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2016 Vol. 41, No. 11
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2016, 41(11): 1401-1404.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.001
Abstract:
Objective: To observe the effects of the co-exposure of lead and cadmium during drinking water from puberty to early adulthood on the hepatic and renal function in male mice.Methods: Sixty healthy male ICR mice with 4 weeks old were randomly divided into the control group,lead group,cadmium group,and lead &cadmium group(15 mice each group).The control group,lead group,cadmium group,and lead & cadmium group were bred using the pure water,lead acetate solution,cadmium chloride solution,and mixture solution of lead acetate with cadmium chloride by oral,respectively.After 40 days of exposure,the blood was collected by removing eyeballs.The weight of liver and kidney were calculated for obtaining the organ coefficient after the mouse was sacrificed.The serum alanine aminotransferase(ALT) and alkaline phosphatase(ALP) activities,and serum creatinine(Cr) and urea nitrogen(BUN) content were detected,the histological morphology of liver and kidney was evaluated using H&E staining.Results: The daily water intake in control group,cadmium group and lead & cadmium group were lower than that in lead group(P<0.05 to P<0.01),and the daily diet intake in lead group and cadmium group were lower than that in control group and cadmium & lead group(P<0.05 to P<0.01),and the differences of body weight between four groups with 4 to 10 weeks old were not statistically significant(P>0.05).After 40 days of exposure,the differences of the body weight,liver weight,liver coefficient,serum ALT and ALP activities,and liver histological morphology in lead group,cadmium group and lead & cadmium group were not identified.The kidney weight in lead & cadmium group was lower than that in cadmium group(P<0.05),but compared with the control group,the differences of the kidney weight,liver histological morphology and serum Cr and BUN content between the control group,and the lead group,cadmium group and lead & cadmium group were not statistically significant(P>0.05). Conclusions: The co-exposure of lead and cadmium during drinking water from puberty to early adulthood can not cause the hepatic and renal function injury.
Objective: To observe the effects of the co-exposure of lead and cadmium during drinking water from puberty to early adulthood on the hepatic and renal function in male mice.Methods: Sixty healthy male ICR mice with 4 weeks old were randomly divided into the control group,lead group,cadmium group,and lead &cadmium group(15 mice each group).The control group,lead group,cadmium group,and lead & cadmium group were bred using the pure water,lead acetate solution,cadmium chloride solution,and mixture solution of lead acetate with cadmium chloride by oral,respectively.After 40 days of exposure,the blood was collected by removing eyeballs.The weight of liver and kidney were calculated for obtaining the organ coefficient after the mouse was sacrificed.The serum alanine aminotransferase(ALT) and alkaline phosphatase(ALP) activities,and serum creatinine(Cr) and urea nitrogen(BUN) content were detected,the histological morphology of liver and kidney was evaluated using H&E staining.Results: The daily water intake in control group,cadmium group and lead & cadmium group were lower than that in lead group(P<0.05 to P<0.01),and the daily diet intake in lead group and cadmium group were lower than that in control group and cadmium & lead group(P<0.05 to P<0.01),and the differences of body weight between four groups with 4 to 10 weeks old were not statistically significant(P>0.05).After 40 days of exposure,the differences of the body weight,liver weight,liver coefficient,serum ALT and ALP activities,and liver histological morphology in lead group,cadmium group and lead & cadmium group were not identified.The kidney weight in lead & cadmium group was lower than that in cadmium group(P<0.05),but compared with the control group,the differences of the kidney weight,liver histological morphology and serum Cr and BUN content between the control group,and the lead group,cadmium group and lead & cadmium group were not statistically significant(P>0.05). Conclusions: The co-exposure of lead and cadmium during drinking water from puberty to early adulthood can not cause the hepatic and renal function injury.
2016, 41(11): 1405-1407,1412.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.002
Abstract:
Objective: To explore the relationship between the loci of thyroid stimulating hormone receptor(TSHR) gene intron 1 single nucleotide polymorphisms(SNPs) and Graves disease(GD) and its clinical manifestations in Han Chinese.Methods: Six hundred and ninety-nine Han Chinese GD patients and 563 health people were selected.The six SNPs site genotypes of TSHR gene intron 1 area on chromosome 14 in all cases were detected using Taqman probe techique,the correlation of which with GD susceptibility was analyzed.Results: The differences of the frequency distributions of rs179247,rs2284722,rs12101261 and rs4903964 sites between GD patients and healthy people were satistically significant(P<0.05).The rs12101261 was the strongest susceptibility loci in the correlation with GD.The rs12101261 was correlation with the serum level of TRAb and gender,and not significant correlation wih the degree of goiter and eye.Conclusions: The TSHR gene intron 1 SNPs is significantly associated with GD.The rs12101261 is the strongest susceptibility loci,which is closely related to the onset of GD in positive thyrotropin receptor antibody patients.
Objective: To explore the relationship between the loci of thyroid stimulating hormone receptor(TSHR) gene intron 1 single nucleotide polymorphisms(SNPs) and Graves disease(GD) and its clinical manifestations in Han Chinese.Methods: Six hundred and ninety-nine Han Chinese GD patients and 563 health people were selected.The six SNPs site genotypes of TSHR gene intron 1 area on chromosome 14 in all cases were detected using Taqman probe techique,the correlation of which with GD susceptibility was analyzed.Results: The differences of the frequency distributions of rs179247,rs2284722,rs12101261 and rs4903964 sites between GD patients and healthy people were satistically significant(P<0.05).The rs12101261 was the strongest susceptibility loci in the correlation with GD.The rs12101261 was correlation with the serum level of TRAb and gender,and not significant correlation wih the degree of goiter and eye.Conclusions: The TSHR gene intron 1 SNPs is significantly associated with GD.The rs12101261 is the strongest susceptibility loci,which is closely related to the onset of GD in positive thyrotropin receptor antibody patients.
2016, 41(11): 1408-1412.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.003
Abstract:
Objective: To compare the therapeutic effects of different extracts from Psoralea corylifolia L and Nutmeg on the visceral hypersensitivity rats with irritable bowel syndrome(IBS).Methods: Forty-eight newborn SD rats were randomly divided into six groups(8 rats each group).Except the normal group,the rest groups were treated with Mother-Child separation combined with acetic acid enema to establish the visceral hypersensitivity rat model.At the beginning of the sixth week after establishing model,all model rats were irrigated using the water double-extract,alcohol extract and water extract from Psoralea corylifolia L and Nutmeg,and positive medicine of pinaverium bromide once a day for 2 weeks,respectively.The pathological changes and visceral hypersensitivity-related indicators were observed in IBS rats.The expressions of CRF and CFRR1 were determined by immunofluorescence technique.Results: The water double-extract,alcohol extract and water extract from Psoralea corylifolia L and Nutmeg could enhance the reflex threshold of abdomen retraction(P<0.05 to P<0.01),and decrease the levels of CRF and RFR1 in colon in visceral hypersensitivity rats.Conclusions: Different extracts from Psoralea corylifolia L and Nutmeg have certain treatment effect on the visceral hypersensitivity rats,and the effect of alcohol extract is the best.
Objective: To compare the therapeutic effects of different extracts from Psoralea corylifolia L and Nutmeg on the visceral hypersensitivity rats with irritable bowel syndrome(IBS).Methods: Forty-eight newborn SD rats were randomly divided into six groups(8 rats each group).Except the normal group,the rest groups were treated with Mother-Child separation combined with acetic acid enema to establish the visceral hypersensitivity rat model.At the beginning of the sixth week after establishing model,all model rats were irrigated using the water double-extract,alcohol extract and water extract from Psoralea corylifolia L and Nutmeg,and positive medicine of pinaverium bromide once a day for 2 weeks,respectively.The pathological changes and visceral hypersensitivity-related indicators were observed in IBS rats.The expressions of CRF and CFRR1 were determined by immunofluorescence technique.Results: The water double-extract,alcohol extract and water extract from Psoralea corylifolia L and Nutmeg could enhance the reflex threshold of abdomen retraction(P<0.05 to P<0.01),and decrease the levels of CRF and RFR1 in colon in visceral hypersensitivity rats.Conclusions: Different extracts from Psoralea corylifolia L and Nutmeg have certain treatment effect on the visceral hypersensitivity rats,and the effect of alcohol extract is the best.
2016, 41(11): 1413-1416,1421.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.004
Abstract:
Objective: To investigate the effects of hydrogen peroxide(H2O2) on the expression of interleukin-37(IL-37) in EA.hy926 cells.Methods: The expressions of IL-37 mRNA and protein in different time-points of human umbilical vein endothelial cell treated with different concentration of H2O2 were detected by qRT-PCR and Western blot.Results: The results of qPCR showed that the levels of IL-37 mRNA in human umbilical vein endothelial cell treated with different concentration of H2O2 significantly increased,which was the concentration-dependent(P<0.01).The results of Western blot showed that the level of IL-37 protein in human umbilical vein endothelial cell treated with H2O2 for 20 h was significantly higher than that in control group(P<0.01).Conclusions: The expression of IL-37 in human umbilical vein endothelial cell can be up-regulated by H2O2,which may be helpful to study the role of IL-37 in cellular oxidative stress.
Objective: To investigate the effects of hydrogen peroxide(H2O2) on the expression of interleukin-37(IL-37) in EA.hy926 cells.Methods: The expressions of IL-37 mRNA and protein in different time-points of human umbilical vein endothelial cell treated with different concentration of H2O2 were detected by qRT-PCR and Western blot.Results: The results of qPCR showed that the levels of IL-37 mRNA in human umbilical vein endothelial cell treated with different concentration of H2O2 significantly increased,which was the concentration-dependent(P<0.01).The results of Western blot showed that the level of IL-37 protein in human umbilical vein endothelial cell treated with H2O2 for 20 h was significantly higher than that in control group(P<0.01).Conclusions: The expression of IL-37 in human umbilical vein endothelial cell can be up-regulated by H2O2,which may be helpful to study the role of IL-37 in cellular oxidative stress.
2016, 41(11): 1417-1421.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.005
Abstract:
Objective: To construct and package the recombination lentiviral vector containing the interfering RNA gene targeting against human AURKA gene,and preliminary investigate the AURKA gene function.Methods: The recombination pGCLV-GFP lentiviral vector plasmid containing the interfering RNA gene targeting against human AURKA gene was transfected into the 293T cells,then which was packaged.The viral supernatant was collected to transfect A549 cells.The transfection efficiency was determined by detecting the GFP expression under the fluorescent microscopy.The expression level of AURKA protein was examined by Western blot for identifying the inhibitory efficiency of RNAi.The effect of AURKA silencd by RNAi on the proliferation of A549 cell was analyzed by BrdU assay.Colony formation assay was used to explore the sensitivity of the transfected cells to Vincristine.Results: The recombination lentiviral vector containing the interfering RNA gene targeting against human AURKA gene was successfully constructed,and the sequence and insert site of the interference segment were confirmed by PCR and DNA sequencing.The lentivirus was packaged in 293T cells,and the high titer virus supernatant was obtained.The transfection efficiency of small hairpin RNA(shRNA) targeting AURKA into A459 cells was 100%.The result of Western blot showed that the LV-AURKA could significantly inhibit the expression of AURKA protein,the result of BrdU showed down-regulating of AURKA gene could inhibit the proliferation of A549 cells,and the colony formation assay showed that the expression of AURKA gene could enhance the sensitivity of A549 cells to vincristine.Conclusions: The interfering RNA gene targeting against human AURKA mediated by lentiviral vector can effectively inhibit the AURKA gene expression,decreases the proliferation ability of A549 cells,and enhance the sensitivity of A549 cells to vincristine.
Objective: To construct and package the recombination lentiviral vector containing the interfering RNA gene targeting against human AURKA gene,and preliminary investigate the AURKA gene function.Methods: The recombination pGCLV-GFP lentiviral vector plasmid containing the interfering RNA gene targeting against human AURKA gene was transfected into the 293T cells,then which was packaged.The viral supernatant was collected to transfect A549 cells.The transfection efficiency was determined by detecting the GFP expression under the fluorescent microscopy.The expression level of AURKA protein was examined by Western blot for identifying the inhibitory efficiency of RNAi.The effect of AURKA silencd by RNAi on the proliferation of A549 cell was analyzed by BrdU assay.Colony formation assay was used to explore the sensitivity of the transfected cells to Vincristine.Results: The recombination lentiviral vector containing the interfering RNA gene targeting against human AURKA gene was successfully constructed,and the sequence and insert site of the interference segment were confirmed by PCR and DNA sequencing.The lentivirus was packaged in 293T cells,and the high titer virus supernatant was obtained.The transfection efficiency of small hairpin RNA(shRNA) targeting AURKA into A459 cells was 100%.The result of Western blot showed that the LV-AURKA could significantly inhibit the expression of AURKA protein,the result of BrdU showed down-regulating of AURKA gene could inhibit the proliferation of A549 cells,and the colony formation assay showed that the expression of AURKA gene could enhance the sensitivity of A549 cells to vincristine.Conclusions: The interfering RNA gene targeting against human AURKA mediated by lentiviral vector can effectively inhibit the AURKA gene expression,decreases the proliferation ability of A549 cells,and enhance the sensitivity of A549 cells to vincristine.
2016, 41(11): 1422-1426,1430.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.006
Abstract:
Objective: To investigate the value of the detection of epidermal growth factor receptor(EGFR) gene mutation in pleural effusion of patients with advanced non-small cell lung cell(NSCLC) in predicting the curative effect of Erlotinib.Methods: The EGFR gene mutation in pleural effusion of 275 patients with NSCLC were detected using PCR-HRM,and 52 tissue samples were detected using HRM and direct sequencing.The consistency and repeatability of EGFR mutation in pleural effusion and tissue specimens were compared,respectively.The EGFR mutation sensitive patients were randomly treated with the erlotinib or gemcitabine cisplatin therapy.The objective response rate(ORR) and median progression-free survival(mPFS) between two groups were compared.Results: The sensitive mutation rate of EGFR in pleural effusion of 275 NSCLC patients was 55.3%.Among the pairing tissue specimens and pleural effusion of 52 cases,the sensitive mutation rate of EGFR was 61.5%,which was higher than that using the direct sequencing(40.3%)(P<0.01).The sensitive mutation rate of EGFR in pleural effusion was 55.8%,which was higher than that using direct sequencing(36.5%)(P<0.01).The coincidence rate of the EGFR mutation in tissue specimen and pleural effusion was 82.6%.The mPFS in Erlotinib group was 11.5 months(95%CI for 10.4 to 12.6),which was higher than 4.4 months in GP group(95%CI for 3.9 to 4.8)(P<0.01).The ORR in Erlotinib group(70.0%) was significantly higher than that in GP group(29.4%)(P<0.01).Conclusions: Among the patients with advance NSCLC,the sensitive mutation detection of EGFR in pleural effusion can compensate or replace the detection of tissue specimens,and the sensibility of HRM is better than that of direct sequencing.The application of Erlotinib in NSCLC patients with EGFR sensitive mutation can improve the ORR,and prolong mPFS.
Objective: To investigate the value of the detection of epidermal growth factor receptor(EGFR) gene mutation in pleural effusion of patients with advanced non-small cell lung cell(NSCLC) in predicting the curative effect of Erlotinib.Methods: The EGFR gene mutation in pleural effusion of 275 patients with NSCLC were detected using PCR-HRM,and 52 tissue samples were detected using HRM and direct sequencing.The consistency and repeatability of EGFR mutation in pleural effusion and tissue specimens were compared,respectively.The EGFR mutation sensitive patients were randomly treated with the erlotinib or gemcitabine cisplatin therapy.The objective response rate(ORR) and median progression-free survival(mPFS) between two groups were compared.Results: The sensitive mutation rate of EGFR in pleural effusion of 275 NSCLC patients was 55.3%.Among the pairing tissue specimens and pleural effusion of 52 cases,the sensitive mutation rate of EGFR was 61.5%,which was higher than that using the direct sequencing(40.3%)(P<0.01).The sensitive mutation rate of EGFR in pleural effusion was 55.8%,which was higher than that using direct sequencing(36.5%)(P<0.01).The coincidence rate of the EGFR mutation in tissue specimen and pleural effusion was 82.6%.The mPFS in Erlotinib group was 11.5 months(95%CI for 10.4 to 12.6),which was higher than 4.4 months in GP group(95%CI for 3.9 to 4.8)(P<0.01).The ORR in Erlotinib group(70.0%) was significantly higher than that in GP group(29.4%)(P<0.01).Conclusions: Among the patients with advance NSCLC,the sensitive mutation detection of EGFR in pleural effusion can compensate or replace the detection of tissue specimens,and the sensibility of HRM is better than that of direct sequencing.The application of Erlotinib in NSCLC patients with EGFR sensitive mutation can improve the ORR,and prolong mPFS.
2016, 41(11): 1427-1430.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.007
Abstract:
Objective: To investigate the correlation of the levels of plasma enzyme chitin 40(YKL-40) and endothelial microparticle(EMP) with the acute coronary syndrome(ACS) in elder patients.Methods: A total of 180 patients(≥65 years old) with coronary angiography were randomly divided into the ACS group(96 cases) and control group(84 cases).The serum levels of plasma YKL-40 and EMP in two groups were measured by Enzyme-linked immunosorbent assays and cytometric bead assay technique labeled by CD31+/CD42b-EMPs,respectively.The vascular stenosis degree was quantified by Gensini score.Results: The levels of the YKL-40 and CD31+/CD42b-EMPs in ACS group were significantly higher than those in control group(P<0.01).The Gensini score was significantly positive correlation with the levels of YKL-40 and CD31+/CD42b-EMPs in ACS group(r=0.522,P<0.01;r=0.561,P<0.01).The level of YKL-40 was significantly positive correlation with the level of CD31+/CD42b-EMPs in ACS group(r=0.625,P<0.01).Conclusions: The levels of plasma YKL-40 and CD31+/CD42b-EMPs in ACS patients increase significantly,which is related to the vascular lesion degree.The YKL-40 and EMP maybe a new biochemical marker in diagnosing ACS,which can provide a reference in identifying the severity and risk stratification of coronary artery lesions.
Objective: To investigate the correlation of the levels of plasma enzyme chitin 40(YKL-40) and endothelial microparticle(EMP) with the acute coronary syndrome(ACS) in elder patients.Methods: A total of 180 patients(≥65 years old) with coronary angiography were randomly divided into the ACS group(96 cases) and control group(84 cases).The serum levels of plasma YKL-40 and EMP in two groups were measured by Enzyme-linked immunosorbent assays and cytometric bead assay technique labeled by CD31+/CD42b-EMPs,respectively.The vascular stenosis degree was quantified by Gensini score.Results: The levels of the YKL-40 and CD31+/CD42b-EMPs in ACS group were significantly higher than those in control group(P<0.01).The Gensini score was significantly positive correlation with the levels of YKL-40 and CD31+/CD42b-EMPs in ACS group(r=0.522,P<0.01;r=0.561,P<0.01).The level of YKL-40 was significantly positive correlation with the level of CD31+/CD42b-EMPs in ACS group(r=0.625,P<0.01).Conclusions: The levels of plasma YKL-40 and CD31+/CD42b-EMPs in ACS patients increase significantly,which is related to the vascular lesion degree.The YKL-40 and EMP maybe a new biochemical marker in diagnosing ACS,which can provide a reference in identifying the severity and risk stratification of coronary artery lesions.
2016, 41(11): 1431-1435.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.008
Abstract:
Objective: To observe the effects of pre-injection of parecoxib sodium on emergence agitation in children with sevoflurane anesthesia.Methods: One hundred and twenty children scheduled by cheft palate repair treated with sevoflurance anesthesia were randomly divided into the low dose parecoxib sodium(L group),medium dose parecoxib sodium(M group),high dose parecoxib sodium(H group) and control group(C group)(30 cases each group).Before induction of anaesthesia,the L,M,H and C group were intravenously injected using 0.5mg/kg parecoxib,0.75mg/kg parecoxib,1mg/kg parecoxib and 0.9% normal saline,respectively.All cases were induced with oxygen mask(6 L/min) combined with 8% sevoflurance,and then were treated with 0.05mg/kg midazolam,0.1mg/kg vecuronium and 3μg/kg fentanyl by intravenous injection.The patients were endotracheally intubated and maintained anaesthesia using 2% to 3% until the end of operation.The operation condition,emergence agitation,pain,sedation and adverse reaction after 24 h of operation were recorded.Results: The differences of the anesthesia time,operation time,extubation time and PACU stay time between four groups were not statistically significant(P>0.05).The incidences of the agitation in M group and H group were lower than that in C group(P<0.05).The PAED scores in L,M and H groups after anesthesia were significantly lower than that in C group(P<0.01),whose in M and H groups were lower than that in L group(P<0.05),and the differences of the incidences of the agitation and PAED scores between M and H group were not statistically significant(P>0.05).Compared with the FLACC and Ramsay scores in C group,whose in L,M and H group decreased and increased significantly,respectively(P<0.05 to P<0.01).Compared with the L group,the FLACC scores in M and H groups at T0 and T1 decreased(P<0.05 to P<0.01),and the Ramsay scores in M and H groups at T1 and H group at T2 increased(P<0.05 to P<0.01).The differences of between the FLACC scores at each point and Ramsay scores at T0 and T1 in H group,and M group were not statistically significant(P>0.05),but the Ramsay score in H group at T2 was significantly higher than that in M group(P<0.01).The differences of headache,dizziness and respiratory depression between four groups were not statistically significant(P>0.05).Conclusions: The pre-injection of parecoxib sodium can effectively prevent the occurrence of emergence agitation and obvious adverse reaction in children with sevoflurane anesthesia.The pre-injection of 0.75mg/kg parecoxib sodium in preventing the emergence agitation in children.
Objective: To observe the effects of pre-injection of parecoxib sodium on emergence agitation in children with sevoflurane anesthesia.Methods: One hundred and twenty children scheduled by cheft palate repair treated with sevoflurance anesthesia were randomly divided into the low dose parecoxib sodium(L group),medium dose parecoxib sodium(M group),high dose parecoxib sodium(H group) and control group(C group)(30 cases each group).Before induction of anaesthesia,the L,M,H and C group were intravenously injected using 0.5mg/kg parecoxib,0.75mg/kg parecoxib,1mg/kg parecoxib and 0.9% normal saline,respectively.All cases were induced with oxygen mask(6 L/min) combined with 8% sevoflurance,and then were treated with 0.05mg/kg midazolam,0.1mg/kg vecuronium and 3μg/kg fentanyl by intravenous injection.The patients were endotracheally intubated and maintained anaesthesia using 2% to 3% until the end of operation.The operation condition,emergence agitation,pain,sedation and adverse reaction after 24 h of operation were recorded.Results: The differences of the anesthesia time,operation time,extubation time and PACU stay time between four groups were not statistically significant(P>0.05).The incidences of the agitation in M group and H group were lower than that in C group(P<0.05).The PAED scores in L,M and H groups after anesthesia were significantly lower than that in C group(P<0.01),whose in M and H groups were lower than that in L group(P<0.05),and the differences of the incidences of the agitation and PAED scores between M and H group were not statistically significant(P>0.05).Compared with the FLACC and Ramsay scores in C group,whose in L,M and H group decreased and increased significantly,respectively(P<0.05 to P<0.01).Compared with the L group,the FLACC scores in M and H groups at T0 and T1 decreased(P<0.05 to P<0.01),and the Ramsay scores in M and H groups at T1 and H group at T2 increased(P<0.05 to P<0.01).The differences of between the FLACC scores at each point and Ramsay scores at T0 and T1 in H group,and M group were not statistically significant(P>0.05),but the Ramsay score in H group at T2 was significantly higher than that in M group(P<0.01).The differences of headache,dizziness and respiratory depression between four groups were not statistically significant(P>0.05).Conclusions: The pre-injection of parecoxib sodium can effectively prevent the occurrence of emergence agitation and obvious adverse reaction in children with sevoflurane anesthesia.The pre-injection of 0.75mg/kg parecoxib sodium in preventing the emergence agitation in children.
2016, 41(11): 1435-1439.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.009
Abstract:
Objective: To investigate the expression of breast cancer resistance protein(BCRP) in invasive breast cancer,and its correlation with the epithelial-mesenchymal transition-related protein.Methods: The expressions of BCRP in 80 invasive breast cancer tissue specimens,40 peritumoral tissue specimens and 40 breast fibroadenoma tissue specimens were detected using immunohistochemistry.The relationship between the expression of BCRP and clinical pathological parameters was analyzed,and the correlations of the expression of BCRP with E-cadhein and N-cadhein were investigated.Results: The positive expression rate of BCRP in invasive breast cancer tissue was 57.5%.The differences of the positive expression rate of BCRP in different histological grade,lymph node metastasis and TNM staging were not statistically significant(P<0.05 to P< 0.01).The expression rate of BCRP were positively and negatively with the expressions of HER-2 and N-cadherin,and E-cadherin,respectively(P<0.01).Conclusions: The BCRP may be involved in the occurrence and development in invasive breast cancer,and which is correlation with EMT.
Objective: To investigate the expression of breast cancer resistance protein(BCRP) in invasive breast cancer,and its correlation with the epithelial-mesenchymal transition-related protein.Methods: The expressions of BCRP in 80 invasive breast cancer tissue specimens,40 peritumoral tissue specimens and 40 breast fibroadenoma tissue specimens were detected using immunohistochemistry.The relationship between the expression of BCRP and clinical pathological parameters was analyzed,and the correlations of the expression of BCRP with E-cadhein and N-cadhein were investigated.Results: The positive expression rate of BCRP in invasive breast cancer tissue was 57.5%.The differences of the positive expression rate of BCRP in different histological grade,lymph node metastasis and TNM staging were not statistically significant(P<0.05 to P< 0.01).The expression rate of BCRP were positively and negatively with the expressions of HER-2 and N-cadherin,and E-cadherin,respectively(P<0.01).Conclusions: The BCRP may be involved in the occurrence and development in invasive breast cancer,and which is correlation with EMT.
2016, 41(11): 1440-1442,1445.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.010
Abstract:
Objective: To investigate the correlation of Muller classification and prognosis of the proximal humerus fractures in young people.Methods: Among 180 proximal humerus fractures patients,the A1 fracture in 20 cases,A2 fracture in 40 cases,A3 fracture in 80 cases and B fracture of 40 cases were identified accorded to Muller classification.All patients were treated with small incision minimally invasive surgical fixation.Results: All fractures were primary healing.The fracture healing time in A1 and A2 fracture patients were significantly shorter than that in other patients(P<0.05).The excellent and good rates of shoulder function in A1,A2,A3 and B fractures patients were 90.0%,80.0%,75.0% and 62.5% after 3 months of operation,respectively,the difference of which in each group was not statistically significant(P>0.05).After 3 months of operation,the differences of the incidences of the vascular injury,infection,bleeding and plate break between four type fractures were not statistically significant(P>0.05).The differences of the pain,daily life,range of motion and strength scores in different Muller classification patients were statistically significant(P<0.05 to P<0.01).Conclusions: The operation healing rate of proximal humerus fracture in young people is high.The application of Muller classification can effectively guide the operation,and judge the prognosis in short-term.With the increasing with the Muller classification,the prognosis of patient is getting better.
Objective: To investigate the correlation of Muller classification and prognosis of the proximal humerus fractures in young people.Methods: Among 180 proximal humerus fractures patients,the A1 fracture in 20 cases,A2 fracture in 40 cases,A3 fracture in 80 cases and B fracture of 40 cases were identified accorded to Muller classification.All patients were treated with small incision minimally invasive surgical fixation.Results: All fractures were primary healing.The fracture healing time in A1 and A2 fracture patients were significantly shorter than that in other patients(P<0.05).The excellent and good rates of shoulder function in A1,A2,A3 and B fractures patients were 90.0%,80.0%,75.0% and 62.5% after 3 months of operation,respectively,the difference of which in each group was not statistically significant(P>0.05).After 3 months of operation,the differences of the incidences of the vascular injury,infection,bleeding and plate break between four type fractures were not statistically significant(P>0.05).The differences of the pain,daily life,range of motion and strength scores in different Muller classification patients were statistically significant(P<0.05 to P<0.01).Conclusions: The operation healing rate of proximal humerus fracture in young people is high.The application of Muller classification can effectively guide the operation,and judge the prognosis in short-term.With the increasing with the Muller classification,the prognosis of patient is getting better.
2016, 41(11): 1443-1445.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.011
Abstract:
Objective: To explore the protective effects of trimetazidine on myocardial injury in patients with sepsis.Methods: Thirty-two sepsis patients with myocardial injury were divided into the treatment group and control group according to the method of random number table(16 cases each group).The control group were treated with conventional therapy,and the treatment group were additionally treated with trimetazidine based on the conventional therapy,20 mg per time,oral or nasal feeding,3 times per day for 7 days.The myocardial necrosis index,brain natriuretic peptide and severity of disease were observed before treatment and after 8 days of treatment.The scores of acute physiology and chronic health evaluation Ⅱ score(APACHE Ⅱ)were calculated before treatment and after 8 days of treatment.Results: After 8 days of treatment,the differences of the levels of cTnI and brain natriuretic peptide,and APACHE Ⅱ score between two groups were statistically significant(P<0.01),and the difference of the level of CK-MB between two groups were not statistically significant(P>0.05).Conclusions: Trimetazidine can improve the myocardial injury in patients with sepsis,which is beneficial to the cardiac function and disease.
Objective: To explore the protective effects of trimetazidine on myocardial injury in patients with sepsis.Methods: Thirty-two sepsis patients with myocardial injury were divided into the treatment group and control group according to the method of random number table(16 cases each group).The control group were treated with conventional therapy,and the treatment group were additionally treated with trimetazidine based on the conventional therapy,20 mg per time,oral or nasal feeding,3 times per day for 7 days.The myocardial necrosis index,brain natriuretic peptide and severity of disease were observed before treatment and after 8 days of treatment.The scores of acute physiology and chronic health evaluation Ⅱ score(APACHE Ⅱ)were calculated before treatment and after 8 days of treatment.Results: After 8 days of treatment,the differences of the levels of cTnI and brain natriuretic peptide,and APACHE Ⅱ score between two groups were statistically significant(P<0.01),and the difference of the level of CK-MB between two groups were not statistically significant(P>0.05).Conclusions: Trimetazidine can improve the myocardial injury in patients with sepsis,which is beneficial to the cardiac function and disease.
2016, 41(11): 1446-1449.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.012
Abstract:
Objective: To investigate the clinical effects of proximal femoral nail anti-rotation(PFNA) in the treatment of type Seinsheimer Ⅴ subtrochanteric fractures.Methods: The clinical data of 89 patients with type Seinsheimer Ⅴ subtrochanteric fracture were retrospectively analyzed.The patients were divided into the observation group(48 cases) and control group(41 cases) according to the technique of internal fixation.The observation group and control group were treated with PFNA and Gamma nail,respectively.The operation time,intraoperative blood loss,perioperative blood loss,time of off-bed after operation,postoperative Harris hip score and postoperative complications between two groups were compared.Results: The patients were followed up for 10 to 18 months,the fractures arrived at the standard of clinical healing.The difference of Harris hip score before operation between the observation group and control group was not statistically significant(P>0.05),and the Harris hip score after operation in observation group was significantly higher than that in control group(P<0.01).The operation time,intraoperative blood loss,perioperative blood loss and time of off-bed after operation in observation group were significantly less than those in control group(P<0.01).The differences of the incidence of four kinds of complications between the observation group and control group were not statistically significant(P>0.05).Conclusions: PFNA is suit for treating the unstable type Seinsheimer V substrochanteric fractures,which is the ideal internal fixation material,and worthy of application in clinic.
Objective: To investigate the clinical effects of proximal femoral nail anti-rotation(PFNA) in the treatment of type Seinsheimer Ⅴ subtrochanteric fractures.Methods: The clinical data of 89 patients with type Seinsheimer Ⅴ subtrochanteric fracture were retrospectively analyzed.The patients were divided into the observation group(48 cases) and control group(41 cases) according to the technique of internal fixation.The observation group and control group were treated with PFNA and Gamma nail,respectively.The operation time,intraoperative blood loss,perioperative blood loss,time of off-bed after operation,postoperative Harris hip score and postoperative complications between two groups were compared.Results: The patients were followed up for 10 to 18 months,the fractures arrived at the standard of clinical healing.The difference of Harris hip score before operation between the observation group and control group was not statistically significant(P>0.05),and the Harris hip score after operation in observation group was significantly higher than that in control group(P<0.01).The operation time,intraoperative blood loss,perioperative blood loss and time of off-bed after operation in observation group were significantly less than those in control group(P<0.01).The differences of the incidence of four kinds of complications between the observation group and control group were not statistically significant(P>0.05).Conclusions: PFNA is suit for treating the unstable type Seinsheimer V substrochanteric fractures,which is the ideal internal fixation material,and worthy of application in clinic.
2016, 41(11): 1449-1451.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.013
Abstract:
Objective: To evaluate the short-term effects and adverse reactions between synchronization chemoradiotherapy and sequential chemoradiotherapy in the treatment of stage Ⅲ non-small cell lung cancer(NSCLC).Methods: Seventy-two patients with stage Ⅲ NSCLC were randomly divided into the synchronization chemoradiotherapy group and sequential chemoradiotherapy group(36 cases each group).The synchronization chemoradiotherapy group were treated with the intensity-modulated radiotherapy combined with docetaxel and cisplatin(DP) chemotherapy for 2 cycles,then chemotherapy for 2 cycles.The sequential chemoradiotherapy group were treated with DP chemotherapy for 2 cycles,then intensity-modulated radiotherapy,and DP chemotherapy for 2 cycles at last.Results: The effective rates of treatment in the synchronization chemoradiotherapy group and sequential chemoradiotherapy group were 75.0% and 38.9%,respectively,the difference of which was statistically significant(P<0.05).The main adverse reactions in two groups included myelosuppression,radiation pneumonia,radiation esophagitis and gastrointestinal reaction.The difference of the incidence of side effect in grade Ⅲ to Ⅳ patients between synchronization chemoradiotherapy group and sequential chemoradiotherapy group was not statistically significant(P>0.05).Conclusions: The treatment effect of patients with grade Ⅲnon-small cell lung cancer with synchronization chemoradiotherapy is better than that with sequential chemoradiotherapy,and the adverse reaction can be tolerated in synchronization chemoradiotherapy group,which is worthy of further study and application.
Objective: To evaluate the short-term effects and adverse reactions between synchronization chemoradiotherapy and sequential chemoradiotherapy in the treatment of stage Ⅲ non-small cell lung cancer(NSCLC).Methods: Seventy-two patients with stage Ⅲ NSCLC were randomly divided into the synchronization chemoradiotherapy group and sequential chemoradiotherapy group(36 cases each group).The synchronization chemoradiotherapy group were treated with the intensity-modulated radiotherapy combined with docetaxel and cisplatin(DP) chemotherapy for 2 cycles,then chemotherapy for 2 cycles.The sequential chemoradiotherapy group were treated with DP chemotherapy for 2 cycles,then intensity-modulated radiotherapy,and DP chemotherapy for 2 cycles at last.Results: The effective rates of treatment in the synchronization chemoradiotherapy group and sequential chemoradiotherapy group were 75.0% and 38.9%,respectively,the difference of which was statistically significant(P<0.05).The main adverse reactions in two groups included myelosuppression,radiation pneumonia,radiation esophagitis and gastrointestinal reaction.The difference of the incidence of side effect in grade Ⅲ to Ⅳ patients between synchronization chemoradiotherapy group and sequential chemoradiotherapy group was not statistically significant(P>0.05).Conclusions: The treatment effect of patients with grade Ⅲnon-small cell lung cancer with synchronization chemoradiotherapy is better than that with sequential chemoradiotherapy,and the adverse reaction can be tolerated in synchronization chemoradiotherapy group,which is worthy of further study and application.
2016, 41(11): 1452-1454.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.014
Abstract:
Objective: To explore the number change of the peripheral blood T lymphocyte subsets(including CD3+,CD3+CD4+ and CD3+CD8+) and its clinical significance in advanced malignant tumor patients before and after chemotherapy.Methods: The standard chemotherapy in 50 advanced malignant tumor patients were implemented according to the disease kind and clinical stage.The peripheral blood was collected before chemotherapy and after 2 cycles of chemotherapy.The number and ratio of T lymph node cell subsets were detected using flow cytometry,the relationship between the level change of T lymph node cell subsets was analyzed.Results: The number of CD3+and CD3+CD4+ T lymphocyte after 2 cycles of chemotherapy were significantly lower than that before chemotherapy in advanced malignant tumor patients(P<0.01).The number of CD3+CD8+ T lymphocyte after 2 cycles of chemotherapy were higher than that before chemotherapy(P<0.01).The ratio of CD3+CD4+ to CD3+CD8+ cells after 2 cycles of chemotherapy decreased significantly(P<0.01).Conclusions: Monitoring the number of peripheral blood T lymphocyte subsets in advanced malignant tumor patients can assess the immune function,guide treatment and predict prognosis.
Objective: To explore the number change of the peripheral blood T lymphocyte subsets(including CD3+,CD3+CD4+ and CD3+CD8+) and its clinical significance in advanced malignant tumor patients before and after chemotherapy.Methods: The standard chemotherapy in 50 advanced malignant tumor patients were implemented according to the disease kind and clinical stage.The peripheral blood was collected before chemotherapy and after 2 cycles of chemotherapy.The number and ratio of T lymph node cell subsets were detected using flow cytometry,the relationship between the level change of T lymph node cell subsets was analyzed.Results: The number of CD3+and CD3+CD4+ T lymphocyte after 2 cycles of chemotherapy were significantly lower than that before chemotherapy in advanced malignant tumor patients(P<0.01).The number of CD3+CD8+ T lymphocyte after 2 cycles of chemotherapy were higher than that before chemotherapy(P<0.01).The ratio of CD3+CD4+ to CD3+CD8+ cells after 2 cycles of chemotherapy decreased significantly(P<0.01).Conclusions: Monitoring the number of peripheral blood T lymphocyte subsets in advanced malignant tumor patients can assess the immune function,guide treatment and predict prognosis.
2016, 41(11): 1455-1456,1459.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.015
Abstract:
Objective: To explore the causes,the treatment of long-term complications with the permanent cardiac pacemaker implantation.Methods: The records of 280 patienrs with pacemakers implantation were reviewed,long-term pacemaker complications of the patients were analyzed.Results: There were 17 patients(6.07%) who developed the long-term pacemaker complications.13 cases(6.34%) over 60 years old,4 cases(5.33%) under 60 years old,there was no statistical difference in the overall rate of complications between patients aged above 60 years old(P>0.05);6 cases(2.14%) of vein thrombosis,4 cases(1.43%) of pacemaker lead thrombosis.3 cases(1.07%) of electrode dislocation,2 cases(0.71%) of pocker ulcerated and infection,1 cases(0.36%) of pacemaker syndrome and 1 cases(0.36%) of pacemaker threshold increased significantly to a pacemaker bad.Conclusions: There is an increasing trend in the rate of vein thrombosis,electrode dislocation,pocker ulcerated and infection.Should attach importance to the pacemaker implantation preparation,intraoperative emphasizes the specification of aseptic operation,strengthening postoperative follow-up,as well as the early discovery and treatment of complications could reduce the risk of complications so as to avoid the serious consequences.
Objective: To explore the causes,the treatment of long-term complications with the permanent cardiac pacemaker implantation.Methods: The records of 280 patienrs with pacemakers implantation were reviewed,long-term pacemaker complications of the patients were analyzed.Results: There were 17 patients(6.07%) who developed the long-term pacemaker complications.13 cases(6.34%) over 60 years old,4 cases(5.33%) under 60 years old,there was no statistical difference in the overall rate of complications between patients aged above 60 years old(P>0.05);6 cases(2.14%) of vein thrombosis,4 cases(1.43%) of pacemaker lead thrombosis.3 cases(1.07%) of electrode dislocation,2 cases(0.71%) of pocker ulcerated and infection,1 cases(0.36%) of pacemaker syndrome and 1 cases(0.36%) of pacemaker threshold increased significantly to a pacemaker bad.Conclusions: There is an increasing trend in the rate of vein thrombosis,electrode dislocation,pocker ulcerated and infection.Should attach importance to the pacemaker implantation preparation,intraoperative emphasizes the specification of aseptic operation,strengthening postoperative follow-up,as well as the early discovery and treatment of complications could reduce the risk of complications so as to avoid the serious consequences.
2016, 41(11): 1457-1459.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.016
Abstract:
Objective: To investigate the risk factors of the recurrent intracerebral hemorrhage.Methods: The data of the age,gender,hypertension,hyperlipidemia,diabetes and imaging in 260 patients with cerebral hemorrhage were investigated.The general condition,risk factors,the first cerebral hemorrhage age and time,recurrence interval time,amount and location of bleeding,and pathogenesis of patients were recorded.The disease condition and state of consciousness of patients at admission were evaluated using GCS scare.Results: Among 260 cases,the rebleeding occurred in 62 cases(23.8%),the location and interval time of which were in basal ganglia(62.9%) and 3 days to 118 months,respectively.The recurrence rate of cerebral hemorrhage was 44% when the diastolic blood pressure was more than 95 mmHg.When the diastolic blood pressure was less than the critical value,the recurrence rate of cerebral hemorrhage was 20%,and the difference of which was not statistically significant(P<0.01).Conclusions: The better the diastolic blood pressure controls,the lower the risk of the recurrence of cerebral hemorrhage is.
Objective: To investigate the risk factors of the recurrent intracerebral hemorrhage.Methods: The data of the age,gender,hypertension,hyperlipidemia,diabetes and imaging in 260 patients with cerebral hemorrhage were investigated.The general condition,risk factors,the first cerebral hemorrhage age and time,recurrence interval time,amount and location of bleeding,and pathogenesis of patients were recorded.The disease condition and state of consciousness of patients at admission were evaluated using GCS scare.Results: Among 260 cases,the rebleeding occurred in 62 cases(23.8%),the location and interval time of which were in basal ganglia(62.9%) and 3 days to 118 months,respectively.The recurrence rate of cerebral hemorrhage was 44% when the diastolic blood pressure was more than 95 mmHg.When the diastolic blood pressure was less than the critical value,the recurrence rate of cerebral hemorrhage was 20%,and the difference of which was not statistically significant(P<0.01).Conclusions: The better the diastolic blood pressure controls,the lower the risk of the recurrence of cerebral hemorrhage is.
2016, 41(11): 1460-1461,1464.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.017
Abstract:
Objective: To investigate the hypoglycemic effects of liraglutide on obesity and normal weight patients with type 2 diabetes.Methods: Ninty patients with type 2 diabetes were divided into the obesity group(39 cases) and normal weight group(normal group,51 cases) according to the body mass index.Two groups were treated with liraglutide.The body mass change and glycemic control effect between two groups were compared after 3 months of treatment.Results: Compared before treatment,the body weight,body mass index,fasting blood glucose,postprandial 2 h blood glucose,C peptide and HbA1c in two groups were significantly improved after 3 months of treatment(P<0.01),and the improvement of all indicators in obese group were significantly better than those in normal group(P<0.01).Conclusions: The curative effect of liraglutide in obese group is more significant than that in normal group.The liraglutide can effectively control the blood glucose,and reduce body weight which is worthy of clinical use.
Objective: To investigate the hypoglycemic effects of liraglutide on obesity and normal weight patients with type 2 diabetes.Methods: Ninty patients with type 2 diabetes were divided into the obesity group(39 cases) and normal weight group(normal group,51 cases) according to the body mass index.Two groups were treated with liraglutide.The body mass change and glycemic control effect between two groups were compared after 3 months of treatment.Results: Compared before treatment,the body weight,body mass index,fasting blood glucose,postprandial 2 h blood glucose,C peptide and HbA1c in two groups were significantly improved after 3 months of treatment(P<0.01),and the improvement of all indicators in obese group were significantly better than those in normal group(P<0.01).Conclusions: The curative effect of liraglutide in obese group is more significant than that in normal group.The liraglutide can effectively control the blood glucose,and reduce body weight which is worthy of clinical use.
2016, 41(11): 1462-1464.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.018
Abstract:
Objective: To investigate the effects of the level of plasma homocysteine(Hcy) on the cognitive impairment after acute cerebral infarction.Methods: A total of 228 consecutive patients with acute cerebral infarction were enrolled and divided into the non-cognitive impairment group and cognitive impairment group according to the Montreal cognitive assessment.The potential risk factors of the cognitive impairment in two groups were analyzed using univariate analysis method,the significant indicators of which was analzyed using logistic regression analysis method,and the relative risk degree of the cognitive impairment after cerebral infarction was assessed by the level of plasma Hcy.Results: Logistic regression analysis showed that the age,education level,diabetes and Hcy level(the OR value for 0.94,1.21,1.86 and 2.35) were the independent influence factors of cognitive impairment after acute cerebral infarction.The level of Hcy in cognitive impairment group[(14.87±5.85)μmol/L] was significantly higher than that in non-cognitive impairment group[(12.78±5.68) μmol/L](P<0.01).The incidence rate of the cognitive impairment in patients with hyperhomocysteinemia was higher than that in patients without hyperhomocysteinemia,and the relative risk degree and 95%CI value of patients with hyperhomocysteinemia to those without hyperhomocysteinemia were 1.92,and 1.125 to 3.289,respectively.Conclusions: Plasma Hcy is the important influence factor of cognitive impairment after acute cerebral infarction.Hyperuricemia increases the risk of the cognitive impairment in cerebral infarction patients.
Objective: To investigate the effects of the level of plasma homocysteine(Hcy) on the cognitive impairment after acute cerebral infarction.Methods: A total of 228 consecutive patients with acute cerebral infarction were enrolled and divided into the non-cognitive impairment group and cognitive impairment group according to the Montreal cognitive assessment.The potential risk factors of the cognitive impairment in two groups were analyzed using univariate analysis method,the significant indicators of which was analzyed using logistic regression analysis method,and the relative risk degree of the cognitive impairment after cerebral infarction was assessed by the level of plasma Hcy.Results: Logistic regression analysis showed that the age,education level,diabetes and Hcy level(the OR value for 0.94,1.21,1.86 and 2.35) were the independent influence factors of cognitive impairment after acute cerebral infarction.The level of Hcy in cognitive impairment group[(14.87±5.85)μmol/L] was significantly higher than that in non-cognitive impairment group[(12.78±5.68) μmol/L](P<0.01).The incidence rate of the cognitive impairment in patients with hyperhomocysteinemia was higher than that in patients without hyperhomocysteinemia,and the relative risk degree and 95%CI value of patients with hyperhomocysteinemia to those without hyperhomocysteinemia were 1.92,and 1.125 to 3.289,respectively.Conclusions: Plasma Hcy is the important influence factor of cognitive impairment after acute cerebral infarction.Hyperuricemia increases the risk of the cognitive impairment in cerebral infarction patients.
2016, 41(11): 1465-1467.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.019
Abstract:
Objective: To explore the relationship between the concentration of lipopolysaccharide binding protein(LBP) and premature rupture of membrane(PROM),and provide a reference in diagnosing PROM and subclinical intra-amniotic infection(IAI).Methods: Sixty PROM patients were divided into the premature PROM(pPROM) group and term PROM(tPROM) group(30 cases each group),and 30 normal full-term pregnancy women were set as the control group.The serum LBP levels before delivery in three groups were detected using ELISA.Fetal membrane samples after delivery were examined using pathology technique.Results: The concentrations of LBP in pPROM group,tPROM group and control group were(125.22±37.51)μg/mL,(102.87±20.90)μg/mL and(66.09±31.17)μg/mL,respectively,the differences of which were statistically significant(P<0.01).The LBP concentrations in pPROM group and tPROM group were significantly higher than that in control group(P<0.01).There was a positive correlation between the serum LBP concentration and inflammation degree of the chorionic membrane in pPROM group(P<0.01).The concentration of serum LBP increased gradually(P<0.01).Conclusions: The serum level of LBP has a certain value in diagnosing PROM and PROM complicated with subclinical intra-amniotic infection.
Objective: To explore the relationship between the concentration of lipopolysaccharide binding protein(LBP) and premature rupture of membrane(PROM),and provide a reference in diagnosing PROM and subclinical intra-amniotic infection(IAI).Methods: Sixty PROM patients were divided into the premature PROM(pPROM) group and term PROM(tPROM) group(30 cases each group),and 30 normal full-term pregnancy women were set as the control group.The serum LBP levels before delivery in three groups were detected using ELISA.Fetal membrane samples after delivery were examined using pathology technique.Results: The concentrations of LBP in pPROM group,tPROM group and control group were(125.22±37.51)μg/mL,(102.87±20.90)μg/mL and(66.09±31.17)μg/mL,respectively,the differences of which were statistically significant(P<0.01).The LBP concentrations in pPROM group and tPROM group were significantly higher than that in control group(P<0.01).There was a positive correlation between the serum LBP concentration and inflammation degree of the chorionic membrane in pPROM group(P<0.01).The concentration of serum LBP increased gradually(P<0.01).Conclusions: The serum level of LBP has a certain value in diagnosing PROM and PROM complicated with subclinical intra-amniotic infection.
2016, 41(11): 1468-1471.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.020
Abstract:
Objective: To evaluate the clinical effects of the dental implantation using water sac stamping technique in maxillary sinus floor lifting in the repair of single-tooth loss.Methods: Thirty-six teeth were implanted in 36 patients with single-tooth loss complicated with 3.0 to 7.0 mm of height of alveolar crest in edentulous area using the flapless dental implantation combined with water sac stamping technique.All patients were regularly followed up after the surgery.The stability of the implant and condition of peri-implant tissues were observed.Results: During the 1-year period of following up,all implants were stable,no inflammation of the sinus were found.The soft tissue around the implants were healthy,the combination of dental implant and bone is good,and the height of maxillary sinus lifting bone is stabile.Conclusions: The short-term clinical effects of the dental implantation using water sac stamping technique in maxillary sinus floor lifting is ideal.
Objective: To evaluate the clinical effects of the dental implantation using water sac stamping technique in maxillary sinus floor lifting in the repair of single-tooth loss.Methods: Thirty-six teeth were implanted in 36 patients with single-tooth loss complicated with 3.0 to 7.0 mm of height of alveolar crest in edentulous area using the flapless dental implantation combined with water sac stamping technique.All patients were regularly followed up after the surgery.The stability of the implant and condition of peri-implant tissues were observed.Results: During the 1-year period of following up,all implants were stable,no inflammation of the sinus were found.The soft tissue around the implants were healthy,the combination of dental implant and bone is good,and the height of maxillary sinus lifting bone is stabile.Conclusions: The short-term clinical effects of the dental implantation using water sac stamping technique in maxillary sinus floor lifting is ideal.
2016, 41(11): 1471-1473.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.021
Abstract:
Objective: To study the efficacy and safety of metformin extended-release tablets on the metabolic disorder induced by antipsychotic.Methods: Seventy six schizophrenia patients with metabolic disorder induced by antipsychotic were divided into the treated group and control group randomly for 6 months.Monitor body mass index(BMI),fasting blood glucose(FBG) and blood lipid(TC,TG,LDL,HDL) at the end of 1,3 and 6 month.The Positive and Negative Symptom Scale(PANSS) and Treatment Emergent symptoms scale(TESS) were used to measure clinical efficacy.Results: It was decreased that BMI,TC,TG and LDL level at the end of 1 or 3 month in treated group,the differences were statistically significant(P<0.01),but there was no marked changes in the level of HDL and FBG(P>0.05).The differences of BMI,FBG,TG and HDL level were not significant in control group(P>0.05).At the end of 6 month,the differences of BMI,TC,TG,LDL and HDL level were statistically significant between the two groups(P<0.01).Before and after treatment,the scores of PANSS were not statistically significant between the two groups(P>0.05).Adverse reactions in the 2 groups were mild.Conclusions: It is effective and safe that metformin extended-release tablet treatment of metabolic disorder induced by antipsychotic,and does not affect the mental symptoms.
Objective: To study the efficacy and safety of metformin extended-release tablets on the metabolic disorder induced by antipsychotic.Methods: Seventy six schizophrenia patients with metabolic disorder induced by antipsychotic were divided into the treated group and control group randomly for 6 months.Monitor body mass index(BMI),fasting blood glucose(FBG) and blood lipid(TC,TG,LDL,HDL) at the end of 1,3 and 6 month.The Positive and Negative Symptom Scale(PANSS) and Treatment Emergent symptoms scale(TESS) were used to measure clinical efficacy.Results: It was decreased that BMI,TC,TG and LDL level at the end of 1 or 3 month in treated group,the differences were statistically significant(P<0.01),but there was no marked changes in the level of HDL and FBG(P>0.05).The differences of BMI,FBG,TG and HDL level were not significant in control group(P>0.05).At the end of 6 month,the differences of BMI,TC,TG,LDL and HDL level were statistically significant between the two groups(P<0.01).Before and after treatment,the scores of PANSS were not statistically significant between the two groups(P>0.05).Adverse reactions in the 2 groups were mild.Conclusions: It is effective and safe that metformin extended-release tablet treatment of metabolic disorder induced by antipsychotic,and does not affect the mental symptoms.
2016, 41(11): 1474-1477.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.022
Abstract:
Objective: To explore the effects of systemic chemotherapy combined with transcatheter arterial chemoembolization(TACE) in the treatment of breast cancer with hepatic metastasis.Methods: Sixty-eight breast cancer patients with liver metastasis were treated with systemic chemotherapy(32 cases,chemotherapy group),TACE(13 cases,embolism group),and systemic chemotherapy combined with transcatheter arterial chemoembolization(23 cases,combination group).The curative effect,adverse reaction and survival time between three groups were compared.Results: The total effective rate was 41.18%,the effective rates in chemotherapy group,embolism group and combination group were 43.75%,7.69% and 56.52%,respectively.The curative effect in combination group was better than that in embolism group(P<0.01),the difference of the curative effect between the combination group and chemotherapy group was not statistically significant(P>0.05).The median following-up time and survival time in all groups were 18 and 16 months,respectively.The median survival time in chemotherapy group and combination group was 19 months,and the median survival time in embolism group was 13 months,and the differences of the survival time between three groups were statistically significant(P<0.05).The gastrointestinal disorders,bone marrow suppression,hair loss and liver damage were the main adverse reactions in three groups.Conclusions: The treatment of the breast cancer with hepatic metastasis with systemic chemotherapy combined with TACE is good effect and less adverse reaction,which is worth in clinical further promotion.
Objective: To explore the effects of systemic chemotherapy combined with transcatheter arterial chemoembolization(TACE) in the treatment of breast cancer with hepatic metastasis.Methods: Sixty-eight breast cancer patients with liver metastasis were treated with systemic chemotherapy(32 cases,chemotherapy group),TACE(13 cases,embolism group),and systemic chemotherapy combined with transcatheter arterial chemoembolization(23 cases,combination group).The curative effect,adverse reaction and survival time between three groups were compared.Results: The total effective rate was 41.18%,the effective rates in chemotherapy group,embolism group and combination group were 43.75%,7.69% and 56.52%,respectively.The curative effect in combination group was better than that in embolism group(P<0.01),the difference of the curative effect between the combination group and chemotherapy group was not statistically significant(P>0.05).The median following-up time and survival time in all groups were 18 and 16 months,respectively.The median survival time in chemotherapy group and combination group was 19 months,and the median survival time in embolism group was 13 months,and the differences of the survival time between three groups were statistically significant(P<0.05).The gastrointestinal disorders,bone marrow suppression,hair loss and liver damage were the main adverse reactions in three groups.Conclusions: The treatment of the breast cancer with hepatic metastasis with systemic chemotherapy combined with TACE is good effect and less adverse reaction,which is worth in clinical further promotion.
2016, 41(11): 1480-1483.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.024
Abstract:
Objective: To compare the effects between Shang-ring circumcision and Sleeve circumcision on the quality of life.Methods: One hundred and thirty adult patients with redundant prepuce and phimosis were treated with Shang-ring circumcision(Shang-ring group,78 cases) and Sleeve circumcision(Sleeve group,52 cases).The quality of life between two groups after operation were compared.Results: The pain in Shang-ring group was more than that in Sleeve group in postoperative 2 weeks(P<0.01),which returned to the basic level and was less than that in Sleeve group in postoperative 3 to 4 weeks(P<0.01).The emotional change in Shang-ring group was more than that in Sleeve group in postoperative 2 weeks(P<0.05 to P<0.01),which returned to the basic level in two groups in postoperative 3 to 4 weeks(P<0.01).The daily activity in Shang-ring group was better than that in Sleeve group in postoperative 3 days(P<0.01),the difference of the daily activity score between two groups was not statistical significance(P>0.05).The physical composite scores after 1 to 2 weeks of operation and mental composite scores after 3 to 14 days of operation in Shang-ring group were significantly higher than those in Sleeve group(P<0.01).After 6 weeks of operation,the masturbation in patients treated with circumcision was difficult,the masturbation pleasure reduced and the effects of which on the quality of sexual life was not obvious.Conclusions: Two kinds of operations have different effects on the postoperative quality of life of patient.The circumcision can not improve the quality of sexual life,which has effect on masturbation.
Objective: To compare the effects between Shang-ring circumcision and Sleeve circumcision on the quality of life.Methods: One hundred and thirty adult patients with redundant prepuce and phimosis were treated with Shang-ring circumcision(Shang-ring group,78 cases) and Sleeve circumcision(Sleeve group,52 cases).The quality of life between two groups after operation were compared.Results: The pain in Shang-ring group was more than that in Sleeve group in postoperative 2 weeks(P<0.01),which returned to the basic level and was less than that in Sleeve group in postoperative 3 to 4 weeks(P<0.01).The emotional change in Shang-ring group was more than that in Sleeve group in postoperative 2 weeks(P<0.05 to P<0.01),which returned to the basic level in two groups in postoperative 3 to 4 weeks(P<0.01).The daily activity in Shang-ring group was better than that in Sleeve group in postoperative 3 days(P<0.01),the difference of the daily activity score between two groups was not statistical significance(P>0.05).The physical composite scores after 1 to 2 weeks of operation and mental composite scores after 3 to 14 days of operation in Shang-ring group were significantly higher than those in Sleeve group(P<0.01).After 6 weeks of operation,the masturbation in patients treated with circumcision was difficult,the masturbation pleasure reduced and the effects of which on the quality of sexual life was not obvious.Conclusions: Two kinds of operations have different effects on the postoperative quality of life of patient.The circumcision can not improve the quality of sexual life,which has effect on masturbation.
2016, 41(11): 1496-1498,1501.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.030
Abstract:
Objective: To investigate the pre-diabetes status of left-behind villagers from Lu'an for providing the measures in preventing and controlling the diabetes.Methods: The left-behind villagers(40 to 70 years old) from 18 administrative villages in Lu'an were randomly selected using the cluster sampling method,and investigated by questionnaire,and the blood glucose,height and body mess index of 3 546 villagers were measured.Results: The prevalence of pre-diabetes was 25.61%,and which in men and women were 25.14% and 25.86%,respectively.The awareness rate of the related knowledge of diabetes was low.The results of multiariable logistic regression analysis showed that people born after 1962 were the protection factors,the high body mass index was the risk factor(P<0.05 to P<0.01).Conclusions: Strengthening the health education of left-behind villagers and formulating the reasonable prevention measures can reduce or retard the transform of pre-diabetes to diabetes.
Objective: To investigate the pre-diabetes status of left-behind villagers from Lu'an for providing the measures in preventing and controlling the diabetes.Methods: The left-behind villagers(40 to 70 years old) from 18 administrative villages in Lu'an were randomly selected using the cluster sampling method,and investigated by questionnaire,and the blood glucose,height and body mess index of 3 546 villagers were measured.Results: The prevalence of pre-diabetes was 25.61%,and which in men and women were 25.14% and 25.86%,respectively.The awareness rate of the related knowledge of diabetes was low.The results of multiariable logistic regression analysis showed that people born after 1962 were the protection factors,the high body mass index was the risk factor(P<0.05 to P<0.01).Conclusions: Strengthening the health education of left-behind villagers and formulating the reasonable prevention measures can reduce or retard the transform of pre-diabetes to diabetes.
2016, 41(11): 1499-1501.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.031
Abstract:
Objective: To predict the per capita hospital cost in a county general hospital in 2015 in order to provide the evidence for the patients and health department formulating the health policy.Methods: The historical data of patients from 2006 to 2014 were analyzed.The linear regression model was established using the least sum of squares,the estimating standard error was calculated,and the forecasting model was amended.The per capita hospital cost in a county general hospital in 2015 was predicted using the regression model.Results: The relation of time(t) and per capita hospital cost(Y) was linear regression.With the time prolonging,the per capita hospital cost increased continuously.The predictive value of per capita hospital cost in a county general hospital in 2015 was 2907.63 Yuan,the 95% of the confidence interval was 2 563.72 to 3 521.54 Yuan.Conclusions: The per capita hospital cost increasing with years reflects the beneficial problems of health resource allocation.Some suggestions should be provided,which can lighten the burden of inpatient medical cost,and promote the development of hospital harmony.
Objective: To predict the per capita hospital cost in a county general hospital in 2015 in order to provide the evidence for the patients and health department formulating the health policy.Methods: The historical data of patients from 2006 to 2014 were analyzed.The linear regression model was established using the least sum of squares,the estimating standard error was calculated,and the forecasting model was amended.The per capita hospital cost in a county general hospital in 2015 was predicted using the regression model.Results: The relation of time(t) and per capita hospital cost(Y) was linear regression.With the time prolonging,the per capita hospital cost increased continuously.The predictive value of per capita hospital cost in a county general hospital in 2015 was 2907.63 Yuan,the 95% of the confidence interval was 2 563.72 to 3 521.54 Yuan.Conclusions: The per capita hospital cost increasing with years reflects the beneficial problems of health resource allocation.Some suggestions should be provided,which can lighten the burden of inpatient medical cost,and promote the development of hospital harmony.
2016, 41(11): 1502-1504,1506.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.032
Abstract:
Objective: To observe the effects of Oxymatrine on the drug sensitive test of the standard strain of E.coli in vitro.Methods: Oxymatrine were diluted to the 8 000 mg/L,4 000 mg/L,2 000 mg/L,1 000 mg/L,500 mg/L,250 mg/L,125 mg/L and 62.5 mg/L with 0.9% sodium chloride injection using the double dilution method.The containing-drug culture medium(each concentration of 3) were prepared according to the ratio of drug solution(MH agar for 1:9),and the blank and 0.9% sodium chloride injection were set as the control.After the E.coli recovery,the bacterium was inoculated to each medium using inoculating loop,and placed in 36℃ incubator for 24 h,and the result of which was observed.Results: The growth of E.coli in each culture medium containing-drug is good,the difference of the growth of E.coli in culture medium and control group is not obvious.Conclusions: The Oxymatrine has no effect on the growth of E.Coli.
Objective: To observe the effects of Oxymatrine on the drug sensitive test of the standard strain of E.coli in vitro.Methods: Oxymatrine were diluted to the 8 000 mg/L,4 000 mg/L,2 000 mg/L,1 000 mg/L,500 mg/L,250 mg/L,125 mg/L and 62.5 mg/L with 0.9% sodium chloride injection using the double dilution method.The containing-drug culture medium(each concentration of 3) were prepared according to the ratio of drug solution(MH agar for 1:9),and the blank and 0.9% sodium chloride injection were set as the control.After the E.coli recovery,the bacterium was inoculated to each medium using inoculating loop,and placed in 36℃ incubator for 24 h,and the result of which was observed.Results: The growth of E.coli in each culture medium containing-drug is good,the difference of the growth of E.coli in culture medium and control group is not obvious.Conclusions: The Oxymatrine has no effect on the growth of E.Coli.
2016, 41(11): 1504-1506.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.033
Abstract:
Objective: To evaluate the role of anti-cyclic citrullinated peptide(anti-CCP) antibody in the diagnosis of rheumatoid arthritis(RA).Methods: The present study comprised of clinically diagnosed RA patients(RA group),non-RA diseases(control groupⅠ) and healthy subjects(control groupⅡ).To compare the correlation among anti-CCP and rheumatoid factor(RF),they were analyzed by ELISA and immunoturbidimetric assay respectively.Results: The positive rate of anti-CCP antibody was 52.0%,6.0% and 0.0% respectively in RA group,control groupⅠ and control groupⅡ,with significant difference(P<0.01).There was no correlation between anti-CCP antibody and RF(P>0.05).Conclusions: Anti-CCP antibody is a relatively specific diagnosis of RA and the application of anti-CCP antibody in clinic can improve the diagnosis of RA.
Objective: To evaluate the role of anti-cyclic citrullinated peptide(anti-CCP) antibody in the diagnosis of rheumatoid arthritis(RA).Methods: The present study comprised of clinically diagnosed RA patients(RA group),non-RA diseases(control groupⅠ) and healthy subjects(control groupⅡ).To compare the correlation among anti-CCP and rheumatoid factor(RF),they were analyzed by ELISA and immunoturbidimetric assay respectively.Results: The positive rate of anti-CCP antibody was 52.0%,6.0% and 0.0% respectively in RA group,control groupⅠ and control groupⅡ,with significant difference(P<0.01).There was no correlation between anti-CCP antibody and RF(P>0.05).Conclusions: Anti-CCP antibody is a relatively specific diagnosis of RA and the application of anti-CCP antibody in clinic can improve the diagnosis of RA.
2016, 41(11): 1509-1511.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.035
Abstract:
Objective: To investigate the safety and effects on the comfort level of patients of the first compression time of TR Band after Transradial coronary intervention(TRI).Methods: One hundred patients treated with TR band hemostasis after TRI were divided into the observation group and control group according to the random number table(50 cases each group).The observation group were decompressed after postoperative 2 h,1 time each 2 h,discharge 2 mL each time for 3 times,and were completely discharged within 10 h.The control group were decompressed after postoperative 4 h,1 time each 2 h,discharge 2ml each time for 3 times,and were completely discharged within 12 h.The hemostasis effects,comfort level of patients,oxygen saturation(SpO2) of transcutaneous oppression side of forefinger and complications of oppression location between two groups were observation and compared.Results: Two decompression methods can effectively stop bleeding,the difference between the two groups was not statistically significant(P>0.05),the SpO2 level was within the normal range after 2 h of operation(P>0.05).The difference of the comfort level after 2 h of operation between two groups was not statistically significant(P>0.05);but the differences of the levels comfort and SpO2 after 4 h of operation between two groups were statistically significant(P<0.01).The differences of the incidences of ecchymosis,local blisters,cyanosis and numbness at different postoperative time between two groups were statistically significant(P<0.05 to P<0.01).Conclusions: The first decompression time of TR Band should be advanced to the postoperative 2 h,and the decompression time should be within the postoperative 10 h,which can reduce postoperative complications,and increase the comfort of patien.
Objective: To investigate the safety and effects on the comfort level of patients of the first compression time of TR Band after Transradial coronary intervention(TRI).Methods: One hundred patients treated with TR band hemostasis after TRI were divided into the observation group and control group according to the random number table(50 cases each group).The observation group were decompressed after postoperative 2 h,1 time each 2 h,discharge 2 mL each time for 3 times,and were completely discharged within 10 h.The control group were decompressed after postoperative 4 h,1 time each 2 h,discharge 2ml each time for 3 times,and were completely discharged within 12 h.The hemostasis effects,comfort level of patients,oxygen saturation(SpO2) of transcutaneous oppression side of forefinger and complications of oppression location between two groups were observation and compared.Results: Two decompression methods can effectively stop bleeding,the difference between the two groups was not statistically significant(P>0.05),the SpO2 level was within the normal range after 2 h of operation(P>0.05).The difference of the comfort level after 2 h of operation between two groups was not statistically significant(P>0.05);but the differences of the levels comfort and SpO2 after 4 h of operation between two groups were statistically significant(P<0.01).The differences of the incidences of ecchymosis,local blisters,cyanosis and numbness at different postoperative time between two groups were statistically significant(P<0.05 to P<0.01).Conclusions: The first decompression time of TR Band should be advanced to the postoperative 2 h,and the decompression time should be within the postoperative 10 h,which can reduce postoperative complications,and increase the comfort of patien.
2016, 41(11): 1512-1513,1517.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.036
Abstract:
Objective: To investigate the current status of critical thinking abilities in nursing undergraduate and specialists,and analyze its influencing factors.Methods: Five hundred nursing undergraduates and specialists selected by stratified cluster sampling were investigated using the general questionnaire and critical thinking skills measurement table.The influencing factors of critical thinking ability of nurses were analyzed using the non-conditional logistic regression model.Results: The total scores of critical thinking abilities in nursing undergraduates and specialist were(254.33±9.11) and(227.53±8.88),respectively.The scores of 7 dimensions of critical thinking ability and its total scores in nursing undergraduates were significantly higher than those in nursing specialists(P<0.01).The characteristics,student community activity and simulation teaching were the main influencing factors of critical thinking abilities of nurses(P<0.05 to P<0.01).Conclusions: Nursing undergraduates and specialist have positive critical thinking abilities,which is in the low or middle level.
Objective: To investigate the current status of critical thinking abilities in nursing undergraduate and specialists,and analyze its influencing factors.Methods: Five hundred nursing undergraduates and specialists selected by stratified cluster sampling were investigated using the general questionnaire and critical thinking skills measurement table.The influencing factors of critical thinking ability of nurses were analyzed using the non-conditional logistic regression model.Results: The total scores of critical thinking abilities in nursing undergraduates and specialist were(254.33±9.11) and(227.53±8.88),respectively.The scores of 7 dimensions of critical thinking ability and its total scores in nursing undergraduates were significantly higher than those in nursing specialists(P<0.01).The characteristics,student community activity and simulation teaching were the main influencing factors of critical thinking abilities of nurses(P<0.05 to P<0.01).Conclusions: Nursing undergraduates and specialist have positive critical thinking abilities,which is in the low or middle level.
2016, 41(11): 1514-1517.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.037
Abstract:
Objective: To explore the correlation between the postoperative pain degree and pain self-management behavior in patients with knee and hip osteoarthritis.Methods: The data of 127 operation patients with knee and hip arthritis were evaluated at admission.The pain intensities were evaluated using the Pain Assessment Questionnaire after 24 h,48 h and 72 h of operation.The pain intensity at the start of investigation,and the worst pain,lightest pain and average intensity of pain at past 24 h were investigated.The pain self-management behavior questionnaire was used to investigate the pain after 3 d of operation.The correlation between pain intensity and total score of pain self-management behavior was analyzed.Results: The proportions of the current pain,worst pain,lightest pain and average pain,which achieved a moderate degree or above,were 29.13%,100.00%,3.94% and 29.13%,respectively.The total score of postoperative pain self-management behavior was(18.99±3.67).Univariate analysis showed that the scores of postoperative pain self-management behavior in male,urban residents,high education level and history of surgery patients were higher than that in female,rural residents,low education level and no history of surgery patients(P<0.05 to P<0.01).The postoperative pain intensity was negative correlation with the score of pain self-management behavior(P<0.01).Conclusions: The postoperative pain control and pain self-management ability in patients with knee and hip arthritis are poor.In clinical pain management,the patients' own rolen and pain self-management ability should be improved,which can benefit to ease pain and improve the quality of life.
Objective: To explore the correlation between the postoperative pain degree and pain self-management behavior in patients with knee and hip osteoarthritis.Methods: The data of 127 operation patients with knee and hip arthritis were evaluated at admission.The pain intensities were evaluated using the Pain Assessment Questionnaire after 24 h,48 h and 72 h of operation.The pain intensity at the start of investigation,and the worst pain,lightest pain and average intensity of pain at past 24 h were investigated.The pain self-management behavior questionnaire was used to investigate the pain after 3 d of operation.The correlation between pain intensity and total score of pain self-management behavior was analyzed.Results: The proportions of the current pain,worst pain,lightest pain and average pain,which achieved a moderate degree or above,were 29.13%,100.00%,3.94% and 29.13%,respectively.The total score of postoperative pain self-management behavior was(18.99±3.67).Univariate analysis showed that the scores of postoperative pain self-management behavior in male,urban residents,high education level and history of surgery patients were higher than that in female,rural residents,low education level and no history of surgery patients(P<0.05 to P<0.01).The postoperative pain intensity was negative correlation with the score of pain self-management behavior(P<0.01).Conclusions: The postoperative pain control and pain self-management ability in patients with knee and hip arthritis are poor.In clinical pain management,the patients' own rolen and pain self-management ability should be improved,which can benefit to ease pain and improve the quality of life.
2016, 41(11): 1518-1520,1523.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.038
Abstract:
Objective: To explore the effects of the integrated Traditional Chinese and Western Medicine on the quality of life in patients with hypertensive cerebral hemorrhage.Methods: According to the digital table method,82 patients with hypertensive cerebral hemorrhage were divided into the observation group and control group(41 cases each group).Two groups were nursed using routine intervention(including health education,psychological care,close monitoring vital signs,guiding medication,rehabilitation training and diet instruction),and the observation group were additionally nursed with Chinese acupuncture and massage treatment.After 4 weeks of nursing intervention,the activities of daily living(ADL),limb motor function and effective rate between two groups were compared.Results: Compared with before intervention,the ADL and score of limb motor function in two groups were significantly improved after nursing intervention,the improvement in observation group was significantly better than that in control group(P<0.01).The difference of the treatment effects between two groups was not statistically significant(P>0.05).Conclusions: The combination of traditional Chinese and Western Medicine nursing intervention can improve the activities of daily living and limb motor function of patients with hypertensive cerebral hemorrhage.
Objective: To explore the effects of the integrated Traditional Chinese and Western Medicine on the quality of life in patients with hypertensive cerebral hemorrhage.Methods: According to the digital table method,82 patients with hypertensive cerebral hemorrhage were divided into the observation group and control group(41 cases each group).Two groups were nursed using routine intervention(including health education,psychological care,close monitoring vital signs,guiding medication,rehabilitation training and diet instruction),and the observation group were additionally nursed with Chinese acupuncture and massage treatment.After 4 weeks of nursing intervention,the activities of daily living(ADL),limb motor function and effective rate between two groups were compared.Results: Compared with before intervention,the ADL and score of limb motor function in two groups were significantly improved after nursing intervention,the improvement in observation group was significantly better than that in control group(P<0.01).The difference of the treatment effects between two groups was not statistically significant(P>0.05).Conclusions: The combination of traditional Chinese and Western Medicine nursing intervention can improve the activities of daily living and limb motor function of patients with hypertensive cerebral hemorrhage.
2016, 41(11): 1521-1523.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.039
Abstract:
Objective: To investigate the effects of humanistic nursing on the social function of male psychiatric patients.Methods: One hundred and twenty-nine male psychiatric patients were divided into the control group(64 cases) and observation group(65 cases).The control group and observation group were treated with routine nursing and humanistic nursing,respectively.The social function in two groups were evaluated and compared using the social function rating scale(SSPI) and the self insight and treatment attitude questionnaire(ITAQ).Results: The differences of the scores of SSPI and ITAQ before intervention between two groups were not statistically significant(P>0.05).Compared before intervention,the scores of SSPI and ITAQ in two groups increased significantly after intervention(P<0.01),and the total score of SSPI and each factor score,and the total score of ITAQ in observation group were significantly higher than those in control group(P<0.01).Conclusions: Humanistic nursing is beneficial to improve the social function of male psychiatric patients,which is worthy of clinical promotion.
Objective: To investigate the effects of humanistic nursing on the social function of male psychiatric patients.Methods: One hundred and twenty-nine male psychiatric patients were divided into the control group(64 cases) and observation group(65 cases).The control group and observation group were treated with routine nursing and humanistic nursing,respectively.The social function in two groups were evaluated and compared using the social function rating scale(SSPI) and the self insight and treatment attitude questionnaire(ITAQ).Results: The differences of the scores of SSPI and ITAQ before intervention between two groups were not statistically significant(P>0.05).Compared before intervention,the scores of SSPI and ITAQ in two groups increased significantly after intervention(P<0.01),and the total score of SSPI and each factor score,and the total score of ITAQ in observation group were significantly higher than those in control group(P<0.01).Conclusions: Humanistic nursing is beneficial to improve the social function of male psychiatric patients,which is worthy of clinical promotion.
2016, 41(11): 1524-1526.
doi: 10.13898/j.cnki.issn.1000-2200.2016.11.040
Abstract:
Objective: To investigate the effects of the bundle care on prevention the mouth opening difficulty in nasopharyngeal carcinoma patients after radiotherapy.Methods: One hundred and forty-eight nasopharyngeal carcinoma patients treated with radiotherapy were randomly divided into the treatment group(75 cases) and control group(73 cases).Two groups were treated with conventional care,and the treatment group were additionally treated with the bundle care.The incisor distances in all cases were measured before radiotherapy,at the end of radiotherapy and after 3 months of radiotherapy.The difficulty degrees of opening mouth in two groups treated with radiotherapy were observed for 1 year.Results: The opening mouth difficulty in two groups were found during the radiotherapy.The differences of the difficulty in mouth opening between two groups during the period of radiotherapy and after 3 months of radiotherapy were not statistically significant(P>0.05).The difficulty degrees in mouth opening in treatment group were significantly lower than that in control group after 6,9 and 12 month of radiotherapy(P<0.01).Conclusions: The bundle care can effectively reduce the incidence and degree of mouth opening difficulty.
Objective: To investigate the effects of the bundle care on prevention the mouth opening difficulty in nasopharyngeal carcinoma patients after radiotherapy.Methods: One hundred and forty-eight nasopharyngeal carcinoma patients treated with radiotherapy were randomly divided into the treatment group(75 cases) and control group(73 cases).Two groups were treated with conventional care,and the treatment group were additionally treated with the bundle care.The incisor distances in all cases were measured before radiotherapy,at the end of radiotherapy and after 3 months of radiotherapy.The difficulty degrees of opening mouth in two groups treated with radiotherapy were observed for 1 year.Results: The opening mouth difficulty in two groups were found during the radiotherapy.The differences of the difficulty in mouth opening between two groups during the period of radiotherapy and after 3 months of radiotherapy were not statistically significant(P>0.05).The difficulty degrees in mouth opening in treatment group were significantly lower than that in control group after 6,9 and 12 month of radiotherapy(P<0.01).Conclusions: The bundle care can effectively reduce the incidence and degree of mouth opening difficulty.
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