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2015 Vol. 40, No. 5
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2015, 40(5): 561-563,568.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.001
Abstract:
Objective: To observe the changes of CD3+CD8+CD28- suppress T lymphocytes(Ts) and CD3+CD8+CD28+ cytotoxic T lymphocytes(Tc) subsets in peripheral blood of SD rats with spinal cord injury(SCI).Methods: The SCI model of ten female SD rats were established using New York University Spinal Cord Contusion system.The changes of CD3+CD8+CD28- and CD3+CD8+CD28+ T cell subsets in peripheral blood were evaluated using flow cytometry at the time points of pre-injury and days 1,3,5,7,14,21,28 and 56 post-injury.Results: The percentages of Ts and Tc in the CD3+ T cells of peripheral blood of healthy rats were(30.27±12.09)% and(14.75±4.29)%,respectively.The percentage of Ts was(22.58±12.12)% at the first day of SCI.At the 5th day,it decreased to the lowest level(20.86±10.41)%,it reached to the normal level from 7 to 21d after SCI.At 28th day,it increased to(37.90±12.98)%.At 56th day(33.79±11.44)%,it decreased to the normal level again(P>0.05).The change trend of Tc was opposite to the Ts after SCI.The percentages of Tc at time points of days 1,5,21 and 28 post-injury were(17.29±7.10)%,(20.02±6.24)%,(23.89±6.78)% and(13.81±11.21)%,respectively.It didn't return to normal level,but decreased to(8.71±6.44)% at the time points of 56 d(P<0.01).Conclusions: In the early stage of SCI,Tc are predominant in the peripheral blood of SD rats,which suggest that the function inhibition of Ts and enhancement of Tc may be one of the important immune injury mechanism of the SCI.The period from 5 to 21 days post-injury may be a key time window for the immunomodulatory treatment of SCI.
Objective: To observe the changes of CD3+CD8+CD28- suppress T lymphocytes(Ts) and CD3+CD8+CD28+ cytotoxic T lymphocytes(Tc) subsets in peripheral blood of SD rats with spinal cord injury(SCI).Methods: The SCI model of ten female SD rats were established using New York University Spinal Cord Contusion system.The changes of CD3+CD8+CD28- and CD3+CD8+CD28+ T cell subsets in peripheral blood were evaluated using flow cytometry at the time points of pre-injury and days 1,3,5,7,14,21,28 and 56 post-injury.Results: The percentages of Ts and Tc in the CD3+ T cells of peripheral blood of healthy rats were(30.27±12.09)% and(14.75±4.29)%,respectively.The percentage of Ts was(22.58±12.12)% at the first day of SCI.At the 5th day,it decreased to the lowest level(20.86±10.41)%,it reached to the normal level from 7 to 21d after SCI.At 28th day,it increased to(37.90±12.98)%.At 56th day(33.79±11.44)%,it decreased to the normal level again(P>0.05).The change trend of Tc was opposite to the Ts after SCI.The percentages of Tc at time points of days 1,5,21 and 28 post-injury were(17.29±7.10)%,(20.02±6.24)%,(23.89±6.78)% and(13.81±11.21)%,respectively.It didn't return to normal level,but decreased to(8.71±6.44)% at the time points of 56 d(P<0.01).Conclusions: In the early stage of SCI,Tc are predominant in the peripheral blood of SD rats,which suggest that the function inhibition of Ts and enhancement of Tc may be one of the important immune injury mechanism of the SCI.The period from 5 to 21 days post-injury may be a key time window for the immunomodulatory treatment of SCI.
2015, 40(5): 564-568.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.002
Abstract:
Objective: To construct the recombinant plasmid containing the osteopontin(OPN) gene and package lentivirus with it.Methods: The total RNA of kidney tissue was abstracted from C57BL/6 wild type mouse,and then was transcribed to cDNA.The OPN gene was largely amplified with special primers,and then cloned to lentivirus carrier to constract the pCDH-CMV-MCS-EF1-GFP-T2A-Puro.The lentivirus was packaged by transfecting the plasmids into 293T cells,and the virus titer was tested.Results: The OPN gene fragment was successfully cloned by sequencing.The virus titer was 2.5×108 TU/ml.Conclusions: The lentivirus containing OPN gene is successfully packaged,which lays the foundation in further researching the biological function of OPN gene.
Objective: To construct the recombinant plasmid containing the osteopontin(OPN) gene and package lentivirus with it.Methods: The total RNA of kidney tissue was abstracted from C57BL/6 wild type mouse,and then was transcribed to cDNA.The OPN gene was largely amplified with special primers,and then cloned to lentivirus carrier to constract the pCDH-CMV-MCS-EF1-GFP-T2A-Puro.The lentivirus was packaged by transfecting the plasmids into 293T cells,and the virus titer was tested.Results: The OPN gene fragment was successfully cloned by sequencing.The virus titer was 2.5×108 TU/ml.Conclusions: The lentivirus containing OPN gene is successfully packaged,which lays the foundation in further researching the biological function of OPN gene.
2015, 40(5): 569-571.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.003
Abstract:
Objective: To establisha method used for quantitative detecting the neuronal gap junction function.Methods: The primary neurons were cultured,the purity of neurons was identified by immunofluorescence.Two kinds of different molecular weight of fluorescent dyes Calcein and Dil were incubated with neurons for 30 min to make donor neurons,and then incubated with received neurons for 2.5 h.The number of received neurons around the donor neurons was observed with inverted fluorescence microscope.Results: The purity of cultured primary neurons reached 90%,which could be used to defect neurons gap junction function.The received neurons around the donor neurons could be clearly observed and counted.Conclusions: The fluorescent tracer method established in this experiment can be used for quantitative detecting the neuronal gap junction function.
Objective: To establisha method used for quantitative detecting the neuronal gap junction function.Methods: The primary neurons were cultured,the purity of neurons was identified by immunofluorescence.Two kinds of different molecular weight of fluorescent dyes Calcein and Dil were incubated with neurons for 30 min to make donor neurons,and then incubated with received neurons for 2.5 h.The number of received neurons around the donor neurons was observed with inverted fluorescence microscope.Results: The purity of cultured primary neurons reached 90%,which could be used to defect neurons gap junction function.The received neurons around the donor neurons could be clearly observed and counted.Conclusions: The fluorescent tracer method established in this experiment can be used for quantitative detecting the neuronal gap junction function.
2015, 40(5): 572-574.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.004
Abstract:
Objective: To investigate the expression of paired immunoglobulin-like receptor-B(PirB) in intracerebral haemorrhage(ICH) tissue of rat.Methods: The rats were randomly divided into the experimantal group and control group.The ICH rat model was established by injecting itself artery blood under brain stereotaxic appartatus.The PirB expressions in rat brain were detected using RT-PCR and Western blot.Results: Comparated with the control group,the PirB levels in the experimental group increased significantly(P<0.01).Conclusions: The PirB is concerned with the apoptosis process of the neuron in ICH tissue,which maybe be related to the nerve regeneration and inhibition of functional recovery.
Objective: To investigate the expression of paired immunoglobulin-like receptor-B(PirB) in intracerebral haemorrhage(ICH) tissue of rat.Methods: The rats were randomly divided into the experimantal group and control group.The ICH rat model was established by injecting itself artery blood under brain stereotaxic appartatus.The PirB expressions in rat brain were detected using RT-PCR and Western blot.Results: Comparated with the control group,the PirB levels in the experimental group increased significantly(P<0.01).Conclusions: The PirB is concerned with the apoptosis process of the neuron in ICH tissue,which maybe be related to the nerve regeneration and inhibition of functional recovery.
2015, 40(5): 575-577,581.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.005
Abstract:
Objective: To investigate the effect of rehabilitation with constraint-induced movement therapy(CIMT) at different times on neural function and observe the expression of nestin after middle cerebral artery occlusion in rat model.Methods: One hundred and sixty healthy male SD rats were randomly divided into 4 groups:normal group,sham operation group,model group and treatment group.The rats in each group were divided into 5 subgroups by 6 h,12 h,24 h,48 h and 72 h,8 rats in each group.The rats in treatment group were treated with rehabilitation with CIMT,while the rats in other groups were treated with normal feeding.The success rate of neurologic impairment scores was analyzed and the expression of nestin in cortical ischaemic lesion was observed by immuno-histochemical technique after 14 days.Results: After cerebral infarction for 6 to 72 h,the rats in normal and sham operation groups were no nerve defect performance at each time point,but the scores of nerve function defect in treatment group were lower than the scores in model group(P<0.05);there was no statistical significance of nerve function defect scores in model group and treatment group at 6 to 72 h interval time differently(P>0.05);the positive cell number of nestin in normal and sham operation groups was significantly less than that in model and treatment groups after cerebral infarction for 6 to 72 h(P<0.01),and the positive cell number in treatment group was significantly higher than that in other groups at different time points(P<0.01);there was no statistical significance of positive cell number at different time points among normal,sham operation and model groups(P>0.05);and the positive cell number of nestin after cerebral infarction for 24 h was higher than that at other time points in treatment group(P<0.05).Conclusions: The best time to do compulsory rehabilitation training was after cerebral infarction for 24 h in rat;the mechanism may be related to increase infarct peripheral nerve stem cell proliferation and differentiation.
Objective: To investigate the effect of rehabilitation with constraint-induced movement therapy(CIMT) at different times on neural function and observe the expression of nestin after middle cerebral artery occlusion in rat model.Methods: One hundred and sixty healthy male SD rats were randomly divided into 4 groups:normal group,sham operation group,model group and treatment group.The rats in each group were divided into 5 subgroups by 6 h,12 h,24 h,48 h and 72 h,8 rats in each group.The rats in treatment group were treated with rehabilitation with CIMT,while the rats in other groups were treated with normal feeding.The success rate of neurologic impairment scores was analyzed and the expression of nestin in cortical ischaemic lesion was observed by immuno-histochemical technique after 14 days.Results: After cerebral infarction for 6 to 72 h,the rats in normal and sham operation groups were no nerve defect performance at each time point,but the scores of nerve function defect in treatment group were lower than the scores in model group(P<0.05);there was no statistical significance of nerve function defect scores in model group and treatment group at 6 to 72 h interval time differently(P>0.05);the positive cell number of nestin in normal and sham operation groups was significantly less than that in model and treatment groups after cerebral infarction for 6 to 72 h(P<0.01),and the positive cell number in treatment group was significantly higher than that in other groups at different time points(P<0.01);there was no statistical significance of positive cell number at different time points among normal,sham operation and model groups(P>0.05);and the positive cell number of nestin after cerebral infarction for 24 h was higher than that at other time points in treatment group(P<0.05).Conclusions: The best time to do compulsory rehabilitation training was after cerebral infarction for 24 h in rat;the mechanism may be related to increase infarct peripheral nerve stem cell proliferation and differentiation.
2015, 40(5): 578-581.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.006
Abstract:
Objective: To investigate the relationships between cognitive function,depression,anxiety and BODE index(including body mass index,airflow obstruction,dyspnea and exercise capacity index) in patients with chronic obstructive pulmonary disease(COPD).Methods: In the cross-sectional study method,53 patients diagnosed as COPD were evaluated for cognitive function,depression,anxiety and BODE scores,49 normal health controls were evaluated for cognitive function,depression,anxiety scores.The differences of COPD group and control group in cognitive function and depression,anxiety were analyzed.The relationship between cognitive function and depression,anxiety and BODE index in COPD group were analyzed.Results: Compared with control group,cognitive function in COPD group decreased significantly(P<0.01)and the depression and anxiety scores of COPD group all increased significantly(P<0.01).Compared with COPD patients without cognitive impairment,the scores of depression,anxiety and BODE index of COPD patients with cognitive impairment all increased significantly(P<0.01).The cognitive function was negatively correlated with depression,anxiety and BODE index scores in COPD group(P<0.01)Conclusions: Cognitive function and depression,anxiety and BODE index in COPD group were closely related.
Objective: To investigate the relationships between cognitive function,depression,anxiety and BODE index(including body mass index,airflow obstruction,dyspnea and exercise capacity index) in patients with chronic obstructive pulmonary disease(COPD).Methods: In the cross-sectional study method,53 patients diagnosed as COPD were evaluated for cognitive function,depression,anxiety and BODE scores,49 normal health controls were evaluated for cognitive function,depression,anxiety scores.The differences of COPD group and control group in cognitive function and depression,anxiety were analyzed.The relationship between cognitive function and depression,anxiety and BODE index in COPD group were analyzed.Results: Compared with control group,cognitive function in COPD group decreased significantly(P<0.01)and the depression and anxiety scores of COPD group all increased significantly(P<0.01).Compared with COPD patients without cognitive impairment,the scores of depression,anxiety and BODE index of COPD patients with cognitive impairment all increased significantly(P<0.01).The cognitive function was negatively correlated with depression,anxiety and BODE index scores in COPD group(P<0.01)Conclusions: Cognitive function and depression,anxiety and BODE index in COPD group were closely related.
2015, 40(5): 582-586.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.007
Abstract:
Objective: To investigate the clinicopathological characteristics of the solid papillary renal cell carcinoma(sPRCC),and its differential diagnosis from mucinous tubular and spindle cell carcinoma(MTSC).Methods: Two sPRCC cases were investigated by light microscopy,special stains,immunohistochemistry,fluorescence in situ hybridization(FISH),and the literature was reviewed.Results: Two sPRCC patients were male,51 and 71 years old,the lumbago was their clinical manifestation.The tumor size of two cases were 2.0 cm and 3.5 cm,the cut surface of tumors were grayish-white,well-circumscribed,and local hemorrhage and necrosis.Histological examination of two tumors showed that the tumor cells were cuboidal or oval and arranged in tubular pattern,and the part cells tightly packed and arranged in solid sheet.The partial region tumor cells in 1 case arranged in beam,a small amount of papillary structures without vascular axis were found in tumor margin,and a small amount of slime and sand body calcification corpuscle were found in intercellular substance.Foam cell aggregation and mucous mesenchyme in intercellular substance were found in another case.The positive expressions of AMACR,Vimentin,EMA,CK7 and CK19 were found in two cases,and the Ki-67 was less than 5%.FISH showed that chromosomes 7 and 17 amplified,and chromosomes Y lost in two cases.Conclusions: The sPRCC is rare papillary renal cell carcinoma,the morphology and immunohistochemistry of which are similar with MTSC.The FISH examination can effectively identify the sPRCC from MTSC.
Objective: To investigate the clinicopathological characteristics of the solid papillary renal cell carcinoma(sPRCC),and its differential diagnosis from mucinous tubular and spindle cell carcinoma(MTSC).Methods: Two sPRCC cases were investigated by light microscopy,special stains,immunohistochemistry,fluorescence in situ hybridization(FISH),and the literature was reviewed.Results: Two sPRCC patients were male,51 and 71 years old,the lumbago was their clinical manifestation.The tumor size of two cases were 2.0 cm and 3.5 cm,the cut surface of tumors were grayish-white,well-circumscribed,and local hemorrhage and necrosis.Histological examination of two tumors showed that the tumor cells were cuboidal or oval and arranged in tubular pattern,and the part cells tightly packed and arranged in solid sheet.The partial region tumor cells in 1 case arranged in beam,a small amount of papillary structures without vascular axis were found in tumor margin,and a small amount of slime and sand body calcification corpuscle were found in intercellular substance.Foam cell aggregation and mucous mesenchyme in intercellular substance were found in another case.The positive expressions of AMACR,Vimentin,EMA,CK7 and CK19 were found in two cases,and the Ki-67 was less than 5%.FISH showed that chromosomes 7 and 17 amplified,and chromosomes Y lost in two cases.Conclusions: The sPRCC is rare papillary renal cell carcinoma,the morphology and immunohistochemistry of which are similar with MTSC.The FISH examination can effectively identify the sPRCC from MTSC.
2015, 40(5): 587-589.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.008
Abstract:
Objective: To investigate the expression of β-catenin and vascular endothelial growth factor-C(VEGF-C) in papillary thyroid carcinoma(PTC) and to analyze their clinical significance.Methods: The expression of β-catenin and VEGF-C in 70 PTC fissues and 40 normal thyroid tissues were detected by using immunohistochemistry method.Results: The ectopic expression of β-catenin and the positive expression of VEGF-C in PTC fissues were 70.00% and 75.71%,respectively;the ectopic expression of β-catenin and the positive expression f VEGF-C in normal thyroid tissues were 0 and 15.00%,respectively.The ectopic expression of β-catenin and the positive expression of VEGF-C were significantly higher in tumor tissues than in normal thyroid tissues(P<0.01);the ectopic expression of β-catenin and the positive expression of VEGF-C were significantly higher in metastatic tumors than in non-metastatic tumors(P<0.01);The ectopic expression of β-catenin was positively correlated with the expression of VEGF-C(P<0.01).Conclusions: β-catenin and VEGF-C in PTC may play an important role in the lymphangiogenesis of PTC.
Objective: To investigate the expression of β-catenin and vascular endothelial growth factor-C(VEGF-C) in papillary thyroid carcinoma(PTC) and to analyze their clinical significance.Methods: The expression of β-catenin and VEGF-C in 70 PTC fissues and 40 normal thyroid tissues were detected by using immunohistochemistry method.Results: The ectopic expression of β-catenin and the positive expression of VEGF-C in PTC fissues were 70.00% and 75.71%,respectively;the ectopic expression of β-catenin and the positive expression f VEGF-C in normal thyroid tissues were 0 and 15.00%,respectively.The ectopic expression of β-catenin and the positive expression of VEGF-C were significantly higher in tumor tissues than in normal thyroid tissues(P<0.01);the ectopic expression of β-catenin and the positive expression of VEGF-C were significantly higher in metastatic tumors than in non-metastatic tumors(P<0.01);The ectopic expression of β-catenin was positively correlated with the expression of VEGF-C(P<0.01).Conclusions: β-catenin and VEGF-C in PTC may play an important role in the lymphangiogenesis of PTC.
2015, 40(5): 590-592,595.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.009
Abstract:
Objective: To explore the clinical and imaging charteristics,pathological immunohistochemical features and differential diagnosis of hepatic focal nodular hyperplasia(FNH).Methods: Nine cases of hepatic FNH were analyzed by means of clinicopathologic data analysis,imaging features,histopathology,immunophenotype,cytokeratin 8/18 and cytokeratin 7,α-fetoprotein and Ki-67.In addition,the related literature was reviewed.Results: The imaging demonstrated a solitary nodular,and the plain scan showed isodensity or slightly low density with a low density scar in the centre.Hepatic FNH was a tumor presenting a clear realm and having a mass nodular fibrous scar in the centre.The liver tissue was divided into unequal and irregular nodules by the fibrous scar;thick wall vessels and proliferation of the bile ducts could be seen.Hepatic FNH showed positive immunostaining of cytokeratin 8/18 and cytokeratin 7 in the small bile ducts within the nodule and partial liver cells surrounding.CD34 was positively expressed on blood sinus endothelial cells of the nodules and fiber interval.Both the hyperplasia bile ducts and the liver cells were negative for α-fetoprotein and lowly expressed for Ki-67.Conclusions: FNH is widely recognized as a hyperplasia reaction of live cells to vascular malformations;therefore,hepatic FNH is a kind of benign tumor-like lesion.Asymptomatic persons with clear diagnosis should be followed-up regularly and reviewed after operation excision.
Objective: To explore the clinical and imaging charteristics,pathological immunohistochemical features and differential diagnosis of hepatic focal nodular hyperplasia(FNH).Methods: Nine cases of hepatic FNH were analyzed by means of clinicopathologic data analysis,imaging features,histopathology,immunophenotype,cytokeratin 8/18 and cytokeratin 7,α-fetoprotein and Ki-67.In addition,the related literature was reviewed.Results: The imaging demonstrated a solitary nodular,and the plain scan showed isodensity or slightly low density with a low density scar in the centre.Hepatic FNH was a tumor presenting a clear realm and having a mass nodular fibrous scar in the centre.The liver tissue was divided into unequal and irregular nodules by the fibrous scar;thick wall vessels and proliferation of the bile ducts could be seen.Hepatic FNH showed positive immunostaining of cytokeratin 8/18 and cytokeratin 7 in the small bile ducts within the nodule and partial liver cells surrounding.CD34 was positively expressed on blood sinus endothelial cells of the nodules and fiber interval.Both the hyperplasia bile ducts and the liver cells were negative for α-fetoprotein and lowly expressed for Ki-67.Conclusions: FNH is widely recognized as a hyperplasia reaction of live cells to vascular malformations;therefore,hepatic FNH is a kind of benign tumor-like lesion.Asymptomatic persons with clear diagnosis should be followed-up regularly and reviewed after operation excision.
2015, 40(5): 593-595.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.010
Abstract:
Objective: To investigate the relationship between red blood cell distribution width(RDW-CV) and heart rate variability(HRV) in patients with chronic heart failure(CHF).Methods: The RDW-CV and HRV in 80 patients with CHF(the observation group) and 80 normal old people(the control group) were compared.The RDW-CV and HRV in patiants with different New York Heart Association cardiac function class were observed,and the correlation of RDW-CV and HRV of which was analyzed.Results: The RDW-CV in observation group was higher than that in control group(P<0.01),the SDNN and SDANN in observation group were lower than those in control group(P<0.01).The RDW-CV in patients with cardiac function class Ⅲ-Ⅳ was significantly higher than that in patients with cardiac function class Ⅱ(P<0.01),and the standerd deviatian of the mean of all normal RR intervais within 24 h(SDNN)and standard deviation of the mean of all 5 minutes segments of normal RR intervals(SDANN)in patients with cardiac function class Ⅲ-Ⅳ were significantly lower than those in patients with cardiac function class Ⅱ(P<0.01).The RDW-CV was negatively correlated with the SDNN and SDANN in observation group(P<0.01).Conclusions: The RDW-CV in CHF patients is associated with autonomic nerve especially the excessive activation of sympathetic nerve.
Objective: To investigate the relationship between red blood cell distribution width(RDW-CV) and heart rate variability(HRV) in patients with chronic heart failure(CHF).Methods: The RDW-CV and HRV in 80 patients with CHF(the observation group) and 80 normal old people(the control group) were compared.The RDW-CV and HRV in patiants with different New York Heart Association cardiac function class were observed,and the correlation of RDW-CV and HRV of which was analyzed.Results: The RDW-CV in observation group was higher than that in control group(P<0.01),the SDNN and SDANN in observation group were lower than those in control group(P<0.01).The RDW-CV in patients with cardiac function class Ⅲ-Ⅳ was significantly higher than that in patients with cardiac function class Ⅱ(P<0.01),and the standerd deviatian of the mean of all normal RR intervais within 24 h(SDNN)and standard deviation of the mean of all 5 minutes segments of normal RR intervals(SDANN)in patients with cardiac function class Ⅲ-Ⅳ were significantly lower than those in patients with cardiac function class Ⅱ(P<0.01).The RDW-CV was negatively correlated with the SDNN and SDANN in observation group(P<0.01).Conclusions: The RDW-CV in CHF patients is associated with autonomic nerve especially the excessive activation of sympathetic nerve.
2015, 40(5): 596-598,601.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.011
Abstract:
Objective: To observe the effects of the modified rapid sequence induction combined with laryngeal mask airway(LMA) i-gel on the hemodynamics during induction period and surgical site grade in laparoscopic gallbladder surgery.Methods: Eighty laparoscopic cholecystectomy patients scheduled by laparoscopic gallbladder surgery were randomly divided into the modified rapid sequence induction group(group M)and conventional rapid induction(group C)(40 cases each group).The group M were induced with gradation dose combined without artificial positive pressure ventilation,the group C were induced with conventionally intravenous way.The arterial pressure and biochemical indexes in two groups were detected by radial artery puncture under local anesthesia before anesthesia induction.The speeds of the injection and transfusion were 1 ml/s and 10 ml·kg-1·h-1 in two groups,respectively.The heart rate,mean arterial pressure,pulse oxygen saturation,arterial blood oxygen partial pressure and arterial blood CO2 partial pressure of two groups were recorded at the time of pre-induction,post-induction 2 min,post-insertion LMA 1min and 5min,and the operation field was rated.Results: Compared with group C during induction,the hemodynamics of group M was stable.The fineness rate of the operation field grade in group M was higher than that in group C(P<0.05).Conclusions: Compared with the conventional rapid induction,the modified rapid sequence induction is stable hemodynamics and no lack of oxygen and carbon dioxide accumulation,which is suitable for induction in laparoscopic gallbladder surgery,can avoid the reflux,aspiration and gastrointestinal flatulence,and has a good prospect of clinical application.
Objective: To observe the effects of the modified rapid sequence induction combined with laryngeal mask airway(LMA) i-gel on the hemodynamics during induction period and surgical site grade in laparoscopic gallbladder surgery.Methods: Eighty laparoscopic cholecystectomy patients scheduled by laparoscopic gallbladder surgery were randomly divided into the modified rapid sequence induction group(group M)and conventional rapid induction(group C)(40 cases each group).The group M were induced with gradation dose combined without artificial positive pressure ventilation,the group C were induced with conventionally intravenous way.The arterial pressure and biochemical indexes in two groups were detected by radial artery puncture under local anesthesia before anesthesia induction.The speeds of the injection and transfusion were 1 ml/s and 10 ml·kg-1·h-1 in two groups,respectively.The heart rate,mean arterial pressure,pulse oxygen saturation,arterial blood oxygen partial pressure and arterial blood CO2 partial pressure of two groups were recorded at the time of pre-induction,post-induction 2 min,post-insertion LMA 1min and 5min,and the operation field was rated.Results: Compared with group C during induction,the hemodynamics of group M was stable.The fineness rate of the operation field grade in group M was higher than that in group C(P<0.05).Conclusions: Compared with the conventional rapid induction,the modified rapid sequence induction is stable hemodynamics and no lack of oxygen and carbon dioxide accumulation,which is suitable for induction in laparoscopic gallbladder surgery,can avoid the reflux,aspiration and gastrointestinal flatulence,and has a good prospect of clinical application.
2015, 40(5): 599-601.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.012
Abstract:
Objective: To explore the effects of sodium nitroprusside in the treatment of severe hand,foot and mouth disease(HFMD) complicated with hypertension.Methods: Thirty children with severe HFMD complicated with hypertension were treated with anti-virus,intravenous gamma globulin,methylprednisolone,mannitol and glycerol fructose.The sodium nitroprusside was additional used in all cases,the starting dose of which was 0.5 μg·kg-1·min-1.The dose of sodium nitroprusside was adjusted according to the blood pressure.The index changes were observed after 1 hour and 24 hours of treatment.Results: Compared before treatment,the hypertension in all cases after 1 hour and 24 hours of treatment were obviously decreased(P<0.01).Conclusions: Sodium nitroprusside can stabilize the blood pressure of the children with HFMD complicated with hypertension,which is effective and safe.
Objective: To explore the effects of sodium nitroprusside in the treatment of severe hand,foot and mouth disease(HFMD) complicated with hypertension.Methods: Thirty children with severe HFMD complicated with hypertension were treated with anti-virus,intravenous gamma globulin,methylprednisolone,mannitol and glycerol fructose.The sodium nitroprusside was additional used in all cases,the starting dose of which was 0.5 μg·kg-1·min-1.The dose of sodium nitroprusside was adjusted according to the blood pressure.The index changes were observed after 1 hour and 24 hours of treatment.Results: Compared before treatment,the hypertension in all cases after 1 hour and 24 hours of treatment were obviously decreased(P<0.01).Conclusions: Sodium nitroprusside can stabilize the blood pressure of the children with HFMD complicated with hypertension,which is effective and safe.
2015, 40(5): 602-605.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.013
Abstract:
Objective: To explore the clinical application of dexmedetomidine combined with nitroglycerin in minimally invasive resection of pituitary adenoma through nose,and assess its effectiveness,safety and practicality.Methods: Forty patients scheduled by minimally invasive resection of pituitary adenoma through nose were randomly divided into the D group and C group.The D group(dexmedetomidine group) were intravenously injected with a loading lose of dexmedetomidine(1 μg·kg-1·10 min-1) 10 min before anesthesia induction by micro-injection pump,following by a continuous infusion at a rate of 0.4 μg·kg-1·h-1,and the C group were injected with 0.9% sodium chloride injection in the same way.The mean arterial pressure of all patients were maintained for between 60 and 70 mmHg using nitroglycerin,and the propofol infusion speed was adjusted according to the bispectral index in order to maintain the bispectral index for between 40 to 50.The blood pressure and heart rate in all patients were observed,the intraoperative Fromme operative field quality score,operation time,blood loss,and average dose of propofol and nitroglycerin of all patients were recorded.The time of postoperative spontaneous breathing recovery,awakening and extubation were recorded.The ramsay sedation scores at extubation and after 1 h and 2 h of extubation,the occurrence of shivering and over-sedation within 2 h after extubation were also recorded.Results: Compared with the C group,less blood loss,lower Fromme score,short operation time and lower heart rate during the controlled hypotension period in D group were found(P<0.05 to P<0.01).Compared with the C group,the fluctuating of mean arterial pressure and heart rate and hemodynamics in D group were smaller and stabler at the moment of endotracheal intubation and extubation(P<0.01).The average dose of propofol and nitroglycerin in D group were significantly lower than those in C group(P<0.01).The differences of the time of awakening and extubation between two groups were not statistically significant(P>0.05).The Ramsay sedation scores at extubation and after 1 h of extubation in D group were higher and lower than that in C group,respectively(P<0.01).The difference of Ramsay sedation score between two groups after 2 h of extubation was not statistically significant(P>0.05).The incidence of shivering in D group was lower than that in C group C(P<0.05).Conclusions: The clinical application of dexmedetomidine combined with nitroglycerin in minimally invasive resection of pituitary adenoma through nose can significantly improve the operative score,shorten operation time,obtain better sedation effect and inhibit phenomenon of excessive sedation,which is effective,practicable and safe.
Objective: To explore the clinical application of dexmedetomidine combined with nitroglycerin in minimally invasive resection of pituitary adenoma through nose,and assess its effectiveness,safety and practicality.Methods: Forty patients scheduled by minimally invasive resection of pituitary adenoma through nose were randomly divided into the D group and C group.The D group(dexmedetomidine group) were intravenously injected with a loading lose of dexmedetomidine(1 μg·kg-1·10 min-1) 10 min before anesthesia induction by micro-injection pump,following by a continuous infusion at a rate of 0.4 μg·kg-1·h-1,and the C group were injected with 0.9% sodium chloride injection in the same way.The mean arterial pressure of all patients were maintained for between 60 and 70 mmHg using nitroglycerin,and the propofol infusion speed was adjusted according to the bispectral index in order to maintain the bispectral index for between 40 to 50.The blood pressure and heart rate in all patients were observed,the intraoperative Fromme operative field quality score,operation time,blood loss,and average dose of propofol and nitroglycerin of all patients were recorded.The time of postoperative spontaneous breathing recovery,awakening and extubation were recorded.The ramsay sedation scores at extubation and after 1 h and 2 h of extubation,the occurrence of shivering and over-sedation within 2 h after extubation were also recorded.Results: Compared with the C group,less blood loss,lower Fromme score,short operation time and lower heart rate during the controlled hypotension period in D group were found(P<0.05 to P<0.01).Compared with the C group,the fluctuating of mean arterial pressure and heart rate and hemodynamics in D group were smaller and stabler at the moment of endotracheal intubation and extubation(P<0.01).The average dose of propofol and nitroglycerin in D group were significantly lower than those in C group(P<0.01).The differences of the time of awakening and extubation between two groups were not statistically significant(P>0.05).The Ramsay sedation scores at extubation and after 1 h of extubation in D group were higher and lower than that in C group,respectively(P<0.01).The difference of Ramsay sedation score between two groups after 2 h of extubation was not statistically significant(P>0.05).The incidence of shivering in D group was lower than that in C group C(P<0.05).Conclusions: The clinical application of dexmedetomidine combined with nitroglycerin in minimally invasive resection of pituitary adenoma through nose can significantly improve the operative score,shorten operation time,obtain better sedation effect and inhibit phenomenon of excessive sedation,which is effective,practicable and safe.
2015, 40(5): 606-608,611.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.014
Abstract:
Objective: To explore the value of the early diastolic notch index of uterine artery in predicting hypertensive disorders complicating pregnancy(PIH).Methods: The bilateral uterine arteries in 204 single fetal pregnant women with normal delivery were detected using color doppler ultrasound.The women were divided into the notch group(21 cases) and non-notch group(183 cases) according to the notch in early diastolic uterine artery.The notch index(NI) in all cases were calculated,which was divided into 4 grades.The incidence of PIH and pregnancy outcome of each grade were compared.Results: Among 204 pregnant women,normal blood pressure in 188 cases and developing to PIH in 16 cases were found.The incidences of PIH in notch group and non-notch group were 28.6% and 5.5%,respectively,the difference of which was statistically significant(P<0.01).The incidences of PIH in NI 1 grade,NI 2 grade,NI 3 grade and NI 4 grade women were 5.4%,10.0%,2/6 and 3/4,respectively.The incidence of PIH in NI 4 grade women was higher than that in NI 1 grade and NI 2 grade women(P<0.01).The cesarean section rate in NI 4 group and incidence of neonatal 1 min Apgar score less than 7 in NI 3 and NI 4 group were higher than those in NI 1 group(P<0.05 to P<0.01).The placental weight of NI 3 and NI 4 group and newborn body quality in NI 2,3 and 4 group were lower than those in NI 1 group(P<0.05 to P<0.01).Conclusions: Early diastolic notch of uterine artery has high clinical value in predicting PIH.The classification of NI can well evaluate the incidence of PIH,which is worthy to be popularized.
Objective: To explore the value of the early diastolic notch index of uterine artery in predicting hypertensive disorders complicating pregnancy(PIH).Methods: The bilateral uterine arteries in 204 single fetal pregnant women with normal delivery were detected using color doppler ultrasound.The women were divided into the notch group(21 cases) and non-notch group(183 cases) according to the notch in early diastolic uterine artery.The notch index(NI) in all cases were calculated,which was divided into 4 grades.The incidence of PIH and pregnancy outcome of each grade were compared.Results: Among 204 pregnant women,normal blood pressure in 188 cases and developing to PIH in 16 cases were found.The incidences of PIH in notch group and non-notch group were 28.6% and 5.5%,respectively,the difference of which was statistically significant(P<0.01).The incidences of PIH in NI 1 grade,NI 2 grade,NI 3 grade and NI 4 grade women were 5.4%,10.0%,2/6 and 3/4,respectively.The incidence of PIH in NI 4 grade women was higher than that in NI 1 grade and NI 2 grade women(P<0.01).The cesarean section rate in NI 4 group and incidence of neonatal 1 min Apgar score less than 7 in NI 3 and NI 4 group were higher than those in NI 1 group(P<0.05 to P<0.01).The placental weight of NI 3 and NI 4 group and newborn body quality in NI 2,3 and 4 group were lower than those in NI 1 group(P<0.05 to P<0.01).Conclusions: Early diastolic notch of uterine artery has high clinical value in predicting PIH.The classification of NI can well evaluate the incidence of PIH,which is worthy to be popularized.
2015, 40(5): 609-611.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.015
Abstract:
Objective: To investigate the tracheotomy timing and its effects on prognosis in severe hypertensive intracerebral hemorrhage patients after operation.Methods: The patients with severe hypertensive intracerebral hemorrhage after operation(47 cases) were divided into the early cutting group(less than or equal to 24 h,25 cases) and non-early cutting group(more than 24 h,22 cases) according to the tracheotomy timing.The Glasgow coma score(GCS),pulmonary infection,incidence of hypoxemia and fatality rate between two groups were compared after 1 week of tracheotomy.Results: After 1 week of tracheotomy,the GCS in the early cutting group was higher than that in non-early cutting group(P<0.05),and the pulmonary infection,incidence of hypoxemia and fatality rate in the early cutting group were lower than those in non-early cutting group(P< 0.05 to P< 0.01).Conclusions: The early tracheotomy can significantly improve the prognosis,and reduce the fatality rate and incidence of pulmonary infection in postoperative patients with hypertensive cerebral hemorrhage.
Objective: To investigate the tracheotomy timing and its effects on prognosis in severe hypertensive intracerebral hemorrhage patients after operation.Methods: The patients with severe hypertensive intracerebral hemorrhage after operation(47 cases) were divided into the early cutting group(less than or equal to 24 h,25 cases) and non-early cutting group(more than 24 h,22 cases) according to the tracheotomy timing.The Glasgow coma score(GCS),pulmonary infection,incidence of hypoxemia and fatality rate between two groups were compared after 1 week of tracheotomy.Results: After 1 week of tracheotomy,the GCS in the early cutting group was higher than that in non-early cutting group(P<0.05),and the pulmonary infection,incidence of hypoxemia and fatality rate in the early cutting group were lower than those in non-early cutting group(P< 0.05 to P< 0.01).Conclusions: The early tracheotomy can significantly improve the prognosis,and reduce the fatality rate and incidence of pulmonary infection in postoperative patients with hypertensive cerebral hemorrhage.
2015, 40(5): 612-613.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.016
Abstract:
Objective: To summary the experience of rectal cancer resection under laparoscope with specimen out of the anus.Methods: The clinical data of rectal cancer resection under laparoscope with specimen out of the anus in 14 cases were analyzed.Results: All operations were successfully completed,no serious complications were found.All patients discharged at postoperative 5 to 8 days.No local recurrence or distant metastasis was found during the following up for 3 to 24 months.Conclusions: The rectal cancer resection under laparoscope with specimen out of the anus is small trauma and quack healing,which can achieve the goal of tumor treatment.
Objective: To summary the experience of rectal cancer resection under laparoscope with specimen out of the anus.Methods: The clinical data of rectal cancer resection under laparoscope with specimen out of the anus in 14 cases were analyzed.Results: All operations were successfully completed,no serious complications were found.All patients discharged at postoperative 5 to 8 days.No local recurrence or distant metastasis was found during the following up for 3 to 24 months.Conclusions: The rectal cancer resection under laparoscope with specimen out of the anus is small trauma and quack healing,which can achieve the goal of tumor treatment.
2015, 40(5): 614-616.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.017
Abstract:
Objective: To compare the clinical effects of the laparoscopic assisted vaginal hysterectomy(LAVH) and total abdominal hysterectomy(TAH),and investigate the LAVH clinical significance.Methods: Sixty-four patients treated with total hysterectomy were divided into LAVH and TAH group(32 cases each group) according to surgical method.The operation time,bleeding,postoperative temperature,anal exhaust time,hospital stay and analgesia pump use between two groups were compared.Results: The difference of uterine size between two groups was not statistically significant(P>0.05),the bleeding and operation time in LAVH group were higher than those in TAH group(P<0.01).The postoperative temperature,anal exhaust time,hospital stay and analgesia pump use in LAVH group were significantly lower than those in TAH group(P<0.05 to P<0.01).Conclusions: The two kinds of surgical methods have different advantages and disadvantages.LAVH is feasible,minimally invasive and beautiful,the postoperation of which is light pain,quick recovery and short hospital stay.
Objective: To compare the clinical effects of the laparoscopic assisted vaginal hysterectomy(LAVH) and total abdominal hysterectomy(TAH),and investigate the LAVH clinical significance.Methods: Sixty-four patients treated with total hysterectomy were divided into LAVH and TAH group(32 cases each group) according to surgical method.The operation time,bleeding,postoperative temperature,anal exhaust time,hospital stay and analgesia pump use between two groups were compared.Results: The difference of uterine size between two groups was not statistically significant(P>0.05),the bleeding and operation time in LAVH group were higher than those in TAH group(P<0.01).The postoperative temperature,anal exhaust time,hospital stay and analgesia pump use in LAVH group were significantly lower than those in TAH group(P<0.05 to P<0.01).Conclusions: The two kinds of surgical methods have different advantages and disadvantages.LAVH is feasible,minimally invasive and beautiful,the postoperation of which is light pain,quick recovery and short hospital stay.
2015, 40(5): 616-618.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.018
Abstract:
Objective: To investigate the clinical adverse reactions of high-dose methotrexate(HD-MTX) in the treatment of children with acute lymphoblastic leukemia(ALL).Methods: Forty cases of children with ALL were treated with HD-MTX(2.0-5.0 g/m2).The clinical signs and symptoms were observed and the incidence rates of adverse reactions were counted.Results: After three courses of treatment,some adverse reactions,such as,bone marrow suppression,gastrointestinal reactions,infection,liver injury,mucosal damage,heart damage,neurological symptoms,rash and alopecia appeared.The incidence rate of bone marrow suppression,gastrointestinal reactions,infection,liver injury,mucosal damage,heart damage,neurological symptoms,rash and alopecia was 61.3%,51.9%,38.1%,41.3%,15.6%,10.0%,15.0%,6.9% and 5.0%,respectively,but obvious renal injury did not appear.Conclusions: There were many adverse reactions of HD-MTX in the treatment of children with ALL,and it is important to carry out active symptomatic treatment,strengthen the monitoring of plasma concentrations of MTX and individualize treatment protocols,in order to increase the rate of long-term disease free survival.
Objective: To investigate the clinical adverse reactions of high-dose methotrexate(HD-MTX) in the treatment of children with acute lymphoblastic leukemia(ALL).Methods: Forty cases of children with ALL were treated with HD-MTX(2.0-5.0 g/m2).The clinical signs and symptoms were observed and the incidence rates of adverse reactions were counted.Results: After three courses of treatment,some adverse reactions,such as,bone marrow suppression,gastrointestinal reactions,infection,liver injury,mucosal damage,heart damage,neurological symptoms,rash and alopecia appeared.The incidence rate of bone marrow suppression,gastrointestinal reactions,infection,liver injury,mucosal damage,heart damage,neurological symptoms,rash and alopecia was 61.3%,51.9%,38.1%,41.3%,15.6%,10.0%,15.0%,6.9% and 5.0%,respectively,but obvious renal injury did not appear.Conclusions: There were many adverse reactions of HD-MTX in the treatment of children with ALL,and it is important to carry out active symptomatic treatment,strengthen the monitoring of plasma concentrations of MTX and individualize treatment protocols,in order to increase the rate of long-term disease free survival.
2015, 40(5): 619-621.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.019
Abstract:
Objective: To discuss the anesthesia effects of using sufentanil combined with propofol total intravenous anesthesia.Methods: Sixty patients with thoracic surgery were chosen and divided into two groups according to the random number method(30 cases in each group):the control group was given the traditional intravenous anesthesia;the observation group was given sufentanil 0.5~1.5 μg·kg-1·h-1 combined with propofol 3~5 mg·kg-1·h-1 venous continuous pump and 0.6 g·kg-1·min-1 of atracurium was used to keep muscle relaxan.The anesthesia effects and complications of the two groups were recorded and compared.Results: Heart rate of the two groups was declined at T1 compared with T0,and results showed that heart rate of the control group was higher than that of the observation group(P<0.01) from T2 to T5;systolic blood pressure(SBP) values of the control group were decreased at T1 compared with T0 while SBP values of the observation group were decreased at T3 compared with T0,and SBP values of the control group from T2 to T5 were higher than those of the observation group(P<0.01);at T4 SpO2 values of the two group were higher than at T0,SpO2 values of and the control group were higher than that of the observation group(P<0.01).In the control group the extubation time was(18.3±7.8) min,significantly longer than that in the observation group(12.8±6.9) min(P<0.01);Postoperative adverse reaction rate of the control group was 30.0% higher than that of the observation group 6.7%(P<0.05).Awakening period match rate in the observation group was 93.3% higher than that in the control group 80.0%(P<0.05).Conclusions: Using sufentanil combined with propofol has better anesthesia effects,also with shorter postoperative awake time and low incidence of adverse reactions,which is worthy of clinical promotion.
Objective: To discuss the anesthesia effects of using sufentanil combined with propofol total intravenous anesthesia.Methods: Sixty patients with thoracic surgery were chosen and divided into two groups according to the random number method(30 cases in each group):the control group was given the traditional intravenous anesthesia;the observation group was given sufentanil 0.5~1.5 μg·kg-1·h-1 combined with propofol 3~5 mg·kg-1·h-1 venous continuous pump and 0.6 g·kg-1·min-1 of atracurium was used to keep muscle relaxan.The anesthesia effects and complications of the two groups were recorded and compared.Results: Heart rate of the two groups was declined at T1 compared with T0,and results showed that heart rate of the control group was higher than that of the observation group(P<0.01) from T2 to T5;systolic blood pressure(SBP) values of the control group were decreased at T1 compared with T0 while SBP values of the observation group were decreased at T3 compared with T0,and SBP values of the control group from T2 to T5 were higher than those of the observation group(P<0.01);at T4 SpO2 values of the two group were higher than at T0,SpO2 values of and the control group were higher than that of the observation group(P<0.01).In the control group the extubation time was(18.3±7.8) min,significantly longer than that in the observation group(12.8±6.9) min(P<0.01);Postoperative adverse reaction rate of the control group was 30.0% higher than that of the observation group 6.7%(P<0.05).Awakening period match rate in the observation group was 93.3% higher than that in the control group 80.0%(P<0.05).Conclusions: Using sufentanil combined with propofol has better anesthesia effects,also with shorter postoperative awake time and low incidence of adverse reactions,which is worthy of clinical promotion.
2015, 40(5): 622-623,626.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.020
Abstract:
Objective: To explore the clinical effects of Montelukast in the treatment of cough-variant asthma in children.Methods: One hundred and five children with cough-variant asthma were randomly divided into the routine treatment group(56 cases) and Montelukast treatment group(49 cases).The routine treatment group were treated with inhaled corticosteroids for a long time,oral beta 2 receptor agonists for a short time combined with antiallergy,antitussive and expectotating phlegm,the Montelukast treatment group were treated with Montelukast(4 to 5 mg each time,once a day,by half after 3 months for 6 months) based on the routine treatment.The effects between two groups were compared after 2 weeks and 6 months of treatment.Results: After 2 weeks of treatment,the effective rate in Montelukast treatment group(71.43%) was higher than that in routine treatment group(50.00%)(P<0.01).After 6 months of treatment,the effective rate in Montelukast treatment group were 91.84%,which was significantly higher than that in routine treatment group(69.64%)(P<0.01),and no obvious adverse reaction was observed in Montelukast treatment group.Conclusions: Whether short-term or long-term oral treatment,Montelukast can obviously improve the treatment effects of cough-variant asthma in children,especial for the long-term treatment.
Objective: To explore the clinical effects of Montelukast in the treatment of cough-variant asthma in children.Methods: One hundred and five children with cough-variant asthma were randomly divided into the routine treatment group(56 cases) and Montelukast treatment group(49 cases).The routine treatment group were treated with inhaled corticosteroids for a long time,oral beta 2 receptor agonists for a short time combined with antiallergy,antitussive and expectotating phlegm,the Montelukast treatment group were treated with Montelukast(4 to 5 mg each time,once a day,by half after 3 months for 6 months) based on the routine treatment.The effects between two groups were compared after 2 weeks and 6 months of treatment.Results: After 2 weeks of treatment,the effective rate in Montelukast treatment group(71.43%) was higher than that in routine treatment group(50.00%)(P<0.01).After 6 months of treatment,the effective rate in Montelukast treatment group were 91.84%,which was significantly higher than that in routine treatment group(69.64%)(P<0.01),and no obvious adverse reaction was observed in Montelukast treatment group.Conclusions: Whether short-term or long-term oral treatment,Montelukast can obviously improve the treatment effects of cough-variant asthma in children,especial for the long-term treatment.
2015, 40(5): 624-626.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.021
Abstract:
Objective: To detect the change rules of T lymphocyte subsets in patients with severe craniocerebral injury to provide the basis in preventing infection by immunologic intervention.Methods: Thirty severe craniocerebral injury patients with glasgow coma score(GCS)≤8 and 30 light craniocerebral injury patients GCS =14 to 15 were divided into the observation group and control group,respectively.The expressions of lymphocyte subsets(including CD3,CD4,CD8,CD4/CD8 T) of peripheral blood in two groups after 1,3,7 d and 14 d of injury were detected using the immunofluorescent three-color flow cytometry.Results: Compared with the control group,the levels of CD3,CD4 and CD4/CD8 began to decrease,and the level of CD8 increased 1 d after injury in observation group.Compared with the control group,the levels of CD3,CD4 and CD4/CD8 decreased significantly,and the level of CD8 increased significantly 3 d after injury in observational group.The levels of lymphocyte subsets began to recover after 7 d of injury,and arrived at the normal level after 14 d of injury.The differences of the levels of lymphocyte subsets between two groups after 1 d,3 d and 7 d after injury were statistically significant(P<0.05 to P<0.01),and there was not statistical significance 14 d after injury(P>0.05).The lung infection rates in the observation group and control group after 4 d of injury were 73.3% and 0,respectively,the difference of which was statistically significant(P<0.01).Conclusions: Decreasing on day 1,significant decreasing on day 3,recovering on day 7 and arriving at the normal level on day 14 are the change rules of T lymphocyte subsets in severe craniocerebral injury patients.The immunologic intervention can be used to prevent infection in severe craniocerebral injury patients.
Objective: To detect the change rules of T lymphocyte subsets in patients with severe craniocerebral injury to provide the basis in preventing infection by immunologic intervention.Methods: Thirty severe craniocerebral injury patients with glasgow coma score(GCS)≤8 and 30 light craniocerebral injury patients GCS =14 to 15 were divided into the observation group and control group,respectively.The expressions of lymphocyte subsets(including CD3,CD4,CD8,CD4/CD8 T) of peripheral blood in two groups after 1,3,7 d and 14 d of injury were detected using the immunofluorescent three-color flow cytometry.Results: Compared with the control group,the levels of CD3,CD4 and CD4/CD8 began to decrease,and the level of CD8 increased 1 d after injury in observation group.Compared with the control group,the levels of CD3,CD4 and CD4/CD8 decreased significantly,and the level of CD8 increased significantly 3 d after injury in observational group.The levels of lymphocyte subsets began to recover after 7 d of injury,and arrived at the normal level after 14 d of injury.The differences of the levels of lymphocyte subsets between two groups after 1 d,3 d and 7 d after injury were statistically significant(P<0.05 to P<0.01),and there was not statistical significance 14 d after injury(P>0.05).The lung infection rates in the observation group and control group after 4 d of injury were 73.3% and 0,respectively,the difference of which was statistically significant(P<0.01).Conclusions: Decreasing on day 1,significant decreasing on day 3,recovering on day 7 and arriving at the normal level on day 14 are the change rules of T lymphocyte subsets in severe craniocerebral injury patients.The immunologic intervention can be used to prevent infection in severe craniocerebral injury patients.
2015, 40(5): 627-628.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.022
Abstract:
Objective: To explore the expression and clinical significance of CD4+ CD25+ regulatory T cells in patients with lung cancer.Methods: The expression of CD4+ CD25+ regulatory T cells in the peripheral blood of 42 patients with lung cancer(lung cancer group) and 15 healthy volunteers was determined by flow cytometry.Results: The number of CD4+ CD25+ regulatory T cells in the lung cancer group(7.17±3.63)% was significantly higher than that in the healthy controls(4.25±2.11)%(P<0.01).The level of CD4+ CD25+ regulatory T cells in the lung cancer patients with different pathological classifications had no statistically significant difference(P>0.05).The level of CD4+ CD25+ regulatory T cells in patients with advanced lung cancer was significantly higher than that in patients with early lung cancer(P<0.05).Conclusions: The proportion of CD4+ CD25+ regulatory T cells in the peripheral blood of patients with lung cancer is significantly increased,which is related to the progression of lung cancer.
Objective: To explore the expression and clinical significance of CD4+ CD25+ regulatory T cells in patients with lung cancer.Methods: The expression of CD4+ CD25+ regulatory T cells in the peripheral blood of 42 patients with lung cancer(lung cancer group) and 15 healthy volunteers was determined by flow cytometry.Results: The number of CD4+ CD25+ regulatory T cells in the lung cancer group(7.17±3.63)% was significantly higher than that in the healthy controls(4.25±2.11)%(P<0.01).The level of CD4+ CD25+ regulatory T cells in the lung cancer patients with different pathological classifications had no statistically significant difference(P>0.05).The level of CD4+ CD25+ regulatory T cells in patients with advanced lung cancer was significantly higher than that in patients with early lung cancer(P<0.05).Conclusions: The proportion of CD4+ CD25+ regulatory T cells in the peripheral blood of patients with lung cancer is significantly increased,which is related to the progression of lung cancer.
2015, 40(5): 629-632.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.023
Abstract:
Objective: To explore the correlation between the levels of the plasma lipoprotein(a)[Lp(a)],high sensitive C-reactive protein(hs-CRP) and brain natriuretic peptide(BNP) with the severity of coronary artery disease(CAD).Methods: According to the results of coronary angiography,216 patients were divided into the CAD group(216 cases) and control group(87 cases),and the CAD group were subdivided into the single-vessel disease group(35 cases),double-vessel disease group(40 cases) and three-vessel disease group(54 cases).The levels of the plasma Lp(a),hs-CRP and BNP in all groups were detected,and the correlations of whose with coronary lesion vessels and Gensini scores were analyzed.Results: The levels of Lp(a),hs-CRP and BNP in CAD group were significantly higher than those in control group(P<0.01).The differences of the levels of Lp(a),hs-CRP and BNP in different vessels disease group were statistically significant(P<0.01),and the levels of Lp(a),hs-CRP and BNP in three-vessel disease group were significantly higher than those in control group and single-vessel disease group(P<0.01).With the increasing of Gensini score,the levels of plasma Lp(a),hs-CRP and BNP increased(P<0.01).There was a positive correlation between the levels of Lp(a),hs-CRP and BNP with coronary lesion vessels and Gensini scores(P<0.01).Conclusions: The combined detection of the levels of plasma Lp(a),hs-CRP and BNP has an important significance in judging the severity of coronary artery disease.
Objective: To explore the correlation between the levels of the plasma lipoprotein(a)[Lp(a)],high sensitive C-reactive protein(hs-CRP) and brain natriuretic peptide(BNP) with the severity of coronary artery disease(CAD).Methods: According to the results of coronary angiography,216 patients were divided into the CAD group(216 cases) and control group(87 cases),and the CAD group were subdivided into the single-vessel disease group(35 cases),double-vessel disease group(40 cases) and three-vessel disease group(54 cases).The levels of the plasma Lp(a),hs-CRP and BNP in all groups were detected,and the correlations of whose with coronary lesion vessels and Gensini scores were analyzed.Results: The levels of Lp(a),hs-CRP and BNP in CAD group were significantly higher than those in control group(P<0.01).The differences of the levels of Lp(a),hs-CRP and BNP in different vessels disease group were statistically significant(P<0.01),and the levels of Lp(a),hs-CRP and BNP in three-vessel disease group were significantly higher than those in control group and single-vessel disease group(P<0.01).With the increasing of Gensini score,the levels of plasma Lp(a),hs-CRP and BNP increased(P<0.01).There was a positive correlation between the levels of Lp(a),hs-CRP and BNP with coronary lesion vessels and Gensini scores(P<0.01).Conclusions: The combined detection of the levels of plasma Lp(a),hs-CRP and BNP has an important significance in judging the severity of coronary artery disease.
2015, 40(5): 633-637.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.024
Abstract:
Objective: To investigate the relationship between gestational weight management and pregnancy outcome.Methods: The study of the relationship between gestational weight management and pregnancy outcome from 2004 to 2014 in CNKI,VIP database and wanfang database were searched,which was comprehensively quantitative analyzed using RevMan 5.0 version.Results: Fourteen articles about the relationship between gestational weight management and pregnancy outcome were heterogeneity tested and quantitatively analyzed using the fixed-effect model.The results showed that the gestational weight management can reduced the cesarean section,macrosomia and incidence of the gestational hypertensive disorders and diabetes.The OR value were 0.53(95%CI:0.46,0.61),0.29(95%CI:0.23,0.36) and 0.43(95%CI:0.33,0.58)and 0.29(95%CI:0.21,0.40) in turn.Conclusions: The gestational weight management can effectively reduced the cesarean section,macrosomia,and the incidence of the gestational hypertensive disorders and diabetes.
Objective: To investigate the relationship between gestational weight management and pregnancy outcome.Methods: The study of the relationship between gestational weight management and pregnancy outcome from 2004 to 2014 in CNKI,VIP database and wanfang database were searched,which was comprehensively quantitative analyzed using RevMan 5.0 version.Results: Fourteen articles about the relationship between gestational weight management and pregnancy outcome were heterogeneity tested and quantitatively analyzed using the fixed-effect model.The results showed that the gestational weight management can reduced the cesarean section,macrosomia and incidence of the gestational hypertensive disorders and diabetes.The OR value were 0.53(95%CI:0.46,0.61),0.29(95%CI:0.23,0.36) and 0.43(95%CI:0.33,0.58)and 0.29(95%CI:0.21,0.40) in turn.Conclusions: The gestational weight management can effectively reduced the cesarean section,macrosomia,and the incidence of the gestational hypertensive disorders and diabetes.
2015, 40(5): 650-655.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.030
Abstract:
Objective: To investigate the aggressive behavior and parental attachment in left-behind and non-left-behind senior pupils in north of Anhui province and their relationships.Methods: The general situation,aggressive behavior and parental attachment of the grade 4 to 6 rural elementary school left-behind children were investigated using stratified cluster random sampling.The relationship between children's aggressive behavior and parental attachment was analyzed using multiple linear regression.Results: The scores of the physical aggression behavior in left-behind boys with father or parents going out for work were higher than those in non-left-behind boys(P<0.05).The scores of the aggressive behavior in left-behind girls with parents going out for work were higher than that in non-left-behind girls and left-behind girls with single parents going out for work(P<0.05).The scores of the parental close dimensions in grade 4 were higher than those in grade 5 and 6 boys(P<0.01),and the scores of the parental close dimension in grade 4 and 5 were higher than those in grade 6 girls(P<0.05).The relationships between the aggressive behavior and parenal attachment dimension in left-behind children showed they were negative correlation(P< 0.05 to P<0.01).The trust dimension of mother-child attachment was the influencing factor of aggressive behavior in boys of non-left-behind and father unilateral wage,trust and close dimensions of father-child influencing factors of aggressive behavior in boys of mother unilateral wage,and trust dimensions of the parent-child were the influencing factor of aggressive behavior in left-behind boys.The trust dimension of mother-child was the influencing factor of aggressive behavior in the left-behind girls,the parent-child trust was the influencing factor of aggressive behavior in girls of mother unilateral wage,the three dimensions of the parent-child attachment and mother-child attachment were the influencing factor of aggressive behavior in girls of father unilateral wage,and the four dimensions of parent-child attachment all were the influencing factor of aggressive behavior in the left-behind children.Conclusions: The left-behind is the main factor of aggressive behavior in girls.The parental attachment has different effects on the aggressive behavior of different types of left-behind children.To establish a secure parental attachment relationship can effectively reduce the aggressive behavior of left-behind children.
Objective: To investigate the aggressive behavior and parental attachment in left-behind and non-left-behind senior pupils in north of Anhui province and their relationships.Methods: The general situation,aggressive behavior and parental attachment of the grade 4 to 6 rural elementary school left-behind children were investigated using stratified cluster random sampling.The relationship between children's aggressive behavior and parental attachment was analyzed using multiple linear regression.Results: The scores of the physical aggression behavior in left-behind boys with father or parents going out for work were higher than those in non-left-behind boys(P<0.05).The scores of the aggressive behavior in left-behind girls with parents going out for work were higher than that in non-left-behind girls and left-behind girls with single parents going out for work(P<0.05).The scores of the parental close dimensions in grade 4 were higher than those in grade 5 and 6 boys(P<0.01),and the scores of the parental close dimension in grade 4 and 5 were higher than those in grade 6 girls(P<0.05).The relationships between the aggressive behavior and parenal attachment dimension in left-behind children showed they were negative correlation(P< 0.05 to P<0.01).The trust dimension of mother-child attachment was the influencing factor of aggressive behavior in boys of non-left-behind and father unilateral wage,trust and close dimensions of father-child influencing factors of aggressive behavior in boys of mother unilateral wage,and trust dimensions of the parent-child were the influencing factor of aggressive behavior in left-behind boys.The trust dimension of mother-child was the influencing factor of aggressive behavior in the left-behind girls,the parent-child trust was the influencing factor of aggressive behavior in girls of mother unilateral wage,the three dimensions of the parent-child attachment and mother-child attachment were the influencing factor of aggressive behavior in girls of father unilateral wage,and the four dimensions of parent-child attachment all were the influencing factor of aggressive behavior in the left-behind children.Conclusions: The left-behind is the main factor of aggressive behavior in girls.The parental attachment has different effects on the aggressive behavior of different types of left-behind children.To establish a secure parental attachment relationship can effectively reduce the aggressive behavior of left-behind children.
2015, 40(5): 656-659.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.031
Abstract:
Objective: To analyze the relations between sub-health and physical exercise behavior in different gender medical students.Methods: Random sampling method was used to screen 338 medical students.The physical exercise behavior questionnaire included the length,frequency and intensity of exercises;the “SRHMS” scale included physical,psychological and social adaptation.Results: The boys' sub-health detection rate in physical,psychological,social adaptation and general health status were 43.4%,44.9%,41.2% and 41.2%,respectively,while the girls' were 54.5%,53.5%,48.5% and 52.0%,respectively.The difference was significant(P<0.05).Boys like long time,frequent and middle intensity exercises,while girls like medium time,medium frequent and middle intensity exercises.Students with low motion behavior had the highest sub-health detection rate,and students with moderate exercise behavior had the lowest detection rate.The difference was statistically significant(P<0.05).Conclusions: Sub-health is prevalent in medical college students.Girls have a higher sub-health rate than boys.Students with low exercise behavior are more prone to sub-health state.
Objective: To analyze the relations between sub-health and physical exercise behavior in different gender medical students.Methods: Random sampling method was used to screen 338 medical students.The physical exercise behavior questionnaire included the length,frequency and intensity of exercises;the “SRHMS” scale included physical,psychological and social adaptation.Results: The boys' sub-health detection rate in physical,psychological,social adaptation and general health status were 43.4%,44.9%,41.2% and 41.2%,respectively,while the girls' were 54.5%,53.5%,48.5% and 52.0%,respectively.The difference was significant(P<0.05).Boys like long time,frequent and middle intensity exercises,while girls like medium time,medium frequent and middle intensity exercises.Students with low motion behavior had the highest sub-health detection rate,and students with moderate exercise behavior had the lowest detection rate.The difference was statistically significant(P<0.05).Conclusions: Sub-health is prevalent in medical college students.Girls have a higher sub-health rate than boys.Students with low exercise behavior are more prone to sub-health state.
2015, 40(5): 659-661.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.032
Abstract:
Objective: To investigate the basic requirements of clinical skill of grassroot health post.Methods: The basic requirements of clinical skill in 225 students from Anhui Medical College during the internship period of grassroot health post were investigated.Results: The basic requirement rate of clinical skill on grassroot health post was more than 80%,the requirements included dressing technique(93.56%),debridement(90.59%),wearing/taking off gown/wearing sterile gloves(86.14%),urethral catheterization(83.17%),measuring children's physique growth(83.17%) and intaking oxygen/outptaking sputum technique(80.69%).This surgical basic skill training to meet the basic requirement of primary care has been implemented.Conclusions: Building the clinical skill training system according to the job demand and actual needs of grassroots health post can improve the quality of practical medical talent cultivation and construction of grassroot talent team.
Objective: To investigate the basic requirements of clinical skill of grassroot health post.Methods: The basic requirements of clinical skill in 225 students from Anhui Medical College during the internship period of grassroot health post were investigated.Results: The basic requirement rate of clinical skill on grassroot health post was more than 80%,the requirements included dressing technique(93.56%),debridement(90.59%),wearing/taking off gown/wearing sterile gloves(86.14%),urethral catheterization(83.17%),measuring children's physique growth(83.17%) and intaking oxygen/outptaking sputum technique(80.69%).This surgical basic skill training to meet the basic requirement of primary care has been implemented.Conclusions: Building the clinical skill training system according to the job demand and actual needs of grassroots health post can improve the quality of practical medical talent cultivation and construction of grassroot talent team.
2015, 40(5): 665-667.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.034
Abstract:
Objective: To investigate the clinical value of 3-D reconstruction of multi-slice spiral CT in the diagnosis of maxillary embedded teeth.Methods: The data of 16-slice spiral CT scan of embedded teeth with ambiguous location diagnosed by X-ray orthopantomography in 45 cases were imported into AW4.3 workstation,the volume rendering,maximum intensity projection,multi-planar reconstruction and curved planar reconstruction of teeth were analyzed.Results: Fifty-nine embedded teeth in 45 cases were found,which included 14 impacted teeth and 45 embedded supernumerary teeth.Conclusions: The profile and 3-D images of teeth can be observed by multi-slice spiral CT 3-D reconstruction technique,which can identify the number of embedded teeth,lip-palatal side position,direction of tooth form,and anatomical relationship with adjacent teeth,have great significance in pulling the embedded teeth and orthodontic treatment,and is worthy of further clinical application.
Objective: To investigate the clinical value of 3-D reconstruction of multi-slice spiral CT in the diagnosis of maxillary embedded teeth.Methods: The data of 16-slice spiral CT scan of embedded teeth with ambiguous location diagnosed by X-ray orthopantomography in 45 cases were imported into AW4.3 workstation,the volume rendering,maximum intensity projection,multi-planar reconstruction and curved planar reconstruction of teeth were analyzed.Results: Fifty-nine embedded teeth in 45 cases were found,which included 14 impacted teeth and 45 embedded supernumerary teeth.Conclusions: The profile and 3-D images of teeth can be observed by multi-slice spiral CT 3-D reconstruction technique,which can identify the number of embedded teeth,lip-palatal side position,direction of tooth form,and anatomical relationship with adjacent teeth,have great significance in pulling the embedded teeth and orthodontic treatment,and is worthy of further clinical application.
2015, 40(5): 668-669,675.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.035
Abstract:
Objective: To analyze the value of transvaginal ultrasound(TVS) in the diagnosis of cesarean scar pregnancy(CSP),and improve the accuracy and timeliness of TVS diagnosis.Methods: The TVS images of CSP in 32 patients were retrospectively analyzed,the influencing factors of the diagnosis accuracy rate of TVS were analyzed.Results: The accuracy rate of TVS in the diagnosis of CSP was 84.4%(27/32),the diagnostic accuracy rate of TVS in heterogeneous mass type and simple gestational sac type CSP were 100.0%(12/12) and 75.0%(15/20),respectively.Conclusions: Improving the TVS accuracy in the diagnosis of simple gestational sac type CSP is the key of improving the TVS accuracy in diagnosing CSP.The distance between gestational sac and uterine incision scar and knowledge of CSP ultrasound images are the main influencing factors of the diagnosis of simple gestational sac type CSP.
Objective: To analyze the value of transvaginal ultrasound(TVS) in the diagnosis of cesarean scar pregnancy(CSP),and improve the accuracy and timeliness of TVS diagnosis.Methods: The TVS images of CSP in 32 patients were retrospectively analyzed,the influencing factors of the diagnosis accuracy rate of TVS were analyzed.Results: The accuracy rate of TVS in the diagnosis of CSP was 84.4%(27/32),the diagnostic accuracy rate of TVS in heterogeneous mass type and simple gestational sac type CSP were 100.0%(12/12) and 75.0%(15/20),respectively.Conclusions: Improving the TVS accuracy in the diagnosis of simple gestational sac type CSP is the key of improving the TVS accuracy in diagnosing CSP.The distance between gestational sac and uterine incision scar and knowledge of CSP ultrasound images are the main influencing factors of the diagnosis of simple gestational sac type CSP.
2015, 40(5): 672-675.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.037
Abstract:
Objective: To investigate the correlations of quality of life with anxiety and depression in patients with leukemia.Methods: The quality of life,anxiety and depression in 56 patients with leukemia were investigated using the core quality of life questionnaire and hospital anxiety and depression scale.Results: Among 56 leukemia patients,20 cases with anxiety and 18 cases with depression were found.The scores of general health status,emotional and cognitive function in positive anxiety patients were lower than those in negative anxiety patients(P<0.05),but the scores of fatigue,pain and loss of appetite in positive anxiety patients were significantly high(P<0.01),and the differences of other factors scores between two groups were not statistically significant(P>0.05).The scores of general health status,and role,emotional,cognitive and social function in positive anxiety patients were lower than those in negative anxiety patients(P<0.05 to P<0.01),but the scores of fatigue,pain,shortness of breath,insomnia,loss of appetite and depression in positive anxiety patients were significantly high(P<0.05 to P<0.01),and the differences of other factors scores between two groups were not statistically significant(P>0.05).The anxiety and depression in leukemia patients were negatively correlated to the general health status,and role,emotional,cognitive and social function(P<0.05 to P<0.01),and positively correlated to fatigue,pain,shortness of breath,insomnia and appetite loss(P<0.05 to P<0.01),and uncorrelated to other factors(P>0.05).Conclusions: The incidences of anxiety and depression in patients with leukemia are high and their overall qualities of life are low,which can provide a reference in improving the quality of life of patient by improving their anxiety and depression.
Objective: To investigate the correlations of quality of life with anxiety and depression in patients with leukemia.Methods: The quality of life,anxiety and depression in 56 patients with leukemia were investigated using the core quality of life questionnaire and hospital anxiety and depression scale.Results: Among 56 leukemia patients,20 cases with anxiety and 18 cases with depression were found.The scores of general health status,emotional and cognitive function in positive anxiety patients were lower than those in negative anxiety patients(P<0.05),but the scores of fatigue,pain and loss of appetite in positive anxiety patients were significantly high(P<0.01),and the differences of other factors scores between two groups were not statistically significant(P>0.05).The scores of general health status,and role,emotional,cognitive and social function in positive anxiety patients were lower than those in negative anxiety patients(P<0.05 to P<0.01),but the scores of fatigue,pain,shortness of breath,insomnia,loss of appetite and depression in positive anxiety patients were significantly high(P<0.05 to P<0.01),and the differences of other factors scores between two groups were not statistically significant(P>0.05).The anxiety and depression in leukemia patients were negatively correlated to the general health status,and role,emotional,cognitive and social function(P<0.05 to P<0.01),and positively correlated to fatigue,pain,shortness of breath,insomnia and appetite loss(P<0.05 to P<0.01),and uncorrelated to other factors(P>0.05).Conclusions: The incidences of anxiety and depression in patients with leukemia are high and their overall qualities of life are low,which can provide a reference in improving the quality of life of patient by improving their anxiety and depression.
2015, 40(5): 676-678.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.038
Abstract:
Objective: To explore the application value of emergency care process in salvaging the patients with severe multiple trauma.Methods: Forty-five severe multiple trauma patients treated with conventional first aid methods from January 2012 to January 2013 and 58 cases treated with emergency care process from February 2013 to April 2014 were divided into the control group and observation group,respectively.The time of saving and blood using and rescue success rate between two groups were compared.Results: The saving time in observation group(56.77±2.33 min) was significantly shorter than that in control group(113.89±3.12 min)(P<0.01).The blood using time in control group(85.3±5.5 min) was significantly longer than that in observation group(42.2±3.1) min(P<0.01).The rescue success rate in observation group 96.6% and in control group 86.7% has no statistic difference(P>0.05).Conclusions: The emergency care process in salvaging the patients is effective,which has great clinical significance in saving life.
Objective: To explore the application value of emergency care process in salvaging the patients with severe multiple trauma.Methods: Forty-five severe multiple trauma patients treated with conventional first aid methods from January 2012 to January 2013 and 58 cases treated with emergency care process from February 2013 to April 2014 were divided into the control group and observation group,respectively.The time of saving and blood using and rescue success rate between two groups were compared.Results: The saving time in observation group(56.77±2.33 min) was significantly shorter than that in control group(113.89±3.12 min)(P<0.01).The blood using time in control group(85.3±5.5 min) was significantly longer than that in observation group(42.2±3.1) min(P<0.01).The rescue success rate in observation group 96.6% and in control group 86.7% has no statistic difference(P>0.05).Conclusions: The emergency care process in salvaging the patients is effective,which has great clinical significance in saving life.
2015, 40(5): 678-680.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.039
Abstract:
Objective: To explore the relevant factors affecting the implementation of hospice care and to analyze their sequence in weight so as to provide reference basis for the implementation of hospice care services in the compressive hospitals in Bengbu city.Methods: Interviews were conducted to the medical personnel of three compressive hospitals in Bengbu city.The influencing factors affecting the implementation of hospice care were analyzed by establishing theoretical models,using statistical software and by means of credibility,validity,correlation and multiple regressions;the sequencing of the factors was also conducted.Results: Professional talents,medical resources,modern life view and modern ethical view were the four factors positively correlated with the hospice care(P<0.01),the standardized regression coefficients being 0.456,0.244,0.125 and 0.075,respectively.Conclusions: The research reveals that four influencing factors were positively correlated with hospice care,and the sequences of them are as follows:professional talents,medical resources,modern life view and modern ethical view.
Objective: To explore the relevant factors affecting the implementation of hospice care and to analyze their sequence in weight so as to provide reference basis for the implementation of hospice care services in the compressive hospitals in Bengbu city.Methods: Interviews were conducted to the medical personnel of three compressive hospitals in Bengbu city.The influencing factors affecting the implementation of hospice care were analyzed by establishing theoretical models,using statistical software and by means of credibility,validity,correlation and multiple regressions;the sequencing of the factors was also conducted.Results: Professional talents,medical resources,modern life view and modern ethical view were the four factors positively correlated with the hospice care(P<0.01),the standardized regression coefficients being 0.456,0.244,0.125 and 0.075,respectively.Conclusions: The research reveals that four influencing factors were positively correlated with hospice care,and the sequences of them are as follows:professional talents,medical resources,modern life view and modern ethical view.
2015, 40(5): 681-684.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.040
Abstract:
Objective: To explore the effects of self-management on the patients with lumbar disc prolapse after traction therapy.Methods: One hundred and thirty-four patients with lumbar disc prolapse after traction therapy were randomly divided into the control group and intervention group(67cases each group).The control group were taught with conventional health,the intervention group were treated with self-management.The clinical symptoms and self-management levels in two groups were evaluated by questionnaire at seeing doctor after 3 and 6 months of seeing doctor.Results: The clinical symptoms of the patients treated with self-management were markedly improved.The scores of clinical symptoms and self-management abilities in intervention group were significantly higher than those in control group after 3 and 6 months of seeing doctor(P<0.05 to P<0.01).Conclusions: The treatment of the patients with lumbar disc prolapse with self-management can improve their self-management abilities and clinical symptoms.
Objective: To explore the effects of self-management on the patients with lumbar disc prolapse after traction therapy.Methods: One hundred and thirty-four patients with lumbar disc prolapse after traction therapy were randomly divided into the control group and intervention group(67cases each group).The control group were taught with conventional health,the intervention group were treated with self-management.The clinical symptoms and self-management levels in two groups were evaluated by questionnaire at seeing doctor after 3 and 6 months of seeing doctor.Results: The clinical symptoms of the patients treated with self-management were markedly improved.The scores of clinical symptoms and self-management abilities in intervention group were significantly higher than those in control group after 3 and 6 months of seeing doctor(P<0.05 to P<0.01).Conclusions: The treatment of the patients with lumbar disc prolapse with self-management can improve their self-management abilities and clinical symptoms.
2015, 40(5): 684-686.
doi: 10.13898/j.cnki.issn.1000-2200.2015.05.041
Abstract:
Objective: To explore the application effects of airbag midwifery in the stage of labor and its nursing method.Methods: One hundred and sixty-eight natural childbirth uniparas were randomly divided into the observation group and control group according to admission order(84 cases each group).The observation group were treated with airbag midwifery auxiliary childbirth,the control group were treated with conventional natural childbirth way.The labor,birth outcome and neonatal outcome between two groups were compared.Results: The first,second and total labor in observation group were significantly shorter than those in control group(P<0.01),the differences of the delivery mode and soft birth canal laceration between two groups were statistically significant(P<0.01 and P<0.05),the difference of the neonatal asphyxia rate between two groups was not statistically significant(P>0.05).Conclusions: Airbag midwifery can shorten the labor,reduce childbirth pain of puerpera,improve natural births,which is worthy of clinical promotion.
Objective: To explore the application effects of airbag midwifery in the stage of labor and its nursing method.Methods: One hundred and sixty-eight natural childbirth uniparas were randomly divided into the observation group and control group according to admission order(84 cases each group).The observation group were treated with airbag midwifery auxiliary childbirth,the control group were treated with conventional natural childbirth way.The labor,birth outcome and neonatal outcome between two groups were compared.Results: The first,second and total labor in observation group were significantly shorter than those in control group(P<0.01),the differences of the delivery mode and soft birth canal laceration between two groups were statistically significant(P<0.01 and P<0.05),the difference of the neonatal asphyxia rate between two groups was not statistically significant(P>0.05).Conclusions: Airbag midwifery can shorten the labor,reduce childbirth pain of puerpera,improve natural births,which is worthy of clinical promotion.
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