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2015 Vol. 40, No. 7
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2015, 39(7): 841-844.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.001
Abstract:
Objective:To observe the effects of Artemisiae capillaris on the expressions of multidrug resistance-associated protein 3(MRP3) and nuclear pregnane X receptor(PXR) in normal rat liver.Methods:Ten male Sprague-Dawley(SD) rats were randomly divided into the Artemisiae capillaris group and control group(5 rats each group).The Artemisiae capillaris group and control group were treated with gavage of Artemisiae capillaris(100 mg·kg-1·d-1) and gavage of 0.9% sodium chloride.Two groups were sacrificed after 7 days.The morphological change of liver tissue was observed using HE staining,the total RNA and membrane or nuclear protein were extracted from the liver tissue of two groups.The mRNA and protein expressions of MRP3 and PXR were detected by Real-time PCR and Western blotting,respectively.Results:Compared with the control group,the morphological structure of liver tissue in Artemisiae capillaris group was not influenced.Artemisiae capillaris could significantly up-regulate the protein expressions of MRP3 and PXR in rat liver(PConclusions:Artemisiae capillaris can up-regulate the expression of MRP3 and PXR in rat liver.
Objective:To observe the effects of Artemisiae capillaris on the expressions of multidrug resistance-associated protein 3(MRP3) and nuclear pregnane X receptor(PXR) in normal rat liver.Methods:Ten male Sprague-Dawley(SD) rats were randomly divided into the Artemisiae capillaris group and control group(5 rats each group).The Artemisiae capillaris group and control group were treated with gavage of Artemisiae capillaris(100 mg·kg-1·d-1) and gavage of 0.9% sodium chloride.Two groups were sacrificed after 7 days.The morphological change of liver tissue was observed using HE staining,the total RNA and membrane or nuclear protein were extracted from the liver tissue of two groups.The mRNA and protein expressions of MRP3 and PXR were detected by Real-time PCR and Western blotting,respectively.Results:Compared with the control group,the morphological structure of liver tissue in Artemisiae capillaris group was not influenced.Artemisiae capillaris could significantly up-regulate the protein expressions of MRP3 and PXR in rat liver(PConclusions:Artemisiae capillaris can up-regulate the expression of MRP3 and PXR in rat liver.
2015, 39(7): 844-846.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.002
Abstract:
Objective:To compare the effects of osteoclasts on the absorption activities of the bovine cortical bone slices and dentine discs.Methods:Osteoclasts were harvested from RAW264.7 cells induced by 25 ng/ml M-CSF combined with 30 ng/ml RANKL,which was cocultured with bovine cortical bone slices and dentine discs,respectively.The number of positive cells and area of resorption lacunae were detected by antitartaric acid phosphatase staining,and the absorption activities of different substrates were compared.Results:The difference of the TRAP positive cells in different substrates coculture was not statistically significant(P>0.05).The area of resorption lacunae in bovine cortical bone slices was significantly more than that in dentine discs(PConclusions:Compared with the dentine discs,the absorption activity of osteoclasts on bovine cortical bone slices is strong.
Objective:To compare the effects of osteoclasts on the absorption activities of the bovine cortical bone slices and dentine discs.Methods:Osteoclasts were harvested from RAW264.7 cells induced by 25 ng/ml M-CSF combined with 30 ng/ml RANKL,which was cocultured with bovine cortical bone slices and dentine discs,respectively.The number of positive cells and area of resorption lacunae were detected by antitartaric acid phosphatase staining,and the absorption activities of different substrates were compared.Results:The difference of the TRAP positive cells in different substrates coculture was not statistically significant(P>0.05).The area of resorption lacunae in bovine cortical bone slices was significantly more than that in dentine discs(PConclusions:Compared with the dentine discs,the absorption activity of osteoclasts on bovine cortical bone slices is strong.
2015, 39(7): 847-850.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.003
Abstract:
Objective:To study the relationship between the properties and the structure of the wavelike sheet zinc coordination polymer,and explore the preparation method of new fluorescence materials.Methods:Under solvothermal conditions,the assembly of 4,4'-bis(benzimidazol-1-ylmethy1)biphenyl,4,4'-dicarboxydiphenyl sulfone and Zn(NO3)2·6H2O resulting a new complex[Zn(C14H18SO6)(C28H22N4)]n.The complex has been characterized by single crystal X-ray structure analyses,thermogravimetric analyses,powder X-ray diffraction and solid-state photoluminescent measurements.Results:The complex has a wavelike sheet framework and exists intense fluorescent emissions with a maximum peak of 379 nm(λex=298 nm),which should result from the π-π interaction between benzimidazol rings.Conclusions:A new coordination polymer have been synthesized and the fluorescent properties well studied,to provide approaches for the design and exploitation of new fluorescence materials.
Objective:To study the relationship between the properties and the structure of the wavelike sheet zinc coordination polymer,and explore the preparation method of new fluorescence materials.Methods:Under solvothermal conditions,the assembly of 4,4'-bis(benzimidazol-1-ylmethy1)biphenyl,4,4'-dicarboxydiphenyl sulfone and Zn(NO3)2·6H2O resulting a new complex[Zn(C14H18SO6)(C28H22N4)]n.The complex has been characterized by single crystal X-ray structure analyses,thermogravimetric analyses,powder X-ray diffraction and solid-state photoluminescent measurements.Results:The complex has a wavelike sheet framework and exists intense fluorescent emissions with a maximum peak of 379 nm(λex=298 nm),which should result from the π-π interaction between benzimidazol rings.Conclusions:A new coordination polymer have been synthesized and the fluorescent properties well studied,to provide approaches for the design and exploitation of new fluorescence materials.
2015, 39(7): 851-853.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.004
Abstract:
Objective:To observe the role of docosahexaenoic acid(DHA) on anti-pulmonary hypertension in rats and on apoptosis in pulmonary artery smooth muscle cells.Methods:Male Sprague-Dawley(SD) rats(200 to 250g) were randomly divided into control normoxic group,chronic intermittent hypoxic group and DHA-treated group.The hypoxic pulmonary hypertension model was made by chronic intermittent hypoxic method,mean pulmonary arterial pressure was measured by right heart catheterization,the right ventricle index was calculated through weighing the left and right ventricles accurately,the apoptosis rate of pulmonary artery smooth muscle cells was determined by TdT-mediated dVTP nick-end labeling method,Caspase 3 and Caspase 9 activities were measured by activity assay kits.Results:Compared with the control normoxic group,in hypoxia group,mean pulmonary arterial pressure and right ventricular index were significantly increased(PPPPConclusions:DHA has the anti-pulmonary hypertension effect in rats,the mechanism may be associated with promoting apoptosis happening of pulmonary artery smooth muscle cells.
Objective:To observe the role of docosahexaenoic acid(DHA) on anti-pulmonary hypertension in rats and on apoptosis in pulmonary artery smooth muscle cells.Methods:Male Sprague-Dawley(SD) rats(200 to 250g) were randomly divided into control normoxic group,chronic intermittent hypoxic group and DHA-treated group.The hypoxic pulmonary hypertension model was made by chronic intermittent hypoxic method,mean pulmonary arterial pressure was measured by right heart catheterization,the right ventricle index was calculated through weighing the left and right ventricles accurately,the apoptosis rate of pulmonary artery smooth muscle cells was determined by TdT-mediated dVTP nick-end labeling method,Caspase 3 and Caspase 9 activities were measured by activity assay kits.Results:Compared with the control normoxic group,in hypoxia group,mean pulmonary arterial pressure and right ventricular index were significantly increased(PPPPConclusions:DHA has the anti-pulmonary hypertension effect in rats,the mechanism may be associated with promoting apoptosis happening of pulmonary artery smooth muscle cells.
2015, 39(7): 854-856.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.005
Abstract:
Objective:To observe the pathological damage of the skin and tissue of the compression parts after different time of compression in rats.Methods:Sixty-five Sprague-Dawley rats were randomly divided into the six groups(8 rats each group),which included the control group(group A,without compression),group B(compression for 1 h),group C(compression for 2 h),group D(compression for 3 h),group E(compression for 4 h) and group F(compression for 6 h).The time of compression and compression interval in all groups were the same,and the whole course was 24 h.The pathological damage of the skin and tissue of compression parts were observed after compression.Results:Erythema in 1 rat of group B,2 rats of group C,5 rats of group D,8 rats of group E and 8 rats group F were found.The number of erythema in group D,E and F were significantly more than that in group A(PConclusions:The damage of the skin and tissue of compression parts is obvious after 2 h of compression,skin damage is more serians when the pressure is prolonged.
Objective:To observe the pathological damage of the skin and tissue of the compression parts after different time of compression in rats.Methods:Sixty-five Sprague-Dawley rats were randomly divided into the six groups(8 rats each group),which included the control group(group A,without compression),group B(compression for 1 h),group C(compression for 2 h),group D(compression for 3 h),group E(compression for 4 h) and group F(compression for 6 h).The time of compression and compression interval in all groups were the same,and the whole course was 24 h.The pathological damage of the skin and tissue of compression parts were observed after compression.Results:Erythema in 1 rat of group B,2 rats of group C,5 rats of group D,8 rats of group E and 8 rats group F were found.The number of erythema in group D,E and F were significantly more than that in group A(PConclusions:The damage of the skin and tissue of compression parts is obvious after 2 h of compression,skin damage is more serians when the pressure is prolonged.
2015, 39(7): 857-859,862.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.006
Abstract:
Objective:To observe the level of the plasma adrenomedullin(ADM) in patients with chronic obstructive pulmonary disease(COPD),and investigate the correlation of ADM with COPD.Methods:The patients with COPD were divided into the acute exacerbated COPD group and stable COPD group,and the healthy people were set as the control group(23 cases each group).The plasma ADM levels,pulmonary function,blood gas analysis and blood routine test among three groups were compared.Results:The levels of plasma ADM in acute exacerbated COPD group and stable COPD group were significantly higher than that in control group(PPPPConclusions:With the deterioration of COPD patients,the ADM compensatory increasing can expand the airway,inhibit the inflammation reaction and delay disease progression.
Objective:To observe the level of the plasma adrenomedullin(ADM) in patients with chronic obstructive pulmonary disease(COPD),and investigate the correlation of ADM with COPD.Methods:The patients with COPD were divided into the acute exacerbated COPD group and stable COPD group,and the healthy people were set as the control group(23 cases each group).The plasma ADM levels,pulmonary function,blood gas analysis and blood routine test among three groups were compared.Results:The levels of plasma ADM in acute exacerbated COPD group and stable COPD group were significantly higher than that in control group(PPPPConclusions:With the deterioration of COPD patients,the ADM compensatory increasing can expand the airway,inhibit the inflammation reaction and delay disease progression.
2015, 39(7): 859-862.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.007
Abstract:
Objective:To compare the anticoagulative effects and safety between argatroban and heparin in continuous veno-venous hemofiltration(CVVH) therapy.Methods:Forty renal insufficiency patients were randomly divided into the argatroban group and heparin group(20 cases each group).The argatroban group and heparin group were treated with argatroban and heparin,respectively.The platelet(PLT) and renal function before and after treatment,and activated partial thromboplastin time(APTT)after 1,4 and 8 h of the beginning of treatment,before the end of treatment and after 1h of treatment were detected.The blood coagulation of pipe and filter during treatment,and bleeding after 24 h of the end of treatment were observed.Results:Compared with before treatment,the number of PLT in heparin group decreased dramatically(PP>0.05).The differences of APTT between argatroban group and heparin group after CVVH and before the end of treatment were statistically significant(PP>0.05),but for heparin group,the APPT was still higher than that before treatment(PPP>0.05).Conclusions:The anticoagulative effect of argatroban in CVVH treatment is similar to the heparin,the recovery of CVVH is quick after stopping drug.The argatroban is good effect and high safety,which maybe an ideal anticoagulant in CVVH treatment.
Objective:To compare the anticoagulative effects and safety between argatroban and heparin in continuous veno-venous hemofiltration(CVVH) therapy.Methods:Forty renal insufficiency patients were randomly divided into the argatroban group and heparin group(20 cases each group).The argatroban group and heparin group were treated with argatroban and heparin,respectively.The platelet(PLT) and renal function before and after treatment,and activated partial thromboplastin time(APTT)after 1,4 and 8 h of the beginning of treatment,before the end of treatment and after 1h of treatment were detected.The blood coagulation of pipe and filter during treatment,and bleeding after 24 h of the end of treatment were observed.Results:Compared with before treatment,the number of PLT in heparin group decreased dramatically(PP>0.05).The differences of APTT between argatroban group and heparin group after CVVH and before the end of treatment were statistically significant(PP>0.05),but for heparin group,the APPT was still higher than that before treatment(PPP>0.05).Conclusions:The anticoagulative effect of argatroban in CVVH treatment is similar to the heparin,the recovery of CVVH is quick after stopping drug.The argatroban is good effect and high safety,which maybe an ideal anticoagulant in CVVH treatment.
2015, 39(7): 863-865.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.008
Abstract:
Objective:To investigate the changes of serum paraoxonase-1(PON-1) activity,oxidized low-density lipoprotein(ox-LDL) level in acute ischemic stroke patients and analyze the clinical significance.Methods:Ninety-six acute ischemic stroke cases and 72 health subjects were selected.Serum PON-1 activity was measured using paroxon as substrate and ox-LDL level was detected by enzyme-linked immuno sorbent assay method.Total cholesterol,triglyceride,high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol levels were all measured in the two groups.The relationships of serum PON-1 activity,ox-LDL level and acute ischemic stroke were explored.Results:In ischemic stroke group,serum PON-1 activity and high-density lipoprotein-cholesterol level were significantly lower than those in control group( PPPPPPPPConclusions:In the patients with acute ischemic stroke,serum PON-1 activity was decreased and ox-LDL level was increased,the changes may be an important risk factor for ischemic stroke.It has an important meaning to forecast the risk of ischemic stroke.
Objective:To investigate the changes of serum paraoxonase-1(PON-1) activity,oxidized low-density lipoprotein(ox-LDL) level in acute ischemic stroke patients and analyze the clinical significance.Methods:Ninety-six acute ischemic stroke cases and 72 health subjects were selected.Serum PON-1 activity was measured using paroxon as substrate and ox-LDL level was detected by enzyme-linked immuno sorbent assay method.Total cholesterol,triglyceride,high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol levels were all measured in the two groups.The relationships of serum PON-1 activity,ox-LDL level and acute ischemic stroke were explored.Results:In ischemic stroke group,serum PON-1 activity and high-density lipoprotein-cholesterol level were significantly lower than those in control group( PPPPPPPPConclusions:In the patients with acute ischemic stroke,serum PON-1 activity was decreased and ox-LDL level was increased,the changes may be an important risk factor for ischemic stroke.It has an important meaning to forecast the risk of ischemic stroke.
2015, 39(7): 866-868.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.009
Abstract:
Objective:To investigate the effects of atorvastatin on the blood lipid level and renal blood flow parameters in patients with diabetic nephropathy.Methods:Sixty-eight patients with diabetic nephropathy were randomly divided into the conventional treatment group(34 cases,control group) and conventional treatment combined with atorvastatin group(34 cases,observation group) according to the random allocation.The blood lipid level and renal blood flow parameters in two groups were analyzed before treatment and after 4,8 and 12 weeks of treatment.Results:The blood lipid levels in observation group after 4,8 and 12 weeks of treatment were significantly better than those in control group(PPConclusions:The atorvastatin has significantly effects on the blood lipid and renal blood flow parameters in patients with diabetic nephropathy,which is conducive to the improvement of diabetic nephropathy state.
Objective:To investigate the effects of atorvastatin on the blood lipid level and renal blood flow parameters in patients with diabetic nephropathy.Methods:Sixty-eight patients with diabetic nephropathy were randomly divided into the conventional treatment group(34 cases,control group) and conventional treatment combined with atorvastatin group(34 cases,observation group) according to the random allocation.The blood lipid level and renal blood flow parameters in two groups were analyzed before treatment and after 4,8 and 12 weeks of treatment.Results:The blood lipid levels in observation group after 4,8 and 12 weeks of treatment were significantly better than those in control group(PPConclusions:The atorvastatin has significantly effects on the blood lipid and renal blood flow parameters in patients with diabetic nephropathy,which is conducive to the improvement of diabetic nephropathy state.
2015, 39(7): 869-871,873.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.010
Abstract:
Objective:To explore the effects of repaglinide combined with acarbose in the treatment of type 2 diabetes mellitus.Methods:Eighty-six patients with type 2 diabetes were randomly divided into the control group and observation group,43 cases in each group.The control group and observation group were treated with repaglinide and repaglinide combined with acarbose for 4 weeks,respectively.The clinical effects,changes of pysiological idexes and safety between two groups were compared.Results:After treatment,the clinical total effective rates in control group and observation group were 76.7% and 97.7%,respectively,the difference of which was statistically significant(PPP>0.05).Conclusions:The treatment of type 2 diabetes with repaglinide combined with acarbose can significantly improve the main physiological indexes and clinical treatment effects,and the safety of which is good.
Objective:To explore the effects of repaglinide combined with acarbose in the treatment of type 2 diabetes mellitus.Methods:Eighty-six patients with type 2 diabetes were randomly divided into the control group and observation group,43 cases in each group.The control group and observation group were treated with repaglinide and repaglinide combined with acarbose for 4 weeks,respectively.The clinical effects,changes of pysiological idexes and safety between two groups were compared.Results:After treatment,the clinical total effective rates in control group and observation group were 76.7% and 97.7%,respectively,the difference of which was statistically significant(PPP>0.05).Conclusions:The treatment of type 2 diabetes with repaglinide combined with acarbose can significantly improve the main physiological indexes and clinical treatment effects,and the safety of which is good.
2015, 39(7): 871-873.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.011
Abstract:
Objective:To compare the effects of the airway management between the jaw support ventilation and oropharyngeal airway ventilation in obese patients during the general anesthetic recovery.Methods:Forty obese patients scheduled by general anesthesia were randomly divided into the jaw support ventilation group(group A) and oropharyngeal airway ventilation group(group B)(20 cases each group).The group A and B were treated with the jaw support ventilation and oral pharyngeal airway ventilation after tracheal extubation,respectively.Two groups were treated with mask oxygen inhalation(oxygen flow min/2L) until awaking,and the further measures were taken when the pulse oxygen saturation(SpO2) was less than 90%.The changes of SpO2,respiratory rate(RR),mean arterial pressure(MAP),heart rate(HR) were observed,and the occurrence of restlessness,nausea,vomiting and laryngospasm were recorded at the beginning of entering the postoperative recovery room(T1),after 5 min(T2),10 min(T3),20 min(T4) of different modes of ventilation.Results:The levels of RR,MAP,HR and SpO2 were remained in the normal range.The differences of the SpO2 at each time-points between two groups were not statistically significant(P>0.05).The HR in group A was significantly less than that in group B at T2 and T3(P2,T3 and T4(PPP>0.05).Conclusions:The application effects between the jaw support ventilation and oropharyngeal airway ventilation in obese patients during the general anesthetic recovery are same.The effects of the jaw support ventilation on the vital signs and its complication of patients are less.
Objective:To compare the effects of the airway management between the jaw support ventilation and oropharyngeal airway ventilation in obese patients during the general anesthetic recovery.Methods:Forty obese patients scheduled by general anesthesia were randomly divided into the jaw support ventilation group(group A) and oropharyngeal airway ventilation group(group B)(20 cases each group).The group A and B were treated with the jaw support ventilation and oral pharyngeal airway ventilation after tracheal extubation,respectively.Two groups were treated with mask oxygen inhalation(oxygen flow min/2L) until awaking,and the further measures were taken when the pulse oxygen saturation(SpO2) was less than 90%.The changes of SpO2,respiratory rate(RR),mean arterial pressure(MAP),heart rate(HR) were observed,and the occurrence of restlessness,nausea,vomiting and laryngospasm were recorded at the beginning of entering the postoperative recovery room(T1),after 5 min(T2),10 min(T3),20 min(T4) of different modes of ventilation.Results:The levels of RR,MAP,HR and SpO2 were remained in the normal range.The differences of the SpO2 at each time-points between two groups were not statistically significant(P>0.05).The HR in group A was significantly less than that in group B at T2 and T3(P2,T3 and T4(PPP>0.05).Conclusions:The application effects between the jaw support ventilation and oropharyngeal airway ventilation in obese patients during the general anesthetic recovery are same.The effects of the jaw support ventilation on the vital signs and its complication of patients are less.
2015, 39(7): 874-876,878.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.012
Abstract:
Objective:To explore the application of the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl transpeptidase(GGT),alkaline phosphatase(ALP) and total bilirubin(TBIL) in the differential diagnosis of primary hepatocellular carcinoma(HCC) and intrahepatic colangiocarcinoma(ICC).Methods:The serum levels of ALT,AST,GGT,ALP and TBIL in 98 patients with HCC and 125 patients with ICC were detected and analyzed.Results:The serum levels of ALT,AST,GGT,ALP and TBIL in ICC group were significantly higher than those in HCC group(PPPPConclusions:The serum levels of ALT,AST,GGT,ALP and TBIL in ICC group increase significantly,which has important value in the differential diagnosis of hepatocellular carcinoma and intrahepatic colangiocarcinoma.
Objective:To explore the application of the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),glutamyl transpeptidase(GGT),alkaline phosphatase(ALP) and total bilirubin(TBIL) in the differential diagnosis of primary hepatocellular carcinoma(HCC) and intrahepatic colangiocarcinoma(ICC).Methods:The serum levels of ALT,AST,GGT,ALP and TBIL in 98 patients with HCC and 125 patients with ICC were detected and analyzed.Results:The serum levels of ALT,AST,GGT,ALP and TBIL in ICC group were significantly higher than those in HCC group(PPPPConclusions:The serum levels of ALT,AST,GGT,ALP and TBIL in ICC group increase significantly,which has important value in the differential diagnosis of hepatocellular carcinoma and intrahepatic colangiocarcinoma.
2015, 39(7): 876-878.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.013
Abstract:
Objective:To detect the levels of serum homocysteine(Hcy) and fibrinogen(FIB) in type 2 diabetes mellitus(T2DM) patients complicated with cerebral infarction.Methods:Seventy T2DM patients were divided into the cerebral infarction group(45 cases complicated with cerebral infarction) and simple T2DM group(25 cases),20 healthy people were set as the control group.The levels of serum Hcy and FIB in all cases were detected.Results:The levels of serum Hcy and FIB in cerebral infarction group were higher than those in T2DM group and control group(PPPConclusions:The levels of serum Hcy and FIB in T2DM patients complicated with cerebral infarction significantly increase,which may be the patients' independent risk factors.
Objective:To detect the levels of serum homocysteine(Hcy) and fibrinogen(FIB) in type 2 diabetes mellitus(T2DM) patients complicated with cerebral infarction.Methods:Seventy T2DM patients were divided into the cerebral infarction group(45 cases complicated with cerebral infarction) and simple T2DM group(25 cases),20 healthy people were set as the control group.The levels of serum Hcy and FIB in all cases were detected.Results:The levels of serum Hcy and FIB in cerebral infarction group were higher than those in T2DM group and control group(PPPConclusions:The levels of serum Hcy and FIB in T2DM patients complicated with cerebral infarction significantly increase,which may be the patients' independent risk factors.
2015, 39(7): 879-882.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.014
Abstract:
Objective:To explore the operation methods and clinical effects of intramedullary fixation under the manual tranction reduction in the treatment of femoral intertrochanteric fractures.Methods:The clinical data of 35 patients with femoral intertrochanteric fractures were retrospectively analyzed.All patients were treated with intramedullary fixation under the manual tranction reduction,the intraoperative blood loss was observed.The fracture healing and myositis ossificans occurrence were detected by radiograpy at postoperative l,3,6 months and 1 year.The hip joint function recovery of patient was evaluated using Harris scoring system.Results:Among 35 patients,30 cases were followed up for 1 to 59 months.30 cases were treated with PFNA,1 case was treated with PFNA combined with femoral neck pressure hollow screw nails and 4 cases were treated with intertan nails.Closed reduction in 31 cases and open reduction in 4 cases were implemented.According to the Harris score,16 cases were excellent,10 cases were good,3 cases were fair and 1 case was bad,the excellent and good rate of which was 86.7%.One case was accompanied with femoral medial cortical bone fracture during operation.One case was lacunar cerebral infarction at postoperative 2 days,and it recovered after symptomatic treatment.Among 30 cases with following-up,there was not infection and internal fixation failure,and all the fractures healed.The distal fractures of internal fixation in 1 case was caused by car accident.Conclusions:Intramedullary fixation is an effective method for treating the femoral intertrochanteric fractures.Unarmed manual traction reset can also achieve the ideal treatment effect,but the operation skills should be paid more attention to.
Objective:To explore the operation methods and clinical effects of intramedullary fixation under the manual tranction reduction in the treatment of femoral intertrochanteric fractures.Methods:The clinical data of 35 patients with femoral intertrochanteric fractures were retrospectively analyzed.All patients were treated with intramedullary fixation under the manual tranction reduction,the intraoperative blood loss was observed.The fracture healing and myositis ossificans occurrence were detected by radiograpy at postoperative l,3,6 months and 1 year.The hip joint function recovery of patient was evaluated using Harris scoring system.Results:Among 35 patients,30 cases were followed up for 1 to 59 months.30 cases were treated with PFNA,1 case was treated with PFNA combined with femoral neck pressure hollow screw nails and 4 cases were treated with intertan nails.Closed reduction in 31 cases and open reduction in 4 cases were implemented.According to the Harris score,16 cases were excellent,10 cases were good,3 cases were fair and 1 case was bad,the excellent and good rate of which was 86.7%.One case was accompanied with femoral medial cortical bone fracture during operation.One case was lacunar cerebral infarction at postoperative 2 days,and it recovered after symptomatic treatment.Among 30 cases with following-up,there was not infection and internal fixation failure,and all the fractures healed.The distal fractures of internal fixation in 1 case was caused by car accident.Conclusions:Intramedullary fixation is an effective method for treating the femoral intertrochanteric fractures.Unarmed manual traction reset can also achieve the ideal treatment effect,but the operation skills should be paid more attention to.
2015, 39(7): 883-886,888.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.015
Abstract:
Objective:To investigate the effects of phacoemulsification combined with implanting different aspheric intraocular lens on postoperative visual acuity and contrast sensitivity.Methods:Ninety-six cataract eyes(72 patients) were divided into group A,B and C.All cases were treated with phacoemulsification combined with implanting different aspheric intraocular lens.The AcrySof ReSTOR plus 3D(SN6AD1) aspheric multifocal intraocular lens,AcrySof ReSTOR plus 4D(SN6AD3) and monofocal intraocular lens were used in group A,B and C,respectively.The naked eye and corrected visual acuity,and contrast sensitivity in different lighting conditions and spatial frequency between 3 groups were compared at postoperative 1 day,1 week and 1 month.Results:The naked eye visual acuity in group A at postoperative 1 day,1 week and 1 month was significantly better than that in group B and group C(PP>0.05).The contrast sensitivities in group A and group B under non-glare(3 cd/m2) and 3 c/d and 6 c/d low spatial frequency were better than that in group C(P2) were better than that in group C(PConclusions:The phacoemulsification combined with implanting intraocular lens can significantly improve the visual quality of cataract patients.Compared with the monofocal intraocular lens,the effect of aspheric multifocal intraocular lens on improving the contrast sensitivity is better.The AcrySof ReSTOR plus 3D(SN6AD1) aspheric multifocal intraocular lens can significantly improve the distance vision of patients,which is worthy of clinical application.
Objective:To investigate the effects of phacoemulsification combined with implanting different aspheric intraocular lens on postoperative visual acuity and contrast sensitivity.Methods:Ninety-six cataract eyes(72 patients) were divided into group A,B and C.All cases were treated with phacoemulsification combined with implanting different aspheric intraocular lens.The AcrySof ReSTOR plus 3D(SN6AD1) aspheric multifocal intraocular lens,AcrySof ReSTOR plus 4D(SN6AD3) and monofocal intraocular lens were used in group A,B and C,respectively.The naked eye and corrected visual acuity,and contrast sensitivity in different lighting conditions and spatial frequency between 3 groups were compared at postoperative 1 day,1 week and 1 month.Results:The naked eye visual acuity in group A at postoperative 1 day,1 week and 1 month was significantly better than that in group B and group C(PP>0.05).The contrast sensitivities in group A and group B under non-glare(3 cd/m2) and 3 c/d and 6 c/d low spatial frequency were better than that in group C(P2) were better than that in group C(PConclusions:The phacoemulsification combined with implanting intraocular lens can significantly improve the visual quality of cataract patients.Compared with the monofocal intraocular lens,the effect of aspheric multifocal intraocular lens on improving the contrast sensitivity is better.The AcrySof ReSTOR plus 3D(SN6AD1) aspheric multifocal intraocular lens can significantly improve the distance vision of patients,which is worthy of clinical application.
2015, 39(7): 886-888.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.016
Abstract:
Objective:To explore the clinical application value of the intravenous continuous analgesia combined with internal fixation of ribs in the treatment of multiple fractures of multiple ribs.Methods:Fifty-four multiple fractures of multiple ribs patients were treated with the intravenous continuous analgesia for 4 to 10 days combined with internal fixation using rib claw plate during the perioperative period.Four cases were urgently operated,50 cases were operated after 2 to 5 d of injury.Results:The postoperative X-ray of chest showed that the contraposition of internal fixation of rib fractures,and lung recruitment were good,and no drug addiction case was found.StageⅠhealing in 51 cases and stage Ⅱ healing in 3 cases,and all cases cured.Fifty-two cases were followed up for 4 to 41 months.All X-ray of chest showed the rib fracture line disappeared,and no obvious chest deformity.All patients returned to normal life and work.Conclusions:The treatment of multiple fractures of multiple ribs with internal fixation using rib claw plate combined with continuous intravenous analgesia is safe and effective,low pain and good compliance,and which can obviously decrease the effects on respiratory system and circulatory system,and increase the satisfaction of patients.
Objective:To explore the clinical application value of the intravenous continuous analgesia combined with internal fixation of ribs in the treatment of multiple fractures of multiple ribs.Methods:Fifty-four multiple fractures of multiple ribs patients were treated with the intravenous continuous analgesia for 4 to 10 days combined with internal fixation using rib claw plate during the perioperative period.Four cases were urgently operated,50 cases were operated after 2 to 5 d of injury.Results:The postoperative X-ray of chest showed that the contraposition of internal fixation of rib fractures,and lung recruitment were good,and no drug addiction case was found.StageⅠhealing in 51 cases and stage Ⅱ healing in 3 cases,and all cases cured.Fifty-two cases were followed up for 4 to 41 months.All X-ray of chest showed the rib fracture line disappeared,and no obvious chest deformity.All patients returned to normal life and work.Conclusions:The treatment of multiple fractures of multiple ribs with internal fixation using rib claw plate combined with continuous intravenous analgesia is safe and effective,low pain and good compliance,and which can obviously decrease the effects on respiratory system and circulatory system,and increase the satisfaction of patients.
2015, 39(7): 889-893,895.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.017
Abstract:
Objective:To analyze the incidence,risk factors and preventive treatment of postpartum hemorrhage(PPH) for providing the clinical data in improving the prevention measures of PPH.Methods:The data of pregnant women from January to December 2002,from September 2007 to May 2008 and from January to December 2012 were retrospectively analyzed.The 300 cases(group A),596 cases(group B) and 598 cases(group C) from three corresponding time period were selected by systematic random sampling.The incidence of PPH and severe PPH(SPPH),hemoglobin(Hb) before and after delivery,risk factors of PPH,drug and hemostasis between three groups were analyzed.Results:The differences of the incidence of PPH and SPPH between the patients with vaginal delivery and cesarean delivery were not statistically significant(P>0.05).The incidence of PPH in patients with cesarean delivery in group B was higher than that in patients with vaginal delivery(PP>0.05).The amount of bleeding in 3 groups with cesarean delivery was higher than that in vaginal delivery(PPPPPConclusions:The amount of bleeding estimated by traditional method is low,the effective and timely method should be used to estimate the amount of bleeding.The trend of placenta previa and macrosomia can lead to the SPPH.Reducing the unreasonable cesarean section and inproving health care during pregnancy can help to reduce the PPH.
Objective:To analyze the incidence,risk factors and preventive treatment of postpartum hemorrhage(PPH) for providing the clinical data in improving the prevention measures of PPH.Methods:The data of pregnant women from January to December 2002,from September 2007 to May 2008 and from January to December 2012 were retrospectively analyzed.The 300 cases(group A),596 cases(group B) and 598 cases(group C) from three corresponding time period were selected by systematic random sampling.The incidence of PPH and severe PPH(SPPH),hemoglobin(Hb) before and after delivery,risk factors of PPH,drug and hemostasis between three groups were analyzed.Results:The differences of the incidence of PPH and SPPH between the patients with vaginal delivery and cesarean delivery were not statistically significant(P>0.05).The incidence of PPH in patients with cesarean delivery in group B was higher than that in patients with vaginal delivery(PP>0.05).The amount of bleeding in 3 groups with cesarean delivery was higher than that in vaginal delivery(PPPPPConclusions:The amount of bleeding estimated by traditional method is low,the effective and timely method should be used to estimate the amount of bleeding.The trend of placenta previa and macrosomia can lead to the SPPH.Reducing the unreasonable cesarean section and inproving health care during pregnancy can help to reduce the PPH.
2015, 39(7): 893-895.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.018
Abstract:
Objective:To discuss the curative effects of antibiotics combined with fuke qianjin tablets on endometritis.Methods:One hundred and sixty cases of endometritis were randomly divided into observation group and control group(n=80 in each).The cases in the control group received the traditional treatment of oral antibiotics and artificial cycleestrogen combined with vagina flushing,while the cases in the observation group were administered fuke qianjin tablets in addition to the traditional therapy.The clinical symptoms and signs of improvement,gynecology ultrasound and endometrium thickness were observed and compared between the two groups.Results:The menstrual quantity and menstrual cycles of the observation group improved significantly compared to those of the control group(PPPPPPConclusions:Antibiotics combined with fuke qianjin tablets could effectively improve the clinical symptoms and signs as well as promoting the restoration of endometrium of patients with endometritis.
Objective:To discuss the curative effects of antibiotics combined with fuke qianjin tablets on endometritis.Methods:One hundred and sixty cases of endometritis were randomly divided into observation group and control group(n=80 in each).The cases in the control group received the traditional treatment of oral antibiotics and artificial cycleestrogen combined with vagina flushing,while the cases in the observation group were administered fuke qianjin tablets in addition to the traditional therapy.The clinical symptoms and signs of improvement,gynecology ultrasound and endometrium thickness were observed and compared between the two groups.Results:The menstrual quantity and menstrual cycles of the observation group improved significantly compared to those of the control group(PPPPPPConclusions:Antibiotics combined with fuke qianjin tablets could effectively improve the clinical symptoms and signs as well as promoting the restoration of endometrium of patients with endometritis.
2015, 39(7): 896-898.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.019
Abstract:
Objective:This paper offers a summarization of the operation skills and outcomes of hip replacement as a treatment of femoral head necrosis in Phase Ⅲ and Phase Ⅳ of Ficat. Methods:The method involves a retrospective analysis of clinical data with regard to 23 patients undergoing hip replacement, with a comparison of Harris grading of hip joint function and the improvement in flexion and abduction before and after the operation. Results:The outcome of the operation has established that the patients have obvious improvement in flexion and abduction, as well as in Harris grading (pConclusions:To sum up, hip replacement, which requires an overall,checkup before the operation, a cautious handling in the operation and a precaution against complication after the operation, serves as a good treatment of femoral head necrosis in Phase Ⅲ and Phase Ⅳ of Ficat.
Objective:This paper offers a summarization of the operation skills and outcomes of hip replacement as a treatment of femoral head necrosis in Phase Ⅲ and Phase Ⅳ of Ficat. Methods:The method involves a retrospective analysis of clinical data with regard to 23 patients undergoing hip replacement, with a comparison of Harris grading of hip joint function and the improvement in flexion and abduction before and after the operation. Results:The outcome of the operation has established that the patients have obvious improvement in flexion and abduction, as well as in Harris grading (pConclusions:To sum up, hip replacement, which requires an overall,checkup before the operation, a cautious handling in the operation and a precaution against complication after the operation, serves as a good treatment of femoral head necrosis in Phase Ⅲ and Phase Ⅳ of Ficat.
2015, 39(7): 899-901.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.020
Abstract:
Objective:To observe the curative effect and safety of insulin pump in intensive treatment of type 2 diabetes mellitus.Methods:Forty patients with type 2 diabetes mellitus were randomized to control group and treatment group.The control group were injected Novolin R before meals and insulin glargine at bedtime,while the treatment group received continuous subcutaneous insulin infusion with ultra-short-acting insulin lispro.The fasting blood glucose level,2-hour postprandial blood glucose,the time when blood glucose reached the standard,the dosage of insulin and the incidence of hypoglycemia of the patients in each group were respectively recorded before and after treatment.Results:The fasting blood glucose level and 2-hour postprandial blood glucose in both groups decreased obviously(PP>0.05).The contrast differences in the dosage of insulin were statistically significant(PP>0.05).Conclusions:Insulin pump continuous infusion is consistent with the physiological situation and good for controlling the blood glucose and lowering the incidence of hypoglycemia.This therapy is worth popularizing for treatment of diabetes mellitus.
Objective:To observe the curative effect and safety of insulin pump in intensive treatment of type 2 diabetes mellitus.Methods:Forty patients with type 2 diabetes mellitus were randomized to control group and treatment group.The control group were injected Novolin R before meals and insulin glargine at bedtime,while the treatment group received continuous subcutaneous insulin infusion with ultra-short-acting insulin lispro.The fasting blood glucose level,2-hour postprandial blood glucose,the time when blood glucose reached the standard,the dosage of insulin and the incidence of hypoglycemia of the patients in each group were respectively recorded before and after treatment.Results:The fasting blood glucose level and 2-hour postprandial blood glucose in both groups decreased obviously(PP>0.05).The contrast differences in the dosage of insulin were statistically significant(PP>0.05).Conclusions:Insulin pump continuous infusion is consistent with the physiological situation and good for controlling the blood glucose and lowering the incidence of hypoglycemia.This therapy is worth popularizing for treatment of diabetes mellitus.
2015, 39(7): 901-903.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.021
Abstract:
Objective:To investigate the clinicopathologic characteristics,immunohistochemistry staining and differential diagnosis of yolk sac tumor(YST) for providing the reference in the clinical diagnosis and treatment of YST.Methods:The pathologic characteristics in 16 YST cases diagnosed by operation and pathology were analyzed using HE staining and immunohistochemical technique.Results:Among 16 cases with YST,4 cases in testis,6 cases in ovary and 6 cases in extragonadal sites were found.Microscopically,the tumor cells arranging in loose reticular structure,Schiller-Duval bodies and hyaline droplets in the tumor tissue were detected.The positive expressions of cytokeratin and fetoprotein,human placental alkaline phosphatase and CD99,carcino-embryonic antigen and periodic ocid schiff in 16,8,1 and 12 cases were detected using immunohistochemistry,respectively.The expression of β-HCG in all cases were negative.Conclusions:YST is a rare disease,especially for happening in extragonadal sites.The clinical symptom of YST is not specific.The occurrence site,pathological features,immunohistochemistry and serum alpha-fetoprotein have important significance in the diagnosis and differential diagnosis of YST.
Objective:To investigate the clinicopathologic characteristics,immunohistochemistry staining and differential diagnosis of yolk sac tumor(YST) for providing the reference in the clinical diagnosis and treatment of YST.Methods:The pathologic characteristics in 16 YST cases diagnosed by operation and pathology were analyzed using HE staining and immunohistochemical technique.Results:Among 16 cases with YST,4 cases in testis,6 cases in ovary and 6 cases in extragonadal sites were found.Microscopically,the tumor cells arranging in loose reticular structure,Schiller-Duval bodies and hyaline droplets in the tumor tissue were detected.The positive expressions of cytokeratin and fetoprotein,human placental alkaline phosphatase and CD99,carcino-embryonic antigen and periodic ocid schiff in 16,8,1 and 12 cases were detected using immunohistochemistry,respectively.The expression of β-HCG in all cases were negative.Conclusions:YST is a rare disease,especially for happening in extragonadal sites.The clinical symptom of YST is not specific.The occurrence site,pathological features,immunohistochemistry and serum alpha-fetoprotein have important significance in the diagnosis and differential diagnosis of YST.
2015, 39(7): 904-907.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.022
Abstract:
Objective:To explore the influences of different doses of midazolam on anesthesia effects and revival quality of patients with lung cancer.Methods:Fifty-eight patients treated with lung cancer operation were randomly divided into the observation group and control group(29 cases each group) according to the random number table method.During the process of anesthesia induction,the observation group and control group were administered with 0.1 and 0.05 mg/kg of midazolam,respectively.Two groups were administered with 0.15 mg/kg of cisatracurium besilate,5 μg/kg of fentanyl and 0.3 mg/kg of Etomidate fat emulsion injection with the same dosage and usage.The anesthetic effect and revival quality in two groups were observed after 10 min of anesthesia induction(T1),start time of surgery(T2),after 30 min of surgery(T3),end time of surgery(T4) and after tracheal extubation(T5).Results:The levels of mean arterial pressure(MAP) and heart rate(HR) in the observation group from T1 to T5 gradually increased(PP2) level gradually increased from T1 to T3,then gradually decreased from T4 to T5(PP2 in the control group at different time-point were statistically significant(PP2 between T3 and T5 in the observation group were statistically significant(PPPP>0.05).Conclusions:The anesthesia effects of 0.1 mg/kg of midazolam on lung cancer surgery is better than that of 0.05 mg/kg of midazolam.The anesthesia with 0.1 mg/kg of midazolam has good analepsia quality and little effect on respiratory system,which is suitable for clinical application.
Objective:To explore the influences of different doses of midazolam on anesthesia effects and revival quality of patients with lung cancer.Methods:Fifty-eight patients treated with lung cancer operation were randomly divided into the observation group and control group(29 cases each group) according to the random number table method.During the process of anesthesia induction,the observation group and control group were administered with 0.1 and 0.05 mg/kg of midazolam,respectively.Two groups were administered with 0.15 mg/kg of cisatracurium besilate,5 μg/kg of fentanyl and 0.3 mg/kg of Etomidate fat emulsion injection with the same dosage and usage.The anesthetic effect and revival quality in two groups were observed after 10 min of anesthesia induction(T1),start time of surgery(T2),after 30 min of surgery(T3),end time of surgery(T4) and after tracheal extubation(T5).Results:The levels of mean arterial pressure(MAP) and heart rate(HR) in the observation group from T1 to T5 gradually increased(PP2) level gradually increased from T1 to T3,then gradually decreased from T4 to T5(PP2 in the control group at different time-point were statistically significant(PP2 between T3 and T5 in the observation group were statistically significant(PPPP>0.05).Conclusions:The anesthesia effects of 0.1 mg/kg of midazolam on lung cancer surgery is better than that of 0.05 mg/kg of midazolam.The anesthesia with 0.1 mg/kg of midazolam has good analepsia quality and little effect on respiratory system,which is suitable for clinical application.
2015, 39(7): 907-909.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.023
Abstract:
Objective:To explore the clinical features of preterm infants with fungal infection to improve the early diagnosis and treatment.Methods:The maternal pregnant history,neonatal birth history,clinical manifestation,labaratory examination and treatmnet outcome data of 42 preterm infants with fungemia were retrospectively analyzed.Results:Among 42 preterm infants,38 cases with equal to and less than 34 weeks gestational age and 25 cases with equal to and less than 1 500 g weight were found.The frequent apnea in 16 cases,grey skin in 11 cases,feeding intolerance in 8 cases and unexplained condition deteriorated rapidly in 13 cases were identified.The use antibiotics more than 10 days in 32 cases,intravenous nutrition in 35 cases and peripherally inserted central catheter in 18 cases were the morbidity factors.The laboratory test showed that thrombocytopenia decreased 45.2%,and CRP increased 38.1%.Conclusions:Little gestational age,low body mass,The antibiotics use,intravenous nutrition and peripherally inserted central catheter are the high risk factors in fungal infection of preterm infants.The clinical manifestations of fungal infection in preterm infants are atypical,which need to attach great importance to early diagnosis and timely treatment.
Objective:To explore the clinical features of preterm infants with fungal infection to improve the early diagnosis and treatment.Methods:The maternal pregnant history,neonatal birth history,clinical manifestation,labaratory examination and treatmnet outcome data of 42 preterm infants with fungemia were retrospectively analyzed.Results:Among 42 preterm infants,38 cases with equal to and less than 34 weeks gestational age and 25 cases with equal to and less than 1 500 g weight were found.The frequent apnea in 16 cases,grey skin in 11 cases,feeding intolerance in 8 cases and unexplained condition deteriorated rapidly in 13 cases were identified.The use antibiotics more than 10 days in 32 cases,intravenous nutrition in 35 cases and peripherally inserted central catheter in 18 cases were the morbidity factors.The laboratory test showed that thrombocytopenia decreased 45.2%,and CRP increased 38.1%.Conclusions:Little gestational age,low body mass,The antibiotics use,intravenous nutrition and peripherally inserted central catheter are the high risk factors in fungal infection of preterm infants.The clinical manifestations of fungal infection in preterm infants are atypical,which need to attach great importance to early diagnosis and timely treatment.
2015, 39(7): 910-912.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.024
Abstract:
Objective:To explore the predictive value of testosterone/estradiol(T/E2) in the effect of low doses of clomiphene in the treatment of idiopathic asthenospermia.Methods:Sixty patients with idiopathic asthenospermia were treated with small dose of clomiphene,and the treatment effect was observed.The sperm density,sperm activity rate,and the levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),T,E2 and T/E2 between before and after treatment were compared.Results:The clinical cure rate and total efficiency of the clomiphene in the treatment of idiopathic asthenospermia were 26.67% and 76.67%,respectively.Compared with before treatment,the sperm density,sperm activity rate,and the levels of FSH,LH,T and T/E2 increased significantly,but the E2 level decreased significantly after treatment(PConclusions:The sperm density,sperm activity rate,and the levels of FSH and LH are good indicators in evaluating the curative effect of low dose clomiphene in the treatment of idiopathic asthenospermia.The change of T/E2 together with other indicators can also be a comprehensive evaluation index in evaluating the effect of clomiphene.
Objective:To explore the predictive value of testosterone/estradiol(T/E2) in the effect of low doses of clomiphene in the treatment of idiopathic asthenospermia.Methods:Sixty patients with idiopathic asthenospermia were treated with small dose of clomiphene,and the treatment effect was observed.The sperm density,sperm activity rate,and the levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),T,E2 and T/E2 between before and after treatment were compared.Results:The clinical cure rate and total efficiency of the clomiphene in the treatment of idiopathic asthenospermia were 26.67% and 76.67%,respectively.Compared with before treatment,the sperm density,sperm activity rate,and the levels of FSH,LH,T and T/E2 increased significantly,but the E2 level decreased significantly after treatment(PConclusions:The sperm density,sperm activity rate,and the levels of FSH and LH are good indicators in evaluating the curative effect of low dose clomiphene in the treatment of idiopathic asthenospermia.The change of T/E2 together with other indicators can also be a comprehensive evaluation index in evaluating the effect of clomiphene.
2015, 39(7): 912-914.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.025
Abstract:
Objective:To investigate the safety and efficacy of dexmedetomidine(DEX)assisting anesthesia in children with tonsillectomy.Methods:Sixty children treated with tonsillectomy were randomly divided into the DEX assisting anesthesia group(DEX group) and the regular anesthesia group(control group)(30 cases in each group).The DEX group and control group were treated with 1 μg/kg of DEX and 0.9% sodium chloride injection by microinjection pump,respectively.The mean arterial pressure and heart rate in two groups were observed before injection,10 min after injection,the beginning of operation and end of operation.The amount of bleeding and consumption of fentanyl,respiratory depress,nausea and vomiting in two groups were recorded.Results:The efficacy of anesthesia in DEX group was better than that in control group(PPPConclusions:DEX assisting anesthesia can be used in tonsillectomy children,the good analgesia and sedation effects,stable circulation,quick palinesthesia and without respiratory depression are found.
Objective:To investigate the safety and efficacy of dexmedetomidine(DEX)assisting anesthesia in children with tonsillectomy.Methods:Sixty children treated with tonsillectomy were randomly divided into the DEX assisting anesthesia group(DEX group) and the regular anesthesia group(control group)(30 cases in each group).The DEX group and control group were treated with 1 μg/kg of DEX and 0.9% sodium chloride injection by microinjection pump,respectively.The mean arterial pressure and heart rate in two groups were observed before injection,10 min after injection,the beginning of operation and end of operation.The amount of bleeding and consumption of fentanyl,respiratory depress,nausea and vomiting in two groups were recorded.Results:The efficacy of anesthesia in DEX group was better than that in control group(PPPConclusions:DEX assisting anesthesia can be used in tonsillectomy children,the good analgesia and sedation effects,stable circulation,quick palinesthesia and without respiratory depression are found.
The epidemiological analysis of 2 140 cervical human papilloma virus infection cases in Fuyang Anhui
2015, 39(7): 915-917.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.026
Abstract:
Objective:To investigate the human papilloma virus(HPV) infection,and analyze the infection and distribution of 23 HPV subtypes in Fuyang area.Methods:The pathological diagnosis in 2 140 HPV detection women were implemented,the HPV subtype was analyzed using the flow-through hybridization and gene-chip.Results:The total infection,single infection and high-risk infection rates of HPV were 28.8%,58.3% and 22.9%,respectively.The most common types of HPV infections were in turn HPV16(21.4%),HPV 58(9.5%),HPV 52(7.3%),HPV 31(6.0%) and HPV 18(5.8%).The difference of the infection rates between high-risk type and each HPV subtype was not statistically significant(P>0.05).Conclusions:HPV16,52 and 58 types are the main infection type of HPV,the distribution of HPV subtype has regional specificity in Fuyang area.
Objective:To investigate the human papilloma virus(HPV) infection,and analyze the infection and distribution of 23 HPV subtypes in Fuyang area.Methods:The pathological diagnosis in 2 140 HPV detection women were implemented,the HPV subtype was analyzed using the flow-through hybridization and gene-chip.Results:The total infection,single infection and high-risk infection rates of HPV were 28.8%,58.3% and 22.9%,respectively.The most common types of HPV infections were in turn HPV16(21.4%),HPV 58(9.5%),HPV 52(7.3%),HPV 31(6.0%) and HPV 18(5.8%).The difference of the infection rates between high-risk type and each HPV subtype was not statistically significant(P>0.05).Conclusions:HPV16,52 and 58 types are the main infection type of HPV,the distribution of HPV subtype has regional specificity in Fuyang area.
2015, 39(7): 917-919.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.027
Abstract:
Objective:To investigate the application value of vitamin C combined with adenosine cyclophosphate in children with viral myocarditis.Methods:One hundred and thirty children with viral myocarditis were randomly divided into the control group and observation group(65 cases in each group).The control group and observation group were treated with conventional therapy and vitamin C combined with adenosine cyclophosphate based on conventional therapy,respectively.The related index changes between two groups were compared.Results:The effective rate of treatment in observation group was significantly higher than that in control group(PPPPConclusions:The curative effect of vitamin C combined with adenosine cyclophosphate in children with viral myocarditis is exact,which can effectively reduce the inflammatory reaction,resist lipid peroxidation and protect cardiac muscle cell,and is worthy of clinical promotion.
Objective:To investigate the application value of vitamin C combined with adenosine cyclophosphate in children with viral myocarditis.Methods:One hundred and thirty children with viral myocarditis were randomly divided into the control group and observation group(65 cases in each group).The control group and observation group were treated with conventional therapy and vitamin C combined with adenosine cyclophosphate based on conventional therapy,respectively.The related index changes between two groups were compared.Results:The effective rate of treatment in observation group was significantly higher than that in control group(PPPPConclusions:The curative effect of vitamin C combined with adenosine cyclophosphate in children with viral myocarditis is exact,which can effectively reduce the inflammatory reaction,resist lipid peroxidation and protect cardiac muscle cell,and is worthy of clinical promotion.
2015, 39(7): 920-921.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.028
Abstract:
Objective:To compared the effects of hypobaric spinal anesthesia and general anesthesia in elderly patients treated with artificial femoral head replacement.Methods:Thirty-six elderly patients with ASAⅠ to Ⅲ treated with artificial femoral head replacement,without uncontrolled heart failure,pneumonia and atelectasis,were randomly divided into the bupivacaine hypobaric spinal anesthesia group(group A) and general anesthesia group(group B).The amount of bleeding,recovery time of limb function,postoperative pulmonary complications,hospital stay and total hospitalization expense between two groups were compared.Results:The differences of the amount of bleeding and postoperative pulmonary complications between two groups were not significant(P>0.05).The motor function recovery time of lower limb in group A was longer than that in group B(PPConclusions:Hypobaric spinal anesthesia with bupivacaine is more suitable for the elderly patients treated with artificial femoral head replacement,which is a good anesthesia way.
Objective:To compared the effects of hypobaric spinal anesthesia and general anesthesia in elderly patients treated with artificial femoral head replacement.Methods:Thirty-six elderly patients with ASAⅠ to Ⅲ treated with artificial femoral head replacement,without uncontrolled heart failure,pneumonia and atelectasis,were randomly divided into the bupivacaine hypobaric spinal anesthesia group(group A) and general anesthesia group(group B).The amount of bleeding,recovery time of limb function,postoperative pulmonary complications,hospital stay and total hospitalization expense between two groups were compared.Results:The differences of the amount of bleeding and postoperative pulmonary complications between two groups were not significant(P>0.05).The motor function recovery time of lower limb in group A was longer than that in group B(PPConclusions:Hypobaric spinal anesthesia with bupivacaine is more suitable for the elderly patients treated with artificial femoral head replacement,which is a good anesthesia way.
2015, 39(7): 943-946.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.039
Abstract:
Objective:To analyze the characteristics and regularities of the adverse drug reactions(ADR) in county hospitals of Anhui province,for improving the rational use of drug in clinic.Methods:A total of 1 944 cases of ADR reports collected from nine county level hospitals of Anhui province from 2012 to 2013 were statistically classified and analyzed.Results:The main cause of ADR was originated from intravenous administration(73.8%);damaging the skin and its appendages was the main lesion in ADR cases(30.3%);about 38.7% of ADR cases were mainly caused by using antimicrobial drugs;the difference of the drug delivery route,organs or systems involved,type of drugs and the number of reported cases in different hospital has statistical significance(PConclusions:The occurrence of ADR related to the routs of drug delivery and the type of drug,ADR monitoring and reporting system in county hospital execute differently.
Objective:To analyze the characteristics and regularities of the adverse drug reactions(ADR) in county hospitals of Anhui province,for improving the rational use of drug in clinic.Methods:A total of 1 944 cases of ADR reports collected from nine county level hospitals of Anhui province from 2012 to 2013 were statistically classified and analyzed.Results:The main cause of ADR was originated from intravenous administration(73.8%);damaging the skin and its appendages was the main lesion in ADR cases(30.3%);about 38.7% of ADR cases were mainly caused by using antimicrobial drugs;the difference of the drug delivery route,organs or systems involved,type of drugs and the number of reported cases in different hospital has statistical significance(PConclusions:The occurrence of ADR related to the routs of drug delivery and the type of drug,ADR monitoring and reporting system in county hospital execute differently.
2015, 39(7): 946-948.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.040
Abstract:
Objective:To explore the curative effects and clinical safety of azithromycin(AZM) in the treatment of respiratory tract infection in children.Methods:One hundred and forty children(age≤10 years old) with acute bacterial respiratory infection were randomly divided into the observation group and control group(70 cases each group) using random number method.The observation group and control group were treated with AZM and cefuroxime sodium,respectively.The change of the clinical signs before and after treatment,clinical curative effects,clearance of pathogens and clinical safety in two groups were recorded and compared.Results:The disappearance time of fever,cough,short breath and lung sound in observation group were significantly shorter than those of in control group(PP>0.05).The difference of the clearance rate of pathogenic bacteria between the observation group(85.7%) and control group(80.6%) was not statistically significant(P>0.05).The drug susceptibility test results showed that the pathogen sensitive rates of AZM,cefuroxime sodium,erythromycin and penicillin were 90.9%,87.9%,68.2% and 45.5%,respectively.The difference of the pathogen sensitive rates between AZM and cefuroxime sodium was not statistically significant(P>0.05) while their pathogen sensitive rates were higher than those of erythromycin and penicillin(PPConclusions:The treatment of respiratory tract infection in children with azithromycin is good effects,short course,smaller dose and wider antimicrobial spectrum,and which is worthy of clinical promotion.
Objective:To explore the curative effects and clinical safety of azithromycin(AZM) in the treatment of respiratory tract infection in children.Methods:One hundred and forty children(age≤10 years old) with acute bacterial respiratory infection were randomly divided into the observation group and control group(70 cases each group) using random number method.The observation group and control group were treated with AZM and cefuroxime sodium,respectively.The change of the clinical signs before and after treatment,clinical curative effects,clearance of pathogens and clinical safety in two groups were recorded and compared.Results:The disappearance time of fever,cough,short breath and lung sound in observation group were significantly shorter than those of in control group(PP>0.05).The difference of the clearance rate of pathogenic bacteria between the observation group(85.7%) and control group(80.6%) was not statistically significant(P>0.05).The drug susceptibility test results showed that the pathogen sensitive rates of AZM,cefuroxime sodium,erythromycin and penicillin were 90.9%,87.9%,68.2% and 45.5%,respectively.The difference of the pathogen sensitive rates between AZM and cefuroxime sodium was not statistically significant(P>0.05) while their pathogen sensitive rates were higher than those of erythromycin and penicillin(PPConclusions:The treatment of respiratory tract infection in children with azithromycin is good effects,short course,smaller dose and wider antimicrobial spectrum,and which is worthy of clinical promotion.
2015, 39(7): 949-951.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.041
Abstract:
Objective:To observe the changes of serum endothelin-1(ET-1) and brain natriuretic peptide(BNP)levels in heart failure patients and explore the correlations.Methods:One hundred and twenty cases with heart failure were selected as observation group and 80 healthy persons as control group.Serum ET-1 and BNP levels were compared between the two groups.ET-1 and BNP levels in different New York heart association(NYHA) gradation patients were also recorded and their correlation with the degree of heart failure was explored.Results:Serum ET-1 and BNP levels in observation group were much higher than those in control group(PPPPConclusions:Serum ET-1 and BNP levels were greatly increased in heart failure patients,and closely related to disease severity.They can be the predictive indexes for evaluating disease condition and prognosis.
Objective:To observe the changes of serum endothelin-1(ET-1) and brain natriuretic peptide(BNP)levels in heart failure patients and explore the correlations.Methods:One hundred and twenty cases with heart failure were selected as observation group and 80 healthy persons as control group.Serum ET-1 and BNP levels were compared between the two groups.ET-1 and BNP levels in different New York heart association(NYHA) gradation patients were also recorded and their correlation with the degree of heart failure was explored.Results:Serum ET-1 and BNP levels in observation group were much higher than those in control group(PPPPConclusions:Serum ET-1 and BNP levels were greatly increased in heart failure patients,and closely related to disease severity.They can be the predictive indexes for evaluating disease condition and prognosis.
2015, 39(7): 951-952.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.042
Abstract:
Objective:To investigate the distribution of irregular antibodies.Methods:The serums irregular antibodies in 23 940 patients were screened using microcolumn gel antiglobulin test card from April to December 2014,the positive specimens were specifically identified and analyzed.Results:The positive antibodies in 121 cases were detected,the positive rate of which was 0.51%.The proportion of screening in blood type systems of Rh-hr,Kidd,MNSs,Duffy and Lewis were 89.26%,1.65%,6.61%,1.65% and 0.83%,respectively.The positive detection rate in female patients(0.71%) was significantly higher than that in male patients(0.31%)(PConclusions:The irregular antibody in blood transfusion patients must be screened,especially for female patient.The blood type systems should be considered in identifying the irregular antibody at first.
Objective:To investigate the distribution of irregular antibodies.Methods:The serums irregular antibodies in 23 940 patients were screened using microcolumn gel antiglobulin test card from April to December 2014,the positive specimens were specifically identified and analyzed.Results:The positive antibodies in 121 cases were detected,the positive rate of which was 0.51%.The proportion of screening in blood type systems of Rh-hr,Kidd,MNSs,Duffy and Lewis were 89.26%,1.65%,6.61%,1.65% and 0.83%,respectively.The positive detection rate in female patients(0.71%) was significantly higher than that in male patients(0.31%)(PConclusions:The irregular antibody in blood transfusion patients must be screened,especially for female patient.The blood type systems should be considered in identifying the irregular antibody at first.
2015, 39(7): 953-955.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.043
Abstract:
Objective:To investigate the value of second harmonic combined with quantitative analysis of real-time contrast enhanced ultrasound in the differential diagnosis of liver benign and malignant cystic lesions.Methods:Fifty-five patients with liver benign and malignant cystic lesions were detected by the constrast echocardiography,the contrast enhanced mode was analyzed.The enhancement process of contrast agent in lesions was real-time recorded,the angiography quantitative parameters of the lesion was obtained and analyzed by software.The patients were divided into the benign group and malignant group,the time of contrast agent arrival and peak,and the contrast peak intensity between two groups were compared.Results:The second harmonic in 55 patients were the cystic lesions,the hepatic cyst was thin-wall without reinforcement.A few point-shaped reinforcement in the hepatic hydatid disease centre,and liquefaction of hepatic tuberculoma,liver abscess formation,liver metastases of colorectal carcinoma and liquefaction,arterial phase is thick-wall " ring " reinforcement,portal venous phase and delayed phase with low reinforcement and centre without enhancement were observed.The time of contrast agent peak and contrast peak intensity in the benign group were significantly higher than those in malignant group(PConclusions:The second harmonic combined with contrast agent peak time,and contrast peak intensity of ultrasonic contrast can distinguish the benign and malignant lesions.
Objective:To investigate the value of second harmonic combined with quantitative analysis of real-time contrast enhanced ultrasound in the differential diagnosis of liver benign and malignant cystic lesions.Methods:Fifty-five patients with liver benign and malignant cystic lesions were detected by the constrast echocardiography,the contrast enhanced mode was analyzed.The enhancement process of contrast agent in lesions was real-time recorded,the angiography quantitative parameters of the lesion was obtained and analyzed by software.The patients were divided into the benign group and malignant group,the time of contrast agent arrival and peak,and the contrast peak intensity between two groups were compared.Results:The second harmonic in 55 patients were the cystic lesions,the hepatic cyst was thin-wall without reinforcement.A few point-shaped reinforcement in the hepatic hydatid disease centre,and liquefaction of hepatic tuberculoma,liver abscess formation,liver metastases of colorectal carcinoma and liquefaction,arterial phase is thick-wall " ring " reinforcement,portal venous phase and delayed phase with low reinforcement and centre without enhancement were observed.The time of contrast agent peak and contrast peak intensity in the benign group were significantly higher than those in malignant group(PConclusions:The second harmonic combined with contrast agent peak time,and contrast peak intensity of ultrasonic contrast can distinguish the benign and malignant lesions.
2015, 39(7): 961-963.
doi: 10.13898/j.cnki.issn.1000-2200.2015.07.047
Abstract:
Objective:To explore the application effects of the “job advancement” in central sterile supply department.Methods:The recovery,inventory and pretreatment of 32 774 surgical instruments using the traditional mode was served as the control group from January to April 2014,the 69 646 surgical instruments pre-treated with the "job advancement " mode were served as the observation group from May to August 2014.The backwashing rate of instruments and satisfaction degree of clinical department between two groups were compared.Results:The rate of the instrument backwashing decreased 5.45%,and the satisfaction degree increased to 100% when the “job advancement” was employed in central sterile supply department.The differences of the backwashing rate of instruments and satisfaction degree of operation room between two groups were statistically significant(PConclusions:Conclusions:The “job advancement” mode in central sterile supply department can decrease the backwashing rate of instrument,enhance the cleaning quality and satisfaction degree in central sterile supply department,which is conducive to further ensure patients' safety and high quality nursing service.
Objective:To explore the application effects of the “job advancement” in central sterile supply department.Methods:The recovery,inventory and pretreatment of 32 774 surgical instruments using the traditional mode was served as the control group from January to April 2014,the 69 646 surgical instruments pre-treated with the "job advancement " mode were served as the observation group from May to August 2014.The backwashing rate of instruments and satisfaction degree of clinical department between two groups were compared.Results:The rate of the instrument backwashing decreased 5.45%,and the satisfaction degree increased to 100% when the “job advancement” was employed in central sterile supply department.The differences of the backwashing rate of instruments and satisfaction degree of operation room between two groups were statistically significant(PConclusions:Conclusions:The “job advancement” mode in central sterile supply department can decrease the backwashing rate of instrument,enhance the cleaning quality and satisfaction degree in central sterile supply department,which is conducive to further ensure patients' safety and high quality nursing service.
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