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2015 Vol. 40, No. 6
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2015, 40(6): 701-703,707.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.001
Abstract:
Objective:To detect the blood drug concentration of ginsenosides Rg1 in different feeding cycles by high performance liquid chromatography(HPLC) for determining the feeding cycle in the production of rabbit ginseng serum.Methods:The C18 column(4.6 mm×150 mm, 5 μm) was used, the Methanol-0.1% phosphate(60:40) was the mobile phase of ginsenosides Rg1, and the detection wave-length was 203 nm.Results:With the prolonging of feeding cycle, the blood drug concentration of ginsenosides Rg1 increased proportionally, the concentrations of 7 days, 14 days and 21 days were significantly higher than the concentrations of 3 days(P<0.01), the difference between 21 days and 14 days was not statistically significant(P>0.05).Conclusions:The HPLC is simple, accurate and reproducible, which can provide the experimental evidence in determining the feeding cycle of serum test, and effectively control the quality of ginseng.
Objective:To detect the blood drug concentration of ginsenosides Rg1 in different feeding cycles by high performance liquid chromatography(HPLC) for determining the feeding cycle in the production of rabbit ginseng serum.Methods:The C18 column(4.6 mm×150 mm, 5 μm) was used, the Methanol-0.1% phosphate(60:40) was the mobile phase of ginsenosides Rg1, and the detection wave-length was 203 nm.Results:With the prolonging of feeding cycle, the blood drug concentration of ginsenosides Rg1 increased proportionally, the concentrations of 7 days, 14 days and 21 days were significantly higher than the concentrations of 3 days(P<0.01), the difference between 21 days and 14 days was not statistically significant(P>0.05).Conclusions:The HPLC is simple, accurate and reproducible, which can provide the experimental evidence in determining the feeding cycle of serum test, and effectively control the quality of ginseng.
2015, 40(6): 704-707.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.002
Abstract:
Objective:To investigate the roles of the aberrant expressions of vascular endothelial growth factor(VEGF)-D and gene of phosphate and tension homology deleted on chromsome ten(PTEN) in breast cancer tissue and its clinical significance.Methods:The levels of VEGF-D and PTEN in 90 samples of breast invasive carcinoma tissue, and 20 samples of benign proliferative lesions were detected using immunohistochemical method, the results of which together with the clinical pathological parameters were analyzed.Results:The differences of the levels of VEGF-D and PTEN protein between breast cancer tissue and benign hyperplastic lesions tissue were statistically significant(P<0.01).The differences of the positive expression of VEGF-D protein in the patients with lymph nodes metastasis or without, and positive and negative expression of estrogen receptor were statistically significant(P=0.03 and P<0.05).The differences of the negative expression of VEGF-D protein in the patients with lymph nodes metastasis or without, and positive and negative expression of estrogen receptor were statistically significant(P<0.01).The level of VEGF-D protein was significantly negative correlation with PTEN in breast cancer tissue(P<0.01).Conclusions:The aberrant expressions of VEGF-D and PTEN are related to the invasion and metastasis of breast cancer.The expressions of VEGF-D and PTEN protein are correlative.
Objective:To investigate the roles of the aberrant expressions of vascular endothelial growth factor(VEGF)-D and gene of phosphate and tension homology deleted on chromsome ten(PTEN) in breast cancer tissue and its clinical significance.Methods:The levels of VEGF-D and PTEN in 90 samples of breast invasive carcinoma tissue, and 20 samples of benign proliferative lesions were detected using immunohistochemical method, the results of which together with the clinical pathological parameters were analyzed.Results:The differences of the levels of VEGF-D and PTEN protein between breast cancer tissue and benign hyperplastic lesions tissue were statistically significant(P<0.01).The differences of the positive expression of VEGF-D protein in the patients with lymph nodes metastasis or without, and positive and negative expression of estrogen receptor were statistically significant(P=0.03 and P<0.05).The differences of the negative expression of VEGF-D protein in the patients with lymph nodes metastasis or without, and positive and negative expression of estrogen receptor were statistically significant(P<0.01).The level of VEGF-D protein was significantly negative correlation with PTEN in breast cancer tissue(P<0.01).Conclusions:The aberrant expressions of VEGF-D and PTEN are related to the invasion and metastasis of breast cancer.The expressions of VEGF-D and PTEN protein are correlative.
2015, 40(6): 708-711.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.003
Abstract:
Objective:To investigate the effects of probucol combined with celecoxib on atherosclerosis in rats.Methods:Forty male SD rats were randomly divided into the normal group, model group, probucol group, celecoxib group and probucol combined with celecoxib group(8 rats each group).Normal group was fed with standard forage.Rat model with atherosclerosis was established, and treated with high lipid, Vitamin D3 plus balloon injury of endarterium.The probucol group, celecoxib group and probucol combined with celecoxib group were treated with oral gavage, respectively.After 12 weeks of drug intervention in all groups, the serum levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein-cholesterol(LDL-C) and high density lipoprotein-cholesterol(HDL-C) were detected, the levels of serum C-reactive protein(CRP) and Pentraxin3(PTX3) were determined by ELISA, and the pathomorphological changes of thoracic aorta were measured using HE staining and the thickness of arterial intima and media and thickness ratio of intima to media were calculated.Results:Compared with the normal group, the serum levels of TC, LDL-C and CRP in model group, probucol group, celecoxib group and probucol combined with celecoxib group significantly increased(P<0.01).Compared with the model group, the serum levels of TC, LDL-C, CRP and PTX3 in probucol group and probucol combined with celecoxib group significantly decreased(P<0.01).Compared with the normal group, the thickness of arterial intima and media, and thickness ratio of intima to media in probucol group, celecoxib group and probucol combined with celecoxib group significantly increased(P<0.01).Compared with the model group, the thickness of arterial intima and thickness ratio of intima to media significantly decreased and the thickness of arterial media significantly increased in probucol group, celecoxib group and probucol combined with celecoxib group(P<0.01).Conclusions:The combination use of probucol and celecoxib can significantly decreased the levels of serum lipids and inflammatory factors in rats with atherosclerosis, which has certain effects on anti-atherosclerosis.
Objective:To investigate the effects of probucol combined with celecoxib on atherosclerosis in rats.Methods:Forty male SD rats were randomly divided into the normal group, model group, probucol group, celecoxib group and probucol combined with celecoxib group(8 rats each group).Normal group was fed with standard forage.Rat model with atherosclerosis was established, and treated with high lipid, Vitamin D3 plus balloon injury of endarterium.The probucol group, celecoxib group and probucol combined with celecoxib group were treated with oral gavage, respectively.After 12 weeks of drug intervention in all groups, the serum levels of total cholesterol(TC), triglyceride(TG), low density lipoprotein-cholesterol(LDL-C) and high density lipoprotein-cholesterol(HDL-C) were detected, the levels of serum C-reactive protein(CRP) and Pentraxin3(PTX3) were determined by ELISA, and the pathomorphological changes of thoracic aorta were measured using HE staining and the thickness of arterial intima and media and thickness ratio of intima to media were calculated.Results:Compared with the normal group, the serum levels of TC, LDL-C and CRP in model group, probucol group, celecoxib group and probucol combined with celecoxib group significantly increased(P<0.01).Compared with the model group, the serum levels of TC, LDL-C, CRP and PTX3 in probucol group and probucol combined with celecoxib group significantly decreased(P<0.01).Compared with the normal group, the thickness of arterial intima and media, and thickness ratio of intima to media in probucol group, celecoxib group and probucol combined with celecoxib group significantly increased(P<0.01).Compared with the model group, the thickness of arterial intima and thickness ratio of intima to media significantly decreased and the thickness of arterial media significantly increased in probucol group, celecoxib group and probucol combined with celecoxib group(P<0.01).Conclusions:The combination use of probucol and celecoxib can significantly decreased the levels of serum lipids and inflammatory factors in rats with atherosclerosis, which has certain effects on anti-atherosclerosis.
2015, 40(6): 712-715.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.004
Abstract:
Objective:To investigate the effects of low dose of dexamethasone on CD11b+ Gr-1+ myeloid-derived suppressor cells(MDSCs) in septic mice induced by lipopolysaccharide(LPS).Methods:The septic mice model was established by the intraperitoneal injection of LPS in BALB/c mice.The mice were randomly divided into the normal control group(NC group), sepsis group(SE group) and sepsis combined with dexamethasone group(SD group).The levels of serum interferon-γ and interleukin-10 were detected at 6, 12 and 24 hours.The percentage of CD11b+ Gr-1+ MDSCs in spleen and bone marrow of mice were detected at 12, 24, 48 and 72 hours.Results:Compared with the NC group, the levels of interferon-γ at 6 hours and interleukin-10 at 12 hours in SE group and SD group increased significantly(P<0.05 to P<0.01), and the difference of which between SE group and SD group was not statistically different (P<0.05).Compared with the NC group, the percentages of MDSCs in spleen at 12 to 72 hours in SE group and at 12 to 48 hours in SD group increased significantly (P<0.01), and the differences of the percentage of MDSCs at 24 to 72 hours between SE group and SD group were statistically different (P<0.05).Compared with the NC group, the percentages of MDSCs in bone marrow of SE and SD group increased significantly at 48 hours and 72 hours (P<0.05 to P<0.01).the differences of which at 48 and 72 hours between SE and SD groups were statistically significant(P<0.05 and P<0.01).Conclusions:Low dose of dexamethasone can inhibit the production and accumulation of MDSCs in septic mice induced by LPS.
Objective:To investigate the effects of low dose of dexamethasone on CD11b+ Gr-1+ myeloid-derived suppressor cells(MDSCs) in septic mice induced by lipopolysaccharide(LPS).Methods:The septic mice model was established by the intraperitoneal injection of LPS in BALB/c mice.The mice were randomly divided into the normal control group(NC group), sepsis group(SE group) and sepsis combined with dexamethasone group(SD group).The levels of serum interferon-γ and interleukin-10 were detected at 6, 12 and 24 hours.The percentage of CD11b+ Gr-1+ MDSCs in spleen and bone marrow of mice were detected at 12, 24, 48 and 72 hours.Results:Compared with the NC group, the levels of interferon-γ at 6 hours and interleukin-10 at 12 hours in SE group and SD group increased significantly(P<0.05 to P<0.01), and the difference of which between SE group and SD group was not statistically different (P<0.05).Compared with the NC group, the percentages of MDSCs in spleen at 12 to 72 hours in SE group and at 12 to 48 hours in SD group increased significantly (P<0.01), and the differences of the percentage of MDSCs at 24 to 72 hours between SE group and SD group were statistically different (P<0.05).Compared with the NC group, the percentages of MDSCs in bone marrow of SE and SD group increased significantly at 48 hours and 72 hours (P<0.05 to P<0.01).the differences of which at 48 and 72 hours between SE and SD groups were statistically significant(P<0.05 and P<0.01).Conclusions:Low dose of dexamethasone can inhibit the production and accumulation of MDSCs in septic mice induced by LPS.
2015, 40(6): 716-718.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.005
Abstract:
Objective:To investigate the effects of different doses of perfluorooctanoic acid(PFOA) on the spleen lipid peroxidation damage of mice.Methods:Forty SPF ICR mice were divided into the control group, and low(1 mg /kg), medium(5 mg /kg) and high dose(25 mg /kg) PFOA groups(10 mice each group) using the simple random sampling method.All mice were administered by gavage for 14 days.The mice were weighed every day, and their behavior were observed.The spleen/body weight indexes were calculated after 14 days.The activities of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px), sorbitol dehydrogenase(SDH), lactate dehydrogenase(LDH), and the levels of malondialdehyde(MDA), nitric oxide(NO) were analyzed.Results:The body weight of mice treated with PFOA grew slowly or lightened, especially in middle and high dose group(P<0.01).The spleen/body weight indexes of mice treated with PFOA were significantly lighter than that in control group(P<0.05).Compared with control group, the levels of MDA NO and LDH increased, the activities of SOD, GSH-Px and SDH in mice treated with PFOA decreased obviously, respectively(P<0.01).Conclusions:PFOA can inhibit the body weight growth of mice, and induce the spleen lipid peroxidation damage.
Objective:To investigate the effects of different doses of perfluorooctanoic acid(PFOA) on the spleen lipid peroxidation damage of mice.Methods:Forty SPF ICR mice were divided into the control group, and low(1 mg /kg), medium(5 mg /kg) and high dose(25 mg /kg) PFOA groups(10 mice each group) using the simple random sampling method.All mice were administered by gavage for 14 days.The mice were weighed every day, and their behavior were observed.The spleen/body weight indexes were calculated after 14 days.The activities of superoxide dismutase(SOD), glutathione peroxidase(GSH-Px), sorbitol dehydrogenase(SDH), lactate dehydrogenase(LDH), and the levels of malondialdehyde(MDA), nitric oxide(NO) were analyzed.Results:The body weight of mice treated with PFOA grew slowly or lightened, especially in middle and high dose group(P<0.01).The spleen/body weight indexes of mice treated with PFOA were significantly lighter than that in control group(P<0.05).Compared with control group, the levels of MDA NO and LDH increased, the activities of SOD, GSH-Px and SDH in mice treated with PFOA decreased obviously, respectively(P<0.01).Conclusions:PFOA can inhibit the body weight growth of mice, and induce the spleen lipid peroxidation damage.
2015, 40(6): 719-721.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.006
Abstract:
Objective:To explore the clinical significance of brainstem auditory evoked potential(BAEP) in the diagnosis and prognosis of transient ischemic attack of vertebral basilar artery system(VBTIA).Methods:The BAEPs of patients with VBTIA were monitored.The peak latency(PL) value of Ⅰ to Ⅴ wave and(or) interpeak latency(IPL) values of Ⅰ to Ⅲ wave, Ⅲ to Ⅴ wave and Ⅰ to Ⅴ wave, and the ratio of PL to IPL were observed.Results:The differences of the PL, IPL and abnormal rate of Ⅰ to Ⅲ/Ⅲ to Ⅴ between two groups were not statistically significant(P>0.05).The values of PL and IPL of BAEP in VBT group were significantly lower than those in posterior circulation cerebral infarction(P<0.01).Conclusions:BAEP can be used as the auxiliary examination in early diagnosis of VBTIA.The PL value of Ⅰ to Ⅴ wave and(or) the IPL values of Ⅰ to Ⅲ wave, Ⅲ to Ⅴ wave and Ⅰ to Ⅴ wave, and the ratio of PL to IPL are the main indicators, and the patients with abnormal indicators can easily transform into cerebral infarction.
Objective:To explore the clinical significance of brainstem auditory evoked potential(BAEP) in the diagnosis and prognosis of transient ischemic attack of vertebral basilar artery system(VBTIA).Methods:The BAEPs of patients with VBTIA were monitored.The peak latency(PL) value of Ⅰ to Ⅴ wave and(or) interpeak latency(IPL) values of Ⅰ to Ⅲ wave, Ⅲ to Ⅴ wave and Ⅰ to Ⅴ wave, and the ratio of PL to IPL were observed.Results:The differences of the PL, IPL and abnormal rate of Ⅰ to Ⅲ/Ⅲ to Ⅴ between two groups were not statistically significant(P>0.05).The values of PL and IPL of BAEP in VBT group were significantly lower than those in posterior circulation cerebral infarction(P<0.01).Conclusions:BAEP can be used as the auxiliary examination in early diagnosis of VBTIA.The PL value of Ⅰ to Ⅴ wave and(or) the IPL values of Ⅰ to Ⅲ wave, Ⅲ to Ⅴ wave and Ⅰ to Ⅴ wave, and the ratio of PL to IPL are the main indicators, and the patients with abnormal indicators can easily transform into cerebral infarction.
2015, 40(6): 721-722,726.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.007
Abstract:
Objective:To investigate the clinical application value of single utility hole video-assisted thoracoscopic operation in the treatment of spontaneous pneumothorax.Methods:Fifty-five patients with spontaneous pneumothorax were treated with single utility hole video-assisted thoracoscopic operation(observation group, 33 cases) and three utility holes video-assisted thoracoscopic operation(control group, 23 cases), respectively.The operation time, bleeding volume, operation cost, and postoperative extubation time and complications between two groups were compared.Results:The bleeding volume and operation cost of observation group were lower than the control group(P<0.05), the differences of the operation time, postoperative extubation time and complications between two groups were not statistically significant(P>0.05 to P=1.000).Conclusions:The single utility hole video-assisted thoracoscopic operation is single, and do not increase the operation time, which is consistent with the concept of minimally invasive, and worth promoting in minimally invasive thoracic surgery.
Objective:To investigate the clinical application value of single utility hole video-assisted thoracoscopic operation in the treatment of spontaneous pneumothorax.Methods:Fifty-five patients with spontaneous pneumothorax were treated with single utility hole video-assisted thoracoscopic operation(observation group, 33 cases) and three utility holes video-assisted thoracoscopic operation(control group, 23 cases), respectively.The operation time, bleeding volume, operation cost, and postoperative extubation time and complications between two groups were compared.Results:The bleeding volume and operation cost of observation group were lower than the control group(P<0.05), the differences of the operation time, postoperative extubation time and complications between two groups were not statistically significant(P>0.05 to P=1.000).Conclusions:The single utility hole video-assisted thoracoscopic operation is single, and do not increase the operation time, which is consistent with the concept of minimally invasive, and worth promoting in minimally invasive thoracic surgery.
2015, 40(6): 723-726.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.008
Abstract:
Objective:To evaluate the curative effects of "Drum Dance" on elderly patients with type 2 diabetes.Methods:Forty participants were randomly divided into the intervention and control group, two groups were treated with drug and diet control.The intervention group were additionally trained with aerobic exercise prescription of "Drum Dance" for 12 weeks(3 times a week, aerobic exercise intensity for 50% to 70% of maximum heart rate and 50 to 60 min every time).Results:The reduction of fasting blood glucose, cholesterol, low density lipoprotein, upper arm, abdomen, shoulder, sebum thickness, waist girth, hip girth and body mass index in intervention group after intervention were significantly higher than those in control group(P<0.05).Conclusions:The "Drum Dance" exercise intervention in the treatment of type 2 diabetes is a simple, safe and effective, which should promote and advocate in the urban and rural communities and improve the quality of life in elderly patients with type 2 diabetes.
Objective:To evaluate the curative effects of "Drum Dance" on elderly patients with type 2 diabetes.Methods:Forty participants were randomly divided into the intervention and control group, two groups were treated with drug and diet control.The intervention group were additionally trained with aerobic exercise prescription of "Drum Dance" for 12 weeks(3 times a week, aerobic exercise intensity for 50% to 70% of maximum heart rate and 50 to 60 min every time).Results:The reduction of fasting blood glucose, cholesterol, low density lipoprotein, upper arm, abdomen, shoulder, sebum thickness, waist girth, hip girth and body mass index in intervention group after intervention were significantly higher than those in control group(P<0.05).Conclusions:The "Drum Dance" exercise intervention in the treatment of type 2 diabetes is a simple, safe and effective, which should promote and advocate in the urban and rural communities and improve the quality of life in elderly patients with type 2 diabetes.
2015, 40(6): 727-729.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.009
Abstract:
Objective:To explore the effects of valsartan combined with folic acid in the treatment of elderly patients with type H hypertension complicated with high homocysteine.Methods:Three hundred patients with type H hypertension were randomly divided into the control group and treatment group.The control group were treated with 80 mg of valsartan once a day by oral, the treatment group were additionally treated with 0.4 mg of folic acid once a day by oral based on the control group.Two groups were treated for 12 months, the levels of blood pressure and homocysteine, and cardio-cerebrovascular events in two groups were observed before and after treatment.Results:Compared with before treatment, the blood pressure levels in two groups decreased significantly after 3, 6 and 12 months of treatment(P<0.01), but the difference of the hypotensive effects between two groups was not statistically significant(P>0.05).The homocysteine level and incidence of transient ischemic attack in treatment group were significantly lower than those in control group after 3, 6 and 12 months of treatment(P<0.01).Conclusions:The effects of valsartan combined with folic acid in the treatment of the elderly patients with type H hypertension are good, which can decrease the levels of the blood pressure and homocysteine, and occurrence of transient ischemic attack at the same time.
Objective:To explore the effects of valsartan combined with folic acid in the treatment of elderly patients with type H hypertension complicated with high homocysteine.Methods:Three hundred patients with type H hypertension were randomly divided into the control group and treatment group.The control group were treated with 80 mg of valsartan once a day by oral, the treatment group were additionally treated with 0.4 mg of folic acid once a day by oral based on the control group.Two groups were treated for 12 months, the levels of blood pressure and homocysteine, and cardio-cerebrovascular events in two groups were observed before and after treatment.Results:Compared with before treatment, the blood pressure levels in two groups decreased significantly after 3, 6 and 12 months of treatment(P<0.01), but the difference of the hypotensive effects between two groups was not statistically significant(P>0.05).The homocysteine level and incidence of transient ischemic attack in treatment group were significantly lower than those in control group after 3, 6 and 12 months of treatment(P<0.01).Conclusions:The effects of valsartan combined with folic acid in the treatment of the elderly patients with type H hypertension are good, which can decrease the levels of the blood pressure and homocysteine, and occurrence of transient ischemic attack at the same time.
2015, 40(6): 730-733.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.010
Abstract:
Objective:To evaluate the safety and efficacy of dexmedetomidine combined with dyclonine hydrochloride mucilage before general anesthesia in preventing agitation during the recovery period of laparoscopic cholecystectomy.Methods:Eighty patients treated with electively laparoscopic cholecystectomy were randomly divided into the normal saline group(group Ⅰ), dyclonine group(group Ⅱ), dexmedetomidine group(group Ⅲ) and dexmedetomidine combined with dyclonine group(group Ⅳ).The premedication didn't be used in all patients.Group Ⅲ and Ⅳ were treated with a loading dose of dexmedetomidine(0.6μg·kg-1·h-1) by intravenous infusion before anesthesia induction.After 15 min, the dose of dexmedetomidine revised by 0.2 to 0.3μg·kg-1·h-1.The position between the top of the tracheal tube and 15 cm was evenly covered by dyclonine hydrochloride mucilage in group Ⅱ and Ⅳ, group Ⅰ and Ⅱ were injected with saline infusion.The mean arterial pressure(MAP) and heart rate(HR) in all groups were recorded after operation(T1), tracheal extubation(T2) and 5 min after extubation(T3).The time of recovery and extubation, Riker sedation score before extubation and Ramsay sedation score after 5 min of extubation in four groups were observed.Results:Compared with the T1, the MAP and HR in group Ⅰand group Ⅱ were significantly higher at T2 and T3(P<0.01).The MAP and HR in group Ⅲ and group Ⅳ were lower than those in group Ⅰ at T1 and T3(P<0.05 to P<0.01).The differences of the recovery and extubation time in four groups were not statistically different(P>0.05).The Ramsay sedation score in group Ⅳ was significantly higher than that in other three groups(P<0.01).The Riker sedation-agitation scores in group Ⅱ, Ⅲ and Ⅳ were significantly lower than those in group Ⅰ(P<0.01).The incidence of agitation in group Ⅲ and Ⅳ were significantly lower than that in group Ⅰ(P<0.05).Conclusions:The treatment of a loading dose of dexmedetomidine(0.6μg·kg-1·h-1) and 0.2 to 0.3μg·kg-1·h-1 after 15 min before extubation combined with dyclonine hydrochloride mucilage can effectively prevent agitation of laparoscopic cholecystectomy patients during recovery period, reduce cardiovascular reaction during extubation and not prolong the recovery and extubation time.
Objective:To evaluate the safety and efficacy of dexmedetomidine combined with dyclonine hydrochloride mucilage before general anesthesia in preventing agitation during the recovery period of laparoscopic cholecystectomy.Methods:Eighty patients treated with electively laparoscopic cholecystectomy were randomly divided into the normal saline group(group Ⅰ), dyclonine group(group Ⅱ), dexmedetomidine group(group Ⅲ) and dexmedetomidine combined with dyclonine group(group Ⅳ).The premedication didn't be used in all patients.Group Ⅲ and Ⅳ were treated with a loading dose of dexmedetomidine(0.6μg·kg-1·h-1) by intravenous infusion before anesthesia induction.After 15 min, the dose of dexmedetomidine revised by 0.2 to 0.3μg·kg-1·h-1.The position between the top of the tracheal tube and 15 cm was evenly covered by dyclonine hydrochloride mucilage in group Ⅱ and Ⅳ, group Ⅰ and Ⅱ were injected with saline infusion.The mean arterial pressure(MAP) and heart rate(HR) in all groups were recorded after operation(T1), tracheal extubation(T2) and 5 min after extubation(T3).The time of recovery and extubation, Riker sedation score before extubation and Ramsay sedation score after 5 min of extubation in four groups were observed.Results:Compared with the T1, the MAP and HR in group Ⅰand group Ⅱ were significantly higher at T2 and T3(P<0.01).The MAP and HR in group Ⅲ and group Ⅳ were lower than those in group Ⅰ at T1 and T3(P<0.05 to P<0.01).The differences of the recovery and extubation time in four groups were not statistically different(P>0.05).The Ramsay sedation score in group Ⅳ was significantly higher than that in other three groups(P<0.01).The Riker sedation-agitation scores in group Ⅱ, Ⅲ and Ⅳ were significantly lower than those in group Ⅰ(P<0.01).The incidence of agitation in group Ⅲ and Ⅳ were significantly lower than that in group Ⅰ(P<0.05).Conclusions:The treatment of a loading dose of dexmedetomidine(0.6μg·kg-1·h-1) and 0.2 to 0.3μg·kg-1·h-1 after 15 min before extubation combined with dyclonine hydrochloride mucilage can effectively prevent agitation of laparoscopic cholecystectomy patients during recovery period, reduce cardiovascular reaction during extubation and not prolong the recovery and extubation time.
2015, 40(6): 734-737.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.011
Abstract:
Objective:To observe the effects of intraoperative autotransfusion on the inflammatory reaction, coagulation function and other complications of spine surgery patients.Methods:Sixty spine surgery patients, whose haemorrhage amount was expected to more than 600 ml, were randomly divided into the autotransfusion group(group A) and allogeneic transfusion group(group B) using a random number table(30 cases in each group).Arterial blood gas analysis, coagulation function and the levels of interleukin-6 and -10(IL-6 and -10) detected by radioimmunoassay in two groups were recorded before transfusion, after 1 h(T2), 24 h(T3), 48 h(T4) and 72 h(T5) of transfusion.The postoperative infection, wound healing and hospitalization days in two groups were observed after operation.Results:The levels of IL-6 and IL-10 in group A at T2 to T5 were significantly lower than those in group B(P<0.01).The differences of Hemoglobin and coagulation function after transfusion between two groups were not statistically significant(P>0.05).Compared with group B, no postoperative transfusion complication, good wound healing and short hospitalization days were found in group A(P<0.01).Conclusions:The intraoperative autotransfusion can obviously reduce the levels of IL-6 and IL-10 and postoperative complication, and promote rapid recovery in spine surgery patients.
Objective:To observe the effects of intraoperative autotransfusion on the inflammatory reaction, coagulation function and other complications of spine surgery patients.Methods:Sixty spine surgery patients, whose haemorrhage amount was expected to more than 600 ml, were randomly divided into the autotransfusion group(group A) and allogeneic transfusion group(group B) using a random number table(30 cases in each group).Arterial blood gas analysis, coagulation function and the levels of interleukin-6 and -10(IL-6 and -10) detected by radioimmunoassay in two groups were recorded before transfusion, after 1 h(T2), 24 h(T3), 48 h(T4) and 72 h(T5) of transfusion.The postoperative infection, wound healing and hospitalization days in two groups were observed after operation.Results:The levels of IL-6 and IL-10 in group A at T2 to T5 were significantly lower than those in group B(P<0.01).The differences of Hemoglobin and coagulation function after transfusion between two groups were not statistically significant(P>0.05).Compared with group B, no postoperative transfusion complication, good wound healing and short hospitalization days were found in group A(P<0.01).Conclusions:The intraoperative autotransfusion can obviously reduce the levels of IL-6 and IL-10 and postoperative complication, and promote rapid recovery in spine surgery patients.
2015, 40(6): 737-739.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.012
Abstract:
Objective:To summarize the experiences of the application of diret nipple ureteroneocystostomy in 10 adults with congenital megaureter(CM).Methods:Among 10 cases with CM(11 sides), unilateral CM in 9 cases and bilateral CM in 1 case were found.All cases were treated with ureteroneocystostomy after1.5 to 2.0 cm evaginating papillae of terminal ureter.Results:All cases were followed up for 3 months to 10 years, the postoperative hydronephrosis in 10 cases(11 sides) improved or disappeared, their ureteral profiles improved or recovered.Conclusions:The imaging examination was the major diagnostic criteria of CM in adult.The ureter was cut back according to different caliber of CM.The 1.5 to 2.0 cm evaginating papillae of terminal ureter and ureteroneocystostomy can play an effective role on preventing urine reflux and anastomotic stricture.
Objective:To summarize the experiences of the application of diret nipple ureteroneocystostomy in 10 adults with congenital megaureter(CM).Methods:Among 10 cases with CM(11 sides), unilateral CM in 9 cases and bilateral CM in 1 case were found.All cases were treated with ureteroneocystostomy after1.5 to 2.0 cm evaginating papillae of terminal ureter.Results:All cases were followed up for 3 months to 10 years, the postoperative hydronephrosis in 10 cases(11 sides) improved or disappeared, their ureteral profiles improved or recovered.Conclusions:The imaging examination was the major diagnostic criteria of CM in adult.The ureter was cut back according to different caliber of CM.The 1.5 to 2.0 cm evaginating papillae of terminal ureter and ureteroneocystostomy can play an effective role on preventing urine reflux and anastomotic stricture.
2015, 40(6): 740-743.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.013
Abstract:
Objective:To explore the levels of IL-6, IL-8 and IL-10 in serum and bronchoalveolar lavage fluid(BALF) of patients with community-acquired pneumonia(CAP), and its clinical significance.Methods:The clinical pulmonary infection score of 50 patients with CAP were detected on the first day after admission.The patients with CPIS less than 6 and equal to or more than 6 were divided into the light group and severe group, respectively.Ten healthy people were set as the control group.The levels of IL-6, IL-8 and IL-10 in serum and BALF of the patients with CAP were determined by radioimmunoassay on the first day after admission.The levels of IL-6, IL-8 and IL-10 in serum of the patients with CAP were also measured on day 7 and 30 of admission.Results:The levels of IL-6, IL-8 and IL-10 in serum and BALF of CAP patients were significantly higher than those in control group on the first day after admission(P<0.05 to P<0.01).The levels of IL-6 and IL-10 in serum and levels of IL-6, IL-8, IL-10 in BALF in severe CAP group were significantly higher in light CAP patients(P<0.01).With the disease course prolonging, the levels of IL-6 and IL-10 decreased(P<0.01), which arrived at the level of the control group on day 7 and 30 of admission(P>0.05).The level of IL-8 in serum of CAP patients remained at a high level on day 30 of admission, which was significantly higher than that in control group(P<0.01).Conclusions:The IL-6, IL-8 and IL-10 were involved in the pathogenesis of community-acquired pneumonia.The levels of IL-6 and IL-10 in serum and levels of IL-6, IL-8 and IL-10 in BALF can reflect the severity of pulmonary infection.The detection of IL-6, IL-8 and IL-10 in serum has certain clinical value in the early diagnosis of CAP.
Objective:To explore the levels of IL-6, IL-8 and IL-10 in serum and bronchoalveolar lavage fluid(BALF) of patients with community-acquired pneumonia(CAP), and its clinical significance.Methods:The clinical pulmonary infection score of 50 patients with CAP were detected on the first day after admission.The patients with CPIS less than 6 and equal to or more than 6 were divided into the light group and severe group, respectively.Ten healthy people were set as the control group.The levels of IL-6, IL-8 and IL-10 in serum and BALF of the patients with CAP were determined by radioimmunoassay on the first day after admission.The levels of IL-6, IL-8 and IL-10 in serum of the patients with CAP were also measured on day 7 and 30 of admission.Results:The levels of IL-6, IL-8 and IL-10 in serum and BALF of CAP patients were significantly higher than those in control group on the first day after admission(P<0.05 to P<0.01).The levels of IL-6 and IL-10 in serum and levels of IL-6, IL-8, IL-10 in BALF in severe CAP group were significantly higher in light CAP patients(P<0.01).With the disease course prolonging, the levels of IL-6 and IL-10 decreased(P<0.01), which arrived at the level of the control group on day 7 and 30 of admission(P>0.05).The level of IL-8 in serum of CAP patients remained at a high level on day 30 of admission, which was significantly higher than that in control group(P<0.01).Conclusions:The IL-6, IL-8 and IL-10 were involved in the pathogenesis of community-acquired pneumonia.The levels of IL-6 and IL-10 in serum and levels of IL-6, IL-8 and IL-10 in BALF can reflect the severity of pulmonary infection.The detection of IL-6, IL-8 and IL-10 in serum has certain clinical value in the early diagnosis of CAP.
2015, 40(6): 743-745.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.014
Abstract:
Objective:To explore the curative effects and clinical safety of rosuvastatin calcium combined with clopidogrel in the treatment of unstable angina pectoris(UAP).Methods:One hundred and twelve patients with UAP were divided into the control group(44 cases) and observation group(68 cases) according to different therapeutic methods.The control group and observation group were treated with low molecular heparin, aspirin, angiotensin converting enzyme inhibitors, nitrates and beta blockers and rosuvastatin calcium combined with clopidogrel based on the control group treatment, respectively.The clinical curative effects, safety, blood lipid level and adverse reactions in two groups were monitored.Results:The total effective rate in observation group(94.1%) was higher than that in control group(81.8%) (P<0.05).The effective rate of electrocardiogram improvement in observation group(92.6%) was significantly higher than that in control group(77.3%) (P<0.01).The difference of the blood lipid level between two groups before treatment was not statistically significant (P>0.05), the blood lipid level in observation group after treatment was improved(P<0.01), and the difference of the blood lipid level between two groups after treatment was statistically significant (P<0.01).The incidences of adverse reactions in control group and observation group were 2.9% and 13.6%, respectively, the difference of which was not statistically significant (P>0.05).During the following-up period, the angina recurrence rate in observation group were lower than those in controll group(P<0.05).Conclusions:On the basis of conventional treatment, the rosuvastatin calcium combined with clopidogrel in the treatment of unstable angina pectoris has good effects and high safety, which is worthy of clinical application.
Objective:To explore the curative effects and clinical safety of rosuvastatin calcium combined with clopidogrel in the treatment of unstable angina pectoris(UAP).Methods:One hundred and twelve patients with UAP were divided into the control group(44 cases) and observation group(68 cases) according to different therapeutic methods.The control group and observation group were treated with low molecular heparin, aspirin, angiotensin converting enzyme inhibitors, nitrates and beta blockers and rosuvastatin calcium combined with clopidogrel based on the control group treatment, respectively.The clinical curative effects, safety, blood lipid level and adverse reactions in two groups were monitored.Results:The total effective rate in observation group(94.1%) was higher than that in control group(81.8%) (P<0.05).The effective rate of electrocardiogram improvement in observation group(92.6%) was significantly higher than that in control group(77.3%) (P<0.01).The difference of the blood lipid level between two groups before treatment was not statistically significant (P>0.05), the blood lipid level in observation group after treatment was improved(P<0.01), and the difference of the blood lipid level between two groups after treatment was statistically significant (P<0.01).The incidences of adverse reactions in control group and observation group were 2.9% and 13.6%, respectively, the difference of which was not statistically significant (P>0.05).During the following-up period, the angina recurrence rate in observation group were lower than those in controll group(P<0.05).Conclusions:On the basis of conventional treatment, the rosuvastatin calcium combined with clopidogrel in the treatment of unstable angina pectoris has good effects and high safety, which is worthy of clinical application.
2015, 40(6): 746-748.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.015
Abstract:
Objective:To explore the effects of different doses of atorvastatin on the cardiac function and lipid in the patients with coronary heart disease after coronary artery bypass grafting(CABG).Methods:Sixty patients with coronary artery disease scheduled by CABG were randomly divided into the intensive treatment group(40 mg/d) and conventional treatment group(20 mg/d) according to the dose of atorvastatn before and after the surgery(30 cases each group).The blood lipid level and echocardiographic finding between two groups were compared before and after surgery, and the adverse reactions in two groups were recorded during treatment.Results:After treatment, the reduction of total cholesterol, triglyceride and low-density lipoprotein-cholesterol and increasing degree of high-density lipoprotein-cholesterol in intensive treatment group were better than those in conventional treatment group(P<0.05 to P<0.01).After treatment, the reduction of left ventricular end systolic volume index, left ventricular end-diastolic volume index and A peak and increasing degree of E peak, E/A and left ventricular ejection fraction in intensive treatment group were better than those in conventional treatment group(P<0.01).The adverse reaction rates in intensive treatment group and conventional treatment group were 16.67% and 10.00%, respectively, the difference of which was not statistically significant(P>0.05).Conclusions:The application of atorvastatin in the treatment of the coronary heart disease patients treated with CABG before and after surgery can significantly regulate blood lipid and improve heart function, which does not increase adverse reactions, and is safe and effective.
Objective:To explore the effects of different doses of atorvastatin on the cardiac function and lipid in the patients with coronary heart disease after coronary artery bypass grafting(CABG).Methods:Sixty patients with coronary artery disease scheduled by CABG were randomly divided into the intensive treatment group(40 mg/d) and conventional treatment group(20 mg/d) according to the dose of atorvastatn before and after the surgery(30 cases each group).The blood lipid level and echocardiographic finding between two groups were compared before and after surgery, and the adverse reactions in two groups were recorded during treatment.Results:After treatment, the reduction of total cholesterol, triglyceride and low-density lipoprotein-cholesterol and increasing degree of high-density lipoprotein-cholesterol in intensive treatment group were better than those in conventional treatment group(P<0.05 to P<0.01).After treatment, the reduction of left ventricular end systolic volume index, left ventricular end-diastolic volume index and A peak and increasing degree of E peak, E/A and left ventricular ejection fraction in intensive treatment group were better than those in conventional treatment group(P<0.01).The adverse reaction rates in intensive treatment group and conventional treatment group were 16.67% and 10.00%, respectively, the difference of which was not statistically significant(P>0.05).Conclusions:The application of atorvastatin in the treatment of the coronary heart disease patients treated with CABG before and after surgery can significantly regulate blood lipid and improve heart function, which does not increase adverse reactions, and is safe and effective.
2015, 40(6): 749-751.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.016
Abstract:
Objective:To evaluate the clinical effects of the second electric resection of two kinds of endoscopic resection in T1G3 bladder cancer.Methods:Eighty-two T1G3 bladder cancer patients diagnosed by pathological results of the first transurethral resection of bladder tumor(TURBT) were randomly divided into group A(38 cases) and group B(48 cases).Within postoperative 4 weeks, the group A and group B were treated with the second TURBT and transurethral plasma kinetic resection of bladder tumor, respectively.The time of operation and postoperative bladder irrigation, obturator nerve reflex rate, muscle layer lack rate and second postoperative pathological staging between two groups were compared.Results:The differences of the time of operation and postoperative bladder irrigation, obturator nerve reflex rate and muscle layer lack rate between two groups were statistically significant(P<0.05 to P<0.01).The difference of the second postoperative pathological staging between two groups was not statistically significant(P>0.05).Conclusions:The TURBT is less bleeding, clear cutting layer and good clinical effects, which can short the time of operation and postoperative bladder irrigation, reduce the obturator nerve reflex and improve the accuracy of tumor pathological stage.
Objective:To evaluate the clinical effects of the second electric resection of two kinds of endoscopic resection in T1G3 bladder cancer.Methods:Eighty-two T1G3 bladder cancer patients diagnosed by pathological results of the first transurethral resection of bladder tumor(TURBT) were randomly divided into group A(38 cases) and group B(48 cases).Within postoperative 4 weeks, the group A and group B were treated with the second TURBT and transurethral plasma kinetic resection of bladder tumor, respectively.The time of operation and postoperative bladder irrigation, obturator nerve reflex rate, muscle layer lack rate and second postoperative pathological staging between two groups were compared.Results:The differences of the time of operation and postoperative bladder irrigation, obturator nerve reflex rate and muscle layer lack rate between two groups were statistically significant(P<0.05 to P<0.01).The difference of the second postoperative pathological staging between two groups was not statistically significant(P>0.05).Conclusions:The TURBT is less bleeding, clear cutting layer and good clinical effects, which can short the time of operation and postoperative bladder irrigation, reduce the obturator nerve reflex and improve the accuracy of tumor pathological stage.
2015, 40(6): 752-753,756.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.017
Abstract:
Objective:To investigate the expressions of interleukin-6(IL-6) in serum and cerebrospinal fluid(CSF) of patients with acute craniocerebral injury and its significance.Methods:Thirty-six patients with acute craniocerebral injury were divided into the moderate-severe injury group(GCS≤12, 15 cases) and mild injury group(GCS>12, 21 cases) according to the GCS, 19 patients without nerve system disease were used as the control group.The levels of IL-6 in CSF and serum in all cases were detected by ELISA.Results:The levels of IL-6 in CSF and serum in moderate-severe injury group were significantly higher than those in mild injury group and control group, respectively(P<0.01).The levels of IL-6 in CSF and serum in mild injury group were obviously higher than those in control group, respectively(P<0.01).The levels of IL-6 in CSF was higher than that in serum in mildinjury group, moderate-severe group and control group(P<0.05 to P<0.01).Conclusions:The levels of IL-6 in CSF and serum of patients with acute craniocerebral injury are associated with its injury level.The different expression of IL-6 between serum and CSF has an important role on investigating the injury mechanism of brain.
Objective:To investigate the expressions of interleukin-6(IL-6) in serum and cerebrospinal fluid(CSF) of patients with acute craniocerebral injury and its significance.Methods:Thirty-six patients with acute craniocerebral injury were divided into the moderate-severe injury group(GCS≤12, 15 cases) and mild injury group(GCS>12, 21 cases) according to the GCS, 19 patients without nerve system disease were used as the control group.The levels of IL-6 in CSF and serum in all cases were detected by ELISA.Results:The levels of IL-6 in CSF and serum in moderate-severe injury group were significantly higher than those in mild injury group and control group, respectively(P<0.01).The levels of IL-6 in CSF and serum in mild injury group were obviously higher than those in control group, respectively(P<0.01).The levels of IL-6 in CSF was higher than that in serum in mildinjury group, moderate-severe group and control group(P<0.05 to P<0.01).Conclusions:The levels of IL-6 in CSF and serum of patients with acute craniocerebral injury are associated with its injury level.The different expression of IL-6 between serum and CSF has an important role on investigating the injury mechanism of brain.
2015, 40(6): 754-756.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.018
Abstract:
Objective:To investigate the safety and effectiveness of the pemetrexed in the treatment of the initial or recurrent advanced non-small cell lung cancer(NSCLC).Methods:The 18 cases of the first-line treatment and 23 cases of the secondary-line treatment in 41 cases with advanced NSCLC identified by pathology or cytology were treated with 500 mg/m2 of pemetrexed at the first day combined with 25 mg/m2 of cisplatin at 2, 3 and 4 days or 5 AUC of carboplatin at the first day by intravenous drip, 3 weeks for a course.The safety and effectiveness of treatment were evaluated.Results:Partial response in 7 cases, stabilization in 4 cases, progress in 7 cases and no complete response cases in 18 cases with the first-line treatment were found, the effective rate and disease control rate were 38.89% and 61.11%, respectively, and the median progression-free survival time of which was 6.8 months.Partial response in 2 cases, stabilization in 9 cases, progress in 12 cases and no complete response cases in 23 cases with the second-line treatment were found, the effective rate and disease control rate were 8.70% and 47.83%, respectively, and the median progression-free survival time of which was 2.6 months.The major adverse reactions in two groups included fatigue, white blood cells decreasing, anemia and gastrointestinal tract reaction.Conclusions:The effects of pemetrexed combined with platinum in the first-line and second-line treatment of advanced NSCLC are good, high safety and good tolerance.
Objective:To investigate the safety and effectiveness of the pemetrexed in the treatment of the initial or recurrent advanced non-small cell lung cancer(NSCLC).Methods:The 18 cases of the first-line treatment and 23 cases of the secondary-line treatment in 41 cases with advanced NSCLC identified by pathology or cytology were treated with 500 mg/m2 of pemetrexed at the first day combined with 25 mg/m2 of cisplatin at 2, 3 and 4 days or 5 AUC of carboplatin at the first day by intravenous drip, 3 weeks for a course.The safety and effectiveness of treatment were evaluated.Results:Partial response in 7 cases, stabilization in 4 cases, progress in 7 cases and no complete response cases in 18 cases with the first-line treatment were found, the effective rate and disease control rate were 38.89% and 61.11%, respectively, and the median progression-free survival time of which was 6.8 months.Partial response in 2 cases, stabilization in 9 cases, progress in 12 cases and no complete response cases in 23 cases with the second-line treatment were found, the effective rate and disease control rate were 8.70% and 47.83%, respectively, and the median progression-free survival time of which was 2.6 months.The major adverse reactions in two groups included fatigue, white blood cells decreasing, anemia and gastrointestinal tract reaction.Conclusions:The effects of pemetrexed combined with platinum in the first-line and second-line treatment of advanced NSCLC are good, high safety and good tolerance.
2015, 40(6): 757-758,761.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.019
Abstract:
Objective:To explore the relationship between the level of serum uric acid(UA) and acute cerebral infarction(ACI) in young and middle-aged patients.Methods:Ninty-six young and middle-aged patients with ACI and 100 healthy people were divided into the ACI group and control group, respectively.The fasting serum glucose, UA, triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein in two groups were compared.Results:The level of serum UA in ACI group(382±110)μmol/L was significantly higher than that in control group(266±101)μmol/L(P<0.01).The abnormal rate of UA in ACI group(32.99%) was significantly higher than that in control group(12.00%)(P<0.01).After triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein were adjusted, logistic regression analysis demonstrated that the level of serum UA was positive correlation with the ACI(OR=1.006, 95%CI:1.003 to 1.011, P<0.05).Conclusions:The level of serum UA is one of risk factors of ACI in young and middle-aged patients.
Objective:To explore the relationship between the level of serum uric acid(UA) and acute cerebral infarction(ACI) in young and middle-aged patients.Methods:Ninty-six young and middle-aged patients with ACI and 100 healthy people were divided into the ACI group and control group, respectively.The fasting serum glucose, UA, triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein in two groups were compared.Results:The level of serum UA in ACI group(382±110)μmol/L was significantly higher than that in control group(266±101)μmol/L(P<0.01).The abnormal rate of UA in ACI group(32.99%) was significantly higher than that in control group(12.00%)(P<0.01).After triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein were adjusted, logistic regression analysis demonstrated that the level of serum UA was positive correlation with the ACI(OR=1.006, 95%CI:1.003 to 1.011, P<0.05).Conclusions:The level of serum UA is one of risk factors of ACI in young and middle-aged patients.
2015, 40(6): 759-761.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.020
Abstract:
Objective:To evaluate the accuracy and validity of predication scale of pneumonia after acute stroke.Methods:The scores of 312 patients with acute stroke during the admission to hospital were evaluated using the predication scale of pneumonia, and the number of patients infected with pneumonia were observed in the duration of hospital.The accuracy of the predication scale was analyzed using the receiver operating characteristic, the sensitivity, specificity, positive predictive value, negative predictive value, negative likely ratio and positive likely ratio of the predication scale were used to validate its validity.Results:The occurrence rate of pneumonia was 18.9%, which was significantly positive correlation with the score of scale(P<0.01).The receiver operating characteristic curve was established, the area under curve was 0.836(95%CI 0.779 to 0.894, P<0.01).When both sensitivity and specificity were more than 0.50 and taking 3 points was the best, the sensitivity, positive predictive value and positive likely ratio, and the specificity, negative predictive value and negative likely ratio were 69.5%, 52.7% and 3.663, and 81.0%, 89.7% and 0.377, respectively.Conclusions:The accuracy of the predication scale of pneumonia after acute stroke is 83.6%.The validity of scale in detecting of pneumonia after acute stroke has certain limitation, but in excluding pneumonia after acute stroke its value is high.The predication scale has certainly practical value in the predication of pneumonia after acute stroke.
Objective:To evaluate the accuracy and validity of predication scale of pneumonia after acute stroke.Methods:The scores of 312 patients with acute stroke during the admission to hospital were evaluated using the predication scale of pneumonia, and the number of patients infected with pneumonia were observed in the duration of hospital.The accuracy of the predication scale was analyzed using the receiver operating characteristic, the sensitivity, specificity, positive predictive value, negative predictive value, negative likely ratio and positive likely ratio of the predication scale were used to validate its validity.Results:The occurrence rate of pneumonia was 18.9%, which was significantly positive correlation with the score of scale(P<0.01).The receiver operating characteristic curve was established, the area under curve was 0.836(95%CI 0.779 to 0.894, P<0.01).When both sensitivity and specificity were more than 0.50 and taking 3 points was the best, the sensitivity, positive predictive value and positive likely ratio, and the specificity, negative predictive value and negative likely ratio were 69.5%, 52.7% and 3.663, and 81.0%, 89.7% and 0.377, respectively.Conclusions:The accuracy of the predication scale of pneumonia after acute stroke is 83.6%.The validity of scale in detecting of pneumonia after acute stroke has certain limitation, but in excluding pneumonia after acute stroke its value is high.The predication scale has certainly practical value in the predication of pneumonia after acute stroke.
2015, 40(6): 762-764,767.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.021
Abstract:
Objective:To summary the genotyping, clinical manifestations, diagnosis and clinical treatment of eosinophil gastroenteritis(EG).Methods:One EG child with recurrent gastrointestinal symptoms, excluding parasitic infections, blood system cancer and other diseases, was dignosed by examination, who was treated with anti-allergic drugs, leukotriene inhibitor and corticosteroid.The time of clinical symptoms remission and disappear, and laboratory index recovery were observed.Results:The recurrent vomiting, abdominal pain, diarrhea and other gastrointestinal symptoms, even dysphagia, intestinal obstruction and intestinal perforation, were the clinical features of EG.The laboratory test showed that eosinophilia granulocyte of peripheral blood increased.The rough mucosal congestion and edema, and point flake erythema or erosion were found by endoscopic examination.Fifteen to twenty eosinophils per high power field of the lesion were identified by pathology examination.The laboratory parameters returned to normal level, and clinical symptoms improved or disappeared after treatment.Conclusions:EG is a gastrointestinal allergic benign disease, the effect of which treated with corticosteroid is effective.
Objective:To summary the genotyping, clinical manifestations, diagnosis and clinical treatment of eosinophil gastroenteritis(EG).Methods:One EG child with recurrent gastrointestinal symptoms, excluding parasitic infections, blood system cancer and other diseases, was dignosed by examination, who was treated with anti-allergic drugs, leukotriene inhibitor and corticosteroid.The time of clinical symptoms remission and disappear, and laboratory index recovery were observed.Results:The recurrent vomiting, abdominal pain, diarrhea and other gastrointestinal symptoms, even dysphagia, intestinal obstruction and intestinal perforation, were the clinical features of EG.The laboratory test showed that eosinophilia granulocyte of peripheral blood increased.The rough mucosal congestion and edema, and point flake erythema or erosion were found by endoscopic examination.Fifteen to twenty eosinophils per high power field of the lesion were identified by pathology examination.The laboratory parameters returned to normal level, and clinical symptoms improved or disappeared after treatment.Conclusions:EG is a gastrointestinal allergic benign disease, the effect of which treated with corticosteroid is effective.
2015, 40(6): 765-767.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.022
Abstract:
Objective:To investigate the therapeutic efficacy of the total and proximal gastrectomy in the treatment of adenocarcinoma of the esophagogastric junction(AEG).Methods:Forty-three patients with advanced adenocarcinoma of the esophagogastric junction were randomly divided into the total gastrectomy group(TG group, 22 cases) and proximal gastrectomy group(PG group, 21 cases).The average operation time, intraoperative blood loss, hospitalization time, incidence of complications, residual stomach syndrome and postoperative 1 and 2-year survival rates between two groups were compared.Results:The differences of the operation time, intraoperative blood loss, hospitalization time, incidence of complications, residual stomach syndrome and 1-year survival rate between two groups were not statistically significant(P>0.05), the difference of the 2-year survival rate between two groups was statistically significant(P<0.05).Conclusions:The total gastrectomy for treating the patients with advanced adenocarcinoma of the esophagogastric junction can increase their postoperative survival time, decrease their incidence of complications and improve their living quality, which is an ideal operation method.
Objective:To investigate the therapeutic efficacy of the total and proximal gastrectomy in the treatment of adenocarcinoma of the esophagogastric junction(AEG).Methods:Forty-three patients with advanced adenocarcinoma of the esophagogastric junction were randomly divided into the total gastrectomy group(TG group, 22 cases) and proximal gastrectomy group(PG group, 21 cases).The average operation time, intraoperative blood loss, hospitalization time, incidence of complications, residual stomach syndrome and postoperative 1 and 2-year survival rates between two groups were compared.Results:The differences of the operation time, intraoperative blood loss, hospitalization time, incidence of complications, residual stomach syndrome and 1-year survival rate between two groups were not statistically significant(P>0.05), the difference of the 2-year survival rate between two groups was statistically significant(P<0.05).Conclusions:The total gastrectomy for treating the patients with advanced adenocarcinoma of the esophagogastric junction can increase their postoperative survival time, decrease their incidence of complications and improve their living quality, which is an ideal operation method.
The effects of Tai Chi and Fitness Walking on the static balance ability in women over the age of 70
2015, 40(6): 773-776,780.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.025
Abstract:
Objective:To investigate the effects of Tai Chi and Fitness Walking on the static balance ability of the elderly women, in order to provide scientific guidance.Methods:The balance abilities of 146 elderly women over the age of 70 from a city were investigated.The elderly women were divided into the 70 to 79 years old group and equal to and more than 80 years old group according to their ages.The exercise ways included the Tai Chi, Fitness Walking and irregular movement.The measure index included the envelope area, and the trace length of postural sway and X and Y direction.Results:The balance ability in 70 to 79 years old group was better than that in equal to and more than 80 years old group(P<0.05 to P<0.01).The balance ability began to decreased with the increase of age, which did not be affected by exercise.The decreasing range regularity from large to small was the irregular movement, Fitness Walking and Tai Chi in turn.The irregular movement, Fitness Walking and Tai Chi could improve the balance ability in the same age elderly women(P<0.01), the effect of Tai Chi was better than that of Fitness Walking(P<0.05 to P<0.01).Conclusions:The static balance ability begin to decrease with the increase of age.The physical exercise can slow down the trend, and the exercise effect of Tai Chi is better.
Objective:To investigate the effects of Tai Chi and Fitness Walking on the static balance ability of the elderly women, in order to provide scientific guidance.Methods:The balance abilities of 146 elderly women over the age of 70 from a city were investigated.The elderly women were divided into the 70 to 79 years old group and equal to and more than 80 years old group according to their ages.The exercise ways included the Tai Chi, Fitness Walking and irregular movement.The measure index included the envelope area, and the trace length of postural sway and X and Y direction.Results:The balance ability in 70 to 79 years old group was better than that in equal to and more than 80 years old group(P<0.05 to P<0.01).The balance ability began to decreased with the increase of age, which did not be affected by exercise.The decreasing range regularity from large to small was the irregular movement, Fitness Walking and Tai Chi in turn.The irregular movement, Fitness Walking and Tai Chi could improve the balance ability in the same age elderly women(P<0.01), the effect of Tai Chi was better than that of Fitness Walking(P<0.05 to P<0.01).Conclusions:The static balance ability begin to decrease with the increase of age.The physical exercise can slow down the trend, and the exercise effect of Tai Chi is better.
2015, 40(6): 777-780.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.026
Abstract:
Objective:To explore the effects of the dynamic change of body mass index(BMI) and waist circumference(WC) during 1-year follow-up on the blood pressure of elder hypertensive patients.Methods:The data of 60 to 75 years old 220 patients with hypertension was collected using questionnaire and body measurement, the same data were collect after 1 year again.The two times of blood pressure value were compared.The patients were divided into the blood pressure increasing group and blood pressure decreasing group according to the blood pressure level.The BMI and WC between two groups were compared.Results:Among the male patients, the rates of smoking and drinking in blood pressure increasing group were significantly higher than those in blood pressure decreasing group(P<0.01), but the exercise in blood pressure increasing group was less(P<0.01).Among the female patients, the differences of the rates of smoking and drinking between two groups were not statistically significant(P>0.05), but the exercise in blood pressure increasing group was less than that in blood pressure increasing group(P<0.01).Compared with the first value of BMI and WC in the blood pressure increasing group, the second value increased significantly(P<0.01).Compared with the first value of BMI and WC in the blood pressure decreasing group, the second value decreased significantly(P<0.01).The differences of systolic and diastolic blood pressure, BMI and WC between times measurement were positive correlation, respectively(P<0.01).Conclusions:The blood pressure increasing in elder hypertensive patients is related to the smoking, drinking and less exercise.The dynamic changes of MBI and WC are postively associated with hypertension.
Objective:To explore the effects of the dynamic change of body mass index(BMI) and waist circumference(WC) during 1-year follow-up on the blood pressure of elder hypertensive patients.Methods:The data of 60 to 75 years old 220 patients with hypertension was collected using questionnaire and body measurement, the same data were collect after 1 year again.The two times of blood pressure value were compared.The patients were divided into the blood pressure increasing group and blood pressure decreasing group according to the blood pressure level.The BMI and WC between two groups were compared.Results:Among the male patients, the rates of smoking and drinking in blood pressure increasing group were significantly higher than those in blood pressure decreasing group(P<0.01), but the exercise in blood pressure increasing group was less(P<0.01).Among the female patients, the differences of the rates of smoking and drinking between two groups were not statistically significant(P>0.05), but the exercise in blood pressure increasing group was less than that in blood pressure increasing group(P<0.01).Compared with the first value of BMI and WC in the blood pressure increasing group, the second value increased significantly(P<0.01).Compared with the first value of BMI and WC in the blood pressure decreasing group, the second value decreased significantly(P<0.01).The differences of systolic and diastolic blood pressure, BMI and WC between times measurement were positive correlation, respectively(P<0.01).Conclusions:The blood pressure increasing in elder hypertensive patients is related to the smoking, drinking and less exercise.The dynamic changes of MBI and WC are postively associated with hypertension.
2015, 40(6): 781-784.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.027
Abstract:
Objective:To investigate the clinical value of the uterine artery blood flow detected by Doppler ultrasound in predicting the high-risk pregnancy outcome.Methods:One hundred and twenty high-risk pregnancy patients and 100 normal pregnant women were divided into the observation group and control group, respectively.The peak systolic velocity/end diastolic velocity(S/D), uterine artery score, pulsatility index(PI) and resistance index(RI) between two groups were analyzed, and the ROC curve were established.The different S/D values of maternity, and the weight, growth restriction and proportion of suffocation of newborn in observation group were recorded.Results:The S/D value, PI and RI in observation group(2.93±1.04, 0.73±0.19 and 1.39±0.82) were significantly higher than those in control group(2.21±0.29, 0.54±0.12 and 1.08±0.37), respectively(P<0.01).In observation group, the newborn weight in puerperal with S/D value≥2.8(3 192±204)g was significantly lower than that in puerperal with S/D value<2.8(3 327±284 )g(P<0.01).In observation group, the growth restriction and asphyxia rates of newborn in puerperal with S/D value≥2.8(68.12% and 42.03%) were significantly higher than those in puerperal with S/D value<2.8(19.61% and 13.73%), respectively(P<0.01).The premature, SGA, PI, RI, SD and area under the ROC curve were gradually decreased in observation group.Conclusions:The high-frequency ultrasonic doppler of uterine artery can detect the hemodynamic parameters in high-risk pregnancy.The patient's condition can be determined by S/D value, which has certain clinic value.
Objective:To investigate the clinical value of the uterine artery blood flow detected by Doppler ultrasound in predicting the high-risk pregnancy outcome.Methods:One hundred and twenty high-risk pregnancy patients and 100 normal pregnant women were divided into the observation group and control group, respectively.The peak systolic velocity/end diastolic velocity(S/D), uterine artery score, pulsatility index(PI) and resistance index(RI) between two groups were analyzed, and the ROC curve were established.The different S/D values of maternity, and the weight, growth restriction and proportion of suffocation of newborn in observation group were recorded.Results:The S/D value, PI and RI in observation group(2.93±1.04, 0.73±0.19 and 1.39±0.82) were significantly higher than those in control group(2.21±0.29, 0.54±0.12 and 1.08±0.37), respectively(P<0.01).In observation group, the newborn weight in puerperal with S/D value≥2.8(3 192±204)g was significantly lower than that in puerperal with S/D value<2.8(3 327±284 )g(P<0.01).In observation group, the growth restriction and asphyxia rates of newborn in puerperal with S/D value≥2.8(68.12% and 42.03%) were significantly higher than those in puerperal with S/D value<2.8(19.61% and 13.73%), respectively(P<0.01).The premature, SGA, PI, RI, SD and area under the ROC curve were gradually decreased in observation group.Conclusions:The high-frequency ultrasonic doppler of uterine artery can detect the hemodynamic parameters in high-risk pregnancy.The patient's condition can be determined by S/D value, which has certain clinic value.
2015, 40(6): 784-786.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.028
Abstract:
Objective:To evaluate the effects of ultrasound elastography combined with color doppler flow imaging in the diagnosis of breast cancer.Methods:The breast cancer(138 breast nodules) in 98 patients were detected by ultrasound elastography, color doppler flow imaging and ultrasound elastography combined with color doppler flow imaging.The diagnostic results of three methods were compared according to the pathology imaging.Results:The pathology results showed that 96 nodules in 64 patients were benign, 42 nodules in 42 patients were malignant.The differences of benign and malignant breast nodules of patients between pathology results and CDFI, UE and CDFI+UE test results were not significant(P>0.05).The diagnostic sensitivities of ultrasound elastography, color doppler flow imaging and ultrasound elastography combined with color doppler flow imaging were 83.33%, 88.10% and 97.62%, respectively.The specificities and diagnostic accuracy of ultrasound elastography, color doppler flow imaging and ultrasound elastography combined with color doppler flow imaging were 92.71% & 91.30%, 93.83% & 92.03% and 96.88% & 97.10%.Conclusions:The diagnostic sensitivity, specificity and accuracy of ultrasound elastography combined with color doppler flow imaging in the diagnosis of breast cancer are high, which is worthy of clinical application.
Objective:To evaluate the effects of ultrasound elastography combined with color doppler flow imaging in the diagnosis of breast cancer.Methods:The breast cancer(138 breast nodules) in 98 patients were detected by ultrasound elastography, color doppler flow imaging and ultrasound elastography combined with color doppler flow imaging.The diagnostic results of three methods were compared according to the pathology imaging.Results:The pathology results showed that 96 nodules in 64 patients were benign, 42 nodules in 42 patients were malignant.The differences of benign and malignant breast nodules of patients between pathology results and CDFI, UE and CDFI+UE test results were not significant(P>0.05).The diagnostic sensitivities of ultrasound elastography, color doppler flow imaging and ultrasound elastography combined with color doppler flow imaging were 83.33%, 88.10% and 97.62%, respectively.The specificities and diagnostic accuracy of ultrasound elastography, color doppler flow imaging and ultrasound elastography combined with color doppler flow imaging were 92.71% & 91.30%, 93.83% & 92.03% and 96.88% & 97.10%.Conclusions:The diagnostic sensitivity, specificity and accuracy of ultrasound elastography combined with color doppler flow imaging in the diagnosis of breast cancer are high, which is worthy of clinical application.
2015, 40(6): 792-794.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.031
Abstract:
Objective:To investigate the value of the combined detection of fasting plasma glucose(FPG) and glycated hemoglobin A1c(HbA1c) in physical examination.Methods:The levels of FPG and HbA1c in 263 healthy people were detected, and their correlations were analyzed.Results:Among the HbA1c level of 263 healthy people, 139 cases was less than 5.5%, 88 cases was between 5.5% and 6.5% and 36 cases was more than 6.5%.FPG level of the physical examination people with HbA1c level higher than 6.5% was significantly higher than that of the HbA1c level less than 6.5% and between 5.5% and 6.5%(P<0.01).Pearson product moment correlation analysis showed that the level of HbA1c was positive correlation with FPG(P<0.01).Conclusions:The combined detection of HbA1c and FPG in healthy physical examination has important value in screening diabetes, which is worthy to be popularized.
Objective:To investigate the value of the combined detection of fasting plasma glucose(FPG) and glycated hemoglobin A1c(HbA1c) in physical examination.Methods:The levels of FPG and HbA1c in 263 healthy people were detected, and their correlations were analyzed.Results:Among the HbA1c level of 263 healthy people, 139 cases was less than 5.5%, 88 cases was between 5.5% and 6.5% and 36 cases was more than 6.5%.FPG level of the physical examination people with HbA1c level higher than 6.5% was significantly higher than that of the HbA1c level less than 6.5% and between 5.5% and 6.5%(P<0.01).Pearson product moment correlation analysis showed that the level of HbA1c was positive correlation with FPG(P<0.01).Conclusions:The combined detection of HbA1c and FPG in healthy physical examination has important value in screening diabetes, which is worthy to be popularized.
2015, 40(6): 794-797.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.032
Abstract:
Objective:To evaluate the main performance index of UF-1000i urinary sediment analyzer.Methods:The precision, contaminative rate, linear range and uncertainty of the UF-1000i were analyzed by detecting fresh urine and constant quality control product.Results:The within-run precisions(CV) of UF-1000i in detecting WBC, RBC, BACT, EC, CAST were 4.0%-7.6%, 4.4%-6.6%, 5.9%-8.9%, 5.7%-10.7% and 7.0%-13.5%, respectively.The inter-day precisions of UF-1000i in detecting WBC, RBC, BACT, EC, CAST were 2.1%-6.3%, 4.8%-5.3%, 7.2%-9.7%, 8.0%-15.0%, 9.5%-14.1%, respectively.The contaminative rates of UF-1000i in detecting WBC, RBC, BACT, EC, CAST in fresh urinary were 0.120%, 0.039%, 0.084%, 0.700% and 1.640%, respectively.The levels of WBC, RBC, BACT, EC and CAST in urinary were 1.4-5 097/μl, 1.2-4 885/μl, 8-16 540/μl, 2.9-204/μl and 1.2-19.4/μl, respectively, which was good linear correlation.The relative deviations of UF-1000i in detecting WBC, RBC, BACT, EC and CAST were 2.4%-9.0%, 0.9%-9.8%, -18.2%--18.0%, -13.5%--5.1% and -3.7%--6.8%, respectively.Conclusions:The main performance index of UF-1000i is qualified, which can be used to analyze the formed elements of urinary.
Objective:To evaluate the main performance index of UF-1000i urinary sediment analyzer.Methods:The precision, contaminative rate, linear range and uncertainty of the UF-1000i were analyzed by detecting fresh urine and constant quality control product.Results:The within-run precisions(CV) of UF-1000i in detecting WBC, RBC, BACT, EC, CAST were 4.0%-7.6%, 4.4%-6.6%, 5.9%-8.9%, 5.7%-10.7% and 7.0%-13.5%, respectively.The inter-day precisions of UF-1000i in detecting WBC, RBC, BACT, EC, CAST were 2.1%-6.3%, 4.8%-5.3%, 7.2%-9.7%, 8.0%-15.0%, 9.5%-14.1%, respectively.The contaminative rates of UF-1000i in detecting WBC, RBC, BACT, EC, CAST in fresh urinary were 0.120%, 0.039%, 0.084%, 0.700% and 1.640%, respectively.The levels of WBC, RBC, BACT, EC and CAST in urinary were 1.4-5 097/μl, 1.2-4 885/μl, 8-16 540/μl, 2.9-204/μl and 1.2-19.4/μl, respectively, which was good linear correlation.The relative deviations of UF-1000i in detecting WBC, RBC, BACT, EC and CAST were 2.4%-9.0%, 0.9%-9.8%, -18.2%--18.0%, -13.5%--5.1% and -3.7%--6.8%, respectively.Conclusions:The main performance index of UF-1000i is qualified, which can be used to analyze the formed elements of urinary.
2015, 40(6): 798-800.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.033
Abstract:
Objective:To explore the changes of lymphocyte subsets in children with idiopathic thrombocytopenic purpura(ITP).Methods:The changes of lymphocyte subsets in 85 patients with ITP and 33 heathy people were detected by flow cytometry.Results:The percentages of CD3+ and CD4+ and the ratio of CD4/CD8 in ITP group were lower than those in control group(P<0.01), and the difference of CD8+ lymphocyte between two groups was not statistically significant(P>0.05).Compared with the control group, the number of CD19+ and CD16+CD56+ lymphocytes in ITP group increased and decreased, respectively, the differences of whose between two groups were statistically significant(P<0.01).Conclusions:The disorder of lymphocyte subsets is one of the immune mechanism of ITP occurrence in children.Correcting disorder will be conducive to the treatment.
Objective:To explore the changes of lymphocyte subsets in children with idiopathic thrombocytopenic purpura(ITP).Methods:The changes of lymphocyte subsets in 85 patients with ITP and 33 heathy people were detected by flow cytometry.Results:The percentages of CD3+ and CD4+ and the ratio of CD4/CD8 in ITP group were lower than those in control group(P<0.01), and the difference of CD8+ lymphocyte between two groups was not statistically significant(P>0.05).Compared with the control group, the number of CD19+ and CD16+CD56+ lymphocytes in ITP group increased and decreased, respectively, the differences of whose between two groups were statistically significant(P<0.01).Conclusions:The disorder of lymphocyte subsets is one of the immune mechanism of ITP occurrence in children.Correcting disorder will be conducive to the treatment.
2015, 40(6): 800-801,804.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.034
Abstract:
Objective:To explore the influence of blood exchange transfusion on blood parameters in neonates with hyperbilirubinemia.Methods:Thirty-two hyperbilirubinemia neonates were accepted to do exchange transfusion by peripheral artery and vein synchronously, the serum biochemical parameters, blood routine indexes, and arterial blood gas analysis were detected before and after exchange transfusion.Results:After exchange transfusion, the serum total bilirubin and indirect bilirubin levels were significantly lower than before(P<0.01);white blood cells and platelets levels were decreased(P<0.01);red blood cells and hemoglobin levels had no statistically significant differences(P>0.05);blood sugar level was elevated significantly(P<0.01);blood potassium, sodium, chloride, calcium concentrations, pH and base excess change had no statistical differences(P>0.05).Conclusions:Serum bilirubin level was decreased significantly after exchange transfusion in hyperbilirubinemia neonates, but blood indexes such as white blood cells, platelets, blood sugar also had changed, so it is need to detect biochemical parameters and blood routine indexes in order to prevent the happening of electrolyte disorder and hemorrhage, infection.
Objective:To explore the influence of blood exchange transfusion on blood parameters in neonates with hyperbilirubinemia.Methods:Thirty-two hyperbilirubinemia neonates were accepted to do exchange transfusion by peripheral artery and vein synchronously, the serum biochemical parameters, blood routine indexes, and arterial blood gas analysis were detected before and after exchange transfusion.Results:After exchange transfusion, the serum total bilirubin and indirect bilirubin levels were significantly lower than before(P<0.01);white blood cells and platelets levels were decreased(P<0.01);red blood cells and hemoglobin levels had no statistically significant differences(P>0.05);blood sugar level was elevated significantly(P<0.01);blood potassium, sodium, chloride, calcium concentrations, pH and base excess change had no statistical differences(P>0.05).Conclusions:Serum bilirubin level was decreased significantly after exchange transfusion in hyperbilirubinemia neonates, but blood indexes such as white blood cells, platelets, blood sugar also had changed, so it is need to detect biochemical parameters and blood routine indexes in order to prevent the happening of electrolyte disorder and hemorrhage, infection.
2015, 40(6): 802-804.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.035
Abstract:
Objective:To explore the clinical value of the levels of carcinoembryonic antigen(CEA) and carbohydrate antigen 125(CA125) in the diagnosis of lung cancer.Methods:Fifty patients with lung cancer and 50 patients with benign lesion from June 2012 to May 2014 were divided into the lung cancer group and benign lesion group, respectively.Fifty healthy people were set as healthy control group.The serum levels of CEA and CA125 in 3 groups were detected using electrochemiluminescence, which was analyzed.Results:The levels of CEA and CA125 in lung cancer group were significantly higher than those in the benign lesion group and healthy control group(P<0.01), the differences of the levels of CEA and CA125 between the benign lesion group and healthy control group were not statistically significant(P>0.05).The differences of the positive diagnosis rate between the combined detection of CEA and CA125 and the single CEA or CA125 detection were not statistical significance(P>0.05).Conclusions:The levels of CEA and CA125 in patients with lung cancer increase significantly.The detection of CEA and CA125 can provide the basis for early diagnosis and treatment of lung cancer.
Objective:To explore the clinical value of the levels of carcinoembryonic antigen(CEA) and carbohydrate antigen 125(CA125) in the diagnosis of lung cancer.Methods:Fifty patients with lung cancer and 50 patients with benign lesion from June 2012 to May 2014 were divided into the lung cancer group and benign lesion group, respectively.Fifty healthy people were set as healthy control group.The serum levels of CEA and CA125 in 3 groups were detected using electrochemiluminescence, which was analyzed.Results:The levels of CEA and CA125 in lung cancer group were significantly higher than those in the benign lesion group and healthy control group(P<0.01), the differences of the levels of CEA and CA125 between the benign lesion group and healthy control group were not statistically significant(P>0.05).The differences of the positive diagnosis rate between the combined detection of CEA and CA125 and the single CEA or CA125 detection were not statistical significance(P>0.05).Conclusions:The levels of CEA and CA125 in patients with lung cancer increase significantly.The detection of CEA and CA125 can provide the basis for early diagnosis and treatment of lung cancer.
2015, 40(6): 807-811.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.037
Abstract:
Objective:To investigate the status of the voluntary motivation and behavior, and its relationship in undergraduate nursing students.Methods:Seven hundred and ninety-two freshmen and junior undergraduate nursing students were investigated using the "voluntary motivation scale" and "voluntary behavior questionnaire" by the method of cluster sampling.Results:Five hundred and sixty-two(71%) students had participated in all kinds of volunteer service activities, 230 people(29%) had never participated in volunteer activities.Six dimensions scores of volunteer motivation scale from high to low in turn were the value expression(5.227), understanding knowledge(5.193), self enhancement(4.979), occupation career(4.766), self protection(4.247) and social communication(4.059).The scores of the value expression and understanding knowledge in nursing students from rural were higher than those in the students from city(P<0.01), the scores of the social communciation and occupation career in nursing students from rural were lower than the students from city(P<0.01).The scores of the value expression, understanding knowledge, self enhancement and volunteer motivation in the non-only children were higher than those in one child(P<0.05 to P<0.01).The scores of value expression and self enhancement in junior students were higher than those in sophomore and freshmen(P<0.05).The questionnaire score of voluntary behavior in freshman nursing students was the highest.The scores of the voluntary motivation, expression value, understanding knowledge and self enhancement in the junior nursing students were the highest.Correlation analysis showed that there were significantly positive correlation among the variables, the correlation coefficient of which was between 0.243 to 0.848(P<0.01).The multiple stepwise regression analysis showed that the social communication, self enhancement and voluntary motivation could predict the voluntary behavior.Conclusions:Voluntary motivation of nursing students has the pluralism tendency.Volunteer motivation has certain predictive effect on the voluntary behavior.The Communist Youth League in Colleges and Universities should focus on the development of voluntary service organizations, stimulate students to participate in voluntary service motivation, promote students to participate in various volunteer activities and cultivate the volunteer spirit of students.
Objective:To investigate the status of the voluntary motivation and behavior, and its relationship in undergraduate nursing students.Methods:Seven hundred and ninety-two freshmen and junior undergraduate nursing students were investigated using the "voluntary motivation scale" and "voluntary behavior questionnaire" by the method of cluster sampling.Results:Five hundred and sixty-two(71%) students had participated in all kinds of volunteer service activities, 230 people(29%) had never participated in volunteer activities.Six dimensions scores of volunteer motivation scale from high to low in turn were the value expression(5.227), understanding knowledge(5.193), self enhancement(4.979), occupation career(4.766), self protection(4.247) and social communication(4.059).The scores of the value expression and understanding knowledge in nursing students from rural were higher than those in the students from city(P<0.01), the scores of the social communciation and occupation career in nursing students from rural were lower than the students from city(P<0.01).The scores of the value expression, understanding knowledge, self enhancement and volunteer motivation in the non-only children were higher than those in one child(P<0.05 to P<0.01).The scores of value expression and self enhancement in junior students were higher than those in sophomore and freshmen(P<0.05).The questionnaire score of voluntary behavior in freshman nursing students was the highest.The scores of the voluntary motivation, expression value, understanding knowledge and self enhancement in the junior nursing students were the highest.Correlation analysis showed that there were significantly positive correlation among the variables, the correlation coefficient of which was between 0.243 to 0.848(P<0.01).The multiple stepwise regression analysis showed that the social communication, self enhancement and voluntary motivation could predict the voluntary behavior.Conclusions:Voluntary motivation of nursing students has the pluralism tendency.Volunteer motivation has certain predictive effect on the voluntary behavior.The Communist Youth League in Colleges and Universities should focus on the development of voluntary service organizations, stimulate students to participate in voluntary service motivation, promote students to participate in various volunteer activities and cultivate the volunteer spirit of students.
2015, 40(6): 812-813.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.038
Abstract:
Objective:To investigate the present status of well-being in the elderly in a city and the influencing factors.Methods:The elderly people in 4 communities in Yuhui District, Bengbu were randomly selected by optional sampling as study objects.All the subjects were surveyed by questionnaires by the Ministry of Health for the special group and ordinary gemology data.Results:Twenty-nine point five percent of them felt very happy, 45.1% happy, 22.7% sometimes happy and sometimes not, 1.5% happy occasionally and 1.1% unhappy.The happiness of the elderly was positively correlated with their appetite, sleeping quality, personal economic status and relation with the family, friends and neighbors(P<0.05 to P<0.01), whereas it had no correlation with the education background(P>0.05).Conclusions:The elderly in the city have strong sense of happiness, which is mainly influenced by their economic condition, appetite, sleeping quality and social relations.The well-being of the elderly could be increased by means of mobilizing every social field such as the government to enhance the social support, improve the cultural atmosphere and medical care of the community and execute psychological interventions.
Objective:To investigate the present status of well-being in the elderly in a city and the influencing factors.Methods:The elderly people in 4 communities in Yuhui District, Bengbu were randomly selected by optional sampling as study objects.All the subjects were surveyed by questionnaires by the Ministry of Health for the special group and ordinary gemology data.Results:Twenty-nine point five percent of them felt very happy, 45.1% happy, 22.7% sometimes happy and sometimes not, 1.5% happy occasionally and 1.1% unhappy.The happiness of the elderly was positively correlated with their appetite, sleeping quality, personal economic status and relation with the family, friends and neighbors(P<0.05 to P<0.01), whereas it had no correlation with the education background(P>0.05).Conclusions:The elderly in the city have strong sense of happiness, which is mainly influenced by their economic condition, appetite, sleeping quality and social relations.The well-being of the elderly could be increased by means of mobilizing every social field such as the government to enhance the social support, improve the cultural atmosphere and medical care of the community and execute psychological interventions.
2015, 40(6): 814-816.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.039
Abstract:
Objective:To investigate the English for general academic purpose(EGAP) needs of medical graduate students in order to provide a reference for EGAP courses.Methods:The EGAP needs of 113 medical graduate students were investigated using questionnaire, and 5 representative mentors were interviewed by semi-structured from a medical college.Results:Ninety-eight percent of graduate students required EGAP courses, in which reading was the most needed.They wanted to learn the characteristics of EGAP, academic writing and translating.Improving the writing ability was the primary goal of learning, secondly, reading and translation ability.Most graduate students thought that the EGAP courses should be taught by a high level of English teacher.Conclusions:EGAP can help graduate students to transition from college English study to academic writing.Offering EGAP courses for medical graduate students is strongly necessary.
Objective:To investigate the English for general academic purpose(EGAP) needs of medical graduate students in order to provide a reference for EGAP courses.Methods:The EGAP needs of 113 medical graduate students were investigated using questionnaire, and 5 representative mentors were interviewed by semi-structured from a medical college.Results:Ninety-eight percent of graduate students required EGAP courses, in which reading was the most needed.They wanted to learn the characteristics of EGAP, academic writing and translating.Improving the writing ability was the primary goal of learning, secondly, reading and translation ability.Most graduate students thought that the EGAP courses should be taught by a high level of English teacher.Conclusions:EGAP can help graduate students to transition from college English study to academic writing.Offering EGAP courses for medical graduate students is strongly necessary.
2015, 40(6): 817-821.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.040
Abstract:
Objective:To investigate the fund papers published on Journal of Bengbu Medical College from 2004 to 2014.Methods:The number of papers and fund projects, fund distribution and level, age, the professional title, work unit of the first author, and the distribution of the fund papers in different columns in 102 journals were statistically analyzed from 2004 to 2014.Results:Among the 5 278 papers publishing on Journal of Bengbu Medical College from 2004 to 2014, 862 papers were the fund papers, which accounted for 16.33% of the total, and showed the increasing trend year by year(χ2=29.78, P<0.01).The 862 papers were funded by 1 146 projects, which increased gradually year by year(χ2=89.30, P<0.01).The 86.31% of the projects was from Anhui Province, the most of which was provincial level project(35.27%).The first authors of these papers were mainly the young and middle-aged, medium-grade professional title and from universities and colleges.The fund papers publishing in the first 5 columns were the medical education, basic medical science, psychological medicine, review, technology and methods.Conclusions:The annual number of the papers and ratio of fund papers are relatively stable.Preferential publishing, no charge and year-end reward can attract the outstanding fund paper, improve the quality and promote development of the journal.
Objective:To investigate the fund papers published on Journal of Bengbu Medical College from 2004 to 2014.Methods:The number of papers and fund projects, fund distribution and level, age, the professional title, work unit of the first author, and the distribution of the fund papers in different columns in 102 journals were statistically analyzed from 2004 to 2014.Results:Among the 5 278 papers publishing on Journal of Bengbu Medical College from 2004 to 2014, 862 papers were the fund papers, which accounted for 16.33% of the total, and showed the increasing trend year by year(χ2=29.78, P<0.01).The 862 papers were funded by 1 146 projects, which increased gradually year by year(χ2=89.30, P<0.01).The 86.31% of the projects was from Anhui Province, the most of which was provincial level project(35.27%).The first authors of these papers were mainly the young and middle-aged, medium-grade professional title and from universities and colleges.The fund papers publishing in the first 5 columns were the medical education, basic medical science, psychological medicine, review, technology and methods.Conclusions:The annual number of the papers and ratio of fund papers are relatively stable.Preferential publishing, no charge and year-end reward can attract the outstanding fund paper, improve the quality and promote development of the journal.
2015, 40(6): 821-823.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.041
Abstract:
Objective:To explore the normalization nursing method of diabetics with intensive treatment of real-time dynamic insulin pump system.Methods:Forty diabetic patients were treated with interstitial fluid glucose monitoring and continuous subcutaneous insulin infusion by real-time dynamic insulin pump system, and psychological care, skin care, diet and exercise guidance.The adverse reactions and insulin pump alarm device were closely observed.Results:The levels of fasting plasma glucose on admission and 2-hour postprandial blood glucose of 40 patients after 6 days of treatment with real-time dynamic insulin pump system were significantly lower than those before treatment(P<0.01).The patients improved and discharged after 6 days of treatment.Conclusions:The normalization nursing method of diabetics with intensive treatment of real-time dynamic insulin pump system is safe and good hypoglycemic effect.
Objective:To explore the normalization nursing method of diabetics with intensive treatment of real-time dynamic insulin pump system.Methods:Forty diabetic patients were treated with interstitial fluid glucose monitoring and continuous subcutaneous insulin infusion by real-time dynamic insulin pump system, and psychological care, skin care, diet and exercise guidance.The adverse reactions and insulin pump alarm device were closely observed.Results:The levels of fasting plasma glucose on admission and 2-hour postprandial blood glucose of 40 patients after 6 days of treatment with real-time dynamic insulin pump system were significantly lower than those before treatment(P<0.01).The patients improved and discharged after 6 days of treatment.Conclusions:The normalization nursing method of diabetics with intensive treatment of real-time dynamic insulin pump system is safe and good hypoglycemic effect.
2015, 40(6): 824-827.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.042
Abstract:
Objective:To screen the preoperative nutritional risk patients with esophageal carcinoma using Nutritional Risk Screening(NRS) table-2002, comprehensively analyze the nutrition status of the patients and its relative influence factors by NRS table-2002 combined with laboratory detection of nutritional indexes so as to provide evidence for effective nutrition support in clinic.Methods:The preoperative nutritional risks of 62 patients with esophageal carcinoma were investigated using NRS table-2002.The RBP, ALB, Hb and RBC were detected and analyzed.Results:The malnutritional risk in 38 patients(61.29%) were found, the incidence of malnutritional risk in the patients more than 60 years old and patients with dysphagia were 79.49% and 68.63%, respectively.Logistic regression analysis showed that the age, body mass index, dysphagia or not were the related factors of preoperative nutritional risk(P<0.01).The RBP, PAB, ALB and Hb in the nutritional risk patients were lower than those in the non-nutritional risk patients(P<0.01).The difference of erythrocytes between the nutritional risk and non-nutritional risk patients was not statistically significant(P>0.05).Conclusions:The malnutrition risk in the preoperative patients with esophageal carcinoma is high.Medical staff should pay much attention to the dysphasia, equal to or more than 60 years old, physical deterioration and early change of RBP and PAB patients.The timely and effective nutritional support should be provided for the patients.
Objective:To screen the preoperative nutritional risk patients with esophageal carcinoma using Nutritional Risk Screening(NRS) table-2002, comprehensively analyze the nutrition status of the patients and its relative influence factors by NRS table-2002 combined with laboratory detection of nutritional indexes so as to provide evidence for effective nutrition support in clinic.Methods:The preoperative nutritional risks of 62 patients with esophageal carcinoma were investigated using NRS table-2002.The RBP, ALB, Hb and RBC were detected and analyzed.Results:The malnutritional risk in 38 patients(61.29%) were found, the incidence of malnutritional risk in the patients more than 60 years old and patients with dysphagia were 79.49% and 68.63%, respectively.Logistic regression analysis showed that the age, body mass index, dysphagia or not were the related factors of preoperative nutritional risk(P<0.01).The RBP, PAB, ALB and Hb in the nutritional risk patients were lower than those in the non-nutritional risk patients(P<0.01).The difference of erythrocytes between the nutritional risk and non-nutritional risk patients was not statistically significant(P>0.05).Conclusions:The malnutrition risk in the preoperative patients with esophageal carcinoma is high.Medical staff should pay much attention to the dysphasia, equal to or more than 60 years old, physical deterioration and early change of RBP and PAB patients.The timely and effective nutritional support should be provided for the patients.
2015, 40(6): 827-829.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.043
Abstract:
Objective:To investigate the impact of deep multi-dimensional nursing intervention on the life quality of patients with acute cerebral infarction merger and depression.Methods:Twenty four subjects in the observation group and 24 subjects in the control group were assessed by the activities of daily living(ADL) and Hamilton Depression(HAMD)Rating Scale before and after treatment;The clinical effects and assessment scores were compared between the two groups.Results:The scores of the ADL and the HAMD had no statistical differences between the two groups before intervention(P>0.05);after intervention, the scores of the ADL increased and the scores of the HAMD decreased in the two groups(P<0.01).The observation group displayed a higher degree of ADL and lower degree of HAMD than the control group(P<0.01 and P<0.05).Conclusions:Deep multi-dimensional nursing intervention has clinical effects on patients with acute cerebral infarction merger combined with depression.
Objective:To investigate the impact of deep multi-dimensional nursing intervention on the life quality of patients with acute cerebral infarction merger and depression.Methods:Twenty four subjects in the observation group and 24 subjects in the control group were assessed by the activities of daily living(ADL) and Hamilton Depression(HAMD)Rating Scale before and after treatment;The clinical effects and assessment scores were compared between the two groups.Results:The scores of the ADL and the HAMD had no statistical differences between the two groups before intervention(P>0.05);after intervention, the scores of the ADL increased and the scores of the HAMD decreased in the two groups(P<0.01).The observation group displayed a higher degree of ADL and lower degree of HAMD than the control group(P<0.01 and P<0.05).Conclusions:Deep multi-dimensional nursing intervention has clinical effects on patients with acute cerebral infarction merger combined with depression.
2015, 40(6): 830-832.
doi: 10.13898/j.cnki.issn.1000-2200.2015.06.044
Abstract:
Objective:To explore the effects of different nursing modes on the health knowledge and indwelling time and quality of life in patients with hemodialysis catheter.Methods:Eighty-two hemodialysis patients were randomly divided into the control group(n=41)and observation group(n=41).The control group were nursed with routine care, and the observation group were treated with diversified health education based on routine care.The health knowledge awareness, indwelling time, hospital stay, satisfaction and quality of life between two groups were compared and analyzed.Results:The awareness rates of diet, self-testing disease, complication management, medication and exercise in observation group were significantly higher than those in control group(P<0.01).The indwelling time, average length of stay and satisfaction scores in observation group were better than those in control group(P<0.01).After treatment, the physiological function, bodily pain, general health, physical function, social function, emotional role, mental health, energy and SF-36 total score in observation group were significantly higher than those in control group(P<0.01).Conclusions:The diversified health care modes can improve the education on disease knowledge, shorten the catheter and hospital time, and improve the quality of life and satisfaction of hemodialysis catheter patients.
Objective:To explore the effects of different nursing modes on the health knowledge and indwelling time and quality of life in patients with hemodialysis catheter.Methods:Eighty-two hemodialysis patients were randomly divided into the control group(n=41)and observation group(n=41).The control group were nursed with routine care, and the observation group were treated with diversified health education based on routine care.The health knowledge awareness, indwelling time, hospital stay, satisfaction and quality of life between two groups were compared and analyzed.Results:The awareness rates of diet, self-testing disease, complication management, medication and exercise in observation group were significantly higher than those in control group(P<0.01).The indwelling time, average length of stay and satisfaction scores in observation group were better than those in control group(P<0.01).After treatment, the physiological function, bodily pain, general health, physical function, social function, emotional role, mental health, energy and SF-36 total score in observation group were significantly higher than those in control group(P<0.01).Conclusions:The diversified health care modes can improve the education on disease knowledge, shorten the catheter and hospital time, and improve the quality of life and satisfaction of hemodialysis catheter patients.
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