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2006 Vol. 31, No. 6
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2006, 31(6): 567-569.
Abstract:
Objective: To set up a vertical transmission animal model by genital infection with ureaplasma urealyticum(UU) during the course of cyesis.Methods: Kunming mice were infected by serotype 4 UU during the period of pregnancy through vagina,the vertical transmission from mother to filial generation was observed by UU culture and immumohistochemical staining test.Results: UU positive rates from the lung and spleen in the newborn mice by UU infection(3.5×104 CCU/ml,5×105 CCU/ml,and 106 CCU/ml) were 0 and 0,2.7 and 1.4,and 74.4 and 30.3,respectively.Conclusions: The UU vertical transmission animal model during the course of cyesis was constructed successfaly through genital infection with UU in the pregnant mice.
Objective: To set up a vertical transmission animal model by genital infection with ureaplasma urealyticum(UU) during the course of cyesis.Methods: Kunming mice were infected by serotype 4 UU during the period of pregnancy through vagina,the vertical transmission from mother to filial generation was observed by UU culture and immumohistochemical staining test.Results: UU positive rates from the lung and spleen in the newborn mice by UU infection(3.5×104 CCU/ml,5×105 CCU/ml,and 106 CCU/ml) were 0 and 0,2.7 and 1.4,and 74.4 and 30.3,respectively.Conclusions: The UU vertical transmission animal model during the course of cyesis was constructed successfaly through genital infection with UU in the pregnant mice.
2006, 31(6): 569-571.
Abstract:
Objective: To explore the significance of determination of ornithine decarboxylase(ODC) messenger RNA and content of polyamine in human glioma.Methods: RT-PCR was used to examine ODC mRNA expression in human glioma and high performance liquid chromatograph(HPLC) was used to determine the content of polyamine in tumor compared with control group.Results: The expression level of ODC mRNA was increased in gliomas than nomal nervous tissues and the content of spermine and spermidine in tumor tissues was higher than in normal tissues(P<0.01),but there was no difference of the content of putrescine between glioma and normal tissues (P>0.05).Conclusions: It was evidence that the high ODC activation and high content of spermine were closely correlated with the growth of glioma.ODC may represent a tumor marker and may play an important role in diagnosis and prognosis of glioma.It may be a important method for biological immunotherapy.
Objective: To explore the significance of determination of ornithine decarboxylase(ODC) messenger RNA and content of polyamine in human glioma.Methods: RT-PCR was used to examine ODC mRNA expression in human glioma and high performance liquid chromatograph(HPLC) was used to determine the content of polyamine in tumor compared with control group.Results: The expression level of ODC mRNA was increased in gliomas than nomal nervous tissues and the content of spermine and spermidine in tumor tissues was higher than in normal tissues(P<0.01),but there was no difference of the content of putrescine between glioma and normal tissues (P>0.05).Conclusions: It was evidence that the high ODC activation and high content of spermine were closely correlated with the growth of glioma.ODC may represent a tumor marker and may play an important role in diagnosis and prognosis of glioma.It may be a important method for biological immunotherapy.
2006, 31(6): 572-574.
Abstract:
Objective: To investgate the relationship between p53,p16,bcl-2,c-fos gene expression level and cell apoptosis in cerebral glioma with the development and progression.Methods: The expression of p53,p16,bcl-2,c-fos protein was detected in 150 cases of different grade cerebral glioma by immunohistochemistry and cell apoptosis by using in situ end labeling(ISEL) technique.Results: The positive expression rate of p53,p16,bcl-2,c-fos protein in 150 cases of cerebral glioma was 56.67,38.67,61.37, 46.67,respectively;There was significant difference of the expression of p53,p16,bcl-2 protein among Ⅰ-Ⅳgrade glioma (P<0.005),there was no significant difference of the expression of c-fos protein(P>0.05).With the higher of the positive intensity of bcl-2 protein,cell apoptosis was decrease in the tumor,but there was no significant difference of the cell apoptosis (P>0.05).Conclusions: The abnormal expression of p53,p16,bcl-2,c-fos protein played an important role in the development and progression of cerebral glioma.The cooperation of the p53,p16,bcl-2,c-fos protein may cause disorder of cell apoptosis,and unbalance of cell proliferation and apoptosis.Then the detection of p53,p16,bcl-2,c-fos protein may play an important role in prognosis and clinic gene therapy.
Objective: To investgate the relationship between p53,p16,bcl-2,c-fos gene expression level and cell apoptosis in cerebral glioma with the development and progression.Methods: The expression of p53,p16,bcl-2,c-fos protein was detected in 150 cases of different grade cerebral glioma by immunohistochemistry and cell apoptosis by using in situ end labeling(ISEL) technique.Results: The positive expression rate of p53,p16,bcl-2,c-fos protein in 150 cases of cerebral glioma was 56.67,38.67,61.37, 46.67,respectively;There was significant difference of the expression of p53,p16,bcl-2 protein among Ⅰ-Ⅳgrade glioma (P<0.005),there was no significant difference of the expression of c-fos protein(P>0.05).With the higher of the positive intensity of bcl-2 protein,cell apoptosis was decrease in the tumor,but there was no significant difference of the cell apoptosis (P>0.05).Conclusions: The abnormal expression of p53,p16,bcl-2,c-fos protein played an important role in the development and progression of cerebral glioma.The cooperation of the p53,p16,bcl-2,c-fos protein may cause disorder of cell apoptosis,and unbalance of cell proliferation and apoptosis.Then the detection of p53,p16,bcl-2,c-fos protein may play an important role in prognosis and clinic gene therapy.
2006, 31(6): 575-578.
Abstract:
Objective: To investigate the effect of limited resuscitation in a model of uncontrolled hemorrhagic shock.Methods: Uncontrolled hemorrhagic shock model was established in 40 rabbits.When mean arterial pressure(MAP) was lowered to 40 mmHg and maintained 30 minutes,resuscitation was begun.Ringer's solution in fusion was continued as needed to maintain the following desired requirements:Group N4 without resuscitation,Group N3 with the most fluid,Group N2 with more fluid,Group N1 with little fluid after shock.Besides,GroupN5 without shock.MAP,the death rate,the blood loss,superoxide dismutase(SOD),the hematocrit(Hct) of all animals were observed for 210 minutes or until death.Results: MAP,death rate,blood loss,SOD,Hct of Group N5 were better than Group N1,N2,N3(P<0.01).MAP,death rate,blood loss and Hct of Group N4 is worse than Group N1,N2,N3(P<0.01).The death rate of Group N4 was the first in all groups.With the increase of fluid in resuscitation,death rate became higher at last and the blood loss became high in resuscitation(P<0.01).Hct and MAP in Group N1 were significantly higher than in Group N2,N3,N4 in the end(P<0.01).SOD of Group N1 was the highest in all groups except Group N5(P<0.01).Conclusions: Attempts to achieve normal MAP during uncontrolled bleeding will result in more hemorrhage volume and markedly higher mortality.Limited resuscitation before hemostat could significantly reduce death rate and blood loss for the following treatment.
Objective: To investigate the effect of limited resuscitation in a model of uncontrolled hemorrhagic shock.Methods: Uncontrolled hemorrhagic shock model was established in 40 rabbits.When mean arterial pressure(MAP) was lowered to 40 mmHg and maintained 30 minutes,resuscitation was begun.Ringer's solution in fusion was continued as needed to maintain the following desired requirements:Group N4 without resuscitation,Group N3 with the most fluid,Group N2 with more fluid,Group N1 with little fluid after shock.Besides,GroupN5 without shock.MAP,the death rate,the blood loss,superoxide dismutase(SOD),the hematocrit(Hct) of all animals were observed for 210 minutes or until death.Results: MAP,death rate,blood loss,SOD,Hct of Group N5 were better than Group N1,N2,N3(P<0.01).MAP,death rate,blood loss and Hct of Group N4 is worse than Group N1,N2,N3(P<0.01).The death rate of Group N4 was the first in all groups.With the increase of fluid in resuscitation,death rate became higher at last and the blood loss became high in resuscitation(P<0.01).Hct and MAP in Group N1 were significantly higher than in Group N2,N3,N4 in the end(P<0.01).SOD of Group N1 was the highest in all groups except Group N5(P<0.01).Conclusions: Attempts to achieve normal MAP during uncontrolled bleeding will result in more hemorrhage volume and markedly higher mortality.Limited resuscitation before hemostat could significantly reduce death rate and blood loss for the following treatment.
2006, 31(6): 579-581.
Abstract:
Objective: To investigate the expression of fragile histidine triad(FHIT) gene in gallbladder carcinoma and to explore its possible relationship with clinicopathological parameters and prognosis of gallbladder carcinoma.Methods: The expression of FHIT in 51 cases of primary gallbladder carcinoma,15 cases of gallbladder adenoma and 12 cases of chronic cholecystitis was determined by streptavidin-peroxidase immunohistochemical method.Results: The positive expression rates of FHIT in gallbladder carcinoma,gallbladder adenoma and chronic cholecystitis were 47.1,66.7 and 91.7,respectively,and their difference had statistical significance(P<0.005).In gallbladder carcinoma,the expression of FHIT had no correlation with the age,gender,histologic type,Nevin staging and gallbladder stone(P>0.05),but loss of FHIT expression correlated significantly with higher histological grading and lymph node or distant metastasis as well as lesser survival time after operation(P<0.05).Conclusions: FHIT gene may be a candidate tumor suppressor gene of gallbladder carcinoma.Loss of FHIT expression plays an important role in the pathogenesis and evolution of gallbladder carcinoma and may be used as a new indicator for clinical assessment of tumor biological behavior and prognosis in patients with gallbladder carcinoma.
Objective: To investigate the expression of fragile histidine triad(FHIT) gene in gallbladder carcinoma and to explore its possible relationship with clinicopathological parameters and prognosis of gallbladder carcinoma.Methods: The expression of FHIT in 51 cases of primary gallbladder carcinoma,15 cases of gallbladder adenoma and 12 cases of chronic cholecystitis was determined by streptavidin-peroxidase immunohistochemical method.Results: The positive expression rates of FHIT in gallbladder carcinoma,gallbladder adenoma and chronic cholecystitis were 47.1,66.7 and 91.7,respectively,and their difference had statistical significance(P<0.005).In gallbladder carcinoma,the expression of FHIT had no correlation with the age,gender,histologic type,Nevin staging and gallbladder stone(P>0.05),but loss of FHIT expression correlated significantly with higher histological grading and lymph node or distant metastasis as well as lesser survival time after operation(P<0.05).Conclusions: FHIT gene may be a candidate tumor suppressor gene of gallbladder carcinoma.Loss of FHIT expression plays an important role in the pathogenesis and evolution of gallbladder carcinoma and may be used as a new indicator for clinical assessment of tumor biological behavior and prognosis in patients with gallbladder carcinoma.
2006, 31(6): 582-583.
Abstract:
Objective: To observe protective effect of buflomdil hydrochloride on the neuron of damaged sciatic nerve in rats.Methods: Sciatic nerve lesion model was established in rats,and the morphological changes of neuron cells of DRG treated with buflomedil hydrochloride were observed by light and electron microscope.Results: At the end of 4 weeks,buflomedil hydrochloride significantly decreased the damage of neuron of DRG.Conclusions: Buflomedic hydrochloride shows protective effect on neuron damaged sciatic nerve.
Objective: To observe protective effect of buflomdil hydrochloride on the neuron of damaged sciatic nerve in rats.Methods: Sciatic nerve lesion model was established in rats,and the morphological changes of neuron cells of DRG treated with buflomedil hydrochloride were observed by light and electron microscope.Results: At the end of 4 weeks,buflomedil hydrochloride significantly decreased the damage of neuron of DRG.Conclusions: Buflomedic hydrochloride shows protective effect on neuron damaged sciatic nerve.
2006, 31(6): 584-586.
Abstract:
Objective: To summarize the experience of intervention and thrombectomy for the left iliac vein compression syndromw with low limb deep venous thrombosis(DVT).Methods: The placement of DVT filter and obliterans from femoral vein was performed,and the balloon was also performed.The dilatation and endovascular stent of iliac vein was performed.Results: Stricture and obstruction were found in left iliac vein in different extents.Following up in these patients ranged from 1 month to 36 months.The limb swelling was alleviated completely in 37 patients.More than 2/3 of swelling was alleviated in 5 patients (10.87).More than 1/3 of swelling was alleviated in 3 patients (6.52).The lim swelling was alleviated slightly in one patient (2.17).No perioperative death occurred.Conclusions: The placement of IVC filter and obliterans from femoral vein and balloon dilatation and endovascular stent of iliac vein for treatment of Cockett syndrome are minimally invasive,safe and effective with low reccurence rate.
Objective: To summarize the experience of intervention and thrombectomy for the left iliac vein compression syndromw with low limb deep venous thrombosis(DVT).Methods: The placement of DVT filter and obliterans from femoral vein was performed,and the balloon was also performed.The dilatation and endovascular stent of iliac vein was performed.Results: Stricture and obstruction were found in left iliac vein in different extents.Following up in these patients ranged from 1 month to 36 months.The limb swelling was alleviated completely in 37 patients.More than 2/3 of swelling was alleviated in 5 patients (10.87).More than 1/3 of swelling was alleviated in 3 patients (6.52).The lim swelling was alleviated slightly in one patient (2.17).No perioperative death occurred.Conclusions: The placement of IVC filter and obliterans from femoral vein and balloon dilatation and endovascular stent of iliac vein for treatment of Cockett syndrome are minimally invasive,safe and effective with low reccurence rate.
2006, 31(6): 587-589.
Abstract:
Objective: To evaluate the effect of endovascular treatment of the left iliac vein compression syndrome(Cockett syndrome).Methods: Ninety-three patients with Cockett syndrome were treated with endovascular treatment.The seldinger technic was used for puncture of the left femoral veins.The catheter and balloon were employed to dilate the left iliac veins,and then the self-expension "Z" stent or wallstnet was placed.The secondary operation was performed for treatment of the severe reflux of the femoral veins.Results: Ninety of 93 patients were cured and 73 stents were placed.Three left iliac veins were ruptured and the local haematoma were formed.No further damage occurred.The iliac veins were patent after the placement of the stent and no stent migration that would affect the blood stream of the right iliac vein and inferior cana veca occurred.The limb swelling was obviously alleviated.Conclusions: The endovascular management combined with the femoral vein constriction to treat with Cockett syndrome have good near future effect.The procedure is minimally invasive,simple,safe and effective.
Objective: To evaluate the effect of endovascular treatment of the left iliac vein compression syndrome(Cockett syndrome).Methods: Ninety-three patients with Cockett syndrome were treated with endovascular treatment.The seldinger technic was used for puncture of the left femoral veins.The catheter and balloon were employed to dilate the left iliac veins,and then the self-expension "Z" stent or wallstnet was placed.The secondary operation was performed for treatment of the severe reflux of the femoral veins.Results: Ninety of 93 patients were cured and 73 stents were placed.Three left iliac veins were ruptured and the local haematoma were formed.No further damage occurred.The iliac veins were patent after the placement of the stent and no stent migration that would affect the blood stream of the right iliac vein and inferior cana veca occurred.The limb swelling was obviously alleviated.Conclusions: The endovascular management combined with the femoral vein constriction to treat with Cockett syndrome have good near future effect.The procedure is minimally invasive,simple,safe and effective.
2006, 31(6): 589-591.
Abstract:
Objective: To summarize the experience of interventional therapy for Budd-Chiari syndrome(BCS).Methods: Inferior vera cava(IVC) and hepatic vein venography were first carried out,the obliteration or stenosis in the IVC was opened or dilated with the hard tip of guide wire or puncture needle and balloon,then a stent was implanted.Results: The procedure was successful in 318 out of 359 patients including IVC intervention in 306 patients,and hepatic vein intervention in 12 patients.IVC stent was used in 232 patients and hepatic vein stent in 2 patients.There was no pulmonary embolism happened.There were liver coma in 1 patient and acute heart dysfunction in 21 patients.Two patients were combined with acute IVC thrombosis.Follow up in 248 cases ranged from 6 to 126 months.The recurrence was found in 21 patients.Conclusions: Interventional therapy for Budd-Chiari syndrome is less invasive,safe,effective,with less complications and fast recovery and it is the first choice for BCS.
Objective: To summarize the experience of interventional therapy for Budd-Chiari syndrome(BCS).Methods: Inferior vera cava(IVC) and hepatic vein venography were first carried out,the obliteration or stenosis in the IVC was opened or dilated with the hard tip of guide wire or puncture needle and balloon,then a stent was implanted.Results: The procedure was successful in 318 out of 359 patients including IVC intervention in 306 patients,and hepatic vein intervention in 12 patients.IVC stent was used in 232 patients and hepatic vein stent in 2 patients.There was no pulmonary embolism happened.There were liver coma in 1 patient and acute heart dysfunction in 21 patients.Two patients were combined with acute IVC thrombosis.Follow up in 248 cases ranged from 6 to 126 months.The recurrence was found in 21 patients.Conclusions: Interventional therapy for Budd-Chiari syndrome is less invasive,safe,effective,with less complications and fast recovery and it is the first choice for BCS.
2006, 31(6): 592-594.
Abstract:
Objective: To summarize the experience of endovascular exclusion on aortic diseases,and investigate the intervention therapeutic indications and operational essentials about aortic diseases.Methods: Tracheal intubation anesthesia was employed in all 15 patients.The endovascular polyester-covered stent graft exclusion was used to obturate the tear entry on the proximal end of descending aorta in 8 patients with dissecting aneurysm of aorta and the left subclavian artery was obturated in 1 patient.One in 6 abdominal aneuryoms was placed with the straight endovascular polyester-covered stent graft exclusion while other patients were placed with crotched stent graft through double femoral artery.The percutaneous transluminal balloon dilatation of crotched stent graft placement was performed in 1 patient with the early aortoilion arterial occlusive disease.Results: There were no death in all treated patients,and pseudocele and cavity of aorta were not found by phlebography after endovascular exclusion.Type I internal hemorrhage was detected in 2 ptients who were followed up 6 months,and the pseudocele of aorta thrombosis was found partly.One patient died abruptly 1 year later after operation.Conclusions: It is safe,feasible,effective in endovascular exclusion on aortic diseases,and it could replace traditional operation gradually.Its therapeutic indications could be increased continuously.
Objective: To summarize the experience of endovascular exclusion on aortic diseases,and investigate the intervention therapeutic indications and operational essentials about aortic diseases.Methods: Tracheal intubation anesthesia was employed in all 15 patients.The endovascular polyester-covered stent graft exclusion was used to obturate the tear entry on the proximal end of descending aorta in 8 patients with dissecting aneurysm of aorta and the left subclavian artery was obturated in 1 patient.One in 6 abdominal aneuryoms was placed with the straight endovascular polyester-covered stent graft exclusion while other patients were placed with crotched stent graft through double femoral artery.The percutaneous transluminal balloon dilatation of crotched stent graft placement was performed in 1 patient with the early aortoilion arterial occlusive disease.Results: There were no death in all treated patients,and pseudocele and cavity of aorta were not found by phlebography after endovascular exclusion.Type I internal hemorrhage was detected in 2 ptients who were followed up 6 months,and the pseudocele of aorta thrombosis was found partly.One patient died abruptly 1 year later after operation.Conclusions: It is safe,feasible,effective in endovascular exclusion on aortic diseases,and it could replace traditional operation gradually.Its therapeutic indications could be increased continuously.
2006, 31(6): 594-596.
Abstract:
Objective: To summarize the experience of surgical therapy on Takayasu arteritis(TA),and investigate the timing of the surgical therapy and effective therapy methods on this disease.Methods: Eleven patients underwent surgical therapy,and 8 artery bypass operation,and 3 cases intervention therapy.The aim of therapy was to alleviate the severe symptoms of brain ischemia and refractory hypertension.The time of operation was appropriate.Results: Two patients died of brain oedema.The good curative effect was achieved in other patients.Follow-up in all the patients ranged from 6 months to 3 years.The symptoms were alleviated in all patients,and no recrudescence were found.The efficience was 63.6.Conclusions: On the condition that tackling operational time and adopting effective countermeasure,the good curative effect could be achieved in TA patients by surgical therapy.And safeguard of brain must be recognised in TA of Shimizi-sano.Intervention therapy still need incessant exploration and enhancement.
Objective: To summarize the experience of surgical therapy on Takayasu arteritis(TA),and investigate the timing of the surgical therapy and effective therapy methods on this disease.Methods: Eleven patients underwent surgical therapy,and 8 artery bypass operation,and 3 cases intervention therapy.The aim of therapy was to alleviate the severe symptoms of brain ischemia and refractory hypertension.The time of operation was appropriate.Results: Two patients died of brain oedema.The good curative effect was achieved in other patients.Follow-up in all the patients ranged from 6 months to 3 years.The symptoms were alleviated in all patients,and no recrudescence were found.The efficience was 63.6.Conclusions: On the condition that tackling operational time and adopting effective countermeasure,the good curative effect could be achieved in TA patients by surgical therapy.And safeguard of brain must be recognised in TA of Shimizi-sano.Intervention therapy still need incessant exploration and enhancement.
2006, 31(6): 596-597.
Abstract:
Objective: To investigate effective surgical therapy and essentials on Budd-Chiari syndrome.Methods: The IVC venography was used to investigate the diseased segment,and the open surgical resection of abnormal segment in IVC was performed in 3 patients through an inverse Y incision on abdomen.The double membrane was found in one patient and the surgical resection and obliterans from IVC were performed,and the balloon dilatation and angioplasty with e-PTFE vascular graft were also performed.Results: All the operations were successful.There were no death and pulmonary embolus.The syndromes of IVC hypertension was alleviated completely.The following up ranged from 6 months to 14 months.The stritcture was found after 6 months in one patient,and the syndromes disapeared after the percutaneous transluminal angioplasty and endovascula stent was performed.Conclusions: Radical surgery on Budd-Chiari syndrome through abdomen approach was less invasive,safty with less complications.
Objective: To investigate effective surgical therapy and essentials on Budd-Chiari syndrome.Methods: The IVC venography was used to investigate the diseased segment,and the open surgical resection of abnormal segment in IVC was performed in 3 patients through an inverse Y incision on abdomen.The double membrane was found in one patient and the surgical resection and obliterans from IVC were performed,and the balloon dilatation and angioplasty with e-PTFE vascular graft were also performed.Results: All the operations were successful.There were no death and pulmonary embolus.The syndromes of IVC hypertension was alleviated completely.The following up ranged from 6 months to 14 months.The stritcture was found after 6 months in one patient,and the syndromes disapeared after the percutaneous transluminal angioplasty and endovascula stent was performed.Conclusions: Radical surgery on Budd-Chiari syndrome through abdomen approach was less invasive,safty with less complications.
2006, 31(6): 598-600.
Abstract:
Objective: To summarize surgical experience on undergoing open repair or endovascular treatment of infrarenal abdominal aortic aneurysm(AAA).Methods: Consecutive 25 patients with infrarenal AAA who were treated by traditional open operation(19 cases),endovascular treatment(4 cases) and non-surgical treatment(2 cases) were retrospectively reviewed.Results: Twenty-three patients were performed by operation,but 2 cases which were rupture AAA were died perioperatively due to multiple organ dysfunction syndrome(MODS),pulmonary infection and acute respiratory distress syndrome(ARDS),respectively.The other 2 rupture AAA cases whose situations were serious were died without further treatment.The perioperatively mortality was 8.7.Eighteen cases were followed-up from 3 months to 6 years,the mean duration was 3.6 years.No aneurysm recurred,no pseudo-aneurysm and no rupture bleed.The grafts were patent.Cases which underwent endovascular treatment were no stent migration,no intestine ischemic,no endoleak and the stentgrafts were patent.Conclusions: The efficacy of open operation of AAA is satisfactory and safe.Endovascular treatment is specially suit for high severe AAA patients.
Objective: To summarize surgical experience on undergoing open repair or endovascular treatment of infrarenal abdominal aortic aneurysm(AAA).Methods: Consecutive 25 patients with infrarenal AAA who were treated by traditional open operation(19 cases),endovascular treatment(4 cases) and non-surgical treatment(2 cases) were retrospectively reviewed.Results: Twenty-three patients were performed by operation,but 2 cases which were rupture AAA were died perioperatively due to multiple organ dysfunction syndrome(MODS),pulmonary infection and acute respiratory distress syndrome(ARDS),respectively.The other 2 rupture AAA cases whose situations were serious were died without further treatment.The perioperatively mortality was 8.7.Eighteen cases were followed-up from 3 months to 6 years,the mean duration was 3.6 years.No aneurysm recurred,no pseudo-aneurysm and no rupture bleed.The grafts were patent.Cases which underwent endovascular treatment were no stent migration,no intestine ischemic,no endoleak and the stentgrafts were patent.Conclusions: The efficacy of open operation of AAA is satisfactory and safe.Endovascular treatment is specially suit for high severe AAA patients.
2006, 31(6): 601-603.
Abstract:
Objective: To observe the anti-inflammatory and analgesic activities of 2-(E)-(un)substituted benzylidene-5-dimethylamido-cyclopentanone(MB4) and its irritating effect on gastrointestinal tract.Methods: Local besmear with xylene induced swelling of mice ear and the mice writhing caused by intraperitoneal injection acetic acid,the irritability of gastric mucous membrane by using intragastric administration.Results: MB4(20mg/kg,40mg/kg) may inhibit the swelling of mice ear induced by xylene(P<0.05 and P<0.01),reduce writhing amount(P<0.01),but its irritating effect on gastrointestinal tract was slighter than that of indomethacin.Conclusions: MB4 possess anti-inflammation and analgesic actions,but its irritative effects of gastric mucous membrane are small.
Objective: To observe the anti-inflammatory and analgesic activities of 2-(E)-(un)substituted benzylidene-5-dimethylamido-cyclopentanone(MB4) and its irritating effect on gastrointestinal tract.Methods: Local besmear with xylene induced swelling of mice ear and the mice writhing caused by intraperitoneal injection acetic acid,the irritability of gastric mucous membrane by using intragastric administration.Results: MB4(20mg/kg,40mg/kg) may inhibit the swelling of mice ear induced by xylene(P<0.05 and P<0.01),reduce writhing amount(P<0.01),but its irritating effect on gastrointestinal tract was slighter than that of indomethacin.Conclusions: MB4 possess anti-inflammation and analgesic actions,but its irritative effects of gastric mucous membrane are small.
2006, 31(6): 603-604.
Abstract:
Objective: To observe the effect of ischemia-reperfusion on the electrophyiology of diaphragm atic muscle in rabbits.Methods: Twelve healthy adult rabbits were randomly divided into experimental and control groups(each of six rabbits).The ischemia-reperfusion injury animal model was produced in rabbits.The diaphragmatic electromyogram(EMGdi) was recorded by computer.The contents of the high/low(H/L) frequency ratio and central frequency(Fc) were detected by Fast Fourier Transform(FFT) at the times of preischemia,post-ischemia and post-reperfusion.Data were analysed by variance analysis and q test.Results: The Fc in experimental group were significantly lower than that of control group(P<0.01) at one hour and two hours after ischemia-reperfusion injury.Conclusions: The electro-activity of diaphragm has been injuried by ischemia-reperfusion.
Objective: To observe the effect of ischemia-reperfusion on the electrophyiology of diaphragm atic muscle in rabbits.Methods: Twelve healthy adult rabbits were randomly divided into experimental and control groups(each of six rabbits).The ischemia-reperfusion injury animal model was produced in rabbits.The diaphragmatic electromyogram(EMGdi) was recorded by computer.The contents of the high/low(H/L) frequency ratio and central frequency(Fc) were detected by Fast Fourier Transform(FFT) at the times of preischemia,post-ischemia and post-reperfusion.Data were analysed by variance analysis and q test.Results: The Fc in experimental group were significantly lower than that of control group(P<0.01) at one hour and two hours after ischemia-reperfusion injury.Conclusions: The electro-activity of diaphragm has been injuried by ischemia-reperfusion.
2006, 31(6): 605-607.
Abstract:
Objective: To evaluate the relationship between systolic blood pressure(SBP) or diastolic blood pressure(DBP) on admission and early mortality in patients with acute stroke.Methods: A total of 461 patients admitted within 24 h from stroke onset and followed up for 1 month.Mortality at 1 month after stroke in relation to admission SBP and DBP.Results: Early mortality in patients with acute ischaemic or haemorrhagic stroke in relation to admission SBP and DBP followed a U-curve pattern.The nadir or U-point of the curve occurred in the range of 121-140/81-90 mmHg and 141-160/91-100 mmHg for ischaemic or haemorrhagic stroke patients.The patients with high and low admission BP-values have a higher early mortality(P<0.05~P<0.01).Death due to cerebral oedema was significantly more frequent in patients with high admission SBP-values,whereas death due to cardiovascular disease was more frequent in patients with low admission SBP-values.Conclusions: Acute ischaemic or haemorrhagic stroke patients with high and low admission BP-values have a higher early mortality.Coincidence of heart disease is associated with low initial BP-values.Death due to neurological damage from brain oedema is associated with high initial BP-values.
Objective: To evaluate the relationship between systolic blood pressure(SBP) or diastolic blood pressure(DBP) on admission and early mortality in patients with acute stroke.Methods: A total of 461 patients admitted within 24 h from stroke onset and followed up for 1 month.Mortality at 1 month after stroke in relation to admission SBP and DBP.Results: Early mortality in patients with acute ischaemic or haemorrhagic stroke in relation to admission SBP and DBP followed a U-curve pattern.The nadir or U-point of the curve occurred in the range of 121-140/81-90 mmHg and 141-160/91-100 mmHg for ischaemic or haemorrhagic stroke patients.The patients with high and low admission BP-values have a higher early mortality(P<0.05~P<0.01).Death due to cerebral oedema was significantly more frequent in patients with high admission SBP-values,whereas death due to cardiovascular disease was more frequent in patients with low admission SBP-values.Conclusions: Acute ischaemic or haemorrhagic stroke patients with high and low admission BP-values have a higher early mortality.Coincidence of heart disease is associated with low initial BP-values.Death due to neurological damage from brain oedema is associated with high initial BP-values.
2006, 31(6): 607-608.
Abstract:
Objective: To summarize the experience of application of exraperitoneal colostomy for low rectal carcinomas.Methods: The data of 42 patients with low rectal carcinoma treated by extraperitoneal colostomy were analyzed retrospectively.Results: The operation for all patients were successful.Forty patients undergoing extraperitoneal colostomy were followed up from 6 to 42 months.Only one of them suffered from colostomy stenosis.The morbidity of complications caused by colostomy was 2.5 and 35 patients(87.5) got continence colostomies.The complications of the traditional Mile's operation were 20.6(21 patients),and 28 patients(27.5) got continence colostomies.There was significant difference in the continence and the occurrence of the complications between the two groups(P<0.01).Conclusions: This operation has the advantages of simple manipulation,less complications,better defecation function and easy nursing.It is a safe and effective for treatment of low carcinoma of rectum.
Objective: To summarize the experience of application of exraperitoneal colostomy for low rectal carcinomas.Methods: The data of 42 patients with low rectal carcinoma treated by extraperitoneal colostomy were analyzed retrospectively.Results: The operation for all patients were successful.Forty patients undergoing extraperitoneal colostomy were followed up from 6 to 42 months.Only one of them suffered from colostomy stenosis.The morbidity of complications caused by colostomy was 2.5 and 35 patients(87.5) got continence colostomies.The complications of the traditional Mile's operation were 20.6(21 patients),and 28 patients(27.5) got continence colostomies.There was significant difference in the continence and the occurrence of the complications between the two groups(P<0.01).Conclusions: This operation has the advantages of simple manipulation,less complications,better defecation function and easy nursing.It is a safe and effective for treatment of low carcinoma of rectum.
2006, 31(6): 609-611.
Abstract:
Objective: To investigate the clinical application of postoperative tracheal intubations in patients with obstructive sleep apnea and hyponoea syndrome(OSAHS).Methods: All 26 patients with severe OSAHS underwent uvulopalatopharyngoplasty(UPPP).Nasotracheal intubation was performed and patients received clinical treatment postoperatively such as sedation,analgesia,respiratory care and psychological education.The heart rate,respiratory rate,blood pressure and sarteria oxygen saturation(SAO2) were monitored before,during the treatment and after tracheal exubation.Results: Between 1 hour after intubations and tracheal extubation,the heart rate,respiratory rate and blood pressure were decreased significantly(P<0.05 to P<0.01).SAO2 was increased greatly at 6 hours after treatment(P<0.01).The tolerance of tracheal intubated patients was increased.No severe postoperative complications happened.Conclusions: With active clinical treatments,postoperative tracheal intubations are safe and effective in patients with OSAHS,which can avoid severe postoperative complications after UPPP.
Objective: To investigate the clinical application of postoperative tracheal intubations in patients with obstructive sleep apnea and hyponoea syndrome(OSAHS).Methods: All 26 patients with severe OSAHS underwent uvulopalatopharyngoplasty(UPPP).Nasotracheal intubation was performed and patients received clinical treatment postoperatively such as sedation,analgesia,respiratory care and psychological education.The heart rate,respiratory rate,blood pressure and sarteria oxygen saturation(SAO2) were monitored before,during the treatment and after tracheal exubation.Results: Between 1 hour after intubations and tracheal extubation,the heart rate,respiratory rate and blood pressure were decreased significantly(P<0.05 to P<0.01).SAO2 was increased greatly at 6 hours after treatment(P<0.01).The tolerance of tracheal intubated patients was increased.No severe postoperative complications happened.Conclusions: With active clinical treatments,postoperative tracheal intubations are safe and effective in patients with OSAHS,which can avoid severe postoperative complications after UPPP.
2006, 31(6): 612-613.
Abstract:
Objective: To investigate the changes of endothelin-1 receptor(ETa-R) expression in human myometrium as well as fetal membranes during the course of labor and its relationship to the labor onset.Methods: Immunohistochemcal SABC method and computer quantitative image analysis were employed to determine the levels of ETa-R in human myometrium and fetal membrane before and during the labor.Results: Although the ETa-R was expressed in human myometrium either before or during the parturition,the positive rate and level of ETa-R were significantly higher after the onset of labor(P<0.01).In fetal membranes,the ETa-R was mainly distributed in syncytial trophoblasts and intermediate trophoblasts.The positive rate of ETa-R was increased significantly after the onset of labor(P<0.01),whereas there was no significant difference in the level of ETa-R(P>0.05).Conclusions: The Up-regulation of ETa-R expression in myometrium and fetal membrane during the course of labor suggests that ET-1 may be important in the initiation of human parturition.
Objective: To investigate the changes of endothelin-1 receptor(ETa-R) expression in human myometrium as well as fetal membranes during the course of labor and its relationship to the labor onset.Methods: Immunohistochemcal SABC method and computer quantitative image analysis were employed to determine the levels of ETa-R in human myometrium and fetal membrane before and during the labor.Results: Although the ETa-R was expressed in human myometrium either before or during the parturition,the positive rate and level of ETa-R were significantly higher after the onset of labor(P<0.01).In fetal membranes,the ETa-R was mainly distributed in syncytial trophoblasts and intermediate trophoblasts.The positive rate of ETa-R was increased significantly after the onset of labor(P<0.01),whereas there was no significant difference in the level of ETa-R(P>0.05).Conclusions: The Up-regulation of ETa-R expression in myometrium and fetal membrane during the course of labor suggests that ET-1 may be important in the initiation of human parturition.
2006, 31(6): 614-616.
Abstract:
Objective: To analyze the clinical features and drug sensitivity of paratyphoid A.Methods: Twenty-one cases of paratyphoid A were analyzed retrospectively.The clinical features and drug sensitivity were compared with the cases selected randomly in Chinese Academic Journal(CD) from 1994-1996.Results: The presentation of typical characteristics of typhoid and paratyphoid was 86.1 and 4.8 in the typhoid group and paratyphoid A group respectively;obvious toxic symptoms were observed in 62.5 of the patients in the typhoid group and 38.1 in the paratyphoid A group;The incidence of relative infrequent pulse was 36.4 and 9.5 in the typhoid group and paratyphoid A group respectively;The apathia rate was 51 in the typhoid group and 9.5 in the paratyphoid A group;The incidence rate of enlarged spleen was 12.6 and 52.9 in the typhoid group and paratyphoid A group respectively(P<0.05~P<0.01).The difference was significant.The incidence of fever,rose rash and hepatauxe was 99.1, 14.1 and 19.1 in the typhoid group and 100,9.5 and 29.4 in the paratyphoid A group,respectively;the difference was not significant (P>0.05).The sensitiveness rate of quinolones was 100 and the sensitiveness rate of the third generation ephamycins was above 90.Conclusions: Clinical symptoms of paratyphoid A are not typical.Quinolones is the first medicine for treatment of paratyphoid A,and the third generation ephamycins and chlormycetin are the second choice.
Objective: To analyze the clinical features and drug sensitivity of paratyphoid A.Methods: Twenty-one cases of paratyphoid A were analyzed retrospectively.The clinical features and drug sensitivity were compared with the cases selected randomly in Chinese Academic Journal(CD) from 1994-1996.Results: The presentation of typical characteristics of typhoid and paratyphoid was 86.1 and 4.8 in the typhoid group and paratyphoid A group respectively;obvious toxic symptoms were observed in 62.5 of the patients in the typhoid group and 38.1 in the paratyphoid A group;The incidence of relative infrequent pulse was 36.4 and 9.5 in the typhoid group and paratyphoid A group respectively;The apathia rate was 51 in the typhoid group and 9.5 in the paratyphoid A group;The incidence rate of enlarged spleen was 12.6 and 52.9 in the typhoid group and paratyphoid A group respectively(P<0.05~P<0.01).The difference was significant.The incidence of fever,rose rash and hepatauxe was 99.1, 14.1 and 19.1 in the typhoid group and 100,9.5 and 29.4 in the paratyphoid A group,respectively;the difference was not significant (P>0.05).The sensitiveness rate of quinolones was 100 and the sensitiveness rate of the third generation ephamycins was above 90.Conclusions: Clinical symptoms of paratyphoid A are not typical.Quinolones is the first medicine for treatment of paratyphoid A,and the third generation ephamycins and chlormycetin are the second choice.
2006, 31(6): 616-617.
Abstract:
Objective: To explore the value of serum bilirubin level in diagnosis of coronary heart disease(CHD).Methods: Fifty-two patients with CHD and thirty-six normal controls were divided into two groups.Total bilirubin(TBIL) in serum,total cholesterol(CHO),triglyceride(TG) and high-density lipoproteins (HDL) were measured.Results: The TBIL in serum in patients with CHD was lower than that in normal controls(P<0.01).The TBTL in CHD group showed negative correlativity with CHO and TG(P<0.01).The TBTL in CHD group showed positive correlativity with HDL(P<0.01).Conclusions: TBIL in serum could prevent lipid from oxidation and reduce the occurrence of CHD.
Objective: To explore the value of serum bilirubin level in diagnosis of coronary heart disease(CHD).Methods: Fifty-two patients with CHD and thirty-six normal controls were divided into two groups.Total bilirubin(TBIL) in serum,total cholesterol(CHO),triglyceride(TG) and high-density lipoproteins (HDL) were measured.Results: The TBIL in serum in patients with CHD was lower than that in normal controls(P<0.01).The TBTL in CHD group showed negative correlativity with CHO and TG(P<0.01).The TBTL in CHD group showed positive correlativity with HDL(P<0.01).Conclusions: TBIL in serum could prevent lipid from oxidation and reduce the occurrence of CHD.
2006, 31(6): 618-620.
Abstract:
Objective: To investigated the relationship between serum C-reactive protein (CRP)and macroangiopathy of type 2 diabetes millitus,and the mechanism of Simvastatin in protection of blood vessels.Methods: Sixty-nine cases of type 2 diabetes mellitus were selected,34 of whom had only type 2 diabetes with no complications(group A) and 35 of whom were accompanied by macroangiopathy(group B),and 20 healthy subjects acted as controls(group C).The serum CRP was determined by immuno-turbidimetric.The changes were observed before and after simvastatin treatment.Results: The serum CRP in group A and B were higher than that in group C(P<0.05 and P<0.01),while group B had higher serum CRP levels than group A(P<0.01).Serum CRP had a positive correlation with TC,C-LDL,ox-LDL,SBP,BMI(P<0.05 to P<0.01),and had a negative correlation with C-HDL(P<0.01).After simvastatin treatment,the levels of serum CRP,TC,C-LDL,ox-LDL reduced remarkably(P<0.01).Conclusions: Serum CRP may play an important role in the development and progression of type 2 diabetic macroangiopathy.Simvastation protects the blood vessel by its mechanism of anti-inflammation,anti-oxidation and moderating lipid.
Objective: To investigated the relationship between serum C-reactive protein (CRP)and macroangiopathy of type 2 diabetes millitus,and the mechanism of Simvastatin in protection of blood vessels.Methods: Sixty-nine cases of type 2 diabetes mellitus were selected,34 of whom had only type 2 diabetes with no complications(group A) and 35 of whom were accompanied by macroangiopathy(group B),and 20 healthy subjects acted as controls(group C).The serum CRP was determined by immuno-turbidimetric.The changes were observed before and after simvastatin treatment.Results: The serum CRP in group A and B were higher than that in group C(P<0.05 and P<0.01),while group B had higher serum CRP levels than group A(P<0.01).Serum CRP had a positive correlation with TC,C-LDL,ox-LDL,SBP,BMI(P<0.05 to P<0.01),and had a negative correlation with C-HDL(P<0.01).After simvastatin treatment,the levels of serum CRP,TC,C-LDL,ox-LDL reduced remarkably(P<0.01).Conclusions: Serum CRP may play an important role in the development and progression of type 2 diabetic macroangiopathy.Simvastation protects the blood vessel by its mechanism of anti-inflammation,anti-oxidation and moderating lipid.
2006, 31(6): 620-621.
Abstract:
Objective: To compare the effects and side effects of ropivacaine and racemic bupiacaine in epidural analgesia after cesarean section.Methods: Fifty full-terms,nulliparous women undergoing cesarean section under eqidural anesthesia ware enrolled in this randomized double-blind study and were divided into ropivacaine group and racemic bupiacaine group.After operation,the patients were randomized to receive 1.5 ropivacaine(group R,n=25)or 0.125 bupivacaine(group B,n=25)for patient-controlled epidural analgesia(PCEA).The PCEA solution for the 2 groups contained fentany1 2 μg/ml.The visual analog scale(VAS),Bromage motor scale score,cardiovascular variables and side effects were recorded within 48 hours after operation.Results: There was no significant difference in VAS scores;group R was lower in extremity locomotion blockage and was superior in muscle force recovery.Conclusions: PCEA with 0.15 ropivacaine containing fentanyl 2 μg/ml provides adequate pain relief after cesarean section with little noxious or side effects.
Objective: To compare the effects and side effects of ropivacaine and racemic bupiacaine in epidural analgesia after cesarean section.Methods: Fifty full-terms,nulliparous women undergoing cesarean section under eqidural anesthesia ware enrolled in this randomized double-blind study and were divided into ropivacaine group and racemic bupiacaine group.After operation,the patients were randomized to receive 1.5 ropivacaine(group R,n=25)or 0.125 bupivacaine(group B,n=25)for patient-controlled epidural analgesia(PCEA).The PCEA solution for the 2 groups contained fentany1 2 μg/ml.The visual analog scale(VAS),Bromage motor scale score,cardiovascular variables and side effects were recorded within 48 hours after operation.Results: There was no significant difference in VAS scores;group R was lower in extremity locomotion blockage and was superior in muscle force recovery.Conclusions: PCEA with 0.15 ropivacaine containing fentanyl 2 μg/ml provides adequate pain relief after cesarean section with little noxious or side effects.
2006, 31(6): 622-623.
Abstract:
Objective: To investigate the expression of cyclooxyenase-2(COX-2),vascular endothelial cell growth factor(VEGF) and cyclin D1 in gastric carcinoma and chronice atrophic gastritis and its significance.Methods: The expression of COX-2,VEGF and cyclin D1 in 60 cases of gastric carcinoma and 20 cases of chronic atrophic gastritis was studied by immunohistochemical method.Results: The positive rate of COX-2 was 66.67 in gastric carcinoma,which was higher than that in chronic atrophic gastritis(P<0.05).The positive rate of VEGF was76.67 in gastric carcinoma,which was higher than that in chronic atrophic gastritis(P<0.005).The positive rate of cyclin D1 was 61.67 in gastric carcinoma,which was significantly higher than that in chronic atrophic gastritis(P<0.005).Conclusions: The expression level of COX-2,VEGF and cyclin D1 may be closely correlated with the cancerous transformation process of chronic atrophic gastritis.
Objective: To investigate the expression of cyclooxyenase-2(COX-2),vascular endothelial cell growth factor(VEGF) and cyclin D1 in gastric carcinoma and chronice atrophic gastritis and its significance.Methods: The expression of COX-2,VEGF and cyclin D1 in 60 cases of gastric carcinoma and 20 cases of chronic atrophic gastritis was studied by immunohistochemical method.Results: The positive rate of COX-2 was 66.67 in gastric carcinoma,which was higher than that in chronic atrophic gastritis(P<0.05).The positive rate of VEGF was76.67 in gastric carcinoma,which was higher than that in chronic atrophic gastritis(P<0.005).The positive rate of cyclin D1 was 61.67 in gastric carcinoma,which was significantly higher than that in chronic atrophic gastritis(P<0.005).Conclusions: The expression level of COX-2,VEGF and cyclin D1 may be closely correlated with the cancerous transformation process of chronic atrophic gastritis.
2006, 31(6): 624-626.
Abstract:
Objective: To study the influence of neoadjuvant chemotherapy on tumor cell apoptosis and proliferation in patients with breast cancer.Methods: The apoptosis index(AI) of tumor cells in the neoadjuvant group and control group was assayed by TdT-mediated dUTP-biotin nick end labeling(TUNEL),and the Ki-67 antigen was examined by immunohistochemical method.Results: The AI of tumor cells was 9.26 in the neoadjuvant group and 3.36 in the control group.The difference was significant(P<0.01).The overexpression rate of Ki-67 antigen in the neoadjuvant group was 15.63,which was 50.0 lower than that in the control group(P<0.05). Conclusions: Neoadjuvant chemotherapy can induce tumor cell apoptosis and inhibit tumor cell proliferation in patients with breast cancer.
Objective: To study the influence of neoadjuvant chemotherapy on tumor cell apoptosis and proliferation in patients with breast cancer.Methods: The apoptosis index(AI) of tumor cells in the neoadjuvant group and control group was assayed by TdT-mediated dUTP-biotin nick end labeling(TUNEL),and the Ki-67 antigen was examined by immunohistochemical method.Results: The AI of tumor cells was 9.26 in the neoadjuvant group and 3.36 in the control group.The difference was significant(P<0.01).The overexpression rate of Ki-67 antigen in the neoadjuvant group was 15.63,which was 50.0 lower than that in the control group(P<0.05). Conclusions: Neoadjuvant chemotherapy can induce tumor cell apoptosis and inhibit tumor cell proliferation in patients with breast cancer.
2006, 31(6): 627-629.
Abstract:
Objective: To investigate the diagnosis and therapy value of laparoscope in the gynecologic acute abdomen.Methods: The retrospective analysis for 67 patients with gynecologic acute abdomen were performed based on the laparoscope and based on whether or not the patients who want babies.Excision of oviduct on the affected side plus the ligation of the oviduct on the healthy side were formed and at the same time the conservative operation on the oviduct,the ovariotomy and the conglutination release were performed.Results: All patients could be cured in time without complications.Conclusions: The treatment of the gynecological acute abdomen with laparoscope is significantly effective with short hospitalization time and less pains without more complications.So far it is the most effective for the gynecological abdomen,especially for the young patients who want babies.
Objective: To investigate the diagnosis and therapy value of laparoscope in the gynecologic acute abdomen.Methods: The retrospective analysis for 67 patients with gynecologic acute abdomen were performed based on the laparoscope and based on whether or not the patients who want babies.Excision of oviduct on the affected side plus the ligation of the oviduct on the healthy side were formed and at the same time the conservative operation on the oviduct,the ovariotomy and the conglutination release were performed.Results: All patients could be cured in time without complications.Conclusions: The treatment of the gynecological acute abdomen with laparoscope is significantly effective with short hospitalization time and less pains without more complications.So far it is the most effective for the gynecological abdomen,especially for the young patients who want babies.
2006, 31(6): 629-630.
Abstract:
Objective: To investigate the effect of sporanox,natamycin eye drops and antibiotics on mycotic keratitis.Methods: Eight patients with mild keratitis were treated only with sporanox.Twelve patients with middle,severe keratitis were treated with sporanox,natamycin eye drops,and antibiotics in combination.Results: Twenty patients with mycotic keratitis were all cured.Two patients with corneal ulcer and perforation were transplanted with conjunctival flap,the eyeball were all protected.Conclusions: The theraputic effects of combination of sporanox,natamycin eye drops,and antibiotics are of efficacy on mycotic keratitis.
Objective: To investigate the effect of sporanox,natamycin eye drops and antibiotics on mycotic keratitis.Methods: Eight patients with mild keratitis were treated only with sporanox.Twelve patients with middle,severe keratitis were treated with sporanox,natamycin eye drops,and antibiotics in combination.Results: Twenty patients with mycotic keratitis were all cured.Two patients with corneal ulcer and perforation were transplanted with conjunctival flap,the eyeball were all protected.Conclusions: The theraputic effects of combination of sporanox,natamycin eye drops,and antibiotics are of efficacy on mycotic keratitis.
2006, 31(6): 631-632.
Abstract:
Objective: To evaluate the effectiveness and safety of ureteroscopic holmium:YAG laser lithotripsy for managing ureteral calculi.Methods: Ureteroscopic holmium:YAG laser lithotripsy was used in 252 patients with ureteral calculi(proximal in 36 patients,middle in 86 and distal in 130 patients).Results: The stone-free rate was 88 in the patients with proximal ureteral calculi,91 in those with middle ureteral calculi and 95 in those with distal ureteral calculi respectively.The complications occurreded in 5.9(15/252) during and after the operation.Conclusions: Ureteroscopic holmimium:YAG laser lithotripsy is a highly effective and safe method for managing ureteral calculi.
Objective: To evaluate the effectiveness and safety of ureteroscopic holmium:YAG laser lithotripsy for managing ureteral calculi.Methods: Ureteroscopic holmium:YAG laser lithotripsy was used in 252 patients with ureteral calculi(proximal in 36 patients,middle in 86 and distal in 130 patients).Results: The stone-free rate was 88 in the patients with proximal ureteral calculi,91 in those with middle ureteral calculi and 95 in those with distal ureteral calculi respectively.The complications occurreded in 5.9(15/252) during and after the operation.Conclusions: Ureteroscopic holmimium:YAG laser lithotripsy is a highly effective and safe method for managing ureteral calculi.
2006, 31(6): 633-635.
Abstract:
Objective: To investigate the effect of the continued treatment(including pharmaceuticals and non-pharmaceuticals) on prognosis of newborn with hypoxic ischemic encephalopathy(HIE).Methods: One hundred and eight newborns with the middle and serious HIE were divided into the observation group(69 cases) and the control group(39 cases)(Group C).The observation group was further divided into Group A(37 cases) and Group B(32 cases).Group A and B underwent same early intervention.Group A was also administered with three courses of the pharmaceuticals cerebroprotein hydrolysate injection after the newborn stage.The newborns in the control group were brought up routinely.They were followed up at one month,six months and twelve months interval.MDI and PDI of the 3 groups were compared at twelve months interval.Results: MDI was 92.027±8.48,87.844±7.89 and 83.821±8.693 for Group A,B and C respectively.PDI was 93.216±9.096,88.500±8.474 and 84.231±9.068 for Group A,B and C respectively with significant differences(P<0.05~P<0.01)Conclusions: The continued treatment can improve HIE prognosis.The pharmaceuticals treatment combined with early intervention is better than the simple early intervention treat.
Objective: To investigate the effect of the continued treatment(including pharmaceuticals and non-pharmaceuticals) on prognosis of newborn with hypoxic ischemic encephalopathy(HIE).Methods: One hundred and eight newborns with the middle and serious HIE were divided into the observation group(69 cases) and the control group(39 cases)(Group C).The observation group was further divided into Group A(37 cases) and Group B(32 cases).Group A and B underwent same early intervention.Group A was also administered with three courses of the pharmaceuticals cerebroprotein hydrolysate injection after the newborn stage.The newborns in the control group were brought up routinely.They were followed up at one month,six months and twelve months interval.MDI and PDI of the 3 groups were compared at twelve months interval.Results: MDI was 92.027±8.48,87.844±7.89 and 83.821±8.693 for Group A,B and C respectively.PDI was 93.216±9.096,88.500±8.474 and 84.231±9.068 for Group A,B and C respectively with significant differences(P<0.05~P<0.01)Conclusions: The continued treatment can improve HIE prognosis.The pharmaceuticals treatment combined with early intervention is better than the simple early intervention treat.
2006, 31(6): 635-636.
Abstract:
Objective: To summarize the treatment of chylothorax complicated in radical operation for lung cancer.Methods: Eleven cases of chylothorax complicated in radical operation for lung cancer were diagnosed and confirmed by laboratory examination.Nine cases were given conservative treatment and 2 cases were performed surgical operation.Results: All the cases were cured.Two cases demonstrated pneumoserothorax,one case diabetes mellitus and one case hypertension.No chylothorax recurred during the 6-24 months follow-up.One case died from tardive bronchopleural fistula half a year later.Conclusions: The chylothorax complicated in radical operation for lung cancer can be cured by prompt diagnosis and treatment.
Objective: To summarize the treatment of chylothorax complicated in radical operation for lung cancer.Methods: Eleven cases of chylothorax complicated in radical operation for lung cancer were diagnosed and confirmed by laboratory examination.Nine cases were given conservative treatment and 2 cases were performed surgical operation.Results: All the cases were cured.Two cases demonstrated pneumoserothorax,one case diabetes mellitus and one case hypertension.No chylothorax recurred during the 6-24 months follow-up.One case died from tardive bronchopleural fistula half a year later.Conclusions: The chylothorax complicated in radical operation for lung cancer can be cured by prompt diagnosis and treatment.
2006, 31(6): 637-639.
Abstract:
Objective: To investigate the clinical effects of pelvic radiotherapy combined with cisplatin chemotherapy for treatment of stage Ⅲ cervical cancer.Methods: Ninety patients received pelvic radiotherapy combined with cisplatin chemotherapy while 74 patients underwent radiotherapy alone.Results: Five-year survival rates in chemo-radiotherapy group and in radiotherapy group were 60.0 and 43.2 respectively(P<0.05).Local control rates were 57.8 and 37.8 respectively(P<0.05).Distant metastasis rates were 35.6 and 33.8 respectively(P>0.05).Rectal complications were 11.1 and 10.8 respectively(P>0.05).Bladder complications were 6.7 and 6.8 respectively(P>0.05).There was no treatment mortality.Conclusions: The pelvic radiotherapy combined with cisplatin chemotherapy for treatment of stage Ⅲ cervical cancer can improve the local control rate and 5-year survival rate except the distant metastasis rate.Side effects can be alleviated.
Objective: To investigate the clinical effects of pelvic radiotherapy combined with cisplatin chemotherapy for treatment of stage Ⅲ cervical cancer.Methods: Ninety patients received pelvic radiotherapy combined with cisplatin chemotherapy while 74 patients underwent radiotherapy alone.Results: Five-year survival rates in chemo-radiotherapy group and in radiotherapy group were 60.0 and 43.2 respectively(P<0.05).Local control rates were 57.8 and 37.8 respectively(P<0.05).Distant metastasis rates were 35.6 and 33.8 respectively(P>0.05).Rectal complications were 11.1 and 10.8 respectively(P>0.05).Bladder complications were 6.7 and 6.8 respectively(P>0.05).There was no treatment mortality.Conclusions: The pelvic radiotherapy combined with cisplatin chemotherapy for treatment of stage Ⅲ cervical cancer can improve the local control rate and 5-year survival rate except the distant metastasis rate.Side effects can be alleviated.
2006, 31(6): 639-640.
Abstract:
Objective: To improve the understanding of breast milk jaunclice(BMJ) so as to make early diagnosis and treatment.Methods: Seventy-two confirmed BMJ neonates were observed and analyzed.The total bilirubin of seventy cases was greater than 221 μmol/L.The 22 cases whose total bilirubin was greater than 342 μmol/L were treated,on the basis of phototherapy,with Yinzhihuang,smecta and combined traditional Chinese and Western medicine to retreat yellowy, and breast-feed was suspended for 48- 72 hours.The other 48 cases whose total bilirubin were between 221 to 342 μmol/L were received the same therapy but continued to be breast-fed.Results: The serum bilirubin levels of 58(80.6)infants dropped to 50 of the original levels within 3 days.Conclusions: BMJ can cause high bilirubin blood disease.Timely Intervention can accelerate the disappearance of jaundice and the prognosis is good.
Objective: To improve the understanding of breast milk jaunclice(BMJ) so as to make early diagnosis and treatment.Methods: Seventy-two confirmed BMJ neonates were observed and analyzed.The total bilirubin of seventy cases was greater than 221 μmol/L.The 22 cases whose total bilirubin was greater than 342 μmol/L were treated,on the basis of phototherapy,with Yinzhihuang,smecta and combined traditional Chinese and Western medicine to retreat yellowy, and breast-feed was suspended for 48- 72 hours.The other 48 cases whose total bilirubin were between 221 to 342 μmol/L were received the same therapy but continued to be breast-fed.Results: The serum bilirubin levels of 58(80.6)infants dropped to 50 of the original levels within 3 days.Conclusions: BMJ can cause high bilirubin blood disease.Timely Intervention can accelerate the disappearance of jaundice and the prognosis is good.
2006, 31(6): 641-642.
Abstract:
Objective: To investigate the proper operation method for colorectal carcinoma associated with acute intestinal obstruction.Methods: The clinical data of 48 patients with colorectal carcinoma associated with acute intestinal obstruction undergoing the surgical treatment from 1997 to 2006 were retrospectivedly analyzed.Twenty-four patients underwent colectomy with one-stage anastomosis,16 colectomy and the same pluged anastomotic stoma out of peritoneal cavity or Hartmann operation,8 double-cavity colostomy or by-pass.Results: Twenty-two patients experienced postoperative complications (45.8),including lung infection in 10 patients,wound infection in 8,peritoneal cavity infection in 2 and disruption of wound in 2.The perioperative mortality was 8.3 (4/48).Conclusions: Under the probable conditions,colectomy with one-stage anatomasis should be performed first.The active preoperative preparation and intensive postoperative treatment,the correct operation methods are important for reducing morbidity and mortality.
Objective: To investigate the proper operation method for colorectal carcinoma associated with acute intestinal obstruction.Methods: The clinical data of 48 patients with colorectal carcinoma associated with acute intestinal obstruction undergoing the surgical treatment from 1997 to 2006 were retrospectivedly analyzed.Twenty-four patients underwent colectomy with one-stage anastomosis,16 colectomy and the same pluged anastomotic stoma out of peritoneal cavity or Hartmann operation,8 double-cavity colostomy or by-pass.Results: Twenty-two patients experienced postoperative complications (45.8),including lung infection in 10 patients,wound infection in 8,peritoneal cavity infection in 2 and disruption of wound in 2.The perioperative mortality was 8.3 (4/48).Conclusions: Under the probable conditions,colectomy with one-stage anatomasis should be performed first.The active preoperative preparation and intensive postoperative treatment,the correct operation methods are important for reducing morbidity and mortality.
2006, 31(6): 655-656.
Abstract:
Objective: To study the effects of incremental load training on exercise capacity by establishing exercise fatigue model.Methods: The maximal oxygen uptake (VO2 max)and physical working capacity(PWC170)were measured at five-week incremental exercise training protocol.Results: With exercise loads increasing,compared to preexercise,maximal oxygen uptake of exercise group elevated(P<0.05),while control group had no change(P>0.05).PWC170 increased week by week.Conclusions: During five-week incremental load training,exercise capacity is raised as a result of adaptability.
Objective: To study the effects of incremental load training on exercise capacity by establishing exercise fatigue model.Methods: The maximal oxygen uptake (VO2 max)and physical working capacity(PWC170)were measured at five-week incremental exercise training protocol.Results: With exercise loads increasing,compared to preexercise,maximal oxygen uptake of exercise group elevated(P<0.05),while control group had no change(P>0.05).PWC170 increased week by week.Conclusions: During five-week incremental load training,exercise capacity is raised as a result of adaptability.
2006, 31(6): 657-659.
Abstract:
Objective: To explore the affecting factors of intelligence on middle school students.Methods: Intelligence quotients(IQ) of 198 middle school students were measured with Wechsler intelligence Scale for Children-Revised(WISC-R) and the factors that affect IQ were analysed.Results: IQ distribution in these students was normal.There was no sexual difference in the verbal intelligence quotient(VIQ),performance intelligence(PIQ) and full intelligence quotient(FIQ)(P>0.05).The intelligence of student that had a hobby was higher than that of student without a hobby(P<0.01).There was obvious difference in IQ of differ school's student(P<0.05).Through multilane regress,factors of affecting IQ include hobby,mother's and father's education level,father's job,school and age.Conclusions: That raising parents' education level and training children's hobby are significant for the development of middle school students' intelligence.
Objective: To explore the affecting factors of intelligence on middle school students.Methods: Intelligence quotients(IQ) of 198 middle school students were measured with Wechsler intelligence Scale for Children-Revised(WISC-R) and the factors that affect IQ were analysed.Results: IQ distribution in these students was normal.There was no sexual difference in the verbal intelligence quotient(VIQ),performance intelligence(PIQ) and full intelligence quotient(FIQ)(P>0.05).The intelligence of student that had a hobby was higher than that of student without a hobby(P<0.01).There was obvious difference in IQ of differ school's student(P<0.05).Through multilane regress,factors of affecting IQ include hobby,mother's and father's education level,father's job,school and age.Conclusions: That raising parents' education level and training children's hobby are significant for the development of middle school students' intelligence.
2006, 31(6): 660-662.
Abstract:
Objective: To investigate the bacterial contamination and endotoxin in hemodialysis fluid.Methods: The levels of bacterial contamination were detected by pour plate method.The species of bacteria were evaluated by routine method and the endotoxin was detected by gel-colt assay with limulus reagents.Results: The average bacteria colony forming unit per milliliter in reverse osmosis and dialysis fluid from the dialyzer inlet,outlet,fluid A,and fluid B was 130 CFU/ml,259 CFU/ml,644 CFU/ml,13 CFU/ml,and 268 CFU/ml,respectively.The positive rate of endotoxin was 5.8 in reverse osmosis.The common isolated bacteria were Gram-negative bacilli(nonferments was main),Gram-positive bacilli and coccus.From April to October,the average number of colony exceeded the same kind of sample in the same year.Conclusions: Many factors such as the process of production,transportation and recycling use of reverse osmosis and the process of preparation and reservation of dialysis fluid may cause bacterial contamination,and is related to the seasons.Strict monitoring of dialysis fluid should be emphasized.
Objective: To investigate the bacterial contamination and endotoxin in hemodialysis fluid.Methods: The levels of bacterial contamination were detected by pour plate method.The species of bacteria were evaluated by routine method and the endotoxin was detected by gel-colt assay with limulus reagents.Results: The average bacteria colony forming unit per milliliter in reverse osmosis and dialysis fluid from the dialyzer inlet,outlet,fluid A,and fluid B was 130 CFU/ml,259 CFU/ml,644 CFU/ml,13 CFU/ml,and 268 CFU/ml,respectively.The positive rate of endotoxin was 5.8 in reverse osmosis.The common isolated bacteria were Gram-negative bacilli(nonferments was main),Gram-positive bacilli and coccus.From April to October,the average number of colony exceeded the same kind of sample in the same year.Conclusions: Many factors such as the process of production,transportation and recycling use of reverse osmosis and the process of preparation and reservation of dialysis fluid may cause bacterial contamination,and is related to the seasons.Strict monitoring of dialysis fluid should be emphasized.
2006, 31(6): 663-665.
Abstract:
Objective: To explore the influence of psychological intervention on the quality of life of patients with breast cancer.Methods: One hundred and twenty breast cancer patients were randomly divided into intervention and control groups.The clinical psychological intervention was performed on patients in intervention groups for 20 days,and just the routine therapy and care were performed on patients in control groups.World Health Organization Quality of Life with 100 questions(WHOQLQ-100) was used to observe the influence of psychological intervention on the quality of life of breast cancer patients.Results: The quality of life in intervention groups was obviously higher than that in control groups(P<0.05~P<0.01).Conclusions: The quality of life in breast cancer patients will increase evidently after receiving the psychological intervention.
Objective: To explore the influence of psychological intervention on the quality of life of patients with breast cancer.Methods: One hundred and twenty breast cancer patients were randomly divided into intervention and control groups.The clinical psychological intervention was performed on patients in intervention groups for 20 days,and just the routine therapy and care were performed on patients in control groups.World Health Organization Quality of Life with 100 questions(WHOQLQ-100) was used to observe the influence of psychological intervention on the quality of life of breast cancer patients.Results: The quality of life in intervention groups was obviously higher than that in control groups(P<0.05~P<0.01).Conclusions: The quality of life in breast cancer patients will increase evidently after receiving the psychological intervention.
2006, 31(6): 665-667.
Abstract:
Objective: To investigate the nursing strategy of patients after pneumonectomy.Methods: Twenty-six patients underwent pneumonectomy comprising 24 patients with pulmonary carcinoma,one patient with pulmonary tuberculosis and one with destructed pulmonary function respectively.Results: Nineteen underwent left pneumonectomy and seven right pneumonectomy.Postoperative hemorrhage occurred in one patient and reoperation was performed.Bronchopleural fistula occurred in one patient,severe arrhythmia in four patients and hypoxia in six patients.Twenty-five recovered completely.Unfortunately,one patient gave up because of arrhythmia companied by hypoxia.Conclusions: Emphasis on the care of the patient after pneumonectomy will guarantee recovery of these patients.
Objective: To investigate the nursing strategy of patients after pneumonectomy.Methods: Twenty-six patients underwent pneumonectomy comprising 24 patients with pulmonary carcinoma,one patient with pulmonary tuberculosis and one with destructed pulmonary function respectively.Results: Nineteen underwent left pneumonectomy and seven right pneumonectomy.Postoperative hemorrhage occurred in one patient and reoperation was performed.Bronchopleural fistula occurred in one patient,severe arrhythmia in four patients and hypoxia in six patients.Twenty-five recovered completely.Unfortunately,one patient gave up because of arrhythmia companied by hypoxia.Conclusions: Emphasis on the care of the patient after pneumonectomy will guarantee recovery of these patients.
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