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2013 Vol. 38, No. 4
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2013, 37(4): 381-383.
Abstract:
Objective:To observe the expression change of calmodulin kinaseⅡ(CaMK Ⅱ)in infra-limbic cortex of medial prefrontal cortex of adult rats in the early stage of fear extinction.Methods:Seventy rats were randomly divided into normal control,fear extinction and fear control group.The fear extinction training was not implemented in fear control group.The fear extinction group were trained to extinct fear with sound signal at 24 hours after fear established by sound hint of planter electric shock.The expressions of CaMK Ⅱ in infra-limbic cortex were detected by immunohistochemistry at 1,3 and 7 days after fear extinction.Results:The expression of CaMK Ⅱ in fear extinction and fear control group increased gradually,which was lower than that in normal control group.The fear extinction group were better than that in fear control group(P0.01).The immunoreactivities of CaMK Ⅱin infra-limbic cortex of fear extinction and fear control group increased gradually,which were lower than that in normal control group.The immunoreactivities of CaMK Ⅱ in fear extinction group were lower than that in fear control group at 3 and 7 days after fear extinction(P0.01),but no significant difference at day 1.Conclusions:The CaMK Ⅱ level in infra-limbic cortex is consistent with the extinction memory at 3 and 7 days after fear extinction training.
Objective:To observe the expression change of calmodulin kinaseⅡ(CaMK Ⅱ)in infra-limbic cortex of medial prefrontal cortex of adult rats in the early stage of fear extinction.Methods:Seventy rats were randomly divided into normal control,fear extinction and fear control group.The fear extinction training was not implemented in fear control group.The fear extinction group were trained to extinct fear with sound signal at 24 hours after fear established by sound hint of planter electric shock.The expressions of CaMK Ⅱ in infra-limbic cortex were detected by immunohistochemistry at 1,3 and 7 days after fear extinction.Results:The expression of CaMK Ⅱ in fear extinction and fear control group increased gradually,which was lower than that in normal control group.The fear extinction group were better than that in fear control group(P0.01).The immunoreactivities of CaMK Ⅱin infra-limbic cortex of fear extinction and fear control group increased gradually,which were lower than that in normal control group.The immunoreactivities of CaMK Ⅱ in fear extinction group were lower than that in fear control group at 3 and 7 days after fear extinction(P0.01),but no significant difference at day 1.Conclusions:The CaMK Ⅱ level in infra-limbic cortex is consistent with the extinction memory at 3 and 7 days after fear extinction training.
2013, 37(4): 384-388.
Abstract:
Objective:To explore the correlation of the drug susceptibility of gefitinib-resistant in non-small cell lung cancer(NSCLS) induced by T790M mutation in EGFR and signal transducers and activators of transcription 3(STAT3).Methods:H1975 and PC9 cells were dealed with different concentrations of STAT3 specific inhibitor JSI-124.The inhibition rate of cells and the levels of protein and mRNA of relative factors were determined by CCK-8,Western blot and RT-PCR,respectirely.Results:The STAT3 expression of H1975 cells with EGFR T790M mutation of NSCLC were obviously higher than that in PC9 cells(P0.01).JSI-124 inhibited the activity of STAT3 in H1975 mutation cells in dose-and time-dependent manner and improved the susceptibility of gefitinib,but not for PC9 cells.Conclusions:The gefitinib-resistant mechanism induced by T790M mutation in EGFR is related to STAT3,which can be reversed by inhibiting the STAT3 activity.
Objective:To explore the correlation of the drug susceptibility of gefitinib-resistant in non-small cell lung cancer(NSCLS) induced by T790M mutation in EGFR and signal transducers and activators of transcription 3(STAT3).Methods:H1975 and PC9 cells were dealed with different concentrations of STAT3 specific inhibitor JSI-124.The inhibition rate of cells and the levels of protein and mRNA of relative factors were determined by CCK-8,Western blot and RT-PCR,respectirely.Results:The STAT3 expression of H1975 cells with EGFR T790M mutation of NSCLC were obviously higher than that in PC9 cells(P0.01).JSI-124 inhibited the activity of STAT3 in H1975 mutation cells in dose-and time-dependent manner and improved the susceptibility of gefitinib,but not for PC9 cells.Conclusions:The gefitinib-resistant mechanism induced by T790M mutation in EGFR is related to STAT3,which can be reversed by inhibiting the STAT3 activity.
2013, 37(4): 389-391.
Abstract:
Objective:To observe the influence of ceftriaxone on brain edema after cerebral ischemia-reperfusion in rats.Methods:Twenty-four male Sprague-Dawley rats were randomly divided into sham-operation group,control group and preconditioning group(ni=8).Focal cerebral ischemia was produced by introduction of an intraluminal nylon.The average signal intensity and the relative aparent diffusion coefficient were monitored with T2WI,enhanced T1WI and diffusion weighted imaging.The infarction volume was monitored with T2WI.Results:The infarction volume was decreased in preconditioning group,compared with control group,the difference was significant.Compared with control group,the relative aparent diffusion coefficient in preconditioning group was increased obviously.The relative signal intensity of the enhanced T1WI and T2WI was decreased in preconditioning group.The difference between preconditioning group and control group was significant.Conclusions:Ceftriaxone can ameliorate brain edema after cerebral ischemia-reperfusion to some degree.
Objective:To observe the influence of ceftriaxone on brain edema after cerebral ischemia-reperfusion in rats.Methods:Twenty-four male Sprague-Dawley rats were randomly divided into sham-operation group,control group and preconditioning group(ni=8).Focal cerebral ischemia was produced by introduction of an intraluminal nylon.The average signal intensity and the relative aparent diffusion coefficient were monitored with T2WI,enhanced T1WI and diffusion weighted imaging.The infarction volume was monitored with T2WI.Results:The infarction volume was decreased in preconditioning group,compared with control group,the difference was significant.Compared with control group,the relative aparent diffusion coefficient in preconditioning group was increased obviously.The relative signal intensity of the enhanced T1WI and T2WI was decreased in preconditioning group.The difference between preconditioning group and control group was significant.Conclusions:Ceftriaxone can ameliorate brain edema after cerebral ischemia-reperfusion to some degree.
2013, 37(4): 392-394.
Abstract:
Objective:To analyze the spatially genetic structure of FGA and D5S818 loci of Autosome in 87 Chinese and provide the molecular biology basis for exploring Chinese origin，migration，archaeology and ethnic diversity． Methods:Aggregative indicators were obtained from gene frequency matrix and spatially genetic structure of two short tandem repeat(STR) loci were investigated under visualization by principle component analysis and spatial data analysis of geographical information system． Results:The spatially genetic structure of FGA and D5S818 loci in Chinese could be divided into four large areas，which showed increasing trend from southeastern to northwestern and southwestern area． Conclusions:The spatially genetic structures of two STR loci have evidently genetic variability gradient in different region and crowd．
Objective:To analyze the spatially genetic structure of FGA and D5S818 loci of Autosome in 87 Chinese and provide the molecular biology basis for exploring Chinese origin，migration，archaeology and ethnic diversity． Methods:Aggregative indicators were obtained from gene frequency matrix and spatially genetic structure of two short tandem repeat(STR) loci were investigated under visualization by principle component analysis and spatial data analysis of geographical information system． Results:The spatially genetic structure of FGA and D5S818 loci in Chinese could be divided into four large areas，which showed increasing trend from southeastern to northwestern and southwestern area． Conclusions:The spatially genetic structures of two STR loci have evidently genetic variability gradient in different region and crowd．
2013, 37(4): 395-396,400.
Abstract:
Objective:To compare the clinical effects of the minimally invasive method with hammer chisel crown method in the extraction of mandible impacted wisdom tooth.Methods:Two hundred and sixty-nine cases with mandibular impacted wisdom tooth were randomly divided into the observation group(138 cases) and the control group(131 cases).The observation and control group were treated with minimally invasive extraction method and hammer chisel crown method,respectively.The operation time,the intraoperative and postoperative complications of two groups were observed and compared.Results:The operation time of the observation group was significantly shorter than that of the control group(P0.01).The intraoperative and postoperative complications of the observation group were significantly less than that of the control group(P0.05 to P0.01).Conclusions:The minimally invasive extraction method in the treatment of mandibular impacted wisdom tooth is short operation time and few intraoperative and postoperative complications,which has worth using in clinic.
Objective:To compare the clinical effects of the minimally invasive method with hammer chisel crown method in the extraction of mandible impacted wisdom tooth.Methods:Two hundred and sixty-nine cases with mandibular impacted wisdom tooth were randomly divided into the observation group(138 cases) and the control group(131 cases).The observation and control group were treated with minimally invasive extraction method and hammer chisel crown method,respectively.The operation time,the intraoperative and postoperative complications of two groups were observed and compared.Results:The operation time of the observation group was significantly shorter than that of the control group(P0.01).The intraoperative and postoperative complications of the observation group were significantly less than that of the control group(P0.05 to P0.01).Conclusions:The minimally invasive extraction method in the treatment of mandibular impacted wisdom tooth is short operation time and few intraoperative and postoperative complications,which has worth using in clinic.
2013, 37(4): 397-400.
Abstract:
Objective:To investigate the expressions of Delta-like ligand 4(DLL4) and vascular endothelial growth factor(VEGF) in non-small cell lung cancer(NSCLC) and normal lung specimens taken from non-cancerous regions adjacent to lung cancer tissue and analyze their correlation with clinical pathological factors as well as explore the role of them in the occurrence and development of NSCLC.Methods:The expressions of DLL4 and VEGF in 73 cases of NSCLC tissue and 32 cases of normal lung specimens taken from non-cancerous regions adjacent to lung cancer tissue were examined by EliVision immunohistochemistry method.Results:The positive rate of DLL4 and VEGF in NSCLC were significantly higher than those in adjacent normal lung tissue.In NSCLC tissues,the expressions of DLL4 and VEGF were closely related to TNM stage,lymph node metastasis(except DLL4) and histological grade(P0.05 to P0.01),but not to gender,age and histological type(P0.05).A positive correlation was observed between the expressions of DLL4 and VEGF(P0.05).Conclusions:The positive correlation between high-expressions of DLL4 and VEGF suggested that they might co-participate in the invasion/metastasis and prognosis of NSCLC through interacting with each other.DLL4 and VEGF may serve as a new therapeutic target of NSCLC patients.
Objective:To investigate the expressions of Delta-like ligand 4(DLL4) and vascular endothelial growth factor(VEGF) in non-small cell lung cancer(NSCLC) and normal lung specimens taken from non-cancerous regions adjacent to lung cancer tissue and analyze their correlation with clinical pathological factors as well as explore the role of them in the occurrence and development of NSCLC.Methods:The expressions of DLL4 and VEGF in 73 cases of NSCLC tissue and 32 cases of normal lung specimens taken from non-cancerous regions adjacent to lung cancer tissue were examined by EliVision immunohistochemistry method.Results:The positive rate of DLL4 and VEGF in NSCLC were significantly higher than those in adjacent normal lung tissue.In NSCLC tissues,the expressions of DLL4 and VEGF were closely related to TNM stage,lymph node metastasis(except DLL4) and histological grade(P0.05 to P0.01),but not to gender,age and histological type(P0.05).A positive correlation was observed between the expressions of DLL4 and VEGF(P0.05).Conclusions:The positive correlation between high-expressions of DLL4 and VEGF suggested that they might co-participate in the invasion/metastasis and prognosis of NSCLC through interacting with each other.DLL4 and VEGF may serve as a new therapeutic target of NSCLC patients.
2013, 37(4): 401-404.
Abstract:
Objective:To study the clinicopathological characteristics,diagnosis and prognose of secretory carcinoma of the breast.Methods:Microscopy,histochemical and immunohistochemical staining were used with the review of the literature to 2 cases secretory carcinoma of breast.Results:The tumor revealed small atypia of cancer cells and appeared large amounts of intracellular and extracellular eosinophilic PAS-positive secretory material.It constantly expressed immunhistochemical mark S-100.Conclusions:Secretory carcinoma of the breast is a rare breast carcinoma and has better prognosis.Combined with histological features and histochemical staining,diagnosis of secretory carcinoma of the breast also needs differential diagnosis of some tumors.
Objective:To study the clinicopathological characteristics,diagnosis and prognose of secretory carcinoma of the breast.Methods:Microscopy,histochemical and immunohistochemical staining were used with the review of the literature to 2 cases secretory carcinoma of breast.Results:The tumor revealed small atypia of cancer cells and appeared large amounts of intracellular and extracellular eosinophilic PAS-positive secretory material.It constantly expressed immunhistochemical mark S-100.Conclusions:Secretory carcinoma of the breast is a rare breast carcinoma and has better prognosis.Combined with histological features and histochemical staining,diagnosis of secretory carcinoma of the breast also needs differential diagnosis of some tumors.
2013, 37(4): 404-406.
Abstract:
Objective:To analyze the serum resistin levels and the correlated factors in three kinds of prediabetes patients.Methods:The fasting serum level of the resistin was examined in patients with impaired fasting glucose(IFG),impaired glucose tolerance(IGT),IGT combined with IFG and in people with normal blood glucose(NBG)(ni=50).The results were compared and analyzed.Results:The fasting serum resistin concentration in the IGT,IFG and IGT+IFG groups was significantly higher than that in the NBG group(P0.01),the difference was not significant between the IFG group and the IGT group(P0.05),the serum resistin level was higher in the IGT+IFG group than that in the IFG and the IGT groups(P0.01 and P0.05).The logistic regression analysis showed that the fasting resistin level was strongly correlated with the fasting serum glucose,fasting serum insulin,body mass index and the waist circumference.Conclusions:The fasting serum resistin concentration in the three kinds of prediabetes patients is higher than that in the NBG group.The fasting resistin level is strongly correlated with the fasting serum glucose,fasting serum insulin,body mass index and the waist circumference.
Objective:To analyze the serum resistin levels and the correlated factors in three kinds of prediabetes patients.Methods:The fasting serum level of the resistin was examined in patients with impaired fasting glucose(IFG),impaired glucose tolerance(IGT),IGT combined with IFG and in people with normal blood glucose(NBG)(ni=50).The results were compared and analyzed.Results:The fasting serum resistin concentration in the IGT,IFG and IGT+IFG groups was significantly higher than that in the NBG group(P0.01),the difference was not significant between the IFG group and the IGT group(P0.05),the serum resistin level was higher in the IGT+IFG group than that in the IFG and the IGT groups(P0.01 and P0.05).The logistic regression analysis showed that the fasting resistin level was strongly correlated with the fasting serum glucose,fasting serum insulin,body mass index and the waist circumference.Conclusions:The fasting serum resistin concentration in the three kinds of prediabetes patients is higher than that in the NBG group.The fasting resistin level is strongly correlated with the fasting serum glucose,fasting serum insulin,body mass index and the waist circumference.
2013, 37(4): 407-409.
Abstract:
Objective:To evaluate the efficacy and safety of fractionated stereotactic radiotherapy(FSRT) in the treatment of lung metastatic tumors.Methods:Thirty-one cases(1 to 3 lesions each case) were treated with FSRT.Single target dose of surrounding area was from 3 to 5 Gy,which total radiation dose was from 30 to 45Gy through 7 to 9 times completing.The 50% of dosage curve covered the planning target volume.Results:Up to Dec.2011,25 patients died.The median overall survival was 20.7 months(3.5 to 42.9 months),the overall survival rates of 1 year and 2 years were 78.4% and 43.2%,respectively.The clinical symptoms remission and local tumor control rates of all patients were 84.1% and 90.4%,respectively.The differences of the survival rate of patients with pulmonary lesions and no pulmonary lesions were significant(P=0.043).The effective rates of squamous carcinoma and adenocarcinoma were 83.3%(10/12) and 85.7%(12/14),respectively.The effective rates of cancer derived from epithelium and no epithelium were 84.6% and 3/3,respectively,which differences were not significant(P=1.000).Conclusions:FSRT in the treatment of lung metastasis is effective and safe,which can prolong the survival under strict mastering indications.The prognosis of patient with single and no pulmonary metastasis is good.
Objective:To evaluate the efficacy and safety of fractionated stereotactic radiotherapy(FSRT) in the treatment of lung metastatic tumors.Methods:Thirty-one cases(1 to 3 lesions each case) were treated with FSRT.Single target dose of surrounding area was from 3 to 5 Gy,which total radiation dose was from 30 to 45Gy through 7 to 9 times completing.The 50% of dosage curve covered the planning target volume.Results:Up to Dec.2011,25 patients died.The median overall survival was 20.7 months(3.5 to 42.9 months),the overall survival rates of 1 year and 2 years were 78.4% and 43.2%,respectively.The clinical symptoms remission and local tumor control rates of all patients were 84.1% and 90.4%,respectively.The differences of the survival rate of patients with pulmonary lesions and no pulmonary lesions were significant(P=0.043).The effective rates of squamous carcinoma and adenocarcinoma were 83.3%(10/12) and 85.7%(12/14),respectively.The effective rates of cancer derived from epithelium and no epithelium were 84.6% and 3/3,respectively,which differences were not significant(P=1.000).Conclusions:FSRT in the treatment of lung metastasis is effective and safe,which can prolong the survival under strict mastering indications.The prognosis of patient with single and no pulmonary metastasis is good.
2013, 37(4): 410-411,414.
Abstract:
Objective:To explore the clinical characteristics of children asthma caused by infection of Mycoplasma pneumonia(MP) and treatment effect of such diseases.Methods:The clinical data of 74 cases diagnosed as asthma were analyzed retrospectively from 2009 to 2011.Thirty-six cases were diagnosed as asthma caused by infection of MP(infection of MP group) and 38 cases of asthma caused by non-infection of MP(non-infection of MP group).The patients'fever,cough,wheezing characteristics,lungs' function,organs involved extra pulmonary organs,therapies and the treatment responses to bronchodilators were observed.Results:The two groups showed statistical differences in the measures of fever,wheezing characteristics,lungs'function and the treatment responses to bronchodilators(P0.05-P0.01).The incidence of lung involvement was not statistically significant(P0.05).Macrolide antibiotics must be used in the children asthma caused by infection of MP.Conclusions:Compared with non-infection of MP group,infection of MP group has more fever,severe cough with late wheezing for a long time and insensitivity to bronchodilators.The use of macrolide antibiotics along with bronchodilators and inhaled corti-costeroids is effective in the treatment.
Objective:To explore the clinical characteristics of children asthma caused by infection of Mycoplasma pneumonia(MP) and treatment effect of such diseases.Methods:The clinical data of 74 cases diagnosed as asthma were analyzed retrospectively from 2009 to 2011.Thirty-six cases were diagnosed as asthma caused by infection of MP(infection of MP group) and 38 cases of asthma caused by non-infection of MP(non-infection of MP group).The patients'fever,cough,wheezing characteristics,lungs' function,organs involved extra pulmonary organs,therapies and the treatment responses to bronchodilators were observed.Results:The two groups showed statistical differences in the measures of fever,wheezing characteristics,lungs'function and the treatment responses to bronchodilators(P0.05-P0.01).The incidence of lung involvement was not statistically significant(P0.05).Macrolide antibiotics must be used in the children asthma caused by infection of MP.Conclusions:Compared with non-infection of MP group,infection of MP group has more fever,severe cough with late wheezing for a long time and insensitivity to bronchodilators.The use of macrolide antibiotics along with bronchodilators and inhaled corti-costeroids is effective in the treatment.
2013, 37(4): 412-414.
Abstract:
Objective:To investigate the efficacy of low dose of prednisone combined with aspirin on recurrent spontaneous abortion(RSA).Methods:Fifty-three cases of RSA were randomly divided into treatment group(33 cases) and control group(20 cases).The cases in the treatment group were administered low dose of prednisone 100 mg once each day and aspirin 5 mg once every night for 3 months;3 months later,the dosage of aspirin was decreased to 25 mg and prednisone to 2.5 mg once every night.The therapy was carried out until 3 months after pregnancy;the controls were given the routine therapy of progesterone only.The therapy was regarded as effective when the fetal in utero was alive or presenting no fetal disorder at 28 weeks of gestation.The treatment efficacy,the live birth rate and the incidence of pregnancy-coexisted diseases were compared between the two groups.Results:The efficacy rate in the treatment group was significantly higher than that in the control(P0.01)and low dose of aspirin and prednisone would not increase the incidence of pregnancy-coexisted diseases.Conclusions:The therapy of low dose of prednisone combined with aspirin can effectively prevent the incidence of RSA and is highly feasible in clinical application.
Objective:To investigate the efficacy of low dose of prednisone combined with aspirin on recurrent spontaneous abortion(RSA).Methods:Fifty-three cases of RSA were randomly divided into treatment group(33 cases) and control group(20 cases).The cases in the treatment group were administered low dose of prednisone 100 mg once each day and aspirin 5 mg once every night for 3 months;3 months later,the dosage of aspirin was decreased to 25 mg and prednisone to 2.5 mg once every night.The therapy was carried out until 3 months after pregnancy;the controls were given the routine therapy of progesterone only.The therapy was regarded as effective when the fetal in utero was alive or presenting no fetal disorder at 28 weeks of gestation.The treatment efficacy,the live birth rate and the incidence of pregnancy-coexisted diseases were compared between the two groups.Results:The efficacy rate in the treatment group was significantly higher than that in the control(P0.01)and low dose of aspirin and prednisone would not increase the incidence of pregnancy-coexisted diseases.Conclusions:The therapy of low dose of prednisone combined with aspirin can effectively prevent the incidence of RSA and is highly feasible in clinical application.
2013, 37(4): 415-417.
Abstract:
Objective:To analyze the variable coefficient difference of red blood cell distribution width(RDW) in different stage of elderly people essential hypertension and investigate the correlation between the level of essential hypertension and RDW.Methods:The levels of systolic blood pressure,diastolic blood pressure,RDW,blood urea nitrogen,uric acid,blood lipid and homocysteine of 191 senile patients with stage 1,2 and 3 essential hypertension were measured and analysed.Fifty-nine healthy people acted as the control group.The correlation between different hypertension level and the variable coefficient of RDW was investigated using linear correlation analysis and multiple linear stepwise regression.Results:There was not statistical significance in the variable coefficient difference of RDW of different stage hypertension(P0.05).The variable coefficient of RDW was positively related with systolic blood pressure.Multiple linear regression analysis showed that systolic blood pressure was a influencng factor of the variable coefficient of RDW(=0.351,P=0.002).Conclusions:The variable coefficient of RDW is not significant difference in different stage hypertension,which is positively related with systolic blood pressure.
Objective:To analyze the variable coefficient difference of red blood cell distribution width(RDW) in different stage of elderly people essential hypertension and investigate the correlation between the level of essential hypertension and RDW.Methods:The levels of systolic blood pressure,diastolic blood pressure,RDW,blood urea nitrogen,uric acid,blood lipid and homocysteine of 191 senile patients with stage 1,2 and 3 essential hypertension were measured and analysed.Fifty-nine healthy people acted as the control group.The correlation between different hypertension level and the variable coefficient of RDW was investigated using linear correlation analysis and multiple linear stepwise regression.Results:There was not statistical significance in the variable coefficient difference of RDW of different stage hypertension(P0.05).The variable coefficient of RDW was positively related with systolic blood pressure.Multiple linear regression analysis showed that systolic blood pressure was a influencng factor of the variable coefficient of RDW(=0.351,P=0.002).Conclusions:The variable coefficient of RDW is not significant difference in different stage hypertension,which is positively related with systolic blood pressure.
2013, 37(4): 418-420.
Abstract:
Objective:To compare the clinical efficacy of emergency and selective operation in the treatment of Pilon fracture for providing the basis of clinical operation.Methods:One hundred and thirty-eight patients with Pilon fractures were treated with emergency or selective operation from Feb.2005 to Mar.2011.Fourty-nine patients were treated with emergency operation within 12 hours after injury,89 patients were treated with selective operation at 7 days after injury.The operation time,blood loss,length of stay,hospitalization expense,postoperative complication,ankle jiont functional recovery of two groups were compared.Results:All patients were followed up for 9 to 36 months.The operation time,length of stay and hospitalization expense in emergency operation group were significantly less than those in selective operation group(P0.01),but its blood loss was more.There were not statistically significant differences in wound infection and necrosis,lower limb deep vein thrombus,the long-term complications(such as nonunion or delayed union of fracture),osteoarthritis and the incidence of ankle joint stiffness between the two groups(P0.05).The Mazur scores of ankle joint function in two groups had no statistically significant difference in 22 months after operation(P0.05).Conclusions:The postoperative complication incidence of emergency operation in the treatment of Pilon fracture is not higher than that in selective operation,which can shorten the length of stay,decrease the hospitalization expense and promote early functional rehabilitation.
Objective:To compare the clinical efficacy of emergency and selective operation in the treatment of Pilon fracture for providing the basis of clinical operation.Methods:One hundred and thirty-eight patients with Pilon fractures were treated with emergency or selective operation from Feb.2005 to Mar.2011.Fourty-nine patients were treated with emergency operation within 12 hours after injury,89 patients were treated with selective operation at 7 days after injury.The operation time,blood loss,length of stay,hospitalization expense,postoperative complication,ankle jiont functional recovery of two groups were compared.Results:All patients were followed up for 9 to 36 months.The operation time,length of stay and hospitalization expense in emergency operation group were significantly less than those in selective operation group(P0.01),but its blood loss was more.There were not statistically significant differences in wound infection and necrosis,lower limb deep vein thrombus,the long-term complications(such as nonunion or delayed union of fracture),osteoarthritis and the incidence of ankle joint stiffness between the two groups(P0.05).The Mazur scores of ankle joint function in two groups had no statistically significant difference in 22 months after operation(P0.05).Conclusions:The postoperative complication incidence of emergency operation in the treatment of Pilon fracture is not higher than that in selective operation,which can shorten the length of stay,decrease the hospitalization expense and promote early functional rehabilitation.
The pathological and differential diagnosis of pancreatic endocrine tumor with acinar cell carcinoma
2013, 37(4): 421-423,426.
Abstract:
Objective:To explore the clinicopathologic features and differential diagnosis of pancreatic endocrine tumor(PET).Methods:The clinicopathologic and immunohistochemical features of 3 PET were analysed.Combined with the literatures,the diagnosis of pancreatic acinar cell carcinoma were identified.Results:The PET cells were solid flake and trabecular shape,acinar-like arrangement and not significant cellular atypia,and rich blood vessels in intercellular substance.Chromogranin A,synaptophysin,and the endocrine markers of insulin were detected by immunohistochemistry.Conclusions:Most PET are benign,but the pancreatic acinar cell carcinoma is highly invasive tumor.The morphology of the pancreatic acinar cell carcinoma is similar to the PET,and the biological behaviors of two types tumor have significantly different,and distinguishing two types of famor has obvious clinical significance.
Objective:To explore the clinicopathologic features and differential diagnosis of pancreatic endocrine tumor(PET).Methods:The clinicopathologic and immunohistochemical features of 3 PET were analysed.Combined with the literatures,the diagnosis of pancreatic acinar cell carcinoma were identified.Results:The PET cells were solid flake and trabecular shape,acinar-like arrangement and not significant cellular atypia,and rich blood vessels in intercellular substance.Chromogranin A,synaptophysin,and the endocrine markers of insulin were detected by immunohistochemistry.Conclusions:Most PET are benign,but the pancreatic acinar cell carcinoma is highly invasive tumor.The morphology of the pancreatic acinar cell carcinoma is similar to the PET,and the biological behaviors of two types tumor have significantly different,and distinguishing two types of famor has obvious clinical significance.
2013, 37(4): 424-426.
Abstract:
Objective:To investigate the clinical application value of serum thymidine kinase 1(TK1) test in the diagnosis and treatment of esophageal cancer.Methods:The TK1 level of 158 cases with esophageal cancer before operation(esophageal cancer group),40 cases with benign esophageal disease(benign disease group) and 50 healthy people(control group) were measured by enhanced chemiluminescence.In the esophageal cancer group,28 patients were randomly selected for following-up,their TK1 level were measured at 7 days and 1 month after operation.Results:The TK1 level before the operation and its positive rate in the esophageal cancer group were higher than those in the benign disease group and control group(P0.01),but the difference between the benign disease group and control group was not statistically significant(P0.05).Compared with preoperation,the TK1 levels of the 28 patients followed-up did not obviously decreased at 7 days(P0.05),but it decresed obviously in 1 month after operation in the esophageal cancer group(P0.01).Conclusions:The TK 1 test has certain clinical application value in the diagnosis,prognosis and curative effects of esophageal cancer.
Objective:To investigate the clinical application value of serum thymidine kinase 1(TK1) test in the diagnosis and treatment of esophageal cancer.Methods:The TK1 level of 158 cases with esophageal cancer before operation(esophageal cancer group),40 cases with benign esophageal disease(benign disease group) and 50 healthy people(control group) were measured by enhanced chemiluminescence.In the esophageal cancer group,28 patients were randomly selected for following-up,their TK1 level were measured at 7 days and 1 month after operation.Results:The TK1 level before the operation and its positive rate in the esophageal cancer group were higher than those in the benign disease group and control group(P0.01),but the difference between the benign disease group and control group was not statistically significant(P0.05).Compared with preoperation,the TK1 levels of the 28 patients followed-up did not obviously decreased at 7 days(P0.05),but it decresed obviously in 1 month after operation in the esophageal cancer group(P0.01).Conclusions:The TK 1 test has certain clinical application value in the diagnosis,prognosis and curative effects of esophageal cancer.
2013, 37(4): 427-429.
Abstract:
Objective:To evaluate the therapeutic effects of low pressure perfusion ureteroscope in the treatment of middle or distal ureteral small calculus(diameter 0.6 cm).Methods:Seventy-one cases with middle or distal ureteral small calculus were treated with low pressure perfusion under a Wolf F8/9.8 semirigid ureteroscope,18 cases needed to use pneumatic ballistic lithotripsy during operation.Results:All operations were sucessful without any serious complications.Mucosal laceration occurred in 25 cases with moderate or serious ureteral stricture.Two cases with submucosal false passage were cured by detaining double J catheter.No mucosal avulsion and perforation of the serious complications was found.Conclusions:The effect of low pressure perfusion ureteroscope in the treatment of middle or distal ureteral small calculus is good,which can avoid the migrating of small calculus into the renal pelvis.
Objective:To evaluate the therapeutic effects of low pressure perfusion ureteroscope in the treatment of middle or distal ureteral small calculus(diameter 0.6 cm).Methods:Seventy-one cases with middle or distal ureteral small calculus were treated with low pressure perfusion under a Wolf F8/9.8 semirigid ureteroscope,18 cases needed to use pneumatic ballistic lithotripsy during operation.Results:All operations were sucessful without any serious complications.Mucosal laceration occurred in 25 cases with moderate or serious ureteral stricture.Two cases with submucosal false passage were cured by detaining double J catheter.No mucosal avulsion and perforation of the serious complications was found.Conclusions:The effect of low pressure perfusion ureteroscope in the treatment of middle or distal ureteral small calculus is good,which can avoid the migrating of small calculus into the renal pelvis.
2013, 37(4): 429-430.
Abstract:
Objective:To investigate the cause and treatment of bile duct injury and residual gallbladder after difficult cholecystectomy.Methods:The clinical data of 564 cases with bile duct injury and residual gallbladder after difficult cholecystectomy were retrospectively analysed.Results:The cases after difficult cholecystectomy included 15 bile duct injury cases(2.66%).Thirteen cases were cured,1 case was improved,1 case died.The cases after difficult cholecystectomy included 12 residual gallbladder cases(2.13%).Four cases were cured,2 caes with gallstone recurrence refused surgery,6 cases without gallstone were improved.Conclusions:The occurrence of bile duct injury and residual gallbladder after difficult cholecystectomy are higher than average.The skillful operation and appropriate time can avoid severely operative complications.
Objective:To investigate the cause and treatment of bile duct injury and residual gallbladder after difficult cholecystectomy.Methods:The clinical data of 564 cases with bile duct injury and residual gallbladder after difficult cholecystectomy were retrospectively analysed.Results:The cases after difficult cholecystectomy included 15 bile duct injury cases(2.66%).Thirteen cases were cured,1 case was improved,1 case died.The cases after difficult cholecystectomy included 12 residual gallbladder cases(2.13%).Four cases were cured,2 caes with gallstone recurrence refused surgery,6 cases without gallstone were improved.Conclusions:The occurrence of bile duct injury and residual gallbladder after difficult cholecystectomy are higher than average.The skillful operation and appropriate time can avoid severely operative complications.
2013, 37(4): 431-433.
Abstract:
Objective:To explore the strategy and efficacy of microsurgerical treatment of hypertensive intracerebral hemorrhage of the basal ganglia region with small bone window.Methods:The clinical data of 15 patients with hypertensive intracerebral hemorrhage of the basal ganglia region were treated with the microsurgery of small bone window through transsylvian transinsular and superior temporal lobe gyrus were retrospectively analyzed.Eight cases and 7 cases were operated through transsylvian transinsular and the cortex of superior temporal lobe gyrus,respectively.Results:No deaths occurred.According to the actirvties of daily living test,grade Ⅰ,Ⅱ,Ⅲ,Ⅳand Ⅴwere found in 3,7,3,1 and 1 patients,respectively.Conclusions:According to the amount and site of hematoma,microsurgical treatment of hypertensive intracerebral hemorrhage in basal ganglia region with small bone window via transsylvian transinsular and superior temporal lobe gyrus is an effective approach,which is consistent with the concept minimal invasion.
Objective:To explore the strategy and efficacy of microsurgerical treatment of hypertensive intracerebral hemorrhage of the basal ganglia region with small bone window.Methods:The clinical data of 15 patients with hypertensive intracerebral hemorrhage of the basal ganglia region were treated with the microsurgery of small bone window through transsylvian transinsular and superior temporal lobe gyrus were retrospectively analyzed.Eight cases and 7 cases were operated through transsylvian transinsular and the cortex of superior temporal lobe gyrus,respectively.Results:No deaths occurred.According to the actirvties of daily living test,grade Ⅰ,Ⅱ,Ⅲ,Ⅳand Ⅴwere found in 3,7,3,1 and 1 patients,respectively.Conclusions:According to the amount and site of hematoma,microsurgical treatment of hypertensive intracerebral hemorrhage in basal ganglia region with small bone window via transsylvian transinsular and superior temporal lobe gyrus is an effective approach,which is consistent with the concept minimal invasion.
2013, 37(4): 434-436.
Abstract:
Objective:To observe the clinical curative effects of sitagliptin in the treatment of obesity type 2 diabetes.Methods:Forty cases with type 2 diabetes without fine control of blood glucose level were treated with sitagliptin for 12 weeks,which was based on original clinical protocols.The levels of fasting blood glucose(FBG),2 hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),c-peptide and 2 h c-peptide,and the blood routine,blood pressure and the liver and kidney functions were detected before treatment and at 12 weeks after treatment.Results:Compared with before treatment,the levels of FBG,2hPG,HbA1c,BMI and insulin dose decreased significantly(P0.05 to P0.01).The levels of c-peptide and 2 h c-peptide improved(P0.01) at 12 weeks after treatment with sitagliptin.There were no significant changes in the levels of blood pressure,and the liver and kidney functions,red blood cells and platelets after treatment(P0.05).The white blood cells after treatment were lower than those before treatment(P0.01).Conclusions:Sitagliptin is a safe and effective hypoglycemic drug in the treatment of obesity type 2 diabetes and without obvious adverse effects.
Objective:To observe the clinical curative effects of sitagliptin in the treatment of obesity type 2 diabetes.Methods:Forty cases with type 2 diabetes without fine control of blood glucose level were treated with sitagliptin for 12 weeks,which was based on original clinical protocols.The levels of fasting blood glucose(FBG),2 hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),c-peptide and 2 h c-peptide,and the blood routine,blood pressure and the liver and kidney functions were detected before treatment and at 12 weeks after treatment.Results:Compared with before treatment,the levels of FBG,2hPG,HbA1c,BMI and insulin dose decreased significantly(P0.05 to P0.01).The levels of c-peptide and 2 h c-peptide improved(P0.01) at 12 weeks after treatment with sitagliptin.There were no significant changes in the levels of blood pressure,and the liver and kidney functions,red blood cells and platelets after treatment(P0.05).The white blood cells after treatment were lower than those before treatment(P0.01).Conclusions:Sitagliptin is a safe and effective hypoglycemic drug in the treatment of obesity type 2 diabetes and without obvious adverse effects.
2013, 37(4): 451-454.
Abstract:
Objective:To explore the association of interaction anxiousness and interpersonal attribution style with explicit self-esteem,discuss the mediating effect of explicit self-esteem on the interpersonal attribution style and the interaction anxiousness in middle school students.Methods:Based on stratified,random cluster sampling method,2 626 students from four middle schools in Bengbu were studied.The students were surveyed by Interpersonal Attribution Scale,Interaction Anxiousness Scale and Self-Esteem Scale.Results:The score of the interpersonal attribution style in male students was significantly higher than that in the female(P0.01);the score of explicit self-esteem in junior high school students was significantly higher than that in senior high school ones(P0.01).The total interpersonal attribution style and each dimension had positive correlation with the interaction anxiousness(P0.01);the explicit self-esteem had negative correlation with the interaction anxiousness(P 0.01).Explicit self-esteem had partial mediating effect on the interaction anxiousness in the interpersonal attribution style,and the mediating effect accounted for 34.62%.The proportion of the mediating effect reached 52.61% in the total effects.Conclusions:Guiding the students to positive interpersonal attribution style and appropriate degree of self-esteem can relieve and decrease the anxiety level in middle school students.
Objective:To explore the association of interaction anxiousness and interpersonal attribution style with explicit self-esteem,discuss the mediating effect of explicit self-esteem on the interpersonal attribution style and the interaction anxiousness in middle school students.Methods:Based on stratified,random cluster sampling method,2 626 students from four middle schools in Bengbu were studied.The students were surveyed by Interpersonal Attribution Scale,Interaction Anxiousness Scale and Self-Esteem Scale.Results:The score of the interpersonal attribution style in male students was significantly higher than that in the female(P0.01);the score of explicit self-esteem in junior high school students was significantly higher than that in senior high school ones(P0.01).The total interpersonal attribution style and each dimension had positive correlation with the interaction anxiousness(P0.01);the explicit self-esteem had negative correlation with the interaction anxiousness(P 0.01).Explicit self-esteem had partial mediating effect on the interaction anxiousness in the interpersonal attribution style,and the mediating effect accounted for 34.62%.The proportion of the mediating effect reached 52.61% in the total effects.Conclusions:Guiding the students to positive interpersonal attribution style and appropriate degree of self-esteem can relieve and decrease the anxiety level in middle school students.
2013, 37(4): 455-458.
Abstract:
Objective:To explore the risk factors of undergraduate depression and provide the basis for developing psychological warning mechanism and education.Methods:Two thousand five hundred and ninety-three undergraduates from six universities were randomly selected and required to fill out an uniform general questionnaire(including some basic information such as age,grade,family harmony degree,profession satisfaction,etc.) and the standardized Self-rating Depression Scale.The risk factors were analysed by binary logistic regression procedure.Results:The depression symptoms of 27.70% undergraduates were evident,which included 19.21% mild,7.52% moderate and 1.00% severe depressive symptoms.The mean depression severity was 0.480.10.There were a certain relation between gender,family financial situation,family harmony degree,affectional status,profession satisfaction,physical exercise,social activity and interpersonal relationship and depressive symptoms(P0.05 to P0.01).The grade,only-child,single-parent family and stay-at-home children were not significantly associated with depression(P0.05).Conclusions:A variety of factors are involved in the occurrence of undergraduate depression.Paying attention to the risk factors,establishing effective psychological screening and early warning mechanisms and timely tracking and intervention is the foundation of preventing the mental health deteriorating of undergraduate.
Objective:To explore the risk factors of undergraduate depression and provide the basis for developing psychological warning mechanism and education.Methods:Two thousand five hundred and ninety-three undergraduates from six universities were randomly selected and required to fill out an uniform general questionnaire(including some basic information such as age,grade,family harmony degree,profession satisfaction,etc.) and the standardized Self-rating Depression Scale.The risk factors were analysed by binary logistic regression procedure.Results:The depression symptoms of 27.70% undergraduates were evident,which included 19.21% mild,7.52% moderate and 1.00% severe depressive symptoms.The mean depression severity was 0.480.10.There were a certain relation between gender,family financial situation,family harmony degree,affectional status,profession satisfaction,physical exercise,social activity and interpersonal relationship and depressive symptoms(P0.05 to P0.01).The grade,only-child,single-parent family and stay-at-home children were not significantly associated with depression(P0.05).Conclusions:A variety of factors are involved in the occurrence of undergraduate depression.Paying attention to the risk factors,establishing effective psychological screening and early warning mechanisms and timely tracking and intervention is the foundation of preventing the mental health deteriorating of undergraduate.
2013, 37(4): 459-460.
Abstract:
Objective:To explore magnetic resonance imaging(MRI) appearance of spinal cord multiple sclerosis and its diagnostic value.Methods:The location,extent,morphology,MRI signal and enhancement degree of spinal cord multiple sclerosis were analyzed in 9 cases.Results:Cervical,cervical and thoracic,and thoracic spinal cord were involved in 4,3 and 2 cases,respectively.The lesions were patches and long ribbon in shape.Low or iso-signal intensity on T1WI and high-signal intensity on T1WI were found.Point flake high lesions signal on T2WI were observed,The lesion was enhancement or no enhancement by enhanced MRI scan.Conclusions:MRI can help the differential diagnosis with other intraspinal diseases.
Objective:To explore magnetic resonance imaging(MRI) appearance of spinal cord multiple sclerosis and its diagnostic value.Methods:The location,extent,morphology,MRI signal and enhancement degree of spinal cord multiple sclerosis were analyzed in 9 cases.Results:Cervical,cervical and thoracic,and thoracic spinal cord were involved in 4,3 and 2 cases,respectively.The lesions were patches and long ribbon in shape.Low or iso-signal intensity on T1WI and high-signal intensity on T1WI were found.Point flake high lesions signal on T2WI were observed,The lesion was enhancement or no enhancement by enhanced MRI scan.Conclusions:MRI can help the differential diagnosis with other intraspinal diseases.
2013, 37(4): 461-464.
Abstract:
Objective:To investigate the value of MRI with rectal irrigation in diagnosis and preoperative staging of rectal cancer.Methods:Thirty-two patients with suspected rectal cancer were detected by MRI with rectal irrigation.All patients were scaned under T1WI and T2WI of axial and sagittal plane.Ten cases were detected through MRI with rectal irrigation.The tumor characteristics,surrounding infiltrating and lymph node enlargement were measured,which were compared with pathology.Results:The overall diagnosis accuracy of T staging by MRI with rectal irrigation was 87.5% and the diagnosis accuracy of less than or equal to T2,T3 and T4 were 78.6%,93.3% and 100.0%,respectively.The sensitivity and specificity of lymph nodes invasion were 56.5% and 98.4%.The shape,size and position of rectal neoplasms and stricture of rectal lumen could be clearly displayed under MRI.Conclusions:MRI with rectal irrigation can accurately judge the preoperative stage of rectal neoplasms,which can help to make reasonable treatment and prognosis assessment.It is a supplement for routine scan.
Objective:To investigate the value of MRI with rectal irrigation in diagnosis and preoperative staging of rectal cancer.Methods:Thirty-two patients with suspected rectal cancer were detected by MRI with rectal irrigation.All patients were scaned under T1WI and T2WI of axial and sagittal plane.Ten cases were detected through MRI with rectal irrigation.The tumor characteristics,surrounding infiltrating and lymph node enlargement were measured,which were compared with pathology.Results:The overall diagnosis accuracy of T staging by MRI with rectal irrigation was 87.5% and the diagnosis accuracy of less than or equal to T2,T3 and T4 were 78.6%,93.3% and 100.0%,respectively.The sensitivity and specificity of lymph nodes invasion were 56.5% and 98.4%.The shape,size and position of rectal neoplasms and stricture of rectal lumen could be clearly displayed under MRI.Conclusions:MRI with rectal irrigation can accurately judge the preoperative stage of rectal neoplasms,which can help to make reasonable treatment and prognosis assessment.It is a supplement for routine scan.
2013, 37(4): 466-468,478.
Abstract:
Objective:To analyze the reasons for unreliable outcome resulting from the plasmas with high D-dimer(D-D) concentration diluted to 8 times,and explore the optimal dilution of the plasmas for D-D test.Methods:The D-D standard curve was derived from the six concentration levels of D-D standard plasma by a customary way.The standards and the patient plasma were diluted to 2 times,4 times and 8 times in a coagulation analyzer or by manual,and then they were analyzed in a calibrated analyzer;The results in the analyzer and by manual were statistically compared.Results:The standard curve of D-D was similar to the letter S.The D-D concentration when the plasma was diluted to 8 times in the analyzer was decreased significantly(P0.01),compared with that when diluted to 2 times by manual.However,there was not statistical difference between the plasma and its dilution to 2 times or between the same dilutions in both modes(P0.05).Conclusions:The higher the dilution is,the more obvious the difference will be.Therefore,the plasma with high D-D concentration should be diluted as less times as it can be determined in order to assure the reliability of D-D value.
Objective:To analyze the reasons for unreliable outcome resulting from the plasmas with high D-dimer(D-D) concentration diluted to 8 times,and explore the optimal dilution of the plasmas for D-D test.Methods:The D-D standard curve was derived from the six concentration levels of D-D standard plasma by a customary way.The standards and the patient plasma were diluted to 2 times,4 times and 8 times in a coagulation analyzer or by manual,and then they were analyzed in a calibrated analyzer;The results in the analyzer and by manual were statistically compared.Results:The standard curve of D-D was similar to the letter S.The D-D concentration when the plasma was diluted to 8 times in the analyzer was decreased significantly(P0.01),compared with that when diluted to 2 times by manual.However,there was not statistical difference between the plasma and its dilution to 2 times or between the same dilutions in both modes(P0.05).Conclusions:The higher the dilution is,the more obvious the difference will be.Therefore,the plasma with high D-D concentration should be diluted as less times as it can be determined in order to assure the reliability of D-D value.
2013, 37(4): 469-470.
Abstract:
Objective:To study the drug resistance of Mycobacterium tuberculosis(TB) in Bengbu for providing the basis of the diagnosis and treatment of patients with drug-resistant TB.Methods:Four hundred twenty-five high risk patients were screened by Ziehl-Neelsen anti-acid staining.The mycobacterium tuberculosis of sputum in the positive patients were cultured with acid modified Roche solid culture medium,and the drug sensitive test of the cultured positive patients were measured by the indirect method of absolute concentration.Results:Patients with positive sputum culture were 267 cases.Patients with drug-resistant TB were 184 cases,including 45 cases of single-drug resistance,76 cases of multidrug resistance,41 cases of multiple drug resistance and 22 cases of extensively drug resistance.Conclusions:The drug resistance of patients with TB is serious in Bengbu.The specialist out-patient treatment,making reasonable and effective treatment and strengthening the supervision management is a key to prevent the drug resistance of patient with TB.
Objective:To study the drug resistance of Mycobacterium tuberculosis(TB) in Bengbu for providing the basis of the diagnosis and treatment of patients with drug-resistant TB.Methods:Four hundred twenty-five high risk patients were screened by Ziehl-Neelsen anti-acid staining.The mycobacterium tuberculosis of sputum in the positive patients were cultured with acid modified Roche solid culture medium,and the drug sensitive test of the cultured positive patients were measured by the indirect method of absolute concentration.Results:Patients with positive sputum culture were 267 cases.Patients with drug-resistant TB were 184 cases,including 45 cases of single-drug resistance,76 cases of multidrug resistance,41 cases of multiple drug resistance and 22 cases of extensively drug resistance.Conclusions:The drug resistance of patients with TB is serious in Bengbu.The specialist out-patient treatment,making reasonable and effective treatment and strengthening the supervision management is a key to prevent the drug resistance of patient with TB.
2013, 37(4): 471-473.
Abstract:
Objective:To evaluate the automatic dry chemistry method in detecting serum C reactive protein(CRP).Methods:The serum CRP was detected by the VITROS-250 dry chemistry analyzer and the HITACH-7600 automatic chemistry analyzer simultaneously.Results:The linear range of the dry chemistry method was 7.0-110.0 mg/L;the high,mean and low value within and between-run CV were 1.79%,1.90%,2.46% and 1.95%,2.53%,3.62% respectively.The average recovery rate was 98.2%;the correlation coefficient and correlation equation to the HITACH-7600 automatic chemistry analyzer were R2=0.989 5,Y=0.970 2X+0.431 9.There was no significant interference in the assay when hemolysin2.0 g/L,bilirubin356 mol/L and triglyceride7.8 mmol/L.Conclusions:Automatic dry chemistry is a fast,accurate and stable method for the detection of CRP.
Objective:To evaluate the automatic dry chemistry method in detecting serum C reactive protein(CRP).Methods:The serum CRP was detected by the VITROS-250 dry chemistry analyzer and the HITACH-7600 automatic chemistry analyzer simultaneously.Results:The linear range of the dry chemistry method was 7.0-110.0 mg/L;the high,mean and low value within and between-run CV were 1.79%,1.90%,2.46% and 1.95%,2.53%,3.62% respectively.The average recovery rate was 98.2%;the correlation coefficient and correlation equation to the HITACH-7600 automatic chemistry analyzer were R2=0.989 5,Y=0.970 2X+0.431 9.There was no significant interference in the assay when hemolysin2.0 g/L,bilirubin356 mol/L and triglyceride7.8 mmol/L.Conclusions:Automatic dry chemistry is a fast,accurate and stable method for the detection of CRP.
2013, 37(4): 473-475.
Abstract:
Objective:To investigate the related factors of diabetes medication compliance in Dongguan city and provide the basis to improve the medication compliance.Methods:Eight hundred and forty diabetic patients were investigated with questionnaire by random sampling and on-site investigation,results were analyzed statistically.Results:For 840 research objects,the differences of diabetes medication compliance rates in different sex,age and degree of education were not statistical significance(P0.05),the differences of diabetes medication compliance rates in different diabetes course of disease and occupations were statistical significance(P0.05).Conclusions:The course of disease and occupations of diabetic patients have impact on their diabetes cognition,which influences medication compliance.
Objective:To investigate the related factors of diabetes medication compliance in Dongguan city and provide the basis to improve the medication compliance.Methods:Eight hundred and forty diabetic patients were investigated with questionnaire by random sampling and on-site investigation,results were analyzed statistically.Results:For 840 research objects,the differences of diabetes medication compliance rates in different sex,age and degree of education were not statistical significance(P0.05),the differences of diabetes medication compliance rates in different diabetes course of disease and occupations were statistical significance(P0.05).Conclusions:The course of disease and occupations of diabetic patients have impact on their diabetes cognition,which influences medication compliance.
2013, 37(4): 476-478.
Abstract:
Objective:To establish the grey system model GM(1,1) for predicting the incidence trend of hepatitis B in Changzhou city.Methods:Grey Model(1,1) was established according to the data of the incidence of hepatitis B from China information system for disease control and prevention during 2004 to 2011 in Changzhou city,which was used to predict the incidence of hepatitis B in 2012,2013,2014.Results:The x(1)(k+1)=-228.213 9 e-0.237 73k+304.554 0,of prediction model GM(1,1) was established.The fitting accuracy of the model was excellent[Check differential ratio(C)=0.069,probabe error(P)=1].The incidence rates of hepatitis B in Changzhou city from 2012 to 2014 were 9.143 5,7.208 9 and 5.6836 per hundred thousand using the model predicting,respectively.Conclusions:The grey system model GM(1,1) can fairly predict the incidence trend of hepatitis B in Changzhou city,and the predicting results have reference value.
Objective:To establish the grey system model GM(1,1) for predicting the incidence trend of hepatitis B in Changzhou city.Methods:Grey Model(1,1) was established according to the data of the incidence of hepatitis B from China information system for disease control and prevention during 2004 to 2011 in Changzhou city,which was used to predict the incidence of hepatitis B in 2012,2013,2014.Results:The x(1)(k+1)=-228.213 9 e-0.237 73k+304.554 0,of prediction model GM(1,1) was established.The fitting accuracy of the model was excellent[Check differential ratio(C)=0.069,probabe error(P)=1].The incidence rates of hepatitis B in Changzhou city from 2012 to 2014 were 9.143 5,7.208 9 and 5.6836 per hundred thousand using the model predicting,respectively.Conclusions:The grey system model GM(1,1) can fairly predict the incidence trend of hepatitis B in Changzhou city,and the predicting results have reference value.
2013, 37(4): 479-481.
Abstract:
Objective:To evaluate the application value of case-based teaching method in medical imaging.Methods:Case-based teaching method was implemented in medical imaging curriculum among clinical students.The teaching effects were evaluated by stage test and questionnaire.Medical students were randomly divided into observation and control group.The observation and control group were taught by case-based teaching and traditional multimedia teaching,respectively.Results:The learning interest and ability of problem solving,thinking,memory and summary and combining clinic of observation group were motivated and improved,which was better than those in control group(P0.01 to P0.05).The scores of theory test,reading film and questionnaire of observation group were significantly better than those in control group(P0.05).Conclusions:Case-based teaching method has an obvious advantage over traditional multimedia teaching in medical imaging curriculum,but the case selection and teaching effect evaluation are need to further improve and perfect.
Objective:To evaluate the application value of case-based teaching method in medical imaging.Methods:Case-based teaching method was implemented in medical imaging curriculum among clinical students.The teaching effects were evaluated by stage test and questionnaire.Medical students were randomly divided into observation and control group.The observation and control group were taught by case-based teaching and traditional multimedia teaching,respectively.Results:The learning interest and ability of problem solving,thinking,memory and summary and combining clinic of observation group were motivated and improved,which was better than those in control group(P0.01 to P0.05).The scores of theory test,reading film and questionnaire of observation group were significantly better than those in control group(P0.05).Conclusions:Case-based teaching method has an obvious advantage over traditional multimedia teaching in medical imaging curriculum,but the case selection and teaching effect evaluation are need to further improve and perfect.
2013, 37(4): 489-491.
Abstract:
Objective:To observe the effects of dry-wet cotton wipe on prevention the oral ulcer in patient with orotracheal intubation.Methods:Eighty-six patients with orotracheal intubation were randomly divided into observation group and control group.The mouths of observation group were nursed by dry-wet cotton wipe,the control group were nursed by oral irrigation.The incidence of ulcer,oral cleanliness and fungal infection rate of two groups were compared.Results:The observation group with oral cleanliness lower than 6 points dropped from 40 cases to 6 cases,the control group dropped from 41 cases to 28 cases,the difference of which was statistic significance(P0.01).The incidence of ulcer and fungal infection rate in the observation and control group were 11.6% and 20.9%,23.3% and 34.9%,respectively,the differences of those were not statistic significance(P0.05).Conclusions:The dry-wet cotton wipe in the prevention of the oral ulcer in patients with orotracheal intubation has good effects in oral hygiene and clinical treatment,which is easy operation and worth of applying widely in clinic.
Objective:To observe the effects of dry-wet cotton wipe on prevention the oral ulcer in patient with orotracheal intubation.Methods:Eighty-six patients with orotracheal intubation were randomly divided into observation group and control group.The mouths of observation group were nursed by dry-wet cotton wipe,the control group were nursed by oral irrigation.The incidence of ulcer,oral cleanliness and fungal infection rate of two groups were compared.Results:The observation group with oral cleanliness lower than 6 points dropped from 40 cases to 6 cases,the control group dropped from 41 cases to 28 cases,the difference of which was statistic significance(P0.01).The incidence of ulcer and fungal infection rate in the observation and control group were 11.6% and 20.9%,23.3% and 34.9%,respectively,the differences of those were not statistic significance(P0.05).Conclusions:The dry-wet cotton wipe in the prevention of the oral ulcer in patients with orotracheal intubation has good effects in oral hygiene and clinical treatment,which is easy operation and worth of applying widely in clinic.
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