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2013 Vol. 38, No. 7
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2013, 37(7): 777-780.
Abstract:
Objective:To clonePlasmodium vivaxaldolase(PvALD) gene,express and identify the recombinant PvALD protein in vitro.Methods:PCR was performed to amplify PvALD gene from blood sample of P.vivax infected patient.pET32c-PvALD recombinant plasmid was constructed and transformed intoE.colihost BL21(DE3+),IPTG was used to induce the recombinant protein PvALD fused with His tag.Induction time,IPTG concentration and media types were optimized for expression of PvALD in E.coli.Then recombinant protein was purified by His-NTA affinity chromatography and identified by SDS-PAGE and Western blot.Results:The PvALD PCR product was about 1.1 kb,meeting the expectation of predicted fragment size.The recombinant pET32c-PvALD plasmid was verified by sequencing that the insertion was 100% homology with GenBank reference sequence.Optimized condition for recombinant PvALD was at 1 mmol/L IPTG concentration,6 h and in LB medium.SDS-PAGE result showed that recombinant PvALD was about 60 kD.Western blot result showed that recombinant PvALD could be recognized by serum from vivax-malaria patient,but not by serum from falciparum-malaria patient.Conclusions:The PvALD gene is successfully cloned,and recombinant PvALD protein is expressed,which offers basis for diagnosis rapidly.
Objective:To clonePlasmodium vivaxaldolase(PvALD) gene,express and identify the recombinant PvALD protein in vitro.Methods:PCR was performed to amplify PvALD gene from blood sample of P.vivax infected patient.pET32c-PvALD recombinant plasmid was constructed and transformed intoE.colihost BL21(DE3+),IPTG was used to induce the recombinant protein PvALD fused with His tag.Induction time,IPTG concentration and media types were optimized for expression of PvALD in E.coli.Then recombinant protein was purified by His-NTA affinity chromatography and identified by SDS-PAGE and Western blot.Results:The PvALD PCR product was about 1.1 kb,meeting the expectation of predicted fragment size.The recombinant pET32c-PvALD plasmid was verified by sequencing that the insertion was 100% homology with GenBank reference sequence.Optimized condition for recombinant PvALD was at 1 mmol/L IPTG concentration,6 h and in LB medium.SDS-PAGE result showed that recombinant PvALD was about 60 kD.Western blot result showed that recombinant PvALD could be recognized by serum from vivax-malaria patient,but not by serum from falciparum-malaria patient.Conclusions:The PvALD gene is successfully cloned,and recombinant PvALD protein is expressed,which offers basis for diagnosis rapidly.
2013, 37(7): 781-783,786.
Abstract:
Objective: To investigate the correlations between allele polymorphism of HLA-DQB1 in the short arm of chromosome 6 and cervical cancer from Guangdong Han nationality family.Methods:The genotypes of HLA-DQB1 from 75 cervical cancer families were detected by polymerase chain reaction of sequencing based typing,which were analysed by family-based association test(FBAT).Results:FBAT showed that DQB1* 030302(P0.01) and DQB1* 0602(P0.05) might increase the onset risk of cervical cancer.Conclusions:The partial alleles in typeⅡ HLA gene may be the susceptible gene of cervical cancer in Guangdong Han population.The DQB1* 030302 and DQB1*0602 are associated with the pathogenesis of cervical cancer.
Objective: To investigate the correlations between allele polymorphism of HLA-DQB1 in the short arm of chromosome 6 and cervical cancer from Guangdong Han nationality family.Methods:The genotypes of HLA-DQB1 from 75 cervical cancer families were detected by polymerase chain reaction of sequencing based typing,which were analysed by family-based association test(FBAT).Results:FBAT showed that DQB1* 030302(P0.01) and DQB1* 0602(P0.05) might increase the onset risk of cervical cancer.Conclusions:The partial alleles in typeⅡ HLA gene may be the susceptible gene of cervical cancer in Guangdong Han population.The DQB1* 030302 and DQB1*0602 are associated with the pathogenesis of cervical cancer.
2013, 37(7): 784-786.
Abstract:
Objective: To explore the correlation between gastric epithelial cell apoptosis induced byHelicobacter pylori(Hp) and nitric oxide(NO) in rats.Methods:Sixty wistar rats were randomly divided into the control group,Hp infection group and Hp eradication group(20 rats each group).The rats in the control group were fed as normal.The chronic gastritis model rats in HP infection group were established then the rats were infected with Hp according to chen's methods.The rats in Hp eradication group were treated with quadruple chemotherapy after Hp infection.The gastric epithelial apoptosis of rats in all groups were determined by nick terminal lable technique(TUNEL),the NO levels in serum of 3 groups were determined by nitrate reductase method.Results:The apoptotic index in gastric endothelial cell and levels of NO in serum in Hp infection group were significantly higher than those in control group (P0.01).Compared with the Hp infection group,the apoptotic index in gastric endothelial cell and levels of NO in serum in Hp eradication group were significantly reduced(P0.01).There were positively correlations between the apoptotic index and NO levels in Hp infection group and Hp eradication group (P0.05).Conclusions:Hp can induce the apoptosis of gastric endothelial cell.Promoting the NO generation may be one of inducing cell apoptosis mechanisms.
Objective: To explore the correlation between gastric epithelial cell apoptosis induced byHelicobacter pylori(Hp) and nitric oxide(NO) in rats.Methods:Sixty wistar rats were randomly divided into the control group,Hp infection group and Hp eradication group(20 rats each group).The rats in the control group were fed as normal.The chronic gastritis model rats in HP infection group were established then the rats were infected with Hp according to chen's methods.The rats in Hp eradication group were treated with quadruple chemotherapy after Hp infection.The gastric epithelial apoptosis of rats in all groups were determined by nick terminal lable technique(TUNEL),the NO levels in serum of 3 groups were determined by nitrate reductase method.Results:The apoptotic index in gastric endothelial cell and levels of NO in serum in Hp infection group were significantly higher than those in control group (P0.01).Compared with the Hp infection group,the apoptotic index in gastric endothelial cell and levels of NO in serum in Hp eradication group were significantly reduced(P0.01).There were positively correlations between the apoptotic index and NO levels in Hp infection group and Hp eradication group (P0.05).Conclusions:Hp can induce the apoptosis of gastric endothelial cell.Promoting the NO generation may be one of inducing cell apoptosis mechanisms.
2013, 37(7): 787-789.
Abstract:
Objective: To observe the anatomical features of posterior arch of atlas in adult and provide the anatomical basis for its operation.Methods:The bony structures and vertebral artery groove of posterior arch of atlas in 80 adult dry atlas specimens were measured.Results:The inside and outside radius,height and thickness of posterior arch of atlas were(21.75 2.59) mm,(29.85 2.27) mm,(7.49 2.75) mm and(7.56 2.17) mm,respectively.The radians of medial and lateral margin of posterior arch of atlas were(83.4 4.4) and(75.2 4.2) degrees.The length,width,height and inclination angle of vertebral artery groove were(9.86 2.41),(5.67 1.54) and(1.79 0.24) mm and(16.8 2.71) degrees,respectively.The vertical axis angle,transverse foramen angle and lateral mass angle were (18.1 2.4) degrees,(20.7 2.5) degrees and(11.4 1.8) degrees.Conclusions:The anatomical data of bony structures and vertebral artery groove of posterior arch of atlas have certain guiding significance in the treatment of atlas fracture with screw fixation,which can avoid to damage the spinal cord and vertebral artery.
Objective: To observe the anatomical features of posterior arch of atlas in adult and provide the anatomical basis for its operation.Methods:The bony structures and vertebral artery groove of posterior arch of atlas in 80 adult dry atlas specimens were measured.Results:The inside and outside radius,height and thickness of posterior arch of atlas were(21.75 2.59) mm,(29.85 2.27) mm,(7.49 2.75) mm and(7.56 2.17) mm,respectively.The radians of medial and lateral margin of posterior arch of atlas were(83.4 4.4) and(75.2 4.2) degrees.The length,width,height and inclination angle of vertebral artery groove were(9.86 2.41),(5.67 1.54) and(1.79 0.24) mm and(16.8 2.71) degrees,respectively.The vertical axis angle,transverse foramen angle and lateral mass angle were (18.1 2.4) degrees,(20.7 2.5) degrees and(11.4 1.8) degrees.Conclusions:The anatomical data of bony structures and vertebral artery groove of posterior arch of atlas have certain guiding significance in the treatment of atlas fracture with screw fixation,which can avoid to damage the spinal cord and vertebral artery.
2013, 37(7): 789-791.
Abstract:
Objective: To explore the effects of tetraiodothyronine(T4) injecting into late-pregnant rabbit on pups growth.Methods:Ten rabbits which pregnant for 16 days were prepared and divided into two groups with equal number,of which test group and control group,0.3 mg T4 were injected intramuscular to pregnant rabbits of test group and 2ml 0.9% NaCl were injected to pregnant rabbits of control group respective.To observe the change level of hormone,estradiol (E2) of adult pregnant rabbit and change level of thyroxine,insulin and body mass of new born rabbit of two groups.Results:The levels of pregnancy rabbit plasma E2,T3 and T4 of test group were higher than the control group(P0.05 - P0.01).T3,T4 of 1 - 5 weeks after birth pups levels of test group were lower than the control group(P0.05 - P0.01).While in the 1,4,6 week,insulin levels were higher than the control group(P0.05 - P0.01),the test group treated pregnant rabbits T4 pups 1 - 6 weeks physique increase in weight were higher (P0.05 -P0.01).Conclusions:Late pregnancy rabbit with T4 treatment can improve new-born rabbits plasma insulin levels and increase the growth rate of them.
Objective: To explore the effects of tetraiodothyronine(T4) injecting into late-pregnant rabbit on pups growth.Methods:Ten rabbits which pregnant for 16 days were prepared and divided into two groups with equal number,of which test group and control group,0.3 mg T4 were injected intramuscular to pregnant rabbits of test group and 2ml 0.9% NaCl were injected to pregnant rabbits of control group respective.To observe the change level of hormone,estradiol (E2) of adult pregnant rabbit and change level of thyroxine,insulin and body mass of new born rabbit of two groups.Results:The levels of pregnancy rabbit plasma E2,T3 and T4 of test group were higher than the control group(P0.05 - P0.01).T3,T4 of 1 - 5 weeks after birth pups levels of test group were lower than the control group(P0.05 - P0.01).While in the 1,4,6 week,insulin levels were higher than the control group(P0.05 - P0.01),the test group treated pregnant rabbits T4 pups 1 - 6 weeks physique increase in weight were higher (P0.05 -P0.01).Conclusions:Late pregnancy rabbit with T4 treatment can improve new-born rabbits plasma insulin levels and increase the growth rate of them.
2013, 37(7): 792-794.
Abstract:
Objective: To explore the effects of octreotide(OCT) on the growth cycle of hormone-resiotant human prostate cancer cell.Methods:PC-3 cell line(human prostate cancer cell) was treated with gradient concentration of OCT,the growth curve of PC-3 cells was observed,and the growth cycle of PC-3 cell was detected by flow cytometry.Results:Concentration-dependent growth inhibition of octreotide was detected in the PC-3 cell line(P0.05 to P0.01).The growth cycle of PC-3 cell arrested in G0 / G1 phase after treatment with OCT.Conclusions:Octreotide can inhibit the growth of prostate cancer cell line,which provide a new method for treating hormone refractory prostate cancer.
Objective: To explore the effects of octreotide(OCT) on the growth cycle of hormone-resiotant human prostate cancer cell.Methods:PC-3 cell line(human prostate cancer cell) was treated with gradient concentration of OCT,the growth curve of PC-3 cells was observed,and the growth cycle of PC-3 cell was detected by flow cytometry.Results:Concentration-dependent growth inhibition of octreotide was detected in the PC-3 cell line(P0.05 to P0.01).The growth cycle of PC-3 cell arrested in G0 / G1 phase after treatment with OCT.Conclusions:Octreotide can inhibit the growth of prostate cancer cell line,which provide a new method for treating hormone refractory prostate cancer.
2013, 37(7): 794-796.
Abstract:
Objective: To investigate the expression level of Wilms'tumor 1(WT1) gene in bone marrow of acute leukemia(AL) patients.Methods:The copy numbers of WT1 and reference gene in BM of 100 patients with AL were measured by real-time quantitative polymerase chain reaction (RQ-PCR).The gene level was determined by the ratio of the copy numbers of WT1 and reference gene.Results:The expression levels of WT1 in the newly diagnosed and relapsed AL patients were significantly higher than that in the complete remission(CR) AL patients(P0.01).In newly diagnosed AL patients,the WT1 expression difference in different subtype of AL was statistical significance(P0.01),the WT1 expression was the lowest in acute lymphocytic leukemia and the highest in acute promyelocytic leukemia.Three patients were followed up,the WT1 gene expression was low in the remission period,and increased after relapse.Conclusions:WT1 expression level in AL patients can be a marker for detecting minimal residual disease and evaluating therapy efficacy.
Objective: To investigate the expression level of Wilms'tumor 1(WT1) gene in bone marrow of acute leukemia(AL) patients.Methods:The copy numbers of WT1 and reference gene in BM of 100 patients with AL were measured by real-time quantitative polymerase chain reaction (RQ-PCR).The gene level was determined by the ratio of the copy numbers of WT1 and reference gene.Results:The expression levels of WT1 in the newly diagnosed and relapsed AL patients were significantly higher than that in the complete remission(CR) AL patients(P0.01).In newly diagnosed AL patients,the WT1 expression difference in different subtype of AL was statistical significance(P0.01),the WT1 expression was the lowest in acute lymphocytic leukemia and the highest in acute promyelocytic leukemia.Three patients were followed up,the WT1 gene expression was low in the remission period,and increased after relapse.Conclusions:WT1 expression level in AL patients can be a marker for detecting minimal residual disease and evaluating therapy efficacy.
2013, 37(7): 797-789,802.
Abstract:
Objective: To explore the expression and clinical significance of murine double minute 2(Mdm2) and phospho-serine/ threonine protein kinase(pAkt) in hepatocellular carcinoma(HCC).Methods:The protein levels of Mdm2 and pAkt were detected by EliVision immunohistochemistry in 70 HCC tissue samples and 40 tissues adjacent to carcinoma correlation between their expressions and clinicopathological features was analyzed.Results:The expression postive rate of Mdm2 in HCC tissue(34.3%) was significantly higher than that in tissues adjacent to carcinoma(P0.01),its expression in tumor size more than 5 cm or lymphnode metastasis tissue significantly increased(P0.05).The expression postive rate of pAkt in HCC tissue(37.1%) was significantly higher than that in tissues adjacent to carcinoma(P0.01),its expression differences in different tumor size,pathologic grade,TNM stage and lymphnode metastasis tissue were statistical significance(P0.05).The Mdm2 expression was positively related with pAkt expression in HCC tissue(r's= 0.441,P0.01).Conclusions:The expressions of Mdm2 and pAkt may be associated with the progression of HCC,which can serve as the index for evaluating the prognosis of HCC.
Objective: To explore the expression and clinical significance of murine double minute 2(Mdm2) and phospho-serine/ threonine protein kinase(pAkt) in hepatocellular carcinoma(HCC).Methods:The protein levels of Mdm2 and pAkt were detected by EliVision immunohistochemistry in 70 HCC tissue samples and 40 tissues adjacent to carcinoma correlation between their expressions and clinicopathological features was analyzed.Results:The expression postive rate of Mdm2 in HCC tissue(34.3%) was significantly higher than that in tissues adjacent to carcinoma(P0.01),its expression in tumor size more than 5 cm or lymphnode metastasis tissue significantly increased(P0.05).The expression postive rate of pAkt in HCC tissue(37.1%) was significantly higher than that in tissues adjacent to carcinoma(P0.01),its expression differences in different tumor size,pathologic grade,TNM stage and lymphnode metastasis tissue were statistical significance(P0.05).The Mdm2 expression was positively related with pAkt expression in HCC tissue(r's= 0.441,P0.01).Conclusions:The expressions of Mdm2 and pAkt may be associated with the progression of HCC,which can serve as the index for evaluating the prognosis of HCC.
2013, 37(7): 800-802.
Abstract:
Objective: To discuss the diagnosis and surgical treatment of leukemia complicated with invasive pulmonary fungal infection(IPFI).Methods:Eleven cases with leukemia complicated with IPFI were treated with operation,which included pulmonary wedge resection in 5 cases and pulmonary lobectomy in 6 cases.Al2 patients were treated with antifungal drugs before and after operation,and followed up after operation.Results:No case died during perioperative period,aspergillus infection in 7 cases,mucor infection in 2 case,cryptococcus infection in 1 case and mixed infection in 2 case were confirmed by pathologic examination.Three cases died of leukemia relapse and no fungus recurrence case was found.Conclusions:IPFI treated with surgical resection can reduce the fungal relapse during chemotherapy period of leukemia patients.
Objective: To discuss the diagnosis and surgical treatment of leukemia complicated with invasive pulmonary fungal infection(IPFI).Methods:Eleven cases with leukemia complicated with IPFI were treated with operation,which included pulmonary wedge resection in 5 cases and pulmonary lobectomy in 6 cases.Al2 patients were treated with antifungal drugs before and after operation,and followed up after operation.Results:No case died during perioperative period,aspergillus infection in 7 cases,mucor infection in 2 case,cryptococcus infection in 1 case and mixed infection in 2 case were confirmed by pathologic examination.Three cases died of leukemia relapse and no fungus recurrence case was found.Conclusions:IPFI treated with surgical resection can reduce the fungal relapse during chemotherapy period of leukemia patients.
2013, 37(7): 803-805,808.
Abstract:
Objective: To investigate the correlation of serum retinol-binding protein 4(RBP4) and diabetic retinopathy(DR) of elderly type 2 diabetic patients.Methods:Two hundred and ten patients,who were 60 years or elder,with type 2 diabetes were investigated,102 cases without DR and 108 cases with DR were divided into the control and observation group(namely T2DM and DR group),respectively.According to the degree of fundus lesions,DR group were subdivided into non-proliferative stage group (NPDR group,69 cases) and proliferative stage group(PDR group,33 cases).The clinical parameters and biochemical indicators of T2DM ＆ DR group and NPDR ＆ PDR group were compared.The independent risk factors of DR were analysed by logistic regression.Results:Compared with the T2DM and NPDR group,the disease course,the levels of fasting blood glucose,HbA1c and RBP4 of DR group prolonged and increased significantly(P0.01 and P0.05).The results of logistic regression showed that the disease course,the levels of HbA1c and RBP4 were independent risk factors of DR(P0.01).Conclusions:The disease course of diabetes,HbA1c and RBP are three independent risk factors of DR.
Objective: To investigate the correlation of serum retinol-binding protein 4(RBP4) and diabetic retinopathy(DR) of elderly type 2 diabetic patients.Methods:Two hundred and ten patients,who were 60 years or elder,with type 2 diabetes were investigated,102 cases without DR and 108 cases with DR were divided into the control and observation group(namely T2DM and DR group),respectively.According to the degree of fundus lesions,DR group were subdivided into non-proliferative stage group (NPDR group,69 cases) and proliferative stage group(PDR group,33 cases).The clinical parameters and biochemical indicators of T2DM ＆ DR group and NPDR ＆ PDR group were compared.The independent risk factors of DR were analysed by logistic regression.Results:Compared with the T2DM and NPDR group,the disease course,the levels of fasting blood glucose,HbA1c and RBP4 of DR group prolonged and increased significantly(P0.01 and P0.05).The results of logistic regression showed that the disease course,the levels of HbA1c and RBP4 were independent risk factors of DR(P0.01).Conclusions:The disease course of diabetes,HbA1c and RBP are three independent risk factors of DR.
2013, 37(7): 806-808.
Abstract:
Objective: To investigate the pathogeny and relative factors of acute non-variceal upper gastrointestinal hemorrhage in aged people.Methods:The clinical data of 104 aged people with acute nonvariceal upper gastrointestinal hemorrhage diagnosed by gastroscope (observation group) were retrospectively analyzed,104 young and middle-aged people with acute nonvariceal upper gastrointestinal hemorrhage diagnosed by gastroscope were set as control group.The causes of disease,uncontrolled hemorrhagic incidence of peripheral circulatory failure,stay days,incentive,complications,the rebleeding rate(during hospital stay) and mortality of two groups were analyzed.Results:The peptic ulcer was the main causes of disease in two groups,their causes composition was not statistical significance(P0.05).Helicobacter pylori(Hp) infection and the application of non-steroidal anti-inflammatory drug were the main incentive in observation group,Hp infection and drinking were the main incentive in control group.Uncontrolled hemorrhagic incidence of peripheral circulatory failure,stay days,complications,the rebleeding rate and mortality of observtion group were higher than those in control group(P0.05 to P0.01).Conclusions:Clearing pathogeny and inducement as early as possible and taking reasonable treatment during the period of acute non-variceal upper gastrointestinal hemorrhage can reduce the mortality and rebleeding rate of aged people.Strengthening health education can reduce the incidence of upper gastrointestinal hemorrhage.
Objective: To investigate the pathogeny and relative factors of acute non-variceal upper gastrointestinal hemorrhage in aged people.Methods:The clinical data of 104 aged people with acute nonvariceal upper gastrointestinal hemorrhage diagnosed by gastroscope (observation group) were retrospectively analyzed,104 young and middle-aged people with acute nonvariceal upper gastrointestinal hemorrhage diagnosed by gastroscope were set as control group.The causes of disease,uncontrolled hemorrhagic incidence of peripheral circulatory failure,stay days,incentive,complications,the rebleeding rate(during hospital stay) and mortality of two groups were analyzed.Results:The peptic ulcer was the main causes of disease in two groups,their causes composition was not statistical significance(P0.05).Helicobacter pylori(Hp) infection and the application of non-steroidal anti-inflammatory drug were the main incentive in observation group,Hp infection and drinking were the main incentive in control group.Uncontrolled hemorrhagic incidence of peripheral circulatory failure,stay days,complications,the rebleeding rate and mortality of observtion group were higher than those in control group(P0.05 to P0.01).Conclusions:Clearing pathogeny and inducement as early as possible and taking reasonable treatment during the period of acute non-variceal upper gastrointestinal hemorrhage can reduce the mortality and rebleeding rate of aged people.Strengthening health education can reduce the incidence of upper gastrointestinal hemorrhage.
2013, 37(7): 809-812,815.
Abstract:
Objective: To investigate the expression of Ezrin and its significance in breast cancer.Methods:The Ezrin expressions in breast cancer tissue of 90 cases,adenosis tissue of 10 cases and breast intraductal papillary tumor tissue of 10 cases were detected by SP immunohistochemistry.Results:The strong positive expression rates of Ezrin in breast cancer tissue,adenosis tissue and breast intraductal papillary tumor tissue were 58.9%,10.0% and 20.0%,respectively,the differences of which were statistical significant(P 0.01).The expression level of Ezrin in cases with lymph node metastasis was higher than in whose without lymph node metastasis(P 0.01),and its expression differences in tumor size,TNM staging and age were not statistically significant (P0.05).The most expression position of Ezrin in breast cancer was in the cytoplasm(62.2%),part expression was in the membrane(22.0%) and cell membrane top(15.8%).The most expression position of Ezrin in adenosis tissue and breast intraductal papillary tumor tissue was in cell membrane top(7 /9 and 6 /9).The Ezrin expression differences of three groups were statistical significance(P0.01).The Ezrin expression in cell membrane top of breast cancer was related to the lymph node metastasis,differentiation stage and hormone receptor expression(P0.05 to P0.01).The Ezrin expression of in cytoplasm was related to the lymph node metastasis,high differentiation stage and hormone receptor negative expression(P0.05 to P0.01).The differences of Ezrin expression in membrane and HER2 expression were statistical significance (P0.05).Conclusions:The heightening expression and the expression position change of Ezrin play a regulating role on the occurrence,development and metastasis of breast cancer,which may be an important biological indicator in diagnosing the metastasis and prognosis of breast cancer.
Objective: To investigate the expression of Ezrin and its significance in breast cancer.Methods:The Ezrin expressions in breast cancer tissue of 90 cases,adenosis tissue of 10 cases and breast intraductal papillary tumor tissue of 10 cases were detected by SP immunohistochemistry.Results:The strong positive expression rates of Ezrin in breast cancer tissue,adenosis tissue and breast intraductal papillary tumor tissue were 58.9%,10.0% and 20.0%,respectively,the differences of which were statistical significant(P 0.01).The expression level of Ezrin in cases with lymph node metastasis was higher than in whose without lymph node metastasis(P 0.01),and its expression differences in tumor size,TNM staging and age were not statistically significant (P0.05).The most expression position of Ezrin in breast cancer was in the cytoplasm(62.2%),part expression was in the membrane(22.0%) and cell membrane top(15.8%).The most expression position of Ezrin in adenosis tissue and breast intraductal papillary tumor tissue was in cell membrane top(7 /9 and 6 /9).The Ezrin expression differences of three groups were statistical significance(P0.01).The Ezrin expression in cell membrane top of breast cancer was related to the lymph node metastasis,differentiation stage and hormone receptor expression(P0.05 to P0.01).The Ezrin expression of in cytoplasm was related to the lymph node metastasis,high differentiation stage and hormone receptor negative expression(P0.05 to P0.01).The differences of Ezrin expression in membrane and HER2 expression were statistical significance (P0.05).Conclusions:The heightening expression and the expression position change of Ezrin play a regulating role on the occurrence,development and metastasis of breast cancer,which may be an important biological indicator in diagnosing the metastasis and prognosis of breast cancer.
2013, 37(7): 813-815.
Abstract:
Objective: To compare the clinical effects of percutaneous minimally invasive plate fixation and conventional plate fixation in the treatment of tibia fracture.Methods:Eighty patients with tibia fractures were randomly divided into the observation group and control group(40 cases each group).The observation group and control group were treated with percutaneous minimally invasive plate fixation and conventional plate fixation,respectively.The blood loss,fracture healing,incidence of fracture nonunion or delayed union and linear and positional alignment between two groups were compared.Results:The callus formation,fracture healing and walking regained in observation group were significantly shorter than those in control group(P0.01),the blood loss in observation group was significantly less than that in control group (P0.01).the excellent rate of therapeutic effect in observation group (100.0%) was significantly higher than that in control group(75.0%) (P0.05).The differences of postoperative complications between two groups statistical significance(P0.05).Conclusions:Percutaneous minimally invasive plate fixation for treating tibial fractures meets with the principles of biological osteosynthesis,which is good for bone healing and an effective method.
Objective: To compare the clinical effects of percutaneous minimally invasive plate fixation and conventional plate fixation in the treatment of tibia fracture.Methods:Eighty patients with tibia fractures were randomly divided into the observation group and control group(40 cases each group).The observation group and control group were treated with percutaneous minimally invasive plate fixation and conventional plate fixation,respectively.The blood loss,fracture healing,incidence of fracture nonunion or delayed union and linear and positional alignment between two groups were compared.Results:The callus formation,fracture healing and walking regained in observation group were significantly shorter than those in control group(P0.01),the blood loss in observation group was significantly less than that in control group (P0.01).the excellent rate of therapeutic effect in observation group (100.0%) was significantly higher than that in control group(75.0%) (P0.05).The differences of postoperative complications between two groups statistical significance(P0.05).Conclusions:Percutaneous minimally invasive plate fixation for treating tibial fractures meets with the principles of biological osteosynthesis,which is good for bone healing and an effective method.
2013, 37(7): 816-817,820.
Abstract:
Objective: To explore the clinical effects of cast metal post with porcelain-fused-to -metal(PFM) crown in the restoration of maxillary anterior teeth lip deformity.Methods:Twenty patients with maxillary anterior teeth (62 teeth) lip deformity,who was unwilling to accept orthodontic treatment were treated with conventional root canal therapy and PFM crown restoration after cast metal post redirection.Results:Except for 1 case was lost to follow-up,other patients were followed up for 2 to 3.5 years.The root fracture in 2 teeth,crown fall off in 1 tooth and gingival edge discoloration in 2 teeth were found.Conclusions:PFM crown restoration after cast metal post redirection is an effective treatment for patients with maxillary anterior teeth lip deformity unwilling to accept orthodontic treatment.
Objective: To explore the clinical effects of cast metal post with porcelain-fused-to -metal(PFM) crown in the restoration of maxillary anterior teeth lip deformity.Methods:Twenty patients with maxillary anterior teeth (62 teeth) lip deformity,who was unwilling to accept orthodontic treatment were treated with conventional root canal therapy and PFM crown restoration after cast metal post redirection.Results:Except for 1 case was lost to follow-up,other patients were followed up for 2 to 3.5 years.The root fracture in 2 teeth,crown fall off in 1 tooth and gingival edge discoloration in 2 teeth were found.Conclusions:PFM crown restoration after cast metal post redirection is an effective treatment for patients with maxillary anterior teeth lip deformity unwilling to accept orthodontic treatment.
2013, 37(7): 818-820.
Abstract:
Objective: To investigate the effects of cognitive behavioral therapy on the sleep disorder of the patients with ankylosing spondylitis(AS).Methods:Eighty-eight patients with AS complicated with sleep disorder were randomly divided into control and observation group(44 cases each group) according to admission time.The control group were treated with basic therapy,the observation group were treated with cognitive behavioral therapy based on basic therapy.The sleep qualities in two groups were observed.Results:After treatment,the score of Pittsburgh sleep qualily index factor and total score of the observation group were significantly lower than those before treatment and in control group(P0.01).Conclusions:Cognitive behavioral therapy can effectively improve the sleep quality of AS patients.
Objective: To investigate the effects of cognitive behavioral therapy on the sleep disorder of the patients with ankylosing spondylitis(AS).Methods:Eighty-eight patients with AS complicated with sleep disorder were randomly divided into control and observation group(44 cases each group) according to admission time.The control group were treated with basic therapy,the observation group were treated with cognitive behavioral therapy based on basic therapy.The sleep qualities in two groups were observed.Results:After treatment,the score of Pittsburgh sleep qualily index factor and total score of the observation group were significantly lower than those before treatment and in control group(P0.01).Conclusions:Cognitive behavioral therapy can effectively improve the sleep quality of AS patients.
2013, 37(7): 821-823.
Abstract:
Objective: To explore the expression of Stathmin protein in human breast cancer and evaluate the relationship between the expression of Stathmin and clinicopathological characteristics of breast cancer.Methods:The expression levels of Stathmin protein in 87 cases of breast cancer,20 cases of breast benign lesions and 20 cases normal breast tissue were investigated by immunohistochemical method.The relationships between the expression of Stathmin and patients'age,tumor size,histological grade,clinical stage and lymph node metastasis of breast cancer were analyzed.Results:The positive expression rates of Stathmin in breast cancer,breast benign lesions and normal breast tissue were 83.9%,30.0% and 25.0%,respectively,the Stathmin expression in breast cancer was significantly higher than that in breast benign lesions and normal breast tissue(P0.01).The differences of Stathmin expression in different clinical stage and lymph node metastasis had statistical significance(P0.05),the differences of Stathmin expression in different patient's age,tumor size and histological grade had no statistical significance (P0.05).Conclusions:Stathmin is overexpressed in breast cancer,which may play a certain role in its genesis and development.Stathmin can serve as a potential marker in the diagnosis and prognosis of breast cancer.
Objective: To explore the expression of Stathmin protein in human breast cancer and evaluate the relationship between the expression of Stathmin and clinicopathological characteristics of breast cancer.Methods:The expression levels of Stathmin protein in 87 cases of breast cancer,20 cases of breast benign lesions and 20 cases normal breast tissue were investigated by immunohistochemical method.The relationships between the expression of Stathmin and patients'age,tumor size,histological grade,clinical stage and lymph node metastasis of breast cancer were analyzed.Results:The positive expression rates of Stathmin in breast cancer,breast benign lesions and normal breast tissue were 83.9%,30.0% and 25.0%,respectively,the Stathmin expression in breast cancer was significantly higher than that in breast benign lesions and normal breast tissue(P0.01).The differences of Stathmin expression in different clinical stage and lymph node metastasis had statistical significance(P0.05),the differences of Stathmin expression in different patient's age,tumor size and histological grade had no statistical significance (P0.05).Conclusions:Stathmin is overexpressed in breast cancer,which may play a certain role in its genesis and development.Stathmin can serve as a potential marker in the diagnosis and prognosis of breast cancer.
2013, 37(7): 824-826.
Abstract:
Objective: To measure the distance of mandibular canal to the lower edge of mandible and tooth root to the alveolar crest.Methods:The panoramic tooth slice of 100 heathy 18 to 40 years old humans without periodontal disease were detected,and which were divided into man and woman group.The distance of tube edge,tube root and tube crest of all people were measured.Results:The distance of tube edge,tube root and tube crest were 5 to 12 cm,1.5 to 10 cm and 14.5 to 23 cm,respectively.The root tip point ligature of tooth 5,6 and 7 was circular arc line with the center of nasal bone root.The mandible lower edge and alveolar ridge top ligature were concentric relationship with the center of nasal bone root.There were not significant differences between man and woman group(P 0.05).Conclusions:According to the two-dimensional position characteristics of the mandible,the vertical position characteristics are feasible,it can provide a theoretical basis for mandibular fracture rigid internal fixation,tooth extraction,root canal treatment.
Objective: To measure the distance of mandibular canal to the lower edge of mandible and tooth root to the alveolar crest.Methods:The panoramic tooth slice of 100 heathy 18 to 40 years old humans without periodontal disease were detected,and which were divided into man and woman group.The distance of tube edge,tube root and tube crest of all people were measured.Results:The distance of tube edge,tube root and tube crest were 5 to 12 cm,1.5 to 10 cm and 14.5 to 23 cm,respectively.The root tip point ligature of tooth 5,6 and 7 was circular arc line with the center of nasal bone root.The mandible lower edge and alveolar ridge top ligature were concentric relationship with the center of nasal bone root.There were not significant differences between man and woman group(P 0.05).Conclusions:According to the two-dimensional position characteristics of the mandible,the vertical position characteristics are feasible,it can provide a theoretical basis for mandibular fracture rigid internal fixation,tooth extraction,root canal treatment.
2013, 37(7): 826-828.
Abstract:
Objective: To explore the curative effects of operation in the treatment of open floating knee injury.Methods:Twenty-six patients with open floating knee injury were treated with operation,and were classified according to the fracture type and open injury.All cases were traeted with emergency debridement.The fracture was treated with external fixation,plate and intramedullary fixation.The injury soft tissue was repaired with primary suture,skin grafting and tissue flap transposition.Results:Except 1 case of amputation,25 cases were follwed up for 6 months to 6 years.The fracture healing of 22 cases were good,its healing time ranged from 3 to 8 months.The fracture of 2 cases healed by bone grafting.All tissue flap transposition survived.According to the Karlstrom and Olerud's criteria for ipsilateral femoral and tibial fracture,9 cases were excellent,11 cases were good,4 cases were fair and 2 cases were poor. Conclusions:During the treatment of open floating knee injury,the reconstruction of the bone continuity should be paid attention to,but pay more attention to the soft tissue repair,combined injury treatment,treatment order and measures and regaining the function maximally.
Objective: To explore the curative effects of operation in the treatment of open floating knee injury.Methods:Twenty-six patients with open floating knee injury were treated with operation,and were classified according to the fracture type and open injury.All cases were traeted with emergency debridement.The fracture was treated with external fixation,plate and intramedullary fixation.The injury soft tissue was repaired with primary suture,skin grafting and tissue flap transposition.Results:Except 1 case of amputation,25 cases were follwed up for 6 months to 6 years.The fracture healing of 22 cases were good,its healing time ranged from 3 to 8 months.The fracture of 2 cases healed by bone grafting.All tissue flap transposition survived.According to the Karlstrom and Olerud's criteria for ipsilateral femoral and tibial fracture,9 cases were excellent,11 cases were good,4 cases were fair and 2 cases were poor. Conclusions:During the treatment of open floating knee injury,the reconstruction of the bone continuity should be paid attention to,but pay more attention to the soft tissue repair,combined injury treatment,treatment order and measures and regaining the function maximally.
2013, 37(7): 829-830,833.
Abstract:
Objective: To investigate the outcome and prognosis of thrombolytic therapy in patients with cerebral infarction.Methods:Two hundred and ten cases with cerebral infarction were randomly selected,in which,97 patients were received thrombolytic therapy,another 113 patients were received conventional treatment.Results:The NIHSS scores of various stages in thrombolysis group had significant difference after-treatment (P0.01) ; the Barthel index after treatment for 90d had statistical significance between the thrombolytic therapy group and conventional group (P0.01).The total effective rate in thrombolytic therapy group was 90.72%,which was higher than 73.45% in conventional group (P0.01).Conclusions:Thrombolytic therapy had an important effect on postoperative life quality in cerebral infarction patients,this treatment can improve neurological function recovery and life skills,then improve life quality.
Objective: To investigate the outcome and prognosis of thrombolytic therapy in patients with cerebral infarction.Methods:Two hundred and ten cases with cerebral infarction were randomly selected,in which,97 patients were received thrombolytic therapy,another 113 patients were received conventional treatment.Results:The NIHSS scores of various stages in thrombolysis group had significant difference after-treatment (P0.01) ; the Barthel index after treatment for 90d had statistical significance between the thrombolytic therapy group and conventional group (P0.01).The total effective rate in thrombolytic therapy group was 90.72%,which was higher than 73.45% in conventional group (P0.01).Conclusions:Thrombolytic therapy had an important effect on postoperative life quality in cerebral infarction patients,this treatment can improve neurological function recovery and life skills,then improve life quality.
2013, 37(7): 831-833.
Abstract:
Objective: To explore the application value of high press up method in cesarean section for fetal head embedded complicated with the second stage of labor stagnating or extending.Methods:One hundred and sixteen cases with cesarean section for fetal head embedded complicated with the second stage of labor stagnating or extending were randomly into the observation and control group(58 cases each group).The observation and control group were treated with high press up and conventional operation method (loose the fetal head by transvaginal push),respectively.The uterus incision laceration,uterine artery injury,blood loss,operation time,neonatal asphyxia rate and hospitalization time in two groups were compared.Results:The uterus incision laceration,uterine artery injury,blood loss,operation time,neonatal asphyxia rate and hospitalization time of observation group were less than those in control group(P0.01).Conclusions:The effects of high press up method in the treatment of fetal head embedded complicated with the second stage of labor stagnating or extending are good.
Objective: To explore the application value of high press up method in cesarean section for fetal head embedded complicated with the second stage of labor stagnating or extending.Methods:One hundred and sixteen cases with cesarean section for fetal head embedded complicated with the second stage of labor stagnating or extending were randomly into the observation and control group(58 cases each group).The observation and control group were treated with high press up and conventional operation method (loose the fetal head by transvaginal push),respectively.The uterus incision laceration,uterine artery injury,blood loss,operation time,neonatal asphyxia rate and hospitalization time in two groups were compared.Results:The uterus incision laceration,uterine artery injury,blood loss,operation time,neonatal asphyxia rate and hospitalization time of observation group were less than those in control group(P0.01).Conclusions:The effects of high press up method in the treatment of fetal head embedded complicated with the second stage of labor stagnating or extending are good.
2013, 37(7): 834-835.
Abstract:
Objective: To compare the effects of laparoscopic enterolysis with open enterolysis in the treatment of adhesive intestinal obstruction and explore the feasibility of laparoscopic enterolysis.Methods:The clinical effects of 36 cases treated with laparoscopic enterolysis(laparoscopy group) and 42 cases treated with open enterolysis(open group) were compared.Results:Compared with the open group,the operation time and postoperative hospital stay were significantly shorter,intra-operative blood loss and postoperative complications were significantly less,and postoperative eating time were significantly earlier in laparoscopy group (P0.05 to P0.01).Conclusions:Laparoscopic enterolysis is short operation time and quick recovery,which is worthy of being widely applied in clinic.
Objective: To compare the effects of laparoscopic enterolysis with open enterolysis in the treatment of adhesive intestinal obstruction and explore the feasibility of laparoscopic enterolysis.Methods:The clinical effects of 36 cases treated with laparoscopic enterolysis(laparoscopy group) and 42 cases treated with open enterolysis(open group) were compared.Results:Compared with the open group,the operation time and postoperative hospital stay were significantly shorter,intra-operative blood loss and postoperative complications were significantly less,and postoperative eating time were significantly earlier in laparoscopy group (P0.05 to P0.01).Conclusions:Laparoscopic enterolysis is short operation time and quick recovery,which is worthy of being widely applied in clinic.
2013, 37(7): 836-838.
Abstract:
Objective: To investigate the effects of obesity on the clinical efficacy of percutaneous nephrolithotomy(PCNL).Methods:Ninety-eight patients treated with PCNL were divided into the control group and obesity group according to the body mass index.The clinical efficacy of two groups were compared.Results:There were not significantly statistical differences in the sex,age,blood loss,stone position,hospital stays,postoperative complication and anticoagulants use between the two groups(P0.05).The operative time in obesity group(82.46 12.79 min) was longer than that in control group(73.54 8.26min) (P0.01).The stone-free rate in obesity group(62.0%) was lower than that in control group(81.3%) (P0.05).Conclusions:The PCNL in obese patients is a safe and feasible method,but strengthening monitoring and postoperative residual stone processing should be pay more attention to.
Objective: To investigate the effects of obesity on the clinical efficacy of percutaneous nephrolithotomy(PCNL).Methods:Ninety-eight patients treated with PCNL were divided into the control group and obesity group according to the body mass index.The clinical efficacy of two groups were compared.Results:There were not significantly statistical differences in the sex,age,blood loss,stone position,hospital stays,postoperative complication and anticoagulants use between the two groups(P0.05).The operative time in obesity group(82.46 12.79 min) was longer than that in control group(73.54 8.26min) (P0.01).The stone-free rate in obesity group(62.0%) was lower than that in control group(81.3%) (P0.05).Conclusions:The PCNL in obese patients is a safe and feasible method,but strengthening monitoring and postoperative residual stone processing should be pay more attention to.
2013, 37(7): 838-839.
Abstract:
Objective: To explore the feasibility and safety of renal cyst unroofing decompression through laparoscopic retroperitoneal approaches based on self-made single span.Methods:The clinical data of 11 patients undergone renal cyst unroofing decompression through single span laparoscopic retroperitoneal approaches were retrospectively analyzed.Results:All operations were smooth and no transfer open.The time of operation was 55 to 75 minutes,intraoperative bleeding was 15 to 50 ml and postoperative hospitalization was 3 to 7 days.Conclusions:The self-made single span laparoscopic retroperitoneal approaches for renal cyst unroofing decompression is feasible and safe.
Objective: To explore the feasibility and safety of renal cyst unroofing decompression through laparoscopic retroperitoneal approaches based on self-made single span.Methods:The clinical data of 11 patients undergone renal cyst unroofing decompression through single span laparoscopic retroperitoneal approaches were retrospectively analyzed.Results:All operations were smooth and no transfer open.The time of operation was 55 to 75 minutes,intraoperative bleeding was 15 to 50 ml and postoperative hospitalization was 3 to 7 days.Conclusions:The self-made single span laparoscopic retroperitoneal approaches for renal cyst unroofing decompression is feasible and safe.
2013, 37(7): 840-842.
Abstract:
Objective: To compare the clinical effects and adverse reactions of aripiprazole and risperidone combined with lithium carbonate in the treatment of bipolar disorder manic episode.Methods:Sixty patients diagnosed by the criteria of ICD-10 bipolar disorder manic episode were randomly divided into aripiprazole group and risperidone group(30 cases each group),which were treated with aripiprazole combined with lithium carbonate and risperidone combined with lithium carbonate for 6 weeks respectively.The clinical effects and adverse reactions in two groups were evaulated using the mania rating scale (BRMS) and the side effects scale (TESS),respectively.Results:The BRMS scores in two groups at 1 to 6 weeks after treatment were significantly lower than those before treatment(P0.01),but the BRMS score of aripiprazole group was lower than that in risperidone group at 1 week after treatment(P 0.05).The clinical effects differences between two groups had statistical significance(P0.05).Conclusions:There is no difference between the clinical effects of aripiprazole and risperidone combined with lithium carbonate in the treatment of bipolar disorder manic episode.
Objective: To compare the clinical effects and adverse reactions of aripiprazole and risperidone combined with lithium carbonate in the treatment of bipolar disorder manic episode.Methods:Sixty patients diagnosed by the criteria of ICD-10 bipolar disorder manic episode were randomly divided into aripiprazole group and risperidone group(30 cases each group),which were treated with aripiprazole combined with lithium carbonate and risperidone combined with lithium carbonate for 6 weeks respectively.The clinical effects and adverse reactions in two groups were evaulated using the mania rating scale (BRMS) and the side effects scale (TESS),respectively.Results:The BRMS scores in two groups at 1 to 6 weeks after treatment were significantly lower than those before treatment(P0.01),but the BRMS score of aripiprazole group was lower than that in risperidone group at 1 week after treatment(P 0.05).The clinical effects differences between two groups had statistical significance(P0.05).Conclusions:There is no difference between the clinical effects of aripiprazole and risperidone combined with lithium carbonate in the treatment of bipolar disorder manic episode.
2013, 37(7): 842-843.
Abstract:
Objective: To investigate the related factors of influencing orthodontic compliance.Methods:Four hundred patients with orthodontic treatment were surveyed by questionnaire,and their clinical data were analyzed.Among them there are 52 children,25 teenages,95 adults.Results:The results of questionnaire investigation of children,senior and teenager group were not statistical significance(P0.05).The difference of clinical case compliance of three group was statistical significance(P0.01),the clinical case compliance of teenager group was lower than that of senior group(P0.01).Conclusions:Good doctor patient relationships and necessary intervention can improve the compliance of orthodontic patients.
Objective: To investigate the related factors of influencing orthodontic compliance.Methods:Four hundred patients with orthodontic treatment were surveyed by questionnaire,and their clinical data were analyzed.Among them there are 52 children,25 teenages,95 adults.Results:The results of questionnaire investigation of children,senior and teenager group were not statistical significance(P0.05).The difference of clinical case compliance of three group was statistical significance(P0.01),the clinical case compliance of teenager group was lower than that of senior group(P0.01).Conclusions:Good doctor patient relationships and necessary intervention can improve the compliance of orthodontic patients.
2013, 37(7): 844-846.
Abstract:
Objective: To evaluate the clinical effects of clopidogrel combined with aspirin in the treatment of progressive cerebral infarction and their impacts on neural function deficit and blood coagulation.Methods:Ninety-two cases with progressive cerebral infarction were randomly divided into two groups.The control and observation group(46 cases each group) were treated with aspirin and aspirin combined with clopidogrel by oral,respectively.The clinical effects,neural function deficit score and blood coagulation function in two groups were compared.Results:The total effective rates of the observation and control group were 91.3% and 80.4%,respectively,the difference of which was not statistical significance(P0.05).After treatment,the neurological deficit scores of the observation group were significantly lower than that in control group(P0.01),the fibrinogen levels,plasma viscosity and erythrocyte aggregation index of the observation group were significantly lower than that in control group(P0.05 to P0.01).Conclusions:Clopidogrel combined with aspirin in the treatment of progressive cerebral infarction is good,which can effectively improve the patient's neurological and blood coagulation function,and be worthy of application.
Objective: To evaluate the clinical effects of clopidogrel combined with aspirin in the treatment of progressive cerebral infarction and their impacts on neural function deficit and blood coagulation.Methods:Ninety-two cases with progressive cerebral infarction were randomly divided into two groups.The control and observation group(46 cases each group) were treated with aspirin and aspirin combined with clopidogrel by oral,respectively.The clinical effects,neural function deficit score and blood coagulation function in two groups were compared.Results:The total effective rates of the observation and control group were 91.3% and 80.4%,respectively,the difference of which was not statistical significance(P0.05).After treatment,the neurological deficit scores of the observation group were significantly lower than that in control group(P0.01),the fibrinogen levels,plasma viscosity and erythrocyte aggregation index of the observation group were significantly lower than that in control group(P0.05 to P0.01).Conclusions:Clopidogrel combined with aspirin in the treatment of progressive cerebral infarction is good,which can effectively improve the patient's neurological and blood coagulation function,and be worthy of application.
2013, 37(7): 846-848.
Abstract:
Objective: To investigate the clinical characteristics,diagnosis and treatment of thyroid cancer.Methods:The clinical data of 47 patients with thyroid cancer were retrospectively analysed.Results:Coincidence rate of preoperative diagnosis through ultrasonography was 53.19%.Papillary carcinoma in 39 cases,follicular carcinoma in 5 cases,medullary carcinoma in 1 case and anaplastic carcinoma in 2 cases were found.Cervical lymph node metastasis in 10 cases were found including thyroid membrane invasion in 6 cases,trachea invasion in 1 case,neck muscle in 3 cases and recurrent laryngeal nerve in 2 cases.Seven cases with nodular goiter,1 case with hyperthyroidism,2 cases with Hashimoto disease and 1 case with thyroid adenoma were detected.Coincidence rate of clinical and pathological diagnosis was 40.43%.Complication,included transient hoarseness in 3 cases and temporary convulision in 4 cases.Conclusions:The differentiated thyroid carcinoma was the main form of thyroid cancer,its clinical symptom was not specificity. Operation resection is the main method in the treatment of thyroid cancer,the choice of surgical method should be based on the nature of the lesions,staging and patient status.
Objective: To investigate the clinical characteristics,diagnosis and treatment of thyroid cancer.Methods:The clinical data of 47 patients with thyroid cancer were retrospectively analysed.Results:Coincidence rate of preoperative diagnosis through ultrasonography was 53.19%.Papillary carcinoma in 39 cases,follicular carcinoma in 5 cases,medullary carcinoma in 1 case and anaplastic carcinoma in 2 cases were found.Cervical lymph node metastasis in 10 cases were found including thyroid membrane invasion in 6 cases,trachea invasion in 1 case,neck muscle in 3 cases and recurrent laryngeal nerve in 2 cases.Seven cases with nodular goiter,1 case with hyperthyroidism,2 cases with Hashimoto disease and 1 case with thyroid adenoma were detected.Coincidence rate of clinical and pathological diagnosis was 40.43%.Complication,included transient hoarseness in 3 cases and temporary convulision in 4 cases.Conclusions:The differentiated thyroid carcinoma was the main form of thyroid cancer,its clinical symptom was not specificity. Operation resection is the main method in the treatment of thyroid cancer,the choice of surgical method should be based on the nature of the lesions,staging and patient status.
2013, 37(7): 849-851.
Abstract:
Objective: To investigate the clinical features and treatment of the aged patients with severe craniocerebral trauma.Methods:The clinical data of aged patients with severe craniocerebral trauma including 28 cases treated with operation and 14 cases treated with non-operation from May 2003 to Feb.2012 were retrospectively analyzed.Results:Twenty-three cases survived,which included good recovery in 8 cases,moderate disability in 10 cases and severe disability in 5 cases according to the Glasgow outcome scale.Nineteen cases died.Conclusions:Severe craniocerebral trauma in the elderly is a critical disease and high mortality.Correct diagnosis,timely treatment and active prevention complications are the keys to reduce the secondary craniocerebral trauma and increase survival rate.
Objective: To investigate the clinical features and treatment of the aged patients with severe craniocerebral trauma.Methods:The clinical data of aged patients with severe craniocerebral trauma including 28 cases treated with operation and 14 cases treated with non-operation from May 2003 to Feb.2012 were retrospectively analyzed.Results:Twenty-three cases survived,which included good recovery in 8 cases,moderate disability in 10 cases and severe disability in 5 cases according to the Glasgow outcome scale.Nineteen cases died.Conclusions:Severe craniocerebral trauma in the elderly is a critical disease and high mortality.Correct diagnosis,timely treatment and active prevention complications are the keys to reduce the secondary craniocerebral trauma and increase survival rate.
2013, 37(7): 851-853.
Abstract:
Objective: To investigate the longterm effects of sleeve lobectomy in the treatment of central lung cancer in older patients.Methods:Eighty-three patients with central lung cancer treated with sleeve lobectomy were divided into older group(36 cases) and non-older group (47 cases).The 5-year survival rate and some clinical data of two groups were analysed.Results:No seriously postoperative complications in two groups were found.The postoperative forced vital capacity(FVC) and forced expiratory volume in 1 second(FVC1) and the ratio of FVC to FVC1 of two groups after operation were less than those in preoperation (P0.01).The differences of the postoperatively clinical data of two groups were not statistical significance(P0.05).The 3-year and 5-year survival rates in elder group and non-older group were 61.1% ＆ 52.8% and 61.7% ＆ 53.2%,respectively,the differences of which were not statistical significance(P0.05).Conclusions:Sleeve lobectomy in the treatment of central lung cancer in older patients is safe,less complications and high survival rate,which can reserve lung function of patients in large degree and be worthy of clinical application.
Objective: To investigate the longterm effects of sleeve lobectomy in the treatment of central lung cancer in older patients.Methods:Eighty-three patients with central lung cancer treated with sleeve lobectomy were divided into older group(36 cases) and non-older group (47 cases).The 5-year survival rate and some clinical data of two groups were analysed.Results:No seriously postoperative complications in two groups were found.The postoperative forced vital capacity(FVC) and forced expiratory volume in 1 second(FVC1) and the ratio of FVC to FVC1 of two groups after operation were less than those in preoperation (P0.01).The differences of the postoperatively clinical data of two groups were not statistical significance(P0.05).The 3-year and 5-year survival rates in elder group and non-older group were 61.1% ＆ 52.8% and 61.7% ＆ 53.2%,respectively,the differences of which were not statistical significance(P0.05).Conclusions:Sleeve lobectomy in the treatment of central lung cancer in older patients is safe,less complications and high survival rate,which can reserve lung function of patients in large degree and be worthy of clinical application.
2013, 37(7): 854-855,858.
Abstract:
Objective: To study the clinical significance of telmisartan treatment on insulin sensitivity and endothelial function in elderly diabetic patients with hypertension.Methods:Sixty-eight elderly diabetic patients with hypertension were randomly selected in our hospital,and divided into two groups,the patents in study group (34 cases) were required regular quantitative taking alternate telmisartan 40 mg per day treatment; the patients in control group(34 cases) taking amlodipine 2.5 mg per day,the insulin sensitivity including fasting blood glucose(FBG) level,fasting insulin(FINS),insulin resistance index(IRI) and vascular endothelial function including the changes of endothelin-1(ET-1) and nitric oxide(NO) were observed.Results:Compared with the control group,FBG,FINS,IRI in the study group were decreased after telmisartan treatment (P0.01) ; compared with the control group,there had statistical differences of ET-1 and NO in the study group after telmisartan treatment(P0.01 and P0.05).Conclusions:Telmisartan can effectively improve insulin sensitivity and endothelial function in elderly diabetic patients with hypertension.
Objective: To study the clinical significance of telmisartan treatment on insulin sensitivity and endothelial function in elderly diabetic patients with hypertension.Methods:Sixty-eight elderly diabetic patients with hypertension were randomly selected in our hospital,and divided into two groups,the patents in study group (34 cases) were required regular quantitative taking alternate telmisartan 40 mg per day treatment; the patients in control group(34 cases) taking amlodipine 2.5 mg per day,the insulin sensitivity including fasting blood glucose(FBG) level,fasting insulin(FINS),insulin resistance index(IRI) and vascular endothelial function including the changes of endothelin-1(ET-1) and nitric oxide(NO) were observed.Results:Compared with the control group,FBG,FINS,IRI in the study group were decreased after telmisartan treatment (P0.01) ; compared with the control group,there had statistical differences of ET-1 and NO in the study group after telmisartan treatment(P0.01 and P0.05).Conclusions:Telmisartan can effectively improve insulin sensitivity and endothelial function in elderly diabetic patients with hypertension.
2013, 37(7): 856-858.
Abstract:
Objective: To evaluate the effect of phacoemulsfication and intraocular lens implantation on axial high myopic patients combined with cataract.Methods:Twenty-two patients (38 eyes) with axial high myopia complicated by cataract received phacoemulsfication and implantation of intraocular soft lens under topical anesthesia.The preoperative corrected visual acuity and axial length were recorded; the pain during operation,postoperative effect and complication,and the diopter and expectancy bias of diopter were observed.Results:The preoperative axial length was 26.11 ～ 31.28 mm and the intraocular lens degree was 0D ～ + 15D.During the operation,34 eyes felt no pain,4 eyes a little distending pain and 2 eyes had posterior capsule rupture.Three months after the operation,19 eyes reached a corrected visual acuity of 0.1 ～ 0.4 and 18 eyes more than 0.5.Conclusions:Phacoemulsfication along with intraocular lens implantation under topical anesthesia is a safe and effective procedure for improving the visual acuity of patients with axial high myopia combined with cataract.
Objective: To evaluate the effect of phacoemulsfication and intraocular lens implantation on axial high myopic patients combined with cataract.Methods:Twenty-two patients (38 eyes) with axial high myopia complicated by cataract received phacoemulsfication and implantation of intraocular soft lens under topical anesthesia.The preoperative corrected visual acuity and axial length were recorded; the pain during operation,postoperative effect and complication,and the diopter and expectancy bias of diopter were observed.Results:The preoperative axial length was 26.11 ～ 31.28 mm and the intraocular lens degree was 0D ～ + 15D.During the operation,34 eyes felt no pain,4 eyes a little distending pain and 2 eyes had posterior capsule rupture.Three months after the operation,19 eyes reached a corrected visual acuity of 0.1 ～ 0.4 and 18 eyes more than 0.5.Conclusions:Phacoemulsfication along with intraocular lens implantation under topical anesthesia is a safe and effective procedure for improving the visual acuity of patients with axial high myopia combined with cataract.
2013, 37(7): 859-861.
Abstract:
Objective: To explore the risk and clinical value of laparoscope and laparotomy in resecting hysteromyoma.Methods:The intramural or subserosal hysteromyoma of 56 patients were resected by laparoscope and laparotomy,and these patients were divided into laparoscope and laparotomy group,respectively(each group 28 cases).The operation time,the hospital stays,the amount of bleeding during operation,the time of independent activity,body temperature recovery and anal exhaust after operation,the postoperative analgesic drug use,the postoperative highest body temperature,the blood routine test at 3 days after operation and the postoperative complications of two groups were investigated by match method.Results:The hospital stays,the amount of bleeding during operation,the time of independent activity,body temperature recovery and anal exhaust after operation,the postoperative analgesic drug use,the time of postoperative blood routine recovery of laparoscope group were less than those in laparotomy group (P0.05 to P0.01).The operation time of laparoscope group was longer than that of laparotomy group(P0.01).Conclusions:Compared with the laparotomy group,laparoscopic myomectomy is safe,effective,small trauma,less intraoperative bleeding and rapid recovery.
Objective: To explore the risk and clinical value of laparoscope and laparotomy in resecting hysteromyoma.Methods:The intramural or subserosal hysteromyoma of 56 patients were resected by laparoscope and laparotomy,and these patients were divided into laparoscope and laparotomy group,respectively(each group 28 cases).The operation time,the hospital stays,the amount of bleeding during operation,the time of independent activity,body temperature recovery and anal exhaust after operation,the postoperative analgesic drug use,the postoperative highest body temperature,the blood routine test at 3 days after operation and the postoperative complications of two groups were investigated by match method.Results:The hospital stays,the amount of bleeding during operation,the time of independent activity,body temperature recovery and anal exhaust after operation,the postoperative analgesic drug use,the time of postoperative blood routine recovery of laparoscope group were less than those in laparotomy group (P0.05 to P0.01).The operation time of laparoscope group was longer than that of laparotomy group(P0.01).Conclusions:Compared with the laparotomy group,laparoscopic myomectomy is safe,effective,small trauma,less intraoperative bleeding and rapid recovery.
2013, 37(7): 869-872.
Abstract:
Objective: To optimize the thermosensitive in situ gel system containing antofloxacin for ocular use by the central composite design-response surface methodology.Methods:The in situ thermosensitive gel system containing antofloxacin was prepared with Poloxamer 407 and Poloxamer 188.The phase transition temperature of the solution-gel before and after the STF dilution was used as index.The mathematic relation of the factors and indicators,effective surface figure and contour map were described using binomial model.The formulation was optimized and validated by superimposed contour plot.Results:Optimized formulation of in situ thermosensitive gel system containing antofloxacin for ocular use consisted of 22.5% of Poloxamer 407 and 1.0% of Poloxamer 188,which was a free-flowing liquid at room temperature and converted to firm gel after STF dilution.Conclusions:The thermosensitive in situ gel system containing antofloxacin hydrochloride satisfied the requirement of ophthalmic application,which has clinical significance and application value.
Objective: To optimize the thermosensitive in situ gel system containing antofloxacin for ocular use by the central composite design-response surface methodology.Methods:The in situ thermosensitive gel system containing antofloxacin was prepared with Poloxamer 407 and Poloxamer 188.The phase transition temperature of the solution-gel before and after the STF dilution was used as index.The mathematic relation of the factors and indicators,effective surface figure and contour map were described using binomial model.The formulation was optimized and validated by superimposed contour plot.Results:Optimized formulation of in situ thermosensitive gel system containing antofloxacin for ocular use consisted of 22.5% of Poloxamer 407 and 1.0% of Poloxamer 188,which was a free-flowing liquid at room temperature and converted to firm gel after STF dilution.Conclusions:The thermosensitive in situ gel system containing antofloxacin hydrochloride satisfied the requirement of ophthalmic application,which has clinical significance and application value.
2013, 37(7): 872-875.
Abstract:
Objective: To explore the relationship between the exact mortality,common risk factors and medication data of the patients infected byKlebsiella pneumoniaecarbapenemase(KPC) production strains in this region.Methods:With the help of electric medical record and the chart,the clinical data of 82 cases infected by KPC-producing strains in department of microbiology in our hospital were analyzed retrospectively.Results:Among these 82 patients,66 cases were infected by KPC / ESBL co-producing isolates,16 cases were infected by KPC producing isolates only.The mortality was 30 cases(45.5%) and 5 cases(31.3%) respectively,and there was no statistical significance(P0.05).In Cox regression analysis,treatment with sulfuric acid polymyxin B had obvious effect(P0.01). Conclusions:The treatment with sulfuric acid polymyxin B had certain herapeutic effect on patients infected by KPC-producing strains.
Objective: To explore the relationship between the exact mortality,common risk factors and medication data of the patients infected byKlebsiella pneumoniaecarbapenemase(KPC) production strains in this region.Methods:With the help of electric medical record and the chart,the clinical data of 82 cases infected by KPC-producing strains in department of microbiology in our hospital were analyzed retrospectively.Results:Among these 82 patients,66 cases were infected by KPC / ESBL co-producing isolates,16 cases were infected by KPC producing isolates only.The mortality was 30 cases(45.5%) and 5 cases(31.3%) respectively,and there was no statistical significance(P0.05).In Cox regression analysis,treatment with sulfuric acid polymyxin B had obvious effect(P0.01). Conclusions:The treatment with sulfuric acid polymyxin B had certain herapeutic effect on patients infected by KPC-producing strains.
2013, 37(7): 876-878,883.
Abstract:
Objective: To analyze time and space distribution characteristics in Anhui province between 2006 and 2010.Methods:The malaria occurrence data from 2006 to 2010 in China were collected and analyzed,and the national geographic distribution map of malaria incidence was established.The annual and seasonal incidences of malaria prevalence in Anhui province were analyzed.Results:There were 83 553 cases of malaria reported from 2006 to 2010 in Anhui province,ranked first in our country.And the average annual incidence rate was about 27.32 per 100 000.The seasonal incidence of malaria was increased from May,and reached the peak between June and October,then decreased gradually.From 2006 to 2010,malaria incidence was ranked top 10,in addition to 2010 for NO.16.In the legal report infectious diseases(Class A and Class B),it was ranked No.1 in the natural focal diseases and insect-borne infectious diseases.Conclusions:The incidence of malaria was decreased year by year in Anhui province during the period between 2006 and 2010,but still ranked No.1 or No.2 in China.Malaria was unstable and had the highest incidence of insect-borne infectious diseases in Anhui province,which still need to pay more attention to prevention and control.
Objective: To analyze time and space distribution characteristics in Anhui province between 2006 and 2010.Methods:The malaria occurrence data from 2006 to 2010 in China were collected and analyzed,and the national geographic distribution map of malaria incidence was established.The annual and seasonal incidences of malaria prevalence in Anhui province were analyzed.Results:There were 83 553 cases of malaria reported from 2006 to 2010 in Anhui province,ranked first in our country.And the average annual incidence rate was about 27.32 per 100 000.The seasonal incidence of malaria was increased from May,and reached the peak between June and October,then decreased gradually.From 2006 to 2010,malaria incidence was ranked top 10,in addition to 2010 for NO.16.In the legal report infectious diseases(Class A and Class B),it was ranked No.1 in the natural focal diseases and insect-borne infectious diseases.Conclusions:The incidence of malaria was decreased year by year in Anhui province during the period between 2006 and 2010,but still ranked No.1 or No.2 in China.Malaria was unstable and had the highest incidence of insect-borne infectious diseases in Anhui province,which still need to pay more attention to prevention and control.
2013, 37(7): 879-883.
Abstract:
Objective: To evaluate the effects of dietary nutrition health education on preschool children in Bengbu and provide the basis for establishing effective nutrition intervention model.Methods:Eight hundred and seventy-nine children(2 to 6 years old) were randomly selected,and divided into intervention group(496 cases) and control group(383 cases).The intervention group were educated for 1 year.Parents were surveyed by knowledge-attitude-practice questionnaire,physical examination of children in the intervention group were investigated before and after health education.Results:The growth status of children and nutrition knowledge levels of parents in intervention group after intervention were better than those in before intervention and control group (P0.01).The proportion of children who drunk milk and had breakfast everyday increased significantly,the proportion of children who had specific food preference or prefer fast-food decreased significantly,the differenes of which were statistical significance(P0.01).Conclusions:Nutritional education can improve parents nutritional knowledge and promote preschool children to change their dietary behaviors.
Objective: To evaluate the effects of dietary nutrition health education on preschool children in Bengbu and provide the basis for establishing effective nutrition intervention model.Methods:Eight hundred and seventy-nine children(2 to 6 years old) were randomly selected,and divided into intervention group(496 cases) and control group(383 cases).The intervention group were educated for 1 year.Parents were surveyed by knowledge-attitude-practice questionnaire,physical examination of children in the intervention group were investigated before and after health education.Results:The growth status of children and nutrition knowledge levels of parents in intervention group after intervention were better than those in before intervention and control group (P0.01).The proportion of children who drunk milk and had breakfast everyday increased significantly,the proportion of children who had specific food preference or prefer fast-food decreased significantly,the differenes of which were statistical significance(P0.01).Conclusions:Nutritional education can improve parents nutritional knowledge and promote preschool children to change their dietary behaviors.
2013, 37(7): 886-888.
Abstract:
Objective: To investigate the application value of echocardiography in Hybrid operation for treating atrial septal defect(ASD).Methods:Fifteen cases with central ASD diagnosed by transthoracic echocardiography(TTE) before operation were treated with minimally invasive surgical plugging,the appropriate occluder was selected according to the maximum diameter of ASD using transesophageal echocardiography during operation.The sheath tube was guided through ASD,around atrial face umbrella was released and the plugging effect was immediately evaluated.All cases were followed up for 1 to 12 months by TTE.Results:The plugging operations of 13 cases were successful,1 case plugging operation was successful through replacing small occluder with large occluder,and 1 case plugging operation was failure because the residual of inferior vena cava was soft.Conclusions:The patients with ASD selected by echocardiography,appropriate occluder,intraoperative monitoring and postoperative following-up have important clinical value in the treatment of ASD with Hybrid operation.
Objective: To investigate the application value of echocardiography in Hybrid operation for treating atrial septal defect(ASD).Methods:Fifteen cases with central ASD diagnosed by transthoracic echocardiography(TTE) before operation were treated with minimally invasive surgical plugging,the appropriate occluder was selected according to the maximum diameter of ASD using transesophageal echocardiography during operation.The sheath tube was guided through ASD,around atrial face umbrella was released and the plugging effect was immediately evaluated.All cases were followed up for 1 to 12 months by TTE.Results:The plugging operations of 13 cases were successful,1 case plugging operation was successful through replacing small occluder with large occluder,and 1 case plugging operation was failure because the residual of inferior vena cava was soft.Conclusions:The patients with ASD selected by echocardiography,appropriate occluder,intraoperative monitoring and postoperative following-up have important clinical value in the treatment of ASD with Hybrid operation.
2013, 37(7): 889-891.
Abstract:
Objective: To analyze the transrectal ultrasonographic features and level of serum prostate specific antigen(PSA) of prostate cancer and improve its diagnosis rate.Methods:Ultrasonographic features and the levels of serum PSA of 30 cases with prostate cancer diagnosed by transrectal ultrasound-guided biopsy were classified and analysed.Results:Diffuse infiltration type were in 12 cases.Hypoechoic areas were found in the entire or a lobe of prostate,its boundary was not clear,local blood flow was rich and blood flow beam was random distribution.Infiltration with nodular type were in 5 cases.In addition to the above features,sphere node was found at the same location.Solitary nodular type were in 7 cases,solitary node were detected in prostate.Six cases had not abnormal ultrasonography.The serum PSA levels of 4 cases were from 4 - 10 ng / ml,the serum PSA levels of 8 cases were from 10 - 50 ng / ml and the serum PSA levels of 18 cases were higher than 50 ng / ml.Conclusions:The sonographic manifestation of prostate cancer has certain regularity,which can guide biopsy.Biopsy is recommended in patients with normal ultrasonography and less than 10 ng / m1 of serum PSA,which can improve the diagnosis rate of prostate cancer.
Objective: To analyze the transrectal ultrasonographic features and level of serum prostate specific antigen(PSA) of prostate cancer and improve its diagnosis rate.Methods:Ultrasonographic features and the levels of serum PSA of 30 cases with prostate cancer diagnosed by transrectal ultrasound-guided biopsy were classified and analysed.Results:Diffuse infiltration type were in 12 cases.Hypoechoic areas were found in the entire or a lobe of prostate,its boundary was not clear,local blood flow was rich and blood flow beam was random distribution.Infiltration with nodular type were in 5 cases.In addition to the above features,sphere node was found at the same location.Solitary nodular type were in 7 cases,solitary node were detected in prostate.Six cases had not abnormal ultrasonography.The serum PSA levels of 4 cases were from 4 - 10 ng / ml,the serum PSA levels of 8 cases were from 10 - 50 ng / ml and the serum PSA levels of 18 cases were higher than 50 ng / ml.Conclusions:The sonographic manifestation of prostate cancer has certain regularity,which can guide biopsy.Biopsy is recommended in patients with normal ultrasonography and less than 10 ng / m1 of serum PSA,which can improve the diagnosis rate of prostate cancer.
2013, 37(7): 892-894.
Abstract:
Objective: To investigate the magnetic resonance imaging(MRI) features of hemangioblastoma in different encephalic parts.Methods:The data of 16 cases with hemangioblastoma confirmed by surgery and pathology in different encephalic parts were retrospectively analyzed.Results:Four cases in frontal lobe,1 case in left cerebellopontine angle area,2 cases in medulla oblongata and 9 cases in cerebellar hemisphere were found.Twelve cases were large cyst and small nodular type,4 cases were substance type.Frontal lobe lesions were large cyst and small nodular type,many signal voids of vessel in tumor were observed,the enahnced T1 and T2 signals were showed in tumor substance.The cerebellopontine angle lesions were irregular cysts,distorted vascular shadow and irregular substance in tumor were found.Medullary lesions were oval large cyst and small nodular,separations in inside and obvious strengthening were found.Cerebellar hemisphere lesions were large cyst and small nodular or substance type,the enahnced T1 and T2 signals and signal voids of vessel were showed in substance of tumor and solid part was obviously strengthened.Conclusions:The MRI feactures of hemangioblastoma in different encephalic parts have certain characteristics,the signal voids of vessel in tumor lesion is the characterictic feature.
Objective: To investigate the magnetic resonance imaging(MRI) features of hemangioblastoma in different encephalic parts.Methods:The data of 16 cases with hemangioblastoma confirmed by surgery and pathology in different encephalic parts were retrospectively analyzed.Results:Four cases in frontal lobe,1 case in left cerebellopontine angle area,2 cases in medulla oblongata and 9 cases in cerebellar hemisphere were found.Twelve cases were large cyst and small nodular type,4 cases were substance type.Frontal lobe lesions were large cyst and small nodular type,many signal voids of vessel in tumor were observed,the enahnced T1 and T2 signals were showed in tumor substance.The cerebellopontine angle lesions were irregular cysts,distorted vascular shadow and irregular substance in tumor were found.Medullary lesions were oval large cyst and small nodular,separations in inside and obvious strengthening were found.Cerebellar hemisphere lesions were large cyst and small nodular or substance type,the enahnced T1 and T2 signals and signal voids of vessel were showed in substance of tumor and solid part was obviously strengthened.Conclusions:The MRI feactures of hemangioblastoma in different encephalic parts have certain characteristics,the signal voids of vessel in tumor lesion is the characterictic feature.
2013, 37(7): 895-896.
Abstract:
Objective: To investigate the value of ultrasound in the diagnosis of gallstone in fetus.Methods:Twenty-one thousand and twenty pregnant women were prenatally examined by ultrasound,the data of gallstone in 15 fetuses were analysed.Results:Among 15 fetuses,the gestational age of 11 cases,2 cases and 2 cases were closed to,more than and less than normal,respectively.The granular,lumpy and banded strong echo in fetal gallbladder and few posterior echo enhancement were found,which disappeared in 12 cases in 2 weeks and 3 cases in 6 months after birth.Conclusions:Ultrasound can show the strong echo of fetal gallbladder,which has an important value in the diagnosis of fetal gallstone.
Objective: To investigate the value of ultrasound in the diagnosis of gallstone in fetus.Methods:Twenty-one thousand and twenty pregnant women were prenatally examined by ultrasound,the data of gallstone in 15 fetuses were analysed.Results:Among 15 fetuses,the gestational age of 11 cases,2 cases and 2 cases were closed to,more than and less than normal,respectively.The granular,lumpy and banded strong echo in fetal gallbladder and few posterior echo enhancement were found,which disappeared in 12 cases in 2 weeks and 3 cases in 6 months after birth.Conclusions:Ultrasound can show the strong echo of fetal gallbladder,which has an important value in the diagnosis of fetal gallstone.
2013, 37(7): 897-898,901.
Abstract:
Objective: To investigate the effects of antioxidant treatment on male sperm DNA fragmentation in couples with early unexplained recurrent spontaneous abortion.Methods:Forty-two cases with more than or equal to 15% of sperm DNA fragmentation rate were treated with antioxidant(treatment group),their semen routine and sperm DNA fragmentation rate were detected in 3 months after treatment.The antioxidant treatment was not used in 23 cases with less than 15% of sperm DNA fragmentation rate(control group).The pregnancy and abortion rate of two groups were compared after 1 year.Results:Compared with pretreatment in treatment group,the sperm density and spermatic forward movement rate were significantly higher (P0.01),the sperm DNA fragmentation rate was significantly lower(P0.01) and the difference of sperm morphology rate was not statistical significance after treatment(P0.05).The pregnancy rate of treatment group(66.7%) was higher than that in control group(25.0%) (P0.05).Conclusions:Antioxidant treatment is a effective means to reduce the sperm DNA fragmentation rate in couples with early unexplained recurrent spontaneous abortion.
Objective: To investigate the effects of antioxidant treatment on male sperm DNA fragmentation in couples with early unexplained recurrent spontaneous abortion.Methods:Forty-two cases with more than or equal to 15% of sperm DNA fragmentation rate were treated with antioxidant(treatment group),their semen routine and sperm DNA fragmentation rate were detected in 3 months after treatment.The antioxidant treatment was not used in 23 cases with less than 15% of sperm DNA fragmentation rate(control group).The pregnancy and abortion rate of two groups were compared after 1 year.Results:Compared with pretreatment in treatment group,the sperm density and spermatic forward movement rate were significantly higher (P0.01),the sperm DNA fragmentation rate was significantly lower(P0.01) and the difference of sperm morphology rate was not statistical significance after treatment(P0.05).The pregnancy rate of treatment group(66.7%) was higher than that in control group(25.0%) (P0.05).Conclusions:Antioxidant treatment is a effective means to reduce the sperm DNA fragmentation rate in couples with early unexplained recurrent spontaneous abortion.
2013, 37(7): 899-901.
Abstract:
Objective: To explore the effects of nursing intervention on complication of immediate breast reconstruction with keeping the nipple areola complex(NAC) in the modified radical operation of early breast cancer.Methods:Sixty-two cases with early breast cancer treated with immediate breast reconstruction with keeping NAC in the modified radical operation were divided into control group(30 cases) and observation group(32 cases).The control group were given routine nursing after radical operation,the observation group were given nursing intervention after immediate breast reconstruction in the modified radical operation.The incidence of postoperative complication in two group was compared.Results:Skin flap necrosis without subcutaneous effusion,limb edema and incision infection in a case(3.1%) was found in observation group.Skin flap necrosis in 1 case,subcutaneous effusion in 3 cases and limb edema in 2 cases were found in control group.The complication incidence of observation group(3.1%) was lower than that in control group(20.0%)(P0.05).Conclusions:The nursing intervention in immediate breast reconstruction with keeping NAC can effectively reduce the incidence of postoperative complication,help patient through perioperation and ensure effective treatment.
Objective: To explore the effects of nursing intervention on complication of immediate breast reconstruction with keeping the nipple areola complex(NAC) in the modified radical operation of early breast cancer.Methods:Sixty-two cases with early breast cancer treated with immediate breast reconstruction with keeping NAC in the modified radical operation were divided into control group(30 cases) and observation group(32 cases).The control group were given routine nursing after radical operation,the observation group were given nursing intervention after immediate breast reconstruction in the modified radical operation.The incidence of postoperative complication in two group was compared.Results:Skin flap necrosis without subcutaneous effusion,limb edema and incision infection in a case(3.1%) was found in observation group.Skin flap necrosis in 1 case,subcutaneous effusion in 3 cases and limb edema in 2 cases were found in control group.The complication incidence of observation group(3.1%) was lower than that in control group(20.0%)(P0.05).Conclusions:The nursing intervention in immediate breast reconstruction with keeping NAC can effectively reduce the incidence of postoperative complication,help patient through perioperation and ensure effective treatment.
2013, 37(7): 902-905.
Abstract:
Objective: To investigate the effects of risk assessment and predictive nursing on therapeutic endoscopic retrograde cholangiopancreatography(ERCP) in aged patient.Methods:Routine nursing in 70 aged patients treated with ERCP were implemented from Jan.2010 to Jul.2011 (control group).Risk assessment and predictive nursing in 74 aged patients treated with ERCP were implemented from Aug.2011 to Dec.2012 (experimental group).The ERCP tolerance,success rate of operation and incidence of complications in two groups were compared.Results:There were statistical significances in ERCP tolerance,and the incidence of cholangitis,acute pancreatitis and gastrointestinal hemorrhage between the experimental group and control group(P0.05).There were no statistical significances in the success rate of operation and incidence of perforation in two groups(P0.05).Conclusions:Risk assessment and predictive nursing of therapeutic ERCP in aged patients can effectively improve patient tolerability and significantly reduce the occurrence of postoperative complications.
Objective: To investigate the effects of risk assessment and predictive nursing on therapeutic endoscopic retrograde cholangiopancreatography(ERCP) in aged patient.Methods:Routine nursing in 70 aged patients treated with ERCP were implemented from Jan.2010 to Jul.2011 (control group).Risk assessment and predictive nursing in 74 aged patients treated with ERCP were implemented from Aug.2011 to Dec.2012 (experimental group).The ERCP tolerance,success rate of operation and incidence of complications in two groups were compared.Results:There were statistical significances in ERCP tolerance,and the incidence of cholangitis,acute pancreatitis and gastrointestinal hemorrhage between the experimental group and control group(P0.05).There were no statistical significances in the success rate of operation and incidence of perforation in two groups(P0.05).Conclusions:Risk assessment and predictive nursing of therapeutic ERCP in aged patients can effectively improve patient tolerability and significantly reduce the occurrence of postoperative complications.
2013, 37(7): 905-907.
Abstract:
Objective: To observe the effect of holistic nursing care with responsibility system on acute and chronic complicationsincidence rate of arteriovenous fistula in hemodialysis patients.Methods:Sixty-eight hemodialysis patients with holistic nursing care of responsibility system were randomly extracted as observation group,68 patients with routine care were as control group.The incidence rate of acute and chronic complications in internal arteriovenous fistula and the patient's satisfaction were compared between the two groups.Results:In observation group,the incidence of arteriovenous fistula infection,fistula plug,subcutaneous hematoma and bleeding were lower than that in control group (P0.05),and the degree of satisfaction was higher significantly (P0.01). Conclusions:The holistic nursing care with responsibility system can reduce the incidence of acute and chronic complications in arteriovenous fistula,improve patient satisfaction degree,deepen services connotation,and make the nurse-patient relationship more harmonious.
Objective: To observe the effect of holistic nursing care with responsibility system on acute and chronic complicationsincidence rate of arteriovenous fistula in hemodialysis patients.Methods:Sixty-eight hemodialysis patients with holistic nursing care of responsibility system were randomly extracted as observation group,68 patients with routine care were as control group.The incidence rate of acute and chronic complications in internal arteriovenous fistula and the patient's satisfaction were compared between the two groups.Results:In observation group,the incidence of arteriovenous fistula infection,fistula plug,subcutaneous hematoma and bleeding were lower than that in control group (P0.05),and the degree of satisfaction was higher significantly (P0.01). Conclusions:The holistic nursing care with responsibility system can reduce the incidence of acute and chronic complications in arteriovenous fistula,improve patient satisfaction degree,deepen services connotation,and make the nurse-patient relationship more harmonious.
2013, 37(7): 908-910.
Abstract:
Objective: To investigate the efficacy of the rehabilitation path in nursing neonatal hypoxic-ischemic encephalopathy (HIE).Methods:One hundred and twenty-two neonates with HIE were randomly divided into the control and observation group.The control group were nursed by conventional way until discharge,the treatment group were nursed by rehabilitation path based on the control group during hospitalization and after discharge.The neurobehavior,movement and the index of mental development of two groups were measured in 1,3 and 6 months before and after treatment.Results:The neurobehavior,movement and the index of mental development of two groups were significantly improved in 1,3 and 6 months after treatment (P0.01).Compared with the control group,the neurobehavior,movement and the index of mental development of the observation group showed better improvement in 1, 3 and 6 months after treatment(P0.01).Conclusions:Rehabilitation path nursing can effectively promote the cranial nerves recovery of children with HIE,and play active roles on the recovery of their motion and intelligence development.
Objective: To investigate the efficacy of the rehabilitation path in nursing neonatal hypoxic-ischemic encephalopathy (HIE).Methods:One hundred and twenty-two neonates with HIE were randomly divided into the control and observation group.The control group were nursed by conventional way until discharge,the treatment group were nursed by rehabilitation path based on the control group during hospitalization and after discharge.The neurobehavior,movement and the index of mental development of two groups were measured in 1,3 and 6 months before and after treatment.Results:The neurobehavior,movement and the index of mental development of two groups were significantly improved in 1,3 and 6 months after treatment (P0.01).Compared with the control group,the neurobehavior,movement and the index of mental development of the observation group showed better improvement in 1, 3 and 6 months after treatment(P0.01).Conclusions:Rehabilitation path nursing can effectively promote the cranial nerves recovery of children with HIE,and play active roles on the recovery of their motion and intelligence development.
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