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2013 Vol. 38, No. 5
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2013, 37(5): 513-515.
Abstract:
Objective: To observe the humoral immune response induced by Taenia solium oncosphere TSO45-4B antigens FnⅢ structure domain linear B cells epitope peptides in mice.Methods: The two predicted B cell epitope peptides of TSO45-4B Fn Ⅲ structure domain conjugated with carrier protein of keyhole limpet hemocyanin were synthesized and used to immunize mice.The mice specific serum antibody titer to the epitope peptides synthesized was tested by ELISA.Results: The specific antibody to one of the predicted epitope peptides synthesized was found in mice serum,and the titer was 1∶ 1 280.Conclusions: One of the two predicted linear B cell epitope peptides of TSO45-4B FnⅢ structure domain can induce the humoral immune response in mice.
Objective: To observe the humoral immune response induced by Taenia solium oncosphere TSO45-4B antigens FnⅢ structure domain linear B cells epitope peptides in mice.Methods: The two predicted B cell epitope peptides of TSO45-4B Fn Ⅲ structure domain conjugated with carrier protein of keyhole limpet hemocyanin were synthesized and used to immunize mice.The mice specific serum antibody titer to the epitope peptides synthesized was tested by ELISA.Results: The specific antibody to one of the predicted epitope peptides synthesized was found in mice serum,and the titer was 1∶ 1 280.Conclusions: One of the two predicted linear B cell epitope peptides of TSO45-4B FnⅢ structure domain can induce the humoral immune response in mice.
2013, 37(5): 516-518.
Abstract:
Objective: To explore the application value of the 99mTc-CXC chemokine receptor 4(CXCR4) inhibitor derived from virus macrophage inflammatory protein(NT21MP) as SPECT imaging agent in mouse breast cancer.Methods: NT21MP was directly radiolabeled using pretinning method.The radiochemical purity and stability of 99mTc-NT21MP in plasma was measured by chromatographic system.The mouse model of breast cancer was established.SPECT imaging of model mice were detected by intravenous injection 99mTc-NT21MP.T / NT value was calculated,and the expressions of CXCR4 and SDF-1 in tumor and lung tissue were detected by immunohistochemistry method.Results: The radiochemical purity of 99mTc-NT21MP was 95%.It was stable in blood plasma within 2 hours,its radiochemical purity was more than 90%.99mTc-NT21MP could target to tumor tissues after injecting.T / NT reached 4.6 in 2 hours,the expression of CXCR4 and SDF-1 were high in tumour and lung tissue,respectively.Conclusions:99mTc-NT21MP is easily prepared,and high targeting,which has high application value in early diagnosis of CXCR4 positive tumor.
Objective: To explore the application value of the 99mTc-CXC chemokine receptor 4(CXCR4) inhibitor derived from virus macrophage inflammatory protein(NT21MP) as SPECT imaging agent in mouse breast cancer.Methods: NT21MP was directly radiolabeled using pretinning method.The radiochemical purity and stability of 99mTc-NT21MP in plasma was measured by chromatographic system.The mouse model of breast cancer was established.SPECT imaging of model mice were detected by intravenous injection 99mTc-NT21MP.T / NT value was calculated,and the expressions of CXCR4 and SDF-1 in tumor and lung tissue were detected by immunohistochemistry method.Results: The radiochemical purity of 99mTc-NT21MP was 95%.It was stable in blood plasma within 2 hours,its radiochemical purity was more than 90%.99mTc-NT21MP could target to tumor tissues after injecting.T / NT reached 4.6 in 2 hours,the expression of CXCR4 and SDF-1 were high in tumour and lung tissue,respectively.Conclusions:99mTc-NT21MP is easily prepared,and high targeting,which has high application value in early diagnosis of CXCR4 positive tumor.
2013, 37(5): 516-523.
Abstract:
Objective: To establish a mice systemic lupus erythematosus(SLE) model induced by Pristane.Methods: Female BALB/ c mice were divided into two groups randomly.The mice in model group were received a single intraperitoneal injection of 0.5 ml Pristane,while the mice in control group were received 0.9% sodium chloride injection with same volume.Before and after injection,anti-Sm / RNP antibody and anti-dsDNA antibody in serum were detected by ELISA,proteinuria content was quantified by Albustix dipstick test,and the changes of signs and symptoms in these mice were monitored monthly.Six months after injection,all mice were killed and lesions in abdominal organs were checked by anatomy.All injured organs were observed and kidneys were inspected by pathology.Histopathologic changes of injured organs were determined by HE staining method,and glomerular IgG deposition in kidney was detected by direct immunofluorescence staining method.Results: Serum anti-Sm / RNP antibody and anti-dsDNA antibody were detected two months after Pristane injection,and increased monthly.Compared with the control mice in the corresponding period,serum anti-Sm / RNP antibody and anti-dsDNA antibody in the model mice were increased obviously at 3-6 months after injection(P 0.01) and at 4-6 months after injection respectively(P 0.01).The increase of serum anti-Sm / RNP antibody was significantly higher than that of serum anti-dsDNA antibody.Urine protein( +) was detected since 3 months after Pristane injection,and at 6 months,urine protein content was significantly higher than that in the control mice(P 0.01).The symptom of arthritis in legs was shown at the third months after Pristane injection,and the positive incidence was 55% after 6 months,apparently higher than that in the control mice(P = 0.004).After the mice were killed at the sixth months,abdominal lipogranulomas more or less were found in most of the model mice.Kidney pathological examination was shown in over 50% Pristane-treated mice,glomerulonephritis more or less were observed and obvious immune complex deposition was observed in the wall of capillaries.Whereas,with an exception of one mouse developing proteinuria at 6th month after injection,none of the control mice displayed any pathological changes.Conclusions: Pristane can successfully induce mice SLE in BALB / c by intraperitoneal injection and is steady and reliable.
Objective: To establish a mice systemic lupus erythematosus(SLE) model induced by Pristane.Methods: Female BALB/ c mice were divided into two groups randomly.The mice in model group were received a single intraperitoneal injection of 0.5 ml Pristane,while the mice in control group were received 0.9% sodium chloride injection with same volume.Before and after injection,anti-Sm / RNP antibody and anti-dsDNA antibody in serum were detected by ELISA,proteinuria content was quantified by Albustix dipstick test,and the changes of signs and symptoms in these mice were monitored monthly.Six months after injection,all mice were killed and lesions in abdominal organs were checked by anatomy.All injured organs were observed and kidneys were inspected by pathology.Histopathologic changes of injured organs were determined by HE staining method,and glomerular IgG deposition in kidney was detected by direct immunofluorescence staining method.Results: Serum anti-Sm / RNP antibody and anti-dsDNA antibody were detected two months after Pristane injection,and increased monthly.Compared with the control mice in the corresponding period,serum anti-Sm / RNP antibody and anti-dsDNA antibody in the model mice were increased obviously at 3-6 months after injection(P 0.01) and at 4-6 months after injection respectively(P 0.01).The increase of serum anti-Sm / RNP antibody was significantly higher than that of serum anti-dsDNA antibody.Urine protein( +) was detected since 3 months after Pristane injection,and at 6 months,urine protein content was significantly higher than that in the control mice(P 0.01).The symptom of arthritis in legs was shown at the third months after Pristane injection,and the positive incidence was 55% after 6 months,apparently higher than that in the control mice(P = 0.004).After the mice were killed at the sixth months,abdominal lipogranulomas more or less were found in most of the model mice.Kidney pathological examination was shown in over 50% Pristane-treated mice,glomerulonephritis more or less were observed and obvious immune complex deposition was observed in the wall of capillaries.Whereas,with an exception of one mouse developing proteinuria at 6th month after injection,none of the control mice displayed any pathological changes.Conclusions: Pristane can successfully induce mice SLE in BALB / c by intraperitoneal injection and is steady and reliable.
2013, 37(5): 524-527.
Abstract:
Objective: To establish the sepsis rat model and explore the structure and function change of kidney and the expression of nuclear factor B(NF-B) in kidney.Methods: Thirty-six male Sprague-Dawley rats were randomly divided into sham operation group(Sham group) and cecal ligation and puncture group(CLP group)(18 rats each group).The sepsis rat model were established by cecal ligation and puncture in CLP group,and the Sham group didn't do cecal ligation and puncture processing.The heart rate(HR),mean arterial perssure(MAP),the levels of creatine(Cr) and blood urea nitrogen(BUN) and kidney structure change of two groups were observed at 6,12 and 24 hours after operation.The expression of NF-B in kidney was observed by immunohistochemical staining.Results: Compared with time-matched Sham group,the HR and MAP of CLP group increased at 6 to 12 hours after operation(P 0.01 and P 0.05),MAP of CLP group decreased at 24 hours(P 0.01).Compared with time-matched Sham group,the level of BUN of CLP group increased at 6 to 24 hours(P 0.05 to P 0.01),the level of Cr significantly increased at 24 hours(P 0.01) in CLP group.Histology showed the glomus gore and shrinkage of renal corpuscle and renal capsule cavity expanding.The number of glomus with gore and shrinkage together with renal tubule epithelial cell swelling and necrosis increased with the disease duration in CLP group.Immunohistochemistry revealed that NF-B located mainly in cytoplasm and its staining was light in Sham group,and NF-B located mainly in cell nucleus and its staining was deep in CLP group.Conclusions: With the course extension of sepsis,the injury of rat kidney structure and function aggravates.The high expressions of NF-B in cell nucleus suggest that the activation of NF-B may be an important factor to promote renal structure and functional damage.
Objective: To establish the sepsis rat model and explore the structure and function change of kidney and the expression of nuclear factor B(NF-B) in kidney.Methods: Thirty-six male Sprague-Dawley rats were randomly divided into sham operation group(Sham group) and cecal ligation and puncture group(CLP group)(18 rats each group).The sepsis rat model were established by cecal ligation and puncture in CLP group,and the Sham group didn't do cecal ligation and puncture processing.The heart rate(HR),mean arterial perssure(MAP),the levels of creatine(Cr) and blood urea nitrogen(BUN) and kidney structure change of two groups were observed at 6,12 and 24 hours after operation.The expression of NF-B in kidney was observed by immunohistochemical staining.Results: Compared with time-matched Sham group,the HR and MAP of CLP group increased at 6 to 12 hours after operation(P 0.01 and P 0.05),MAP of CLP group decreased at 24 hours(P 0.01).Compared with time-matched Sham group,the level of BUN of CLP group increased at 6 to 24 hours(P 0.05 to P 0.01),the level of Cr significantly increased at 24 hours(P 0.01) in CLP group.Histology showed the glomus gore and shrinkage of renal corpuscle and renal capsule cavity expanding.The number of glomus with gore and shrinkage together with renal tubule epithelial cell swelling and necrosis increased with the disease duration in CLP group.Immunohistochemistry revealed that NF-B located mainly in cytoplasm and its staining was light in Sham group,and NF-B located mainly in cell nucleus and its staining was deep in CLP group.Conclusions: With the course extension of sepsis,the injury of rat kidney structure and function aggravates.The high expressions of NF-B in cell nucleus suggest that the activation of NF-B may be an important factor to promote renal structure and functional damage.
2013, 37(5): 528-530.
Abstract:
Objective: To explore the clinical characteristics and incidence rate of postoperative complication of elderly patients with gastric carcinoma,and improve their perioperative management.Methods: The clinical data of 45 patients older than 70 years old(elderly group) and 60 patients less than 70 years old(control group) with gastric carcinoma were retrospectively analyzed.The incidence rates of perioperative and postoperative complications and treatment of two groups were investigated.Results: There were more clinical characteristics of other system diseases,but no specificly clinical manifestations in elderly group before operation.The incidence rate of other system disease in elderly group was higher than that in control group before operation(P 0.05 to P 0.01).The incidence rates of postoperative complications in elderly group and control group were 22.2% and 11.7%,respectively,the difference had no statistic significance(P 0.05).Conclusions: The elderly patients with gastric carcinoma have more other system diseases before operation and higher incidence rate of postoperative complications.Strenghening the perioperative management of elderly patients with gastric carcinoma can reduce the postoperative complications and improve their survival rate and living quality.
Objective: To explore the clinical characteristics and incidence rate of postoperative complication of elderly patients with gastric carcinoma,and improve their perioperative management.Methods: The clinical data of 45 patients older than 70 years old(elderly group) and 60 patients less than 70 years old(control group) with gastric carcinoma were retrospectively analyzed.The incidence rates of perioperative and postoperative complications and treatment of two groups were investigated.Results: There were more clinical characteristics of other system diseases,but no specificly clinical manifestations in elderly group before operation.The incidence rate of other system disease in elderly group was higher than that in control group before operation(P 0.05 to P 0.01).The incidence rates of postoperative complications in elderly group and control group were 22.2% and 11.7%,respectively,the difference had no statistic significance(P 0.05).Conclusions: The elderly patients with gastric carcinoma have more other system diseases before operation and higher incidence rate of postoperative complications.Strenghening the perioperative management of elderly patients with gastric carcinoma can reduce the postoperative complications and improve their survival rate and living quality.
2013, 37(5): 531-533.
Abstract:
Objective: To investigate the effects of perioperative psychological support therapy on cognitive function of elderly patient with femoral neck fracture.Methods: Thirty-four cases with femoral neck fracture treated with internal fixation under general anesthesia were randomly divided into perioperative psychological support therapy group(PPST group) and control group(17 cases each group).The blood pressure(BP),heart rate(HR),pulse oxygen saturation and electrocardiography of two groups were observed during the operation.The mean artery pressure(MAP) and HR of two groups were recorded during extubation and at 5 minutes after extubation.mini-mental state examination(MMSE) scores of two groups were recorded before anesthesia and at 3,6,24 and 72 hours after operation,which was used to evaluate their cognitive function.Results: The levels of MAP and HR of two groups during extubation and at 5 minutes after extubation were higher than those after operation(P 0.01),but the increasing degree of control group was significantly higher than that in PPST group(P 0.01).Compared with preanesthesia,MMSE scores decreased significantly at 3 hours after operation in PPST group(P 0.01) and the control group decreased significantly at 3,6 and 24 hours after operation(P 0.01),the differeces of MMSE scores in two groups were not statistical significance at 72 hours after operation(P 0.05).MMSE scores of control group were lower than that in PPST group at 3,6 and 24 hours after operation(P 0.05 to P 0.01).Conclusions: Perioperative psychological support therapy can significantly reduce the incidence of postoperative cognitive dysfunction of elderly patient with femoral neck fracture and improve the relative stability of patients' circulation before and after the extubation,which keep patient stable during perioperative period.
Objective: To investigate the effects of perioperative psychological support therapy on cognitive function of elderly patient with femoral neck fracture.Methods: Thirty-four cases with femoral neck fracture treated with internal fixation under general anesthesia were randomly divided into perioperative psychological support therapy group(PPST group) and control group(17 cases each group).The blood pressure(BP),heart rate(HR),pulse oxygen saturation and electrocardiography of two groups were observed during the operation.The mean artery pressure(MAP) and HR of two groups were recorded during extubation and at 5 minutes after extubation.mini-mental state examination(MMSE) scores of two groups were recorded before anesthesia and at 3,6,24 and 72 hours after operation,which was used to evaluate their cognitive function.Results: The levels of MAP and HR of two groups during extubation and at 5 minutes after extubation were higher than those after operation(P 0.01),but the increasing degree of control group was significantly higher than that in PPST group(P 0.01).Compared with preanesthesia,MMSE scores decreased significantly at 3 hours after operation in PPST group(P 0.01) and the control group decreased significantly at 3,6 and 24 hours after operation(P 0.01),the differeces of MMSE scores in two groups were not statistical significance at 72 hours after operation(P 0.05).MMSE scores of control group were lower than that in PPST group at 3,6 and 24 hours after operation(P 0.05 to P 0.01).Conclusions: Perioperative psychological support therapy can significantly reduce the incidence of postoperative cognitive dysfunction of elderly patient with femoral neck fracture and improve the relative stability of patients' circulation before and after the extubation,which keep patient stable during perioperative period.
2013, 37(5): 534-535,538.
Abstract:
Objective: To evaluate the effect of cornesocleral limbus autotransplantation combined with amnion covering and mitomycin C in treatment of recurrent pterygium.Methods: The ulcer polyp in 21 cases(21 eyes) of recurrent pterygium were removed,and then a piece of absorbent cotton containing 0.02% mitomycin C was put on the exposed area of the sclera for two minutes;after fully washed with 0.9% normal saline,the whole surface of the cornea and sclera was covered with a large piece of preserved amnion;the conjunctiva with corneal limbus epithelium was sutured on the limbus above the amnion.All the patients were followed up for three years.Results: The postoperative symptoms in the 21 cases were slight,which disappeared after one week.Two to four weeks later,the amnion was absorbed.The pterygium recurred in two cases during the follow-up period.Conclusions: Cornesocleral limbus autotransplantation combined with amnion covering and mitomycin C is safe and effective for treatment of recurrent pterygium with low recurrences and slight postoperative symptoms.
Objective: To evaluate the effect of cornesocleral limbus autotransplantation combined with amnion covering and mitomycin C in treatment of recurrent pterygium.Methods: The ulcer polyp in 21 cases(21 eyes) of recurrent pterygium were removed,and then a piece of absorbent cotton containing 0.02% mitomycin C was put on the exposed area of the sclera for two minutes;after fully washed with 0.9% normal saline,the whole surface of the cornea and sclera was covered with a large piece of preserved amnion;the conjunctiva with corneal limbus epithelium was sutured on the limbus above the amnion.All the patients were followed up for three years.Results: The postoperative symptoms in the 21 cases were slight,which disappeared after one week.Two to four weeks later,the amnion was absorbed.The pterygium recurred in two cases during the follow-up period.Conclusions: Cornesocleral limbus autotransplantation combined with amnion covering and mitomycin C is safe and effective for treatment of recurrent pterygium with low recurrences and slight postoperative symptoms.
2013, 37(5): 536-538.
Abstract:
Objective: To investigate the clinic characteristics,diagnosis and treatment of tuberculosis in patients with systemic lupus erythematosus(SLE).Methods: The data of 39 SLE patients with tuberculosis were analyzed retrospectively including the clinic manifestations,imaging data,laboratory examination results,diagnosis and treatment conditions.Results: In 39 SLE patients with tuberculosis,pulmonary tuberculosis were happened in 18 cases,extrapulmonary tuberculosis in 19 cases,pulmonary tuberculosis complicated with extrapulmonary tuberculosis in 2 cases.Tuberculosis in SLE patients with complex and diverse clinical manifestations such as fever was occurred in 39 cases,lack of power in 37 patients,night sweats in 25 cases,cough in 20 cases.All patients were using anti-tuberculosis treatment after diagnosis,the treatment course was 9 months to 1.5 years.Three cases was dead,the remaining patients tended to cure by the standardized treatment of tuberculosis disease.Conclusions: Tuberculosis in patients with SLE has complex and varied clinic symptoms,it's different from simple tuberculosis and typical SLE.It is needed to notice if there was combined with other pathogens infection.Treatment needs to give consideration to the basic disease and tuberculosis.Early diagnosis and standardization of anti-tuberculosis are the important means which can improve the prognosis.
Objective: To investigate the clinic characteristics,diagnosis and treatment of tuberculosis in patients with systemic lupus erythematosus(SLE).Methods: The data of 39 SLE patients with tuberculosis were analyzed retrospectively including the clinic manifestations,imaging data,laboratory examination results,diagnosis and treatment conditions.Results: In 39 SLE patients with tuberculosis,pulmonary tuberculosis were happened in 18 cases,extrapulmonary tuberculosis in 19 cases,pulmonary tuberculosis complicated with extrapulmonary tuberculosis in 2 cases.Tuberculosis in SLE patients with complex and diverse clinical manifestations such as fever was occurred in 39 cases,lack of power in 37 patients,night sweats in 25 cases,cough in 20 cases.All patients were using anti-tuberculosis treatment after diagnosis,the treatment course was 9 months to 1.5 years.Three cases was dead,the remaining patients tended to cure by the standardized treatment of tuberculosis disease.Conclusions: Tuberculosis in patients with SLE has complex and varied clinic symptoms,it's different from simple tuberculosis and typical SLE.It is needed to notice if there was combined with other pathogens infection.Treatment needs to give consideration to the basic disease and tuberculosis.Early diagnosis and standardization of anti-tuberculosis are the important means which can improve the prognosis.
2013, 37(5): 539-542.
Abstract:
Objective: To observe the levels of interleukin-18(IL-18) and monocyte chemoattractantprotein-1(MCP-1) in polycystic ovary syndrome(PCOS) patients and to explore that the concentrations of IL-18 and MCP-1 were abnormal in PCOS,and that these cytokines were relevant to insulin resistance or obesity.Methods: Forty-seven PCOS patients(PCOS group) and 29 healthy volunteers(control group) were included in the study.The PCOS patients were divided into two sub groups according to the body mass index(BMI) and homeostasis model assessment(HOMA-IR).According to BMI,30 patients were included in the obese group and 17 in nonobese group;according to Homa-IR,18 patients were included in the insulin resistant group and 29 in non-insulin resistant group.The IL-18 and MCP-1 were compared in each group.The correlation between IL-18,MCP-1 and BMI,waist-hip ratio(WHR),HOMA-IR were also analyzed in the PCOS patients.Results: The levels of IL-18 and MCP-1 in the PCOS IR group and the obese group were significantly higher than those in the non-insulin resistant PCOS group and the non-obese PCOS group(P 0.01).IL-18 levels were positively correlated with BMI and HOMA-IR;MCP-1 levels were positively correlated with BMI,WHR and HOMA-IR(P 0.01).Conclusions: The levels of IL-18 and MCP-1 in PCOS patients increase significantly,which is correlated with IR and obesity.
Objective: To observe the levels of interleukin-18(IL-18) and monocyte chemoattractantprotein-1(MCP-1) in polycystic ovary syndrome(PCOS) patients and to explore that the concentrations of IL-18 and MCP-1 were abnormal in PCOS,and that these cytokines were relevant to insulin resistance or obesity.Methods: Forty-seven PCOS patients(PCOS group) and 29 healthy volunteers(control group) were included in the study.The PCOS patients were divided into two sub groups according to the body mass index(BMI) and homeostasis model assessment(HOMA-IR).According to BMI,30 patients were included in the obese group and 17 in nonobese group;according to Homa-IR,18 patients were included in the insulin resistant group and 29 in non-insulin resistant group.The IL-18 and MCP-1 were compared in each group.The correlation between IL-18,MCP-1 and BMI,waist-hip ratio(WHR),HOMA-IR were also analyzed in the PCOS patients.Results: The levels of IL-18 and MCP-1 in the PCOS IR group and the obese group were significantly higher than those in the non-insulin resistant PCOS group and the non-obese PCOS group(P 0.01).IL-18 levels were positively correlated with BMI and HOMA-IR;MCP-1 levels were positively correlated with BMI,WHR and HOMA-IR(P 0.01).Conclusions: The levels of IL-18 and MCP-1 in PCOS patients increase significantly,which is correlated with IR and obesity.
2013, 37(5): 542-544.
Abstract:
Objective: To analyze the relationship between serum osteoprotegerin(OPG) and glycated hemoglobin(HbA1c) levels in patients with acute coronary syndrome(ACS).Methods: Eighty-eight patients were classified into control group,stable angina pectoris(SAP) group and ACS group.Serum OPG and HbA1c levels were measured upon hospital admission and divided into 1-,2-,3-vessel disease groups according to the numbers of narrowed coronary vessels under coronary angiography.The relationships of serum OPG and HbA1c levels and coronary stenosis degree according to Gensini score were analyzed.Results: Serum OPG and HbA1c levels in ACS group were significantly higher than in control group(P 0.01),and OPG and HbA1c levels were increased significantly with the severity degree of ACS(P 0.05-P 0.01).A positive relationship was found between OPG level and Gensini score(P 0.01),and a positive correlation was also found between HbA1c level and Gensini score(P 0.01).OPG level was positively correlated with HbA1c level(P 0.01).Conclusions: Serum OPG and HbA1c levels were related with the severity of ACS.
Objective: To analyze the relationship between serum osteoprotegerin(OPG) and glycated hemoglobin(HbA1c) levels in patients with acute coronary syndrome(ACS).Methods: Eighty-eight patients were classified into control group,stable angina pectoris(SAP) group and ACS group.Serum OPG and HbA1c levels were measured upon hospital admission and divided into 1-,2-,3-vessel disease groups according to the numbers of narrowed coronary vessels under coronary angiography.The relationships of serum OPG and HbA1c levels and coronary stenosis degree according to Gensini score were analyzed.Results: Serum OPG and HbA1c levels in ACS group were significantly higher than in control group(P 0.01),and OPG and HbA1c levels were increased significantly with the severity degree of ACS(P 0.05-P 0.01).A positive relationship was found between OPG level and Gensini score(P 0.01),and a positive correlation was also found between HbA1c level and Gensini score(P 0.01).OPG level was positively correlated with HbA1c level(P 0.01).Conclusions: Serum OPG and HbA1c levels were related with the severity of ACS.
2013, 37(5): 545-549.
Abstract:
Objective: To explore the correlation between human intestinal fatty acid binding protein 2(FABP2) polymorphism and the metabolism of type 2 diabetic patients and their non-diabetic first-degree relatives.Methods: Two hundred and twenty-four patients with type 2 diabetes mellitus(T2DM) and their 84 non-diabetic first degree relatives(NDR),60 healthy person were divided into the T2DM,NDR and NC group,respectively.The restricted fragment length polymorphisms of Hha Ⅰ enzyme site in codon 54 of the intestinal FABP gene of three groups were analysed by PCR.Results: The polymorphic sites of FABP2 HhaⅠincluding Ala54Ala and Ala54Thr of FABP2 and Thr54Thr polymorphism fragment were found in three groups.The allele freqencies of Ala54 and thr54 were 0.67 and 0.33,respectively.Compared with NC group,the insulin resistance(IR) index,fasting insulin,and the levels of triglyceride(TG),total cholesterol(TC) and low density lipoprotein(LDL) increased significantly(P 0.01),the insulin sensitivity index and the level of high density lipoprotein(HDL) decreased significantly in T2DM group(P 0.01).Compared with patients with FABP2 Thr(-) genotype of T2DM group,the FINS,IR index,and the levels of fasting blood glucose(FBG),TG and LDL increased significantly(P 0.01),the insulin sensitivity index and the level of HDL decreased significantly in patients with FABP2 Thr(+) genotype(FABP2 Ala54Ala,Ala54Thr and Thr54Thr) of T2DM group(P 0.01).Compared to patients with FABP2 Thr(-) genotype of NDR group,the IR index and the level of TG increased significantly(P 0.01 and P 0.05),the insulin sensitivity index decreased significantly in patients with FABP2 Thr(+) genotype of T2DM group(P 0.01).Conclusions: The Han has FABP2 polymorphism in Bengbu.The IR and abnormal lipid metabolism exist in T2DM and NDR group.The FABP2 Thr(+) genotypes in T2DM and NDR groups are related to IR,which is one factor of abnormal lipid metabolism.
Objective: To explore the correlation between human intestinal fatty acid binding protein 2(FABP2) polymorphism and the metabolism of type 2 diabetic patients and their non-diabetic first-degree relatives.Methods: Two hundred and twenty-four patients with type 2 diabetes mellitus(T2DM) and their 84 non-diabetic first degree relatives(NDR),60 healthy person were divided into the T2DM,NDR and NC group,respectively.The restricted fragment length polymorphisms of Hha Ⅰ enzyme site in codon 54 of the intestinal FABP gene of three groups were analysed by PCR.Results: The polymorphic sites of FABP2 HhaⅠincluding Ala54Ala and Ala54Thr of FABP2 and Thr54Thr polymorphism fragment were found in three groups.The allele freqencies of Ala54 and thr54 were 0.67 and 0.33,respectively.Compared with NC group,the insulin resistance(IR) index,fasting insulin,and the levels of triglyceride(TG),total cholesterol(TC) and low density lipoprotein(LDL) increased significantly(P 0.01),the insulin sensitivity index and the level of high density lipoprotein(HDL) decreased significantly in T2DM group(P 0.01).Compared with patients with FABP2 Thr(-) genotype of T2DM group,the FINS,IR index,and the levels of fasting blood glucose(FBG),TG and LDL increased significantly(P 0.01),the insulin sensitivity index and the level of HDL decreased significantly in patients with FABP2 Thr(+) genotype(FABP2 Ala54Ala,Ala54Thr and Thr54Thr) of T2DM group(P 0.01).Compared to patients with FABP2 Thr(-) genotype of NDR group,the IR index and the level of TG increased significantly(P 0.01 and P 0.05),the insulin sensitivity index decreased significantly in patients with FABP2 Thr(+) genotype of T2DM group(P 0.01).Conclusions: The Han has FABP2 polymorphism in Bengbu.The IR and abnormal lipid metabolism exist in T2DM and NDR group.The FABP2 Thr(+) genotypes in T2DM and NDR groups are related to IR,which is one factor of abnormal lipid metabolism.
2013, 37(5): 549-551.
Abstract:
Objective: To explore the clinicopathological characteristics,the diagnosis and differential diagnosis of aggressive angiomyxoma(AAM).Methods: One case with AAM of pelvic cavity was detected by light microscopy and immunohistochemistry,and the literatures about AAM were reviewed.Results: The high expressions of vimentin,desmin and CD34,and partial expression of SMA were detected by immunohistochemistry in tumor tissue of AAM.Conclusions: The clinical symptoms of AAM are concealed.It is difficult to achieve completely resection by surgery and postoperative recurrence is common.The correct diagnosis can be decided by its pathological characteristics and immunophenotype.
Objective: To explore the clinicopathological characteristics,the diagnosis and differential diagnosis of aggressive angiomyxoma(AAM).Methods: One case with AAM of pelvic cavity was detected by light microscopy and immunohistochemistry,and the literatures about AAM were reviewed.Results: The high expressions of vimentin,desmin and CD34,and partial expression of SMA were detected by immunohistochemistry in tumor tissue of AAM.Conclusions: The clinical symptoms of AAM are concealed.It is difficult to achieve completely resection by surgery and postoperative recurrence is common.The correct diagnosis can be decided by its pathological characteristics and immunophenotype.
2013, 37(5): 552-554.
Abstract:
Objective: To sum the experience of treatment on kidney neoplasms with radical nephrectomy through retroperitoneal laparoscopy.Methods: The clinical data of 21 cases with kidney neoplasms treatment by radical nephrectomy through retroperitoneal laparoscopy were retrospectively analyzed.Results: All operations were performed successfully.The operation time for 120 180 minutes,the bleeding volume for 100-200 ml,removing drainage tube time for 2-3 days and hospitalization time for 5-7 days were recorded.No recurrence,metastasis and implantation of tumor were found after following-up for 1-36 months.Conclusions: Treatment kidney neoplasms with radical nephrectomy through retroperitoneal laparoscopy is a safe and effective method,which is worthy of being widely applied in clinic.
Objective: To sum the experience of treatment on kidney neoplasms with radical nephrectomy through retroperitoneal laparoscopy.Methods: The clinical data of 21 cases with kidney neoplasms treatment by radical nephrectomy through retroperitoneal laparoscopy were retrospectively analyzed.Results: All operations were performed successfully.The operation time for 120 180 minutes,the bleeding volume for 100-200 ml,removing drainage tube time for 2-3 days and hospitalization time for 5-7 days were recorded.No recurrence,metastasis and implantation of tumor were found after following-up for 1-36 months.Conclusions: Treatment kidney neoplasms with radical nephrectomy through retroperitoneal laparoscopy is a safe and effective method,which is worthy of being widely applied in clinic.
2013, 37(5): 554-556.
Abstract:
Objective: To investigate the rational application of the positive end-expiratory pressure(PEEP) mechanical ventilation in severe acute phosgene poisoning.Methods: The data of arterial blood gas,oxygenation index(PaO2/ Fi2),blood pressure,respiratory rate(R) of 7 cases with severe acute phosgene poisoning treated with different PEEP were analysed.Results: The pH value,PaCO2,PaO2/ Fi2 and R of 7 patients were obviously improved after PEEP mechanical ventilation based on the basic treatment(P 0.01),and which efficiency were 100%.Conclusions: The reasonable application of PEEP in patients with severe acute phosgene poisoning can improve oxygenation index and increase cure rate.
Objective: To investigate the rational application of the positive end-expiratory pressure(PEEP) mechanical ventilation in severe acute phosgene poisoning.Methods: The data of arterial blood gas,oxygenation index(PaO2/ Fi2),blood pressure,respiratory rate(R) of 7 cases with severe acute phosgene poisoning treated with different PEEP were analysed.Results: The pH value,PaCO2,PaO2/ Fi2 and R of 7 patients were obviously improved after PEEP mechanical ventilation based on the basic treatment(P 0.01),and which efficiency were 100%.Conclusions: The reasonable application of PEEP in patients with severe acute phosgene poisoning can improve oxygenation index and increase cure rate.
2013, 37(5): 557-559.
Abstract:
Objective: To compare the clinical effects of four kinds of hysterectomy and investigate the available way for hysterectomy.Methods: The clinical data of 36 cases were treated with total laparoscopic hysterectomy(TLH group),41 cases were treated with transabdominal hysterectomy(TAH group),40 cases were treated with transvaginal hysterectomy(TVH group) and 42 cases were treated with laparoscope assisted vaginal hysterectomy(LAVH group) were retrospectively analysed.The time of operation,recovery,using antibiotics and hospitalization,the intraoperative bleeding loss,the incidence of complications and the hospitalization expenses of all cases were compared.Results: Among the four groups,there were significant difference in the time of operation(P 0.01) and there was no significant difference in the the intraoperative bleeding loss(P 0.05).The time of postoperative anal exhaust,the leaving bed,the body temperature recovery,hospitalization and using anticiotics and the postoperative pain degrees in TAH group were longer and heavier than that in TVH,LAVH and TLH group(P 0.01).The hospitalization expenses of TAH group and TVH group were less than that in LAVH or TLH group(P 0.01).Conclusions: Four kinds of operation are safe and feasible,which have own advantages and disadvantages.TLH can be a majoy way of hysterectomy.Proper mean should be chosed according to patients' physical condition and the operation doctors' skill.
Objective: To compare the clinical effects of four kinds of hysterectomy and investigate the available way for hysterectomy.Methods: The clinical data of 36 cases were treated with total laparoscopic hysterectomy(TLH group),41 cases were treated with transabdominal hysterectomy(TAH group),40 cases were treated with transvaginal hysterectomy(TVH group) and 42 cases were treated with laparoscope assisted vaginal hysterectomy(LAVH group) were retrospectively analysed.The time of operation,recovery,using antibiotics and hospitalization,the intraoperative bleeding loss,the incidence of complications and the hospitalization expenses of all cases were compared.Results: Among the four groups,there were significant difference in the time of operation(P 0.01) and there was no significant difference in the the intraoperative bleeding loss(P 0.05).The time of postoperative anal exhaust,the leaving bed,the body temperature recovery,hospitalization and using anticiotics and the postoperative pain degrees in TAH group were longer and heavier than that in TVH,LAVH and TLH group(P 0.01).The hospitalization expenses of TAH group and TVH group were less than that in LAVH or TLH group(P 0.01).Conclusions: Four kinds of operation are safe and feasible,which have own advantages and disadvantages.TLH can be a majoy way of hysterectomy.Proper mean should be chosed according to patients' physical condition and the operation doctors' skill.
2013, 37(5): 560-562.
Abstract:
Objective: To explore the curative effects of ultra-early extended craniotomy on hypertensive cerebral hemorrhage.Methods: Thirty-eight patients with hypertensive cerebral hemorrhage combined with cerebral hernia were performed hematoma evacuation and decompression through extended craniotomy within 6 hours injury the attack.Patients combined with intraventricular hemorrhage were treated by cerebral ventricle drainage as well as tracheotomy and mechanical ventilator when necessary.Nutritional support was applied to prevent infection and complications;the inner environment was detected;head CT was routinely reviewed after the operation.Results: Hematomas were basically evacuated and 13 patients died after the operation.Conclusions: Ultra-early decompression by extended craniotomy can reduce the mortality in patients with hypertensive cerebral hemorrhage combined with cerebral hernia.
Objective: To explore the curative effects of ultra-early extended craniotomy on hypertensive cerebral hemorrhage.Methods: Thirty-eight patients with hypertensive cerebral hemorrhage combined with cerebral hernia were performed hematoma evacuation and decompression through extended craniotomy within 6 hours injury the attack.Patients combined with intraventricular hemorrhage were treated by cerebral ventricle drainage as well as tracheotomy and mechanical ventilator when necessary.Nutritional support was applied to prevent infection and complications;the inner environment was detected;head CT was routinely reviewed after the operation.Results: Hematomas were basically evacuated and 13 patients died after the operation.Conclusions: Ultra-early decompression by extended craniotomy can reduce the mortality in patients with hypertensive cerebral hemorrhage combined with cerebral hernia.
2013, 37(5): 562-564.
Abstract:
Objective: To explore the effects of early enteral nutrition(EEN) on the nutritional support of postoperative patients with upper gastrointestinal tract tumor.Methods: Sixty-four and 56 cases with upper gastrointestinal tract tumor were treated with elemental diet through nasointestinal tube(EEN group) and traditional parenteral nutrition(PN group) at 24 h after operation,respectively.The levels of serum albumin(ALB) and prealbumin(PA) in two groups were observed at 1 day before operation and 6 days after operation.The time of the first time postoperative gastrointestinal exhaust,the related complication during the period of early enteral nutrition and postoperative complication were observed.Results: The preoperative levels of ALB and PA in two groups were not statistic significance(P 0.05).The postoperative levels of ALB and PA in two groups decreased obviously,the decreasing degree of PN group was higher than that in EEN group(P 0.01).The time of the first postoperative gastrointestinal exhaust in EEN group was earlier than that in PN group(P 0.01).The incidence of postoperative complication in EEN group(13.4%) was significantly lower than that in PN group(34.2%)(P 0.01).Conclusions: The EEN is safe and effective in the nutritional support of postoperative patients with upper gastrointestinal tract tumor.Promoting the patient gastrointestinal function early recovery and protecting intestinal mucosa normal digest function can reduce the postoperative patient infusion load.
Objective: To explore the effects of early enteral nutrition(EEN) on the nutritional support of postoperative patients with upper gastrointestinal tract tumor.Methods: Sixty-four and 56 cases with upper gastrointestinal tract tumor were treated with elemental diet through nasointestinal tube(EEN group) and traditional parenteral nutrition(PN group) at 24 h after operation,respectively.The levels of serum albumin(ALB) and prealbumin(PA) in two groups were observed at 1 day before operation and 6 days after operation.The time of the first time postoperative gastrointestinal exhaust,the related complication during the period of early enteral nutrition and postoperative complication were observed.Results: The preoperative levels of ALB and PA in two groups were not statistic significance(P 0.05).The postoperative levels of ALB and PA in two groups decreased obviously,the decreasing degree of PN group was higher than that in EEN group(P 0.01).The time of the first postoperative gastrointestinal exhaust in EEN group was earlier than that in PN group(P 0.01).The incidence of postoperative complication in EEN group(13.4%) was significantly lower than that in PN group(34.2%)(P 0.01).Conclusions: The EEN is safe and effective in the nutritional support of postoperative patients with upper gastrointestinal tract tumor.Promoting the patient gastrointestinal function early recovery and protecting intestinal mucosa normal digest function can reduce the postoperative patient infusion load.
2013, 37(5): 565-568,571.
Abstract:
Objective: To evaluate the clinical value of intrapleural perfusion of interleukin-2(IL-2),cisplatin(DDP) or the combined therapy for malignant pleural effusion(MPE) patient.Methods: A pooled analysis was taken which based on the data of efficacy and toxicity of treatments in 3 778 MPE patients from 1993 to 2009,1 499 patients were treated with IL-2 alone,708 patients were treated with cisplatin alone,and 1 571 patients were treated by the combined therapy.The clinic randomized control trail data were screened according to the standard of randomized study without other therapies.Three hundred thirty and five patients were in the IL-2 group,513 patients were in the DDP group and 460 patients were in the combined therapy group.Results: In non-randomized study,the effective rate in IL-2 group was 80.05%,the combined therapy group was 81.41%,which were higher than in DDP group with 58.05%.The adverse reaction rates including heating,bone marrow toxicity,chest pain,gastrointestinal reaction,hepatotoxic and nephrotoxicity had significant differences(P 0.01).In randomized study,the effective rate in IL-2 group was 77.01% and the combined therapy group was 84.13%,which were higher than in DDP group with 58.67%(P 0.05).The adverse reaction rates including heating,bone marrow toxicity,chest pain,gastrointestinal reaction,hepatotoxic and nephrotoxicity had significant differences(P 0.01) among 3 groups in randomized study.Conclusions: It has a good effective therapy with IL-2 alone and well tolerated for MPE patients,which could improve the quality of life.
Objective: To evaluate the clinical value of intrapleural perfusion of interleukin-2(IL-2),cisplatin(DDP) or the combined therapy for malignant pleural effusion(MPE) patient.Methods: A pooled analysis was taken which based on the data of efficacy and toxicity of treatments in 3 778 MPE patients from 1993 to 2009,1 499 patients were treated with IL-2 alone,708 patients were treated with cisplatin alone,and 1 571 patients were treated by the combined therapy.The clinic randomized control trail data were screened according to the standard of randomized study without other therapies.Three hundred thirty and five patients were in the IL-2 group,513 patients were in the DDP group and 460 patients were in the combined therapy group.Results: In non-randomized study,the effective rate in IL-2 group was 80.05%,the combined therapy group was 81.41%,which were higher than in DDP group with 58.05%.The adverse reaction rates including heating,bone marrow toxicity,chest pain,gastrointestinal reaction,hepatotoxic and nephrotoxicity had significant differences(P 0.01).In randomized study,the effective rate in IL-2 group was 77.01% and the combined therapy group was 84.13%,which were higher than in DDP group with 58.67%(P 0.05).The adverse reaction rates including heating,bone marrow toxicity,chest pain,gastrointestinal reaction,hepatotoxic and nephrotoxicity had significant differences(P 0.01) among 3 groups in randomized study.Conclusions: It has a good effective therapy with IL-2 alone and well tolerated for MPE patients,which could improve the quality of life.
2013, 37(5): 569-571.
Abstract:
Objective: To investigate the clinical effects of progynova or mifepristone combined with rivanol on induced abortion of midtrimester pregnancy.Methods: Two hundred and twenty-six cases with induced abortion of midtrimester pregnancy were randomly divided into three groups.The first group(68 cases) were aborted with progynova combined with rivanol,the second group(92 cases) were aborted with mifepristone combined with rivanol and the control group(66 cases) were aborted with only rivanol.The clinical effects and blood loss of all cases were compared.Results: Compared with the control group,the time of embryo delivery of the first and second group shorten significantly(P 0.01).The blood loss of the first group decresed significantly(P 0.05).Conclusions: The effects of progynova or mifepristone combined with rivanol on induced abortion of midtrimester pregnancy were better than that of rivanol.The treatment of progynova combined with rivanol can reduce the blood loss,which is worth popularizing application in clinic.
Objective: To investigate the clinical effects of progynova or mifepristone combined with rivanol on induced abortion of midtrimester pregnancy.Methods: Two hundred and twenty-six cases with induced abortion of midtrimester pregnancy were randomly divided into three groups.The first group(68 cases) were aborted with progynova combined with rivanol,the second group(92 cases) were aborted with mifepristone combined with rivanol and the control group(66 cases) were aborted with only rivanol.The clinical effects and blood loss of all cases were compared.Results: Compared with the control group,the time of embryo delivery of the first and second group shorten significantly(P 0.01).The blood loss of the first group decresed significantly(P 0.05).Conclusions: The effects of progynova or mifepristone combined with rivanol on induced abortion of midtrimester pregnancy were better than that of rivanol.The treatment of progynova combined with rivanol can reduce the blood loss,which is worth popularizing application in clinic.
2013, 37(5): 572-574.
Abstract:
Objective: To investigate and analyze the characteristics of diabetes incidence in relocation residents in Tiexinqiao community of Nanjing.Methods: The Nanjing diabetes center was cooperated with center for disease control in Yuhuatai and community health service center of Tiexinqiao.Through showbill,notice and other ways,the study recruited the people who were relocated in Tiexinqiao community from Nanjing other areas with decommissioned houses or cropland occupation.These people were not diagnosed as diabetes.Demography and history data were recorded.Height,weight,abdominal circumference,waistline,blood pressure and blood glucose level were tested.These people whose fast blood glucose 5.0 mmol / L or random blood glucose 7.0mmol / L were suggested to do 75 g oral glucose tolerance test,and blood glucose level at 0,30,120 min were measured.Results: Five hundred and forty participants were randomly recruited.The incidence of diabetes,impaired glucose tolerance and impaired fast glucose tolerance were 6.85%,5.56% and 3.15% respectively in these people who had no history of diabetes.The correlation analysis indicated that income,body mass index,durations of hypertension,waistline,hip circumference and waistline / hip circumference value were no correlated with the incidence of diabetes(P 0.05).Conclusions: The diabetes incidence of relocated residents is higher than general level,the diabetes screening should be strengthen in these people.
Objective: To investigate and analyze the characteristics of diabetes incidence in relocation residents in Tiexinqiao community of Nanjing.Methods: The Nanjing diabetes center was cooperated with center for disease control in Yuhuatai and community health service center of Tiexinqiao.Through showbill,notice and other ways,the study recruited the people who were relocated in Tiexinqiao community from Nanjing other areas with decommissioned houses or cropland occupation.These people were not diagnosed as diabetes.Demography and history data were recorded.Height,weight,abdominal circumference,waistline,blood pressure and blood glucose level were tested.These people whose fast blood glucose 5.0 mmol / L or random blood glucose 7.0mmol / L were suggested to do 75 g oral glucose tolerance test,and blood glucose level at 0,30,120 min were measured.Results: Five hundred and forty participants were randomly recruited.The incidence of diabetes,impaired glucose tolerance and impaired fast glucose tolerance were 6.85%,5.56% and 3.15% respectively in these people who had no history of diabetes.The correlation analysis indicated that income,body mass index,durations of hypertension,waistline,hip circumference and waistline / hip circumference value were no correlated with the incidence of diabetes(P 0.05).Conclusions: The diabetes incidence of relocated residents is higher than general level,the diabetes screening should be strengthen in these people.
2013, 37(5): 575-576,578.
Abstract:
Objective: To assess the Influence of sperm DNA damage on the outcomes in vitro fertilization(IVF) and intracytoplasmic sperm injection(ICSI).Methods: The sperm DNA damage level of the infertile men undergoing IVF or ICSI was detected by the sperm chromatin dispersion test,and they were divided into two groups by the sperm DNA damage level 15%.The fertilization rate,good quality embryo rate,live birth rate and abortion rate of the two groups were observed and compared.Results: The sperm density,sperm motility,normal sperm morphology,sperm acrosomal enzyme,good quality embryo rate and live birth rate in DNA damage group were significantly lower than the variables in normal group(P 0.01),the ICSI fertilization rate in DNA damage group was significantly higher than that in normal group(P 0.01).There was no significant difference on statistic in the abortion rate between the two groups(P 0.05).Conclusions: Sperm DNA damage detection may help to predict the outcome of IVF and ICSI to a certain extent.
Objective: To assess the Influence of sperm DNA damage on the outcomes in vitro fertilization(IVF) and intracytoplasmic sperm injection(ICSI).Methods: The sperm DNA damage level of the infertile men undergoing IVF or ICSI was detected by the sperm chromatin dispersion test,and they were divided into two groups by the sperm DNA damage level 15%.The fertilization rate,good quality embryo rate,live birth rate and abortion rate of the two groups were observed and compared.Results: The sperm density,sperm motility,normal sperm morphology,sperm acrosomal enzyme,good quality embryo rate and live birth rate in DNA damage group were significantly lower than the variables in normal group(P 0.01),the ICSI fertilization rate in DNA damage group was significantly higher than that in normal group(P 0.01).There was no significant difference on statistic in the abortion rate between the two groups(P 0.05).Conclusions: Sperm DNA damage detection may help to predict the outcome of IVF and ICSI to a certain extent.
2013, 37(5): 577-578.
Abstract:
Objective: To evaluate the value of video-assisted thoracoscopic surgery(VATS) in the diagnosis and treatment of emergent traumatic hemopneumothorax.Methods: Thirty-one cases with traumatic hemopneumothorax caused by intercostal vascular rupture and lung tissue laceration were probed,stopped bleeding and repaired by VATS.Results: The operation of 31 patients were successful,and no fatality and complications occured.The time of operation,pleural cavity drainage and hospitalization were 27-101 minutes,1-3 days and 4-10 days,respectively.Conclusions: VATS is a safe,effective and less invasive method to diagnose and treat traumatic hemopneumothorax,but surgical indications should be strictly controlled.
Objective: To evaluate the value of video-assisted thoracoscopic surgery(VATS) in the diagnosis and treatment of emergent traumatic hemopneumothorax.Methods: Thirty-one cases with traumatic hemopneumothorax caused by intercostal vascular rupture and lung tissue laceration were probed,stopped bleeding and repaired by VATS.Results: The operation of 31 patients were successful,and no fatality and complications occured.The time of operation,pleural cavity drainage and hospitalization were 27-101 minutes,1-3 days and 4-10 days,respectively.Conclusions: VATS is a safe,effective and less invasive method to diagnose and treat traumatic hemopneumothorax,but surgical indications should be strictly controlled.
2013, 37(5): 579-580.
Abstract:
Objective: To observe the effects on marzulene combined with omeprazole,amoxicillin and clarithromycin in the treatment of peptic ulcer and eliminating the infection of Helicobacter pylori(Hp).Methods: One hundred and fifty-eight peptic ulcer patients(including gastric ulcer and duodenal ulcer) were diagnosed by gastroscope,and their rapid urease tests were positive.All patients were randomly divided into treatment group(80 cases) and control group(78 cases).All patients took 20 mg omeprazole,1.0 g amoxicillinand and 0.5 g clarithromycin twice a day for 14 days by oral.The treatment groups were added 0.67 g of marzulene three times a day for 14 days.The ulcer healing and Hp clearance rates of all patients were observed by gastroscope and rapid urease test.Results: The ulcer healing and Hp clearance rates of the treatment and control group were 92.50% 87.50% vs 67.95% 60.26%,respectively,the differences on statistic were significantly(P 0.01).Conclusions: The effects and Hp clearance rates of marzulene combined with omeprazole,amoxicillin and clarithromycin in the treatment of peptic ulcer are befter and highe,this is a safe and effective therapy way.
Objective: To observe the effects on marzulene combined with omeprazole,amoxicillin and clarithromycin in the treatment of peptic ulcer and eliminating the infection of Helicobacter pylori(Hp).Methods: One hundred and fifty-eight peptic ulcer patients(including gastric ulcer and duodenal ulcer) were diagnosed by gastroscope,and their rapid urease tests were positive.All patients were randomly divided into treatment group(80 cases) and control group(78 cases).All patients took 20 mg omeprazole,1.0 g amoxicillinand and 0.5 g clarithromycin twice a day for 14 days by oral.The treatment groups were added 0.67 g of marzulene three times a day for 14 days.The ulcer healing and Hp clearance rates of all patients were observed by gastroscope and rapid urease test.Results: The ulcer healing and Hp clearance rates of the treatment and control group were 92.50% 87.50% vs 67.95% 60.26%,respectively,the differences on statistic were significantly(P 0.01).Conclusions: The effects and Hp clearance rates of marzulene combined with omeprazole,amoxicillin and clarithromycin in the treatment of peptic ulcer are befter and highe,this is a safe and effective therapy way.
2013, 37(5): 581-582.
Abstract:
Objective: To investigate the clinical value of the short-term conservative method combined with the procedure for prolapse and hemorrhoids(PPH) in the treatment of acute incarceration circumferential mixed hemorrhoids.Methods: Twenty-five patients with acute incarceration circumferential mixed hemorrhoids were treated with PPH after the conservative therapy.The effects and complications of postoperation were analysed.Results: All patients were cured,and the operation time was 15 to 35 minutes.The time of preoperative treatment and postoperative hospitalization were 3 to 6 and 3 to 5 days,respectively.The postoperative analgesics were employed in 10 cases.No massive haemorrhage,infection and anal incontinence and stenosis were found after operation.Conclusions: The short-time conservative method combined with PPH for patient with acute incarceration circumferential mixed hemorrhoids is safe and effective,which is short operation time,quick rehabilitation and less complications.
Objective: To investigate the clinical value of the short-term conservative method combined with the procedure for prolapse and hemorrhoids(PPH) in the treatment of acute incarceration circumferential mixed hemorrhoids.Methods: Twenty-five patients with acute incarceration circumferential mixed hemorrhoids were treated with PPH after the conservative therapy.The effects and complications of postoperation were analysed.Results: All patients were cured,and the operation time was 15 to 35 minutes.The time of preoperative treatment and postoperative hospitalization were 3 to 6 and 3 to 5 days,respectively.The postoperative analgesics were employed in 10 cases.No massive haemorrhage,infection and anal incontinence and stenosis were found after operation.Conclusions: The short-time conservative method combined with PPH for patient with acute incarceration circumferential mixed hemorrhoids is safe and effective,which is short operation time,quick rehabilitation and less complications.
2013, 37(5): 583-585,588.
Abstract:
Objective: To explore the clinicopathological and immunohistoche mical features of primary anorectal malignant melanoma(AMM) as well as its diagnosis and prognosis.Methods: The clinical pathological characteristics of 9 cases of AMM were observed.All the cases were studied by immunohistochemical technique.Results: The clinical manifestations of the 9 cases of AMM were bloody stool,bloody purulent stool,and alteration of bowel habit and bowel trait.Polypoid type tumors were observed in 3 cases,protrude type with ulcer in 4 cases and ulcer type in 2 cases.The histopathological feature of primary melanoma was similar to that of the skin melanoma were classified into epithelioid cell type 5 cases,spindle cell type 1 case,small cell type 2 cases and hemangiopericytoma-like type 1 case.In the immunophenotype melanoma,positive fos-related antigen HMB45 was observed in 8 cases,positive S-100 in 9 cases,positive melanoma-A(MELAN-A) in 7 cases and positive vimentin in 8 cases.No significant difference in the clinicopathogical features and the expression of antigens were observed between the AMM and the skin melanoma.Conclusions: AMM is a rare and highly malignant tumor with poor prognosis and easily misdiagnosed.Detection of HMB45,S-100 and MELAN-A protein may be of help to the diagnosis and differential diagnosis of the tumor.
Objective: To explore the clinicopathological and immunohistoche mical features of primary anorectal malignant melanoma(AMM) as well as its diagnosis and prognosis.Methods: The clinical pathological characteristics of 9 cases of AMM were observed.All the cases were studied by immunohistochemical technique.Results: The clinical manifestations of the 9 cases of AMM were bloody stool,bloody purulent stool,and alteration of bowel habit and bowel trait.Polypoid type tumors were observed in 3 cases,protrude type with ulcer in 4 cases and ulcer type in 2 cases.The histopathological feature of primary melanoma was similar to that of the skin melanoma were classified into epithelioid cell type 5 cases,spindle cell type 1 case,small cell type 2 cases and hemangiopericytoma-like type 1 case.In the immunophenotype melanoma,positive fos-related antigen HMB45 was observed in 8 cases,positive S-100 in 9 cases,positive melanoma-A(MELAN-A) in 7 cases and positive vimentin in 8 cases.No significant difference in the clinicopathogical features and the expression of antigens were observed between the AMM and the skin melanoma.Conclusions: AMM is a rare and highly malignant tumor with poor prognosis and easily misdiagnosed.Detection of HMB45,S-100 and MELAN-A protein may be of help to the diagnosis and differential diagnosis of the tumor.
2013, 37(5): 586-588.
Abstract:
Objective: To explore the effects of the treatment of adult male with urethral simple stenosis with ureteroscopy combined with fascia expander.Methods: Seventeen expansion failure patients with urethral simple stenosis through the conventional metal urethral probe were treated with ureteroscopy combined with fascia expander.Results: Seventeen cases were successfully expanded,the operation time was 15 to 45 minutes.The urination symptoms of all cases were significantly improved after catheter removal.No serious complications were found.Patients were able to urinate normally,which urine lines were normal or close to normal.All cases were followed-up from 3 to 24 months,and met the criteria of clinical cure by the regular expansion of metal expander.The biggest urine flow rate was more than 15 ml / s,and no residual urine in bladder were observed under B ultrasonic examination.Conclusions: The treatment of adult male with urethral simple stenosis with ureteroscopy combined with fascia expander is safe,effective and simple operation,which can be repeatly used and worthy of being widely applied in clinic.
Objective: To explore the effects of the treatment of adult male with urethral simple stenosis with ureteroscopy combined with fascia expander.Methods: Seventeen expansion failure patients with urethral simple stenosis through the conventional metal urethral probe were treated with ureteroscopy combined with fascia expander.Results: Seventeen cases were successfully expanded,the operation time was 15 to 45 minutes.The urination symptoms of all cases were significantly improved after catheter removal.No serious complications were found.Patients were able to urinate normally,which urine lines were normal or close to normal.All cases were followed-up from 3 to 24 months,and met the criteria of clinical cure by the regular expansion of metal expander.The biggest urine flow rate was more than 15 ml / s,and no residual urine in bladder were observed under B ultrasonic examination.Conclusions: The treatment of adult male with urethral simple stenosis with ureteroscopy combined with fascia expander is safe,effective and simple operation,which can be repeatly used and worthy of being widely applied in clinic.
2013, 37(5): 589-591.
Abstract:
Objective: To evaluate the therapy of ribavirin(RBV) plus interferon(IFN) which was made according to the genotype of hepatitis C virus(HCV) and virological response for treatment of hepatitis C.Methods: The genotype of 7 patients with chronic hepatitis C was detected by reverse-transcript PCR.The patients with genotype 1 received the therapy of RBV 1.0-1.2 g / d,P.O combined with per week pegylated interferon ɑ-2a(PEG-IFN ɑ-2a) subcutaneous injection,180 g for 48 weeks,and patients with genotype 2 /3 were treated by RBV(800 mg / d,P.O) combined with per week PEG-IFN ɑ-2a subcutaneous injection,180 g for 24 weeks.The load of HCV RNA was detected after 4,12 and 24 week during the therapy.The treatment period was modified according to the serum levels of HCV RNA.Results: Sustained virological response was observed in all the 7 patients.Conclusions: Modifying the therapy for patients with chronic hepatitis according to the genotype of HCV and the virological response is of vital importance to enhance the antiviral efficacy.
Objective: To evaluate the therapy of ribavirin(RBV) plus interferon(IFN) which was made according to the genotype of hepatitis C virus(HCV) and virological response for treatment of hepatitis C.Methods: The genotype of 7 patients with chronic hepatitis C was detected by reverse-transcript PCR.The patients with genotype 1 received the therapy of RBV 1.0-1.2 g / d,P.O combined with per week pegylated interferon ɑ-2a(PEG-IFN ɑ-2a) subcutaneous injection,180 g for 48 weeks,and patients with genotype 2 /3 were treated by RBV(800 mg / d,P.O) combined with per week PEG-IFN ɑ-2a subcutaneous injection,180 g for 24 weeks.The load of HCV RNA was detected after 4,12 and 24 week during the therapy.The treatment period was modified according to the serum levels of HCV RNA.Results: Sustained virological response was observed in all the 7 patients.Conclusions: Modifying the therapy for patients with chronic hepatitis according to the genotype of HCV and the virological response is of vital importance to enhance the antiviral efficacy.
2013, 37(5): 591-592.
Abstract:
Objective: To assess the value of fundus fluorescence angiogiaphy(FFA) in diagnostic of early diabetic retinopathy(DR) that had failed to be detected by ophthalenosope.Methods: One hundred and one patients(202 eyes) with non-insulin-dependent diabetes mellitus who had been proved to have no DR by ophthalenosope received FFA examination.Results: Forty-five patients(90 eyes) were found to have early DR by FFA.The lesions included capillaries lump,capillary non-perfusion,capillary fluorescence leakage,telangiectasis and macular edema.Conclusions: Fundus fluorecein angiography can detect diabetic retinopathy earlier than ophthalenosope.
Objective: To assess the value of fundus fluorescence angiogiaphy(FFA) in diagnostic of early diabetic retinopathy(DR) that had failed to be detected by ophthalenosope.Methods: One hundred and one patients(202 eyes) with non-insulin-dependent diabetes mellitus who had been proved to have no DR by ophthalenosope received FFA examination.Results: Forty-five patients(90 eyes) were found to have early DR by FFA.The lesions included capillaries lump,capillary non-perfusion,capillary fluorescence leakage,telangiectasis and macular edema.Conclusions: Fundus fluorecein angiography can detect diabetic retinopathy earlier than ophthalenosope.
2013, 37(5): 597-600.
Abstract:
Objective: To judge the compartment model of aminophylline by vessel injection and work out its pharmacokinetic parameters.Methods: The serum theophylline concentration by vessel injection was detected through two wavelength ultrviolet spectrophotometry,and the pharmacokenetic parameters were studied according to the related theory.Results: The compartment model of aminophylline by vessel injection matched the double compartment model,the formula of its pharmacokinetics was C = 14.46e-3.451t+10.40e-0.114t.Conclusions: The serum theophylline concentration could be detected by two wavelength ultraviolate spectrophotometry,its metabolism in body matched the double compartment model,the formula of its pharmacokinetics could also be made out.
Objective: To judge the compartment model of aminophylline by vessel injection and work out its pharmacokinetic parameters.Methods: The serum theophylline concentration by vessel injection was detected through two wavelength ultrviolet spectrophotometry,and the pharmacokenetic parameters were studied according to the related theory.Results: The compartment model of aminophylline by vessel injection matched the double compartment model,the formula of its pharmacokinetics was C = 14.46e-3.451t+10.40e-0.114t.Conclusions: The serum theophylline concentration could be detected by two wavelength ultraviolate spectrophotometry,its metabolism in body matched the double compartment model,the formula of its pharmacokinetics could also be made out.
2013, 37(5): 602-603.
Abstract:
Objective: To improve the sample processing method of vitamin B12 tablets content determination.Methods: Take vitamin B12 55 pieces,make 1 ml solution contain about 12.5 g vitamin B12.Detect the absorbance by UV spectrophotometry with the wavelength of 361 nm.Results: When vitamin B12 content was in the range of 1.25-25.00 g / ml,it had a good linear relationship(r = 0.999 9),the minimum detectable concentration was 1.25 g / ml,a good solution stability and the relative standard deviation of 0.5%.Using the standard method,the sample concentration was 102.06%,102.35% and 102.00%,but the result was 101.59%,101.86% and 101.42% with the improved method.Conclusions: Comparing with the standard method,the improved method can reduce the amount of splitting,decrease the sample concentration,improve the detection accuracy,shorten the analysis time.It can be used for content determination of vitamin B12 tablet.
Objective: To improve the sample processing method of vitamin B12 tablets content determination.Methods: Take vitamin B12 55 pieces,make 1 ml solution contain about 12.5 g vitamin B12.Detect the absorbance by UV spectrophotometry with the wavelength of 361 nm.Results: When vitamin B12 content was in the range of 1.25-25.00 g / ml,it had a good linear relationship(r = 0.999 9),the minimum detectable concentration was 1.25 g / ml,a good solution stability and the relative standard deviation of 0.5%.Using the standard method,the sample concentration was 102.06%,102.35% and 102.00%,but the result was 101.59%,101.86% and 101.42% with the improved method.Conclusions: Comparing with the standard method,the improved method can reduce the amount of splitting,decrease the sample concentration,improve the detection accuracy,shorten the analysis time.It can be used for content determination of vitamin B12 tablet.
2013, 37(5): 604-607.
Abstract:
Objective: To provide basis for the monitoring and prevention of measles by detecting the genotype of wild-type measles strains and analyze the gene characteristics of epidemic measles virus from in Bengbu,Anhui.Methods: Fifteen sporadic cases clinically diagnosed as measles from 2010 to 2011 in Bengbu Anhui were selected in the study.The patients' urine samples were collected in the acute infectious period,the virus RNA was extracted,the nucleotide protein gene of carboxyl-terminal 515 bp nucleotide fragment of measles virus was amplified by RT-PCR,and gene phylogenetic tree was constructed by nucleotide sequencing and analysis of PCR.Results: Forteen wild-type measles strains were isolated from the urine samples of the 15 cases of measles;the gene homology of the 515 bp fragment of nucleoprotein(N) carboxy-terminal was compared between 3 wild-type measles strains and 8 reference strains in Genebank.The corresponding genetic distance of the nucleotide sequence to the published H1,H2 genotype reference strains in Hunan,CHN93-7,Beijing and CHN94 in Gene bank was 0.020 to 0.026 and 0.064 to 0.075 respectively;the distance to H1a reference strain China 93-2 was the shortest,which was 0.009 to 0.015;the 515 nucleotide homology of the N gene carboxy-terminal of the 3 measles strain were 97.8% to 98.9%;the corresponding nucleotide homology to the reference strains H1 CHN93-7,H1a China 93-2 and H1b China 94-7 were from 97.4% to 98.0%,98.5% to 99.1% and 96.5% to 97.1%,respectively.Conclusions: The dominant genotype of wild-type measles strains is H1a.
Objective: To provide basis for the monitoring and prevention of measles by detecting the genotype of wild-type measles strains and analyze the gene characteristics of epidemic measles virus from in Bengbu,Anhui.Methods: Fifteen sporadic cases clinically diagnosed as measles from 2010 to 2011 in Bengbu Anhui were selected in the study.The patients' urine samples were collected in the acute infectious period,the virus RNA was extracted,the nucleotide protein gene of carboxyl-terminal 515 bp nucleotide fragment of measles virus was amplified by RT-PCR,and gene phylogenetic tree was constructed by nucleotide sequencing and analysis of PCR.Results: Forteen wild-type measles strains were isolated from the urine samples of the 15 cases of measles;the gene homology of the 515 bp fragment of nucleoprotein(N) carboxy-terminal was compared between 3 wild-type measles strains and 8 reference strains in Genebank.The corresponding genetic distance of the nucleotide sequence to the published H1,H2 genotype reference strains in Hunan,CHN93-7,Beijing and CHN94 in Gene bank was 0.020 to 0.026 and 0.064 to 0.075 respectively;the distance to H1a reference strain China 93-2 was the shortest,which was 0.009 to 0.015;the 515 nucleotide homology of the N gene carboxy-terminal of the 3 measles strain were 97.8% to 98.9%;the corresponding nucleotide homology to the reference strains H1 CHN93-7,H1a China 93-2 and H1b China 94-7 were from 97.4% to 98.0%,98.5% to 99.1% and 96.5% to 97.1%,respectively.Conclusions: The dominant genotype of wild-type measles strains is H1a.
2013, 37(5): 607-609.
Abstract:
Objective: To explore the prevalence status and molecular features of astrovirus diarrhea in infants from Jilin and Lanzhou.Methods: The astrovirus expressions in 417 diarrhea specimens from Jinlin and 290 specimens from Lanzhou were detected by one-step PCR.Partial nucleotide fragments in ORF1b region of astrovirus genome were screened,which were somatotypedbg using partial ORF2 sequences.Results: Seventeen postive astrovirus cases in 707 diarrhea specimens,which included 7 cases from Jilin and 10 cases from Lanzhou were detected,the total postive rate was 2.4%.The postive ORF2 specimens in 12 cases were HAstV 1,which belonged to Lineage 1b cluster except 1 Lineage 1a cluster.The HAstV infection mainly distributed in infants less than 2 years,the main morbidity season in Jinlin and Lanzhou were Spring and Autumn,respectively.Conclusions: Astrovirus is the main pathogen of virus diarrhea in infants,HAstV 1 is common serotype,children less than two years old are high-risk group and main morbidity season is difference in different areas.
Objective: To explore the prevalence status and molecular features of astrovirus diarrhea in infants from Jilin and Lanzhou.Methods: The astrovirus expressions in 417 diarrhea specimens from Jinlin and 290 specimens from Lanzhou were detected by one-step PCR.Partial nucleotide fragments in ORF1b region of astrovirus genome were screened,which were somatotypedbg using partial ORF2 sequences.Results: Seventeen postive astrovirus cases in 707 diarrhea specimens,which included 7 cases from Jilin and 10 cases from Lanzhou were detected,the total postive rate was 2.4%.The postive ORF2 specimens in 12 cases were HAstV 1,which belonged to Lineage 1b cluster except 1 Lineage 1a cluster.The HAstV infection mainly distributed in infants less than 2 years,the main morbidity season in Jinlin and Lanzhou were Spring and Autumn,respectively.Conclusions: Astrovirus is the main pathogen of virus diarrhea in infants,HAstV 1 is common serotype,children less than two years old are high-risk group and main morbidity season is difference in different areas.
2013, 37(5): 611-613.
Abstract:
Objective: To investigate the changes of brain natriuretic peptide(BNP) level in patients with chronic renal failure(CRF) and analyze its correlation with cardiac function.Methods: Echocardiographic parameters,serum creatinine and BNP levels of 90 patients with CRF were determined in our hospital.The relationship between plasma BNP level and echocardiographic parameters(LVPW,IVS,EF) in different renal function(CKD) classification and NYHA functional class were compared and analyzed.Results: When glomerular filtration rate 60(ml.min-1.1.73 m-2),there was no statistical significance about plasma BNP level in hemodialysis,peritoneal dialysis and different CKD stages patients(P 0.05),but was significantly difference between patients in different NYHA groups(P 0.01),and with increased plasma BNP level,EF value was lower,IVS and LVPW values were higher(P 0.05).Conclusions: Worse cardiac function in patients with CRF,higher the plasma BNP content,which contribute to diagnosis and treatment monitoring for impaired cardiac function.
Objective: To investigate the changes of brain natriuretic peptide(BNP) level in patients with chronic renal failure(CRF) and analyze its correlation with cardiac function.Methods: Echocardiographic parameters,serum creatinine and BNP levels of 90 patients with CRF were determined in our hospital.The relationship between plasma BNP level and echocardiographic parameters(LVPW,IVS,EF) in different renal function(CKD) classification and NYHA functional class were compared and analyzed.Results: When glomerular filtration rate 60(ml.min-1.1.73 m-2),there was no statistical significance about plasma BNP level in hemodialysis,peritoneal dialysis and different CKD stages patients(P 0.05),but was significantly difference between patients in different NYHA groups(P 0.01),and with increased plasma BNP level,EF value was lower,IVS and LVPW values were higher(P 0.05).Conclusions: Worse cardiac function in patients with CRF,higher the plasma BNP content,which contribute to diagnosis and treatment monitoring for impaired cardiac function.
2013, 37(5): 614-616.
Abstract:
Objective: To discuss the influence of peer education on internet addiction in college students.Methods: Fifty-four 3-year college students of a university in Anhui province were chosen to be as the study subjects.Those who were selected to do the peer education were trained and thereafter they would do the peer education for other students.The morbidity of addiction trend,addiction rate,psychology health level,dealing measure scales before and after intervention were compared.Results: Before intervention,the addiction rate was 11.1% and the addiction trend morbidity was 14.8%,these both were decreased to 1.9% after intervention,which were shown significant statistical significances(P 0.01).After the intervention,the total scores of SCL-90,somatization,sensitivity of interpersonal relations,depression hostility,phobia anxiety paranoid idention and psychoticism are lower than they were before the intervention(P 0.05-P 0.01);the negative style decreased considerobly(P 0.01).Conclusions: The peer education can reduce the internet addiction of college students,increase the psychological health level and improve the negative dealing measures.
Objective: To discuss the influence of peer education on internet addiction in college students.Methods: Fifty-four 3-year college students of a university in Anhui province were chosen to be as the study subjects.Those who were selected to do the peer education were trained and thereafter they would do the peer education for other students.The morbidity of addiction trend,addiction rate,psychology health level,dealing measure scales before and after intervention were compared.Results: Before intervention,the addiction rate was 11.1% and the addiction trend morbidity was 14.8%,these both were decreased to 1.9% after intervention,which were shown significant statistical significances(P 0.01).After the intervention,the total scores of SCL-90,somatization,sensitivity of interpersonal relations,depression hostility,phobia anxiety paranoid idention and psychoticism are lower than they were before the intervention(P 0.05-P 0.01);the negative style decreased considerobly(P 0.01).Conclusions: The peer education can reduce the internet addiction of college students,increase the psychological health level and improve the negative dealing measures.
2013, 37(5): 617-619.
Abstract:
Objective: To explore the potential association of the professional thought with the human caring capacity of the nursing undergraduates so as to provide a reference for the enhancement of the human caring capacity in them.Methods: Eight hundred nursing undergraduates of grade 2-4 from two nursing schools were investigated by Caring ability Inventory and professional thinking questionnaires.Results: The nursing undergraduates who had more stable professional thought and stronger interest in professional and humanity courses possessed better human caring capacities(P 0.01).Conclusions: The professional thought is potentially related with the human caring capacity of the nursing undergraduates.
Objective: To explore the potential association of the professional thought with the human caring capacity of the nursing undergraduates so as to provide a reference for the enhancement of the human caring capacity in them.Methods: Eight hundred nursing undergraduates of grade 2-4 from two nursing schools were investigated by Caring ability Inventory and professional thinking questionnaires.Results: The nursing undergraduates who had more stable professional thought and stronger interest in professional and humanity courses possessed better human caring capacities(P 0.01).Conclusions: The professional thought is potentially related with the human caring capacity of the nursing undergraduates.
2013, 37(5): 620-622.
Abstract:
Objective: To investigate the mental health of patients with rheumatic diseases,explore the effects of psychotherapy on them.Methods: SCL-90 questionnaires were released to 80 patients in the rheumatism department and 66 valid questionnaires were retrieved;the results were compared with that of the normal.The 66 patients were randomly divided into study group and control group.The patients in the study group received psychotherapy and pharmacotherapy;the patients in the control group received pharmacotherapy only.Results: According to SCL-90,the score of the positive symptom,interpersonal relation and paranoia had no significant difference between patients with rheumatism and the control(P 0.05),but the other scores were significantly different(P 0.01).After 6 weeks of treatment,the total value of SCL-90,total split,somatization,depression,anxiety and other factor points in the study group were significantly higher than those in the control group(P 0.01).Conclusions: Patients with rheumatism often present some degree of mental psychotic symptoms,so psychotherapy should not be ignored.Psychotherapy can improve the mental health status and the overall curative effect of patients with rheumatism.
Objective: To investigate the mental health of patients with rheumatic diseases,explore the effects of psychotherapy on them.Methods: SCL-90 questionnaires were released to 80 patients in the rheumatism department and 66 valid questionnaires were retrieved;the results were compared with that of the normal.The 66 patients were randomly divided into study group and control group.The patients in the study group received psychotherapy and pharmacotherapy;the patients in the control group received pharmacotherapy only.Results: According to SCL-90,the score of the positive symptom,interpersonal relation and paranoia had no significant difference between patients with rheumatism and the control(P 0.05),but the other scores were significantly different(P 0.01).After 6 weeks of treatment,the total value of SCL-90,total split,somatization,depression,anxiety and other factor points in the study group were significantly higher than those in the control group(P 0.01).Conclusions: Patients with rheumatism often present some degree of mental psychotic symptoms,so psychotherapy should not be ignored.Psychotherapy can improve the mental health status and the overall curative effect of patients with rheumatism.
2013, 37(5): 623-626.
Abstract:
Objective: To investigate the effects of simulated family nursing on patients with Alzheimer disease and their caregivers.Methods: Eighty-two patients with Alzheimer disease were evenly divided into study group and control group.The study group received simulated family nursing mode and the control group routine nursing.The mini-mental state(MMSE) and the activities of daily living(ADL) of the two groups were evaluated before intervention,6 months and 12 months after intervention.The caregivers were investigated by the Symptom Checklist and trait coping style questionnaire.Results: The difference of the total MMSE score and ADL score in the 0th and 6th month was not statistically significant between the study group and the control group(P 0.05);the difference was statistically significant in the 12th month(P 0.05).The scores of the caregivers in the study group and the control group was significantly different in the 12th month(P 0.05);the scores were significantly different between the two groups(P 0.05 and P 0.01).The somatization,depression,anxiety and negative response of the caregivers of patients with Alzheimer disease in the study group were negatively correlated with MMSE scores,and positively correlated with ADL scores(P 0.05).Conclusions: The simulated family nursing could reduce the depression,anxiety and negative coping style of the caregivers of the Alzheimer patients and delay the progression of the disease.
Objective: To investigate the effects of simulated family nursing on patients with Alzheimer disease and their caregivers.Methods: Eighty-two patients with Alzheimer disease were evenly divided into study group and control group.The study group received simulated family nursing mode and the control group routine nursing.The mini-mental state(MMSE) and the activities of daily living(ADL) of the two groups were evaluated before intervention,6 months and 12 months after intervention.The caregivers were investigated by the Symptom Checklist and trait coping style questionnaire.Results: The difference of the total MMSE score and ADL score in the 0th and 6th month was not statistically significant between the study group and the control group(P 0.05);the difference was statistically significant in the 12th month(P 0.05).The scores of the caregivers in the study group and the control group was significantly different in the 12th month(P 0.05);the scores were significantly different between the two groups(P 0.05 and P 0.01).The somatization,depression,anxiety and negative response of the caregivers of patients with Alzheimer disease in the study group were negatively correlated with MMSE scores,and positively correlated with ADL scores(P 0.05).Conclusions: The simulated family nursing could reduce the depression,anxiety and negative coping style of the caregivers of the Alzheimer patients and delay the progression of the disease.
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