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2016 Vol. 41, No. 12
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2016, 41(12): 1541-1544.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.001
Abstract:
Objective: To investigate the expression profiles of differential long non-coding RNA(LncRNA) in spinal cord injury mice.Methods: The spinal cord injury mice model were established using MASCIS Impactor weight-drop device,and divided into the 1 d,3 d,7 d and 21 d groups according to the time of harvesting the injured spinal cord.The total RNA was extracted from the injured spine cord,which was used to RNA hybridization using microarray for constructing the different expression profile.The specific LncRNA of nerve tissue was validated by quantitative real-time polymerase chain reaction(qRT-PCR) to verify the reliability of the microarray.The signal pathway involved in the differential LncRNA was analyzed.Results: The differential expression of LncRNA was identified after the spinal cord injury,the expression of which arrived at the highest after 7 days of injury.The result of qRT-PCR showed that the reliability of microarray was good,and the differential LncRNA was involved in sevel signaling pathways.Conclusions: The LncRNA expression in the pathologic process is different after the spinal cord injury.
Objective: To investigate the expression profiles of differential long non-coding RNA(LncRNA) in spinal cord injury mice.Methods: The spinal cord injury mice model were established using MASCIS Impactor weight-drop device,and divided into the 1 d,3 d,7 d and 21 d groups according to the time of harvesting the injured spinal cord.The total RNA was extracted from the injured spine cord,which was used to RNA hybridization using microarray for constructing the different expression profile.The specific LncRNA of nerve tissue was validated by quantitative real-time polymerase chain reaction(qRT-PCR) to verify the reliability of the microarray.The signal pathway involved in the differential LncRNA was analyzed.Results: The differential expression of LncRNA was identified after the spinal cord injury,the expression of which arrived at the highest after 7 days of injury.The result of qRT-PCR showed that the reliability of microarray was good,and the differential LncRNA was involved in sevel signaling pathways.Conclusions: The LncRNA expression in the pathologic process is different after the spinal cord injury.
2016, 41(12): 1545-1549.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.002
Abstract:
Objective: To study the effects of recombinant human granulocyte colony stimulating factor(rhG-CSF) on the expression of apoptosis inducing factor(AIF) in neonatal SD rats.Methods: Thirty-six healthy neonatal SD rats with 7 days old were randomly divided into the sham operation group(group A),cerebral ischemia reperfusion group(group B) and drug treatment group(group C)(12 rats each group).The rat cerebral arterial occlusion reperfusion model was made using Longa suture blot method.The group C were injected with drug after two hours and 24 hours of cerebral ischemia,and the other two groups were injected with the same amount of normal saline.At the end of the experiment,the neural function of rat was evaluated by Longa 5 score method,the expressions of extracellular signal regulated protein kinase(p-ERK) and phosphorylated extracellular signal regulated protein kinase(p-JNK) were detected by immunohistochemical method,and the neuronal apoptosis and cerebral infarction volume were detected using Tunel and TTC staining,respectively.The levels of expression and apoptosis of apoptosis related genes were evaluated.Results: A small part of the apoptotic cells in A group and large number of apoptotic cells and brown nuclei in groups B and C after 24 h of reperfusion were found,which distributed mainly around the ischemic brain tissue,and which in C group was less than that in group B(P<0.01).Conclusions: rhG-CSF can protect the neuron of neonatal rat,and avoid the occurrence of ischemic hypoxic brain damage,which is related to the expression of the apoptosis related gene.
Objective: To study the effects of recombinant human granulocyte colony stimulating factor(rhG-CSF) on the expression of apoptosis inducing factor(AIF) in neonatal SD rats.Methods: Thirty-six healthy neonatal SD rats with 7 days old were randomly divided into the sham operation group(group A),cerebral ischemia reperfusion group(group B) and drug treatment group(group C)(12 rats each group).The rat cerebral arterial occlusion reperfusion model was made using Longa suture blot method.The group C were injected with drug after two hours and 24 hours of cerebral ischemia,and the other two groups were injected with the same amount of normal saline.At the end of the experiment,the neural function of rat was evaluated by Longa 5 score method,the expressions of extracellular signal regulated protein kinase(p-ERK) and phosphorylated extracellular signal regulated protein kinase(p-JNK) were detected by immunohistochemical method,and the neuronal apoptosis and cerebral infarction volume were detected using Tunel and TTC staining,respectively.The levels of expression and apoptosis of apoptosis related genes were evaluated.Results: A small part of the apoptotic cells in A group and large number of apoptotic cells and brown nuclei in groups B and C after 24 h of reperfusion were found,which distributed mainly around the ischemic brain tissue,and which in C group was less than that in group B(P<0.01).Conclusions: rhG-CSF can protect the neuron of neonatal rat,and avoid the occurrence of ischemic hypoxic brain damage,which is related to the expression of the apoptosis related gene.
2016, 41(12): 1549-1551.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.003
Abstract:
Objective: To study the apoptosis-inducing effects of curcumin(CUR) combined with paclitaxel(PA) on lung cancer cell line PC9.Methods: The PC9 cells were treated with different concentrations of single drug or two drugs combination.The anti-proliferative effect of drug was measured using MTT.The effects of single drug and two drugs combination on the cell cycle distribution and apoptosis were measured by flow cytometry.The expressions of apoptosis-related protein were detected by western blotting.Results: Two drugs could inhibit the prolification of PC9 cells with time-and concentration-dependent manner,and the profilication inhibiting rate of curcumin combined with paclitaxel was higher than that of CUR or PA.The apoptosis and G0/G1 phase arrest of PC9 cells treated with drug combination significantly enhanced(P<0.01).The protein expression changes of Caspase-3,Bcl-2 and Bax in PC9 cells teated with drug combination were significantly more than that with single drug(P<0.01).Conclusions: The CUR and PA can inhibit the proliferation of human lung cancer cell PC9,induce apoptosis,block cell G0/G1 phase and inprove the Caspase-3 activity.Two drugs combination can significnatly promote the PC9 cells apoptosis.
Objective: To study the apoptosis-inducing effects of curcumin(CUR) combined with paclitaxel(PA) on lung cancer cell line PC9.Methods: The PC9 cells were treated with different concentrations of single drug or two drugs combination.The anti-proliferative effect of drug was measured using MTT.The effects of single drug and two drugs combination on the cell cycle distribution and apoptosis were measured by flow cytometry.The expressions of apoptosis-related protein were detected by western blotting.Results: Two drugs could inhibit the prolification of PC9 cells with time-and concentration-dependent manner,and the profilication inhibiting rate of curcumin combined with paclitaxel was higher than that of CUR or PA.The apoptosis and G0/G1 phase arrest of PC9 cells treated with drug combination significantly enhanced(P<0.01).The protein expression changes of Caspase-3,Bcl-2 and Bax in PC9 cells teated with drug combination were significantly more than that with single drug(P<0.01).Conclusions: The CUR and PA can inhibit the proliferation of human lung cancer cell PC9,induce apoptosis,block cell G0/G1 phase and inprove the Caspase-3 activity.Two drugs combination can significnatly promote the PC9 cells apoptosis.
2016, 41(12): 1552-1555,1559.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.004
Abstract:
Objective: To explore the correlation between clinical objective biochemical indexes and liver tissue pathology chronic hepatitis B(CHB).Methods: The clinical data of liver tissue pathology and objective biochemical indexes in 468 CHB were collected from 2013 to 2015,the correlation of which were analyzed.Results: The inflammatory activity included G2 stage(70.1%,maxium),G4 stage (1.9%) and G0 stage(0.0%,minimum).Fibrosis stage included S2 stage(40.6%,maxium),S0 stage(9.0%) and S4 stage(4.3%,minimum).The inflammatory activity in different age patients was positively correlated with the fibrosis stage(P<0.05).With the increasing of age,the degree of liver inflammation and fibrosis gradually increased.Different lg10HBV-DNA was not corelated to the inflammatory activity(P>0.05),and positively correlated with fibrosis stage(P<0.05).Different levels of HBsAg and HBeAg were negatively correlated with the pathological inflammatory activity and fibrosis stage(P<0.05).The differences of the AST,ALB,GGT and PT between different inflammatory activity patients,and AST and GGT between different fibrosis stage patients were statistically significan(P<0.01).Conclusions: The clinical objective index in patients with CHB is correlation with the liver tissue pathology to some extent.The clinical objective index of patients can reflect the liver function and illness condition of patients to a certain extent,which can help to understand the condition of patient who cannot accept liver biopsy,and choose the antiviral treatment.
Objective: To explore the correlation between clinical objective biochemical indexes and liver tissue pathology chronic hepatitis B(CHB).Methods: The clinical data of liver tissue pathology and objective biochemical indexes in 468 CHB were collected from 2013 to 2015,the correlation of which were analyzed.Results: The inflammatory activity included G2 stage(70.1%,maxium),G4 stage (1.9%) and G0 stage(0.0%,minimum).Fibrosis stage included S2 stage(40.6%,maxium),S0 stage(9.0%) and S4 stage(4.3%,minimum).The inflammatory activity in different age patients was positively correlated with the fibrosis stage(P<0.05).With the increasing of age,the degree of liver inflammation and fibrosis gradually increased.Different lg10HBV-DNA was not corelated to the inflammatory activity(P>0.05),and positively correlated with fibrosis stage(P<0.05).Different levels of HBsAg and HBeAg were negatively correlated with the pathological inflammatory activity and fibrosis stage(P<0.05).The differences of the AST,ALB,GGT and PT between different inflammatory activity patients,and AST and GGT between different fibrosis stage patients were statistically significan(P<0.01).Conclusions: The clinical objective index in patients with CHB is correlation with the liver tissue pathology to some extent.The clinical objective index of patients can reflect the liver function and illness condition of patients to a certain extent,which can help to understand the condition of patient who cannot accept liver biopsy,and choose the antiviral treatment.
2016, 41(12): 1556-1559.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.005
Abstract:
Objective: To investigate the factor influencing the accuracy of diabetes treated with insulin bolus wizard pump calaculateor.Methods: A total of 100 type 2 diabetic patients were treated with insulin pump for 8 days,and the blood glucose level was measured for 8 times in a day.The patients were divided into 3 groups according to the mean blood glucose level of the first day.The insulin-to-carbohydrate ratio(ICR) and insulin sensitivity factor(ISF) between three groups were analyzed.Results: The ICR and ISF value in 3 groups significantly increased at 8th day of treatment(P<0.01),and the differences of ICR and ISF between three groups were statistically signifcant(P<0.01).The ICR and ISF were linearly negative correlation with the blood glucose level after breakfast,supper,and lunch(P<0.01).Conclusions: In the process of treating diabetes with bolus wizard,the ICR and ISF are related to the mean blood glucose level on the first day and glucose after meal.The timely adjusting the ICR and ISF can improve the accuracy of insulin use.
Objective: To investigate the factor influencing the accuracy of diabetes treated with insulin bolus wizard pump calaculateor.Methods: A total of 100 type 2 diabetic patients were treated with insulin pump for 8 days,and the blood glucose level was measured for 8 times in a day.The patients were divided into 3 groups according to the mean blood glucose level of the first day.The insulin-to-carbohydrate ratio(ICR) and insulin sensitivity factor(ISF) between three groups were analyzed.Results: The ICR and ISF value in 3 groups significantly increased at 8th day of treatment(P<0.01),and the differences of ICR and ISF between three groups were statistically signifcant(P<0.01).The ICR and ISF were linearly negative correlation with the blood glucose level after breakfast,supper,and lunch(P<0.01).Conclusions: In the process of treating diabetes with bolus wizard,the ICR and ISF are related to the mean blood glucose level on the first day and glucose after meal.The timely adjusting the ICR and ISF can improve the accuracy of insulin use.
2016, 41(12): 1560-1562.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.006
Abstract:
Objective: To investigate the effects of water birth on infant health.Methods: Four hundred and fifty-six healthy women were investigated using matched prospective cohort method.The pregnant women were divided into the water birth group and traditional birth group(228 cases each group).Two groups were matched according to the voluntary choice of water delivery.All cases were followed up at 1,6 and 12 months after delivery,which was used to investigate the infant health.Results: The differences of the birth weight,APGAR score,heath in neonatal hospitalization and within 1 month,and the incidence of disease during the following-up of 1 to 6 months and 7 to 12 months between two groups were not statistically significant(P>0.05).Conclusions: The water birth to baby is safe and reliable.
Objective: To investigate the effects of water birth on infant health.Methods: Four hundred and fifty-six healthy women were investigated using matched prospective cohort method.The pregnant women were divided into the water birth group and traditional birth group(228 cases each group).Two groups were matched according to the voluntary choice of water delivery.All cases were followed up at 1,6 and 12 months after delivery,which was used to investigate the infant health.Results: The differences of the birth weight,APGAR score,heath in neonatal hospitalization and within 1 month,and the incidence of disease during the following-up of 1 to 6 months and 7 to 12 months between two groups were not statistically significant(P>0.05).Conclusions: The water birth to baby is safe and reliable.
2016, 41(12): 1563-1565,1569.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.007
Abstract:
Objective: To examine the Willis circles of the patients with posterior circulation and no-posterior circulation transient ischemic attack(TIA) using the spiral CT angiography,and explore the correlation of Willis circle integrity with posterior circulation TIA.Methods: The cerebral vessels in 31 patients with posterior circulation TIA and 31 patients with no-posterior circulation TIA were analyzed using the spiral CT angiography.According to the results of examination,the Willis circles in all cases were divided into the complete,partial complete and incomplete circulation,respectively,and the variation of Willis circle was analyzed.Results: Different degree variation of Willis circles in two groups were found,and the incomplete Willis circles in patients with posterior circulation TIA were more.The difference between the complete and incomplete of posterior circulation in two groups was statistically significant(P<0.05),the difference between the complete and incomplete of anterior circulation in two groups was not statistically significant(P>0.05).Conclusions: The Willis circle integrity is correlation with the occurrence of posterior circulation TIA.
Objective: To examine the Willis circles of the patients with posterior circulation and no-posterior circulation transient ischemic attack(TIA) using the spiral CT angiography,and explore the correlation of Willis circle integrity with posterior circulation TIA.Methods: The cerebral vessels in 31 patients with posterior circulation TIA and 31 patients with no-posterior circulation TIA were analyzed using the spiral CT angiography.According to the results of examination,the Willis circles in all cases were divided into the complete,partial complete and incomplete circulation,respectively,and the variation of Willis circle was analyzed.Results: Different degree variation of Willis circles in two groups were found,and the incomplete Willis circles in patients with posterior circulation TIA were more.The difference between the complete and incomplete of posterior circulation in two groups was statistically significant(P<0.05),the difference between the complete and incomplete of anterior circulation in two groups was not statistically significant(P>0.05).Conclusions: The Willis circle integrity is correlation with the occurrence of posterior circulation TIA.
2016, 41(12): 1566-1569.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.008
Abstract:
Objective: To explore the differences of the expression levels of Maspin mRNA and protein in 5 kinds of human nasopharyngeal carcinoma cell lines with different metastatic behavior,and investigate its correlation for providing the theory basis in studying the metastasis mechanism of nasopharynx cancer and predicting clinical risk.Methods: The SUNE-1-5-8F,SUNE-1,CNE-2Z,CNE-1 and SUNE-1-6-10B human nasopharyngeal carcinoma cell lines with different metastatic behavior were cultivated in vitro.The expression levels of Maspin mRNA and protein in 5 kinds of human nasopharyngeal carcinoma cell lines were detected using RT-PCR and Western blot.Results: The differences of the expressions of Maspin gene in SUNE-1-5-8F,SUNE-1,CNE-1 and SUNE-1-6-10B cell lines were not statistically significant(P>0.05),and the Maspin expression in CNE-2Z cell line could not be detected.The expressions of Maspin mRNA and protein were consistent.The total expression contents of Maspin mRNA and protein in human nasopharyngeal carcinoma cell lines with different metastatic behavior were different(P<0.05),and the expression of which did not change with the increasing of metastatic behavior of cancer cells.Conclusions: The mRNA and protein expressions of Maspin gene in human nasopharyngeal carcinoma cell lines with different metastatic behavior are different,and the Maspin expression maybe be no-correlation with the metastatic potential of nasopharynx cancer cells.
Objective: To explore the differences of the expression levels of Maspin mRNA and protein in 5 kinds of human nasopharyngeal carcinoma cell lines with different metastatic behavior,and investigate its correlation for providing the theory basis in studying the metastasis mechanism of nasopharynx cancer and predicting clinical risk.Methods: The SUNE-1-5-8F,SUNE-1,CNE-2Z,CNE-1 and SUNE-1-6-10B human nasopharyngeal carcinoma cell lines with different metastatic behavior were cultivated in vitro.The expression levels of Maspin mRNA and protein in 5 kinds of human nasopharyngeal carcinoma cell lines were detected using RT-PCR and Western blot.Results: The differences of the expressions of Maspin gene in SUNE-1-5-8F,SUNE-1,CNE-1 and SUNE-1-6-10B cell lines were not statistically significant(P>0.05),and the Maspin expression in CNE-2Z cell line could not be detected.The expressions of Maspin mRNA and protein were consistent.The total expression contents of Maspin mRNA and protein in human nasopharyngeal carcinoma cell lines with different metastatic behavior were different(P<0.05),and the expression of which did not change with the increasing of metastatic behavior of cancer cells.Conclusions: The mRNA and protein expressions of Maspin gene in human nasopharyngeal carcinoma cell lines with different metastatic behavior are different,and the Maspin expression maybe be no-correlation with the metastatic potential of nasopharynx cancer cells.
2016, 41(12): 1570-1572.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.009
Abstract:
Objective: To investigate the clinical effects of two kinds of operation approaches in the treatment of asymmetry brain bilateral frontal lobe contusion.Methods: Thirty-two patients with asymmetry brain bilateral frontal contusion were randomly divided into the observation group and control group.The control group were treated with bilateral frontal craniotomy in coronal plane,and the observation group were treated with unilateral frontotemporal craniotomy.The operation time,intraoperative transfusion volume,olfactory nerve function injury and mental disorders between two groups were compared.The prognosis of all patients were assessed using the Glasgow Outcome Scale score after 3 months of operation.Results: The operation time and intraoperative transfusion volume,and number of patients with olfactory nerve function injury and mental disorders in observation group were lower than those in control group(P<0.05 to P<0.01).No death case was found during the following-up,and the difference of Glasgow Outcome Scale score between two groups was not statistically significant(P>0.05).Conclusions: Unilateral craniotomy in the treatment of asymmetry brain bilateral frontal lobe contusion is shorter operation time,less blood loss and nerve function injury,which is worthy of application under the strict surgical indications.
Objective: To investigate the clinical effects of two kinds of operation approaches in the treatment of asymmetry brain bilateral frontal lobe contusion.Methods: Thirty-two patients with asymmetry brain bilateral frontal contusion were randomly divided into the observation group and control group.The control group were treated with bilateral frontal craniotomy in coronal plane,and the observation group were treated with unilateral frontotemporal craniotomy.The operation time,intraoperative transfusion volume,olfactory nerve function injury and mental disorders between two groups were compared.The prognosis of all patients were assessed using the Glasgow Outcome Scale score after 3 months of operation.Results: The operation time and intraoperative transfusion volume,and number of patients with olfactory nerve function injury and mental disorders in observation group were lower than those in control group(P<0.05 to P<0.01).No death case was found during the following-up,and the difference of Glasgow Outcome Scale score between two groups was not statistically significant(P>0.05).Conclusions: Unilateral craniotomy in the treatment of asymmetry brain bilateral frontal lobe contusion is shorter operation time,less blood loss and nerve function injury,which is worthy of application under the strict surgical indications.
2016, 41(12): 1573-1576.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.010
Abstract:
Objective: To investigate the effects of intravenous injection of 0.1 mg/kg of oxycodone on the hemodynamics and stress response in diabetics treated with forgetfulness analgesia slow induction by transnasal catheter.Methods: Eighty stage ASA Ⅰ to Ⅱ diabetics(38 to 60 years old) were randomly divided into the oxycodone group(group O) and fentanyl group(group F)(40 cases each group).The group O and group F were treated with 0.1 mg/kg of oxycodone and 1 μg/kg of fentanyl by intravenous injection,respectively.The levels of SBP,DBP,HR,Epinephrine and Norepinephrine in two groups were measured before anesthesia induction(T0),tracheal tube through choana(T1),at the time of intubation(T2),after 3 min of intubation(T3) and after 10 min of intubation(T4).Results: Compared before operation,the SBP level in two group increased at T1 and T2(P<0.05),and decreased at T3 and T4(P<0.05).The increasing degree in group F was higher than that in group O(P<0.05).In group O,the SBP level did not obviously change during operation(P>0.05),and decreased after operation(P<0.05).In F group,the SBP level increased during operation(P<0.05),and decreased after operation(P<0.05).In two groups,the HR level increased during operation(P < 0.05),decreased after operation(P<0.05),and the increasing degree of HR in group F was higher than that in group O(P<0.05).The levels of Epinephrine and Norepinephrine in two group increased after T2(P<0.05),and the increasing degree of which in group F was higher than that in group O(P<0.05 to P<0.01).Conclusions: The 0.1 mg/kg of oxycodone in diabetics treated with forgetfulness analgesia slow induction by transnasal catheter can maintain the hemodynamic stability,significantly inhibit the stress response of body,and increase the safety of patients with type 2 diabetes during noncardiac surgery.
Objective: To investigate the effects of intravenous injection of 0.1 mg/kg of oxycodone on the hemodynamics and stress response in diabetics treated with forgetfulness analgesia slow induction by transnasal catheter.Methods: Eighty stage ASA Ⅰ to Ⅱ diabetics(38 to 60 years old) were randomly divided into the oxycodone group(group O) and fentanyl group(group F)(40 cases each group).The group O and group F were treated with 0.1 mg/kg of oxycodone and 1 μg/kg of fentanyl by intravenous injection,respectively.The levels of SBP,DBP,HR,Epinephrine and Norepinephrine in two groups were measured before anesthesia induction(T0),tracheal tube through choana(T1),at the time of intubation(T2),after 3 min of intubation(T3) and after 10 min of intubation(T4).Results: Compared before operation,the SBP level in two group increased at T1 and T2(P<0.05),and decreased at T3 and T4(P<0.05).The increasing degree in group F was higher than that in group O(P<0.05).In group O,the SBP level did not obviously change during operation(P>0.05),and decreased after operation(P<0.05).In F group,the SBP level increased during operation(P<0.05),and decreased after operation(P<0.05).In two groups,the HR level increased during operation(P < 0.05),decreased after operation(P<0.05),and the increasing degree of HR in group F was higher than that in group O(P<0.05).The levels of Epinephrine and Norepinephrine in two group increased after T2(P<0.05),and the increasing degree of which in group F was higher than that in group O(P<0.05 to P<0.01).Conclusions: The 0.1 mg/kg of oxycodone in diabetics treated with forgetfulness analgesia slow induction by transnasal catheter can maintain the hemodynamic stability,significantly inhibit the stress response of body,and increase the safety of patients with type 2 diabetes during noncardiac surgery.
2016, 41(12): 1577-1578,1582.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.011
Abstract:
Objective: To investigate the clinical value of preserving intercostobrachial nerve(ICBN) in modified radical mastectomy.Methods: Eighty-three breast cancer patients treated with modified radical mastectomy were divided into the observation group(41 cases treated with preserving ICBN) and control group(42 cases treated without preserving ICBN).All patients were followed up for 3 months to 3 years.The operation time,number of dissecting lymph nodes,indicence rate of sensory dysfunction,limb lymphedema rate and local recurrence rate between two groups were compared.Results: The mean operation time and number of dissecting lymph nodes in observation group were(113.56±5.78)min and(12.28±2.19),respectively.The mean operation time and number of dissecting lymph nodes in control group were(110.17±5.41)min and(12.83±2.13),respectively.The differences of the operation time,number of dissecting lymph nodes and limb lymphedema rate between two groups were not statistically significant(P>0.05).The postoperative sensory dysfunction rates in observation group and control group were 21.95% and 66.67%,respectivly,the difference of which between two groups was statistically significant(P<0.05).The local recurrence of tumor in two groups was not found during the following-up.Conclusions: During dissecting axillary lymph nodes in modified radical mastectomy,preserving ICBN can obviously decrease the incidence rate of sensory dysfunction in ipsilateral medial upper arm and chest wall,which is worthy of promoting.
Objective: To investigate the clinical value of preserving intercostobrachial nerve(ICBN) in modified radical mastectomy.Methods: Eighty-three breast cancer patients treated with modified radical mastectomy were divided into the observation group(41 cases treated with preserving ICBN) and control group(42 cases treated without preserving ICBN).All patients were followed up for 3 months to 3 years.The operation time,number of dissecting lymph nodes,indicence rate of sensory dysfunction,limb lymphedema rate and local recurrence rate between two groups were compared.Results: The mean operation time and number of dissecting lymph nodes in observation group were(113.56±5.78)min and(12.28±2.19),respectively.The mean operation time and number of dissecting lymph nodes in control group were(110.17±5.41)min and(12.83±2.13),respectively.The differences of the operation time,number of dissecting lymph nodes and limb lymphedema rate between two groups were not statistically significant(P>0.05).The postoperative sensory dysfunction rates in observation group and control group were 21.95% and 66.67%,respectivly,the difference of which between two groups was statistically significant(P<0.05).The local recurrence of tumor in two groups was not found during the following-up.Conclusions: During dissecting axillary lymph nodes in modified radical mastectomy,preserving ICBN can obviously decrease the incidence rate of sensory dysfunction in ipsilateral medial upper arm and chest wall,which is worthy of promoting.
2016, 41(12): 1579-1582.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.012
Abstract:
Objective: To investigate the value of the ischemia modified albumin(IMA),D-dimer combined with Wells scoring system in the diagnosis of pulmonary embolism(PE).Methods: Forty-six patients with suspected PE were examinated using multislice CT pulmonary angiography,and 20 PE cases,26 cases non-PE cases and 14 healthy people were divided into the PE group,non-PE group and control group,respectively.The levels of IMA and D-dimer in 3 groups were measured.The diagnostic value of IMA and D-dimer in PE patients were compared with ROC curve.Results: The levels of IMA and D-dimer in PE group were significantly higher than those in non-PE and control groups(P<0.01).The ROC curve showed that the most appropriate cut-off value of IMA was 63.45 U/mL,the sensitivity,specificity,positive predictive value and negative predictive value were 90.00%,76.90%,75.00% and 90.90%,respectively.The ROC curve showed that the most appropriate cut-off value of D-dimer was 0.795 mg/L,the sensitivity,specificity,positive predictive value and negative predictive value were 90.00%, 57.70%, 66.67% and 89.47%,respectively.The sensitivity,specificity,positive predictive value and negative predictive value of IMA combined with Wells scoring in diagnosing PE were 99.00%,38.45%,54.89% and 98.20%,respectively,and the sensitivity,specificity,positive predictive value and negative predictive value of D-dimer combined with Wells scoring in diagnosing PE were 99.00%,28.85%,51.29% and 97.45%,respectively.Conclusions: IMA can be used to diagnose PE,the diagnostic specificity of IMA is higher than that of the plasma D-dimer.The positive predictive value of IMA combined with Wells scoring in diagnosing PE is higher than that of D-dimer combined with Wells scoring,but the negative predictive value and sensitivity of the IMA combined with Wells scoring are similar to the D-dimer combined with Wells scoring.
Objective: To investigate the value of the ischemia modified albumin(IMA),D-dimer combined with Wells scoring system in the diagnosis of pulmonary embolism(PE).Methods: Forty-six patients with suspected PE were examinated using multislice CT pulmonary angiography,and 20 PE cases,26 cases non-PE cases and 14 healthy people were divided into the PE group,non-PE group and control group,respectively.The levels of IMA and D-dimer in 3 groups were measured.The diagnostic value of IMA and D-dimer in PE patients were compared with ROC curve.Results: The levels of IMA and D-dimer in PE group were significantly higher than those in non-PE and control groups(P<0.01).The ROC curve showed that the most appropriate cut-off value of IMA was 63.45 U/mL,the sensitivity,specificity,positive predictive value and negative predictive value were 90.00%,76.90%,75.00% and 90.90%,respectively.The ROC curve showed that the most appropriate cut-off value of D-dimer was 0.795 mg/L,the sensitivity,specificity,positive predictive value and negative predictive value were 90.00%, 57.70%, 66.67% and 89.47%,respectively.The sensitivity,specificity,positive predictive value and negative predictive value of IMA combined with Wells scoring in diagnosing PE were 99.00%,38.45%,54.89% and 98.20%,respectively,and the sensitivity,specificity,positive predictive value and negative predictive value of D-dimer combined with Wells scoring in diagnosing PE were 99.00%,28.85%,51.29% and 97.45%,respectively.Conclusions: IMA can be used to diagnose PE,the diagnostic specificity of IMA is higher than that of the plasma D-dimer.The positive predictive value of IMA combined with Wells scoring in diagnosing PE is higher than that of D-dimer combined with Wells scoring,but the negative predictive value and sensitivity of the IMA combined with Wells scoring are similar to the D-dimer combined with Wells scoring.
2016, 41(12): 1583-1586.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.013
Abstract:
Objective: To analyze the curative effects of the elastic intramedullary nail fixation combined with hip spica plaster external fixation in the treatment of subtrochanteric fracture.Methods: Thirteen children with subtrochanteric fractures were treated with the elastic intramedullary nail fixation combined with hip spica plaster external fixation under C arm machine.The injured limb function after treatment was evaluated using the standard scoring of the Flynn intramedullary nail in treating femoral fracture.Results: No surgical site infection and primary healing in all cases were found.During the 12 months of following up,the intramedullary nail fracture,nonunion,epiphyseal injury and disease limb dysfunction were not found,and the irritation symptom of nail tail in 2 children disppeared after removing the intramedullary nail.All fractures were bony union.The excellent in 12 cases and good in 1 case were identified according to the standard scoring of Flynn,and the excellence rate of which was 100%.Conclusions: Under grasping the standardized reduction and internal fixation skill,the treatment of subtrochanteric fracture with the elastic intramedullary nail fixation combined with hip spica plaster external fixation in children is good effect,minimal invasion,safe and an ideal method.
Objective: To analyze the curative effects of the elastic intramedullary nail fixation combined with hip spica plaster external fixation in the treatment of subtrochanteric fracture.Methods: Thirteen children with subtrochanteric fractures were treated with the elastic intramedullary nail fixation combined with hip spica plaster external fixation under C arm machine.The injured limb function after treatment was evaluated using the standard scoring of the Flynn intramedullary nail in treating femoral fracture.Results: No surgical site infection and primary healing in all cases were found.During the 12 months of following up,the intramedullary nail fracture,nonunion,epiphyseal injury and disease limb dysfunction were not found,and the irritation symptom of nail tail in 2 children disppeared after removing the intramedullary nail.All fractures were bony union.The excellent in 12 cases and good in 1 case were identified according to the standard scoring of Flynn,and the excellence rate of which was 100%.Conclusions: Under grasping the standardized reduction and internal fixation skill,the treatment of subtrochanteric fracture with the elastic intramedullary nail fixation combined with hip spica plaster external fixation in children is good effect,minimal invasion,safe and an ideal method.
2016, 41(12): 1586-1588.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.014
Abstract:
Objective: To compare the clinical effects of 3D laparoscopy with traditional laparoscopy in partial nephrectomy,and evaluate their practicability and safety.Methods: Among 42 limited renal tumor patients scheduled by operation,which were treated with partial nephrectomy under 3D laparoscopy(3D group,22 cases) and traditional laparoscopy(traditional group,20 cases),respectively.All operations were completed by the same operators.The operation time,warm ischemia time,peroperative bleeding,operation cost and complications between two groups were compared.Results: The operation time and warm ischemia time in 3D group were significantly less than those in traditional group(P<0.01 and P<0.05).The differences of the operation cost and peroperative bleeding between two groups were not statistical significance(P>0.05).One incision with delayed healing in 3D group and traditional group were found,which cured after conservative treatment.The surgical margins in two groups were negative.All cases were followed up for 6 to 48 months,no recurrence and metastasis,and normal kidney function were identified in two groups.Conclusions: Compared with the traditional laparoscopy surgery,the vision and anatomic structure under 3D laparoscopy are clear.The 3D laparoscopy can help to shorten the operation and warm ischemia time,which is worthy of clinic application.
Objective: To compare the clinical effects of 3D laparoscopy with traditional laparoscopy in partial nephrectomy,and evaluate their practicability and safety.Methods: Among 42 limited renal tumor patients scheduled by operation,which were treated with partial nephrectomy under 3D laparoscopy(3D group,22 cases) and traditional laparoscopy(traditional group,20 cases),respectively.All operations were completed by the same operators.The operation time,warm ischemia time,peroperative bleeding,operation cost and complications between two groups were compared.Results: The operation time and warm ischemia time in 3D group were significantly less than those in traditional group(P<0.01 and P<0.05).The differences of the operation cost and peroperative bleeding between two groups were not statistical significance(P>0.05).One incision with delayed healing in 3D group and traditional group were found,which cured after conservative treatment.The surgical margins in two groups were negative.All cases were followed up for 6 to 48 months,no recurrence and metastasis,and normal kidney function were identified in two groups.Conclusions: Compared with the traditional laparoscopy surgery,the vision and anatomic structure under 3D laparoscopy are clear.The 3D laparoscopy can help to shorten the operation and warm ischemia time,which is worthy of clinic application.
2016, 41(12): 1589-1591.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.015
Abstract:
Objective: To explore the significance of platelet(PLT),eosinophil,procalcitonin(PCT) and C-reactive protein(CRP) in judging the prognosis of patients with sepsis.Methods: One hundred patients with sepsis from department of emergency were divided into the survival group and death group according to the prognosis.The levels of PLT,eosinophil,PCT and CRP in two groups were observed.Results: The difference of the level of eosinophil in different prognosis patients was not statistically significnat(P>0.05),but the differences of the levels of PLT,PCT and CRP in different prognosis patients were statistically significnat(P<0.05 to P<0.01).The PCT and CRP could be analyzed using logistic regression model,while PLT could not.Conclusions: PLT is an independent influence factor for prognosis, PCT and CRP are the risk factors for sepsis,and eosinophil is not associated with the prognosis of patients with sepsis.
Objective: To explore the significance of platelet(PLT),eosinophil,procalcitonin(PCT) and C-reactive protein(CRP) in judging the prognosis of patients with sepsis.Methods: One hundred patients with sepsis from department of emergency were divided into the survival group and death group according to the prognosis.The levels of PLT,eosinophil,PCT and CRP in two groups were observed.Results: The difference of the level of eosinophil in different prognosis patients was not statistically significnat(P>0.05),but the differences of the levels of PLT,PCT and CRP in different prognosis patients were statistically significnat(P<0.05 to P<0.01).The PCT and CRP could be analyzed using logistic regression model,while PLT could not.Conclusions: PLT is an independent influence factor for prognosis, PCT and CRP are the risk factors for sepsis,and eosinophil is not associated with the prognosis of patients with sepsis.
2016, 41(12): 1591-1593.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.016
Abstract:
Objective: To investigate the clinical value of the fine membrane dissection in bilateral thyroid surgery.Methods: The clinical data of 62 patients treated with bilateral thyroid surgery from March 2015 to March 2016 were retrospectively analyzed.Thirty-two patients were treated with the fine membrane dissection technique(observation group),and 30 patients were treated with routine surgery(control group).The levels of PTH and blood calcium between two groups were compared before operation,and after 1 day,7 days and 1 month of surgery.Results: The levels of PTH and blood calcium in observation group at postoperative 1 day,7 days and 1 month were significantly higher than those in control group(P<0.05).Two groups were followed up for 3 months to 1 year,and no tumor recurrence and permanent hypocalcemia were found.Conclusions: During the bilateral thyroid surgery,applying the fine membrane dissecting technique,preserving the parathyroid gland in situ and more than secondary branching vessel derived from thyroid superior and inferior artery can effectively protect the parathyroid function and decrease the postoperative hypocalcemia.
Objective: To investigate the clinical value of the fine membrane dissection in bilateral thyroid surgery.Methods: The clinical data of 62 patients treated with bilateral thyroid surgery from March 2015 to March 2016 were retrospectively analyzed.Thirty-two patients were treated with the fine membrane dissection technique(observation group),and 30 patients were treated with routine surgery(control group).The levels of PTH and blood calcium between two groups were compared before operation,and after 1 day,7 days and 1 month of surgery.Results: The levels of PTH and blood calcium in observation group at postoperative 1 day,7 days and 1 month were significantly higher than those in control group(P<0.05).Two groups were followed up for 3 months to 1 year,and no tumor recurrence and permanent hypocalcemia were found.Conclusions: During the bilateral thyroid surgery,applying the fine membrane dissecting technique,preserving the parathyroid gland in situ and more than secondary branching vessel derived from thyroid superior and inferior artery can effectively protect the parathyroid function and decrease the postoperative hypocalcemia.
2016, 41(12): 1594-1596.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.017
Abstract:
Objective: To explore the expression levels of apoptosis stimulating protein of P53(ASPP) family genes in colon cancer tissue,and its correlation with clinical pathological features.Methods: Fifty colon cancer tissue specimens and 30 normal colon tissue specimens were investigated.The correlations of the ASPP family with the differentiation,depth of invasion and lymph node metastasis of colon cancer were analyzed.Results: The differences of the expressions of ASPP1 and ASPP2 between the colon cancer and normal colon tissue were not statistically significant(P>0.05),and the positive expression rate of iASPP in colon cancer was significantly higher than that in normal colon tissue(P<0.05).The differences of the positive expression rate of iASPP in different tumor pathological grading was not statistically significant(P>0.05),and the differences of the positive expression rate of ASPP1 and ASPP2 in different tumor pathological grading were statistically significant(P<0.05 and P<0.01).The differences of the positive expression rates of ASPP1 and iASPP in different tumor invasion depth were not statistically significant(P>0.05),and the difference of the positive expression rate of ASPP2 in different tumor invasion depth was statistically significant(P<0.05).The differences of the positive expression rates of ASPP1,ASPP2and iASPP in different lymph node metastasis of tumor were not statistically significant(P>0.05).Conclusions: The positive expression of iASPP between colon cancer and normal tissue is different,which may become one index in the diagnosis and differential diagnosis of colon malignant and benign diseases.The positive expression of ASPP2 is correlated with the pathological stage and grade of colon cancer,which may be one prognostic indicator of colon cancer.
Objective: To explore the expression levels of apoptosis stimulating protein of P53(ASPP) family genes in colon cancer tissue,and its correlation with clinical pathological features.Methods: Fifty colon cancer tissue specimens and 30 normal colon tissue specimens were investigated.The correlations of the ASPP family with the differentiation,depth of invasion and lymph node metastasis of colon cancer were analyzed.Results: The differences of the expressions of ASPP1 and ASPP2 between the colon cancer and normal colon tissue were not statistically significant(P>0.05),and the positive expression rate of iASPP in colon cancer was significantly higher than that in normal colon tissue(P<0.05).The differences of the positive expression rate of iASPP in different tumor pathological grading was not statistically significant(P>0.05),and the differences of the positive expression rate of ASPP1 and ASPP2 in different tumor pathological grading were statistically significant(P<0.05 and P<0.01).The differences of the positive expression rates of ASPP1 and iASPP in different tumor invasion depth were not statistically significant(P>0.05),and the difference of the positive expression rate of ASPP2 in different tumor invasion depth was statistically significant(P<0.05).The differences of the positive expression rates of ASPP1,ASPP2and iASPP in different lymph node metastasis of tumor were not statistically significant(P>0.05).Conclusions: The positive expression of iASPP between colon cancer and normal tissue is different,which may become one index in the diagnosis and differential diagnosis of colon malignant and benign diseases.The positive expression of ASPP2 is correlated with the pathological stage and grade of colon cancer,which may be one prognostic indicator of colon cancer.
2016, 41(12): 1597-1599.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.018
Abstract:
Objective: To investigate the relationships between the serum sex hormone and C-reactive protein(CRP) and erythrocyte sedimentation rate(ESR) levels in postmenopausal females with osteoarthritis(OA).Methods: Forty-two postmenopausal females with OA and 36 postmenopausal healthy examinees at the same time were divided into the observation group and control group,respectively.The levels of estradiol(E2),follicle stimulating hormone(FSH),testosterone(Te),luteinizing hormone(LH) in two groups were detected.The relationships between the sex hormone and CRP and ESR levels,were analyzed.Results: The levels of E2,FSH,Te and LH in observation group were significantly lower than those in control group(P<0.01),and the levels of CRP and ESR in observation group were significantly higher than those in control group(P<0.01 to P<0.05).In postmenopausal women with OA,the levels of E2,FSH and LH were not significantly correlated to the levels of CRP and ESR(P>0.05),and the Te level was negatively correlated to the levels of CRP and ESR(P<0.01).Conclusions: The pathogenesis of OA in postmenopausal females is closely related to the decreasing of the levels of serum E2,FSH,Te and LH and increasing of the levels of serum CRP and ESR,and the Te level is negatively correlated to the levels of CRP and ESR.
Objective: To investigate the relationships between the serum sex hormone and C-reactive protein(CRP) and erythrocyte sedimentation rate(ESR) levels in postmenopausal females with osteoarthritis(OA).Methods: Forty-two postmenopausal females with OA and 36 postmenopausal healthy examinees at the same time were divided into the observation group and control group,respectively.The levels of estradiol(E2),follicle stimulating hormone(FSH),testosterone(Te),luteinizing hormone(LH) in two groups were detected.The relationships between the sex hormone and CRP and ESR levels,were analyzed.Results: The levels of E2,FSH,Te and LH in observation group were significantly lower than those in control group(P<0.01),and the levels of CRP and ESR in observation group were significantly higher than those in control group(P<0.01 to P<0.05).In postmenopausal women with OA,the levels of E2,FSH and LH were not significantly correlated to the levels of CRP and ESR(P>0.05),and the Te level was negatively correlated to the levels of CRP and ESR(P<0.01).Conclusions: The pathogenesis of OA in postmenopausal females is closely related to the decreasing of the levels of serum E2,FSH,Te and LH and increasing of the levels of serum CRP and ESR,and the Te level is negatively correlated to the levels of CRP and ESR.
2016, 41(12): 1600-1601,1604.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.019
Abstract:
Objective: To discuss the optimal timing of the internal fixation in the treatment of multiple injuries complicated with femoral shaft fracture,and compare its curative effect.Methods: Ninety patients with multiple injuries complicated with femoral shaft fracture were divided into groups A,B and C(30 cases each group).The groups A,B and C were treated within 24 h,24 h to 72 h and 3 to 30 d after injury,respectively.Three groups were treated with open reduction combined with internal fixation.The mortality rate of surgery between three groups were compared.The optimal timing of the internal fixation in the treatment of multiple injuries complicated with femoral shaft fracture and its curative effects were analyzed.Results: Two cases(including 1 case with mild fracture and 1 case with severe fracture) died in group A(6.67%).Three cases(including 1 case with mild fracture and 2 cases with severe fracture) died in group B(10.00%).Seven cases(including 3 cases with mild fracture and 4 cases with severe fracture) died in group C(23.33%).The mortality rates in groups A,B and C were from high to low in turn,but the difference of which was not statistically significant(P>0.05).Conclusions: The later operation is,the higher the risk of operation and death in patients with multiple injuries and femoral shaft fracture is.The optimal treatment timing can obtain good treatment effects.
Objective: To discuss the optimal timing of the internal fixation in the treatment of multiple injuries complicated with femoral shaft fracture,and compare its curative effect.Methods: Ninety patients with multiple injuries complicated with femoral shaft fracture were divided into groups A,B and C(30 cases each group).The groups A,B and C were treated within 24 h,24 h to 72 h and 3 to 30 d after injury,respectively.Three groups were treated with open reduction combined with internal fixation.The mortality rate of surgery between three groups were compared.The optimal timing of the internal fixation in the treatment of multiple injuries complicated with femoral shaft fracture and its curative effects were analyzed.Results: Two cases(including 1 case with mild fracture and 1 case with severe fracture) died in group A(6.67%).Three cases(including 1 case with mild fracture and 2 cases with severe fracture) died in group B(10.00%).Seven cases(including 3 cases with mild fracture and 4 cases with severe fracture) died in group C(23.33%).The mortality rates in groups A,B and C were from high to low in turn,but the difference of which was not statistically significant(P>0.05).Conclusions: The later operation is,the higher the risk of operation and death in patients with multiple injuries and femoral shaft fracture is.The optimal treatment timing can obtain good treatment effects.
2016, 41(12): 1602-1604.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.020
Abstract:
Objective: To evaluate the clinical application value of calyceal fornix puncture guided by ultrasound in percutaneous nephrostolithotomy(PCNL).Methods: Two hundred and ninty-eight patients treated with primary PCNL were treated with calyceal fornix puncture guided by ultrasound(142 case,RF group) and non-calyceal fornix puncture(156 cases,NRF group).All cases were detected by CTU before operation.The patients with hypertension were treated with antihypertension,reducing blood sugar and antiinfection.The patients with urosepsis complicated with hydronephrosis were treated with renal drainage if the antiinfection effect was poor,and the patients were operated after the complication was improved.The tract number and diameter(average diameter of multi-tract),operation time of PCNL,tract bleeding rate,PCNL time,primary stone free rate,postoperative bleeding time,transfusing blood rate and renal artery embolization rate between two groups were compared.Results: The tract bleeding rate,PCNL time,postoperative bleeding time and transfusing blood rate in RF group were less than those in NRF group(P<0.05 to P<0.01),and the primary stone free rate in RF group was higher than that in NRF group(P<0.05).The differences of tract number and diameter between two groups were not statistically significant(P>0.05).Conclusions: The calyceal fornix puncture guided by ultrasound can decrease the bleeding and shorten operation time of PCNL,increase the primary stone free rate,and has a chance to use large size tract.
Objective: To evaluate the clinical application value of calyceal fornix puncture guided by ultrasound in percutaneous nephrostolithotomy(PCNL).Methods: Two hundred and ninty-eight patients treated with primary PCNL were treated with calyceal fornix puncture guided by ultrasound(142 case,RF group) and non-calyceal fornix puncture(156 cases,NRF group).All cases were detected by CTU before operation.The patients with hypertension were treated with antihypertension,reducing blood sugar and antiinfection.The patients with urosepsis complicated with hydronephrosis were treated with renal drainage if the antiinfection effect was poor,and the patients were operated after the complication was improved.The tract number and diameter(average diameter of multi-tract),operation time of PCNL,tract bleeding rate,PCNL time,primary stone free rate,postoperative bleeding time,transfusing blood rate and renal artery embolization rate between two groups were compared.Results: The tract bleeding rate,PCNL time,postoperative bleeding time and transfusing blood rate in RF group were less than those in NRF group(P<0.05 to P<0.01),and the primary stone free rate in RF group was higher than that in NRF group(P<0.05).The differences of tract number and diameter between two groups were not statistically significant(P>0.05).Conclusions: The calyceal fornix puncture guided by ultrasound can decrease the bleeding and shorten operation time of PCNL,increase the primary stone free rate,and has a chance to use large size tract.
2016, 41(12): 1605-1606,1609.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.021
Abstract:
Objective: To investigate the effects of non-drug intervention on the quality of life and blood pressure control in community hypertension patients.Methods: One hundred and sixty patients with hypertension were randomly divided into the observation group and control group(80 cases each group).The control group and observation group were intervened with drug and drug combined with non-drug,respectively.Results: After drug intervention,the difference of the clinical nursing satisfaction between two groups was not statistically significant(P>0.05),the difference of the incidence of heart failure between two groups was statistically significant(P<0.05).The blood pressure in two groups after intervention was better than that before intervention,and the blood pressure in observation group was better than that in control group(P<0.01).Conclusions: Compared with the community hypertension patients intervened with single drug,the drug intervention combined with non-drug intervention can improve the quality of life and control blood pressure of patients,which is worthy of use in clinic.
Objective: To investigate the effects of non-drug intervention on the quality of life and blood pressure control in community hypertension patients.Methods: One hundred and sixty patients with hypertension were randomly divided into the observation group and control group(80 cases each group).The control group and observation group were intervened with drug and drug combined with non-drug,respectively.Results: After drug intervention,the difference of the clinical nursing satisfaction between two groups was not statistically significant(P>0.05),the difference of the incidence of heart failure between two groups was statistically significant(P<0.05).The blood pressure in two groups after intervention was better than that before intervention,and the blood pressure in observation group was better than that in control group(P<0.01).Conclusions: Compared with the community hypertension patients intervened with single drug,the drug intervention combined with non-drug intervention can improve the quality of life and control blood pressure of patients,which is worthy of use in clinic.
2016, 41(12): 1607-1609.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.022
Abstract:
Objective: To compare the effects of different concentrations of levobupivacaine on intercostal nerve block guided by ultrasound.Methods: Ninety patients scheduled by unilateral breast tumor resection were randomly divided into three groups,and anaesthetized at 2 to 5 rib intercostal nerve block guided by ultrasound.The patients were anaesthetized with 24 mL of 0.25% levobupivacaine(group A),16 mL of 0.375% levobupivacaine(group B) and 12 mL of 0.5% levobupivacaine(group C),respectively.The onset time of anesthesia,complete anesthesia time,VAS scores at the beginning of cutting skin and stretching deep tissue,duration of analgesia,and the incidences of incomplete anesthesia and local anesthetic intoxication between three groups were observed.Results: With the increasing of the concentration of levobupivacaine,the onset time of anesthesia and complete anesthesia time shortened,and the analgesia time prolonged in 3 groups(P<0.05 to P<0.01).Conclusions: At the same dosage of levobupivacaine,the appropriate concentration of levobupivacaine at 2 to 5 rib intercostal nerve block anesthesia guided by ultrasound can shorten the anesthesia onset time and complete time,and prolong the analgesia duration.
Objective: To compare the effects of different concentrations of levobupivacaine on intercostal nerve block guided by ultrasound.Methods: Ninety patients scheduled by unilateral breast tumor resection were randomly divided into three groups,and anaesthetized at 2 to 5 rib intercostal nerve block guided by ultrasound.The patients were anaesthetized with 24 mL of 0.25% levobupivacaine(group A),16 mL of 0.375% levobupivacaine(group B) and 12 mL of 0.5% levobupivacaine(group C),respectively.The onset time of anesthesia,complete anesthesia time,VAS scores at the beginning of cutting skin and stretching deep tissue,duration of analgesia,and the incidences of incomplete anesthesia and local anesthetic intoxication between three groups were observed.Results: With the increasing of the concentration of levobupivacaine,the onset time of anesthesia and complete anesthesia time shortened,and the analgesia time prolonged in 3 groups(P<0.05 to P<0.01).Conclusions: At the same dosage of levobupivacaine,the appropriate concentration of levobupivacaine at 2 to 5 rib intercostal nerve block anesthesia guided by ultrasound can shorten the anesthesia onset time and complete time,and prolong the analgesia duration.
2016, 41(12): 1610-1612.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.023
Abstract:
Objective: To explore the screening significance of serum pepsinogenⅠ and Ⅱ(PG Ⅰ and PG Ⅱ) in elderly patients with chronic gastritis.Methods: Ninety-eight elderly patients with chronic gastritis diagnosed by gastroscopy and pathology were divided into the elderly group(52 cases,over 70 years old) and young and middle-aged group(46 cases,20 to 60 years old).The serum levels of PG Ⅰ and PG Ⅱ in two groups were measured,and the value of PGR(PGⅠ/PGⅡ) was calculated.Results: The levels of the PGⅠand PGR in patients with chronic atrophic gastritis were significantly lower than those in patients with chronic non-atrophic gastritis in two groups(P<0.01).The levels of the PGⅠand PGR in the elderly group were significantly lower than those in young and middle-aged group(P<0.01).The ROC curve of the chronic atrophic patients in elderly group showed that the critical value of PG Ⅰ,sensitivity and specificity were 98.06 μg/L,0.812 and 0.858,respectively,and the critical value of PGR,sensitivity and specificity were 6.68 μg/L,0.758 and 0.810,respectively.Conclusions: The detection of serum pepsinogen Ⅰ and Ⅱ has important clinic significance in screening elderly patients with chronic atrophic gastritis,which need to further define its reference range.
Objective: To explore the screening significance of serum pepsinogenⅠ and Ⅱ(PG Ⅰ and PG Ⅱ) in elderly patients with chronic gastritis.Methods: Ninety-eight elderly patients with chronic gastritis diagnosed by gastroscopy and pathology were divided into the elderly group(52 cases,over 70 years old) and young and middle-aged group(46 cases,20 to 60 years old).The serum levels of PG Ⅰ and PG Ⅱ in two groups were measured,and the value of PGR(PGⅠ/PGⅡ) was calculated.Results: The levels of the PGⅠand PGR in patients with chronic atrophic gastritis were significantly lower than those in patients with chronic non-atrophic gastritis in two groups(P<0.01).The levels of the PGⅠand PGR in the elderly group were significantly lower than those in young and middle-aged group(P<0.01).The ROC curve of the chronic atrophic patients in elderly group showed that the critical value of PG Ⅰ,sensitivity and specificity were 98.06 μg/L,0.812 and 0.858,respectively,and the critical value of PGR,sensitivity and specificity were 6.68 μg/L,0.758 and 0.810,respectively.Conclusions: The detection of serum pepsinogen Ⅰ and Ⅱ has important clinic significance in screening elderly patients with chronic atrophic gastritis,which need to further define its reference range.
2016, 41(12): 1613-1615,1618.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.024
Abstract:
Objective: To compare the clinical effects between retroperitoneal laparoscopic nephron-sparing Surgery(NSS) and radical nephrectomy(RN) in the treatment of stage T1b renal cell carcinoma.Methods: The clinical data of 33 patients with stage T1b renal cell carcinoma treated with retroperitoneal laparoscopic NSS(NSS group) and 20 patients with stage T1b renal cell carcinoma treated with RN(RN group) were retrospectively analyzed.Results: Fifty-three operations were successfully completed,and no case was conversed to open operation.The operation time in RN group was significantly less than that in NSS group(P<0.01).The eGFR in NSS groups after 3 and 6 months of operation were lower and higher than that in RN group,respectively(P<0.05).The differences of the peroperative bleeding,and postoperative extubation time,hospital stay and complications between two groups were not statistically significnat(P>0.05).Conclusions: For stage T1b renal cell carcinoma patients,if the cases is appropriate,the retroperitoneal laparoscopic NSS is safe and feasible,which can be considered as a priority operation type.
Objective: To compare the clinical effects between retroperitoneal laparoscopic nephron-sparing Surgery(NSS) and radical nephrectomy(RN) in the treatment of stage T1b renal cell carcinoma.Methods: The clinical data of 33 patients with stage T1b renal cell carcinoma treated with retroperitoneal laparoscopic NSS(NSS group) and 20 patients with stage T1b renal cell carcinoma treated with RN(RN group) were retrospectively analyzed.Results: Fifty-three operations were successfully completed,and no case was conversed to open operation.The operation time in RN group was significantly less than that in NSS group(P<0.01).The eGFR in NSS groups after 3 and 6 months of operation were lower and higher than that in RN group,respectively(P<0.05).The differences of the peroperative bleeding,and postoperative extubation time,hospital stay and complications between two groups were not statistically significnat(P>0.05).Conclusions: For stage T1b renal cell carcinoma patients,if the cases is appropriate,the retroperitoneal laparoscopic NSS is safe and feasible,which can be considered as a priority operation type.
2016, 41(12): 1616-1618.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.025
Abstract:
Objective: To compare the clinical effects between laparoscopy and laparotomy preserving anus sphincter surgery in low rectal cancer.Methods: Sixty-two patients with low rectal cancer were divided into the control group(27 cases) and observation group(35 cases).The control group and observation group were treated with laparotomy and laparoscopy preserving anus sphincter surgery,respectively.The perioperative situation,incidence of postoperative complications and specimen oncology and anus function after six months of operation between two groups were compared.Results: The operative time,blood loss,exhaust time and hospitalization time in observation group were significantly lower than those in control group(P<0.01).The differences of the postoperative anastomotic fistula,intestinal obstruction,intraperitoneal metastasis,ureteral injury and voiding dysfunction between two groups were not statistically significant(P>0.05).The differences of the average of diameter and length of tumor,distance from the distal edge of the tumor to the distal margin and number of lymph nodes dissected between two groups were not statistically significant(P>0.05).The differences of the incidence rate of totally anal incontinence and 6-month Kirwan standard anus control ability grading between two groups were not statistically significant(P>0.05).Conclusions: Laparoscopy preserving anus sphincter surgery in the treatment the low rectal cancer is small surgical trauma and quick postoperative recovery,the clinical effect of which can achieve the same radical cure of laparotomy preserving anus sphincter surgery.
Objective: To compare the clinical effects between laparoscopy and laparotomy preserving anus sphincter surgery in low rectal cancer.Methods: Sixty-two patients with low rectal cancer were divided into the control group(27 cases) and observation group(35 cases).The control group and observation group were treated with laparotomy and laparoscopy preserving anus sphincter surgery,respectively.The perioperative situation,incidence of postoperative complications and specimen oncology and anus function after six months of operation between two groups were compared.Results: The operative time,blood loss,exhaust time and hospitalization time in observation group were significantly lower than those in control group(P<0.01).The differences of the postoperative anastomotic fistula,intestinal obstruction,intraperitoneal metastasis,ureteral injury and voiding dysfunction between two groups were not statistically significant(P>0.05).The differences of the average of diameter and length of tumor,distance from the distal edge of the tumor to the distal margin and number of lymph nodes dissected between two groups were not statistically significant(P>0.05).The differences of the incidence rate of totally anal incontinence and 6-month Kirwan standard anus control ability grading between two groups were not statistically significant(P>0.05).Conclusions: Laparoscopy preserving anus sphincter surgery in the treatment the low rectal cancer is small surgical trauma and quick postoperative recovery,the clinical effect of which can achieve the same radical cure of laparotomy preserving anus sphincter surgery.
2016, 41(12): 1619-1622,1625.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.026
Abstract:
Objective: To compare the effects of the CYP2C19 *2,*3 non-functional allele on the curative effect of clopidogrel after percutaneous coronary stent implantation(PCI) between Han and Uygur patients.Methods: Four hundred acute coronary syndrome patients treated with PCI were divided into the clopidogrel normal metabolish group(group A) and weak clopidogrel normal metabolish group(group B) according to the result of CYP2C19 genetic testing.The group A and group B were treated with 75 mg and 150 mg of clopidogrel,respectively.Two groups were followed up for (30±3)d.The recurrences of the acute myocardial infarction,angina,cardiac death,stent thrombosis,nonfatal stroke,fatal and life-threatening bleeding were the primary endpoint events,and the minor bleeding and slight bleeding were the secondary endpoint events.The incidence of the endpoint event between two groups were compared.Results: The differences of the recurrence rate of the acute myocardial infarction(2.34% and 1.47%),angina(6.25% and 5.88%),cardiac death(0.78% and 0.00%),stent thrombosis(1.56% and 0.00%),and bleeding(5.47% and 7.35%) between Han and Uygur patients in group A were not statistically significant(P>0.05).The differences of the recurrence rate of the acute myocardial infarction(1.87% and 0.00%),angina(5.61% and 4.76%) and bleeding(3.74% and 4.76%) between Han and Uygur patients in group B were not statistically significant(P>0.05),and the cardiac death,stent thrombosis,nonfatal stroke,fatal and life-threatening bleeding were not found in Han and Uygur patients of group B.The differences of the recurrence rate of the acute myocardial infarction,angina and bleeding in Uygur patients between group A and group B were not statistically significant(P>0.05),and the cardiac death,stent thrombosis,nonfatal stroke,fatal and life-threatening bleeding were not found in Uygur patients of group A and group B.Conclusions: Among Uighur patients with the CYP2C19*2,*3 non-functional allele,the treatment of 150mg of clopidogrel per day can weaken the clopidogrel resistance,effectively reduce the incidence of major cardiovascular events,and does not increase the risk of bleeding.
Objective: To compare the effects of the CYP2C19 *2,*3 non-functional allele on the curative effect of clopidogrel after percutaneous coronary stent implantation(PCI) between Han and Uygur patients.Methods: Four hundred acute coronary syndrome patients treated with PCI were divided into the clopidogrel normal metabolish group(group A) and weak clopidogrel normal metabolish group(group B) according to the result of CYP2C19 genetic testing.The group A and group B were treated with 75 mg and 150 mg of clopidogrel,respectively.Two groups were followed up for (30±3)d.The recurrences of the acute myocardial infarction,angina,cardiac death,stent thrombosis,nonfatal stroke,fatal and life-threatening bleeding were the primary endpoint events,and the minor bleeding and slight bleeding were the secondary endpoint events.The incidence of the endpoint event between two groups were compared.Results: The differences of the recurrence rate of the acute myocardial infarction(2.34% and 1.47%),angina(6.25% and 5.88%),cardiac death(0.78% and 0.00%),stent thrombosis(1.56% and 0.00%),and bleeding(5.47% and 7.35%) between Han and Uygur patients in group A were not statistically significant(P>0.05).The differences of the recurrence rate of the acute myocardial infarction(1.87% and 0.00%),angina(5.61% and 4.76%) and bleeding(3.74% and 4.76%) between Han and Uygur patients in group B were not statistically significant(P>0.05),and the cardiac death,stent thrombosis,nonfatal stroke,fatal and life-threatening bleeding were not found in Han and Uygur patients of group B.The differences of the recurrence rate of the acute myocardial infarction,angina and bleeding in Uygur patients between group A and group B were not statistically significant(P>0.05),and the cardiac death,stent thrombosis,nonfatal stroke,fatal and life-threatening bleeding were not found in Uygur patients of group A and group B.Conclusions: Among Uighur patients with the CYP2C19*2,*3 non-functional allele,the treatment of 150mg of clopidogrel per day can weaken the clopidogrel resistance,effectively reduce the incidence of major cardiovascular events,and does not increase the risk of bleeding.
2016, 41(12): 1623-1625.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.027
Abstract:
Objective: To investigate the clinical efficacy and adverse reactions of low dose thalidomide combined with chemotherapy in the treatment of multiple myeloma(MM).Methods: Twenty-six patients with MM were divided into the observation group and control group according to the treatment method(13 cases each group).The control group were treated with conventional chemotherapy,and the observation group were treated with conventional chemotherapy combined with low dose thalidomide.The treatment effect,adverse reaction and prognosis between two groups were compared.Results: The effective rates in observation group and control group were 84.62% and 46.15%,respectively,the difference of which was statistically significant(P<0.05).The thrombocytopenia,leucopenia,mild rash,drowsiness,constipation and other symptoms in some cases were identified after treatment,which were partially relieved after treatment.The incidence rates of adverse reactions in observation group and control group were 38.46% and 46.15%,respectively,the difference of which was not statistically significant(P>0.05).The progression-free survival(PFS) and overall survival(OS) in observation group and control group were(5.6±1.3) & (11.6±2.5) months and (3.8±0.9) & (8.4±1.2) months,respectively.The PFS and OS in observation group were significantly longer than those in control group(P<0.01).Conclusions: The low dose thalidomide combined with conventional chemotherapy after treatment multiple myeloma is good effect and less adverse reaction,which can effectively prolong the survival of patients,and is worthy of promotion and application.
Objective: To investigate the clinical efficacy and adverse reactions of low dose thalidomide combined with chemotherapy in the treatment of multiple myeloma(MM).Methods: Twenty-six patients with MM were divided into the observation group and control group according to the treatment method(13 cases each group).The control group were treated with conventional chemotherapy,and the observation group were treated with conventional chemotherapy combined with low dose thalidomide.The treatment effect,adverse reaction and prognosis between two groups were compared.Results: The effective rates in observation group and control group were 84.62% and 46.15%,respectively,the difference of which was statistically significant(P<0.05).The thrombocytopenia,leucopenia,mild rash,drowsiness,constipation and other symptoms in some cases were identified after treatment,which were partially relieved after treatment.The incidence rates of adverse reactions in observation group and control group were 38.46% and 46.15%,respectively,the difference of which was not statistically significant(P>0.05).The progression-free survival(PFS) and overall survival(OS) in observation group and control group were(5.6±1.3) & (11.6±2.5) months and (3.8±0.9) & (8.4±1.2) months,respectively.The PFS and OS in observation group were significantly longer than those in control group(P<0.01).Conclusions: The low dose thalidomide combined with conventional chemotherapy after treatment multiple myeloma is good effect and less adverse reaction,which can effectively prolong the survival of patients,and is worthy of promotion and application.
2016, 41(12): 1626-1628.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.028
Abstract:
Objective: To explore the clinical application of seal colonic lavage in one-stage resection and anastomosis for left semicolonic carcinoma complicated with acute intestinal obstruction.Methods: Sixty-three patients with left semicolonic carcinoma complicated with acute intestinal obstruction were randomly divided into the control group(31 cases) and observation group(32 cases),and treated with one-stage resection and anastomosis.The obstruction in control group and observation group were removed with conventional method and seal colonic lavage,respectively.The clinical effect,complication and serum inflammatory indictor between two groups were compared.Results: The clinical total effective rate in observation group was higher than that in control group(P<0.05),and the difference of the incidence rate of the complication between two groups was not statistically significant(P>0.05).The differences of the levels of IL-6 and TNF-α between two groups before treatment were not statistically significant(P>0.05).The levels of IL-6 and TNF-α in observation group after treatment were significantly lower than those in control group(P<0.01).Conclusions: The seal colonic lavage in one-stage resection and anastomosis for left semicolonic carcinoma complicated with acute intestinal obstruction can completely clear the pathogen and contaminant in enteric cavity,which is benefit to control the postoperative infection and improve the recovery of patients.
Objective: To explore the clinical application of seal colonic lavage in one-stage resection and anastomosis for left semicolonic carcinoma complicated with acute intestinal obstruction.Methods: Sixty-three patients with left semicolonic carcinoma complicated with acute intestinal obstruction were randomly divided into the control group(31 cases) and observation group(32 cases),and treated with one-stage resection and anastomosis.The obstruction in control group and observation group were removed with conventional method and seal colonic lavage,respectively.The clinical effect,complication and serum inflammatory indictor between two groups were compared.Results: The clinical total effective rate in observation group was higher than that in control group(P<0.05),and the difference of the incidence rate of the complication between two groups was not statistically significant(P>0.05).The differences of the levels of IL-6 and TNF-α between two groups before treatment were not statistically significant(P>0.05).The levels of IL-6 and TNF-α in observation group after treatment were significantly lower than those in control group(P<0.01).Conclusions: The seal colonic lavage in one-stage resection and anastomosis for left semicolonic carcinoma complicated with acute intestinal obstruction can completely clear the pathogen and contaminant in enteric cavity,which is benefit to control the postoperative infection and improve the recovery of patients.
2016, 41(12): 1629-1631.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.029
Abstract:
Objective: To investigate the influencing factors of catheter-related bloodstream infection in patients with hemodialysis catheter.Methods: Three hundred and seventy-two patients with hemodialysis catheter in Department of Nephrology were divided into the infection group(38 cases) and control group(334 cases) according to the patients with catheter-related bloodstream infection.The clinical data of the patients were collected,and the catheter-related bloodstream infection factors were analyzed.Results: The incidence of catheter-related bloodstream infection and time of catheter infection in 372 patients were 10.22% and(25.46±8.72)d,respectively.Thirty-seven strains of pathogenic bacteria in catheter bloodstream infection were identified,which included 28 strains of Gram-positive bacteria(75.68%),7 strains of Gram-negative bacteria(18.92%) and 2 strains of fungi(5.40%).Multivariate Logistic regression analysis showed that diabetes mellitus,anemia,malnutrition,catheter indwelling in femoral vein and serum albumin less than 30 g/L were the risk factors of catheter bloodstream infection.Conclusions: Taking targeted measures against the risk factor of catheter bloodstream infection can reduce the incidence of catheter infection,and improve the survival rate of patients with hemodialysis.
Objective: To investigate the influencing factors of catheter-related bloodstream infection in patients with hemodialysis catheter.Methods: Three hundred and seventy-two patients with hemodialysis catheter in Department of Nephrology were divided into the infection group(38 cases) and control group(334 cases) according to the patients with catheter-related bloodstream infection.The clinical data of the patients were collected,and the catheter-related bloodstream infection factors were analyzed.Results: The incidence of catheter-related bloodstream infection and time of catheter infection in 372 patients were 10.22% and(25.46±8.72)d,respectively.Thirty-seven strains of pathogenic bacteria in catheter bloodstream infection were identified,which included 28 strains of Gram-positive bacteria(75.68%),7 strains of Gram-negative bacteria(18.92%) and 2 strains of fungi(5.40%).Multivariate Logistic regression analysis showed that diabetes mellitus,anemia,malnutrition,catheter indwelling in femoral vein and serum albumin less than 30 g/L were the risk factors of catheter bloodstream infection.Conclusions: Taking targeted measures against the risk factor of catheter bloodstream infection can reduce the incidence of catheter infection,and improve the survival rate of patients with hemodialysis.
2016, 41(12): 1632-1634.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.030
Abstract:
Objective: To evaluate the effects of locking plate combined with bone cement in the treatment of femoral supracondylar fracture in elderly patients.Methods: Fifty-six elderly patients with femoral condyle fracture were divided into the control group and observation group(28 cases each group).The control group and observation group were treated with locking plate and locking plate combined with bone cement,respectively.The knee joint functions in two groups were evaluated using the Merchan grading standard after operation.Results: The excellent and good rate in control group(60.7%) was significantly lower than that in observation group(75.0%)(P<0.01).Conclusions: The treatment of femoral supracondylar fracture with locking plate combineded with bone cement in elderly patients is simple operation,reliable fixation and good function recovery of knee joint after operation.
Objective: To evaluate the effects of locking plate combined with bone cement in the treatment of femoral supracondylar fracture in elderly patients.Methods: Fifty-six elderly patients with femoral condyle fracture were divided into the control group and observation group(28 cases each group).The control group and observation group were treated with locking plate and locking plate combined with bone cement,respectively.The knee joint functions in two groups were evaluated using the Merchan grading standard after operation.Results: The excellent and good rate in control group(60.7%) was significantly lower than that in observation group(75.0%)(P<0.01).Conclusions: The treatment of femoral supracondylar fracture with locking plate combineded with bone cement in elderly patients is simple operation,reliable fixation and good function recovery of knee joint after operation.
2016, 41(12): 1635-1638.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.031
Abstract:
Objective: To explore the troponin I mechanism of action ulinastatin in sepsis patients by observing the change of cytokine,evaluate the efficacy of ulinastatin and significance of troponin I(cTnI) and C-reactive protein(CRP) in the disease condition and prognosis of sepsis.Methods: Sixty patients with sepsis were selected by the prospective controlled study,and randomly divided into the ulinastatin group(group A) and control group(group B).Based on the same conventional treatment,the group A were treated with 200,000 U ulinastatin by intravenous once 8 hours,and the group B were treated with the same amount of saline.Before treatment and after 48 h and 120 h of treatment,the acute physiology and chronic health evaluation scores(APACHE Ⅱ score) in all patients were investigated,the serum levels of tumor necrosis factor α(TNF-α),interleukin-10(IL-10),CRP and cTnI in two groups were detected,and the 28-day mortality in patients were calculate.Results: The differences of the serum levels of TNF-α,IL-10,cTnI and CRP,and the APACHE Ⅱ score between two groups before treatment were not statistically significant(P>0.05).After 48 h and 120 h of treatment,the levels of TNF-α,CRP and the APACHE Ⅱ score in group A were lower than those in group B(P<0.05 to P<0.01),and the level of IL-10 in group A was significantly higher than that in group B(P<0.01).Compared before treatment,the levels of cTnI and CRP,and the APACHEⅡ score in group A significantly decreased after 48 h and 120 h of treatment(P<0.01).The difference of the 28-day mortality between two groups was not statistically significant(P>0.05).Conclusions: The treatment of sepsis with ulinastatin can not reduce the 28-day mortality,but it can alleviate the inflammatory response,and improve the condition of patients,the mechanism of which may involve in decreasing the level of TNF-α and increasing the level of IL-10.
Objective: To explore the troponin I mechanism of action ulinastatin in sepsis patients by observing the change of cytokine,evaluate the efficacy of ulinastatin and significance of troponin I(cTnI) and C-reactive protein(CRP) in the disease condition and prognosis of sepsis.Methods: Sixty patients with sepsis were selected by the prospective controlled study,and randomly divided into the ulinastatin group(group A) and control group(group B).Based on the same conventional treatment,the group A were treated with 200,000 U ulinastatin by intravenous once 8 hours,and the group B were treated with the same amount of saline.Before treatment and after 48 h and 120 h of treatment,the acute physiology and chronic health evaluation scores(APACHE Ⅱ score) in all patients were investigated,the serum levels of tumor necrosis factor α(TNF-α),interleukin-10(IL-10),CRP and cTnI in two groups were detected,and the 28-day mortality in patients were calculate.Results: The differences of the serum levels of TNF-α,IL-10,cTnI and CRP,and the APACHE Ⅱ score between two groups before treatment were not statistically significant(P>0.05).After 48 h and 120 h of treatment,the levels of TNF-α,CRP and the APACHE Ⅱ score in group A were lower than those in group B(P<0.05 to P<0.01),and the level of IL-10 in group A was significantly higher than that in group B(P<0.01).Compared before treatment,the levels of cTnI and CRP,and the APACHEⅡ score in group A significantly decreased after 48 h and 120 h of treatment(P<0.01).The difference of the 28-day mortality between two groups was not statistically significant(P>0.05).Conclusions: The treatment of sepsis with ulinastatin can not reduce the 28-day mortality,but it can alleviate the inflammatory response,and improve the condition of patients,the mechanism of which may involve in decreasing the level of TNF-α and increasing the level of IL-10.
2016, 41(12): 1639-1641.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.032
Abstract:
Objective: To investigate the effects of oral administration of rosuvastain on the lung function and quality of life in stable chronic obstructive pulmonary disease(COPD) patients.Methods: Eighty-eight patients with COPD were randomly divided into the observation group and the control group(44 cases each group).The control group were treated with conventional therapy,and the observation group were treated with 20 mg rosuvastain by oral,once a day for 6 months based on conventional therapy.The first second forced expiratory volume(FEV1) and ratio of FEV1 to forced vital capacity(FVC) in patients were determined before treatment and after 1 and 6 months of treatment,which was used to evaluate the lung function of patients.The quality of life of patients was evaluated using the CAT scale.Results: The FEV1 level after 6 months of treatment,and ratio of FEV1 to FVC after 1 and 6 months of treatment in two groups were higher than higher those before treatment(P<0.01),and the ratio of FEV1 to FVC after 6 months of treatment in observation group was higher than that in control group.The CAT score in observation group after 1 and 6 months of treatment and score of CAT in control group after 1 mouth of 6 months were lower than those before treatment(P<0.01),and the scores of CAT in observation group affter 1 and 6 months of treatment were lower than that in control group(P<0.01).Conclusions: The rosuvastain can improve the lung function and quality of life in patients with COPD,the curative effect of which is distinct,and worthy of popularization and application.
Objective: To investigate the effects of oral administration of rosuvastain on the lung function and quality of life in stable chronic obstructive pulmonary disease(COPD) patients.Methods: Eighty-eight patients with COPD were randomly divided into the observation group and the control group(44 cases each group).The control group were treated with conventional therapy,and the observation group were treated with 20 mg rosuvastain by oral,once a day for 6 months based on conventional therapy.The first second forced expiratory volume(FEV1) and ratio of FEV1 to forced vital capacity(FVC) in patients were determined before treatment and after 1 and 6 months of treatment,which was used to evaluate the lung function of patients.The quality of life of patients was evaluated using the CAT scale.Results: The FEV1 level after 6 months of treatment,and ratio of FEV1 to FVC after 1 and 6 months of treatment in two groups were higher than higher those before treatment(P<0.01),and the ratio of FEV1 to FVC after 6 months of treatment in observation group was higher than that in control group.The CAT score in observation group after 1 and 6 months of treatment and score of CAT in control group after 1 mouth of 6 months were lower than those before treatment(P<0.01),and the scores of CAT in observation group affter 1 and 6 months of treatment were lower than that in control group(P<0.01).Conclusions: The rosuvastain can improve the lung function and quality of life in patients with COPD,the curative effect of which is distinct,and worthy of popularization and application.
2016, 41(12): 1642-1646.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.033
Abstract:
Objective: To analyze the clinicopathological features,treatment and prognosis of patients with breast cancer,and investigate the influencing factors of prognosis.Methods: The clinical data of the clinicopathological characteristics,recurrence,metastasis and survival in 338 breast cancer patients diagnosed by pathology were retrospectively analyzed,and the influencing prognosis factor was investigated by survival analysis.Results: All patients were followed up for 4 to 115 months,and the median follow-up time was 42 months.The 5-year disease-free survival(DFS) and 5-year overall survival(OS) rates were 77.46% and 81.69%,respectively.The univariate analysis indicated that the tumor size,number of lymph node metastasis and radiotherapy were the influencing factors of DFS and OS(P<0.01).The multivariate Cox regression analysis indicated that the tumor size and number of lymph node metastasis were the independent influencing factor of DFS and OS in breast cancer pateints.Conclusions: The tumor size and number of lymph node metastasis are the independent influencing factor of prognosis in patients with breast cancer.
Objective: To analyze the clinicopathological features,treatment and prognosis of patients with breast cancer,and investigate the influencing factors of prognosis.Methods: The clinical data of the clinicopathological characteristics,recurrence,metastasis and survival in 338 breast cancer patients diagnosed by pathology were retrospectively analyzed,and the influencing prognosis factor was investigated by survival analysis.Results: All patients were followed up for 4 to 115 months,and the median follow-up time was 42 months.The 5-year disease-free survival(DFS) and 5-year overall survival(OS) rates were 77.46% and 81.69%,respectively.The univariate analysis indicated that the tumor size,number of lymph node metastasis and radiotherapy were the influencing factors of DFS and OS(P<0.01).The multivariate Cox regression analysis indicated that the tumor size and number of lymph node metastasis were the independent influencing factor of DFS and OS in breast cancer pateints.Conclusions: The tumor size and number of lymph node metastasis are the independent influencing factor of prognosis in patients with breast cancer.
2016, 41(12): 1647-1650,1654.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.034
Abstract:
Objective: To explore the effects of transverse annular compression suture(TACS) hemostasis in lower uterine with placenta previa complicated with placenta accreta during cesarean section.Methods: Seventy-two puerperas with placenta previa complicated with placenta accreta were treated with cesarean section from January 2013 to January 2015,and randomly divided into the group A(42 cases) and group B(30 cases).The group A and group B were treated with TACS combined with repair hemostasis and traditional “8-type” suture combined wih balloon compression hemostasis,respectively.The drug usage,hemostasis effect,coagulation,postpartum complications,uterine involution and maternal mental between two groups were compared.Results: The Hemabate usage in group A was significantly lower than that in group B(P<0.05),the blooding before intervention,intervention and after intervention,and total blood loss in group A were significantly lower than those in group B(P<0.05) and the transfusion rate and blood transfusion in group A were significantly lower than those in group B(P<0.05).The difference of hysterectomy rate between group A(0.00%) and group B(43.33%) was statistically significant(P<0.05).The uterine involution rate in group A(100.00%) was significantly higher than that in group B(56.67 %)(P<0.05).The postpartum Self-rating Anxiety Scale and Self-rating Depression Scale scores in group A were significantly lower than those in group B(P<0.05).Conclusions: Compared with the compression hemostasis in womb,the effect of transverse annular compression suture hemostasis in lower uterine with placenta previa complicated with placenta accreta during cesarean section is good,which can effectively shorten the operation time,reduce the intraoperative blooding and hysterectomy rate,improve postpartum mental state and coagulation function,and has certain clinical value.
Objective: To explore the effects of transverse annular compression suture(TACS) hemostasis in lower uterine with placenta previa complicated with placenta accreta during cesarean section.Methods: Seventy-two puerperas with placenta previa complicated with placenta accreta were treated with cesarean section from January 2013 to January 2015,and randomly divided into the group A(42 cases) and group B(30 cases).The group A and group B were treated with TACS combined with repair hemostasis and traditional “8-type” suture combined wih balloon compression hemostasis,respectively.The drug usage,hemostasis effect,coagulation,postpartum complications,uterine involution and maternal mental between two groups were compared.Results: The Hemabate usage in group A was significantly lower than that in group B(P<0.05),the blooding before intervention,intervention and after intervention,and total blood loss in group A were significantly lower than those in group B(P<0.05) and the transfusion rate and blood transfusion in group A were significantly lower than those in group B(P<0.05).The difference of hysterectomy rate between group A(0.00%) and group B(43.33%) was statistically significant(P<0.05).The uterine involution rate in group A(100.00%) was significantly higher than that in group B(56.67 %)(P<0.05).The postpartum Self-rating Anxiety Scale and Self-rating Depression Scale scores in group A were significantly lower than those in group B(P<0.05).Conclusions: Compared with the compression hemostasis in womb,the effect of transverse annular compression suture hemostasis in lower uterine with placenta previa complicated with placenta accreta during cesarean section is good,which can effectively shorten the operation time,reduce the intraoperative blooding and hysterectomy rate,improve postpartum mental state and coagulation function,and has certain clinical value.
2016, 41(12): 1651-1654.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.035
Abstract:
Objective: To investigate the colonization rate of the group B streptococcus(GBS) in the reproductive tract of terminal pregnant women and its high risk factors,and explore the effects of GBS infection on the outcome of full-term pregnancy.Methods: The GBS in 884 pregnant women with gestation age for 35 to 37 weeks were detected using fluorescence quantitation polymerase chain reaction,the microorganism from vaginal secretion in all cases were also detected,the pregnant outcome were observed.Results: The antenatal positive rate of GBS in 884 pregnant women was 10.4%,and the positive rates of the bacterial vaginitis,trichomonal vaginitis and mould vaginitis were 8.1%,1.2% and 6.7%,respectively.The difference of the positive rate of mould between the GBS positive and negative pregnant women was not statistically significant(P>0.05).The positive rates of trichomonad and bacterial vaginal diseases in GBS positive pregnant women were significantly higher than those in GBS negative pregnant women(P<0.01).The differences of the incidences of cesarean section,postpartum hemorrhage,meconium pollution of amniotic fluid,premature rupture for membranes and puerperal infection between the GBS positive and negative pregnant women were not statistically significant(P>0.05).The differences of the incidence of fetus distress,neonate asphyxia and neonatal infection and pathological jaundice between the GBS positive and negative pregnant women were not statistically significant(P>0.05).Conclusions: The colonization rate of GBS is closely related to the vaginal inflammation of terminal pregnant women.The GBS positive pregnant women should be treated with sensitive antibiotics,but the bad outcome of full-term pregnancy can not be significantly improved after treatment.
Objective: To investigate the colonization rate of the group B streptococcus(GBS) in the reproductive tract of terminal pregnant women and its high risk factors,and explore the effects of GBS infection on the outcome of full-term pregnancy.Methods: The GBS in 884 pregnant women with gestation age for 35 to 37 weeks were detected using fluorescence quantitation polymerase chain reaction,the microorganism from vaginal secretion in all cases were also detected,the pregnant outcome were observed.Results: The antenatal positive rate of GBS in 884 pregnant women was 10.4%,and the positive rates of the bacterial vaginitis,trichomonal vaginitis and mould vaginitis were 8.1%,1.2% and 6.7%,respectively.The difference of the positive rate of mould between the GBS positive and negative pregnant women was not statistically significant(P>0.05).The positive rates of trichomonad and bacterial vaginal diseases in GBS positive pregnant women were significantly higher than those in GBS negative pregnant women(P<0.01).The differences of the incidences of cesarean section,postpartum hemorrhage,meconium pollution of amniotic fluid,premature rupture for membranes and puerperal infection between the GBS positive and negative pregnant women were not statistically significant(P>0.05).The differences of the incidence of fetus distress,neonate asphyxia and neonatal infection and pathological jaundice between the GBS positive and negative pregnant women were not statistically significant(P>0.05).Conclusions: The colonization rate of GBS is closely related to the vaginal inflammation of terminal pregnant women.The GBS positive pregnant women should be treated with sensitive antibiotics,but the bad outcome of full-term pregnancy can not be significantly improved after treatment.
2016, 41(12): 1665-1667.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.040
Abstract:
Objective: To compare the value between TI-RADS scoring and ultrasound elastography grading in the diagnosis of benign and malignant thyroid nodules.Methods: Among 90 nodules from 64 patients,the data of 68 benign nodules and 22 malignant nodules identified by pathology were analyzed.The routine ultrasound and ultrasound elasticity imaging of 90 nodules were examined,the results of two examination methods were compared with pathology findings.Results: TI-RADS scoring method showed that 69 nodules were benign,and 21 nodules were malignant.Elastography results showed that 67 nodules were benign,and 23 nodules were malignant.Compared with the pathology results,the sensitivity,specificity,and accuracy of the TI-RADS scoring and elastography were 90.9%,98.5% and 96.7%,and 86.4%,94.1% and 92.2%,respectively.Conclusions: Both TI-RADS scoring method and ultrasound elastography grading method are valuable method to diagnose benign and malignant thyroid nodules.TI-RADS scoring method has more unity of objective standard,higher accuracy and wider application range.
Objective: To compare the value between TI-RADS scoring and ultrasound elastography grading in the diagnosis of benign and malignant thyroid nodules.Methods: Among 90 nodules from 64 patients,the data of 68 benign nodules and 22 malignant nodules identified by pathology were analyzed.The routine ultrasound and ultrasound elasticity imaging of 90 nodules were examined,the results of two examination methods were compared with pathology findings.Results: TI-RADS scoring method showed that 69 nodules were benign,and 21 nodules were malignant.Elastography results showed that 67 nodules were benign,and 23 nodules were malignant.Compared with the pathology results,the sensitivity,specificity,and accuracy of the TI-RADS scoring and elastography were 90.9%,98.5% and 96.7%,and 86.4%,94.1% and 92.2%,respectively.Conclusions: Both TI-RADS scoring method and ultrasound elastography grading method are valuable method to diagnose benign and malignant thyroid nodules.TI-RADS scoring method has more unity of objective standard,higher accuracy and wider application range.
2016, 41(12): 1668-1669,1672.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.041
Abstract:
Objective: To study the value of dimensional ultrasound combined with color Doppler flow imaging in the diagnosis of bladder cancer.Methods: Sixty-four patients with bladder cancer were diagnosed by dimensional ultrasound combined with color Doppler flow imaging before operation,which were compared with the results of pathobiology.Results: The diagnosis coincidence rates of the benign and malignant bladder tumor between the dimensional ultrasound combined with color Doppler flow imaging and pathology were 87.5% and 94.4%,respectively.Conclusions: The dimensional ultrasound combined with color Doppler flow imaging in diagnosing bladder tumor is high accuracy and credibility,which is worthy of clinical application.
Objective: To study the value of dimensional ultrasound combined with color Doppler flow imaging in the diagnosis of bladder cancer.Methods: Sixty-four patients with bladder cancer were diagnosed by dimensional ultrasound combined with color Doppler flow imaging before operation,which were compared with the results of pathobiology.Results: The diagnosis coincidence rates of the benign and malignant bladder tumor between the dimensional ultrasound combined with color Doppler flow imaging and pathology were 87.5% and 94.4%,respectively.Conclusions: The dimensional ultrasound combined with color Doppler flow imaging in diagnosing bladder tumor is high accuracy and credibility,which is worthy of clinical application.
2016, 41(12): 1670-1672.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.042
Abstract:
Objective: To investigate the ultrasound diagnostic features of esophageal hiatal hernia in infants,and its correlation with the clinical surgery.Methods: The ultrasound image features of esophageal hiatal hernia diagnosed by ultrasound,gastrointestinal imaging and operation in 15 infants were retrospectively analyzed.The enlarging inner diameter of the esophageal hiatus and 45 normal esophageal hiatus were statistically analyzed.The inside tissue of hernia above diaphragm was detected,and the effect of which on thoracic organ was investigated.Results: Fifteen infants with esophageal hiatal hernia were diagnosed by ultrasound,gastrointestinal imaging combined with operation,the diagnostic coincidence rate was 100%.The inner diameter of the esophageal hiatal hernia in esophageal hiatal group increased at various degree,the difference of which between two groups was statistically significant(P<0.05).The ultrasound detection showed that the inside tissue of hernia included 15 cases of stomach,14 cases of cardia,14 cases of lower esophagus,3 cases of the part liver and 1 case of bowel,and these tissue could enter alone or together.The atelectasis in 2 cases and cardiac displacement in 1 case were identified.Conclusions: The ultrasound characteristics of esophageal hiatal hernia is obvious in infant.Measuring the inside diameter of esophageal hiatus and probing the tissue above the diaphragm and cardiopulmonary oppression can contribute to judge the esophageal hiatal hernia type,and operate as possible as early in clinic.Ultrasound may become the preferred method of noninvasive screening the esophageal hiatal hernia in infants.
Objective: To investigate the ultrasound diagnostic features of esophageal hiatal hernia in infants,and its correlation with the clinical surgery.Methods: The ultrasound image features of esophageal hiatal hernia diagnosed by ultrasound,gastrointestinal imaging and operation in 15 infants were retrospectively analyzed.The enlarging inner diameter of the esophageal hiatus and 45 normal esophageal hiatus were statistically analyzed.The inside tissue of hernia above diaphragm was detected,and the effect of which on thoracic organ was investigated.Results: Fifteen infants with esophageal hiatal hernia were diagnosed by ultrasound,gastrointestinal imaging combined with operation,the diagnostic coincidence rate was 100%.The inner diameter of the esophageal hiatal hernia in esophageal hiatal group increased at various degree,the difference of which between two groups was statistically significant(P<0.05).The ultrasound detection showed that the inside tissue of hernia included 15 cases of stomach,14 cases of cardia,14 cases of lower esophagus,3 cases of the part liver and 1 case of bowel,and these tissue could enter alone or together.The atelectasis in 2 cases and cardiac displacement in 1 case were identified.Conclusions: The ultrasound characteristics of esophageal hiatal hernia is obvious in infant.Measuring the inside diameter of esophageal hiatus and probing the tissue above the diaphragm and cardiopulmonary oppression can contribute to judge the esophageal hiatal hernia type,and operate as possible as early in clinic.Ultrasound may become the preferred method of noninvasive screening the esophageal hiatal hernia in infants.
2016, 41(12): 1673-1675.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.043
Abstract:
Objective: To investigate the characteristics of brain metabolites in patients with vascular cognitive impairment(VCI) using magnetic resonance spectroscopy(MRS).Methods: Twenty-six patients with vascular cognitive impairment no dementia(VCIND group),20 patients with vascular dementia(VaD group) and 20 normal people(control group) were investigated.The levels of the N-acetyl aspartate(NAA),choline(Cho),creatine(Cr),and the metabolite ratios of NAA/Cr and Cho/Cr in left rear of the cingulate gyrus,left dorsal thalamus,left frontal white matter(FLWM) and left hippocampus in three groups were measured and compared.Results: Compared with the control group,the metabolite ratio of NAA/Cr in left rear of the cingulate gyrus,left frontal white matter and left hippocampus decreased in VCIND patients(P<0.05 to P<0.01),the level of NAA in left rear of the cingulate gyrus,left dorsal thalamus and left hippocampus decreased in VaD patients(P<0.05 to P<0.01),and the metabolite ratio of NAA/Cr in left rear of the cingulate gyrus,left frontal white matter and left hippocampus decreased in VaD group(P<0.01).The differences of the level of Cho and Cho/Cr in different areas between 3 groups were not statistically significant(P>0.05).Compared with the VCIND group,the metabolite ratio of NAA/Cr in left rear of the cingulate gyrus,the level of NAA and metabolite ratio of NAA/Cr in left hippocampus decreased in VaD group(P<0.05 to P<0.01).Conclusions: The metabolite differences in different brain regions exist in VCIND and VaD patients,especially for changes of the level of NAA and the ratio of NAA/Cr.
Objective: To investigate the characteristics of brain metabolites in patients with vascular cognitive impairment(VCI) using magnetic resonance spectroscopy(MRS).Methods: Twenty-six patients with vascular cognitive impairment no dementia(VCIND group),20 patients with vascular dementia(VaD group) and 20 normal people(control group) were investigated.The levels of the N-acetyl aspartate(NAA),choline(Cho),creatine(Cr),and the metabolite ratios of NAA/Cr and Cho/Cr in left rear of the cingulate gyrus,left dorsal thalamus,left frontal white matter(FLWM) and left hippocampus in three groups were measured and compared.Results: Compared with the control group,the metabolite ratio of NAA/Cr in left rear of the cingulate gyrus,left frontal white matter and left hippocampus decreased in VCIND patients(P<0.05 to P<0.01),the level of NAA in left rear of the cingulate gyrus,left dorsal thalamus and left hippocampus decreased in VaD patients(P<0.05 to P<0.01),and the metabolite ratio of NAA/Cr in left rear of the cingulate gyrus,left frontal white matter and left hippocampus decreased in VaD group(P<0.01).The differences of the level of Cho and Cho/Cr in different areas between 3 groups were not statistically significant(P>0.05).Compared with the VCIND group,the metabolite ratio of NAA/Cr in left rear of the cingulate gyrus,the level of NAA and metabolite ratio of NAA/Cr in left hippocampus decreased in VaD group(P<0.05 to P<0.01).Conclusions: The metabolite differences in different brain regions exist in VCIND and VaD patients,especially for changes of the level of NAA and the ratio of NAA/Cr.
2016, 41(12): 1676-1678.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.044
Abstract:
Objective: To investigate the clinical value of CT perfusion imaging with acetazolamid(ACZ) excitation test combined with CT angiography in the diagnosis of chronic cerebral circulation insufficiency(CCCI).Methods: Fifty-two patients with CCCI and 48 healthy examination people were divided into the observation group and control group,respectively.The nervous system in all cases were comprehensively examined using ACZ perfusion imaging combined with CT angiography.The pons and basal layers were studied,and the supply blood area of vertebral basilar artery,and cerebral middle artery,anterior artery and posterior artery were labeled.The peak time of cerebral blood flow,cerebral blood volume,and mean transit time in symmetric area were measured using mirror image method.Results: The volume of the blood supply area of cerebral anterior artery before ACZ excitation in observation group was significantly higher than that in control group(P<0.01),and the peak time of supply blood area of cerebral middle artery was significantly higher than that in control group(P<0.01).After ACZ excitation,the differences of the related indicators of different brain areas were statistically significant(P<0.01).Conclusions: The ACZ perfusion imaging combined with CT angiography can effectively improve the detection rate of CCCI,which is easy to handle,high sensitivity,effective in early diagnosis,and has high clinical value.
Objective: To investigate the clinical value of CT perfusion imaging with acetazolamid(ACZ) excitation test combined with CT angiography in the diagnosis of chronic cerebral circulation insufficiency(CCCI).Methods: Fifty-two patients with CCCI and 48 healthy examination people were divided into the observation group and control group,respectively.The nervous system in all cases were comprehensively examined using ACZ perfusion imaging combined with CT angiography.The pons and basal layers were studied,and the supply blood area of vertebral basilar artery,and cerebral middle artery,anterior artery and posterior artery were labeled.The peak time of cerebral blood flow,cerebral blood volume,and mean transit time in symmetric area were measured using mirror image method.Results: The volume of the blood supply area of cerebral anterior artery before ACZ excitation in observation group was significantly higher than that in control group(P<0.01),and the peak time of supply blood area of cerebral middle artery was significantly higher than that in control group(P<0.01).After ACZ excitation,the differences of the related indicators of different brain areas were statistically significant(P<0.01).Conclusions: The ACZ perfusion imaging combined with CT angiography can effectively improve the detection rate of CCCI,which is easy to handle,high sensitivity,effective in early diagnosis,and has high clinical value.
Analysis of the direct economic loss of inpatient's nosocomial infection in a comprehensive hospital
2016, 41(12): 1686-1688.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.048
Abstract:
Objective: To analyze the direct economic loss and influencing factors of nosocomial infection of inpatient in a comprehensive hospital.Methods: The hospitalization time and cost in 50 nosocomial infection patients(case group) and 50 non-nosocomial infection patients(control group) were retrospectively analyzed using the 1:1 case-control method.The direct economic loss of nosocomial infection was calculated.Results: The hospitalization time and cost in case group(27±18) days and(42 669±36 845) Yuan were significantly higher than those in control group(15±7) days and(19 541±14 653)Yuan,respectively(P<0.01).The direct economic loss of lower respiratory tract,urinary tract,gastrontestinal,surgical site and bloodstream infections in case group was significantly worse than those in control group(P<0.01).Conclusions: The occurrence of nosocomial infection obviously increases the hospitalization time and cost of patients,which can cause the direct economic loss of patients.
Objective: To analyze the direct economic loss and influencing factors of nosocomial infection of inpatient in a comprehensive hospital.Methods: The hospitalization time and cost in 50 nosocomial infection patients(case group) and 50 non-nosocomial infection patients(control group) were retrospectively analyzed using the 1:1 case-control method.The direct economic loss of nosocomial infection was calculated.Results: The hospitalization time and cost in case group(27±18) days and(42 669±36 845) Yuan were significantly higher than those in control group(15±7) days and(19 541±14 653)Yuan,respectively(P<0.01).The direct economic loss of lower respiratory tract,urinary tract,gastrontestinal,surgical site and bloodstream infections in case group was significantly worse than those in control group(P<0.01).Conclusions: The occurrence of nosocomial infection obviously increases the hospitalization time and cost of patients,which can cause the direct economic loss of patients.
2016, 41(12): 1688-1690.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.049
Abstract:
Objective: To investigate the clinical effects of the predictive nursing on preventing the pressure ulcers in ICU patients.Methods: Sixty-eight severe patients from April 2011 to December 2012 were set as the control group,and 68 severe patients from January 2013 to August 2014 were set as the intervention group.The control group and intervention group were nursed with routine way and predictive pressure ulcer nursing,respectively.Results: The incidence rate of pressure ulcer in intervention group(19.12%) was significantly lower than that in control group(51.47%)(P<0.01).The severity of pressure ulcer in intervention group was lighter than that in control group(P<0.05).Conclusions: The application of the predictive nursing can effectively decrease the incidence rate and severity of pressure ulcers.
Objective: To investigate the clinical effects of the predictive nursing on preventing the pressure ulcers in ICU patients.Methods: Sixty-eight severe patients from April 2011 to December 2012 were set as the control group,and 68 severe patients from January 2013 to August 2014 were set as the intervention group.The control group and intervention group were nursed with routine way and predictive pressure ulcer nursing,respectively.Results: The incidence rate of pressure ulcer in intervention group(19.12%) was significantly lower than that in control group(51.47%)(P<0.01).The severity of pressure ulcer in intervention group was lighter than that in control group(P<0.05).Conclusions: The application of the predictive nursing can effectively decrease the incidence rate and severity of pressure ulcers.
2016, 41(12): 1691-1694.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.050
Abstract:
Objective: To explore the effects of continuous care intervention based on Omaha system on the quality of life of patients with permanent bladder fistula.Methods: Sixty-eight patients with permanent bladder fistula were chosen.The nursing problem was assessed according to Omaha system,and the intervention measures were formulated.The invention effects were analyzed.Results: The nursing problems of patients in the first stage mainly included pain(91.2%),urinary function(100.0%),sleep(88.2%) and mental health(70.6%).The nursing problems of patients in the second stage mainly included skin(69.1%),urinary function(100.0%),infection(76.5%),substance abuse(82.4%) and interpersonal relationship(97.1%).The nursing problems of patients about cognition,behavior and condition were significantly improved after the targeted nursing invention(P<0.01).Conclusions: The continuous care intervention based on Omaha System can effectively improve the nursing effect and quality of life of patients with permanent bladder fistula.
Objective: To explore the effects of continuous care intervention based on Omaha system on the quality of life of patients with permanent bladder fistula.Methods: Sixty-eight patients with permanent bladder fistula were chosen.The nursing problem was assessed according to Omaha system,and the intervention measures were formulated.The invention effects were analyzed.Results: The nursing problems of patients in the first stage mainly included pain(91.2%),urinary function(100.0%),sleep(88.2%) and mental health(70.6%).The nursing problems of patients in the second stage mainly included skin(69.1%),urinary function(100.0%),infection(76.5%),substance abuse(82.4%) and interpersonal relationship(97.1%).The nursing problems of patients about cognition,behavior and condition were significantly improved after the targeted nursing invention(P<0.01).Conclusions: The continuous care intervention based on Omaha System can effectively improve the nursing effect and quality of life of patients with permanent bladder fistula.
2016, 41(12): 1694-1696.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.051
Abstract:
Objective: To investigate the postoperative psychological status of patients with femoral condyle fracture,and propose the corresponding nursing intervention measures.Methods: Fifty-six patients with femoral condyle fractures were investigated by SCL-90.The postoperative psychological status and influence factors of patients were analyzed,and the corresponding nursing intervention measure was proposed.Results: The negatively psychological emotion in patients with femoral condyle fractures were obviously found.The total score of SCL-90 in patients was(1.57±0.43),which was higher than that in normal people(1.44±0.43)(P<0.05).The gender,age,marital status and AO type were the main influencing factors of postoperative psychological status of patients with femoral condyle fracture(P<0.05).Conclusions: Patients with femoral condyle fracture has commonly negative psychology.The medical institution should formulate the nursing intervention measure according to the individual difference to improve the psychological status and enhance the quality of life of patients.
Objective: To investigate the postoperative psychological status of patients with femoral condyle fracture,and propose the corresponding nursing intervention measures.Methods: Fifty-six patients with femoral condyle fractures were investigated by SCL-90.The postoperative psychological status and influence factors of patients were analyzed,and the corresponding nursing intervention measure was proposed.Results: The negatively psychological emotion in patients with femoral condyle fractures were obviously found.The total score of SCL-90 in patients was(1.57±0.43),which was higher than that in normal people(1.44±0.43)(P<0.05).The gender,age,marital status and AO type were the main influencing factors of postoperative psychological status of patients with femoral condyle fracture(P<0.05).Conclusions: Patients with femoral condyle fracture has commonly negative psychology.The medical institution should formulate the nursing intervention measure according to the individual difference to improve the psychological status and enhance the quality of life of patients.
2016, 41(12): 1697-1699.
doi: 10.13898/j.cnki.issn.1000-2200.2016.12.052
Abstract:
Objective: To explore the effects of the cognitive behavior intervention combined with preventive nursing on patients with coronary heart disease.Methods: One hundred and twenty patients with coronary heart disease were randomly divided into the control group(n=60) and observation group(n=60).The control group were nursed with routine method,and the observation group were nursed with the cognitive behavior intervention combined with preventive nursing based on the routine measure.The scores of the HAMA,HAMD and ADL before and after treatment,patients with hypertension and abnormal heart rate,hospitalization time and cost in two groups were observed and recorded.Results: Before treatment,the difference of the clinical index between two groups was not statistically significant(P>0.05).After treatment the scores of HAMA,HAMD and ADL in two groups were significantly improved(P<0.01),the patient with hypertension and abnormal heart rate decreased(P<0.05),and the scores of HAMA,HAMD and ADL in observation group were significantly better than those in control group(P<0.01).Compared with the control group,the hospitalization time and costs in observation group were significantly shorter and lower(P<0.01).Conclusions: The cognitive behavior intervention combined with preventive nursing can obviously alleviate the anxiety and depression,improve the quality of life and clinical treatment and nursing effects in patients with coronary heart disease.
Objective: To explore the effects of the cognitive behavior intervention combined with preventive nursing on patients with coronary heart disease.Methods: One hundred and twenty patients with coronary heart disease were randomly divided into the control group(n=60) and observation group(n=60).The control group were nursed with routine method,and the observation group were nursed with the cognitive behavior intervention combined with preventive nursing based on the routine measure.The scores of the HAMA,HAMD and ADL before and after treatment,patients with hypertension and abnormal heart rate,hospitalization time and cost in two groups were observed and recorded.Results: Before treatment,the difference of the clinical index between two groups was not statistically significant(P>0.05).After treatment the scores of HAMA,HAMD and ADL in two groups were significantly improved(P<0.01),the patient with hypertension and abnormal heart rate decreased(P<0.05),and the scores of HAMA,HAMD and ADL in observation group were significantly better than those in control group(P<0.01).Compared with the control group,the hospitalization time and costs in observation group were significantly shorter and lower(P<0.01).Conclusions: The cognitive behavior intervention combined with preventive nursing can obviously alleviate the anxiety and depression,improve the quality of life and clinical treatment and nursing effects in patients with coronary heart disease.
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