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2014 Vol. 39, No. 7
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2014, 39(7): 841-845.
Abstract:
Objective: To construct the recombination lentiviral expressing vector with human IDO gene.Methods: The full-length coding region fragment of IDO was amplified by primer designed by the cDNA library including IDO gene using polymerase chain reaction(PCR).The target gene was directly inserted into the pGC-FU lentiviral vector,which were transformed into the Bacterium coli DH5α cells.The positive clone was identified by PCR and sequencing.The recombinant lentiviral vector and packaging plasmids phelper 1.0 and pHelper 2.0 were cotransfected into 293T cells.The expression of green fluorescent protein(GFP) was observed to evaluate gene delivery efficiency by fluorescence microscope.The levels of fusion protein IDO-GFP expression were detected by Western Blot,and the titers of lentiviral were determined by Real-time PCR.Results: The encoding sequences of IDO were successfully obtained by the analysis of PCR,the recombination lentiviral vector with human IDO gene was successfully constructed,and transfected into 293T cells to express IDO.The titer of lentivirus was 2×108 TU/ml.Conclusions: The recombinant lentiviral vector with high titer is successfully constructed,which can provide the basis of the future experiment.
Objective: To construct the recombination lentiviral expressing vector with human IDO gene.Methods: The full-length coding region fragment of IDO was amplified by primer designed by the cDNA library including IDO gene using polymerase chain reaction(PCR).The target gene was directly inserted into the pGC-FU lentiviral vector,which were transformed into the Bacterium coli DH5α cells.The positive clone was identified by PCR and sequencing.The recombinant lentiviral vector and packaging plasmids phelper 1.0 and pHelper 2.0 were cotransfected into 293T cells.The expression of green fluorescent protein(GFP) was observed to evaluate gene delivery efficiency by fluorescence microscope.The levels of fusion protein IDO-GFP expression were detected by Western Blot,and the titers of lentiviral were determined by Real-time PCR.Results: The encoding sequences of IDO were successfully obtained by the analysis of PCR,the recombination lentiviral vector with human IDO gene was successfully constructed,and transfected into 293T cells to express IDO.The titer of lentivirus was 2×108 TU/ml.Conclusions: The recombinant lentiviral vector with high titer is successfully constructed,which can provide the basis of the future experiment.
2014, 39(7): 846-848.
Abstract:
Objective: To detect the expression of Galactose lectin 3(Galectin-3) and its relationship with clinicopathological features and human epidermal growth factor receptor-2(Her-2) in breast infiltrating ductal carcinoma.Methods: The expression levels of Galectin-3 and Her-2 in 70 breast infiltrating ductal carcinoma tissue samples were detected by immunohistochemical method.The Her-2 gene expression was detected by fluorescence in situ hybridization.The relationships between the expression of Galectin-3 with the patient age,tumor size,lymph node metastasis,histological grade,clinical stage and Her-2 expression were investigated.Results: The positive rate differences of Galectin-3 expression in different age and tumor size breast cancer tissue had no statistically significant(P>0.05).The positive rate of Galectin-3 expression in sample with lymph node metastasis was higher than that in sample without metastasis(P<0.05).The positive rate differences of Galectin-3 expression in different histological grade and clinical stage had statistically significant(P<0.05).The positive rate of Galectin-3 expression was higher than Her-2 expression in breast cancer tissue(P<0.05).Conclusions: Galectin-3 plays an important role in the occurrence,development,invasion and metastasis of breast cancer.Detecting the expression of Galectin-3 in breast cancer can contribute to judge the malignant degree and prognosis of tumor,which maybe become an important index in guiding clinical treatment.
Objective: To detect the expression of Galactose lectin 3(Galectin-3) and its relationship with clinicopathological features and human epidermal growth factor receptor-2(Her-2) in breast infiltrating ductal carcinoma.Methods: The expression levels of Galectin-3 and Her-2 in 70 breast infiltrating ductal carcinoma tissue samples were detected by immunohistochemical method.The Her-2 gene expression was detected by fluorescence in situ hybridization.The relationships between the expression of Galectin-3 with the patient age,tumor size,lymph node metastasis,histological grade,clinical stage and Her-2 expression were investigated.Results: The positive rate differences of Galectin-3 expression in different age and tumor size breast cancer tissue had no statistically significant(P>0.05).The positive rate of Galectin-3 expression in sample with lymph node metastasis was higher than that in sample without metastasis(P<0.05).The positive rate differences of Galectin-3 expression in different histological grade and clinical stage had statistically significant(P<0.05).The positive rate of Galectin-3 expression was higher than Her-2 expression in breast cancer tissue(P<0.05).Conclusions: Galectin-3 plays an important role in the occurrence,development,invasion and metastasis of breast cancer.Detecting the expression of Galectin-3 in breast cancer can contribute to judge the malignant degree and prognosis of tumor,which maybe become an important index in guiding clinical treatment.
2014, 39(7): 849-851.
Abstract:
Objective: To explore the effects of recombinant human granulocyte-macrophage colony-stimulating factor(rhGM-CSF) on the debridement of deep partial-thickness burn,and its mechanism.Methods: Seventy SD rats with deep partial-thickness burn were established using thermal-water burn(75℃,8 s),and were randomly divided into the experiment group(35 rats) and control group(35 rats).The burn wounds of control group and experiment group were treated with matrix gel and rhGM-CSF gel,respectively.The wounds and dissolving rate of eschar in two groups were analyzed at 1,3,5,7,14 and 21 days after injury.The neutrophils and macrophages infiltration of wounds were observed using immunohistological staining.Results: The dissolving rate of wound eschar in experiment group was significantly higher than that in control group from day 5 to day 10(P<0.01).The inflammatory cells infiltration of wound in experiment group was higher than that in control group from day 3 to 7 day(P<0.01).Conclusions: The rhGM-CSF can promote the inflammatory cells infiltration,debridement and healing of deep partial thickness burn wound.
Objective: To explore the effects of recombinant human granulocyte-macrophage colony-stimulating factor(rhGM-CSF) on the debridement of deep partial-thickness burn,and its mechanism.Methods: Seventy SD rats with deep partial-thickness burn were established using thermal-water burn(75℃,8 s),and were randomly divided into the experiment group(35 rats) and control group(35 rats).The burn wounds of control group and experiment group were treated with matrix gel and rhGM-CSF gel,respectively.The wounds and dissolving rate of eschar in two groups were analyzed at 1,3,5,7,14 and 21 days after injury.The neutrophils and macrophages infiltration of wounds were observed using immunohistological staining.Results: The dissolving rate of wound eschar in experiment group was significantly higher than that in control group from day 5 to day 10(P<0.01).The inflammatory cells infiltration of wound in experiment group was higher than that in control group from day 3 to 7 day(P<0.01).Conclusions: The rhGM-CSF can promote the inflammatory cells infiltration,debridement and healing of deep partial thickness burn wound.
2014, 39(7): 852-854.
Abstract:
Objective: To investigate the relationship between the levels of homocysteine(Hcy) and C-reactive protein(CRP) and macroangiopathy in type 2 diabetes mellitus.Methods: The levels of plasma Hcy and CRP in control group(30 cases),simple diabetes mellitus group(32 cases) and diabetic macroangiopathy group(31 cases) were detected using immunoturbidimetry.The relationship between the levels of Hcy and CRP and diabetic macroangiopathy was analyzed.Results: The levels of plasma Hcy and CRP in simple diabetes mellitus and diabetic macroangiopathy group were significantly higher than those in control group(P<0.01),the levels of plasma Hcy and CRP in simple diabetes mellitus group were significantly lower than those in and diabetic macroangiopathy group(P<0.01).Logistic regression analysis showed that the levels of systolic blood pressure,diastolic blood pressure,HbA1c,triglyceride,total cholesterol,high density lipoprotein,Hcy and CRP were correlated to artherosclerosis.Conclusions: The levels of plasma Hcy and CRP in type 2 diabetic patients with macroangiopathy increased significantly.The treatment with losing body mass,controlling blood glucose,correcting lipid metabolism disorder,increasing insulin sensitivity reducing blood pressure can prevent and delay the occurrence of artherosclerosis.
Objective: To investigate the relationship between the levels of homocysteine(Hcy) and C-reactive protein(CRP) and macroangiopathy in type 2 diabetes mellitus.Methods: The levels of plasma Hcy and CRP in control group(30 cases),simple diabetes mellitus group(32 cases) and diabetic macroangiopathy group(31 cases) were detected using immunoturbidimetry.The relationship between the levels of Hcy and CRP and diabetic macroangiopathy was analyzed.Results: The levels of plasma Hcy and CRP in simple diabetes mellitus and diabetic macroangiopathy group were significantly higher than those in control group(P<0.01),the levels of plasma Hcy and CRP in simple diabetes mellitus group were significantly lower than those in and diabetic macroangiopathy group(P<0.01).Logistic regression analysis showed that the levels of systolic blood pressure,diastolic blood pressure,HbA1c,triglyceride,total cholesterol,high density lipoprotein,Hcy and CRP were correlated to artherosclerosis.Conclusions: The levels of plasma Hcy and CRP in type 2 diabetic patients with macroangiopathy increased significantly.The treatment with losing body mass,controlling blood glucose,correcting lipid metabolism disorder,increasing insulin sensitivity reducing blood pressure can prevent and delay the occurrence of artherosclerosis.
2014, 39(7): 855-857.
Abstract:
Objective: To investigate the clinical and biochemical features of non-obese polycystic ovary syndrome(PCOS) patients.Methods: According to the body mass index(BMI),the 81 patients with PCOS were divided into the non-obese group(BMI<25 kg/m2) and obese group(BMI≥25 kg/m2),the clinical and biochemical features between two groups were compared.Results: The normal menstruation and amenorrhea rates in non-obese group and obese group were 24.49% & 5.9% and 8.5% & 26.5%,respectively,the differences of which were statistical significance(P<0.05).The levels of the follicle stimulating hormone(FSH),luteinizing hormone(LH),ratio of LH to FSH and high density lipoprotein cholesterol in non-obese group were higher than those in obese group(P<0.05 to P<0.01),the levels of the fasting plasma glucose,fasting insulin,total cholesterol,triglyceride and low density lipoprotein in non-obese group were significantly lower than those in obese group(P<0.05 to P<0.01).Conclusions: The non-obese PCOS patients are characterized by the dysfunction of hypothalamus-pituitary gland-ovary axis,the obese PCOS patients are characterized by the dysfunction of metabolism disorder of blood lipid and insulin resistance.The clinical diagnosis and treatment should be individualized.
Objective: To investigate the clinical and biochemical features of non-obese polycystic ovary syndrome(PCOS) patients.Methods: According to the body mass index(BMI),the 81 patients with PCOS were divided into the non-obese group(BMI<25 kg/m2) and obese group(BMI≥25 kg/m2),the clinical and biochemical features between two groups were compared.Results: The normal menstruation and amenorrhea rates in non-obese group and obese group were 24.49% & 5.9% and 8.5% & 26.5%,respectively,the differences of which were statistical significance(P<0.05).The levels of the follicle stimulating hormone(FSH),luteinizing hormone(LH),ratio of LH to FSH and high density lipoprotein cholesterol in non-obese group were higher than those in obese group(P<0.05 to P<0.01),the levels of the fasting plasma glucose,fasting insulin,total cholesterol,triglyceride and low density lipoprotein in non-obese group were significantly lower than those in obese group(P<0.05 to P<0.01).Conclusions: The non-obese PCOS patients are characterized by the dysfunction of hypothalamus-pituitary gland-ovary axis,the obese PCOS patients are characterized by the dysfunction of metabolism disorder of blood lipid and insulin resistance.The clinical diagnosis and treatment should be individualized.
2014, 39(7): 858-860.
Abstract:
Objective: To investigate the expression of E-cadherin(ECD) and its clinical value in predicting the prognosis of laryngeal carcinoma.Methods: The expression of ECD was determined by immunohistochemistry with EnVision two-step method on tissue microarray slides in 79 cases of laryngeal carcinoma tissues;the relationship between the pathological features and the prognosis was analyzed.Results: Negative expression of ECD was detected in 11 cases of the tissue(13.3%);The ECD expression had no statistical differences between the clinical and the pathological features of the patients with the laryngeal carcinoma(P>0.05).The positive rates of ECD were 76.74% and 94.44% in the dead patients and the survival ones respectively;the difference was statistically significant(P<0.05).Conclusions: The ECD expression may be of great value in predicting the prognosis of patients with the laryngeal carcinoma.
Objective: To investigate the expression of E-cadherin(ECD) and its clinical value in predicting the prognosis of laryngeal carcinoma.Methods: The expression of ECD was determined by immunohistochemistry with EnVision two-step method on tissue microarray slides in 79 cases of laryngeal carcinoma tissues;the relationship between the pathological features and the prognosis was analyzed.Results: Negative expression of ECD was detected in 11 cases of the tissue(13.3%);The ECD expression had no statistical differences between the clinical and the pathological features of the patients with the laryngeal carcinoma(P>0.05).The positive rates of ECD were 76.74% and 94.44% in the dead patients and the survival ones respectively;the difference was statistically significant(P<0.05).Conclusions: The ECD expression may be of great value in predicting the prognosis of patients with the laryngeal carcinoma.
2014, 39(7): 861-863.
Abstract:
Objective: To explore the effects of budesonide nebulization inhalation on neonatal ventilator-associated pneumonia(VAP).Methods: Seventy-eight neonates with VAP were randomly divided into the observation group and control group(39 cases each group).The control group were treated with the nebulization inhalation of ambroxol and broad spectrum antibiotics,the observation group were treated with the nebulization inhalation of budesonide based on the routine treatment.The time of moist rales disappearance and chest improvement,the levels of leucocyte and C-reactine protein(CRP),invasive ventilation time and length of hospital stay between two groups were compared.Results: Compared with the control group,the nebulization inhalation of budesonide in treating the neonatal VAP could accelerate the moist rales disappearance,improve the chest,shorten the invasive ventilation time and length of hospital stay(P<0.01 and P<0.05).The levels of leucocyte and CRP at 6 days after treatment were significantly lower than those at 3 days after treatment in two groups(P<0.01),the differences of leucocyte and CRP levels between two groups were not statistically significant(P>0.05).Conclusions: The nebulization inhalation of budesonide can shorten the course of neonatal VAP and improve the curative effects of the conventional therapy.
Objective: To explore the effects of budesonide nebulization inhalation on neonatal ventilator-associated pneumonia(VAP).Methods: Seventy-eight neonates with VAP were randomly divided into the observation group and control group(39 cases each group).The control group were treated with the nebulization inhalation of ambroxol and broad spectrum antibiotics,the observation group were treated with the nebulization inhalation of budesonide based on the routine treatment.The time of moist rales disappearance and chest improvement,the levels of leucocyte and C-reactine protein(CRP),invasive ventilation time and length of hospital stay between two groups were compared.Results: Compared with the control group,the nebulization inhalation of budesonide in treating the neonatal VAP could accelerate the moist rales disappearance,improve the chest,shorten the invasive ventilation time and length of hospital stay(P<0.01 and P<0.05).The levels of leucocyte and CRP at 6 days after treatment were significantly lower than those at 3 days after treatment in two groups(P<0.01),the differences of leucocyte and CRP levels between two groups were not statistically significant(P>0.05).Conclusions: The nebulization inhalation of budesonide can shorten the course of neonatal VAP and improve the curative effects of the conventional therapy.
2014, 39(7): 864-867.
Abstract:
Objective: To analyze the feasibility of hemoglobin A1c(HbA1c) combined with 2 point blood sugar test in the diagnosing of gestational diabetes mellitus(GDM).Methods: The pregnant women with 24 to 28 weeks from the Affiliated Hospital of Guangdong Medical College and Dongguan Houjie Hospital were screened by GDM from Jun 2012 to Feb 2013.The pregnant women with suspected GDM were detected using glucose tolerance test(OGTT) and HbA1c combined with 2 point blood sugar test,respectively.The screening results and clinical significance of two methods were evaluated.Results: Compared with the gold standard,the sensitivity and coincidence rate of 2 points method within 1 to 2 h were higher when OGTT collected blood 2 times(P<0.01).The average levels of HbA1c in 84 patients with suspected GDM(8.73±0.59)% were significantly higher than the normal value(6%)(P<0.01).The differences of HbA1c combined with 2 point blood sugar test test and a single test in the diagnosis of GDM had no statistically significant(P>0.05).The diagnostic sensitivity and specificity of HbA1c combined with 2 point blood sugar test were 87.5% and 84.9%,respectively,and its area under the curve was 0.926(P<0.05).The economic and social benefits of HbA1c combined with 2 point blood sugar test were significantly higher than those of 75 g OGTT test(P<0.01).Conclusions: HbA1c combined with 2 point method can largely reduce the pregnant women pain caused by collecting blood for 4 times,missed diagnosis rate of 2 points method and incidence of pregnancy complications,which can make the GDM patients get the attention and treatment in time.
Objective: To analyze the feasibility of hemoglobin A1c(HbA1c) combined with 2 point blood sugar test in the diagnosing of gestational diabetes mellitus(GDM).Methods: The pregnant women with 24 to 28 weeks from the Affiliated Hospital of Guangdong Medical College and Dongguan Houjie Hospital were screened by GDM from Jun 2012 to Feb 2013.The pregnant women with suspected GDM were detected using glucose tolerance test(OGTT) and HbA1c combined with 2 point blood sugar test,respectively.The screening results and clinical significance of two methods were evaluated.Results: Compared with the gold standard,the sensitivity and coincidence rate of 2 points method within 1 to 2 h were higher when OGTT collected blood 2 times(P<0.01).The average levels of HbA1c in 84 patients with suspected GDM(8.73±0.59)% were significantly higher than the normal value(6%)(P<0.01).The differences of HbA1c combined with 2 point blood sugar test test and a single test in the diagnosis of GDM had no statistically significant(P>0.05).The diagnostic sensitivity and specificity of HbA1c combined with 2 point blood sugar test were 87.5% and 84.9%,respectively,and its area under the curve was 0.926(P<0.05).The economic and social benefits of HbA1c combined with 2 point blood sugar test were significantly higher than those of 75 g OGTT test(P<0.01).Conclusions: HbA1c combined with 2 point method can largely reduce the pregnant women pain caused by collecting blood for 4 times,missed diagnosis rate of 2 points method and incidence of pregnancy complications,which can make the GDM patients get the attention and treatment in time.
2014, 39(7): 867-869.
Abstract:
Objective: To investigate the effects of cervical smear cytology in the screening of cervical cancer.Methods: The clinical data of cervical smear cytology in 5801 women were retrospectively analyzed.The pathology diagnosis of women with abnormal cervical smear cytology and cervical lesions of the different ages subjects were analyzed.Results: Among 5801 patients,cells without heterogeneous nuclear in 2799 cases,cells with mild heterogeneous nuclear in 2914 cases and cells with mild atypical hyperplasia in 88 cases were found.The age of the highest examination abnormal rate was 45 to 55 years old(61/3413,1.79%).Eighty cases with mild atypical hyperplasia,5 cases with severe atypical hyperplasia and 3 cases with cancer cell were found.Among 88 patients with abnormal cervical smear cytology,cervical intraepithelial neoplasia was found in 13 cases.Conclusions: Cervical smear cytology is the preferred method in screening cervical cancer,which can early find cervical precancerous lesions,implement intervention,and reduce the incidence of cervical cancer.
Objective: To investigate the effects of cervical smear cytology in the screening of cervical cancer.Methods: The clinical data of cervical smear cytology in 5801 women were retrospectively analyzed.The pathology diagnosis of women with abnormal cervical smear cytology and cervical lesions of the different ages subjects were analyzed.Results: Among 5801 patients,cells without heterogeneous nuclear in 2799 cases,cells with mild heterogeneous nuclear in 2914 cases and cells with mild atypical hyperplasia in 88 cases were found.The age of the highest examination abnormal rate was 45 to 55 years old(61/3413,1.79%).Eighty cases with mild atypical hyperplasia,5 cases with severe atypical hyperplasia and 3 cases with cancer cell were found.Among 88 patients with abnormal cervical smear cytology,cervical intraepithelial neoplasia was found in 13 cases.Conclusions: Cervical smear cytology is the preferred method in screening cervical cancer,which can early find cervical precancerous lesions,implement intervention,and reduce the incidence of cervical cancer.
2014, 39(7): 870-871,874.
Abstract:
Objective: To investigate the effects of absorbable hemostat(TiSTAT) in transoral endoscopic adenoidectomy.Methods: Eighty adenoid hypertrophy patients treated with transoral endoscopic adenoidectomy were randomly divided into group A(use TiSTAT) and group B(no-use TiSTAT).The intraoperative blood loss,operative time,surgical complications,postoperative recovery and curative effects between two groups were compared.Results: The intraoperative blood loss,operative time and the rate of postoperative rebleeding in group A were significantly less than those in group B(P<0.01).The differences of postoperative recovery and curative effects between two groups were not statistically significant(P>0.05).Conclusions: The application of absorbable hemostat in transoral endoscopic adenoidectomy through mouth is safe and effective,which can decrease blood loss,shorten operative time and reduce postoperative rebleeding and complications.
Objective: To investigate the effects of absorbable hemostat(TiSTAT) in transoral endoscopic adenoidectomy.Methods: Eighty adenoid hypertrophy patients treated with transoral endoscopic adenoidectomy were randomly divided into group A(use TiSTAT) and group B(no-use TiSTAT).The intraoperative blood loss,operative time,surgical complications,postoperative recovery and curative effects between two groups were compared.Results: The intraoperative blood loss,operative time and the rate of postoperative rebleeding in group A were significantly less than those in group B(P<0.01).The differences of postoperative recovery and curative effects between two groups were not statistically significant(P>0.05).Conclusions: The application of absorbable hemostat in transoral endoscopic adenoidectomy through mouth is safe and effective,which can decrease blood loss,shorten operative time and reduce postoperative rebleeding and complications.
2014, 39(7): 872-874.
Abstract:
Objective: To compare the clinical effects of different operation methods in the treatment of late neovascular glaucoma.Methods: Forty-six patients with neovascular glaucoma were randomly divided into A and B groups(23 cases each group).Group A were treated with the ciliary body and peripheral retina condensation technique,group B were treated with the ciliary body and peripheral retina condensation technique combined with trabecular resection of autologous sclera drainage.All cases were followed up for 6 to 12 months.The postoperative intraocular pressure,iris neovascularization,eye shape and complications in two groups were observed.Results: The differences of the control rate of intraocular pressure,fading rate of iris neovascularization and atrophy rate of eyeball between two groups were statistically significant(P<0.05 to P<0.01).Conclusions: The clinical effects of the ciliary body and peripheral retina condensation technique combined with trabecular resection of autologous sclera drainage in the treatment of late neovascular glaucoma are good,which can effectively control the intraocular pressure for a long time,well retain eye appearance,and reduce the postoperative complications.
Objective: To compare the clinical effects of different operation methods in the treatment of late neovascular glaucoma.Methods: Forty-six patients with neovascular glaucoma were randomly divided into A and B groups(23 cases each group).Group A were treated with the ciliary body and peripheral retina condensation technique,group B were treated with the ciliary body and peripheral retina condensation technique combined with trabecular resection of autologous sclera drainage.All cases were followed up for 6 to 12 months.The postoperative intraocular pressure,iris neovascularization,eye shape and complications in two groups were observed.Results: The differences of the control rate of intraocular pressure,fading rate of iris neovascularization and atrophy rate of eyeball between two groups were statistically significant(P<0.05 to P<0.01).Conclusions: The clinical effects of the ciliary body and peripheral retina condensation technique combined with trabecular resection of autologous sclera drainage in the treatment of late neovascular glaucoma are good,which can effectively control the intraocular pressure for a long time,well retain eye appearance,and reduce the postoperative complications.
2014, 39(7): 875-878.
Abstract:
Objective: To explore the curative effects of neoadjuvant chemotherapy on stageⅠb2 to Ⅱb cervical adenocarcinoma.Methods: Forty-four patients with stageⅠb2 to Ⅱb cervical adenocarcinoma were randomly divided into the observation group(24 cases) and control group(20 cases).The control group were treated with radical surgery only,the observation group were treated with the whole uterus and double accessories resection combined with pelvic lymph node dissection after the chemotherapy of paclitaxel combined with cisplatin or nedaplatin for 1 to 2 courses.The tumor change in observation group was observed after chemotherapy.The lymphatic metastasis,intravascular cancer emboli,cervical infiltration,amount of bleeding,operation time and adverse reactions in two groups were compared.Results: The tumor shrank or disappeared after neoadjuvant chemotherapy,the clinical efficiency of which was 70.8%.The operation time of the observation group and control group were(180±30)min and(200±30)min,respectively,the amount of bleeding during operation of the observation group and control group were(400±50)ml and(450±50)ml,respectively.The operation time and amount of bleeding during operation in observation group were less than those in control group(P<0.05 and P<0.01).The occurrence rates of cervical deep stromal infiltration,intravascular cancer emboli and lymphatic metastasis in observation group and control group were 37.5% & 70.0%,25.0% & 55.5% and 12.5% & 40.0%,respectively,these data in observation group were lower than those in control group(P<0.05).The resection rates of vaginal margin in observation group and control group were 0.0% and 15.0 %,respectively,the difference of which was not statistically significant(P>0.05).Conclusions: Neoadjuvant chemotherapy can improve the clinical effects of surgery on stageⅠb2 to Ⅱb cervical adenocarcinoma.
Objective: To explore the curative effects of neoadjuvant chemotherapy on stageⅠb2 to Ⅱb cervical adenocarcinoma.Methods: Forty-four patients with stageⅠb2 to Ⅱb cervical adenocarcinoma were randomly divided into the observation group(24 cases) and control group(20 cases).The control group were treated with radical surgery only,the observation group were treated with the whole uterus and double accessories resection combined with pelvic lymph node dissection after the chemotherapy of paclitaxel combined with cisplatin or nedaplatin for 1 to 2 courses.The tumor change in observation group was observed after chemotherapy.The lymphatic metastasis,intravascular cancer emboli,cervical infiltration,amount of bleeding,operation time and adverse reactions in two groups were compared.Results: The tumor shrank or disappeared after neoadjuvant chemotherapy,the clinical efficiency of which was 70.8%.The operation time of the observation group and control group were(180±30)min and(200±30)min,respectively,the amount of bleeding during operation of the observation group and control group were(400±50)ml and(450±50)ml,respectively.The operation time and amount of bleeding during operation in observation group were less than those in control group(P<0.05 and P<0.01).The occurrence rates of cervical deep stromal infiltration,intravascular cancer emboli and lymphatic metastasis in observation group and control group were 37.5% & 70.0%,25.0% & 55.5% and 12.5% & 40.0%,respectively,these data in observation group were lower than those in control group(P<0.05).The resection rates of vaginal margin in observation group and control group were 0.0% and 15.0 %,respectively,the difference of which was not statistically significant(P>0.05).Conclusions: Neoadjuvant chemotherapy can improve the clinical effects of surgery on stageⅠb2 to Ⅱb cervical adenocarcinoma.
2014, 39(7): 879-883.
Abstract:
Objective: To investigate the expressions of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-2(TIMP-2) in esophageal carcinoma and their relation with the recurrence or metastasis after esophagectomy.Methods: The expressions of MMP-9 and TIMP-2 in patients with ESCC who survived over 5 years without recurrence or metastasis(group A) and those who died of recurrence or metastasis within 1 year(group B) were detected by immunohistochemistry with Tissue Chip technique.Results: There was no expression or little expression of MMP-9 and TIMP-2 in normal esophageal mucosa,but different degrees of expression in esophageal carcinoma.The expression of MMP-9 was significantly higher in patients with lymph node metastasis than in those without(P<0.01);the expression of TIMP-2 was positively correlated with the tumor differentiation and lymph node metastasis(P<0.05);the expression of MMP-9 was not correlated with the expression of TIMP-2(P>0.05).Conclusions: The MMP-9 and TIMP-2 express high in the esophageal carcinoma tissue,and the expression level is significantly correlated with the recurrence or metastasis of the tumor after esophagectomy.Determination of the expression of MMP-9 and TIMP-2 may be of prognostic value in predicting the recurrence or metastasis of the tumor.It is suggested that this detection be included in the routine examination item for the resected specimen to direct the postoperative treatment.
Objective: To investigate the expressions of matrix metalloproteinase-9(MMP-9) and tissue inhibitor of metalloproteinase-2(TIMP-2) in esophageal carcinoma and their relation with the recurrence or metastasis after esophagectomy.Methods: The expressions of MMP-9 and TIMP-2 in patients with ESCC who survived over 5 years without recurrence or metastasis(group A) and those who died of recurrence or metastasis within 1 year(group B) were detected by immunohistochemistry with Tissue Chip technique.Results: There was no expression or little expression of MMP-9 and TIMP-2 in normal esophageal mucosa,but different degrees of expression in esophageal carcinoma.The expression of MMP-9 was significantly higher in patients with lymph node metastasis than in those without(P<0.01);the expression of TIMP-2 was positively correlated with the tumor differentiation and lymph node metastasis(P<0.05);the expression of MMP-9 was not correlated with the expression of TIMP-2(P>0.05).Conclusions: The MMP-9 and TIMP-2 express high in the esophageal carcinoma tissue,and the expression level is significantly correlated with the recurrence or metastasis of the tumor after esophagectomy.Determination of the expression of MMP-9 and TIMP-2 may be of prognostic value in predicting the recurrence or metastasis of the tumor.It is suggested that this detection be included in the routine examination item for the resected specimen to direct the postoperative treatment.
2014, 39(7): 884-885,889.
Abstract:
Objective: To explore the clinical effects of straight incision small bone flap craniotomy in the treatment of hypertensive cerebral hemorrhage.Methods: Forty-four patients with hypertensive cerebral hemorrhage were treated with straight incision small bone flap craniotomy to evacuated the hematoma.The therapeutic effects were evaluated.Results: The hematoma disappearance in 36 cases,a small amount of residual hematoma in 5 cases,half residual hematoma in 2 cases and over half residual hematoma in 1 case were found by brain CT scan within 12 to 48 h after operation.Two cases were operated again because of rebleeding,3 cases gave up treatment and discharged,and 1 case died from pulmonary infection.All patients were followed up for 6 to 12 months,grade Ⅰ in 16 cases,grade Ⅱ in 11 cases,grade Ⅲ in 9 cases and grade Ⅳ in 4 cases were found according the score of activity of daily life.Conclusions: Straight incision small bone flap craniotomy for treating hypertensive cerebral hemorrhage is little trauma,quite hemostasis,less secondary brain impair and good daily capacity recovery,the clinical effect is reliable.
Objective: To explore the clinical effects of straight incision small bone flap craniotomy in the treatment of hypertensive cerebral hemorrhage.Methods: Forty-four patients with hypertensive cerebral hemorrhage were treated with straight incision small bone flap craniotomy to evacuated the hematoma.The therapeutic effects were evaluated.Results: The hematoma disappearance in 36 cases,a small amount of residual hematoma in 5 cases,half residual hematoma in 2 cases and over half residual hematoma in 1 case were found by brain CT scan within 12 to 48 h after operation.Two cases were operated again because of rebleeding,3 cases gave up treatment and discharged,and 1 case died from pulmonary infection.All patients were followed up for 6 to 12 months,grade Ⅰ in 16 cases,grade Ⅱ in 11 cases,grade Ⅲ in 9 cases and grade Ⅳ in 4 cases were found according the score of activity of daily life.Conclusions: Straight incision small bone flap craniotomy for treating hypertensive cerebral hemorrhage is little trauma,quite hemostasis,less secondary brain impair and good daily capacity recovery,the clinical effect is reliable.
2014, 39(7): 886-889.
Abstract:
Objective: To explore the effects of the upper gastrointestinal stenting in the treatment of the benign and malignant esophageal stenosis and(or) tracheal fistula and their complications.Methods: One hundred and twenty-five cases with benign and malignant esophageal stenosis and(or) tracheal fistula were treated with Nitinol stenting implantation.The short-term effects and complications were observed after operation.Results: The symptoms of dysphagia,difficulty in feeding and cough caused by tracheoesophageal fistula were obviously improved.The pain,gastroesophageal reflux,stent displacement and abscission and restenosis of esophagus were the main complications.Conclusions: The upper gastrointestinal stenting is an effective method to treat the benign and malignant esophageal stenosis,the plugging effects on tracheoesophageal fistula are good.The complications can be relieve after treatment.
Objective: To explore the effects of the upper gastrointestinal stenting in the treatment of the benign and malignant esophageal stenosis and(or) tracheal fistula and their complications.Methods: One hundred and twenty-five cases with benign and malignant esophageal stenosis and(or) tracheal fistula were treated with Nitinol stenting implantation.The short-term effects and complications were observed after operation.Results: The symptoms of dysphagia,difficulty in feeding and cough caused by tracheoesophageal fistula were obviously improved.The pain,gastroesophageal reflux,stent displacement and abscission and restenosis of esophagus were the main complications.Conclusions: The upper gastrointestinal stenting is an effective method to treat the benign and malignant esophageal stenosis,the plugging effects on tracheoesophageal fistula are good.The complications can be relieve after treatment.
2014, 39(7): 890-892,896.
Abstract:
Objective: To detect the roles of PTEN and Notch1 in the occurrence and development of colorectal cancer and their mechanisms,and the correlations.Methods: The expressions of PTEN and Notch1 in 60 cases of colorectal cancer tissues and 30 casess of adjacent non-tumor tissues were detected by immunohistochemistry,and their relationships with clinicopathological parameters were analyzed.Results: The positive rate of PTEN expression in colorectal cancer tissue(58.3%) was significantly lower than that in non-tumor tissue(96.7%)(P<0.01),the differences of the differentiation degree,clinical Dukes stage,serosal invasion and lymph node metastasis between them were statistically significant(P<0.05).The positive rate of Notch1 expression in colorectal cancer tissue(45.0%) was significantly higher than that in non-tumor tissue(6.7%)(P<0.05),the differences of the differentiation degree,clinical Dukes stage,serosal invasion and lymph node metastasis between them were statistically significant(P<0.05).The PTEN expression was negatively correlated to the Notch1 expression in colorectal cancer tissue(P<0.05).Conclusions: The dysregulation of PTEN and Notch1 expressions may be associated with the occurrence and development of colorectal cancer.The expression levels of PTEN and Notch1 can provide the theoretical basis in the early diagnosis and treatment of colorectal cancer.
Objective: To detect the roles of PTEN and Notch1 in the occurrence and development of colorectal cancer and their mechanisms,and the correlations.Methods: The expressions of PTEN and Notch1 in 60 cases of colorectal cancer tissues and 30 casess of adjacent non-tumor tissues were detected by immunohistochemistry,and their relationships with clinicopathological parameters were analyzed.Results: The positive rate of PTEN expression in colorectal cancer tissue(58.3%) was significantly lower than that in non-tumor tissue(96.7%)(P<0.01),the differences of the differentiation degree,clinical Dukes stage,serosal invasion and lymph node metastasis between them were statistically significant(P<0.05).The positive rate of Notch1 expression in colorectal cancer tissue(45.0%) was significantly higher than that in non-tumor tissue(6.7%)(P<0.05),the differences of the differentiation degree,clinical Dukes stage,serosal invasion and lymph node metastasis between them were statistically significant(P<0.05).The PTEN expression was negatively correlated to the Notch1 expression in colorectal cancer tissue(P<0.05).Conclusions: The dysregulation of PTEN and Notch1 expressions may be associated with the occurrence and development of colorectal cancer.The expression levels of PTEN and Notch1 can provide the theoretical basis in the early diagnosis and treatment of colorectal cancer.
2014, 39(7): 893-896.
Abstract:
Objective: To investigate the major mutations in patients with papillary thyroid carcinoma at Wannan region of Anhui.Methods: Thirty-three paraffin-embedded samples were collected.After extraction of DNA,the glutamate replaced valine(V600E) of v-raf murine sarcoma viral oncogene homolog B1(BRAF) gene,and the mutations in 12 and 13 codon of K-ras gene were detected using polymerase chain reaction and gene sequencing.Serum total triiodothyronine,free triiodothyronine,total tetraiodothyronine,free tetraiodothyronine and thyroid stimulating hormone of all the cases were measured by luminescentimmunoassay before operation.Results: V600E mutation of BRAF was detected in 13 of the 33 cases(39.4%);Meanwhile,no mutation in 12 and 13 codon of K-ras gene was detected.There was no significant association between V600E mutations of BRAF and the gender,age or diameter of the tumor.The levels of serum triiodothyronine,free triiodothyronine and thyroid stimulating hormone in patients with V600E mutation of BRAF were significantly lower than those in patients without V600E mutation of BRAF(P<0.05 to P<0.01).The levels of serum free tetraiodothyronine in patients with V600E mutation of BRAF were significantly higher than those in patients without V600E mutation of BRAF(P<0.01);the level of serum total tetraiodothyronine had no significant difference between the two groups(P>0.05).Conclusions: V600E mutation of BRAF gene is the major mutation in papillary thyroid carcinoma patients at Wannan region of Anhui
Objective: To investigate the major mutations in patients with papillary thyroid carcinoma at Wannan region of Anhui.Methods: Thirty-three paraffin-embedded samples were collected.After extraction of DNA,the glutamate replaced valine(V600E) of v-raf murine sarcoma viral oncogene homolog B1(BRAF) gene,and the mutations in 12 and 13 codon of K-ras gene were detected using polymerase chain reaction and gene sequencing.Serum total triiodothyronine,free triiodothyronine,total tetraiodothyronine,free tetraiodothyronine and thyroid stimulating hormone of all the cases were measured by luminescentimmunoassay before operation.Results: V600E mutation of BRAF was detected in 13 of the 33 cases(39.4%);Meanwhile,no mutation in 12 and 13 codon of K-ras gene was detected.There was no significant association between V600E mutations of BRAF and the gender,age or diameter of the tumor.The levels of serum triiodothyronine,free triiodothyronine and thyroid stimulating hormone in patients with V600E mutation of BRAF were significantly lower than those in patients without V600E mutation of BRAF(P<0.05 to P<0.01).The levels of serum free tetraiodothyronine in patients with V600E mutation of BRAF were significantly higher than those in patients without V600E mutation of BRAF(P<0.01);the level of serum total tetraiodothyronine had no significant difference between the two groups(P>0.05).Conclusions: V600E mutation of BRAF gene is the major mutation in papillary thyroid carcinoma patients at Wannan region of Anhui
2014, 39(7): 897-899.
Abstract:
Objective: To observe the clinical effects of multi-slice helical CT(MSCT) three-dimensional reconstruction in the minimally invasive extraction of impacted maxillary teeth.Methods: The data of 50 patients with impacted maxillary teeth treated with minimally invasive extraction using the MSCT three dimensional reconstruction guiding(the observation group) were retrospectively analyzed,50 patients with impacted maxillary teeth treated with hammer method were set as the control group.The duration of extraction and the occurrence of intraoperative and postoperative complications between two groups were compared.Results: The operations of two groups were successful.The extraction duration of the observation group and control group were(19.5±5.5) min and(35.5±8.5) min,respectively,the difference of which was statistically significant(P<0.01).The degree of pain and swelling,and incidence of the adjacent teeth damage in observation group were less than those in control group(P<0.05 to P<0.01).Conclusions: The MSCT three dimensional reconstruction can clearly observe the three-dimensional position of impacted teeth in the jaw from different angles and levels,and intuitively and accurately judge the relationship of impacted teeth and surrounding tissue.It can provide the basis for operative accurate approach,reduce the duration,injury and intraoperative and postoperative complications,which is worth further popularizing in clinical use.
Objective: To observe the clinical effects of multi-slice helical CT(MSCT) three-dimensional reconstruction in the minimally invasive extraction of impacted maxillary teeth.Methods: The data of 50 patients with impacted maxillary teeth treated with minimally invasive extraction using the MSCT three dimensional reconstruction guiding(the observation group) were retrospectively analyzed,50 patients with impacted maxillary teeth treated with hammer method were set as the control group.The duration of extraction and the occurrence of intraoperative and postoperative complications between two groups were compared.Results: The operations of two groups were successful.The extraction duration of the observation group and control group were(19.5±5.5) min and(35.5±8.5) min,respectively,the difference of which was statistically significant(P<0.01).The degree of pain and swelling,and incidence of the adjacent teeth damage in observation group were less than those in control group(P<0.05 to P<0.01).Conclusions: The MSCT three dimensional reconstruction can clearly observe the three-dimensional position of impacted teeth in the jaw from different angles and levels,and intuitively and accurately judge the relationship of impacted teeth and surrounding tissue.It can provide the basis for operative accurate approach,reduce the duration,injury and intraoperative and postoperative complications,which is worth further popularizing in clinical use.
2014, 39(7): 900-902.
Abstract:
Objective: To study the characteristics and reasons of recurrent diabetic ketoacidosis(DKA) in Uighur patients with type-2 diabetes in Xinjiang hotan region.Methods: The clinical data of 37 Uighur and 16 Han patients with recurrent DKA in hotan area were analyzed.The patients' age,genders,course of the disease,blood glucose levels,glycosylated hemoglobin A1c(HbAlc) levels,blood pressure,blood total cholesterollevels,triglyceride(TG) levels,high density ripoprotein,low density lipoprotein,blood urea nitrogen(BUN),creatinine,pH,carbon diaxide combining powere(CO2CP),and serum creatine kinase(CK)were collected and analyzed.Results: There were significant differences between the two groups in the course of DKA,HbA1c,TG,BUN,CK,pH and CO2CP(P<0.05 to P<0.01).The recovery time of ketone,pH,insulin dosage every day and the hospital stay of the Uighur diabetes group exceeded those of the Han patients group(P<0.05 to P<0.01).The alimentary control in Uighur diabetes group was poorer than that in Han patients group(P<0.01).Conclusions: The condition of recurrent DKA is more serious in Uighur diabetes patients than in Han patients,and the recovery is slower.The characteristics of recurrent uygur DKA should be considered and the diabetes diet guidance strengthened in hotan area.Only in this way,can the poor control of diabetes in the area be improved.
Objective: To study the characteristics and reasons of recurrent diabetic ketoacidosis(DKA) in Uighur patients with type-2 diabetes in Xinjiang hotan region.Methods: The clinical data of 37 Uighur and 16 Han patients with recurrent DKA in hotan area were analyzed.The patients' age,genders,course of the disease,blood glucose levels,glycosylated hemoglobin A1c(HbAlc) levels,blood pressure,blood total cholesterollevels,triglyceride(TG) levels,high density ripoprotein,low density lipoprotein,blood urea nitrogen(BUN),creatinine,pH,carbon diaxide combining powere(CO2CP),and serum creatine kinase(CK)were collected and analyzed.Results: There were significant differences between the two groups in the course of DKA,HbA1c,TG,BUN,CK,pH and CO2CP(P<0.05 to P<0.01).The recovery time of ketone,pH,insulin dosage every day and the hospital stay of the Uighur diabetes group exceeded those of the Han patients group(P<0.05 to P<0.01).The alimentary control in Uighur diabetes group was poorer than that in Han patients group(P<0.01).Conclusions: The condition of recurrent DKA is more serious in Uighur diabetes patients than in Han patients,and the recovery is slower.The characteristics of recurrent uygur DKA should be considered and the diabetes diet guidance strengthened in hotan area.Only in this way,can the poor control of diabetes in the area be improved.
2014, 39(7): 903-906.
Abstract:
Objective: To investigate the bupivacaine combined with sufentanil application in spinal-epidural anesthesia of the elderly lower limb fracture surgery.Methods: Sixty elderly patients undergone lower limb surgery were randomly divided into bupivacaine group(A group,30 cases) and bupivacaine combined with sufentanil group(B group,30 cases).Group A and B were treated with the 0.5 ml mixture of 7.5 mg bupivacaine and 0.9% sodium chloride,and 0.4 ml mixture of 7.5 mg bupivacaine combined with 5 μg sufentanil and 0.9% sodium chloride,respectively.The onset time,degree and duration time of sensory block,and duration time of motor block,modified Bromage score,and the intraoperative and postoperative itching,nausea and vomiting in two groups were observed.Results: The differences of the onset time of sensory block,modified Bromage score,duration time of motor block and intraoperative and postoperative adverse reactions between two groups were not statistically significant(P>0.05).Compared with A group,the duration time and highest plane of sensory block in B group were significantly prolonged and high(P<0.01).Conclusions: The bupivacaine combined with sufentanil application in spinal-epidural anesthesia of the elderly lower limb fracture surgery is more safe and effective.
Objective: To investigate the bupivacaine combined with sufentanil application in spinal-epidural anesthesia of the elderly lower limb fracture surgery.Methods: Sixty elderly patients undergone lower limb surgery were randomly divided into bupivacaine group(A group,30 cases) and bupivacaine combined with sufentanil group(B group,30 cases).Group A and B were treated with the 0.5 ml mixture of 7.5 mg bupivacaine and 0.9% sodium chloride,and 0.4 ml mixture of 7.5 mg bupivacaine combined with 5 μg sufentanil and 0.9% sodium chloride,respectively.The onset time,degree and duration time of sensory block,and duration time of motor block,modified Bromage score,and the intraoperative and postoperative itching,nausea and vomiting in two groups were observed.Results: The differences of the onset time of sensory block,modified Bromage score,duration time of motor block and intraoperative and postoperative adverse reactions between two groups were not statistically significant(P>0.05).Compared with A group,the duration time and highest plane of sensory block in B group were significantly prolonged and high(P<0.01).Conclusions: The bupivacaine combined with sufentanil application in spinal-epidural anesthesia of the elderly lower limb fracture surgery is more safe and effective.
2014, 39(7): 906-908.
Abstract:
Objective: To investigate the reason,treatment of posterior capsule rapture during phacoemulsification and effects on the vision.Methods: The data of 17 cases with posterior capsule rapture during phacoemulsification were retrospectively analyzed.All cases were divided into group A(11 cases) and group B(6 cases).The posterior capsule rapture of group A and group B occurred during the phacoemulsification,and injection and suction of cortex and intraocular lens implantation,respectively.The visual acuity,intraocular pressure,pupil,location of artificial crystal and fundus between two groups were compared.Results: The differences of corneal edema,anterior chamber reaction and vitreous opacity between two groups were not statistically significant in 1 weeks after operation(P>0.05).The vision acuity in group A was lower than that in group B(P<0.01).The differences of best corrected visual acuity,non-round pupil and incidence of fundus macular edema between two groups were not statistically significant in 3 months after operation(P>0.05).Compared with before operation,the visual acuity of two groups were improved significantly after operation.Conclusions: The timely discovery and treatment of posterior capsule rapture during phacoemulsification can reduce the serious complications,improve the patient's vision and strengthen the confidence of the emulsification beginner.
Objective: To investigate the reason,treatment of posterior capsule rapture during phacoemulsification and effects on the vision.Methods: The data of 17 cases with posterior capsule rapture during phacoemulsification were retrospectively analyzed.All cases were divided into group A(11 cases) and group B(6 cases).The posterior capsule rapture of group A and group B occurred during the phacoemulsification,and injection and suction of cortex and intraocular lens implantation,respectively.The visual acuity,intraocular pressure,pupil,location of artificial crystal and fundus between two groups were compared.Results: The differences of corneal edema,anterior chamber reaction and vitreous opacity between two groups were not statistically significant in 1 weeks after operation(P>0.05).The vision acuity in group A was lower than that in group B(P<0.01).The differences of best corrected visual acuity,non-round pupil and incidence of fundus macular edema between two groups were not statistically significant in 3 months after operation(P>0.05).Compared with before operation,the visual acuity of two groups were improved significantly after operation.Conclusions: The timely discovery and treatment of posterior capsule rapture during phacoemulsification can reduce the serious complications,improve the patient's vision and strengthen the confidence of the emulsification beginner.
2014, 39(7): 909-911.
Abstract:
Objective: To analyze the rationality of vaginal lactobacillus capsule,and provide the basis of the drug use.Methods: The vaginal lactobacillus capsule used in 2 001 prescriptions were classified and analyzed in outpatient patients from January in 2013.Results: The lactobacillus capsule in 633 prescriptions were used alone,and the lactobacillus capsule in 1 368 prescriptions were used in combination with other drugs.The unreasonable prescriptions in 531 cases,unreasonable drug combination in 345 cases and no indication prescriptions in 186 cases were found.Conclusions: The use of lactobacillus capsule combined with topical lotion and oral antibacterial is unreasonable.Scientific and reasonable drug combination can improve curative effect.
Objective: To analyze the rationality of vaginal lactobacillus capsule,and provide the basis of the drug use.Methods: The vaginal lactobacillus capsule used in 2 001 prescriptions were classified and analyzed in outpatient patients from January in 2013.Results: The lactobacillus capsule in 633 prescriptions were used alone,and the lactobacillus capsule in 1 368 prescriptions were used in combination with other drugs.The unreasonable prescriptions in 531 cases,unreasonable drug combination in 345 cases and no indication prescriptions in 186 cases were found.Conclusions: The use of lactobacillus capsule combined with topical lotion and oral antibacterial is unreasonable.Scientific and reasonable drug combination can improve curative effect.
2014, 39(7): 912-914.
Abstract:
Objective: To explore the clinical effects of locking compression plate(LCP) in the treatment of type C distal radius fracture.Methods: Thirty-two patients were treated with open reduction using LCP(steel group,14 cases) and closed reduction external fixation(stent group,18 cases),respectively.Four patients in stent group with uneven articular surface after closed reduction were treated with Kuntscher pin fixation under small incision prying.The external fixator was removed at 8 to 10 weeks after operation according to the fracture healing,and the function of wrist joint was exercised.Results: All cases were followed up for 8 to 24 months.The palm dip angle,ulnar inclination angle between two groups were not statistically sigificant(P>0.05).The differences of the flexion and back stretch degree of wrist jiont,and Gartland-Werley functional score between two groups were statistically sigificant after following up 3 months(P<0.01),but there was no statistical significance after 6 months(P>0.05).Conclusions: Steel plate internal fixation for early recovering wrist activity is better than that of external fixator,but their long-term curative effects are similar.The selecting suitable operation for treating type C distal radius fractures should be according to the specific situation.
Objective: To explore the clinical effects of locking compression plate(LCP) in the treatment of type C distal radius fracture.Methods: Thirty-two patients were treated with open reduction using LCP(steel group,14 cases) and closed reduction external fixation(stent group,18 cases),respectively.Four patients in stent group with uneven articular surface after closed reduction were treated with Kuntscher pin fixation under small incision prying.The external fixator was removed at 8 to 10 weeks after operation according to the fracture healing,and the function of wrist joint was exercised.Results: All cases were followed up for 8 to 24 months.The palm dip angle,ulnar inclination angle between two groups were not statistically sigificant(P>0.05).The differences of the flexion and back stretch degree of wrist jiont,and Gartland-Werley functional score between two groups were statistically sigificant after following up 3 months(P<0.01),but there was no statistical significance after 6 months(P>0.05).Conclusions: Steel plate internal fixation for early recovering wrist activity is better than that of external fixator,but their long-term curative effects are similar.The selecting suitable operation for treating type C distal radius fractures should be according to the specific situation.
2014, 39(7): 915-917.
Abstract:
Objective: To explore the curative effects of nasal endoscopic surgery in the treatment of noninvasive fungal nose-sinusitis.Methods: Sixty-two cases with noninvasive fungal nose-sinusitis cases were diagnosed by CT scanning,and treated with nasal endoscopic surgery combined with antibiotics and 0.9% sodium choride injection flushing.Results: All cases were followed up for 3 months to 2 years and cured.No recurrence and complication were found.Conclusions: The nasal endoscopic surgery combined with antibiotics and 0.9% sodium choride injection flushing is an effective means in treating fungal nose-sinusitis.
Objective: To explore the curative effects of nasal endoscopic surgery in the treatment of noninvasive fungal nose-sinusitis.Methods: Sixty-two cases with noninvasive fungal nose-sinusitis cases were diagnosed by CT scanning,and treated with nasal endoscopic surgery combined with antibiotics and 0.9% sodium choride injection flushing.Results: All cases were followed up for 3 months to 2 years and cured.No recurrence and complication were found.Conclusions: The nasal endoscopic surgery combined with antibiotics and 0.9% sodium choride injection flushing is an effective means in treating fungal nose-sinusitis.
2014, 39(7): 917-919.
Abstract:
Objective: To investigate the clinical effects of the high speed turbine drilling gap in the treatment of mandibular impacted wisdom teeth.Methods: Eighty-two cases with impacted wisdom teeth were divided into experimental group(52 cases) and control group(30 cases).The experimental group and control group were treated with high speed turbine drill method and traditional bone chisel in extraction method,respectively.The operation time,postoperative trismus,pain and alveolalgia between two groups were compared.Results: Compared with the control group,the operation time,postoperative trismus and pain in experimental group were short,light and less,respectively(P<0.01).Three cases with alveolalgia in control group and no alveolalgia in experimental group were found,the difference of which was not statistically significant(P>0.05).Conclusions: The postoperative complications of high speed turbine drill in the extraction of impacted wisdom teeth is less and light,which can be applied for various clinical types of impacted teeth.
Objective: To investigate the clinical effects of the high speed turbine drilling gap in the treatment of mandibular impacted wisdom teeth.Methods: Eighty-two cases with impacted wisdom teeth were divided into experimental group(52 cases) and control group(30 cases).The experimental group and control group were treated with high speed turbine drill method and traditional bone chisel in extraction method,respectively.The operation time,postoperative trismus,pain and alveolalgia between two groups were compared.Results: Compared with the control group,the operation time,postoperative trismus and pain in experimental group were short,light and less,respectively(P<0.01).Three cases with alveolalgia in control group and no alveolalgia in experimental group were found,the difference of which was not statistically significant(P>0.05).Conclusions: The postoperative complications of high speed turbine drill in the extraction of impacted wisdom teeth is less and light,which can be applied for various clinical types of impacted teeth.
2014, 39(7): 920-923.
Abstract:
Objective: To explore the influence of different doses of dezocine on anesthesia tracheal extubation reaction and postoperative agitation of patients receiving gastric cancer surgery.Methods: Eighty ASA ⅠorⅡ patients undergoing elective gastric cancer surgery were randomly divided into four groups,with 20 cases in each one.The four groups were respectively given 0.05 mg/kg of intravenous dezocine(group D1),0.1 mg/kg of intravenous dezocine(group D2),0.2 mg/kg of intravenous dezocine(group D3) and 0.9% sodium chloride injection 2 ml(group N) 20 minutes before the end of the surgery.The MAP,HR,RR and SpO2 were observed and recorded before the induction(T0),the time of sputum suction before extubation(T1),immediately after extubation(T2),and 5 min(T3) and 10 min(T4) after extubation.The postoperative recovery time of spontaneous breathing and awakening,the extubation time,the tube drawing quality score and the postoperative agitation score(RS) were also recorded.The pain degree was assessed with verbal rating scale(VRS) 5 minutes after revival from general anesthesia.Results: Compared with T0,the MAP rose obviously at T1-T3 in group D1,at T1-T2 in group D2,at T1 in group D3 and at T1-T4 in group N(P<0.05 to P<0.01);the HR rose obviously at T1-T4 in group D1 and group N,at T1 and T3 in group D2 and group D3(P<0.01);compared with group N,the MAP decreased obviously at T1-T2 in group D2 and at T1-T4 in group D3(P<0.05 to P<0.01);HR slowed significantly at T1 and T3 in group D2,and at T1-T4 in group D3(P<0.05 to P<0.01).The recovery time of spontaneous breathing,awakening and the extubation time was obviously lengthened in group D3(P<0.01);there were no statistically significant differences among group D1,D2 and group N(P<0.05).The tube drawing quality score of group D1,D2 and D3 was superior to that of group N(P<0.01),and group D2 was better than group D1(P<0.01);The postoperative agitation score of group D2 was superior to that of group D1 and group N(P<0.01).The VRS score of group D1,D2 and D3 was superior to that of group N 5 min after extubation(P<0.01),and group D2 and D3 had higher score than group D1(P<0.05).Conclusions: Different doses of dezocine can reduce the tracheal extubation reaction of patients with general anesthesia.And 0.1 mg/kg dezocine may effectively inhibit the anesthesia tracheal extubation reaction and postoperative agitation,but has no significant influence on the recovery time of spontaneous breathing or awakening.
Objective: To explore the influence of different doses of dezocine on anesthesia tracheal extubation reaction and postoperative agitation of patients receiving gastric cancer surgery.Methods: Eighty ASA ⅠorⅡ patients undergoing elective gastric cancer surgery were randomly divided into four groups,with 20 cases in each one.The four groups were respectively given 0.05 mg/kg of intravenous dezocine(group D1),0.1 mg/kg of intravenous dezocine(group D2),0.2 mg/kg of intravenous dezocine(group D3) and 0.9% sodium chloride injection 2 ml(group N) 20 minutes before the end of the surgery.The MAP,HR,RR and SpO2 were observed and recorded before the induction(T0),the time of sputum suction before extubation(T1),immediately after extubation(T2),and 5 min(T3) and 10 min(T4) after extubation.The postoperative recovery time of spontaneous breathing and awakening,the extubation time,the tube drawing quality score and the postoperative agitation score(RS) were also recorded.The pain degree was assessed with verbal rating scale(VRS) 5 minutes after revival from general anesthesia.Results: Compared with T0,the MAP rose obviously at T1-T3 in group D1,at T1-T2 in group D2,at T1 in group D3 and at T1-T4 in group N(P<0.05 to P<0.01);the HR rose obviously at T1-T4 in group D1 and group N,at T1 and T3 in group D2 and group D3(P<0.01);compared with group N,the MAP decreased obviously at T1-T2 in group D2 and at T1-T4 in group D3(P<0.05 to P<0.01);HR slowed significantly at T1 and T3 in group D2,and at T1-T4 in group D3(P<0.05 to P<0.01).The recovery time of spontaneous breathing,awakening and the extubation time was obviously lengthened in group D3(P<0.01);there were no statistically significant differences among group D1,D2 and group N(P<0.05).The tube drawing quality score of group D1,D2 and D3 was superior to that of group N(P<0.01),and group D2 was better than group D1(P<0.01);The postoperative agitation score of group D2 was superior to that of group D1 and group N(P<0.01).The VRS score of group D1,D2 and D3 was superior to that of group N 5 min after extubation(P<0.01),and group D2 and D3 had higher score than group D1(P<0.05).Conclusions: Different doses of dezocine can reduce the tracheal extubation reaction of patients with general anesthesia.And 0.1 mg/kg dezocine may effectively inhibit the anesthesia tracheal extubation reaction and postoperative agitation,but has no significant influence on the recovery time of spontaneous breathing or awakening.
2014, 39(7): 924-926.
Abstract:
Objective: To compare the curative effects of radiofrequency ablation(RFA) combined with percutaneous vertebroplasty(PVP) and percutaneous kyphoplasty(PKP) in the treatment of multi-segmental thoracic and lumbar spinal metastases.Methods: One hundred and twelve patients with segmental metastases complicated with thoracolumbar vertebral compression fractures were randomly divided into the PVP group(58 cases,83 vertebras) and PKP group(54 cases,75 vertebras),the PVP and PKP group were treated with PVP and PKP,respectively.The pain degrees in two groups were evaulated using verbal rating scale before treatment and at 1 day after treatment.The vertebral height recovery,bone cement leakage,bleeding and hemopneumothorax in two groups were recorded after the surgery.The curative effects between two goups were compared after treatment.Results: The vertebral punctures in 112 patients were successful,all cases were followed up for 12 to 24 months.The difference of visual analoglle scales scores before surgery in two groups was not statistically signficant(P>0.05),the difference of visual analoglle scales scores of two groups between before surgery and at 1 day after surgery was statistically signficant(P<0.05).The heights of anterior vertebral body in PVP group and PKP group at 1 year after surgery rose to(79.85±4.21)% and(95.23±2.05)% of the normal average height,respectively,the difference of which was statistically signficant(P<0.05).The bone cement leakage in PVP group 22 cases(35 vertebras)and in PKP group 13 cases(16 vertebras).No bleeding case in two groups was found.Conclusions: The radiofrequency ablation combined with PVP and PKP for treating multi-segmental thoracic lumbar spinal metastases is good effects and less complications.The reduction effects of PKP are better than that of PVP,the PKP treatment is less leakage of bone cement.Treatment choice should be according to patients condition.
Objective: To compare the curative effects of radiofrequency ablation(RFA) combined with percutaneous vertebroplasty(PVP) and percutaneous kyphoplasty(PKP) in the treatment of multi-segmental thoracic and lumbar spinal metastases.Methods: One hundred and twelve patients with segmental metastases complicated with thoracolumbar vertebral compression fractures were randomly divided into the PVP group(58 cases,83 vertebras) and PKP group(54 cases,75 vertebras),the PVP and PKP group were treated with PVP and PKP,respectively.The pain degrees in two groups were evaulated using verbal rating scale before treatment and at 1 day after treatment.The vertebral height recovery,bone cement leakage,bleeding and hemopneumothorax in two groups were recorded after the surgery.The curative effects between two goups were compared after treatment.Results: The vertebral punctures in 112 patients were successful,all cases were followed up for 12 to 24 months.The difference of visual analoglle scales scores before surgery in two groups was not statistically signficant(P>0.05),the difference of visual analoglle scales scores of two groups between before surgery and at 1 day after surgery was statistically signficant(P<0.05).The heights of anterior vertebral body in PVP group and PKP group at 1 year after surgery rose to(79.85±4.21)% and(95.23±2.05)% of the normal average height,respectively,the difference of which was statistically signficant(P<0.05).The bone cement leakage in PVP group 22 cases(35 vertebras)and in PKP group 13 cases(16 vertebras).No bleeding case in two groups was found.Conclusions: The radiofrequency ablation combined with PVP and PKP for treating multi-segmental thoracic lumbar spinal metastases is good effects and less complications.The reduction effects of PKP are better than that of PVP,the PKP treatment is less leakage of bone cement.Treatment choice should be according to patients condition.
2014, 39(7): 927-929.
Abstract:
Objective: To compare the effects of the combined spinal-epidural anesthesia(CSEA) and continuous epidural anesthesia(CEA) on cesarean section in scar uterine.Methods: Sixty-six elective caesarean patients with scar uterine were randomly divided into the CSEA group(33 cases) and CEA group(33 cases).The anaesthetic effects,adverse reaction and effect of hemodynamics of parturient on neonate in two groups were observed.Results: Compared with before anesthesia,the noninvasive arteries pressure levels in CSEA group and CEA group were decreased significantly at 10 min and 20 min after anesthesia,respectively(P<0.01).The levels of heart rate in CSEA group and CEA group were increased significantly at 10 to 30 min and 20 to 30 min after anesthesia,respectively(P<0.01).The dosage,onset time and retardation time of anesthesia in CSEA group were significantly lower than those in CEA group(P<0.01).The excellence ratio of anesthesia in CSEA group(100.0%) was higher than that in CEA group(84.9%)(P<0.05).Conclusions: The CSEA has the dual advantages of CEA and lumbar anesthesia,which has good effect on cesarean section in scar uterine.
Objective: To compare the effects of the combined spinal-epidural anesthesia(CSEA) and continuous epidural anesthesia(CEA) on cesarean section in scar uterine.Methods: Sixty-six elective caesarean patients with scar uterine were randomly divided into the CSEA group(33 cases) and CEA group(33 cases).The anaesthetic effects,adverse reaction and effect of hemodynamics of parturient on neonate in two groups were observed.Results: Compared with before anesthesia,the noninvasive arteries pressure levels in CSEA group and CEA group were decreased significantly at 10 min and 20 min after anesthesia,respectively(P<0.01).The levels of heart rate in CSEA group and CEA group were increased significantly at 10 to 30 min and 20 to 30 min after anesthesia,respectively(P<0.01).The dosage,onset time and retardation time of anesthesia in CSEA group were significantly lower than those in CEA group(P<0.01).The excellence ratio of anesthesia in CSEA group(100.0%) was higher than that in CEA group(84.9%)(P<0.05).Conclusions: The CSEA has the dual advantages of CEA and lumbar anesthesia,which has good effect on cesarean section in scar uterine.
2014, 39(7): 930-931,934.
Abstract:
Objective: To explore the clinical effects of the hip deep fascia flap under the wound inside combined with continuous pressure suction under flap in repairing the pressure sores of sacrococcygeal region.Methods: Twelve cases with pressure sores of sacrococcygeal region were repaired with the hip deep fascia flap under the wound inside combined with continuous pressure suction under flap,the area of flap was 6 cm×5 cm to 13 cm×7 cm.Results: All flaps were survived,the primary healing of incision in 10 cases and delayed healing of incision in 2 cases were found.All cases recovered well after the operation.Conclusions: The hip deep fascia flap under the wound inside combined with continuous pressure suction under flap in repairing the pressure sores of sacrococcygeal region is simple,good and easy to master.
Objective: To explore the clinical effects of the hip deep fascia flap under the wound inside combined with continuous pressure suction under flap in repairing the pressure sores of sacrococcygeal region.Methods: Twelve cases with pressure sores of sacrococcygeal region were repaired with the hip deep fascia flap under the wound inside combined with continuous pressure suction under flap,the area of flap was 6 cm×5 cm to 13 cm×7 cm.Results: All flaps were survived,the primary healing of incision in 10 cases and delayed healing of incision in 2 cases were found.All cases recovered well after the operation.Conclusions: The hip deep fascia flap under the wound inside combined with continuous pressure suction under flap in repairing the pressure sores of sacrococcygeal region is simple,good and easy to master.
2014, 39(7): 932-934.
Abstract:
Objective: To explore the expression of cardiac enzymes and cardiac troponin I(cTnI) in neonatal hyperbilirubinemia.Methods: Eighty neonates with hyperbilirubinemia and 80 neonates with physiological jaundice were divided into the hyperbilirubinemia group and control group.The serum levels of cTnI,creatine kinase,creatine kinase-MB,aspartate aminotransferase and in two groups were measured.Results: The positive rates of cTnI and creatine kinase-MB in hyperbilirubinemia group were 70.0% and 46.3%,respectively,the difference of which was statistically significant(P<0.01).The total bilirubin level was positively correlated with cTnI in hyperbilirubinemia group(P<0.01).Conclusions: High bilirubin can lead to a reversible myocardial injury.The expression of cTnI is stable,which can be used as a criteria in early diagnosis and treatment of myocardial injury.
Objective: To explore the expression of cardiac enzymes and cardiac troponin I(cTnI) in neonatal hyperbilirubinemia.Methods: Eighty neonates with hyperbilirubinemia and 80 neonates with physiological jaundice were divided into the hyperbilirubinemia group and control group.The serum levels of cTnI,creatine kinase,creatine kinase-MB,aspartate aminotransferase and in two groups were measured.Results: The positive rates of cTnI and creatine kinase-MB in hyperbilirubinemia group were 70.0% and 46.3%,respectively,the difference of which was statistically significant(P<0.01).The total bilirubin level was positively correlated with cTnI in hyperbilirubinemia group(P<0.01).Conclusions: High bilirubin can lead to a reversible myocardial injury.The expression of cTnI is stable,which can be used as a criteria in early diagnosis and treatment of myocardial injury.
2014, 39(7): 935-936,939.
Abstract:
Objective: To explore the preventive effects of new chest belt on subcutaneous effusion of breast cancer after operation.Methods: One hundred and seventeen breast cancer patients treated with radical resection were randomly divided into observation group(61 cases) and control group(56 cases).The incisions of the observation group and control group were banded using new chest belt and multiple chest belt,respectively.Under the condition of high and low tension flap,the subcutaneous effusion between two groups were compared.Results: Under the condition of low tension flap,the subcutaneous effusion rate of observation group was lower than that of control group(P<0.05).Under the condition of high tension flap,there was not significant difference in the subcutaneous effusion rate between two groups(P>0.05).Conclusions: New chest belt can effectively reduce the subcutaneous effusion rate of breast cancer with low tension flap after operation.The prevention effect of subcutaneous effusion in patients with high tension flap need to improve.
Objective: To explore the preventive effects of new chest belt on subcutaneous effusion of breast cancer after operation.Methods: One hundred and seventeen breast cancer patients treated with radical resection were randomly divided into observation group(61 cases) and control group(56 cases).The incisions of the observation group and control group were banded using new chest belt and multiple chest belt,respectively.Under the condition of high and low tension flap,the subcutaneous effusion between two groups were compared.Results: Under the condition of low tension flap,the subcutaneous effusion rate of observation group was lower than that of control group(P<0.05).Under the condition of high tension flap,there was not significant difference in the subcutaneous effusion rate between two groups(P>0.05).Conclusions: New chest belt can effectively reduce the subcutaneous effusion rate of breast cancer with low tension flap after operation.The prevention effect of subcutaneous effusion in patients with high tension flap need to improve.
2014, 39(7): 951-953.
Abstract:
Objective: To explore the value of color Doppler ultrasound in the diagnosis of carotid atherosclerosis of patients with cerebral infarction.Methods: The medial membrane thickness of carotid artery and plaque formation in 123 cases with cerebral infarction and 90 healthy people were analyzed.Results: The detection rates of carotid atherosclerosis plaque formation and pure intima thickening in the patients with cerebral infarction were 63.4% and 21.9%,respectively,the detection rate of plaque formation in more than 55 years old patients was significantly higher than that in less than 55 years old patients(P<0.05).The detection rates of carotid atherosclerosis plaque formation and pure intima thickening in healthy people were 6.7% and 11.1%,respectively.The detection rate of carotid atherosclerosis in patients with cerebral infarction was higher than that in healthy people(P<0.01).The detection rates of carotid atherosclerosis plaque formation in patients with cerebral infarction complicated with hypertension,diabetes and above two kinds of diseases were 72.6%,60.0% and 84.4%,respectively,which was significantly higher than that in cerebral infarction patients without hypertension and diabetes(P<0.01).Conclusions: Color Doppler ultrasound examination can early detect the carotid atherosclerosis in patients with cerebral infarction,which is a noninvasive and valuable method.The less than 55 years old of patient is a critical period.
Objective: To explore the value of color Doppler ultrasound in the diagnosis of carotid atherosclerosis of patients with cerebral infarction.Methods: The medial membrane thickness of carotid artery and plaque formation in 123 cases with cerebral infarction and 90 healthy people were analyzed.Results: The detection rates of carotid atherosclerosis plaque formation and pure intima thickening in the patients with cerebral infarction were 63.4% and 21.9%,respectively,the detection rate of plaque formation in more than 55 years old patients was significantly higher than that in less than 55 years old patients(P<0.05).The detection rates of carotid atherosclerosis plaque formation and pure intima thickening in healthy people were 6.7% and 11.1%,respectively.The detection rate of carotid atherosclerosis in patients with cerebral infarction was higher than that in healthy people(P<0.01).The detection rates of carotid atherosclerosis plaque formation in patients with cerebral infarction complicated with hypertension,diabetes and above two kinds of diseases were 72.6%,60.0% and 84.4%,respectively,which was significantly higher than that in cerebral infarction patients without hypertension and diabetes(P<0.01).Conclusions: Color Doppler ultrasound examination can early detect the carotid atherosclerosis in patients with cerebral infarction,which is a noninvasive and valuable method.The less than 55 years old of patient is a critical period.
2014, 39(7): 956-959.
Abstract:
Objective: To investigate the relationships among the levels of plasma homocysteine(Hcy),N-terminal prohormone of brainnatriuretic(NT-proBNP),high sensitivity C reactive protein(hs-CRP) and ischemic stroke(IS) onset and recurrence,and provide the scientific basis for clinical diagnosis,condition assessment and prognosis.Methods: Total 216 patients with IS from Dec.2011 to Aug.2013 were recruited,134 cases with IS initial onset,and 82 cases with recurrence,meanwhile 100 healthy persons were selected as control group.Plasma Hcy,NT-proBNP and hs-CRP levels in the three groups were measured.The factors in IS initial onset and recurrence were carried out in multiple logistic regression analysis.Results: The plasma Hcy,NT-proBNP and hs-CRP levels in primary and recurrent IS patients were significantly higher than that in control group(P<0.01);Hcy,NT-proBNP and hs-CRP levels in the recurrence group were significantly higher than that in the initial onset group(P<0.01);Hcy,NT-proBNP and hs-CRP levels in recurrent group accounted for 56.10%,38.06% and 74.39% above the normal range,which were significantly higher than 38.06%,26.87% and 36.57% in primary group(P<0.01);the multiple logistic regression analysis results displayed the rise of Hcy,NT-proBNP and hs-CRP levels were IS independent risk factors for the inifial onset(P<0.01);diabetes and the rise of Hcy,NT-proBNP and hs-CRP levels were the independent risk factors for the recurrence of IS(P<0.01).Conclusions: Plasma Hcy,NT-proBNP,hs-CRP levels in IS patients are significantly higher than in healthy people,and Hcy,NT-proBNP,hs-CRP levels in the recurrence IS are also higher than in the initial onset.High levels of Hcy,NT-proBNP and hs-CRP are all IS independent risk factors for recurrence.
Objective: To investigate the relationships among the levels of plasma homocysteine(Hcy),N-terminal prohormone of brainnatriuretic(NT-proBNP),high sensitivity C reactive protein(hs-CRP) and ischemic stroke(IS) onset and recurrence,and provide the scientific basis for clinical diagnosis,condition assessment and prognosis.Methods: Total 216 patients with IS from Dec.2011 to Aug.2013 were recruited,134 cases with IS initial onset,and 82 cases with recurrence,meanwhile 100 healthy persons were selected as control group.Plasma Hcy,NT-proBNP and hs-CRP levels in the three groups were measured.The factors in IS initial onset and recurrence were carried out in multiple logistic regression analysis.Results: The plasma Hcy,NT-proBNP and hs-CRP levels in primary and recurrent IS patients were significantly higher than that in control group(P<0.01);Hcy,NT-proBNP and hs-CRP levels in the recurrence group were significantly higher than that in the initial onset group(P<0.01);Hcy,NT-proBNP and hs-CRP levels in recurrent group accounted for 56.10%,38.06% and 74.39% above the normal range,which were significantly higher than 38.06%,26.87% and 36.57% in primary group(P<0.01);the multiple logistic regression analysis results displayed the rise of Hcy,NT-proBNP and hs-CRP levels were IS independent risk factors for the inifial onset(P<0.01);diabetes and the rise of Hcy,NT-proBNP and hs-CRP levels were the independent risk factors for the recurrence of IS(P<0.01).Conclusions: Plasma Hcy,NT-proBNP,hs-CRP levels in IS patients are significantly higher than in healthy people,and Hcy,NT-proBNP,hs-CRP levels in the recurrence IS are also higher than in the initial onset.High levels of Hcy,NT-proBNP and hs-CRP are all IS independent risk factors for recurrence.
2014, 39(7): 970-972.
Abstract:
Objective: To investigate the psychological characteristics and nursing intervention of pregnant women with threatened premature labor.Methods: Sixty-nine pregnant women with threatened premature labor were treated with inhibiting uterine contraction and strengthening the fetal monitoring and psychological nursing of pregnant women.Results: The stress,anxiety,enhancing dependency,95.65% of anticipatory grief and despair and 4.35% of holding escapism psychological denial were found in 69 pregnant women with threatened premature labor.Except 2 cases giving up the treatment of preventing miscarriage,the pregnant weeks of the remaining patients were prolonged.Conclusions: Strengthening the fetal monitoring and psychological nursing of pregnant women can significantly improve the health of mother and child and increase the fetal survival.
Objective: To investigate the psychological characteristics and nursing intervention of pregnant women with threatened premature labor.Methods: Sixty-nine pregnant women with threatened premature labor were treated with inhibiting uterine contraction and strengthening the fetal monitoring and psychological nursing of pregnant women.Results: The stress,anxiety,enhancing dependency,95.65% of anticipatory grief and despair and 4.35% of holding escapism psychological denial were found in 69 pregnant women with threatened premature labor.Except 2 cases giving up the treatment of preventing miscarriage,the pregnant weeks of the remaining patients were prolonged.Conclusions: Strengthening the fetal monitoring and psychological nursing of pregnant women can significantly improve the health of mother and child and increase the fetal survival.
2014, 39(7): 973-976.
Abstract:
Objective: To explore the effects of self-efficacy and self-care intervention on the quality of life of postoperative patients with laryngocarcinoma.Methods: Seventy-nine patients with laryngocarcinoma diagnosed by pathology from the E.N.T.department of a top three hospital were divided into the observation and control group.The control group and observation group were nursed with routine nursing and self-efficacy and self-care on the basis of the routine nursing,respectively.The intervention effects were evaluated using the General Self-Efficacy Scale,the exercise of Self-care Agency and the Chinese quality of life instrument for cancer patients-head and neck cancer.Results: The ability of self-efficacy and self-care and quality of life of patients in observation group increased,which were better than those in control group(P<0.01).The scores of self-efficacy and self-care ability in observation group were improved as time went on(P<0.01),The differences of the scores of quality of life in patients between the preoperation,discharge and after the intervention were statistically significant(P<0.05 to P<0.01).Conclusions: The joint nursing intervention can significantly improve the ability of self-efficacy and self-care and quality of life of patients with laryngocarcinoma.
Objective: To explore the effects of self-efficacy and self-care intervention on the quality of life of postoperative patients with laryngocarcinoma.Methods: Seventy-nine patients with laryngocarcinoma diagnosed by pathology from the E.N.T.department of a top three hospital were divided into the observation and control group.The control group and observation group were nursed with routine nursing and self-efficacy and self-care on the basis of the routine nursing,respectively.The intervention effects were evaluated using the General Self-Efficacy Scale,the exercise of Self-care Agency and the Chinese quality of life instrument for cancer patients-head and neck cancer.Results: The ability of self-efficacy and self-care and quality of life of patients in observation group increased,which were better than those in control group(P<0.01).The scores of self-efficacy and self-care ability in observation group were improved as time went on(P<0.01),The differences of the scores of quality of life in patients between the preoperation,discharge and after the intervention were statistically significant(P<0.05 to P<0.01).Conclusions: The joint nursing intervention can significantly improve the ability of self-efficacy and self-care and quality of life of patients with laryngocarcinoma.
2014, 39(7): 977-979.
Abstract:
Objective: To investigate the effects of daily wake-up strategy on multiple trauma patients receiving postoperative sedation and analgesia.Methods: Thirty-six patients with multiple traumas were analyzed retrospectively.All the cases who were transferred to ICU after operation and received mechanical ventilation and sustained implementation of fentanyl and midazolam were divided into wake-up group(n=18) and control group(n=18).The patients in the wake-up group were applied daily wake-up strategy and special care interventions,while the control group received only the routine treatment and care.The dosage of sedative and analgesic drugs,the duration of mechanical ventilation,the length of ICU stay and the hospital cost were compared between the two groups.Results: The differences were statistically significant(P<0.05 to P<0.01) in the wake-up group and the control group in the dosage of sedative and analgesic drugs,duration of mechanical ventilation,length of ICU stay and hospital costs.Conclusions: The daily wake-up strategy combined with proper nursing care may not only reduce the dosage of sedative and analgesic drugs,shorten the length of mechanical ventilation and ICU stay but decrease the hospital cost for the multiple trauma patients receiving postoperative sedation and analgesia.
Objective: To investigate the effects of daily wake-up strategy on multiple trauma patients receiving postoperative sedation and analgesia.Methods: Thirty-six patients with multiple traumas were analyzed retrospectively.All the cases who were transferred to ICU after operation and received mechanical ventilation and sustained implementation of fentanyl and midazolam were divided into wake-up group(n=18) and control group(n=18).The patients in the wake-up group were applied daily wake-up strategy and special care interventions,while the control group received only the routine treatment and care.The dosage of sedative and analgesic drugs,the duration of mechanical ventilation,the length of ICU stay and the hospital cost were compared between the two groups.Results: The differences were statistically significant(P<0.05 to P<0.01) in the wake-up group and the control group in the dosage of sedative and analgesic drugs,duration of mechanical ventilation,length of ICU stay and hospital costs.Conclusions: The daily wake-up strategy combined with proper nursing care may not only reduce the dosage of sedative and analgesic drugs,shorten the length of mechanical ventilation and ICU stay but decrease the hospital cost for the multiple trauma patients receiving postoperative sedation and analgesia.
2014, 39(7): 980-982.
Abstract:
Objective: To investigate the application effects of the pre-hospital emergency care for the patients with thoracoabdominal injury in primary hospital.Methods: Nighty-six patients with thoracoabdominal injury from June 2011 to June 2013 and 56 patients with thoracoabdominal injury before June 2011 were divided into the observation group and control group,respectively.The control group were treated with conventional care,and the observation group were treated with the procedural and standardized pre-hospital emergency care.The preparation time in hospital,the success and death rate of rescuing and patient satisfaction between two groups were compared.Results: The preparation time in hospital in observation group was significantly shorter than that in control group(P<0.01).The success rate of rescuing and patient satisfaction in observation group(92.7% and 95.9%) were higher than those in control group(80.4% and 82.1%)((P<0.05 and P<0.01),respectively.The death rate of rescuing in observation group(7.3%) was significantly less than that in control group(19.6%)(P<0.05).Conclusions: The effects of the procedural and standardized pre-hospital emergency care for the patients with thoracoabdominal injury in primary hospital are good,which can improve the success rate and patient satisfaction.
Objective: To investigate the application effects of the pre-hospital emergency care for the patients with thoracoabdominal injury in primary hospital.Methods: Nighty-six patients with thoracoabdominal injury from June 2011 to June 2013 and 56 patients with thoracoabdominal injury before June 2011 were divided into the observation group and control group,respectively.The control group were treated with conventional care,and the observation group were treated with the procedural and standardized pre-hospital emergency care.The preparation time in hospital,the success and death rate of rescuing and patient satisfaction between two groups were compared.Results: The preparation time in hospital in observation group was significantly shorter than that in control group(P<0.01).The success rate of rescuing and patient satisfaction in observation group(92.7% and 95.9%) were higher than those in control group(80.4% and 82.1%)((P<0.05 and P<0.01),respectively.The death rate of rescuing in observation group(7.3%) was significantly less than that in control group(19.6%)(P<0.05).Conclusions: The effects of the procedural and standardized pre-hospital emergency care for the patients with thoracoabdominal injury in primary hospital are good,which can improve the success rate and patient satisfaction.
2014, 39(7): 983-985.
Abstract:
Objective: To evaluate the best time of rehabilitated catheter for patients who used the patient-controlled intravenous analgesia pump after the surgery of the lower limb.Methods: The data of 180 patients were randomly selected who received the surgery of the lower limb from March 2012 to April 2013.According to the time of rehabilitated catheter,they were divided into 4 groups.The 45 cases in group Ⅰ were rehabilitated catheter in 12 hours after the surgery.The 45 cases in group Ⅱ were rehabilitated catheter in 24 hours after the surgery.The 45 cases in group Ⅲ were rehabilitated catheter in 48 hours after the surgery at the end of analgesia.The 45 cases in group Ⅳ were rehabilitated catheter in 48 hours after the surgery at the time of analgesia end and the bladder filling.The group Ⅰ and Ⅱ were not clipped the catheter before rehabilitation,and informed the importance of timely rehabilitation.The group Ⅲ and Ⅳ were clipped intermittently.They were opened when the patients have to urinate.Observing the situation of the 4 groups' urination and the positive urinary leukocyte.Results: In group Ⅰ,the positive voiding rate of the patients were significantly lower than those in group Ⅱ,Ⅲ and Ⅳ(P<0.01);the positive rate of urinary leukocyte of the patients in group Ⅲ and Ⅳ group was 20.00% and 20.22%,was higher than those in group Ⅰ and Ⅱ(P<0.05).Conclusions: To patients who used the patient-controlled intravenous analgesia pump after the surgery of the lower limb,the best time to rehabilitate catheter is 24 hours after surgery.
Objective: To evaluate the best time of rehabilitated catheter for patients who used the patient-controlled intravenous analgesia pump after the surgery of the lower limb.Methods: The data of 180 patients were randomly selected who received the surgery of the lower limb from March 2012 to April 2013.According to the time of rehabilitated catheter,they were divided into 4 groups.The 45 cases in group Ⅰ were rehabilitated catheter in 12 hours after the surgery.The 45 cases in group Ⅱ were rehabilitated catheter in 24 hours after the surgery.The 45 cases in group Ⅲ were rehabilitated catheter in 48 hours after the surgery at the end of analgesia.The 45 cases in group Ⅳ were rehabilitated catheter in 48 hours after the surgery at the time of analgesia end and the bladder filling.The group Ⅰ and Ⅱ were not clipped the catheter before rehabilitation,and informed the importance of timely rehabilitation.The group Ⅲ and Ⅳ were clipped intermittently.They were opened when the patients have to urinate.Observing the situation of the 4 groups' urination and the positive urinary leukocyte.Results: In group Ⅰ,the positive voiding rate of the patients were significantly lower than those in group Ⅱ,Ⅲ and Ⅳ(P<0.01);the positive rate of urinary leukocyte of the patients in group Ⅲ and Ⅳ group was 20.00% and 20.22%,was higher than those in group Ⅰ and Ⅱ(P<0.05).Conclusions: To patients who used the patient-controlled intravenous analgesia pump after the surgery of the lower limb,the best time to rehabilitate catheter is 24 hours after surgery.
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