher than that in other 3 groups(P < 0.05). ConclusionsThe 0.10 mg/kg of oxycodone in transabdominal myomectomy has good analgesic effect, high safety, and can significantly inhibit the stress response of patients.It is worthy of popularization.
2021, 46(2): 198-201.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.016
Abstract:
ObjectiveTo investigate the value of fractional exhaled nitric oxide(FeNO)combined with pulmonary function test in the diagnosis of small airway lesions and etiology in patients with chronic cough. MethodsOne hundred and sixty-six patients with chronic cough were divided into the small airway lesion group and no small airway lesion group according to the results of pulmonary function test.The correlation between FeNO and small airway function indexes, sputum-induced EOS and IgE level in small airway lesion group were analyzed.The ROC curve was used to analyze the predictive value of FeNO level in small airway lesion patients with chronic cough.The value of FeNO in the diagnosis of chronic cough was analyzed. ResultsThe ROC curve was used to analyze small airway lesion by FeNO, the results showed that the area under the curve was 0.776, and the 95%CI was 0.720-0.832.The optimal threshold of FeNO in predicting small airway lesion was 29.0 ppb, and the corresponding sensitivity and specificity were 60.7% and 82.5%, respectively.The ROC curve of FeNO in diagnosing the CVA during chronic cough was analyzed, the results showed that the area under the curve was 0.902, and the 95% CI was 0.864-0.935.The optimal threshold of FeNO in predicting CVA was 40.1 ppb, the corresponding sensitivity and specificity were 83.3% and 86.7%, respectively. ConclusionsFeNO combined with pulmonary function test is of great value in the diagnosis of chronic cough small airway lesion.
2021, 46(2): 202-205.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.017
Abstract:
ObjectiveTo explore the clinical effect of short segment nail rod fixation combined with injured vertebral bone grafting in the treatment of unstable Kümmell disease. MethodsThe clinical data of 47 patients with unstable Kümmell disease were retrospectively analyzed.Twenty-five patients treated with short segmental nail rod fixation combined with injured vertebral bone grafting were set as the injured vertebral bone grafting group, and 22 patients treated with short segment nail rod fixation combined vertebroplasty were set as the vertebroplasty group.The surgery-related indicators between two groups were compared.The pain visual analogue(VAS)score, Cobb angle and anterior margin height ratio of injured vertebrae before surgery, after 7 days, 6 months and last following-up of operation were compared between two groups.The occurrence of complications in two groups was recorded. ResultsThe differences of the operation time, amount of bleeding and length of hospital stay between two groups were not statistically significant(P>0.05).After 7 days, 6 months and last following-up of operation, the height ratio of anterior margin in two groups were significantly higher than that before operation(P < 0.01), the VAS score and Cobb angle were significantly lower than that before surgery(P < 0.01).The 7-day VAS score in injured vertebraling bone grafting group was significantly higher than that in vertebroplasty group(P < 0.01), and the VAS scores in injured vertebral bone grafting group after 6 months and last following-up of operation were significantly lower than that in vertebroplasty group(P < 0.01).The differences of the Cobb angle and height ratio of anterior margin between two groups were not statistically significant(P>0.05).The incidence rate of complication in vertebroplasty group(31.82%)was significantly higher than that in injured vertebral bone grafting group(8.00%)(P < 0.01). ConclusionsShort segment nail rod fixation combined with injured vertebral bone grafting and vertebroplasty can effectively restore the vertebral height and physiological curvature of unstable Kümmell disease, which combined with injured vertebral bone grafting can improve the long-term pain, and decrease the incidence rate of complication.
2021, 46(2): 206-209, 213.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.018
Abstract:
ObjectiveTo analyze the clinicopathological features of breast cancer, and explore the related factors of axillary lymph node metastasis in patients with breast cancer. MethodsThe clinical data of 105 breast cancer patients treated with operation, and diagnosed by pathology, were retrospectively analyzed.The relative factors of axillary lymph node metastasis were investigated. ResultsAmong 105 patients, 45 cases with axillary lymph node metastasis were found, and the metastasis rate was 42.9%.The differences of the age, tumor length, tumor location, histological grade, pathological type, vascular cancer embolus infiltration and axillary lymph node metastasis rate in breast cancer patients were statistically significant(P < 0.05 to P < 0.01).The results of multivariate logistic analysis showed that the long tumor in length diameter and vascular cancer embolus infiltration were the independent risk factors of axillary lymph node metastasis in breast cancer(P < 0.05). ConclusionsThe length diameter of tumor size and tumor vascular invasion are the independent risk factors of axillary lymph node metastasis.
2021, 46(2): 210-213.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.019
Abstract:
ObjectiveTo investigate the expression level of miR-377 in ovarian cancer tissues, and analyze the correlation between miR-377 expression, and clinicopathological parameters and prognosis of patients. MethodsFifty ovarian cancer tissue samples and 50 normal ovarian tissue samples were divided into the ovarian cancer group and control group, respectively.The clinical pathological parameters data were collected.The expression levels of miR-377 in two groups were detected using RT-qPCR, and the relationship between mir-377 expression and relevant clinical pathological parameters in ovarian cancer patients were analyzed.The relationship between mir-377 expression and prognosis was analyzed using survival curve, and the independent risk factors of ovarian cancer prognosis using multivariate COX regression method. ResultsThe expression level of miR-377 in ovarian cancer group was significantly lower than that in control group(P < 0.01).The expression level of miR-377 in ovarian cancer group was correlated with the TNM stage, clinical stage and metastasis of tumor(P < 0.05 to P < 0.01), and not related to the age and ovarian cancer type of clinicopathological parameters(P>0.05).The 5-year survival rate of patient with low expression of miR-377(55.88%) was significantly lower than that in patients with high expression(75.00%) (P < 0.01).The results of multivariate COX regression analysis showed that the low expression of miR-377 and TNM staging were the independent risk factors of ovarian cancer prognosis(P < 0.01). ConclusionsThe expression level of miR-377 in the ovarian cancer tissues decreases significantly.The expression levels of miR-377 is related to the TNM stage, clinical stage and pathological grade of ovarian cancer, and the low expression of miR-377 and TNM stage are the independent risk factors of the prognosis of patients with ovarian cancer.
2021, 46(2): 214-217, 221.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.020
Abstract:
ObjectiveTo observe the effects of the ratio of preoperative serum C reactive protein to prealbumin(CRP/PA) on the prognosis of gastric cancer patients. MethodsThe survival and laboratory indicators in gastric cancer patients treated with radical operation were followed up and recorded.The ratio CRP to ALB and CRP/PA in all patients were calculated, the receiver operating characteristic curves(ROC)were plotted, and the area under the curve(AUC) was compared.The Youden index was calculated to obtain the optimal cutoff value of CRP/PA.The patients were divided into the high CRP/PA(HCP) group and low CRP/PA(LCP) group according to the optimal cutoff value.The clinical and pathological features, postoperative complications and prognosis in two groups were analyzed. ResultsThe ROC curves of the CRP/PA and CRP/ALB were plotted based on the 5-year survival as the end point, and the AUC of which were 0.704 and 0.656, respectively.When the CRP/PA value was 18.8×10-3, the Youden index was the largest, the sensitivity was 0.828, and the specificity was 0.562.The age, anemia, tumor diameter, infiltration depth, lymph node metastasis and TNM stage were related to the level of CRP/PA(P < 0.05 to P < 0.01).The incidence rate of complication in 214 patients was 28.9%, and which in HCP group(37.64%)was higher than that in LCP group(23.26%)(P < 0.05).Among the 214 patients with gastric cancer, 125 cases died, the 5-year cumulative survival rate of all patients was 35.5%, and the median survival time was 43 months.The 5-year cumulative survival rate in HCP group and LCP group was 29.4% and 46.3%, respectively.The 5-year survival rate in HCP group was higher than that in LCP group(P < 0.05).The results of Cox proportional hazards model showed that the level of CRP/PA and TNM stage were the independent prognostic factors for postoperative gastric cancer patients(P < 0.01). ConclusionsThe CRP/PA level and TNM stage are the independent factors affecting the prognosis of gastric cancer patients.The incidence rate of postoperative complications in patients with high CRP/PA level increases, and the prognosis of patients is poor.
2021, 46(2): 218-221.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.021
Abstract:
ObjectiveTo investigate the effects of the modified expanding suspended laminoplasty and posterior pedicle screw fixation on the perioperative indicators, postoperative neurological function and spinal stability in patients with spinal canal tumors. MethodsThe clinical data of 128 patients with spinal canal tumors were retrospectively analyzed.Seventy-five were treated with the modified expanding suspended laminoplasty(group A), and 53 cases were treated with posterior pedicle screw fixation(group B).The operative time, intraoperative blood loss and incidence rate of postoperative cerebrospinal fluid leakage, and JOA score, JOA score improvement rate and spinal instability incidence after 3, 6 and 12 months of surgery were compared between two groups. ResultsThe operative time, intraoperative blood loss and incidence rate of postoperative cerebrospinal fluid leakage in group A were significantly lower than those in group B(P < 0.05 to P < 0.01).After operation, the JOA scores in two groups significantly increased(P < 0.01).After 3, 6 and 12 of operation, the JOA score and JOA score improvement rate in group A were significantly lower than those in group B(P < 0.01), and the differences of the incidence rate of spinal instability were not statistically significant between two groups(P>0.05). ConclusionsCompared with the posterior pedicle screw fixation, the modified expanding suspended laminoplasty can shorten the operation time, and reduce the amount of intraoperative bleeding and incidence rate of cerebrospinal fluid leakage of patients with spinal canal tumors.The two types of surgery have a good effect in stabilizing the spine after operation, but the posterior pedicle screw fixation has a large amount of trauma and bleeding, and affects the mobility of the spinal fixation segment.The best choice should be chosen according to the patient's specific situation.
2021, 46(2): 222-225.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.022
Abstract:
ObjectiveTo observe the effects of arthroscopic debridement combined with sodium hyaluronate on the levels of intercellular adhesion molecule(ICAM)-1 and interleukin(IL-6)in synovial fluid and complications after treatment in patients with knee osteoarthritis. MethodsA total of 106 patients with knee osteoarthritis were randomly divided into the control group and observation group(53 cases in each group).The control group was treated with joint debridement, and the observation group was treated with joint debridement combined with sodium hyaluronate.The levels of ICAM-1 and IL-6 in synovial fluid, and complications after treatment in two groups were observed. ResultsBefore treatment, the differences of the levels of ICAM-1 and IL-6 in synovial fluid were not statistically significance between two groups(P>0.05).After treatment, the levels of ICAM-1 and IL-6 in synovial fluid in two groups significantly decreased, and the levels of ICAM-1 and IL-6 in observation group were significantly lower than those in control group(P < 0.05 and P < 0.01).Three cases with hematoma in observation group and 5 cases with hematoma in control group were found.Four cases with joint pain in observation group and 7 cases with joint pain in control group were found, and the difference of which was not statistically significant(P>0.05).Two cases with joint mobility disorder in observation group and 8 cases with joint mobility disorder in control group were found, and the difference of which was statistically significant(P < 0.05). ConclusionsArthroscopic debridement combined with sodium hyaluronate in the treatment of knee osteoarthritis can significantly improve the clinical effect, reduce the content of ICAM-1 and IL-6 in synovial fluid, and improve the prognosis of patients.
2021, 46(2): 225-227, 231.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.023
Abstract:
ObjectiveTo investigate the effects of cardiovascular disease on the glucose and lipid metabolism, insulin resistance and sex hormones in fertile women with polycystic ovarian syndrome(PCOS). MethodsThe levels of the blood glucose, insulin, blood lipid and sex hormone in 80 patients with PCOS were detected, and the patients were divided into the cardiovascular disease group(n=17)and non-cardiovascular disease group(n=63)according to the occurrence of cardiovascular disease.The levels of above-mentioned indexes, and incidence rates of abnormal glucose metabolism, dyslipidemia, insulin resistance(IR)and hyperandrogenism(HA)were compared between two groups. ResultsThe levels of postprandial 2 h blood glucose, fasting insulin, postprandial 2 h insulin, steady-state model insulin resistance index, total cholesterol, triacylglycerol, low-density lipoprotein, testosterone and sex hormone binding globulin in cardiovascular disease group were significantly higher than those in non-cardiovascular disease group(P < 0.05 to P < 0.01).The incidence rates of abnormal glucose metabolism, dyslipidemia, IR and HA in cardiovascular disease group were significantly higher than those in non-cardiovascular disease group(P < 0.05). ConclusionsThe risks of abnormal glucose and lipid metabolism, IR and HA are relatively higher in PCOS patients complicated with cardiovascular disease.
2021, 46(2): 228-231.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.024
Abstract:
ObjectiveTo investigate the infection and genotype distribution of human papilloma virus(HPV)in female cervical exfoliative cells in gynecological patients in a hospital of Bengbu, Anhui province. MethodsThe cervical exfoliated cells from 4 773 gynecological patients in the Second Affiliated Hospital of Bengbu Medical College from 2016 to 2017 were collected.Twenty-three HPV subtypes were examined using PCR reverse dotblot hybridization technique. ResultsAmong the 4 773 samples, 1 069 HPV positive cases were detected(including 943 cases of high-risk HPV, 88 cases of low-risk HPV, and 38 cases of high-low risk HPV), and the total infection rate of HPV was 22.40%.Among these positive samples, the single-subtype infection rate was 81.20%(868 cases), and the multiple-subtype infection rate was 18.80%(201 cases).HPV16(280 cases, 26.19%), HPV52(198 cases, 18.52%), HPV58(109 cases, 10.20%), HPV33(84 cases, 7.86%)and HPV56(81 cases, 7.58%)were the top five high-risk subtypes.The differences of the infection rates among different age groups were statistically significant(P < 0.01).The infection rates in age≥55 group, age < 25 group, 35>age≥25 group, 45>age≥35 group and 55>age≥45 group were 31.96%, 25.41%, 20.62%, 21.76% and 21.55%, respectively. ConclusionsThe single high-risk infection is the main type of HPV infection in gynecological patients, HPV16, HPV52 and HPV58 are the top three prevalent subtypes, and the HPV infection rate in female with age more than 55 years is higher.
2021, 46(2): 232-236.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.025
Abstract:
ObjectiveTo understand the current status of nurses' burnout and its related influencing factors, to provide a theoretical basis for alleviating nurses' burnout. MethodsUsing a convenient sampling method, a questionnaire survey was conducted on 700 nurses in 13 general hospitals including the Fourth Affiliated Hospital of Anhui Medical University and others.The influencing factors were analyzed using 2test and ordinal logistic regression. ResultsThe nurses' burnout score was(157.1±18.6)points.There were 108(15.4%)nurses with no or slight burnout, 291(41.6%)with mild to moderate burnout, and 301(43.0%)with severe burnout.Ordinal logistic regression analysis showed that the shift system of two shifts, average weekly working length of 40 to 50 hours, satisfaction with the current job, their own physical condition and poor sleep quality(sleep disturbance)were the main influencing factors of nurses' burnout. ConclusionsThe rate of nurses' burnout is high, which is related to frequent shifts, long working hours, and poor physical and sleep conditions.
2021, 46(2): 237-239.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.026
Abstract:
ObjectiveTo evaluate the effects of hepatolenticular degeneration(HLD)complicated with splenomegaly on liver hardness through real-time shear wave elastography measuring the liver shear wave velocity(SWV). MethodsThe patients with HLD were divided into two groups according to the splenomegaly.The right liver lobe SWV of patients were measured using Siemens ACUSON-OXANA3 color doppler ultrasonic diagnostic instrument with acoustic radiation force impulse imaging(ARFI), and the right liver lobe SWV values in two groups were analyzed by independent sample t test using SPSS 25.0 software. ResultsFourteen patients without splenomegaly and 24 patients with splenomegaly were identified in two groups, respectively.The difference of the SWV value of the right lobe of liver between two groups was statistically significant(P < 0.05). ConclusionsThe quantitative measurement of liver SWV velocity is helpful to timely adjust the treatment plan in the clinical treatment of patients with hepatolenticular degeneration.
2021, 46(2): 239-243.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.027
Abstract:
ObjectiveTo explore the application value of 320-detector CT isocenter scan combined with AIDR-3D reconstruction in reducing radiation dose of coronary CT angiography(CCTA). MethodsOne hundred and eight patients suspected by coronary heart disease were randomly divided into the A, B and C groups(36 cases each group).The coronary CTA scan with a tube voltage of 120 kV in all patients were implemented.The A group were scanned under traditional position, and the tube current was intelligent milliampere.The B and C groups were scanned under isocenter positions(the heart was set at the center of CT rank hole), and the tube currents were 90% and 60% of the intelligent milliampere, respectively.The Af and Aa groups in A group were obtained using the filtering back projection method and AIDR-3D reconstruction, respectively.The B and C groups were reconstructed using AIDR-3D.The signal-to-noise ratio(SNR), contrast-to-noise ratio(CNR), subjective image quality and radiation dose among Af, Aa, B and C groups were compared. ResultsThe radiation doses in A, B and C groups gradually decreased in turn(P < 0.01).The results of the subjective image quality scores in four groups showed that the score in Af group was lower than that in other three groups, and the differences of which among other three groups were not statistically significant(P>0.05).The results of the objective image quality scores in four groups showed that the noise in Af group was the highest(P < 0.01), followed by C group(P < 0.01), and which in Aa and B groups were the lowest(P < 0.01).The SNR and CNR in Aa and B groups were the highest(P < 0.01), followed by C group(P < 0.01), and whose in Af group were the lowest(P < 0.01). ConclusionsThe isocenter CT scan combined with AIDR3D can reduce the radiation dose of CCTA without reducing the quality of coronary imaging.
2021, 46(2): 244-247.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.028
Abstract:
ObjectiveTo investigate the predictive value of biomarker combined with conventional echocardiographic parameters of left ventricular diastolic function in preoperative pulmonary systolic pressure(PSP)in patients with severe aortic stenosis(AS). MethodsSixty patients with severe AS(aortic valve area < 1 cm2)were selected.The PSP ≥ 45 mmHg was diagnosed as the pulmonary arterial hypertension(PH), and the patients were divided into the PH group(18 cases)and nonPH group(42 cases).The routine echocardiography, N-terminal Pro B natriuretic peptide(NT-proBNP)and growth differentiation factor-15(GDF-15)were analyzed.The PSP, left ventricular ejection fraction(LVEF), left ventricular diastolic function parameters E/E', mitral valve deceleration time(MVDT)and left atrial volume were evaluated.The correlation between left ventricular diastolic function parameters and biomarker level, and PSP were analyzed. ResultsThe E/E' and left atrial volume in PH group were larger than those in nonPH group(P < 0.05 and P < 0.01), and the MVDT in PH group was less than that in nonPH group(P < 0.05).The levels of NT-proBNP and GDF-15 in AS patient were above the normal upper limit.The levels of NT-proBNP and GDF-15 in PH group were higher than those in nonPH group(P < 0.05).The levels of NT-proBNP and GDF-15 in two groups increased with the increasing of PSP(P < 0.01).The ratio of E/E' >14, MVDT>177.5, left atrial volume >100 mL are the independent predictors of PH occurrence in severe patients, and the levels increasing of NT-proBNP and GDF-15 were the reliable predictors of predictive PH(P < 0.01). ConclusionsThe increasing of the levels of left ventricular diastolic dysfunction and biomarkers can predict the development of pulmonary hypertension in patients with severe AS, and it can provide a basis for early intervention in pulmonary hypertension.
2021, 46(2): 248-251.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.029
Abstract:
ObjectiveTo explore of the clinical value of transthoracic thickness(NT)ultrasound combined with levels of plasma associated protein A(PAPP-A)and disintegrin-metalloproteinase 12(ADAM12)in the prenatal screening of Down's syndrome(DS). MethodsThree hundred and twenty-three women with pregnancy 11 to 14 weeks were examined using B-ultrasound, and the serum levels of PAPP-A and ADAM12 at 15 to 21 weeks of gestation were measured.The results between the single detection of NT, PAPP-A and ADAM12, and combination detection of NT, PAPP-A and ADAM12 in the diagnsois of DS were compared. ResultsFifteen, 19, 20 and 6 high-risk pregnant women were identified using the single detection of NT, PAPP-A and ADAM12, and combination detection of NT, PAPP-A and ADAM12, respectively.Two, 2 and 1 cases were missed diagnosis using the detetcion of NT, PAPP-A and ADAM12, respectively.The sensitivity, accuracy, specificity, negative predictive value and positive predictive value of the combination detection of NT, PAPP-A and ADAM12 were significantly higher than those of single of NT, serum PAPP-A and ADAM12(P < 0.05).The areas under the ROC of the single detection of NT, serum PAPP-A and ADAM12, and combination detection were 0.802, 0.729, 0.762 and 0.905, respectively.The ROC curve area of the combination detection was significantly higher than that of single detetcion of NT, serum PAPP-A and ADAM12(P < 0.05). ConclusionsThe combination detection of NT, serum PAPP-A and ADAM12 can significantly improve the detection rate of DS, and has good clinical value.
2021, 46(2): 251-254.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.030
Abstract:
ObjectiveTo study the effects of different image post-processing techniques on the detection rate of aortic dissection. MethodsOne hundred and six patients with aortic dissection were detected using the multi-slice spiral CT.The maximum intenstity projection(MIP), volume rendering(VR), multiplanar reconstruction(MPR), curved planar reconstruction(CPR)and surface cover imaging(SSD)were used for image post-processing. ResultsThe fracture detection rate of original horizontal axis images was 37.7%, and the detection rates of interlayer fracture of MIP, CPR, MPR, VR and SSD were 0.0%, 46.2%, 69.8%, 65.1% and 39.6%, respectively.The break in 97 cases could be clearly showed, and the detection rate of break was 91.5%.The poor show in 9 patients were identified due to the small diameter of the rupture, artifact of the ascending aortic root or complete thrombosis of pseudolumen.The detection rate of MPR, CPR and VR for fracture were significantly higher than that of SSD and MIP(P < 0.01).According to DeBakey type, 47 cases(44.3%)were type Ⅰ, 17 cases(16.0%)were type Ⅱ and 42 cases(39.6%)were type Ⅲ.The detection accuracy of MPR and VR for type Ⅰ and Ⅱ was better than those of MIP, CPR and SSD(P < 0.01), and the detection accuracy of CPR and MPR for type Ⅲ was better than that of MIP and SSD(P < 0.01). ConclusionsThe CT scanning combined with image post-processing technique has certain advantages in showing the rupture of aortic dissection.Different image post-processing techniques have different advantages and disadvantages, and the MPR is simple to operate, and has strong displaying ability for interlayer fracture and accurate typing, and can be taken as the first choice.
2021, 46(2): 255-258, 262.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.031
Abstract:
ObjectiveTo investigate the current situation of safety culture cognition of nursing students on patients in a third-class A hospital in Shanghai, and analyze the related influencing factors. MethodsA total of 118 nursing students were surveyed using the general information questionnaire and Hospital Survey on Patient Safety Culture by random sampling method. ResultsThe total positive response rate of 118 nursing students was 68.21%.The advantage dimensions included the supervisor/manager expectations and actions promoting safety(90.11%), organizational learning-continuous improvement(87.01%), teamwork across hospital units(86.44%) and management support for patient safety(76.27%).The disadvantage dimension was the nonpunitive response to error(31.07%).The results of single factor analysis showed that the influencing factors of the positive response rate of nursing students were internship duration, nursing errors and patient safety culture training(P < 0.05).The results of binary logistic regression linear analysis showed that the independent influencing factors of the positive response rate of nursing students was the safety culture training of patients(P < 0.05). ConclusionsThe level of patient safety culture of nursing students in practice is at the middle level, and the non-punitive response to errors should be paid more attention.The practice nursing students' cognition of patients' safety literacy level is affected by many reasons.Nursing educators should strengthen the construction of non-punitive nursing safety culture, optimize the curriculum setting of patient safety culture, and strengthen the related training.
2021, 46(2): 259-262.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.032
Abstract:
ObjectiveTo investigate the clinical effect of Pender health promotion model in the treatment of limb fractures. MethodsA total of 112 patients with limb fractures treated with surgery were divided into the control group and observation group according to the random number table(56 cases in each group).The control group was nursed using routine care, and the observation group was nursed using the Pender health promotion model care.The clinical efficacy, healthy behavior before and after intervention, negative emotion and incidence rate of postoperative limb swelling were compared between two groups. ResultsThere was no statistical significance in the total effective rate between two groups(P>0.05).The scores of the mental health, interpersonal relationship, physical activity, health responsibility, stress management, nutrition and healthy behavior in observation group after 1 month of intervention were higher than those in control group(P < 0.01).The scores of SAS and SDS in observation group were higher than those in control group(P < 0.01), the incidence rate of grade Ⅰ swelling in observation group after 7 d of operation were higher than that in control group, and the differences of the incidence rates of grade Ⅱ and Ⅲ swelling between two groups were not statistically significant(P>0.05). ConclusionsPender health promotion model care is effective in the treatment of limb fractures, which can improve the healthy behavior, and reduce the negative emotions and limb swelling.
2021, 46(2): 263-265, 269.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.033
Abstract:
ObjectiveTo explore the status of Hope level and influencing factors of hospitalization patients with primary liver cancer. MethodsThe hope level and general condition of hospitalized patients with primary liver cancer were investigated using the Herth hope index(HHI) and author's self-contained general condition questionnaire. ResultsThe overall hope level score of inpatients with primary liver cancer was (37.99±4.51), and the average score of which was above the upper middle level; the hope level of different age, gender, education level, marital status, working status, monthly income per household, medical payment method and diagnosis informed patients were different(P < 0.05 to P < 0.01).The patients' age, education level, family per capita monthly income were significantly correlated the hope levels(P < 0.05 to P < 0.01). ConclusionsThe hope level of hospitalized patients with primary liver cancer is at a medium-high level.Medical staff should actively take targeted measures to improve the level of hope of patients with primary liver cancer.
2021, 46(2): 266-269.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.034
Abstract:
ObjectiveTo explore the mechanism among fear avoidance belief, psychological flexibility and phobia behavior in patients with chronic low back and leg pain, and improve the intervention effects of medical staff on specific pain psychology. MethodsA total of 250 patients with lumbar disc herniation were surveyed using the General Information Questionnaire, Fear-Avoid Faith Questionnaire, Acceptance and Action Questionnaire and Tampa Score for Dysxia, and the data were statistically analyzed using SPSS24.0 software. ResultsThe total average scores of fear-avoidance belief, psychological flexibility and anxiety disorder Tampa were 48.00(33.75, 59.00), 24.00(18.00, 29.00)and 43.00(37.00, 46.00), respectively.The fear avoidance belief were negative correlation with psychological flexibility(P < 0.01), and positive correlation with fear score(P < 0.01).The psychological flexibility was negative correlation with fear score(P < 0.01).The direct effect of fear avoidance belief on fear behavior was 0.93, the indirect effect of transformational leadership on its relationship was 0.46, and the mediation effect accounted for 33% of the total effect. ConclusionsIn this study, the scores of fear avoidance belief and phobia behavior of patients is just above the medium level, and the psychological flexibility was at the medium level.Encouraging the expression of the own emotions and continuous improving the pain response belief can improve the recovery outcome of patients.
2021, 46(2): 270-272.
doi: 10.13898/j.cnki.issn.1000-2200.2021.02.035
Abstract:
ObjectiveTo explore the effects of anhydrous alcohol by subcutaneous injection on the appearance and morphology of skin, and establish a simple and repeatable animal model of scar. MethodsTwenty-seven New Zealand white rabbits, weighing 1.5 kg, were randomly divided into the A group, B group and C group.The 99.5% alcohol was injected into the dorsal dermis of rabbits in A, B and C groups at the doses of 1, 2 and 3 mL/kg, respectively.The changes of injection sites at 7, 30 and 90 d were observed according to the POSAS scoring standard and microscopic appearance for finding out the best dose. ResultsThe tissue similar to human hypertrophic scar in B group was found at 30 d of injection.The HE staining showed the epidermal layer significantly thickened, and the collagen fiber arrangement disorderedin the dermis.The results of type Ⅰ collagen fiber IHC staining showed that the type Ⅰ collagen was stained for brown, and the brown granules were found in the cytoplasm, and the number of type Ⅰ collagen fibers increased significantly under the microscope. ConclusionsThe hypertrophic scar formed by 2 mL/kg anhydrous alcoholic by subcutaneous injection is similar to the human hypertrophic scar, and can be used as one of the animal models in studying the mechanism of hypertrophic scar and evaluating the treatment.
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