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2014 Vol. 39, No. 8
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2014, 39(8): 997-1000.
Abstract:
Objective: To investigate the protective effects of tetramethylpyrazine(TMP) on the acute lung injury induced(ALI) by lipopolysaccharide(LPS) in rats.Methods: All rats were randomly into the control group,LPS group,TMP Ⅰ group(injected with 40 mg/kg) and TMP Ⅱ group(injected with 80 mg/kg)(6 rats each group).The twenty-four ALI model Wistar rats were established by injecting 1 mg/kg of LPS into abdominal cavity,and dripping 3 mg/kg of LPS into trachea after 16 hours.The rats were sacrificed,fixed with 4% paraformaldehyde and treated with pathology at 3 hours after treatment with tetramethylpyrazine.The wet/dry weight ratio of lung and levels of MPO and MDA in lung tissues were measured.The protein expressions of RhoA and ROCK2,and mRNA expression of ROCK2 in lung tissues were detected using western-blot and RT-PCR,respectively.Results: Compared with the control group,the pathological section showed that the pulmonary interstitial edema,alveolar cavity bleeding,inflammatory cells exudate,wet/dry weight ratio of lung,MPO activity and MDA content increased significantly in LPS group(P<0.01),the protein expressions of RhoA and ROCK2,and mRNA expression of ROCK2 were also increased in LPS group(P<0.01).The wet/dry weight ratio of lung,MPO activity,MDA content and indexes of RhoA and ROCK2 in TMP Ⅰ group and TMP Ⅱ group were significantly less than those in LPS group(P<0.05 to P<0.01),but their differences between TMPⅠ group and TMP Ⅱ group were not statistical significance(P>0.05).Conclusions: Tetramethylpyrazine can protect against the acute lung injury induced by LPS in rats.
Objective: To investigate the protective effects of tetramethylpyrazine(TMP) on the acute lung injury induced(ALI) by lipopolysaccharide(LPS) in rats.Methods: All rats were randomly into the control group,LPS group,TMP Ⅰ group(injected with 40 mg/kg) and TMP Ⅱ group(injected with 80 mg/kg)(6 rats each group).The twenty-four ALI model Wistar rats were established by injecting 1 mg/kg of LPS into abdominal cavity,and dripping 3 mg/kg of LPS into trachea after 16 hours.The rats were sacrificed,fixed with 4% paraformaldehyde and treated with pathology at 3 hours after treatment with tetramethylpyrazine.The wet/dry weight ratio of lung and levels of MPO and MDA in lung tissues were measured.The protein expressions of RhoA and ROCK2,and mRNA expression of ROCK2 in lung tissues were detected using western-blot and RT-PCR,respectively.Results: Compared with the control group,the pathological section showed that the pulmonary interstitial edema,alveolar cavity bleeding,inflammatory cells exudate,wet/dry weight ratio of lung,MPO activity and MDA content increased significantly in LPS group(P<0.01),the protein expressions of RhoA and ROCK2,and mRNA expression of ROCK2 were also increased in LPS group(P<0.01).The wet/dry weight ratio of lung,MPO activity,MDA content and indexes of RhoA and ROCK2 in TMP Ⅰ group and TMP Ⅱ group were significantly less than those in LPS group(P<0.05 to P<0.01),but their differences between TMPⅠ group and TMP Ⅱ group were not statistical significance(P>0.05).Conclusions: Tetramethylpyrazine can protect against the acute lung injury induced by LPS in rats.
2014, 39(8): 1001-1005.
Abstract:
Objective: To explore the role of docosahexaenoic acid(DHA) in atrial fibrillation rat,and its effects on the expression of TWIK-Related K+ Channel 1(TREK-1).Methods: Sprague-Dawley(SD) rats sensitive to acetylcholine-calcium chloride mixture were randomly divided into the control group(group A),DHA treatment control group(group B),atrial fibrillation(group C) and DHA treatment atrial fibrillation group(group D).The duration of atrial fibrillation and atrial effective refractory period(ERP) were observed.The expressions of TREK-1 protein and mRNA in atrial muscle of rats were detected using Western blot and reverse transcriptase-polymerase chain reaction.Results: Compared with group C,the occurrence and duration time of atrial fibrillation in group D were significantly delayed and shorten,respectively(P<0.01).Compared with group A and D,the atrial ERP in group C was significantly shorten(P<0.01).Compared with group A and D,the expressions of TREK-1 mRNA and protein in group C increased significantly(P<0.01).Conclusions: DHA may play the role of anti-atrial fibrillation,the mechanism of which may be related to the expression downregulation of TREK-1.
Objective: To explore the role of docosahexaenoic acid(DHA) in atrial fibrillation rat,and its effects on the expression of TWIK-Related K+ Channel 1(TREK-1).Methods: Sprague-Dawley(SD) rats sensitive to acetylcholine-calcium chloride mixture were randomly divided into the control group(group A),DHA treatment control group(group B),atrial fibrillation(group C) and DHA treatment atrial fibrillation group(group D).The duration of atrial fibrillation and atrial effective refractory period(ERP) were observed.The expressions of TREK-1 protein and mRNA in atrial muscle of rats were detected using Western blot and reverse transcriptase-polymerase chain reaction.Results: Compared with group C,the occurrence and duration time of atrial fibrillation in group D were significantly delayed and shorten,respectively(P<0.01).Compared with group A and D,the atrial ERP in group C was significantly shorten(P<0.01).Compared with group A and D,the expressions of TREK-1 mRNA and protein in group C increased significantly(P<0.01).Conclusions: DHA may play the role of anti-atrial fibrillation,the mechanism of which may be related to the expression downregulation of TREK-1.
2014, 39(8): 1005-1007,1011.
Abstract:
Objective: To detect the expressions of CD133,cancer stem cells marker,and extracellular signal-regulated protein kinase 1(ERK1) in papillary thyroid carcinoma(PTC),and their correlations and clinicopathological significance.Methods: The expressions of CD133 and ERK1 in 68 samples of PTC tissue and 40 samples of nodular goiter tissue were detected by immunohistochemistry.Results: The positive rates of CD133 and ERK1 in PTC and nodular goiter tissues were 10.0% & 50.0% and 12.5% & 63.2%,respectively,the differences of which were statistically significant(P<0.01).The differences of the expression levels of CD133 in tumor grade,lymph node metastasis and TNM stage of PTC were statistically significant(P<0.05 to P<0.01).With the PTC worsening differentiation,lymph node transferring and clinical stage increasing,the positive rates of ERK1 increased(P<0.01).There was a positive correlation between the expression of CD133 and ERK1(P<0.05).Conclusions: The abnormal expressions of CD133 and ERK1 may be involved in the occurrence,development,invasion and metastasis of PTC.The early combination examination of CD133 and ERK1 has a certain clinical significance in the progression and prognosis of PTC.
Objective: To detect the expressions of CD133,cancer stem cells marker,and extracellular signal-regulated protein kinase 1(ERK1) in papillary thyroid carcinoma(PTC),and their correlations and clinicopathological significance.Methods: The expressions of CD133 and ERK1 in 68 samples of PTC tissue and 40 samples of nodular goiter tissue were detected by immunohistochemistry.Results: The positive rates of CD133 and ERK1 in PTC and nodular goiter tissues were 10.0% & 50.0% and 12.5% & 63.2%,respectively,the differences of which were statistically significant(P<0.01).The differences of the expression levels of CD133 in tumor grade,lymph node metastasis and TNM stage of PTC were statistically significant(P<0.05 to P<0.01).With the PTC worsening differentiation,lymph node transferring and clinical stage increasing,the positive rates of ERK1 increased(P<0.01).There was a positive correlation between the expression of CD133 and ERK1(P<0.05).Conclusions: The abnormal expressions of CD133 and ERK1 may be involved in the occurrence,development,invasion and metastasis of PTC.The early combination examination of CD133 and ERK1 has a certain clinical significance in the progression and prognosis of PTC.
2014, 39(8): 1008-1011.
Abstract:
Objective: To explore the inhibition effects of NK-92 cells on the Her-2 gene expression in SKOV-3 cells in vitro and in vivo.Methods: The SKOV-3/siRNA cell line with persistent silencing the Her2 gene expression were established by the siRNA targeting Her2 gene transfecting into SKOV-3 cell line.The inhibition effects on Her2 gene mRNA expression were detected by RT-PCR and immunohistochemistry.The killing activity of NK-92 cells to SKOV-3 and SKOV-3/siRNA was detected by LDH.The tumor growth in the nude mice inoculated with SKOV-3 and SKOV-3/siRNA subcutaneously was observed.The effects of NK-92 cells on ovarian cancer in all cases were compared.Results: The SKOV-3/siRNA cell line with persistent silencing the Her2 gene expression was established,the Her2 gene expression was strong inhibited.The killing rates of NK-92 cells to SKOV-3 and SKOV-3/siRNA were(21.1±6.8)% and(45.5±8.9)% at 1：20 of the target ratio,respectively(P<0.01).The tumor volume in mice inoculated with SKOV-3/siRN cells was significantly less than that in mice inoculated with ASKOV-3(P<0.05 to P<0.01),The tumor quality in mice treated with SKOV-3/siRN combined with NK-92 cells were significantly less than that in other mice(P<0.05 to P<0.01).Conclusions: NK-92 cells combined with siRNA targeting Her2 gene can inhibit the proliferation of the ovarian cancer cell line SKOV-3 in vitro and in vivo,which may become a new approach of ovarian cancer therapy.
Objective: To explore the inhibition effects of NK-92 cells on the Her-2 gene expression in SKOV-3 cells in vitro and in vivo.Methods: The SKOV-3/siRNA cell line with persistent silencing the Her2 gene expression were established by the siRNA targeting Her2 gene transfecting into SKOV-3 cell line.The inhibition effects on Her2 gene mRNA expression were detected by RT-PCR and immunohistochemistry.The killing activity of NK-92 cells to SKOV-3 and SKOV-3/siRNA was detected by LDH.The tumor growth in the nude mice inoculated with SKOV-3 and SKOV-3/siRNA subcutaneously was observed.The effects of NK-92 cells on ovarian cancer in all cases were compared.Results: The SKOV-3/siRNA cell line with persistent silencing the Her2 gene expression was established,the Her2 gene expression was strong inhibited.The killing rates of NK-92 cells to SKOV-3 and SKOV-3/siRNA were(21.1±6.8)% and(45.5±8.9)% at 1：20 of the target ratio,respectively(P<0.01).The tumor volume in mice inoculated with SKOV-3/siRN cells was significantly less than that in mice inoculated with ASKOV-3(P<0.05 to P<0.01),The tumor quality in mice treated with SKOV-3/siRN combined with NK-92 cells were significantly less than that in other mice(P<0.05 to P<0.01).Conclusions: NK-92 cells combined with siRNA targeting Her2 gene can inhibit the proliferation of the ovarian cancer cell line SKOV-3 in vitro and in vivo,which may become a new approach of ovarian cancer therapy.
2014, 39(8): 1012-1014.
Abstract:
Objective: To explore the clinical significance of the level changes of serum Des-γ-carboxy-prothrombin(DCP) and α-fetoprotein(AFP) before and after transcatheter arterial chemoembolization(TACE) in patients with primary hepatic carcinoma(PHC).Methods: The serum levels of DCP and AFP in patients with HPC before TACE,and in 1,2 and 4 months after TACE were detected by ELISA.Ninety-five PHC patients treated with TACE were divided into the improvement group and progression group according to their clinical effects.The relationships between DCP and AFP dynamic changes before and after TACE and TACE treatment effect were analysed.Results: Compared with the preoperation,the serum DCP levels in 2 and 4 months after operation and AFP level in 4 months after operation in improvement group decreased(P<0.01),but in progression group,their levels increased(P<0.05).Compared with the preoperation,the serum DCP levels in PHC patients of progression group with less than 400 ng/ml of AFP incrased in 1,2 and 4 months after operation(P<0.05),and the difference of AFP level was not statistical significance(P>0.05).Conclusions: The serum DCP and AFP level in PHC patients can be acted as the index in judging the curative effect of TACE.The DCP has more advantage than AFP in judging the curative effect of TACE while the serum AFP level is low.
Objective: To explore the clinical significance of the level changes of serum Des-γ-carboxy-prothrombin(DCP) and α-fetoprotein(AFP) before and after transcatheter arterial chemoembolization(TACE) in patients with primary hepatic carcinoma(PHC).Methods: The serum levels of DCP and AFP in patients with HPC before TACE,and in 1,2 and 4 months after TACE were detected by ELISA.Ninety-five PHC patients treated with TACE were divided into the improvement group and progression group according to their clinical effects.The relationships between DCP and AFP dynamic changes before and after TACE and TACE treatment effect were analysed.Results: Compared with the preoperation,the serum DCP levels in 2 and 4 months after operation and AFP level in 4 months after operation in improvement group decreased(P<0.01),but in progression group,their levels increased(P<0.05).Compared with the preoperation,the serum DCP levels in PHC patients of progression group with less than 400 ng/ml of AFP incrased in 1,2 and 4 months after operation(P<0.05),and the difference of AFP level was not statistical significance(P>0.05).Conclusions: The serum DCP and AFP level in PHC patients can be acted as the index in judging the curative effect of TACE.The DCP has more advantage than AFP in judging the curative effect of TACE while the serum AFP level is low.
2014, 39(8): 1015-1017.
Abstract:
Objective: To summarize the experience in diagnosis and treatment of carotid body tumors(CBT) and explore the preoperative preparation,operation methods and prevention of the complications.Methods: Twenty-one patients with CBT were performed ultrasonography examination before surgical operation;8 cases received digital subtraction radiography and 13 multi-slice spiral CT angiography or magnetic resonance angiography.All the 21 cases underwent Matas test before operation;10 patients received resection of the tumor only,7 cases resection of the tumor along with the external carotid artery,4 cases vascular reconstruction of the carotid artery after resection of the tumor body,carotid artery,external carotid artery and the common carotid artery.Results: Complete resection of the CBT was achieved in all the 21 cases.No death,paralysis or blindness occurred after surgery.Distortion of commissure was observed in 1 case,Horner's syndrome in 1 case,hoarseness in 1 case,crooked tongue in 1 case and bucking while drinking in 1 cases.Twenty patients were followed up for a period of 4 months to 15 years,with no tumor recurrence or metastases.Conclusions: Preoperative color Dopple,selective angiography and multi-slice spiral CT angiography or magnetic resonance angiograph may help to confirm the diagnosis;surgical resection is the choice of treatment for carotid body tumor.Diminishing the cerebral ischemia time and protecting the cerebral nerve are essential for the prevention of serious postoperative complications.
Objective: To summarize the experience in diagnosis and treatment of carotid body tumors(CBT) and explore the preoperative preparation,operation methods and prevention of the complications.Methods: Twenty-one patients with CBT were performed ultrasonography examination before surgical operation;8 cases received digital subtraction radiography and 13 multi-slice spiral CT angiography or magnetic resonance angiography.All the 21 cases underwent Matas test before operation;10 patients received resection of the tumor only,7 cases resection of the tumor along with the external carotid artery,4 cases vascular reconstruction of the carotid artery after resection of the tumor body,carotid artery,external carotid artery and the common carotid artery.Results: Complete resection of the CBT was achieved in all the 21 cases.No death,paralysis or blindness occurred after surgery.Distortion of commissure was observed in 1 case,Horner's syndrome in 1 case,hoarseness in 1 case,crooked tongue in 1 case and bucking while drinking in 1 cases.Twenty patients were followed up for a period of 4 months to 15 years,with no tumor recurrence or metastases.Conclusions: Preoperative color Dopple,selective angiography and multi-slice spiral CT angiography or magnetic resonance angiograph may help to confirm the diagnosis;surgical resection is the choice of treatment for carotid body tumor.Diminishing the cerebral ischemia time and protecting the cerebral nerve are essential for the prevention of serious postoperative complications.
2014, 39(8): 1018-1020,1023.
Abstract:
Objective: To investigate the distribution of pathogenic bacteria and its drug sensitivity of chronic suppurative otitis media,and guide clinical rational drug use.Methods: The data of the pus cultivation and drug sensitivity test of chronic suppurative otitis media in 156 patients were retrospectively analyzed.Results: One hundred and twenty-seven strains pathogenic bacteria were detected in 156 specimens,which included 119 strains of bacteria and 8 strains of fungi.The four leading bacteria were coagulase negative staphylococcus(41 strains,32.23%),pseudomonas aeruginosa(19 strains,15.0%),staphylococcus aureus(18 strains,14.2%) and proteus(11 cases,8.7%).Different pathogenic bacteria had different drug sensitivities.Conclusions: The coagulase negative staphylococcus,pseudomonas aeruginosa,staphylococcus aureus and proteus are the major pathogenic bacteria in chronic suppurative otitis media.The reasonable choice of antibiotics should base on the drug sensitive test.
Objective: To investigate the distribution of pathogenic bacteria and its drug sensitivity of chronic suppurative otitis media,and guide clinical rational drug use.Methods: The data of the pus cultivation and drug sensitivity test of chronic suppurative otitis media in 156 patients were retrospectively analyzed.Results: One hundred and twenty-seven strains pathogenic bacteria were detected in 156 specimens,which included 119 strains of bacteria and 8 strains of fungi.The four leading bacteria were coagulase negative staphylococcus(41 strains,32.23%),pseudomonas aeruginosa(19 strains,15.0%),staphylococcus aureus(18 strains,14.2%) and proteus(11 cases,8.7%).Different pathogenic bacteria had different drug sensitivities.Conclusions: The coagulase negative staphylococcus,pseudomonas aeruginosa,staphylococcus aureus and proteus are the major pathogenic bacteria in chronic suppurative otitis media.The reasonable choice of antibiotics should base on the drug sensitive test.
2014, 39(8): 1021-1023.
Abstract:
Objective: To investigate the clinical effects of modified laparoscopic assisted vaginal hysterectomy(LAVH) in the treatment of adenomyosis.Methods: Fifty-three patients with adenomyosis after invalid conservative treatment were selected.Twenty-two patients were treated with modified LAVH,21 cases were treated with vaginal hysterectomy(TVH).Results: The attachment operation and endometriosis lesions burning operation were implemented in the patients treated with modified LAVH.The differences of hospitalization expenses and postoperative anal exhaust time between the patients treated with modified LAVH and TVH were statistically significant(P<0.01).The differences of operation time,intraoperative bleeding and hospitalization time between the patients treated with modified LAVH and TVH were not statistically significant(P>0.05).Conclusions: The modified LAVH is a better means in hysterectomy of patients with adenomyosis.
Objective: To investigate the clinical effects of modified laparoscopic assisted vaginal hysterectomy(LAVH) in the treatment of adenomyosis.Methods: Fifty-three patients with adenomyosis after invalid conservative treatment were selected.Twenty-two patients were treated with modified LAVH,21 cases were treated with vaginal hysterectomy(TVH).Results: The attachment operation and endometriosis lesions burning operation were implemented in the patients treated with modified LAVH.The differences of hospitalization expenses and postoperative anal exhaust time between the patients treated with modified LAVH and TVH were statistically significant(P<0.01).The differences of operation time,intraoperative bleeding and hospitalization time between the patients treated with modified LAVH and TVH were not statistically significant(P>0.05).Conclusions: The modified LAVH is a better means in hysterectomy of patients with adenomyosis.
2014, 39(8): 1024-1025.
Abstract:
Objective: To investigate the clinical application of LigaSure vessel sealing system(LVSS) combined with crushing clamp method in hepatolobectomy.Methods: The hepatic artery and vein and less than level 3 branch of portal vein were treated with LVSS and crushing clamp method,the branches of left hepatic vein and middle hepatic vein were treated with 5-0 Proline line ligature combined with LVSS.Results: The time of operation was 127-230 min,the volume of bleeding was 150-500 ml,and the average time of hospitalization stay was 8 to 14 days.No intra-abdominal hemorrhage,bile leakage and death after operation were found.Conclusions: LVSS combined with crushing clamp method in hepatolobectomy was a safe and reliable means.
Objective: To investigate the clinical application of LigaSure vessel sealing system(LVSS) combined with crushing clamp method in hepatolobectomy.Methods: The hepatic artery and vein and less than level 3 branch of portal vein were treated with LVSS and crushing clamp method,the branches of left hepatic vein and middle hepatic vein were treated with 5-0 Proline line ligature combined with LVSS.Results: The time of operation was 127-230 min,the volume of bleeding was 150-500 ml,and the average time of hospitalization stay was 8 to 14 days.No intra-abdominal hemorrhage,bile leakage and death after operation were found.Conclusions: LVSS combined with crushing clamp method in hepatolobectomy was a safe and reliable means.
2014, 39(8): 1026-1027,1030.
Abstract:
Objective: To explore the clinical characteristics and individualized treatment effects of acute myelocytic leukemia(AML) in elderly patients.Methods: The clinical characteristics of 67 initial treatment elderly patients with AML were analyzed.The patients were treated with the combination with the standard doses or substandard doses of DA,AA,HA and CAG or the single chemotherapy with harringtonine or Ara-C.Results: The total complete remission(CR) rate was 50.7 %.The CR rate of 26 cases with 60 to 69 years old was 60.5%,which included 18 cases(69.2%) with better physical condition(the median survival time was 15.5 months,early death was 1 case) and 8 cases(47.1%) with poor physical condition(the median survival time was 10.3 months,early death was 3 cases).The CR rate of 8 cases with more than 70 years old was 33.3%(their median survival time was 7.5 months,early death was 7 cases).Different degrees of bone marrow suppression in all patients were found.Conclusions: The elderly people with acute myelocytic leukemia are large difference in chemotherapy responses,low CR rate,short survival time and high death rate.The individualized treatment can improve the CR.
Objective: To explore the clinical characteristics and individualized treatment effects of acute myelocytic leukemia(AML) in elderly patients.Methods: The clinical characteristics of 67 initial treatment elderly patients with AML were analyzed.The patients were treated with the combination with the standard doses or substandard doses of DA,AA,HA and CAG or the single chemotherapy with harringtonine or Ara-C.Results: The total complete remission(CR) rate was 50.7 %.The CR rate of 26 cases with 60 to 69 years old was 60.5%,which included 18 cases(69.2%) with better physical condition(the median survival time was 15.5 months,early death was 1 case) and 8 cases(47.1%) with poor physical condition(the median survival time was 10.3 months,early death was 3 cases).The CR rate of 8 cases with more than 70 years old was 33.3%(their median survival time was 7.5 months,early death was 7 cases).Different degrees of bone marrow suppression in all patients were found.Conclusions: The elderly people with acute myelocytic leukemia are large difference in chemotherapy responses,low CR rate,short survival time and high death rate.The individualized treatment can improve the CR.
2014, 39(8): 1028-1030.
Abstract:
Objective: To explore the clinical effects of postoperative chemoradiation and radiotherapy on advanced hypopharyngeal carcinoma.Methods: Thirty-seven patients with advanced hypopharyngeal carcinoma(including 20 cases with laryngeal function and 17 cases without laryngeal function) were treated with radiotherapy after surgery(radiotherapy group),35 patients with advanced hypopharyngeal carcinoma(including 24 cases with laryngeal function and 11 cases without laryngeal function) were treated with chemoradiation after surgery(chemoradiation group).The survival rate and life quality of two groups were compared,and the survival rate of patients with and without laryngeal function was compared.Results: The 3-year and 5-year survival rates in radiotherapy group and chemoradiation group were 48.65% & 71.43% and 24.32% & 48.57%,respectively,the difference of which was statistically significant(P<0.05).The differences of the incidence rates of toxicity and pharyngeal fistula,and the swallowing function and linguistic function recovery in two groups were not statistically significant(P>0.05).The 3-year and 5-year survival rates in patients with and without without laryngeal function were 40.90% & 60.71% and 27.27% & 39.28%,respectively,the difference of which was not statistically significant(P>0.05).Conclusions: The survival rates of 3-and 5-year of patients with advanced hypopharyngeal carcinoma treated with chemoradiation are higher than those of patients treated only with radiotherapy,the treatment does not increase the toxicity and affect the life quality of postoperative patients.The survival rates of 3-and 5-year of patients with and without laryngeal function are similar,and the laryngeal function can be preserved according to the disease.
Objective: To explore the clinical effects of postoperative chemoradiation and radiotherapy on advanced hypopharyngeal carcinoma.Methods: Thirty-seven patients with advanced hypopharyngeal carcinoma(including 20 cases with laryngeal function and 17 cases without laryngeal function) were treated with radiotherapy after surgery(radiotherapy group),35 patients with advanced hypopharyngeal carcinoma(including 24 cases with laryngeal function and 11 cases without laryngeal function) were treated with chemoradiation after surgery(chemoradiation group).The survival rate and life quality of two groups were compared,and the survival rate of patients with and without laryngeal function was compared.Results: The 3-year and 5-year survival rates in radiotherapy group and chemoradiation group were 48.65% & 71.43% and 24.32% & 48.57%,respectively,the difference of which was statistically significant(P<0.05).The differences of the incidence rates of toxicity and pharyngeal fistula,and the swallowing function and linguistic function recovery in two groups were not statistically significant(P>0.05).The 3-year and 5-year survival rates in patients with and without without laryngeal function were 40.90% & 60.71% and 27.27% & 39.28%,respectively,the difference of which was not statistically significant(P>0.05).Conclusions: The survival rates of 3-and 5-year of patients with advanced hypopharyngeal carcinoma treated with chemoradiation are higher than those of patients treated only with radiotherapy,the treatment does not increase the toxicity and affect the life quality of postoperative patients.The survival rates of 3-and 5-year of patients with and without laryngeal function are similar,and the laryngeal function can be preserved according to the disease.
2014, 39(8): 1031-1033,1036.
Abstract:
Objective: To investigate the clinical efficacy of rectal mucosa columnar ligation injection combined with anal tightening operation in the treatment of rectal prolapse.Methods: Thirty patients with rectal prolapse were treated with rectal mucosa columnar ligation injection combined with anal tightening operation,the curative effects were observed.Results: Among 30 patients with rectal prolapse,29 cases cured,and 1 case improved,the cure rate of which was 96.67%(29/30).The differences of the levels of WBC,RBC,Hb and PLT in all csase before and after operation were not statistically significant(P>0.05).The neutrophils level at 1 day after operation was significantly higher than that in before operation and postoperative 5 days(P<0.01),the difference of neutrophils level between before operation and postoperative 5 days was not statistically significant(P>0.05).Conclusions: The clinical curative effects of rectal mucosa columnar ligation injection combined with anal tightening operation on treating rectal prolapse is good,which is worthy of clinical application.
Objective: To investigate the clinical efficacy of rectal mucosa columnar ligation injection combined with anal tightening operation in the treatment of rectal prolapse.Methods: Thirty patients with rectal prolapse were treated with rectal mucosa columnar ligation injection combined with anal tightening operation,the curative effects were observed.Results: Among 30 patients with rectal prolapse,29 cases cured,and 1 case improved,the cure rate of which was 96.67%(29/30).The differences of the levels of WBC,RBC,Hb and PLT in all csase before and after operation were not statistically significant(P>0.05).The neutrophils level at 1 day after operation was significantly higher than that in before operation and postoperative 5 days(P<0.01),the difference of neutrophils level between before operation and postoperative 5 days was not statistically significant(P>0.05).Conclusions: The clinical curative effects of rectal mucosa columnar ligation injection combined with anal tightening operation on treating rectal prolapse is good,which is worthy of clinical application.
2014, 39(8): 1034-1036.
Abstract:
Objective: To study the clinical value of brain natriuretic peptide(BNP) assay in the diagnosis of chronic obstructive pulmonary disease(COPD) complicating with acute dyspnea.Methods: Seventy-eight COPD patients presenting with acute dyspnea were divided into 3 groups:group A contained 43 patients without heart insufficiency,group B 15 patients complicating with left heart insufficiency and group C 20 patients complicating with right heart insufficiency.The plasma BNP levels and ultrasonic cardiogram were measured and compared among the 3 groups;and the BNP cut-off value was determined by the subject performance curve.Results: The BNP level was(60.3±55.8)pg/ml in group A,(1 489.4±1 011.3)pg/ml in group B and(437.9±391.3)pg/ml in group C;the difference was significant among the 3 groups(P<0.01).Echocardiography data showed that the left ventricular inner diameter in group A and group C was significantly less than that in group B;the left ventricular ejection fraction in group A was significantly higher than that in group B and group C(P<0.01),and the left ventricular ejection fraction in group C was significantly higher than that in group B(P<0.01);The internal dimension of the right ventricular and the pulmonary artery pressure in group C were higher than those in group B and group A(P<0.01);The internal dimension of the right ventricle/left ventricle in group B was significantly less than that in group A and group C(P<0.01).The BNP cut-off value was defined as 100 pg/ml by subjects performance curve;the sensitivity of cardiac insufficiency was predicted as 83.5%,and the specificity as 81.5%.Conclusions: The measurement of the plasma BNP level is essential to differential diagnosis of dyspnea etiology in patients with COPD;and the BNP levels are correlated with the type of the heart insufficiency.
Objective: To study the clinical value of brain natriuretic peptide(BNP) assay in the diagnosis of chronic obstructive pulmonary disease(COPD) complicating with acute dyspnea.Methods: Seventy-eight COPD patients presenting with acute dyspnea were divided into 3 groups:group A contained 43 patients without heart insufficiency,group B 15 patients complicating with left heart insufficiency and group C 20 patients complicating with right heart insufficiency.The plasma BNP levels and ultrasonic cardiogram were measured and compared among the 3 groups;and the BNP cut-off value was determined by the subject performance curve.Results: The BNP level was(60.3±55.8)pg/ml in group A,(1 489.4±1 011.3)pg/ml in group B and(437.9±391.3)pg/ml in group C;the difference was significant among the 3 groups(P<0.01).Echocardiography data showed that the left ventricular inner diameter in group A and group C was significantly less than that in group B;the left ventricular ejection fraction in group A was significantly higher than that in group B and group C(P<0.01),and the left ventricular ejection fraction in group C was significantly higher than that in group B(P<0.01);The internal dimension of the right ventricular and the pulmonary artery pressure in group C were higher than those in group B and group A(P<0.01);The internal dimension of the right ventricle/left ventricle in group B was significantly less than that in group A and group C(P<0.01).The BNP cut-off value was defined as 100 pg/ml by subjects performance curve;the sensitivity of cardiac insufficiency was predicted as 83.5%,and the specificity as 81.5%.Conclusions: The measurement of the plasma BNP level is essential to differential diagnosis of dyspnea etiology in patients with COPD;and the BNP levels are correlated with the type of the heart insufficiency.
2014, 39(8): 1037-1039.
Abstract:
Objective: To investigate the effects of endobutton in the treatment of acromioclavicular joint dislocation.Methods: Thirty-one patients with Rockwood Ⅲ,Ⅳ and Ⅴ type cromioclavicular joint dislocation were treated with the modified button plate internal fixation.The shoulder joint function was evaluated according to Constant-Murley score.Results: All patients were followed up for 5 to 26 months.The average Constant scores before operation,at 1 week,and 1,3 and 6 month after operation were(30.2±6.3),(86.3±6.3),(93.2±3.5),(95.2±3.1) and(95.4±3.7),respectively.The difference of Constant-Murley score between before and after operation was statistically significant(P<0.01).Conclusions: The effect of endobutton in the treatment of acromioclavicular joint dislocation is good,which is an ideal treatment for acromioclavicular joint dislocation.
Objective: To investigate the effects of endobutton in the treatment of acromioclavicular joint dislocation.Methods: Thirty-one patients with Rockwood Ⅲ,Ⅳ and Ⅴ type cromioclavicular joint dislocation were treated with the modified button plate internal fixation.The shoulder joint function was evaluated according to Constant-Murley score.Results: All patients were followed up for 5 to 26 months.The average Constant scores before operation,at 1 week,and 1,3 and 6 month after operation were(30.2±6.3),(86.3±6.3),(93.2±3.5),(95.2±3.1) and(95.4±3.7),respectively.The difference of Constant-Murley score between before and after operation was statistically significant(P<0.01).Conclusions: The effect of endobutton in the treatment of acromioclavicular joint dislocation is good,which is an ideal treatment for acromioclavicular joint dislocation.
2014, 39(8): 1039-1041.
Abstract:
Objective: To investigate the curative effects of endovenous laser in the treatment of varicose great saphenous veins.Methods: One hundred and seventy-nine limbs(138 patients) with varicose great saphenous veins were treated with high ligated,the venous trunk and lower leg varicose veins were treated with photocoagulation.Local resection or dot stripping were performed in severely varicose veins of shank.Results: The cure rate was 96.9%(172/179).Six cases with remnant varicose veins after operation were cured by resection under local anesthesia or laser photocoagulation again.The local funicular callosity in 124 great saphenous veins and shank,and skin ambustion in 5 cases were found.The duration of postoperative hospital stay was 4 to 7 days.One hundred and twenty-one cases were followed for 1 to 20 months,no case recurred.Conclusions: Endovenous laser for treating varicose great saphenous veins is micro-trauma and good effects.
Objective: To investigate the curative effects of endovenous laser in the treatment of varicose great saphenous veins.Methods: One hundred and seventy-nine limbs(138 patients) with varicose great saphenous veins were treated with high ligated,the venous trunk and lower leg varicose veins were treated with photocoagulation.Local resection or dot stripping were performed in severely varicose veins of shank.Results: The cure rate was 96.9%(172/179).Six cases with remnant varicose veins after operation were cured by resection under local anesthesia or laser photocoagulation again.The local funicular callosity in 124 great saphenous veins and shank,and skin ambustion in 5 cases were found.The duration of postoperative hospital stay was 4 to 7 days.One hundred and twenty-one cases were followed for 1 to 20 months,no case recurred.Conclusions: Endovenous laser for treating varicose great saphenous veins is micro-trauma and good effects.
2014, 39(8): 1042-1043.
Abstract:
Objective: To analyze the clinical effects of standard mega-bone flap craniotomy decompression in the treatment of severely craniocerebral injury.Methods: Seventy-eight patients with severely craniocerebral injury(Glasgow Coma Scale≤8 points) were treated with standard mega-bone flap craniotomy decompression.The Glasgow Outcome Scale and complications of all patients were observed in 6 months after treatment.Results: The delayed intracranial hematoma in 9 cases,cerebrospinal fluid leakage of incision in 2 cases,bilaterally subdural effusion in 5 cases,lung infection in 3 cases and epilepsy in 1 case were found after operation.All cases were followed up,good recovery in 16 cases,moderate disabilities in 17 cases,severe disabilities in 15 cases,vegetative state in 12 cases and death in 18 cases were verified.Five cases with secondary intracranial pressure were operated again.Conclusions: The standard mega-bone flap craniotomy decompression is an ideal surgical method in treating severely craniocerebral injury.The vital signs of patients after surgery should be closely observed,early detection and treatment of complications are important.
Objective: To analyze the clinical effects of standard mega-bone flap craniotomy decompression in the treatment of severely craniocerebral injury.Methods: Seventy-eight patients with severely craniocerebral injury(Glasgow Coma Scale≤8 points) were treated with standard mega-bone flap craniotomy decompression.The Glasgow Outcome Scale and complications of all patients were observed in 6 months after treatment.Results: The delayed intracranial hematoma in 9 cases,cerebrospinal fluid leakage of incision in 2 cases,bilaterally subdural effusion in 5 cases,lung infection in 3 cases and epilepsy in 1 case were found after operation.All cases were followed up,good recovery in 16 cases,moderate disabilities in 17 cases,severe disabilities in 15 cases,vegetative state in 12 cases and death in 18 cases were verified.Five cases with secondary intracranial pressure were operated again.Conclusions: The standard mega-bone flap craniotomy decompression is an ideal surgical method in treating severely craniocerebral injury.The vital signs of patients after surgery should be closely observed,early detection and treatment of complications are important.
2014, 39(8): 1044-1045,1048.
Abstract:
Objective: To explore the rational treatment of the contusion and laceration of double frontal lobes.Methods: The clinical data of 42 patients with contusion and laceration of double frontal lobes were analyzed retrospectively from January 2011 to October 2013.Twenty-eight cases and 24 cases were treated with operation and non-operation,respectively.Results: All patients were followed-up for 6 months to 1 year.Good in 35 cases,moderate disability in 4 cases,severe disability in 2 cases and death in 1 case were found by the Glasgow outcome scale.Conclusions: The patients with contusion and laceration of double frontal lobes should be greatly paid attention,the pupils of patients should be strictly observed,and the monitoring intracranial pressure and reexamining dynamic skull CT are implemented when it be needed.Correctly grasping the operation indication and active treatment are the key to the treatment.
Objective: To explore the rational treatment of the contusion and laceration of double frontal lobes.Methods: The clinical data of 42 patients with contusion and laceration of double frontal lobes were analyzed retrospectively from January 2011 to October 2013.Twenty-eight cases and 24 cases were treated with operation and non-operation,respectively.Results: All patients were followed-up for 6 months to 1 year.Good in 35 cases,moderate disability in 4 cases,severe disability in 2 cases and death in 1 case were found by the Glasgow outcome scale.Conclusions: The patients with contusion and laceration of double frontal lobes should be greatly paid attention,the pupils of patients should be strictly observed,and the monitoring intracranial pressure and reexamining dynamic skull CT are implemented when it be needed.Correctly grasping the operation indication and active treatment are the key to the treatment.
2014, 39(8): 1046-1048.
Abstract:
Objective: To evaluate the therapeutic effects of uterine artery embolization on hysteromyoma and its influence on ovarian function.Methods: The embolization agents were injected into the bilateral uterine arteries of 46 patients with hysteromyoma using the Seldinger technique via the percutaneous femoral arterial catheterization.All patients were followed up for 3 to 6 months.The clinical symptoms,volume of uterus and hysteromyoma and ovarian endocrine function in all cases were observed before and after interventional therapy.The volume of uterine and hysteromyoma and level of hormone(E2,FSH and LH) of ovary were measured before and after uterine artery embolization.Results: The uterine artery embolization in 46 patients were successful,the symptoms of all cases were significantly improved.The average volumes of uterus and hysteromyoma were(325.9±43.61) cm3 and(57.4±19.47) cm3 before treatment,respectively.The volumes of uterus and hysteromyoma shrunk 40.1% & 38.5% and 52.0% & 67.2% in 3 and 6 months after embolization,respectively,the differences of which were statistically significant(P<0.01).The differences of the levels of E2,FSH and LH between before and after treatment were not statistically significant(P>0.05).Conclusions: Uterine artery embolization can significantly improve the clinical symptoms and shrink the volumes of uterus and hysteromyoma,which does not affect the physiological function of ovary.
Objective: To evaluate the therapeutic effects of uterine artery embolization on hysteromyoma and its influence on ovarian function.Methods: The embolization agents were injected into the bilateral uterine arteries of 46 patients with hysteromyoma using the Seldinger technique via the percutaneous femoral arterial catheterization.All patients were followed up for 3 to 6 months.The clinical symptoms,volume of uterus and hysteromyoma and ovarian endocrine function in all cases were observed before and after interventional therapy.The volume of uterine and hysteromyoma and level of hormone(E2,FSH and LH) of ovary were measured before and after uterine artery embolization.Results: The uterine artery embolization in 46 patients were successful,the symptoms of all cases were significantly improved.The average volumes of uterus and hysteromyoma were(325.9±43.61) cm3 and(57.4±19.47) cm3 before treatment,respectively.The volumes of uterus and hysteromyoma shrunk 40.1% & 38.5% and 52.0% & 67.2% in 3 and 6 months after embolization,respectively,the differences of which were statistically significant(P<0.01).The differences of the levels of E2,FSH and LH between before and after treatment were not statistically significant(P>0.05).Conclusions: Uterine artery embolization can significantly improve the clinical symptoms and shrink the volumes of uterus and hysteromyoma,which does not affect the physiological function of ovary.
2014, 39(8): 1049-1050,1053.
Abstract:
Objective: To investigate the clinical effects of autologous single-bundle hamstring tendon in the reconstruction of anterior cruciate ligament(ACL) under arthroscopy.Methods: Fifteen patients with ACL rupture diagnosed by arthroscopy were treated with the single bundle reconstruction of autologous quadrupled hamstring tendons.The femur and tibia ends were fixed by the Endobutton system and interference screw,respectively.Results: All patients were followed up for 3 to 12 months,no severe complication occurred,the knee joint stability was strengthened.The Lachman test was negative in 12 cases,and the Lachman test was weakly positive in 3cases.The range of knee joint activity was 120° to 160° at the last follow-up.The Lysholm scores of the knee joint function before and after operation were 56 to 76 and 86 to 100,respectively.The knee joint activities of all patients recovered.Conclusions: The reconstruction ACL with autologous single-bundle hamstring tendon under arthroscopy is a reliable method for recovering the stability of knee joint.
Objective: To investigate the clinical effects of autologous single-bundle hamstring tendon in the reconstruction of anterior cruciate ligament(ACL) under arthroscopy.Methods: Fifteen patients with ACL rupture diagnosed by arthroscopy were treated with the single bundle reconstruction of autologous quadrupled hamstring tendons.The femur and tibia ends were fixed by the Endobutton system and interference screw,respectively.Results: All patients were followed up for 3 to 12 months,no severe complication occurred,the knee joint stability was strengthened.The Lachman test was negative in 12 cases,and the Lachman test was weakly positive in 3cases.The range of knee joint activity was 120° to 160° at the last follow-up.The Lysholm scores of the knee joint function before and after operation were 56 to 76 and 86 to 100,respectively.The knee joint activities of all patients recovered.Conclusions: The reconstruction ACL with autologous single-bundle hamstring tendon under arthroscopy is a reliable method for recovering the stability of knee joint.
2014, 39(8): 1051-1053.
Abstract:
Objective: To explore the effects of the combined disconnection operation on preventing upper gastrointestinal hemorrhage of patients with portal hypertension.Methods: The muscle layer and mucosa blood vessels of lower esophagus were cut off using tubular anastomat through abdomen in 5 cases after splenectomy and cutting off peripheral vascular of cardia,which could prevent the upper gastrointestinal hemorrhage of patients with portal hypertension.The operation preparation,operation time,operation means and complication treatment of joint cut-out operation were analyzed.Results: Cure in 50 cases,death in 1 case,anastomotic fistula in 1 case and anastomotic stenosis in 1 case were found.Different degree ascites in 23 cases and fever in 9 cases were found after operation.All cases were followed up for 7 years,no hemorrhage occurred.Conclusions: The combined disconnection operation is an effective method to treat the upper gastrointestinal hemorrhage of patients with portal hypertension
Objective: To explore the effects of the combined disconnection operation on preventing upper gastrointestinal hemorrhage of patients with portal hypertension.Methods: The muscle layer and mucosa blood vessels of lower esophagus were cut off using tubular anastomat through abdomen in 5 cases after splenectomy and cutting off peripheral vascular of cardia,which could prevent the upper gastrointestinal hemorrhage of patients with portal hypertension.The operation preparation,operation time,operation means and complication treatment of joint cut-out operation were analyzed.Results: Cure in 50 cases,death in 1 case,anastomotic fistula in 1 case and anastomotic stenosis in 1 case were found.Different degree ascites in 23 cases and fever in 9 cases were found after operation.All cases were followed up for 7 years,no hemorrhage occurred.Conclusions: The combined disconnection operation is an effective method to treat the upper gastrointestinal hemorrhage of patients with portal hypertension
2014, 39(8): 1054-1055,1058.
Abstract:
Objective: To investigate the clinical effects of stereotactic soft channel technology in the treatment of cerebral hemorrhage.Methods: Forty patients with hypertensive cerebral hemorrhage were randomly divided into the minimally invasive group and control group(20 cases each group).The minimally invasive group and control group were treated with the stereotactic minimally invasive treatment of soft-channel technology and conventional therapy,respectively.Results: The dead patients in minimally invasive group(4 cases) were less than that in control group(10 cases)(P<0.05).The differences of Scandinavian Stroke Scale and Activity of Dolily Living Scale neurological outcome assessment between two groups were statistically significant(P<0.01).Conclusions: The clinical effects of stereotactic soft channel technology in the treatment of hypertensive cerebral hemorrhage are good,which is minimally invasive,safe,reliable and low mortality and morbidity,and is worth promoting.
Objective: To investigate the clinical effects of stereotactic soft channel technology in the treatment of cerebral hemorrhage.Methods: Forty patients with hypertensive cerebral hemorrhage were randomly divided into the minimally invasive group and control group(20 cases each group).The minimally invasive group and control group were treated with the stereotactic minimally invasive treatment of soft-channel technology and conventional therapy,respectively.Results: The dead patients in minimally invasive group(4 cases) were less than that in control group(10 cases)(P<0.05).The differences of Scandinavian Stroke Scale and Activity of Dolily Living Scale neurological outcome assessment between two groups were statistically significant(P<0.01).Conclusions: The clinical effects of stereotactic soft channel technology in the treatment of hypertensive cerebral hemorrhage are good,which is minimally invasive,safe,reliable and low mortality and morbidity,and is worth promoting.
2014, 39(8): 1056-1058.
Abstract:
Objective: To explore the relationship between Helicobacter pylori(Hp) infection and immune thrombocytopenia(ITP) in children.Methods: One hundred and four children with ITP and 30 healthy children were performed Hp antibodies examination using immunochromatographic assay,and all the ITP patients with Hp infection received triple therapy for two weeks.Results: Fifty-four of the 104 cases with ITP proved to have positive Hp(51.92%),while there were only 8 cases in the healthy group presenting positive Hp(26.67%);the positive rate of Hp antibodies was higher in the ITP group than in the normal control(P<0.05).After triple therapy,complete response was observed in 36 of the 54 cases with Hp infection,partial response in 15 cases and no response in 3 cases;the total effective rate was 94.44%.Conclusions: Hp infection is associated with the TIP in children.
Objective: To explore the relationship between Helicobacter pylori(Hp) infection and immune thrombocytopenia(ITP) in children.Methods: One hundred and four children with ITP and 30 healthy children were performed Hp antibodies examination using immunochromatographic assay,and all the ITP patients with Hp infection received triple therapy for two weeks.Results: Fifty-four of the 104 cases with ITP proved to have positive Hp(51.92%),while there were only 8 cases in the healthy group presenting positive Hp(26.67%);the positive rate of Hp antibodies was higher in the ITP group than in the normal control(P<0.05).After triple therapy,complete response was observed in 36 of the 54 cases with Hp infection,partial response in 15 cases and no response in 3 cases;the total effective rate was 94.44%.Conclusions: Hp infection is associated with the TIP in children.
2014, 39(8): 1059-1061.
Abstract:
Objective: To investigate the clinical effect of low ovarian chocolate cysts after mifepristone with GnRHa therapy. Methods: Ninety-seven cases that they were underwent laparoscopic cystectomy chocolate unilateral ovarian chocolate cysts were choosed, by the use of digital they were randomly divided into observation group 49 cases and control group 48 cases.Second day after operation observation group started low doses of oral mifepristone,10 mg/d, continued to take 3 months; and after the first menstrual cramps second day intramuscular GnRHa,3.75 mg every time,every 28 days,continuous injection of three times.Control group was injected GnRHa, treatment methods with the observation group.After 1 year,the treatment of two groups were compared,and the recording of adverse reactions observed appears.Results: After 1 year, the total effective rate and the recurrence rate of the observation group were 100.00% and 4.08% respectively;the total effective rate and the recurrence rate of the control group were 87.50% and 14.58%,respectively.The total efficiency and recurrence rate between the two groups were not significantly different(P>0.05).Before and after treatment between the two groups in serum FSH,LH,E2,P was not statistically significant (P>0.05);former levels of serum FSH,LH,E2,P level of treatment and treatment after comparison,FSH was significantly improved water,LH,E2,P levels were significantly reduced,and the differences were statistically significant(P<0.01).The incidence of adverse reaction in the observation group and the control group were 38.78% and 35.42%,was not statistically significant(P>0.05).Conclusions: Effect of low dose mifepristone combined with GnRHa treatment in chocolate cyst of ovary well after operation,the recurrence rate is low,and will help to improve ovarian function.
Objective: To investigate the clinical effect of low ovarian chocolate cysts after mifepristone with GnRHa therapy. Methods: Ninety-seven cases that they were underwent laparoscopic cystectomy chocolate unilateral ovarian chocolate cysts were choosed, by the use of digital they were randomly divided into observation group 49 cases and control group 48 cases.Second day after operation observation group started low doses of oral mifepristone,10 mg/d, continued to take 3 months; and after the first menstrual cramps second day intramuscular GnRHa,3.75 mg every time,every 28 days,continuous injection of three times.Control group was injected GnRHa, treatment methods with the observation group.After 1 year,the treatment of two groups were compared,and the recording of adverse reactions observed appears.Results: After 1 year, the total effective rate and the recurrence rate of the observation group were 100.00% and 4.08% respectively;the total effective rate and the recurrence rate of the control group were 87.50% and 14.58%,respectively.The total efficiency and recurrence rate between the two groups were not significantly different(P>0.05).Before and after treatment between the two groups in serum FSH,LH,E2,P was not statistically significant (P>0.05);former levels of serum FSH,LH,E2,P level of treatment and treatment after comparison,FSH was significantly improved water,LH,E2,P levels were significantly reduced,and the differences were statistically significant(P<0.01).The incidence of adverse reaction in the observation group and the control group were 38.78% and 35.42%,was not statistically significant(P>0.05).Conclusions: Effect of low dose mifepristone combined with GnRHa treatment in chocolate cyst of ovary well after operation,the recurrence rate is low,and will help to improve ovarian function.
2014, 39(8): 1062-1064.
Abstract:
Objective: To explore the clinical effects of vacuum sealing drainage(VSD) technology combined with medial supramalleolar perforator flap of posterior tibial artery in repairing foot and ankle wound infection.Methods: Sixteen patients with foot and ankle wound infection were treated with VSD technology at first.The medial supramalleolar perforator flap of posterior tibial artery with 4 cm×10 cm to 8 cm×14 cm was designed,and then the flap was transplanted into the defect site of foot and ankle to repair soft tissue.Results: All flaps survived,and the flap was soft texture and good appearance.No obvious complication was found in donor site.The score of patient satisfaction was 6 to 9 points.Conclusions: VSD technology can promote the recovery of wound infection,and shorten the duration of disease.The clinical effects of VSD technology combined with medial supramalleolar perforator flap of posterior tibial artery in repairing foot and ankle wound infection are good.
Objective: To explore the clinical effects of vacuum sealing drainage(VSD) technology combined with medial supramalleolar perforator flap of posterior tibial artery in repairing foot and ankle wound infection.Methods: Sixteen patients with foot and ankle wound infection were treated with VSD technology at first.The medial supramalleolar perforator flap of posterior tibial artery with 4 cm×10 cm to 8 cm×14 cm was designed,and then the flap was transplanted into the defect site of foot and ankle to repair soft tissue.Results: All flaps survived,and the flap was soft texture and good appearance.No obvious complication was found in donor site.The score of patient satisfaction was 6 to 9 points.Conclusions: VSD technology can promote the recovery of wound infection,and shorten the duration of disease.The clinical effects of VSD technology combined with medial supramalleolar perforator flap of posterior tibial artery in repairing foot and ankle wound infection are good.
2014, 39(8): 1065-1067.
Abstract:
Objective: To observe the clinical efficacy of small craniotomy in the treatment of hypertensive cerebellar hemorrhage.Methods: Twelve patients with hypertensive cerebellar hemorrhage were treated with small craniotomy.The operation time,removing hematoma and treatment effects of all cases were observed.Results: The operation time was 1.5 hour.The hematomas were completely and partly removed in 8 cases and 4 cases.All patients were followed up for 3 months,11 cases survived.Good recovery in 7 cases,slight disability in 3 cases and severe disability in 1 case were found according to the Glasgow prognosis score.Conclusions: The small craniotomy is short operation time,small trauma,little bleeding,and good efficacy,which is a suitable treatment means for hypertensive cerebellar hemorrhage.
Objective: To observe the clinical efficacy of small craniotomy in the treatment of hypertensive cerebellar hemorrhage.Methods: Twelve patients with hypertensive cerebellar hemorrhage were treated with small craniotomy.The operation time,removing hematoma and treatment effects of all cases were observed.Results: The operation time was 1.5 hour.The hematomas were completely and partly removed in 8 cases and 4 cases.All patients were followed up for 3 months,11 cases survived.Good recovery in 7 cases,slight disability in 3 cases and severe disability in 1 case were found according to the Glasgow prognosis score.Conclusions: The small craniotomy is short operation time,small trauma,little bleeding,and good efficacy,which is a suitable treatment means for hypertensive cerebellar hemorrhage.
2014, 39(8): 1067-1069.
Abstract:
Objective: To investigate the clinical efficacy of azithromycin in the treatment of mycoplasmal pneumonia.Methods: Fifty children with mycoplasmal pneumonia were randomly divided into two groups.The 25 cases in the control group received the therapy of erythromycin 30 mg/kg,1 time/day,continuously for 5 days and a 2-day withdrawal as one course,and the 25 cases in the observation group azithromycin 10 mg/kg,1 time/day,continuously for 5 days and a 2-day withdrawal as one course.The clinical efficacy and changes of pulmonary ventilation function were compared between the two groups.Results: The total response rate of the observation group was 96.0%,which was higher than that of the control(76.0%)(P<0.05).The time of cough disappearing,rales disappearing and hospital stay of the observation group was shorter than that of the control group(P<0.01);the Forced vital capacity and Forced expiratory volume in 1 second of the observation group were higher than those of the control group after 2 months' treatment(P<0.01);the gastrointestinal reaction of the observation group was less than that of the control group(P<0.05).Conclusions: The clinical efficacy of azithromycin is confirmed for treatment of mycoplasmal pneumonia.It may shorten the duration of the clinical symptoms and signs,decrease the treatment time and hospital stay,reduce the adverse reaction and improve the lung function.
Objective: To investigate the clinical efficacy of azithromycin in the treatment of mycoplasmal pneumonia.Methods: Fifty children with mycoplasmal pneumonia were randomly divided into two groups.The 25 cases in the control group received the therapy of erythromycin 30 mg/kg,1 time/day,continuously for 5 days and a 2-day withdrawal as one course,and the 25 cases in the observation group azithromycin 10 mg/kg,1 time/day,continuously for 5 days and a 2-day withdrawal as one course.The clinical efficacy and changes of pulmonary ventilation function were compared between the two groups.Results: The total response rate of the observation group was 96.0%,which was higher than that of the control(76.0%)(P<0.05).The time of cough disappearing,rales disappearing and hospital stay of the observation group was shorter than that of the control group(P<0.01);the Forced vital capacity and Forced expiratory volume in 1 second of the observation group were higher than those of the control group after 2 months' treatment(P<0.01);the gastrointestinal reaction of the observation group was less than that of the control group(P<0.05).Conclusions: The clinical efficacy of azithromycin is confirmed for treatment of mycoplasmal pneumonia.It may shorten the duration of the clinical symptoms and signs,decrease the treatment time and hospital stay,reduce the adverse reaction and improve the lung function.
2014, 39(8): 1070-1072.
Abstract:
Objective: To analyze the clinical effect of epidural painless parturition technology.Methods: Ninety cases of single cephalic term pregnant women were selected,the observation group of 45 cases with painless delivery and control group of 45 cases with conventional delivery.The analgesic effect,labor time,the rate of cesarean section,postpartum hemorrhage,fetal distress and neonatal asphyxia of the two groups were observed.Results: The effect of observation group was better than that of the control group(P<0.01),the first stage of labor and the total labor time were shorter significantly than the control group(P<0.01).The rate of cesarean section postpartum hemorrhage,fetal distress and neonatal asphyxia had no difference significantly(P>0.05).Conclusions: The analgesic effect of epidural painless parturition is obviously,the labor is shortened,and it has no adverse effect on maternal and neonates.
Objective: To analyze the clinical effect of epidural painless parturition technology.Methods: Ninety cases of single cephalic term pregnant women were selected,the observation group of 45 cases with painless delivery and control group of 45 cases with conventional delivery.The analgesic effect,labor time,the rate of cesarean section,postpartum hemorrhage,fetal distress and neonatal asphyxia of the two groups were observed.Results: The effect of observation group was better than that of the control group(P<0.01),the first stage of labor and the total labor time were shorter significantly than the control group(P<0.01).The rate of cesarean section postpartum hemorrhage,fetal distress and neonatal asphyxia had no difference significantly(P>0.05).Conclusions: The analgesic effect of epidural painless parturition is obviously,the labor is shortened,and it has no adverse effect on maternal and neonates.
2014, 39(8): 1072-1073.
Abstract:
Objective: To explore the effects of the low-dose aminophylline injection through micro-pump in the treatment of asthmatic bronchitis of children.Methods: One hundred and twenty-two children with asthmatic bronchitis were randomly divided into the treatment group(62 case) and control group(60 cases).The control group were treated with traditional method,the treatment group were treated with low-dose aminophylline on the basis of traditional method.The therapeutic effects between two groups were compared.Results: The total effective rate in treatment group was higher than that in control group after treatment(P<0.01).The cough,rales wheezing sound in treatment group were significantly better than those in control group after treatment(P<0.01).Conclusions: The effects of low-dose aminophylline in the treatment of asthmatic bronchitis in children are remarkable.It can effectively improve the clinical symptoms,which is worthy of clinical popularization and application.
Objective: To explore the effects of the low-dose aminophylline injection through micro-pump in the treatment of asthmatic bronchitis of children.Methods: One hundred and twenty-two children with asthmatic bronchitis were randomly divided into the treatment group(62 case) and control group(60 cases).The control group were treated with traditional method,the treatment group were treated with low-dose aminophylline on the basis of traditional method.The therapeutic effects between two groups were compared.Results: The total effective rate in treatment group was higher than that in control group after treatment(P<0.01).The cough,rales wheezing sound in treatment group were significantly better than those in control group after treatment(P<0.01).Conclusions: The effects of low-dose aminophylline in the treatment of asthmatic bronchitis in children are remarkable.It can effectively improve the clinical symptoms,which is worthy of clinical popularization and application.
2014, 39(8): 1074-1076.
Abstract:
Objective: To compare the efficacy and safety between laparoscopic assisted radical resection and laparotomy for colorectal cancer for evaluating the feasibility,safety and oncological clearance of laparoscopic assisted radical resection.Methods: The clinical data(including operation index,postoperative recovery index,radical index and postoperative complication) of 66 patients treated with laparoscopic assisted radical resection and 95 patients treated with laparotomy were compared.Results: The operation time and intraoperative blood loss in laparoscopy and laparotomy group were(185.2±30.12) min &(121.3±20.45) min,and(123.6±57.8) ml &(197.8±87.6) ml,respectively,the differences of which were statistical significance(P<0.01).The postoperative anal exhaust time in laparoscopy and laparotomy group were(2.87±0.25) day and(3.52±0.19) day,the difference of which was statistical significance(P<0.01).The difference of the incidence of postoperative complication between two groups was not statistical significance(P>0.05).The postoperative hospitalization time of laparoscopy(10.70±0.53) days was significantly shorter than that of laparotomy group(13.97±0.28) days(P<0.01).The number of resecting lymph node in laparoscopy group were significantly less than that in laparotomy group(P<0.01).The differences of the positive rate of incisal edge and 3-year survival rate between two groups were not statistical significance(P>0.05).Conclusions: The laparoscopic assisted radical resection for colorectal cancer is minimally invasive,less blood loss,less pain,quick recovery of gastrointestinal function and early out-of-bed,which can decrease the postoperative complications and stay.
Objective: To compare the efficacy and safety between laparoscopic assisted radical resection and laparotomy for colorectal cancer for evaluating the feasibility,safety and oncological clearance of laparoscopic assisted radical resection.Methods: The clinical data(including operation index,postoperative recovery index,radical index and postoperative complication) of 66 patients treated with laparoscopic assisted radical resection and 95 patients treated with laparotomy were compared.Results: The operation time and intraoperative blood loss in laparoscopy and laparotomy group were(185.2±30.12) min &(121.3±20.45) min,and(123.6±57.8) ml &(197.8±87.6) ml,respectively,the differences of which were statistical significance(P<0.01).The postoperative anal exhaust time in laparoscopy and laparotomy group were(2.87±0.25) day and(3.52±0.19) day,the difference of which was statistical significance(P<0.01).The difference of the incidence of postoperative complication between two groups was not statistical significance(P>0.05).The postoperative hospitalization time of laparoscopy(10.70±0.53) days was significantly shorter than that of laparotomy group(13.97±0.28) days(P<0.01).The number of resecting lymph node in laparoscopy group were significantly less than that in laparotomy group(P<0.01).The differences of the positive rate of incisal edge and 3-year survival rate between two groups were not statistical significance(P>0.05).Conclusions: The laparoscopic assisted radical resection for colorectal cancer is minimally invasive,less blood loss,less pain,quick recovery of gastrointestinal function and early out-of-bed,which can decrease the postoperative complications and stay.
2014, 39(8): 1095-1096,1099.
Abstract:
Objective: To investigate the relationship between the bacteria on the surface of mobile phone and hand hygiene in medical staff in emergency department.Methods: The bacteria culture and sensitivity test of the surface of mobile phone of 12 medical staff in emergency department were investigated for 3 days,the results of which were compared with those of the patients' specimens.Results: The 9 bacterial strains,such as Staphylococcus aureus,Staphylococcus epidermidis,Escherichia coli,Klebsiella pneumonia,Bauman Acinetobacter and so on(including 2 extensively drug-resistant bacteria strains of Staphylococcus aureus and Bauman Acinetobacter),on the surface of mobile phone of medical staff were detected by bacteria culture.The 12 bacterial strains,such as Staphylococcus aureus,Staphylococcus epidermidis,Escherichia coli,Klebsiella pneumonia,Bauman Acinetobacter and so on(including 3 extensively drug-resistant bacteria strains of Staphylococcus aureus,Bauman Acinetobacter and Escherichia coli),in patients' specimens were detected by bacteria culture.Conclusions: The mobile phone of medical stuff may be the media of bacterial cross infection.
Objective: To investigate the relationship between the bacteria on the surface of mobile phone and hand hygiene in medical staff in emergency department.Methods: The bacteria culture and sensitivity test of the surface of mobile phone of 12 medical staff in emergency department were investigated for 3 days,the results of which were compared with those of the patients' specimens.Results: The 9 bacterial strains,such as Staphylococcus aureus,Staphylococcus epidermidis,Escherichia coli,Klebsiella pneumonia,Bauman Acinetobacter and so on(including 2 extensively drug-resistant bacteria strains of Staphylococcus aureus and Bauman Acinetobacter),on the surface of mobile phone of medical staff were detected by bacteria culture.The 12 bacterial strains,such as Staphylococcus aureus,Staphylococcus epidermidis,Escherichia coli,Klebsiella pneumonia,Bauman Acinetobacter and so on(including 3 extensively drug-resistant bacteria strains of Staphylococcus aureus,Bauman Acinetobacter and Escherichia coli),in patients' specimens were detected by bacteria culture.Conclusions: The mobile phone of medical stuff may be the media of bacterial cross infection.
2014, 39(8): 1097-1099.
Abstract:
Objective: To investigate the composition and clustering status of controllable risk factors for cardiovascular disease in some cadres in Beijing.Methods: Seventy hundred and sixty-five cadres in Beijing were selected,and the composition and clustering status of controllable risk factors for cardiovascular disease were compared according to different age groups.Results: The composition and clustering rate of controllable risk factors for cardiovascular disease were risen with the growth of age(P<0.05 to P<0.01).The morbidity rate of hypertension was higher in 40-49 age,50-59 age and 60-age groups than that in 22-29 age and 30-39 age groups(P<0.05);the morbidity rate of diabetes was risen notably in 40-49 age and 50-59 age groups than that in 22-29 age and 30-39 age groups(P<0.05);the morbidity rate of high triglyceride and low high-density lipoprotein cholesterol was higher in 40-49 age group than that in 22-29 age groups(P<0.05),the morbidity rate of overweight/obesity rate and high triglyceride in 60～age group was lower than that in 30-39 age,40-49 age and 50-59 age groups(P<0.05),The clustering rates of 3 risk factors and 4 risk factors rise notably in 30-49 age group and 40-49 age group respectively(P<0.05).Conclusions: It should be focused on about the overweight/obesity and smoking among youth,and hypertension,diabetes among middle-aged and old cadres.The younger tendency of overweight/obesity influenced the cardiovascular health obviously.It is needed to correct life-style and strengthen dietary therapy targeting these diseases.
Objective: To investigate the composition and clustering status of controllable risk factors for cardiovascular disease in some cadres in Beijing.Methods: Seventy hundred and sixty-five cadres in Beijing were selected,and the composition and clustering status of controllable risk factors for cardiovascular disease were compared according to different age groups.Results: The composition and clustering rate of controllable risk factors for cardiovascular disease were risen with the growth of age(P<0.05 to P<0.01).The morbidity rate of hypertension was higher in 40-49 age,50-59 age and 60-age groups than that in 22-29 age and 30-39 age groups(P<0.05);the morbidity rate of diabetes was risen notably in 40-49 age and 50-59 age groups than that in 22-29 age and 30-39 age groups(P<0.05);the morbidity rate of high triglyceride and low high-density lipoprotein cholesterol was higher in 40-49 age group than that in 22-29 age groups(P<0.05),the morbidity rate of overweight/obesity rate and high triglyceride in 60～age group was lower than that in 30-39 age,40-49 age and 50-59 age groups(P<0.05),The clustering rates of 3 risk factors and 4 risk factors rise notably in 30-49 age group and 40-49 age group respectively(P<0.05).Conclusions: It should be focused on about the overweight/obesity and smoking among youth,and hypertension,diabetes among middle-aged and old cadres.The younger tendency of overweight/obesity influenced the cardiovascular health obviously.It is needed to correct life-style and strengthen dietary therapy targeting these diseases.
2014, 39(8): 1100-1103.
Abstract:
Objective: To investigate the clinical value of chest fluoroscopy,chest radiography and high-resolution computed tomography(CT) in the diagnosis of atypical foreign body in trachea and bronchus.Methods: The data of chest fluoroscopy,chest radiography and high-resolution CT in 45 cases with atypical foreign body in trachea and bronchus diagnosed by fiberbronchoscopy were analyzed and compared.Results: The positive rate,false positive rate,false negative rate and misdiagnosis rate of chest fluoroscopy were 52.94%,17.65%,11.76% and 17.65%,respectively.The positive rate,false positive rate,false negative rate and misdiagnosis rate of chest radiography were 53.85%,15.38%,15.38% and 15.38%,respectively.The positive rate of CT was 100.00%,its false positive and negative rates were 0.00% and 0.00%,respectively.The difference of the positive rate in diagnosing the atypical foreign body in trachea and bronchus between chest fluoroscopy and chest radiography was not statistically significant(P>0.05),but the diagnosic positive rate of high-resolation CT and reconstruction were higer than the fluoroscopy and radiography(P<0.05).Conclusions: The sensibilities of chest fluoroscopy and radiography in diagnosing the atypical foreign body in trachea and bronchus are low,but CT detection is high.The CT detection is a reliable and noninvasive method for demonstrating the typical foreign body in trachea and bronchus.
Objective: To investigate the clinical value of chest fluoroscopy,chest radiography and high-resolution computed tomography(CT) in the diagnosis of atypical foreign body in trachea and bronchus.Methods: The data of chest fluoroscopy,chest radiography and high-resolution CT in 45 cases with atypical foreign body in trachea and bronchus diagnosed by fiberbronchoscopy were analyzed and compared.Results: The positive rate,false positive rate,false negative rate and misdiagnosis rate of chest fluoroscopy were 52.94%,17.65%,11.76% and 17.65%,respectively.The positive rate,false positive rate,false negative rate and misdiagnosis rate of chest radiography were 53.85%,15.38%,15.38% and 15.38%,respectively.The positive rate of CT was 100.00%,its false positive and negative rates were 0.00% and 0.00%,respectively.The difference of the positive rate in diagnosing the atypical foreign body in trachea and bronchus between chest fluoroscopy and chest radiography was not statistically significant(P>0.05),but the diagnosic positive rate of high-resolation CT and reconstruction were higer than the fluoroscopy and radiography(P<0.05).Conclusions: The sensibilities of chest fluoroscopy and radiography in diagnosing the atypical foreign body in trachea and bronchus are low,but CT detection is high.The CT detection is a reliable and noninvasive method for demonstrating the typical foreign body in trachea and bronchus.
2014, 39(8): 1104-1106.
Abstract:
Objective: To evaluate the detection of serum cystatin C(Cys C) and the related indicators in diagnosis of early renal damage in diabetic mellitus patients.Methods: Fifty cases of type 2 diabetes patients and 30 normal subjects were studied;the latex-enhanced turbidimetric immunoassay,enzyme and immune nephelometry were employed to test the levels of serum Cys C,urea,creatinine,glomerular filtration rate and Urinary albumin(U-Alb) using Beckman AU5400 and Beckman IMMAGE800;then the results were compared between the two groups.Results: The levels of serum Cys C,U-Alb and urea in patients with diabetes mellitus were significantly higher than those in control group(P<0.01);however,the difference in the level of serum creatinine was not statistically significant(P>0.05).The area under the receiver operating characteristic curve analysis was 0.95 by Cys C curve,and the sensitivity and specificity were 92.1% and 72.0%,respectively;the area under receiver operating characteristic curve of U-Alb was 0.97,and sensitivity and specificity were 90.5% and 68.2%,respectively.Conclusions: Combination detection of the levels of serum Cys C and U-Alb may provide reliable basis for early diagnosis and intervention of the patients with early diabetic nephropathy.
Objective: To evaluate the detection of serum cystatin C(Cys C) and the related indicators in diagnosis of early renal damage in diabetic mellitus patients.Methods: Fifty cases of type 2 diabetes patients and 30 normal subjects were studied;the latex-enhanced turbidimetric immunoassay,enzyme and immune nephelometry were employed to test the levels of serum Cys C,urea,creatinine,glomerular filtration rate and Urinary albumin(U-Alb) using Beckman AU5400 and Beckman IMMAGE800;then the results were compared between the two groups.Results: The levels of serum Cys C,U-Alb and urea in patients with diabetes mellitus were significantly higher than those in control group(P<0.01);however,the difference in the level of serum creatinine was not statistically significant(P>0.05).The area under the receiver operating characteristic curve analysis was 0.95 by Cys C curve,and the sensitivity and specificity were 92.1% and 72.0%,respectively;the area under receiver operating characteristic curve of U-Alb was 0.97,and sensitivity and specificity were 90.5% and 68.2%,respectively.Conclusions: Combination detection of the levels of serum Cys C and U-Alb may provide reliable basis for early diagnosis and intervention of the patients with early diabetic nephropathy.
2014, 39(8): 1107-1110.
Abstract:
Objective: To knowledge the characteristics of pathogen microbes in 0 to 5 years old children with acute diarrhea,and provide the basis for effective treatment.Methods: The 310 stool specimens from less than 5 years old children with diarrhea were collected for routine bacteria culture to screen the pathogenic bacteria from April 2012 to March 2013.The virus was detected using ELISA,and virus genotype was determined by PCR.Results: The virus in 121 cases(39.03%) were postive,the rotavirus was the main pathogenic virus.The bacteria in 24 cases(7.74%) were positive,the Salmonella was imjor.Virus and bacterial co-infection was not found.The difference of infection rate between gender was not statistical significance(P>0.05).Rotavirus infection occured mainly in Autumn and Winter,the popular type was G2,G3,and P[8],18 to 23 weeks old children were a high-risk group.The bacterial and goblet viral diarrhea was prevalent in summer.Conclusions: Rotavirus infection is the main pathogen of infectious diarrhea,bacterial infection also accounted for certain proportion in Yongchuan district.Strengthening the pathogen monitoring can provide the basis for clinical treatment.
Objective: To knowledge the characteristics of pathogen microbes in 0 to 5 years old children with acute diarrhea,and provide the basis for effective treatment.Methods: The 310 stool specimens from less than 5 years old children with diarrhea were collected for routine bacteria culture to screen the pathogenic bacteria from April 2012 to March 2013.The virus was detected using ELISA,and virus genotype was determined by PCR.Results: The virus in 121 cases(39.03%) were postive,the rotavirus was the main pathogenic virus.The bacteria in 24 cases(7.74%) were positive,the Salmonella was imjor.Virus and bacterial co-infection was not found.The difference of infection rate between gender was not statistical significance(P>0.05).Rotavirus infection occured mainly in Autumn and Winter,the popular type was G2,G3,and P[8],18 to 23 weeks old children were a high-risk group.The bacterial and goblet viral diarrhea was prevalent in summer.Conclusions: Rotavirus infection is the main pathogen of infectious diarrhea,bacterial infection also accounted for certain proportion in Yongchuan district.Strengthening the pathogen monitoring can provide the basis for clinical treatment.
2014, 39(8): 1110-1112.
Abstract:
Objective: To explore the correlation of the ACR of morning and random urine and 24 hour urinary albumin(24 h UA),and the application of random urinary ACR replacing 24 h UA in screening the early renal injury of type 2 diabetic patients.Methods: The morning and random urine of 89 type 2 diabetic patients were collected,the diagnostic sensitivity and specificity and correlation of the ACR of morning and random urine and 24 h UA was compared.The curves of ACR and ROC of morning and random urine were established using the standard of 24 h UA,the area under the ROC curve was compared.Results: The ACR of morning and random urine were 9.02 and 8.65 mg/mmol,the difference of which was not statistically significant(P>0.05).The ACR in morning urine and random urine was positive correlation(r=0.951,P<0.01),the ACR of morning urine and random urine were greatly positive correlation with 24 h UA(P<0.01).The sensitivity and specificity of the ACR of morning and random urine in screening albuminuria were 92.6%& 90.1%and 87.5%& 87.5%,respectively.The areas under ROC curve of the ACR of morning urine and random urine were 0.942±0.020 and 0.949±0.019,respectively(P>0.05).Conclusions: The random urine ACR is good correlation with 24 h UA,which can replace 24 h UA in screening and monitoring the early renal injury of type 2 diabetic patients.
Objective: To explore the correlation of the ACR of morning and random urine and 24 hour urinary albumin(24 h UA),and the application of random urinary ACR replacing 24 h UA in screening the early renal injury of type 2 diabetic patients.Methods: The morning and random urine of 89 type 2 diabetic patients were collected,the diagnostic sensitivity and specificity and correlation of the ACR of morning and random urine and 24 h UA was compared.The curves of ACR and ROC of morning and random urine were established using the standard of 24 h UA,the area under the ROC curve was compared.Results: The ACR of morning and random urine were 9.02 and 8.65 mg/mmol,the difference of which was not statistically significant(P>0.05).The ACR in morning urine and random urine was positive correlation(r=0.951,P<0.01),the ACR of morning urine and random urine were greatly positive correlation with 24 h UA(P<0.01).The sensitivity and specificity of the ACR of morning and random urine in screening albuminuria were 92.6%& 90.1%and 87.5%& 87.5%,respectively.The areas under ROC curve of the ACR of morning urine and random urine were 0.942±0.020 and 0.949±0.019,respectively(P>0.05).Conclusions: The random urine ACR is good correlation with 24 h UA,which can replace 24 h UA in screening and monitoring the early renal injury of type 2 diabetic patients.
2014, 39(8): 1113-1116.
Abstract:
Objective: To explore the diagnostic value of the combined detection of serum cancer antigen 125(CA125),carbohydrate antigen 242(CA242),carcinoembryonic antigen(CEA),cytokeratin 19 fragments(CYFRA21-1) and neuron specific enolase(NSE),tumor marker,in lung cancer.Methods: The biomarker levels of CA-125,CA242,CEA,CYFRA21-1 and NSE in 80 patients with lung cancer and 46 patients with benign lung disease were measured by the immunoluminometric assay.Results: The levels of CA-125,CA242,CEA,CYFRA21-1 and NSE in the patients with lung cancer were significantly higher than those in the patients with benign lung disease(P<0.01).The high levels of CEA,CA125 and CA242 in the patients with lung adenocarcinoma,squamous carcinoma and small cell lung cancer were found,respectively.The sensitivity of CYFRA21-1 in lung cancer was the highest,followed by CEA,CA125,NSE and CA242.The highest sensitivities of CYFRA21-1 in adenocarcinoma and squamous cell carcinoma were 50.00% and 48.94%,respectively.The sensitivities of CA125 and NSE in small cell lung cancer were the highest(48.15%).The areas under the ROC curve of CA125,CA242,CEA,CYFRA21-1 and NSE were 0.669±0.095,0.608±0.097,0.682±0.096,0.714±0.090 and 0.660±0.096,respectively.The sensitivity and specificity of the combined detection of CA125,CA242+CEA,CYFRA21-1 and NSE in the diagnosis of lung cancer were high and good(70.00% and 84.78%),respectively.The specificities of the CYFRA21-1 and CYFRA21-1 combined with other factors in the diagnosis of adenocarcinoma were the same(50.00%),but the Youden index of the latter was more than the former.The sensitivities of the combined detections of CA125,CA242,CEA and CYFRA21-1 in diagnosing squamous cell carcinoma and CA125,CA242+CEA,CYFRA21-1 and NSE in diagnosing small cell lung cancer were the highest,which were 72.34% and 88.89%,respectively.Conclusions: The single detection of CA125,CA242,CEA,CYFRA21-1 and NSE has certain significance in the diagnosis of lung cancer,but the sensitivity and specificity of which are limited.The combined detection of multi-markers can improve the sensitivity and specificity in diagnosing the lung cancer.
Objective: To explore the diagnostic value of the combined detection of serum cancer antigen 125(CA125),carbohydrate antigen 242(CA242),carcinoembryonic antigen(CEA),cytokeratin 19 fragments(CYFRA21-1) and neuron specific enolase(NSE),tumor marker,in lung cancer.Methods: The biomarker levels of CA-125,CA242,CEA,CYFRA21-1 and NSE in 80 patients with lung cancer and 46 patients with benign lung disease were measured by the immunoluminometric assay.Results: The levels of CA-125,CA242,CEA,CYFRA21-1 and NSE in the patients with lung cancer were significantly higher than those in the patients with benign lung disease(P<0.01).The high levels of CEA,CA125 and CA242 in the patients with lung adenocarcinoma,squamous carcinoma and small cell lung cancer were found,respectively.The sensitivity of CYFRA21-1 in lung cancer was the highest,followed by CEA,CA125,NSE and CA242.The highest sensitivities of CYFRA21-1 in adenocarcinoma and squamous cell carcinoma were 50.00% and 48.94%,respectively.The sensitivities of CA125 and NSE in small cell lung cancer were the highest(48.15%).The areas under the ROC curve of CA125,CA242,CEA,CYFRA21-1 and NSE were 0.669±0.095,0.608±0.097,0.682±0.096,0.714±0.090 and 0.660±0.096,respectively.The sensitivity and specificity of the combined detection of CA125,CA242+CEA,CYFRA21-1 and NSE in the diagnosis of lung cancer were high and good(70.00% and 84.78%),respectively.The specificities of the CYFRA21-1 and CYFRA21-1 combined with other factors in the diagnosis of adenocarcinoma were the same(50.00%),but the Youden index of the latter was more than the former.The sensitivities of the combined detections of CA125,CA242,CEA and CYFRA21-1 in diagnosing squamous cell carcinoma and CA125,CA242+CEA,CYFRA21-1 and NSE in diagnosing small cell lung cancer were the highest,which were 72.34% and 88.89%,respectively.Conclusions: The single detection of CA125,CA242,CEA,CYFRA21-1 and NSE has certain significance in the diagnosis of lung cancer,but the sensitivity and specificity of which are limited.The combined detection of multi-markers can improve the sensitivity and specificity in diagnosing the lung cancer.
2014, 39(8): 1117-1119.
Abstract:
Objective: To explore the effects of abnormal thyroid function on the pregnancy outcome.Methods: Three thousand seven hundred and seventy-eight pregnant women without the history of thyroid disease were divided into the hyperthyroidism group,hypothyreosis group,subclinical hypothyreosis group,other thyroid disease group and normal control group according to the thyroid function.The processes and outcomes of pregnancy between all groups were analyzed and compared.Results: The preterm delivery rates of the hyperthyroidism group,hypothyreosis group,subclinical hypothyreosis group and low thyroid group were significantly higher than that of the normal group(P<0.01).The incidence of adverse outcome in all groups were higher than that in normal control group(P<0.01).The differences of the neonatal 5 min Apgar scores between the hyperthyroidism group,hypothyreosis group,subclinical hypothyreosis group,low thyroid group and normal control group were not statistically significant(P>0.05),the neonatal weights in hyperthyroidism group and hypothyreosis group were lower than that in normal control group(P<0.01).The differences of the occurrence rates of respiratory distress syndrome,intrauterine growth retardation,hypertensive disorder complicating pregnancy and postpartum infection between pregnant with abnormal thyroid function and normal control group were statistically significant(P<0.01).The incidence of respiratory distress syndrome in hyperthyroidism group,hypothyreosis group and subclinical hypothyreosis group,and the incidence of hypertensive disorders in hyperthyroidism group and hypothyroidism group were higher than those in normal control group(P<0.01).Conclusions: The regular testing of FT3,FT4 and thyroid stimulating hormone is very helpful to know the thyroid function of pregnant,which can induce the complications and improve the pregnancy outcome.
Objective: To explore the effects of abnormal thyroid function on the pregnancy outcome.Methods: Three thousand seven hundred and seventy-eight pregnant women without the history of thyroid disease were divided into the hyperthyroidism group,hypothyreosis group,subclinical hypothyreosis group,other thyroid disease group and normal control group according to the thyroid function.The processes and outcomes of pregnancy between all groups were analyzed and compared.Results: The preterm delivery rates of the hyperthyroidism group,hypothyreosis group,subclinical hypothyreosis group and low thyroid group were significantly higher than that of the normal group(P<0.01).The incidence of adverse outcome in all groups were higher than that in normal control group(P<0.01).The differences of the neonatal 5 min Apgar scores between the hyperthyroidism group,hypothyreosis group,subclinical hypothyreosis group,low thyroid group and normal control group were not statistically significant(P>0.05),the neonatal weights in hyperthyroidism group and hypothyreosis group were lower than that in normal control group(P<0.01).The differences of the occurrence rates of respiratory distress syndrome,intrauterine growth retardation,hypertensive disorder complicating pregnancy and postpartum infection between pregnant with abnormal thyroid function and normal control group were statistically significant(P<0.01).The incidence of respiratory distress syndrome in hyperthyroidism group,hypothyreosis group and subclinical hypothyreosis group,and the incidence of hypertensive disorders in hyperthyroidism group and hypothyroidism group were higher than those in normal control group(P<0.01).Conclusions: The regular testing of FT3,FT4 and thyroid stimulating hormone is very helpful to know the thyroid function of pregnant,which can induce the complications and improve the pregnancy outcome.
2014, 39(8): 1120-1122.
Abstract:
Objective: To investigate the effects of nursing intervention on social factors cesarean section.Methods: Two hundred puerperas were randomly divided into the observation group and control group(100 cases each group).The control group were treated with the conventionally intrapartum nursing,the observation group were treated with nursing intervention measures according to its social factors.The nursing effects between two groups were compared.Results: The difference of the pre-natal childbirth way selected by puerpera and their family in two groups was not statistical significance(P>0.05).After nursing intervention,the cesarean delivery rate in observation group was significantly lower than that in control group(P<0.01).Conclusions: Nursing intervention can reduce maternal childbirth pain,social factors cesarean section and postpartum maternal complications,and improve the patient's trust and quality of obstetric service.
Objective: To investigate the effects of nursing intervention on social factors cesarean section.Methods: Two hundred puerperas were randomly divided into the observation group and control group(100 cases each group).The control group were treated with the conventionally intrapartum nursing,the observation group were treated with nursing intervention measures according to its social factors.The nursing effects between two groups were compared.Results: The difference of the pre-natal childbirth way selected by puerpera and their family in two groups was not statistical significance(P>0.05).After nursing intervention,the cesarean delivery rate in observation group was significantly lower than that in control group(P<0.01).Conclusions: Nursing intervention can reduce maternal childbirth pain,social factors cesarean section and postpartum maternal complications,and improve the patient's trust and quality of obstetric service.
2014, 39(8): 1123-1125.
Abstract:
Objective: To investigate the effect of the elderly frequently-hospitalized diabetic patients' health belief model on medical compliance behavior.Methods: Eighty-six elderly frequently-hospitalized diabetic patients were selected and randomly divided into observation group and control group.The observation group was educated by the health belief model and control group by the routine health mode.A comparison of the control of blood glucose and glycosylated hemoglobin,medical compliance behavior and rehospitalization rate between two groups was conducted when admission and after 6 months,respectively.Results: By comparison,there were statistically significant in fasting glucose,glycosylated hemoglobin and medical compliance behavior(P<0.01) between two groups of patients after 6 months.The rehospitalization rate of was 37.2% and was less than 60.5% of conrtol group(P<0.05).Conclusions: Health education by using health belief model can promote medical compliance behavior of the elderly frequently-hospitalized diabetic patients,enhance the treatment effect,and improve the living quality of patients.
Objective: To investigate the effect of the elderly frequently-hospitalized diabetic patients' health belief model on medical compliance behavior.Methods: Eighty-six elderly frequently-hospitalized diabetic patients were selected and randomly divided into observation group and control group.The observation group was educated by the health belief model and control group by the routine health mode.A comparison of the control of blood glucose and glycosylated hemoglobin,medical compliance behavior and rehospitalization rate between two groups was conducted when admission and after 6 months,respectively.Results: By comparison,there were statistically significant in fasting glucose,glycosylated hemoglobin and medical compliance behavior(P<0.01) between two groups of patients after 6 months.The rehospitalization rate of was 37.2% and was less than 60.5% of conrtol group(P<0.05).Conclusions: Health education by using health belief model can promote medical compliance behavior of the elderly frequently-hospitalized diabetic patients,enhance the treatment effect,and improve the living quality of patients.
2014, 39(8): 1126-1128.
Abstract:
Objective: To investigate the intervention effects of comfort care on the quality of life in patients with coronary stent implantation.Methods: Seventy-two patients with coronary heart disease were divided into the observation group and control group using the random number table method(36 cases each group).The conventional measures,which included admission assessment,condition observation,diet care and preoperative and postoperative preparation,in two groups were implemented,and the observation group were additionally treated with comfort care mode.The anxiety and depression before and after treatment,and the quality of life after treatment in two groups were evaluated.Results: The scores of postoperative physical function,psychological state,social relationship,independence,environment and overall quality of life in observation group were significantly higher than those in control group after operation(P<0.05).Compared with the control group,the scores of the anxiety and depression in observation group were significantly improved at 15 and 30 days after operation(P<0.05).Conclusions: Comfort care can relieve the anxiety and depression,and improve quality of life of patients with coronary stent implantation.
Objective: To investigate the intervention effects of comfort care on the quality of life in patients with coronary stent implantation.Methods: Seventy-two patients with coronary heart disease were divided into the observation group and control group using the random number table method(36 cases each group).The conventional measures,which included admission assessment,condition observation,diet care and preoperative and postoperative preparation,in two groups were implemented,and the observation group were additionally treated with comfort care mode.The anxiety and depression before and after treatment,and the quality of life after treatment in two groups were evaluated.Results: The scores of postoperative physical function,psychological state,social relationship,independence,environment and overall quality of life in observation group were significantly higher than those in control group after operation(P<0.05).Compared with the control group,the scores of the anxiety and depression in observation group were significantly improved at 15 and 30 days after operation(P<0.05).Conclusions: Comfort care can relieve the anxiety and depression,and improve quality of life of patients with coronary stent implantation.
2014, 39(8): 1129-1131.
Abstract:
Objective: To explore the effects of therapeutic communication on the anxiety and nursing satisfaction of hemodialysis patients during the induction period.Methods: Forty hemodialysis patients with anxiety in induction period were divided into the experimental group and control group(20 cases each group).The control group and experimental group were treated with general communication and therapeutic communication based on the general communication,respectively.The demographic characteristics and social culture of two groups were investigated,the levels of anxiety and satisfaction in two groups were evaluated before and after nursing.Results: The differences of the levels of anxiety and satisfaction in two groups were not statistical significance before intervention(P>0.05).The levels of anxiety and satisfaction after intervention in experimental group were lower and higher than those in before intervention,respectively(P<0.01).The levels of anxiety and satisfaction after intervention in control group were lower and higher than those in before intervention,respectively(P<0.01).The levels of anxiety and satisfaction in experimental group after intervention were lower and higher than those in control group,respectively(P<0.01).Conclusions: Therapeutic communication can relieve the anxiety of hemodialysis patients during the induction period,and increase the nursing satisfaction of patients.
Objective: To explore the effects of therapeutic communication on the anxiety and nursing satisfaction of hemodialysis patients during the induction period.Methods: Forty hemodialysis patients with anxiety in induction period were divided into the experimental group and control group(20 cases each group).The control group and experimental group were treated with general communication and therapeutic communication based on the general communication,respectively.The demographic characteristics and social culture of two groups were investigated,the levels of anxiety and satisfaction in two groups were evaluated before and after nursing.Results: The differences of the levels of anxiety and satisfaction in two groups were not statistical significance before intervention(P>0.05).The levels of anxiety and satisfaction after intervention in experimental group were lower and higher than those in before intervention,respectively(P<0.01).The levels of anxiety and satisfaction after intervention in control group were lower and higher than those in before intervention,respectively(P<0.01).The levels of anxiety and satisfaction in experimental group after intervention were lower and higher than those in control group,respectively(P<0.01).Conclusions: Therapeutic communication can relieve the anxiety of hemodialysis patients during the induction period,and increase the nursing satisfaction of patients.
2014, 39(8): 1132-1134.
Abstract:
Objective: To investigate the effects of clinical nursing path on the negative emotions and pain of patients with gout.Methods: Eighty-five cases with chronic joint pain caused by gout were randomly divided into the observation group 43 cases and control group 42 cases.The control group were treated with routine nursing,the observation group were treated with clinical nursing path based on routine nursing.The compliance.psychological status and pain between two groups were compared before and after intervention.Results: The compliance rate of the observation group after intervention was higher than that of the control group(P<0.01).The scores of Hamilton anxiety scale and Hamilton depressive scale in observation group after intervention were better than those in control group(P<0.01).The pain in observation group after intervention was significantly lower than that in control group(P<0.01).Conclusions: The clinical nursing path can effectively improve the negative emotions,and relieve the pain of patients,which is conducive to the prognosis of patients.
Objective: To investigate the effects of clinical nursing path on the negative emotions and pain of patients with gout.Methods: Eighty-five cases with chronic joint pain caused by gout were randomly divided into the observation group 43 cases and control group 42 cases.The control group were treated with routine nursing,the observation group were treated with clinical nursing path based on routine nursing.The compliance.psychological status and pain between two groups were compared before and after intervention.Results: The compliance rate of the observation group after intervention was higher than that of the control group(P<0.01).The scores of Hamilton anxiety scale and Hamilton depressive scale in observation group after intervention were better than those in control group(P<0.01).The pain in observation group after intervention was significantly lower than that in control group(P<0.01).Conclusions: The clinical nursing path can effectively improve the negative emotions,and relieve the pain of patients,which is conducive to the prognosis of patients.
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