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2016 Vol. 41, No. 2
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2016, 41(2): 141-144.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.001
Abstract:
Objective: To Study on the pathological lesion in Balb/c mice infected with H37Ra. Methods: The mice were divided into control group and model group infected with Mycobacterium tuberculosis. Balb/c mice was injected via the tail vein with attenuated Mycobacterium tuberculosis H37Ra (1×106 CFU/mouse). After infection, living bacteria, organ weight index of lung or spleen, and histopathological lesion were detected after 7, 14, and 21 days of infection. Results: Compared with the group of control, the organ coefficient of spleen increased statistically after 14 days or 21 days of infection(P<0.01 and P<0.05);The number of living bacteria in spleen tissue of infected mice increased with the days of infection and was higher in spleen tissue than that in lung tissue. Tuberculosis-like lesions were observed in spleen and lung tissue of infected mice model. Conclusions: Attenuated Mycobacterium tuberculosis H37Ra could induced tuberculosis-like lesions in Balb/c mouse via the tail vein injection.
Objective: To Study on the pathological lesion in Balb/c mice infected with H37Ra. Methods: The mice were divided into control group and model group infected with Mycobacterium tuberculosis. Balb/c mice was injected via the tail vein with attenuated Mycobacterium tuberculosis H37Ra (1×106 CFU/mouse). After infection, living bacteria, organ weight index of lung or spleen, and histopathological lesion were detected after 7, 14, and 21 days of infection. Results: Compared with the group of control, the organ coefficient of spleen increased statistically after 14 days or 21 days of infection(P<0.01 and P<0.05);The number of living bacteria in spleen tissue of infected mice increased with the days of infection and was higher in spleen tissue than that in lung tissue. Tuberculosis-like lesions were observed in spleen and lung tissue of infected mice model. Conclusions: Attenuated Mycobacterium tuberculosis H37Ra could induced tuberculosis-like lesions in Balb/c mouse via the tail vein injection.
2016, 41(2): 145-147.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.002
Abstract:
Objective: To locate and analyze the morphology features of the hand motor cortex. Methods: The brains of 48 right-handed healthy people were scanned using MRI. The MRI imagings of transection plane, sagittal plane, coronal plane from 96 cerebral hemispheres were collected, which was used to identify, locate and analyze the morphology features of the hand motor cortex. Results: The hand motor cortex were classified into the inverted omega, omega, medially nonsymmetric omega, laterally nonsymmetric omega, curve, clover and wave types. The differences of the constituent ratio of various types between male and female, and between bilateral cerebral hemispheres of male and female were not statistically significant(P>0.05). The width of the inverted omega type in male was significantly more than that in female(P<0.01). Conclusions: Improving the procentral knob motor cortex typing can provide the basis in identifing precentral gyrus.
Objective: To locate and analyze the morphology features of the hand motor cortex. Methods: The brains of 48 right-handed healthy people were scanned using MRI. The MRI imagings of transection plane, sagittal plane, coronal plane from 96 cerebral hemispheres were collected, which was used to identify, locate and analyze the morphology features of the hand motor cortex. Results: The hand motor cortex were classified into the inverted omega, omega, medially nonsymmetric omega, laterally nonsymmetric omega, curve, clover and wave types. The differences of the constituent ratio of various types between male and female, and between bilateral cerebral hemispheres of male and female were not statistically significant(P>0.05). The width of the inverted omega type in male was significantly more than that in female(P<0.01). Conclusions: Improving the procentral knob motor cortex typing can provide the basis in identifing precentral gyrus.
2016, 41(2): 148-151.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.003
Abstract:
Objective: To investigate the effects of fasudil on left ventricular hypertrophy in rats with pressure overload, and its possible mechanism. Methods: Pressure overload model in 42 male 6-week-old SD rats were established by abdominal aorta constriction, and divided into the operation group. Eight healthy rats were set as sham group. Twenty-eight survival abdominal aorta constriction rats after 4 weeks of operation were randomly divided into the model group, high dose fasudil group(FH group) and low dose fasudil group(FL group). After four weeks of drug intervention, the left ventricular mass indexes(LVMI) of all groups were calculated. The myocardial pathological changes were observed. The myocyte diameters(MD) were detected. Myocardial hydroxyproline(HYP) contents were determinated by alkali hydrolysis. Plasma and myocardial AngⅡ concentrations were detected by enzyme linked immunosorbent assay. Myocardial expression levels of phosphorylated myosin phosphatase targeting protein subunit 1(p-MYPT1), matrix metalloproteinase 9(MMP9) and tissue inhibitor of metalloproteinase 1(TIMP1) were analyzed by immunohistochemical staining. Results: Compared with the sham group, myocardial cells hypertrophy and collagen deposition in myocardial interstitium were found, the levels of LVMI, MD, HYP, AngⅡ, p-MYPT1, MMP9 and TIMP1 increased significantly, and the ratio of MMP9/TIMP1 decreased significantly in model group(P<0.01). Compared with the model group, myocardial cells hypertrophy and collagen deposition were improved, and the levels of LVMI, MD, HYP, Ang Ⅱ, p-MYPT1, MMP9, TIMP1 decreased significantly in FH group and FL group(P<0.05 to P<0.01). Conclusions: Fasudil improving left ventricular hypertrophy in pressure overload rats maybe related to the regulating myocardial MMP9 and TIMP1 expression levels
Objective: To investigate the effects of fasudil on left ventricular hypertrophy in rats with pressure overload, and its possible mechanism. Methods: Pressure overload model in 42 male 6-week-old SD rats were established by abdominal aorta constriction, and divided into the operation group. Eight healthy rats were set as sham group. Twenty-eight survival abdominal aorta constriction rats after 4 weeks of operation were randomly divided into the model group, high dose fasudil group(FH group) and low dose fasudil group(FL group). After four weeks of drug intervention, the left ventricular mass indexes(LVMI) of all groups were calculated. The myocardial pathological changes were observed. The myocyte diameters(MD) were detected. Myocardial hydroxyproline(HYP) contents were determinated by alkali hydrolysis. Plasma and myocardial AngⅡ concentrations were detected by enzyme linked immunosorbent assay. Myocardial expression levels of phosphorylated myosin phosphatase targeting protein subunit 1(p-MYPT1), matrix metalloproteinase 9(MMP9) and tissue inhibitor of metalloproteinase 1(TIMP1) were analyzed by immunohistochemical staining. Results: Compared with the sham group, myocardial cells hypertrophy and collagen deposition in myocardial interstitium were found, the levels of LVMI, MD, HYP, AngⅡ, p-MYPT1, MMP9 and TIMP1 increased significantly, and the ratio of MMP9/TIMP1 decreased significantly in model group(P<0.01). Compared with the model group, myocardial cells hypertrophy and collagen deposition were improved, and the levels of LVMI, MD, HYP, Ang Ⅱ, p-MYPT1, MMP9, TIMP1 decreased significantly in FH group and FL group(P<0.05 to P<0.01). Conclusions: Fasudil improving left ventricular hypertrophy in pressure overload rats maybe related to the regulating myocardial MMP9 and TIMP1 expression levels
2016, 41(2): 152-154,158.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.004
Abstract:
Objective: To investigate the association of indel polymorphisms of BRM-741 and BRM-132 with the susceptibility of esophageal squamous cell carcinoma (ESCC) in Chinese Han population. Methods: The genotype distribution of BRM-741and BRM-1321 in 343cases of ESCC and 362 healthy controls whose gender, age and other demographic characteristics were matched with the frequency of the ESCC cases was analyzed in a case-control study by using polymerase chain reaction-polyacrylamide gel electrophoresis method. Logistic regression model was used to evaluate the association between polymorphisms and ESCC susceptibility. Results: There was no significant association between BRM-741 and ESCC(P>0.05). However, there was a significant association between BRM-1321 and ESCC susceptibility(P<0.01). The insertion/insertion genotype was associated with an increased risk of ESCC compared with the deletion/deletion genotype of BRM 1321 (OR=1.94, 95%CI=1.11-3.38). The insertion allel was associated with an increased risk of ESCC compared with the deletion allel of BRM 1321 (OR=1.35, 95%CI=1.07-1.71). Conclusions: The polymorphism in BRM-1321 is associated with ESCC susceptibility, but no significant association is observed between the polymorphism in BRM-741 and ESCC incidence in Chinese Han population.
Objective: To investigate the association of indel polymorphisms of BRM-741 and BRM-132 with the susceptibility of esophageal squamous cell carcinoma (ESCC) in Chinese Han population. Methods: The genotype distribution of BRM-741and BRM-1321 in 343cases of ESCC and 362 healthy controls whose gender, age and other demographic characteristics were matched with the frequency of the ESCC cases was analyzed in a case-control study by using polymerase chain reaction-polyacrylamide gel electrophoresis method. Logistic regression model was used to evaluate the association between polymorphisms and ESCC susceptibility. Results: There was no significant association between BRM-741 and ESCC(P>0.05). However, there was a significant association between BRM-1321 and ESCC susceptibility(P<0.01). The insertion/insertion genotype was associated with an increased risk of ESCC compared with the deletion/deletion genotype of BRM 1321 (OR=1.94, 95%CI=1.11-3.38). The insertion allel was associated with an increased risk of ESCC compared with the deletion allel of BRM 1321 (OR=1.35, 95%CI=1.07-1.71). Conclusions: The polymorphism in BRM-1321 is associated with ESCC susceptibility, but no significant association is observed between the polymorphism in BRM-741 and ESCC incidence in Chinese Han population.
2016, 41(2): 155-158.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.005
Abstract:
Objective: To investigate the mechanism of cells apoptosis in rabbit with acute lung injury(ALI) induced by blast. Methods: Forty rabbits were randomly divided into the control group(n=10) and experimental group(n=30). The ALI model of rabbit was established by air blast. After 4, 12 and 24 hours of lung injury, the cells apoptosis of injury tissue were detected using the wet/dry weight ratio(W/D) of lung, PaO2 and TUNEL, the levels of caspase-3, Bax and Bcl-2 were detected using immunohistochemistry and the pathological morphology were observed under microscopy in 10 rabbits each time-point. Results: The pulmonary interstitial and alveolar edema, a large number of red blood cells, inflammatory cells and serous effusion in alveolar space, and pulmonary interstitial thickening were found in experimental group under light microscope. Compared with the control group, the W/D and PaO2 in experimental group increased and decreased significantly, respectively(P<0.01), The apoptosis index, caspase-3 and Bax/Bcl-2 in experimental group were significantly higher than those in control group(P<0.05 to P<0.01). Conclusions: Apoptosis plays an important role in the occurrence and development of ALI, which is involved in lung tissue injury and promoting the development of ALI.
Objective: To investigate the mechanism of cells apoptosis in rabbit with acute lung injury(ALI) induced by blast. Methods: Forty rabbits were randomly divided into the control group(n=10) and experimental group(n=30). The ALI model of rabbit was established by air blast. After 4, 12 and 24 hours of lung injury, the cells apoptosis of injury tissue were detected using the wet/dry weight ratio(W/D) of lung, PaO2 and TUNEL, the levels of caspase-3, Bax and Bcl-2 were detected using immunohistochemistry and the pathological morphology were observed under microscopy in 10 rabbits each time-point. Results: The pulmonary interstitial and alveolar edema, a large number of red blood cells, inflammatory cells and serous effusion in alveolar space, and pulmonary interstitial thickening were found in experimental group under light microscope. Compared with the control group, the W/D and PaO2 in experimental group increased and decreased significantly, respectively(P<0.01), The apoptosis index, caspase-3 and Bax/Bcl-2 in experimental group were significantly higher than those in control group(P<0.05 to P<0.01). Conclusions: Apoptosis plays an important role in the occurrence and development of ALI, which is involved in lung tissue injury and promoting the development of ALI.
2016, 41(2): 159-160,163.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.006
Abstract:
Objective: To investigate the related factors influencing the prognosis of patients with paraquat(PQ) poisoning. Methods: Eighty-nine patients with acute PQ were divided into the survival group(48 cases) and death group(41 cases) according to the prognosis of disease. The relationship between gender, age, plasma PQ concentration, WBC count, BUN, Scr, ALT, AST, CKMB and K+ and the prognosis of PQ patients were analyzed. Results: The plasma PQ concentration, WBC count, Scr, BUN, ALT, CKMB and AST in death group were higher than those in survival group, but the plasma level of K+ in death group was lower than that in survival group(P<0.05 to P<0.01). Conclusions: Plasma PQ concentration is the key influencing prognosis factor in PQ patients, meanwhile, the WBC, Scr, ALT, CKMB, AST and plasma level of K+ affect also the prognosis of PQ patients.
Objective: To investigate the related factors influencing the prognosis of patients with paraquat(PQ) poisoning. Methods: Eighty-nine patients with acute PQ were divided into the survival group(48 cases) and death group(41 cases) according to the prognosis of disease. The relationship between gender, age, plasma PQ concentration, WBC count, BUN, Scr, ALT, AST, CKMB and K+ and the prognosis of PQ patients were analyzed. Results: The plasma PQ concentration, WBC count, Scr, BUN, ALT, CKMB and AST in death group were higher than those in survival group, but the plasma level of K+ in death group was lower than that in survival group(P<0.05 to P<0.01). Conclusions: Plasma PQ concentration is the key influencing prognosis factor in PQ patients, meanwhile, the WBC, Scr, ALT, CKMB, AST and plasma level of K+ affect also the prognosis of PQ patients.
2016, 41(2): 161-163.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.007
Abstract:
Objective: To investigate the application value of furosemide guided by lung ultrasound in the treatment of acute left heart failure. Methods: Seventy patients with acute left heart failure were randomly divided into the observation group(36 cases) and control group(34 cases). The control group were empirically treated with furosemide, the observation group were treated with furosemide guided by lung ultrasound. The total required diuretics, maximum daily urine amount and the decreasing degree of B-type natriuretic peptide after treatment between two group were compared. Results: The total required furosemide in observation group was less than that in control group(P<0.01). The differences of maximum daily urine amount and the decreasing degree of B-type natriuretic peptide after treatment in two groups were statistically significant(P<0.01). Conclusions: Lung ultrasound can evaluate the therapeutic effects of furosemide in patients with acute left heart failure, guide the treatment of acute left heart failure, and reduce the use amount of furosemide.
Objective: To investigate the application value of furosemide guided by lung ultrasound in the treatment of acute left heart failure. Methods: Seventy patients with acute left heart failure were randomly divided into the observation group(36 cases) and control group(34 cases). The control group were empirically treated with furosemide, the observation group were treated with furosemide guided by lung ultrasound. The total required diuretics, maximum daily urine amount and the decreasing degree of B-type natriuretic peptide after treatment between two group were compared. Results: The total required furosemide in observation group was less than that in control group(P<0.01). The differences of maximum daily urine amount and the decreasing degree of B-type natriuretic peptide after treatment in two groups were statistically significant(P<0.01). Conclusions: Lung ultrasound can evaluate the therapeutic effects of furosemide in patients with acute left heart failure, guide the treatment of acute left heart failure, and reduce the use amount of furosemide.
2016, 41(2): 164-167.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.008
Abstract:
Objective: To summarize the common pathogenic bacteria and drug resistance of neonatal sepsis. Methods: The blood culture and sensitivity results of 96 cases of neonatal sepsis were analyzed retrospectively. Results: Ninety-seven strains of pathogenic bacteria were detected from the 96 cases of blood specimen, which included 74 strains of Gram-positive bacteria, 19 strains of Gram-negative and 4 strains of fungus. Gram-positive bacteria were highly resistant to penicillin, but completely sensitive to vancomycin;Gram negative bacteria were highly resistant to cephalosporin but not so resistant to meropenem;no bacterial strains were resistant to amikacin. Conclusions: The main pathogens of neonatal sepsis are Gram-positive coccio which are highly resistant to penicillins and cephalosporins.
Objective: To summarize the common pathogenic bacteria and drug resistance of neonatal sepsis. Methods: The blood culture and sensitivity results of 96 cases of neonatal sepsis were analyzed retrospectively. Results: Ninety-seven strains of pathogenic bacteria were detected from the 96 cases of blood specimen, which included 74 strains of Gram-positive bacteria, 19 strains of Gram-negative and 4 strains of fungus. Gram-positive bacteria were highly resistant to penicillin, but completely sensitive to vancomycin;Gram negative bacteria were highly resistant to cephalosporin but not so resistant to meropenem;no bacterial strains were resistant to amikacin. Conclusions: The main pathogens of neonatal sepsis are Gram-positive coccio which are highly resistant to penicillins and cephalosporins.
2016, 41(2): 167-168.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.009
Abstract:
Objective: To investigate the effects of orbital fat preservation and reset in the repair of lower eyelid pouch. Methods: Thirty patients with lower eyelid pouches were treated with orbital fat preservation and reset. All cases were followed up for 6 to 36 months after operation. The sunken eyelid, eyelid-cheek complex contour and patient satisfaction were evaluated. Results: Treatment of 30 cases were satisfactory. No "unsatisfactory" evaluation, no sunken eyelid and full contour of eyelid-cheek complex were found. Conclusions: The effects of orbital fat preservation and reset in the younger repair of eyelid pouch are good, which is benefit to the repair of different types of eyelid-cheeked complex contour, and worthy of promotion.
Objective: To investigate the effects of orbital fat preservation and reset in the repair of lower eyelid pouch. Methods: Thirty patients with lower eyelid pouches were treated with orbital fat preservation and reset. All cases were followed up for 6 to 36 months after operation. The sunken eyelid, eyelid-cheek complex contour and patient satisfaction were evaluated. Results: Treatment of 30 cases were satisfactory. No "unsatisfactory" evaluation, no sunken eyelid and full contour of eyelid-cheek complex were found. Conclusions: The effects of orbital fat preservation and reset in the younger repair of eyelid pouch are good, which is benefit to the repair of different types of eyelid-cheeked complex contour, and worthy of promotion.
2016, 41(2): 169-172.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.010
Abstract:
Objective: To analyzed the long-term clinical effects of the short-segment pedicle screw internal fixation in the treatment of single-level thoracolumbar bursting fracture. Methods: Forty-six cases with single-level thoracolumbar bursting fracture were treated with short-segment pedicle screw(four screws two rods) internal fixation. The internal fixations were removed at 12 months after operation. All cases were followed up for 18 to 36 months. Results: Compared before operation, the anterior height of vertebral body recovered immediately after operation(P<0.01), the Kyphosis after operation was improved significantly(P<0.01). Screw position and stability were good, no aggravation of spinal cord neurological symptom was found. During the following-up period, the internal fixation fracture in 6 cases were identified. Compared immediately after operation, the anterior height of vertebral body decreased at the end of the following-up(P<0.01). The P1W1 in 9 cases(25%), P2W2 in 26 cases, P3W2 in 7 cases and P3W3 in 4 cases were found according to the Denis pain score. Conclusions: The short-segment pedicle screw internal fixation in the treatment of single-level thoracolumbar bursting fracture has some complications, the long-term effect of which is difficult to maintain, and its clinical application should be cautious.
Objective: To analyzed the long-term clinical effects of the short-segment pedicle screw internal fixation in the treatment of single-level thoracolumbar bursting fracture. Methods: Forty-six cases with single-level thoracolumbar bursting fracture were treated with short-segment pedicle screw(four screws two rods) internal fixation. The internal fixations were removed at 12 months after operation. All cases were followed up for 18 to 36 months. Results: Compared before operation, the anterior height of vertebral body recovered immediately after operation(P<0.01), the Kyphosis after operation was improved significantly(P<0.01). Screw position and stability were good, no aggravation of spinal cord neurological symptom was found. During the following-up period, the internal fixation fracture in 6 cases were identified. Compared immediately after operation, the anterior height of vertebral body decreased at the end of the following-up(P<0.01). The P1W1 in 9 cases(25%), P2W2 in 26 cases, P3W2 in 7 cases and P3W3 in 4 cases were found according to the Denis pain score. Conclusions: The short-segment pedicle screw internal fixation in the treatment of single-level thoracolumbar bursting fracture has some complications, the long-term effect of which is difficult to maintain, and its clinical application should be cautious.
2016, 41(2): 172-174.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.011
Abstract:
Objective: To investigate the incidence of thyroid nodules in elderly patients with type 2 diabetic. Methods: The fasting blood-glucose, glycosylated hemoglobin and high-resolution ultrasonography of 528 elderly patients with type 2 diabetes (T2DM group) and 312 healthy controls (control group) were detected and compared. Results: The total prevalence rate of thyroid nodules was 57.58% in the T2DM group, which was higher than that of the control group (45.83%)(P<0.01);and multiple nodules were most often seen. The incidence of thyroid nodules in the group over 70 was higher than that in the group over 50 in both the male and the female(P<0.05), while there was no statistical significance in different diabetic periods(P>0.05). Thyroid nodules were more commonly seen in the female (63.30%) than in the male (50.22%)(P<0.01);The prevalence rate of thyroid nodules demonstrated that there was no statistical significance between patients with glycosylated hemoglobin < 7% and ≥ 7% (P>0.05). Logistic regression analysis showed that age, gender and diabetes were independent risk factors for thyroid nodules. Conclusions: The incidence of thyroid nodules is higher in elderly patients with type 2 diabetic than in the normal control. As the disease may affect the prognosis and treatment of T2DM, special attention and screening should be directed to those patients.
Objective: To investigate the incidence of thyroid nodules in elderly patients with type 2 diabetic. Methods: The fasting blood-glucose, glycosylated hemoglobin and high-resolution ultrasonography of 528 elderly patients with type 2 diabetes (T2DM group) and 312 healthy controls (control group) were detected and compared. Results: The total prevalence rate of thyroid nodules was 57.58% in the T2DM group, which was higher than that of the control group (45.83%)(P<0.01);and multiple nodules were most often seen. The incidence of thyroid nodules in the group over 70 was higher than that in the group over 50 in both the male and the female(P<0.05), while there was no statistical significance in different diabetic periods(P>0.05). Thyroid nodules were more commonly seen in the female (63.30%) than in the male (50.22%)(P<0.01);The prevalence rate of thyroid nodules demonstrated that there was no statistical significance between patients with glycosylated hemoglobin < 7% and ≥ 7% (P>0.05). Logistic regression analysis showed that age, gender and diabetes were independent risk factors for thyroid nodules. Conclusions: The incidence of thyroid nodules is higher in elderly patients with type 2 diabetic than in the normal control. As the disease may affect the prognosis and treatment of T2DM, special attention and screening should be directed to those patients.
2016, 41(2): 175-177.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.012
Abstract:
Objective: To study the effect of azithromycin on immune function of children with mycoplasma pneumoniae pneumonia. Methods: One hundred and ten children with mycoplasma pneumoniae pneumonia were randomly divided into observation group and control group(n=55) according to the digital table method. Children in observation group were given azithromycin at 10 mg·kg-1·d-1 intravenously, and children in control group were given erythromycin at 20~30 mg·kg-1·d-1, 7 d for 1 course of treatment. The 2nd day, the curative effect, peripheral serum IgA, IgG, IgM levels and the changes of T lymphocyte subsets were compared in the two groups. Results: The total effective rate was 94.55% in observation group, which was higher than 81.82% in control group (P<0.05). After treatment, peripheral serum IgA, IgG and IgM levels in the two groups were significantly lower than before treatment (P<0.01), peripheral serum IgA, IgG and IgM levels in observation group were significantly lower than in control group (P<0.01);Peripheral blood CD4+ content, natural killer cell content and the ratio of CD4+/CD8+ were significantly reduced, CD8+ content was increased significantly after treatment in the two groups (P<0.01). After treatment, in observation group, peripheral blood CD4+ content, natural killer cell content and the ratio of CD4+/CD8+ were significantly lower while CD8+ content was obviously higher than in control group (P<0.01). Conclusions: The curative effect of azithromycin on mycoplasma pneumoniae pneumonia is notable, which is better than that of erythromycin. Azithromycin and erythromycin both can adjust the immune function of organism effectively, but the role of azithromycin regulate the body's immune function is more obvious.
Objective: To study the effect of azithromycin on immune function of children with mycoplasma pneumoniae pneumonia. Methods: One hundred and ten children with mycoplasma pneumoniae pneumonia were randomly divided into observation group and control group(n=55) according to the digital table method. Children in observation group were given azithromycin at 10 mg·kg-1·d-1 intravenously, and children in control group were given erythromycin at 20~30 mg·kg-1·d-1, 7 d for 1 course of treatment. The 2nd day, the curative effect, peripheral serum IgA, IgG, IgM levels and the changes of T lymphocyte subsets were compared in the two groups. Results: The total effective rate was 94.55% in observation group, which was higher than 81.82% in control group (P<0.05). After treatment, peripheral serum IgA, IgG and IgM levels in the two groups were significantly lower than before treatment (P<0.01), peripheral serum IgA, IgG and IgM levels in observation group were significantly lower than in control group (P<0.01);Peripheral blood CD4+ content, natural killer cell content and the ratio of CD4+/CD8+ were significantly reduced, CD8+ content was increased significantly after treatment in the two groups (P<0.01). After treatment, in observation group, peripheral blood CD4+ content, natural killer cell content and the ratio of CD4+/CD8+ were significantly lower while CD8+ content was obviously higher than in control group (P<0.01). Conclusions: The curative effect of azithromycin on mycoplasma pneumoniae pneumonia is notable, which is better than that of erythromycin. Azithromycin and erythromycin both can adjust the immune function of organism effectively, but the role of azithromycin regulate the body's immune function is more obvious.
2016, 41(2): 178-180,184.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.013
Abstract:
Objective: To evaluate the clinical efficacy of high dose adenosine through percutaneous coronary intervention in the treatment of the acute ST segment elevation myocardial infarction. Methods: Eighty-two patients with acute ST segment elevation myocardial infarction were randomly divided into the study group and control group(42 cases each group). All patients were treated with percutaneous coronary intervention(PCI). The study group and control group were treated with 600 μg of adenosine combined with 10 mL of saline and 300 μg of adenosine combined with 10 mL of saline for 1 min, respectively, then two groups were additionally treated with stenting. Coronary flow of infarction related artery(IRA) was assessed after treatment. The serum levels of creatine kinase, isoenzyme of creatine kinase and cardiac troponin I, drop rate of ST segment elevation and left ventricular ejection fraction between two groups were compared after operation. Results: The biochemical and ECG indexes in study group were significantly better than those in control group after treatment(P<0.05 to P<0.01). The difference of TIMI rating between two groups before operation and after 30 min of operation was not statistically significant(P>0.05). The TIMI rating in study group at the end of operation was better than that in control group(P<0.05). The differences of the incidence of postoperative adverse reactions and serious cardiovascular events after 30 days of operation between two groups were not statistically significant(P>0.05). Conclusions: The treatment of the acute ST segment elevation myocardial infarction with the high dose of adenosine through percutaneous coronary intervention is safe and effective, which has certain application value.
Objective: To evaluate the clinical efficacy of high dose adenosine through percutaneous coronary intervention in the treatment of the acute ST segment elevation myocardial infarction. Methods: Eighty-two patients with acute ST segment elevation myocardial infarction were randomly divided into the study group and control group(42 cases each group). All patients were treated with percutaneous coronary intervention(PCI). The study group and control group were treated with 600 μg of adenosine combined with 10 mL of saline and 300 μg of adenosine combined with 10 mL of saline for 1 min, respectively, then two groups were additionally treated with stenting. Coronary flow of infarction related artery(IRA) was assessed after treatment. The serum levels of creatine kinase, isoenzyme of creatine kinase and cardiac troponin I, drop rate of ST segment elevation and left ventricular ejection fraction between two groups were compared after operation. Results: The biochemical and ECG indexes in study group were significantly better than those in control group after treatment(P<0.05 to P<0.01). The difference of TIMI rating between two groups before operation and after 30 min of operation was not statistically significant(P>0.05). The TIMI rating in study group at the end of operation was better than that in control group(P<0.05). The differences of the incidence of postoperative adverse reactions and serious cardiovascular events after 30 days of operation between two groups were not statistically significant(P>0.05). Conclusions: The treatment of the acute ST segment elevation myocardial infarction with the high dose of adenosine through percutaneous coronary intervention is safe and effective, which has certain application value.
2016, 41(2): 181-184.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.014
Abstract:
Objective: To investigate the clinical effects of the closed reduction and plaster fixation combined with percutaneous pinning in the treatment of elderly distal radial fractures. Methods: Thirty-six elderly patients with distal radial fractures were treated with the closed reduction and plaster fixation combined with percutaneous pinning. Results: All cases were followed up for 2 to 6 months. All fractures healed. According to Gartland-Werley scoring system, excellent in 20 cases, good in 13 cases and fair in 3 cases were identified, and the excellent and good rate was 91.7%. According to Cooney scoring system, excellent in 19 cases, good in 12 cases and poor in 1 case were identified, and the excellent and good rate was 86.1%. Conclusions: The treatment of elderly distal radial fractures with the closed reduction and plaster fixation combined with percutaneous pinning is effective, little trauma and less cost.
Objective: To investigate the clinical effects of the closed reduction and plaster fixation combined with percutaneous pinning in the treatment of elderly distal radial fractures. Methods: Thirty-six elderly patients with distal radial fractures were treated with the closed reduction and plaster fixation combined with percutaneous pinning. Results: All cases were followed up for 2 to 6 months. All fractures healed. According to Gartland-Werley scoring system, excellent in 20 cases, good in 13 cases and fair in 3 cases were identified, and the excellent and good rate was 91.7%. According to Cooney scoring system, excellent in 19 cases, good in 12 cases and poor in 1 case were identified, and the excellent and good rate was 86.1%. Conclusions: The treatment of elderly distal radial fractures with the closed reduction and plaster fixation combined with percutaneous pinning is effective, little trauma and less cost.
2016, 41(2): 185-187,190.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.015
Abstract:
Objective: To analyze the relationship between U wave inversion and coronary lesions in patients with acute coronary syndrome. Methods: Eighty-six ACS patients diagnosed by coronary angiography were divided into the U wave inversion group and non-U wave inversion group according to the U wave of electrocardiogram. The index of different coronary artery lesions between the two groups were compared. Results: The U wave inversion in 38 cases and non-U wave inversion in 48 cases were identified. The incidence of UA and ST segment elevation myocardial infarction in non-U wave inversion group were significantly more and less than those in U wave inversion group, respectively(P<0.01). Compared with non-U wave inversion group, the value of E/A and LVEF in U wave inversion group decreased(P<0.01). U wave inversion group was mainly characterized by moderate and severe stenosis, no obvious lesion and mild stenosis in non-U wave inversion group were identified, and the differences of those were statistically significant(P<0.01). The difference of the surface morphology of coronary lesions between two groups was statistically significant(P<0.01). The incidence in left main(LM) and left anterior descending(LAD) in U wave inversion group were higher than those in non-U wave inversion group(P<0.01), and the differences of the incidence of left circumflex and right coronary artery(RCA) between two groups were not statistically significant(P>0.05). The differences of the incidence of the single, double and three lesions vessels between two groups were statistically significant(P<0.01). The differences of the incidence of U wave inversion depth, coronary lesion vessels and degree of stenosis between two groups were statistically significant(P<0.01), the difference of the surface morphology of coronary lesions between two groups was not statistically significant(P>0.01). Conclusions: ECG U wave inversion in patients with ACS can effectively reflect the severity of coronary lesions.
Objective: To analyze the relationship between U wave inversion and coronary lesions in patients with acute coronary syndrome. Methods: Eighty-six ACS patients diagnosed by coronary angiography were divided into the U wave inversion group and non-U wave inversion group according to the U wave of electrocardiogram. The index of different coronary artery lesions between the two groups were compared. Results: The U wave inversion in 38 cases and non-U wave inversion in 48 cases were identified. The incidence of UA and ST segment elevation myocardial infarction in non-U wave inversion group were significantly more and less than those in U wave inversion group, respectively(P<0.01). Compared with non-U wave inversion group, the value of E/A and LVEF in U wave inversion group decreased(P<0.01). U wave inversion group was mainly characterized by moderate and severe stenosis, no obvious lesion and mild stenosis in non-U wave inversion group were identified, and the differences of those were statistically significant(P<0.01). The difference of the surface morphology of coronary lesions between two groups was statistically significant(P<0.01). The incidence in left main(LM) and left anterior descending(LAD) in U wave inversion group were higher than those in non-U wave inversion group(P<0.01), and the differences of the incidence of left circumflex and right coronary artery(RCA) between two groups were not statistically significant(P>0.05). The differences of the incidence of the single, double and three lesions vessels between two groups were statistically significant(P<0.01). The differences of the incidence of U wave inversion depth, coronary lesion vessels and degree of stenosis between two groups were statistically significant(P<0.01), the difference of the surface morphology of coronary lesions between two groups was not statistically significant(P>0.01). Conclusions: ECG U wave inversion in patients with ACS can effectively reflect the severity of coronary lesions.
2016, 41(2): 188-190.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.016
Abstract:
Objective: To investigate the effects of hyperbaric oxygen(HBO) on the postoperative cerebral edema in patients with meningiomas. Methods: Fifty-four patients with meningiomas were divided into the observation group and control group(27 cases each group). All patients were treated with the conventional method after operation, and the observation group were additionally treated with HBO. The cerebral edema and neurologic function recovery between two groups were compared. Results: After treatment, the volume of cerebral edema and decreased degree of neurologic impairment score in observation group were obviously more than those in control group(P<0.01). The increased degree of Barthe I index in observation group was significantly higher than that in control group(P<0.01). The difference of the recurrence rate between two group was not statistically significant(P>0.05). Conclusions: The postoperative treatment of meningiomas with HBO can promote the fade away of cerebral edema, and improve the neurologic function.
Objective: To investigate the effects of hyperbaric oxygen(HBO) on the postoperative cerebral edema in patients with meningiomas. Methods: Fifty-four patients with meningiomas were divided into the observation group and control group(27 cases each group). All patients were treated with the conventional method after operation, and the observation group were additionally treated with HBO. The cerebral edema and neurologic function recovery between two groups were compared. Results: After treatment, the volume of cerebral edema and decreased degree of neurologic impairment score in observation group were obviously more than those in control group(P<0.01). The increased degree of Barthe I index in observation group was significantly higher than that in control group(P<0.01). The difference of the recurrence rate between two group was not statistically significant(P>0.05). Conclusions: The postoperative treatment of meningiomas with HBO can promote the fade away of cerebral edema, and improve the neurologic function.
2016, 41(2): 191-193.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.017
Abstract:
Objective: To investigate the relationship between benign prostatic hyperplasia(BPH) and primary hypertension. Methods: One hundred BPH patients were divided into the BPH complicated with hypertension(group A, 45 cases), and hypertension group(group B, 55 cases). The group A were subdivided into team according to the systolic and diastolic pressure, and the course of hypertension. The age, IPSS, PV, PSA and urinary retention times between two groups were analyzed by statistical method. Results: The age, IPSS, PV and urinary retention times in group A were significantly higher than those in group B(P<0.05 to P<0.01). The difference of age in the patients with systolic pressure more than 160 mmHg was statistically significant(P<0.01). The urinary retention times and PV in group A with systolic pressure from 90 to 110 mmHg and diastolic pressure more than 110 mmHg were higher those in group B(P<0.05 to P<0.01). The age, IPSS and urinary retention times in the patients with hypertension course more than 20 years were more than those in the patients with hypertension course less than 10 years and from 10 years to 20 years(P<0.05 to P<0.01). Conclusions: Hypertension may affect the occurrence and clinical progression of BPH. Early controlling and improving high blood pressure can be conducive to relieving the symptoms.
Objective: To investigate the relationship between benign prostatic hyperplasia(BPH) and primary hypertension. Methods: One hundred BPH patients were divided into the BPH complicated with hypertension(group A, 45 cases), and hypertension group(group B, 55 cases). The group A were subdivided into team according to the systolic and diastolic pressure, and the course of hypertension. The age, IPSS, PV, PSA and urinary retention times between two groups were analyzed by statistical method. Results: The age, IPSS, PV and urinary retention times in group A were significantly higher than those in group B(P<0.05 to P<0.01). The difference of age in the patients with systolic pressure more than 160 mmHg was statistically significant(P<0.01). The urinary retention times and PV in group A with systolic pressure from 90 to 110 mmHg and diastolic pressure more than 110 mmHg were higher those in group B(P<0.05 to P<0.01). The age, IPSS and urinary retention times in the patients with hypertension course more than 20 years were more than those in the patients with hypertension course less than 10 years and from 10 years to 20 years(P<0.05 to P<0.01). Conclusions: Hypertension may affect the occurrence and clinical progression of BPH. Early controlling and improving high blood pressure can be conducive to relieving the symptoms.
2016, 41(2): 194-196.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.018
Abstract:
Objective: To observe the effects and adverse reactions of paclitaxel combined with capecitabine or fluorouracil in the treatment of advanced gastric cancer. Methods: Seven-six patients with advanced gastric cancer were randomly divided into the observation group and control group(38 cases each group). The observation group were treated with paclitaxel combined with capecitabine, the mixture of 150 mg/m2 of paclitaxel(at day 1 and 8) and 0.9% sodium chloride injection was intravenously injected for 3 h, and the 750 mg/m2 of capecitabine was used by oral 2 times daily from day 1 to 14. The control group were treated with paclitaxel combined with fluorouracil, the usage of paclitaxel was the same as the observation group, the 500 mg/m2 of 5-fluorouracil was used once a day for 5 d after 2 h of the 130 mg/m2 of leucovorin calcium intravenous dripping. Results: The effective rates of the observation group and control group were 52.63%, and 50.00%, respectively, the difference of which was not statistically significant(P>0.05). The median progression-free time and median survival time in observation group and control group were 6.7 months & 11.8 months and 6.2 months & 11.3 months, respectively. The difference of 1-year survival rate between two groups was not statistically significant(P>0.05). The incidence of hand-foot syndrome in observation group was significantly higher than that in control group(P<0.01). Conclusions: The effects of paclitaxel combined with capecitabine or fluorouracil in the treatment of advanced gastric cancer are similar, the tolerance of patients is good.
Objective: To observe the effects and adverse reactions of paclitaxel combined with capecitabine or fluorouracil in the treatment of advanced gastric cancer. Methods: Seven-six patients with advanced gastric cancer were randomly divided into the observation group and control group(38 cases each group). The observation group were treated with paclitaxel combined with capecitabine, the mixture of 150 mg/m2 of paclitaxel(at day 1 and 8) and 0.9% sodium chloride injection was intravenously injected for 3 h, and the 750 mg/m2 of capecitabine was used by oral 2 times daily from day 1 to 14. The control group were treated with paclitaxel combined with fluorouracil, the usage of paclitaxel was the same as the observation group, the 500 mg/m2 of 5-fluorouracil was used once a day for 5 d after 2 h of the 130 mg/m2 of leucovorin calcium intravenous dripping. Results: The effective rates of the observation group and control group were 52.63%, and 50.00%, respectively, the difference of which was not statistically significant(P>0.05). The median progression-free time and median survival time in observation group and control group were 6.7 months & 11.8 months and 6.2 months & 11.3 months, respectively. The difference of 1-year survival rate between two groups was not statistically significant(P>0.05). The incidence of hand-foot syndrome in observation group was significantly higher than that in control group(P<0.01). Conclusions: The effects of paclitaxel combined with capecitabine or fluorouracil in the treatment of advanced gastric cancer are similar, the tolerance of patients is good.
2016, 41(2): 197-199.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.019
Abstract:
Objective: To investigate the effects of dexmedetomidine(DEX) on preoperative oxidative stress caused by laparoscopic cholecystectomy. Methods: Eighty patients scheduled for laparoscopic cholecystectomy in our hospital from Mar. 2012 to Jun. 2013 were randomly divided into the DEX group(D group) and control group(C group)(40 cases each group). The D and C groups were intravenously and continuously infused using DEX and isovolume normal saline after anesthesia induction. The serum levels of MDA, SOD and ROS in two groups before operation(T0), at the moment of opening pneumoperitoneum(T1), at the end of operation(T2) and after 24 h of operation(T3) were measured. Results: The differences of the preoperative blood pressure and heart rate change between two groups were not statistical significance(P>0.05). Compared with T0, the serum levels of MDA and ROS, and level of SOD at T1, T2, T3 in two groups were singificantly higher and lower, respectively(P<0.01). The levels of MDA, SOD and ROS at T1, T2 and T3 in D group were significantly lower than those in C group(P<0.01). Conclusions: Continuously intravenous injection of dexmedetomidine can effectively alleviate the preoperative oxidative stress caused by laparoscopic cholecystectomy.
Objective: To investigate the effects of dexmedetomidine(DEX) on preoperative oxidative stress caused by laparoscopic cholecystectomy. Methods: Eighty patients scheduled for laparoscopic cholecystectomy in our hospital from Mar. 2012 to Jun. 2013 were randomly divided into the DEX group(D group) and control group(C group)(40 cases each group). The D and C groups were intravenously and continuously infused using DEX and isovolume normal saline after anesthesia induction. The serum levels of MDA, SOD and ROS in two groups before operation(T0), at the moment of opening pneumoperitoneum(T1), at the end of operation(T2) and after 24 h of operation(T3) were measured. Results: The differences of the preoperative blood pressure and heart rate change between two groups were not statistical significance(P>0.05). Compared with T0, the serum levels of MDA and ROS, and level of SOD at T1, T2, T3 in two groups were singificantly higher and lower, respectively(P<0.01). The levels of MDA, SOD and ROS at T1, T2 and T3 in D group were significantly lower than those in C group(P<0.01). Conclusions: Continuously intravenous injection of dexmedetomidine can effectively alleviate the preoperative oxidative stress caused by laparoscopic cholecystectomy.
2016, 41(2): 200-201,204.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.020
Abstract:
Objective: To explore the clinical effects of Liss and GSH in the treatment of distal femur fracture. Methods: According to the AO typing, patient's physical condition and local soft tissue situation, the type A1, A2, A3, C1 and C2 in 19 patients(GSH group) and type A1, A2, A3, C1, C2 and C3 in 18 patients(Liss group) were treated with GSH and Liss, respectively. The fracture healing time and HSS scores between two groups were compared. Results: All cases were followed up. The fractures were anatomically reset, and the incision was smooth healed. The heal time of fractures in GSH and Liss group were(5.0±1.2) and(4.8±1.17) months, respectively, the difference of which was not statistically significant(P>0.05). The HSS knee scores in GSH and Liss group were(89.4±10.6) and(89.9±11.11), respectively, the difference of which was not statistically significant(P>0.05). Conclusions: The treatment of distal femur fracture with Liss and GSH can achieve good effects, the difference of which is no obvious.
Objective: To explore the clinical effects of Liss and GSH in the treatment of distal femur fracture. Methods: According to the AO typing, patient's physical condition and local soft tissue situation, the type A1, A2, A3, C1 and C2 in 19 patients(GSH group) and type A1, A2, A3, C1, C2 and C3 in 18 patients(Liss group) were treated with GSH and Liss, respectively. The fracture healing time and HSS scores between two groups were compared. Results: All cases were followed up. The fractures were anatomically reset, and the incision was smooth healed. The heal time of fractures in GSH and Liss group were(5.0±1.2) and(4.8±1.17) months, respectively, the difference of which was not statistically significant(P>0.05). The HSS knee scores in GSH and Liss group were(89.4±10.6) and(89.9±11.11), respectively, the difference of which was not statistically significant(P>0.05). Conclusions: The treatment of distal femur fracture with Liss and GSH can achieve good effects, the difference of which is no obvious.
2016, 41(2): 202-204.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.021
Abstract:
Objective: To compare the effects of two different anaesthetic methods on the anesthesia recovery of patients after supratentorial tumor resction. Methods: Sixty-six patients were randomly divided into the propofol-remifentanil(PR group) and sevoflurane-sufentanil(SS group). The PR group and SS group were anaesthetized using propofol-remifentanil and sevoflurane-sufentanil under the bispectral index(BIS) monitor, respectively. The time of the spontanous breathing recovering, extubation and response in two groups were evaluated after operation. The time at Simplified Sedation Score(SSS) less than or equal to 1, Glasgow Coma Scale(GCS) equal to 15, Pain Visual Analogue Scale(PVAS) less than 4, Mini-mENTAL sTATE(MMS) equal to 30 and Aldrete Score(AS) equal to 10 in two groups were recorded. Results: The differences of the spontanous breathing recovering time, extubation time and response time between two group were not statistically significant(P>0.05). The time at the postoperative AS equal to 10, MMS equal to 30 and GCS equal to 15 in SS group was sooner than those in PR group(P<0.05). The differences of the time at PVAS less than 4 and SSS less than or equal to 1 between two groups were not statistically significant(P>0.05). Conclusions: The anesthesia recovery time between the propofol-remifentanil and sevoflurane-sufentanil in patients after supratentorial tumor resction under the bispectral index monitor has no significant difference. The sevoflurane-sufentanil can improve the neural function recovery of patients.
Objective: To compare the effects of two different anaesthetic methods on the anesthesia recovery of patients after supratentorial tumor resction. Methods: Sixty-six patients were randomly divided into the propofol-remifentanil(PR group) and sevoflurane-sufentanil(SS group). The PR group and SS group were anaesthetized using propofol-remifentanil and sevoflurane-sufentanil under the bispectral index(BIS) monitor, respectively. The time of the spontanous breathing recovering, extubation and response in two groups were evaluated after operation. The time at Simplified Sedation Score(SSS) less than or equal to 1, Glasgow Coma Scale(GCS) equal to 15, Pain Visual Analogue Scale(PVAS) less than 4, Mini-mENTAL sTATE(MMS) equal to 30 and Aldrete Score(AS) equal to 10 in two groups were recorded. Results: The differences of the spontanous breathing recovering time, extubation time and response time between two group were not statistically significant(P>0.05). The time at the postoperative AS equal to 10, MMS equal to 30 and GCS equal to 15 in SS group was sooner than those in PR group(P<0.05). The differences of the time at PVAS less than 4 and SSS less than or equal to 1 between two groups were not statistically significant(P>0.05). Conclusions: The anesthesia recovery time between the propofol-remifentanil and sevoflurane-sufentanil in patients after supratentorial tumor resction under the bispectral index monitor has no significant difference. The sevoflurane-sufentanil can improve the neural function recovery of patients.
2016, 41(2): 205-207.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.022
Abstract:
Objective: To investigate the effects of the labor on the early postpartum pelvic floor function and pelvic floor dysfunction. Methods: The postpartum pelvic floor muscle and vaginal pressure in ninty-seven puerpera were detected. The puerpera were divided into the spontaneous vaginal delivery group(62 cases) and cesarean section group(35 cases). The pelvic floor muscle pressure, vaginal pressure, stress urinary incontinence and pelvic organ prolapse in all puerpera were observed. Results: The total normal rates of pelvic floor muscle strength in spontaneous vaginal delivery group and cesarean section group were 58.06% and 65.71%, respectively, the difference of which was not statistically significant(P>0.05). The stress urinary incontinence rates in spontaneous vaginal delivery group and cesarean section group were 19.35% and 2.86%, respectively, the difference of which was statistically significant(P<0.05). The normal rates of vaginal pressure in spontaneous vaginal delivery group and cesarean section group were 72.58% and 71.43%, respectively, the difference of which was not statistically significant(P>0.05). The prolapse rates of the anterior vaginal wall and vaginal wall in spontaneous vaginal delivery group and cesarean section group were 93.55% & 32.26% and 57.14% &5.71%, respectively, the differences of whose were statistically significant(P<0.01). The rates of uterine prolapse in spontaneous vaginal delivery group and cesarean section group were 14.52% and 11.43%, respectively, the difference of which was not statistically significant(P>0.05). Conclusions: Different mode of delivery can make a certain degree of damage on the postpartum pelvic floor muscle. Postpartum pelvic floor rehabilitation exercises as soon as possible can reduce the incidence of pelvic floor dysfunction, and improve quality of life.
Objective: To investigate the effects of the labor on the early postpartum pelvic floor function and pelvic floor dysfunction. Methods: The postpartum pelvic floor muscle and vaginal pressure in ninty-seven puerpera were detected. The puerpera were divided into the spontaneous vaginal delivery group(62 cases) and cesarean section group(35 cases). The pelvic floor muscle pressure, vaginal pressure, stress urinary incontinence and pelvic organ prolapse in all puerpera were observed. Results: The total normal rates of pelvic floor muscle strength in spontaneous vaginal delivery group and cesarean section group were 58.06% and 65.71%, respectively, the difference of which was not statistically significant(P>0.05). The stress urinary incontinence rates in spontaneous vaginal delivery group and cesarean section group were 19.35% and 2.86%, respectively, the difference of which was statistically significant(P<0.05). The normal rates of vaginal pressure in spontaneous vaginal delivery group and cesarean section group were 72.58% and 71.43%, respectively, the difference of which was not statistically significant(P>0.05). The prolapse rates of the anterior vaginal wall and vaginal wall in spontaneous vaginal delivery group and cesarean section group were 93.55% & 32.26% and 57.14% &5.71%, respectively, the differences of whose were statistically significant(P<0.01). The rates of uterine prolapse in spontaneous vaginal delivery group and cesarean section group were 14.52% and 11.43%, respectively, the difference of which was not statistically significant(P>0.05). Conclusions: Different mode of delivery can make a certain degree of damage on the postpartum pelvic floor muscle. Postpartum pelvic floor rehabilitation exercises as soon as possible can reduce the incidence of pelvic floor dysfunction, and improve quality of life.
2016, 41(2): 208-210,214.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.023
Abstract:
Objective: To investigate the correlation between the cognitive dysfunction and event-related potential(ERP) in patients with cerebral infarction. Methods: Forty-three paitents with symptomatic cerebral infarction, 43 patients with asymptomatic cerebral infarction and 43 heathy people were divided into the SCI group, ACI group and control group, respectively. The cognitive function in 3 groups were evaluated using Montreal Assessment Scale Beijing edition(MoCA), and 2 kinds of ERP, N400 and mismatch negativity(MMN) in 3 groups were detected using evoked potential detector, the correlations of MMN, N400 and MoCA score were analyzed, and the MMN and N400 in different parts of cerebral infarction were compared. Results: The MoCA scores in ACI group and SCI group were significantly lower than that in control group, and the MoCA score in SCI group was lower than that in ACI group. Compared with the control group, the extending latency and decreasing amplitude of MMN and N400 in SCI group and ACI group were found(P<0.01). The latency of MMN and N400 and amplitude of N400 in SCI group were higher and lower than those in ACI group, respectively(P<0.01 and P<0.05). The latency of MMN and N400 were negative correlation with MoCA score, the amplitude of MMN and N400 were postive correlation with MoCA score. The latency and amplitude of MMN and N400 in posterior circulation infarction patients were significantly higher and lower than those in the anterior circulation infarction patients, respectively(P<0.01). Conclusions: Patients with symptomatic or asymptomatic cerebral infarction have cognitive dysfunction, which can be early detected using ERP, and MMN has a higher correlation with cognitive dysfunction.
Objective: To investigate the correlation between the cognitive dysfunction and event-related potential(ERP) in patients with cerebral infarction. Methods: Forty-three paitents with symptomatic cerebral infarction, 43 patients with asymptomatic cerebral infarction and 43 heathy people were divided into the SCI group, ACI group and control group, respectively. The cognitive function in 3 groups were evaluated using Montreal Assessment Scale Beijing edition(MoCA), and 2 kinds of ERP, N400 and mismatch negativity(MMN) in 3 groups were detected using evoked potential detector, the correlations of MMN, N400 and MoCA score were analyzed, and the MMN and N400 in different parts of cerebral infarction were compared. Results: The MoCA scores in ACI group and SCI group were significantly lower than that in control group, and the MoCA score in SCI group was lower than that in ACI group. Compared with the control group, the extending latency and decreasing amplitude of MMN and N400 in SCI group and ACI group were found(P<0.01). The latency of MMN and N400 and amplitude of N400 in SCI group were higher and lower than those in ACI group, respectively(P<0.01 and P<0.05). The latency of MMN and N400 were negative correlation with MoCA score, the amplitude of MMN and N400 were postive correlation with MoCA score. The latency and amplitude of MMN and N400 in posterior circulation infarction patients were significantly higher and lower than those in the anterior circulation infarction patients, respectively(P<0.01). Conclusions: Patients with symptomatic or asymptomatic cerebral infarction have cognitive dysfunction, which can be early detected using ERP, and MMN has a higher correlation with cognitive dysfunction.
2016, 41(2): 211-214.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.024
Abstract:
Objective: To observe the effects and safety of the dexmedetomidine combined with tramadol on preventing post-anesthetic hyperalgesia induced by remifentanil. Methods: Eighty patients scheduled by operation were randomly divided into the control group(Group D), tramadol group(Group Q), dexmedetomidine group(Group Y) and dexmedetomidine combined with tramadol group(Group L)(20 cases each group). The HR and MAP in different stages, awakening time, trachea extubation time, VAS pain scores before and after operation, number of patients treated with supplementary analgesic drugs after 24 h of operation and adverse reactions were recorded. Results: The HR and MAP in group D and group Q at trachea extubation, after 5 and 10 min of extubation were significantly higher than those in group Y and group L(P<0.01), the differences of HR and MAP in Y and group L were not statistically significant(P>0.05). The awakening time in group L were longer than those in group D and group Q(P<0.05), the trachea extubation time in group Y were longer than that in group D(P<0.05). The VAS scores in group D at all postoperative time points were significantly higher than that before treatment(P<0.01). The VAS scores in group Q, Y and L at all postoperative time points were significantly less than in group D(P<0.01). The VAS scores in group L at all postoperative time points were significantly less than in group Q and L(P<0.01). The supplementary analgesic drugs in L group at postoperative 24 h was significantly less than that in group D, Q and Y(P<0.01), the differences of the incidence of nausea, vomiting and chills between four groups at postoperative 24 h were not statistically significant(P>0.05), the incidence of restless in group Y and group L were significantly less than that in group D and group Q(P<0.05 to P<0.01). Conclusions: The dexmedetomidine combined with tramadol can prevent post-anesthetic hyperalgesia induced by remifentanil, and provide good sedation and analgesia, stable hemodynamics during extubation, and do not increase the postoperative nausea and vomiting.
Objective: To observe the effects and safety of the dexmedetomidine combined with tramadol on preventing post-anesthetic hyperalgesia induced by remifentanil. Methods: Eighty patients scheduled by operation were randomly divided into the control group(Group D), tramadol group(Group Q), dexmedetomidine group(Group Y) and dexmedetomidine combined with tramadol group(Group L)(20 cases each group). The HR and MAP in different stages, awakening time, trachea extubation time, VAS pain scores before and after operation, number of patients treated with supplementary analgesic drugs after 24 h of operation and adverse reactions were recorded. Results: The HR and MAP in group D and group Q at trachea extubation, after 5 and 10 min of extubation were significantly higher than those in group Y and group L(P<0.01), the differences of HR and MAP in Y and group L were not statistically significant(P>0.05). The awakening time in group L were longer than those in group D and group Q(P<0.05), the trachea extubation time in group Y were longer than that in group D(P<0.05). The VAS scores in group D at all postoperative time points were significantly higher than that before treatment(P<0.01). The VAS scores in group Q, Y and L at all postoperative time points were significantly less than in group D(P<0.01). The VAS scores in group L at all postoperative time points were significantly less than in group Q and L(P<0.01). The supplementary analgesic drugs in L group at postoperative 24 h was significantly less than that in group D, Q and Y(P<0.01), the differences of the incidence of nausea, vomiting and chills between four groups at postoperative 24 h were not statistically significant(P>0.05), the incidence of restless in group Y and group L were significantly less than that in group D and group Q(P<0.05 to P<0.01). Conclusions: The dexmedetomidine combined with tramadol can prevent post-anesthetic hyperalgesia induced by remifentanil, and provide good sedation and analgesia, stable hemodynamics during extubation, and do not increase the postoperative nausea and vomiting.
2016, 41(2): 215-216,219.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.025
Abstract:
Objective: To explore the expression of ribosome binding protein 1(RRBP1) in thyroid cancer and its relationship with clinicopathological characteristics. Methods: The expressions of RRBP1 in 86 thyroid cancer specimens and 15 adjacent normal tissue specimens were detected using immunohistochemical method, and the relationship between the expression of RRBP1 and clinicopathological characteristics of thyroid cancer was analyzed. Results: The positive rates of RRBP1 expression in thyroid cancer and normal tissue were 77.9% and 20.0%, respectively, and the difference of which was statistically significant(P<0.01). The positive rates of RRBP1 in thyroid cancer patients with tumor size ≥ 2 cm, stage Ⅲ-Ⅳ and lymph node metastasis were significantly higher than that in the patients with tumor size < 2 cm, satgeⅠ-Ⅱ and non-lymph node metastasis(P<0.05). The differences of the positive rate of RRBP1 expression in different ages, sex, smoking history and tumor location were not statistically significant(P>0.05). Conclusions: RRBP1 can be used as a novel molecular marker in the occurrence of thyroid cancer, and its expression is closely related to the clinicopathological characteristics.
Objective: To explore the expression of ribosome binding protein 1(RRBP1) in thyroid cancer and its relationship with clinicopathological characteristics. Methods: The expressions of RRBP1 in 86 thyroid cancer specimens and 15 adjacent normal tissue specimens were detected using immunohistochemical method, and the relationship between the expression of RRBP1 and clinicopathological characteristics of thyroid cancer was analyzed. Results: The positive rates of RRBP1 expression in thyroid cancer and normal tissue were 77.9% and 20.0%, respectively, and the difference of which was statistically significant(P<0.01). The positive rates of RRBP1 in thyroid cancer patients with tumor size ≥ 2 cm, stage Ⅲ-Ⅳ and lymph node metastasis were significantly higher than that in the patients with tumor size < 2 cm, satgeⅠ-Ⅱ and non-lymph node metastasis(P<0.05). The differences of the positive rate of RRBP1 expression in different ages, sex, smoking history and tumor location were not statistically significant(P>0.05). Conclusions: RRBP1 can be used as a novel molecular marker in the occurrence of thyroid cancer, and its expression is closely related to the clinicopathological characteristics.
2016, 41(2): 217-219.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.026
Abstract:
Objective: To explore the anti-platelet effects and safety of double dose of clopidogrel in acute ST-segment elevation myocardial infarction patients after percutaneous coronary intervention(PCI). Methods: Eighty acute ST-segment elevation myocardial infarction patients with PCI were randomly divided into the treatment group and control group(40 cases each group). The control group were treated with 100 mg aspirin and 75 mg clopidogrel once a day by oral. The treatment group were treated with 100 mg aspirin once a day and 75 mg clopidogrel twice a day for 1 month, then changed to 75 mg clopidogrel once a day by oral. After a month of treatment, the platelet aggregation rates in two groups were observed. The incidence of cardiovascular events in two groups were analyzed after 1 year of following up. Results: The difference of the platelet aggregation rate between two groups after 1 month of treatment was statistically significant(P<0.05). The differences of remyocardial infarction, cardiac mortality and incidence of stent thrombosis between two groups after 1 year of following up were not statistically significant(P>0.05). Conclusions: The treatment of acute ST-segment elevation myocardial infarction patients PCI with double dose of clopidogrel can decrease the cardiovascular events.
Objective: To explore the anti-platelet effects and safety of double dose of clopidogrel in acute ST-segment elevation myocardial infarction patients after percutaneous coronary intervention(PCI). Methods: Eighty acute ST-segment elevation myocardial infarction patients with PCI were randomly divided into the treatment group and control group(40 cases each group). The control group were treated with 100 mg aspirin and 75 mg clopidogrel once a day by oral. The treatment group were treated with 100 mg aspirin once a day and 75 mg clopidogrel twice a day for 1 month, then changed to 75 mg clopidogrel once a day by oral. After a month of treatment, the platelet aggregation rates in two groups were observed. The incidence of cardiovascular events in two groups were analyzed after 1 year of following up. Results: The difference of the platelet aggregation rate between two groups after 1 month of treatment was statistically significant(P<0.05). The differences of remyocardial infarction, cardiac mortality and incidence of stent thrombosis between two groups after 1 year of following up were not statistically significant(P>0.05). Conclusions: The treatment of acute ST-segment elevation myocardial infarction patients PCI with double dose of clopidogrel can decrease the cardiovascular events.
2016, 41(2): 227-229,234.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.030
Abstract:
Objective: To explore the nutritional knowledge-attitude-practice(KAP) status and dietary structure among college students for improvement of their nutritional health. Methods: Self-designed questionnaires were distributed to 1 373 college students which were selected by cluster sampling from Bengbu Medical College randomly to investigate their nutritional KAP status. Results: There were significant differences between students with different nutritional KAP scores in age, sex, grade, monthly food consumption and body mass index(BMI)(P<0.05 to P<0.01). There were significant differences between students with different nutritional knowledge scores in age, sex, grade and area(P<0.01). Logistic regression analysis showed that the scores of nutritional KAP were related to sex and grade(P<0.01), excluding the confounding factors, the results showed that nutritional KAP scores of girls and high grade's students were 1.882 and 2.402 times of boys and low grade's students. Conclusions: Students in our school have low knowledge of nutritional information, especially the source and role of some common nutrients. But most of them have the active attitude, so the effective nutritional education should be performed to improve their nutritional level, then to improve the physical and mental development in college students.
Objective: To explore the nutritional knowledge-attitude-practice(KAP) status and dietary structure among college students for improvement of their nutritional health. Methods: Self-designed questionnaires were distributed to 1 373 college students which were selected by cluster sampling from Bengbu Medical College randomly to investigate their nutritional KAP status. Results: There were significant differences between students with different nutritional KAP scores in age, sex, grade, monthly food consumption and body mass index(BMI)(P<0.05 to P<0.01). There were significant differences between students with different nutritional knowledge scores in age, sex, grade and area(P<0.01). Logistic regression analysis showed that the scores of nutritional KAP were related to sex and grade(P<0.01), excluding the confounding factors, the results showed that nutritional KAP scores of girls and high grade's students were 1.882 and 2.402 times of boys and low grade's students. Conclusions: Students in our school have low knowledge of nutritional information, especially the source and role of some common nutrients. But most of them have the active attitude, so the effective nutritional education should be performed to improve their nutritional level, then to improve the physical and mental development in college students.
2016, 41(2): 230-234.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.031
Abstract:
Objective: To investigate the career maturity of vocational school students and its affecting factors. Methods: Nine hundred and ninety-five students from vocational school of Huaibei were investigated using cross-sectional study method, which included the general questionnaire, career maturity inventory and self-supporting personality scale. The data were analyzed using F-test and q test, t(or t') test, correlation and multiple stepwise regression. Results: The average score of career maturity dimensions was larger than 3 points, and participating practical activities could significantly improve the score of career maturity. The differences of career maturity in gender, grade, birth place, speciality, family economics were statistically significant(P<0.05 to P<0.01). The career maturity of vocational school students was significantly positive correlation with the most dimensions of self-supporting personality(P<0.01). The multivariate analysis showed that the interpersonal reliance, individual self-reliance, practical activities, father's occupation were correlated with career maturity(P<0.01). Conclusions: Career maturity of vocational school students is higher. Career maturity of vocational school students is related to the gender, grade, hometown, speciality, practical activities, economic status of family and self-supporting personality. The practical activities, father's occupation and self-supporting personality have a predictive role on the career maturity.
Objective: To investigate the career maturity of vocational school students and its affecting factors. Methods: Nine hundred and ninety-five students from vocational school of Huaibei were investigated using cross-sectional study method, which included the general questionnaire, career maturity inventory and self-supporting personality scale. The data were analyzed using F-test and q test, t(or t') test, correlation and multiple stepwise regression. Results: The average score of career maturity dimensions was larger than 3 points, and participating practical activities could significantly improve the score of career maturity. The differences of career maturity in gender, grade, birth place, speciality, family economics were statistically significant(P<0.05 to P<0.01). The career maturity of vocational school students was significantly positive correlation with the most dimensions of self-supporting personality(P<0.01). The multivariate analysis showed that the interpersonal reliance, individual self-reliance, practical activities, father's occupation were correlated with career maturity(P<0.01). Conclusions: Career maturity of vocational school students is higher. Career maturity of vocational school students is related to the gender, grade, hometown, speciality, practical activities, economic status of family and self-supporting personality. The practical activities, father's occupation and self-supporting personality have a predictive role on the career maturity.
2016, 41(2): 235-236.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.032
Abstract:
Objective: To investigate the situation of demodex infection in students in Chuzhou, and analyze its reasons for providing the experimental evidence in preventing and treating the demodex infection. Methods: One hundred and sixty-two medical students and 186 non-medical students were investigated using the transparent adhesive tape overnight method and self-made questionnaire. The demodex was observed using optical microscopy. Results: The infection rate of demodex in medical students was significantly lower than that in non-medical students(P<0.01), and the awareness rate of demodex in medical students was significantly higher than that in non-medical students(P<0.01). Conclusions: Popularizing the demodex knowledge and improving the demodex awareness have great significance in preventing the demodex infection and demodicidosis.
Objective: To investigate the situation of demodex infection in students in Chuzhou, and analyze its reasons for providing the experimental evidence in preventing and treating the demodex infection. Methods: One hundred and sixty-two medical students and 186 non-medical students were investigated using the transparent adhesive tape overnight method and self-made questionnaire. The demodex was observed using optical microscopy. Results: The infection rate of demodex in medical students was significantly lower than that in non-medical students(P<0.01), and the awareness rate of demodex in medical students was significantly higher than that in non-medical students(P<0.01). Conclusions: Popularizing the demodex knowledge and improving the demodex awareness have great significance in preventing the demodex infection and demodicidosis.
2016, 41(2): 237-239.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.033
Abstract:
Objective: To investigate the marriage and procreation condition of epilepsy patients of Zhuang nationality in Guangxi and to analyze the influencing factors. Methods: Sixty epilepsy patients of Zhuang nationality in Guangxi province were selected as the epilepsy group and 60 healthy subjects were randomly selected as the control group at the same period. The questionnaire survey method was adopted to investigate the marriage status, family situation, personal income and epilepsy disease of all the subjects;and regression analysis was used to analyze the related factors affecting their marital status. Results: The average marrying age of both the male and female in the epilepsy group was higher than that in the control group(P<0.05 and P<0.01);the marriage and fertility rates of the male in the epilepsy group were obviously lower than those in the control group (P<0.05), but the marriage and fertility rates of the female had no statistical differences between the two groups(P>0.05). The health situation of the children showed that the control group had 1 case of congenital atrial septal defect and the epilepsy group 1 case of congenital cleft lip, which had no statistical significant difference(P>0.05). The number of married epilepsy patients who had a junior high school or above education background(P<0.01) and a monthly income of over 2 000 yuan was higher than that of the unmarried (P<0.01);the medical expense had no difference between the two groups(P>0.05). The average onset age of the married people was higher than that of the unmarried (P<0.01), and the course of the disease was obviously shorter than that of the unmarried (P<0.01);the epilepsy seizures, syndrome types and duration of the epilepsy seizures of the married and unmarried people had no significant differences (P>0.05), but the frequency of epileptic seizures had significant differences (P<0.01). Logistic regression analysis showed that gender, age of onset, income, educational level, course of the disease and frequency of epileptic seizures were all factors affecting the epilepsy patients' marriage situation(P<0.01). Conclusions: The marriage rate and fertility rate of the male epilepsy patients of Zhuang nationality in Guangxi province are markedly lower than those of the healthy control;and gender, age of onset, income, education degree, course and frequency of epileptic seizures are all closely related to the marital status of the epilepsy patients.
Objective: To investigate the marriage and procreation condition of epilepsy patients of Zhuang nationality in Guangxi and to analyze the influencing factors. Methods: Sixty epilepsy patients of Zhuang nationality in Guangxi province were selected as the epilepsy group and 60 healthy subjects were randomly selected as the control group at the same period. The questionnaire survey method was adopted to investigate the marriage status, family situation, personal income and epilepsy disease of all the subjects;and regression analysis was used to analyze the related factors affecting their marital status. Results: The average marrying age of both the male and female in the epilepsy group was higher than that in the control group(P<0.05 and P<0.01);the marriage and fertility rates of the male in the epilepsy group were obviously lower than those in the control group (P<0.05), but the marriage and fertility rates of the female had no statistical differences between the two groups(P>0.05). The health situation of the children showed that the control group had 1 case of congenital atrial septal defect and the epilepsy group 1 case of congenital cleft lip, which had no statistical significant difference(P>0.05). The number of married epilepsy patients who had a junior high school or above education background(P<0.01) and a monthly income of over 2 000 yuan was higher than that of the unmarried (P<0.01);the medical expense had no difference between the two groups(P>0.05). The average onset age of the married people was higher than that of the unmarried (P<0.01), and the course of the disease was obviously shorter than that of the unmarried (P<0.01);the epilepsy seizures, syndrome types and duration of the epilepsy seizures of the married and unmarried people had no significant differences (P>0.05), but the frequency of epileptic seizures had significant differences (P<0.01). Logistic regression analysis showed that gender, age of onset, income, educational level, course of the disease and frequency of epileptic seizures were all factors affecting the epilepsy patients' marriage situation(P<0.01). Conclusions: The marriage rate and fertility rate of the male epilepsy patients of Zhuang nationality in Guangxi province are markedly lower than those of the healthy control;and gender, age of onset, income, education degree, course and frequency of epileptic seizures are all closely related to the marital status of the epilepsy patients.
2016, 41(2): 240-244.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.034
Abstract:
Objective: To explore the effects of different clinical factors on the stress level of nursing trainees. Methods: The nursing trainees from hospitals in Hefei city from April to June 2015 were selected by stratified random sampling method. The gender, age, origin, character, whether the one-child, professional degree, school grades and other general information in all nursing trainees were investigated using self-made general information questionnaire. The stress levels of all trainees were investigated using the stressor table. Results: The scores of patient's situation, supervision and evaluation in introverted undergraduate nursing students were higher than those in extroverts nursing students(P<0.01). The differences of the nature of work and content, demand of knowledge and skill, and total scores in undergraduate nursing trainees with different professional affection were statistically significant(P<0.01 to P<0.05), and the nature of work and content, demand of knowledge and skill and total scores in undergraduate nursing trainees without professional affection were higher than those in undergraduate nursing trainees with professional affection(P<0.01 to P<0.05). The differences of the scores of the demand of knowledge and skills, and teaching arrangement were statistically significant(P<0.01 and P<0.05), and the scores of the demand for knowledge and skills, and teaching arrangement in undergraduate nursing trainees with general and poor grades were higher than those in undergraduate nursing trainees with excellent grade(P<0.05 to P<0.01). The differences of the scores of stress level and each stressor in different gender, age, origin and whether the one-child were not statistically significant(P>0.05). Conclusions: The effects of different clinical factors on different stressors in undergraduate nursing trainees are different. The nursing educators should give the active support and help according to the characteristics of nursing students.
Objective: To explore the effects of different clinical factors on the stress level of nursing trainees. Methods: The nursing trainees from hospitals in Hefei city from April to June 2015 were selected by stratified random sampling method. The gender, age, origin, character, whether the one-child, professional degree, school grades and other general information in all nursing trainees were investigated using self-made general information questionnaire. The stress levels of all trainees were investigated using the stressor table. Results: The scores of patient's situation, supervision and evaluation in introverted undergraduate nursing students were higher than those in extroverts nursing students(P<0.01). The differences of the nature of work and content, demand of knowledge and skill, and total scores in undergraduate nursing trainees with different professional affection were statistically significant(P<0.01 to P<0.05), and the nature of work and content, demand of knowledge and skill and total scores in undergraduate nursing trainees without professional affection were higher than those in undergraduate nursing trainees with professional affection(P<0.01 to P<0.05). The differences of the scores of the demand of knowledge and skills, and teaching arrangement were statistically significant(P<0.01 and P<0.05), and the scores of the demand for knowledge and skills, and teaching arrangement in undergraduate nursing trainees with general and poor grades were higher than those in undergraduate nursing trainees with excellent grade(P<0.05 to P<0.01). The differences of the scores of stress level and each stressor in different gender, age, origin and whether the one-child were not statistically significant(P>0.05). Conclusions: The effects of different clinical factors on different stressors in undergraduate nursing trainees are different. The nursing educators should give the active support and help according to the characteristics of nursing students.
2016, 41(2): 245-246.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.035
Abstract:
Objective: To evaluate the effects of evidence-based medicine(EBM) on clinical practice teaching in pediatrics. Methods: One hundred and twenty undergraduates from class 2010 clinical medicine in a medical college were randomly divided into the control group and observation group(60 students each group). The control group and observation group were taught with the traditional clinical practice teaching model and EBM guiding clinical practice teaching model, respectively. The learning effects and teaching evaluation of students between two groups were compared. Results: The scores of the theory and skills assessment, and teaching evaluation of students in observation group were significantly higher than those in control group(P<0.01). Conclusions: The application of EBM model in clinical practice teaching in pediatrics can significantly improve the learning effects of students, and help to cultivate the clinical practice ability of student.
Objective: To evaluate the effects of evidence-based medicine(EBM) on clinical practice teaching in pediatrics. Methods: One hundred and twenty undergraduates from class 2010 clinical medicine in a medical college were randomly divided into the control group and observation group(60 students each group). The control group and observation group were taught with the traditional clinical practice teaching model and EBM guiding clinical practice teaching model, respectively. The learning effects and teaching evaluation of students between two groups were compared. Results: The scores of the theory and skills assessment, and teaching evaluation of students in observation group were significantly higher than those in control group(P<0.01). Conclusions: The application of EBM model in clinical practice teaching in pediatrics can significantly improve the learning effects of students, and help to cultivate the clinical practice ability of student.
2016, 41(2): 249-251.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.037
Abstract:
Objective: To evaluate the effectiveness of standardized cases(SC) in measurement of the nursing students' humanistc caring ability. Methods: A total of 100 practice nursing students were randomly divided into two groups(n=50 in each group). Group A adopted SC evaluation and group B assessment questionnaire by domestic scholars to determine their humanistic caring ability;then the satisfaction degree of the patients was investigated. The coincidence of their scores and the patients' satisfaction degree was compared and the effects of SC evaluation analyzed. Results: Group B achieved higher scores in questionnaires about health education, scientific solution of health problems and assistant meeting of the patients basic needs than group A in SC evaluation(P<0.05). Among the students with the score number of the first 15 and middle 20, the total score of humanistic caring ability of group B was higher than that of group A(P<0.01), while there was no statistical difference among students with the score number of last 15(P>0.05). The patient's satisfaction demonstrated no significant difference among students with different scores in humanistic care ability(P>0.05). The three nursing students with low satisfaction degree(average≤1) in group A were all among the last 15 in scores;However, the students with score number of the first 15 obtained higher satisfaction degree. Among the students with the score number of the first 15 in group B, only one got low satisfaction degree(average≤1). Conclusions: SC evaluation is accurate and effective in assessing the humanistic caring ability of the nursing students. It can be used as one of the standards in evaluating the students' humanistic caring ability before graduation and going to a post.
Objective: To evaluate the effectiveness of standardized cases(SC) in measurement of the nursing students' humanistc caring ability. Methods: A total of 100 practice nursing students were randomly divided into two groups(n=50 in each group). Group A adopted SC evaluation and group B assessment questionnaire by domestic scholars to determine their humanistic caring ability;then the satisfaction degree of the patients was investigated. The coincidence of their scores and the patients' satisfaction degree was compared and the effects of SC evaluation analyzed. Results: Group B achieved higher scores in questionnaires about health education, scientific solution of health problems and assistant meeting of the patients basic needs than group A in SC evaluation(P<0.05). Among the students with the score number of the first 15 and middle 20, the total score of humanistic caring ability of group B was higher than that of group A(P<0.01), while there was no statistical difference among students with the score number of last 15(P>0.05). The patient's satisfaction demonstrated no significant difference among students with different scores in humanistic care ability(P>0.05). The three nursing students with low satisfaction degree(average≤1) in group A were all among the last 15 in scores;However, the students with score number of the first 15 obtained higher satisfaction degree. Among the students with the score number of the first 15 in group B, only one got low satisfaction degree(average≤1). Conclusions: SC evaluation is accurate and effective in assessing the humanistic caring ability of the nursing students. It can be used as one of the standards in evaluating the students' humanistic caring ability before graduation and going to a post.
2016, 41(2): 252-253,256.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.038
Abstract:
Objective: To investigate the effects of stress management training on alleviating the stress during pregnancy. Methods: One hundred early pregnant women with mild stress were chosen, and divided into the observation group and the control group(50 cases each group) using convenience sampling method. The control group were treated with routine prenatal check and pregnancy knowledge consultation, and the stress management training of the observation group were implemented through the conventional check, knowledge lectures combined with individual consultation, continuous 7 times, each time 20 min. The effects in two groups were evaluated using the pregnancy stress scale after intervention. Results: After the intervention, the increasing stress level in observation group in late pregnancy was significantly lower than that in control group(P<0.01). Conclusions: Stress management training can alleviate the stress of pregnant women during pregnancy, make it through pregnancy and childbirth period, effectively promote the health of mother and infant.
Objective: To investigate the effects of stress management training on alleviating the stress during pregnancy. Methods: One hundred early pregnant women with mild stress were chosen, and divided into the observation group and the control group(50 cases each group) using convenience sampling method. The control group were treated with routine prenatal check and pregnancy knowledge consultation, and the stress management training of the observation group were implemented through the conventional check, knowledge lectures combined with individual consultation, continuous 7 times, each time 20 min. The effects in two groups were evaluated using the pregnancy stress scale after intervention. Results: After the intervention, the increasing stress level in observation group in late pregnancy was significantly lower than that in control group(P<0.01). Conclusions: Stress management training can alleviate the stress of pregnant women during pregnancy, make it through pregnancy and childbirth period, effectively promote the health of mother and infant.
2016, 41(2): 254-256.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.039
Abstract:
Objective: To explore the clinical features of the urinary tract infection caused by indwelling urethral catheter in children of urinary surgery and its nursing countermeasures. Methods: The clinical data of the incidence, related factors, pathogenic bacteria distribution and drug resistance surveillance of urinary tract infection in 532 children with indwelling urethral catheter in department of urology were retrospectively analyzed. Results: The incidence of urinary tract infection in children with indwelling catheter was 13.3%. The urinary tract infection rate in female children was higher than that in male children(P<0.01). The urinary tract infection rate in 7 to 15 years old children was higher than that in 1 to 6 years old children(P<0.01). The urinary tract infection rate in children with indwelling urethral catheter for 8 to 14 days was higher than that in children with indwelling urethral catheter for 1 to 7 days(P<0.01). The main pathogenic bacteria of urinary tract infection were enterococcus faecalis, escherichia coli and enterococcus faecium in turn, which accounted for 28.0%, 22.7% and 21.3%, respectively. Both the sensitivities of 21 strains of enterococcus faecalis to ampicillin and penicillin were 100.0%, but the sensitivities of enterococcus faecalis to gentamicin, rifampicin and minocycline were high. Both the resistant rates of enterococcus faecium to penicillin and ampicillin were 87.5%, but the sensitivities of enterococcus faecium to vancomycin, nitrofurantoin, teicoplanin and linezolid were high. Both the resistant rate of escherichia coli to ampicillin and piperacillin were 94.1%, and it was sensitive to imipenem. Conclusions: Urinary tract infection is associated with gender, age, and indwelling time. It is necessary to take effective nursing measures to reduce the incidence of urinary tract infection caused by catheter.
Objective: To explore the clinical features of the urinary tract infection caused by indwelling urethral catheter in children of urinary surgery and its nursing countermeasures. Methods: The clinical data of the incidence, related factors, pathogenic bacteria distribution and drug resistance surveillance of urinary tract infection in 532 children with indwelling urethral catheter in department of urology were retrospectively analyzed. Results: The incidence of urinary tract infection in children with indwelling catheter was 13.3%. The urinary tract infection rate in female children was higher than that in male children(P<0.01). The urinary tract infection rate in 7 to 15 years old children was higher than that in 1 to 6 years old children(P<0.01). The urinary tract infection rate in children with indwelling urethral catheter for 8 to 14 days was higher than that in children with indwelling urethral catheter for 1 to 7 days(P<0.01). The main pathogenic bacteria of urinary tract infection were enterococcus faecalis, escherichia coli and enterococcus faecium in turn, which accounted for 28.0%, 22.7% and 21.3%, respectively. Both the sensitivities of 21 strains of enterococcus faecalis to ampicillin and penicillin were 100.0%, but the sensitivities of enterococcus faecalis to gentamicin, rifampicin and minocycline were high. Both the resistant rates of enterococcus faecium to penicillin and ampicillin were 87.5%, but the sensitivities of enterococcus faecium to vancomycin, nitrofurantoin, teicoplanin and linezolid were high. Both the resistant rate of escherichia coli to ampicillin and piperacillin were 94.1%, and it was sensitive to imipenem. Conclusions: Urinary tract infection is associated with gender, age, and indwelling time. It is necessary to take effective nursing measures to reduce the incidence of urinary tract infection caused by catheter.
2016, 41(2): 257-258,262.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.040
Abstract:
Objective: To observe the effect of extensional nursing service on post-stroke deficient patients who were doing functional exercises at the recovering stage. Methods: Seventy patients were randomly divided into observation group and control group(n=35 in each) according to the diagnosis standard. The control group were given one time telephone follow-up after discharge from hospital, while the observation group were given telephone follow-up once a week and health education twice a month for a total of 8 weeks(2 months). At 1 week and 8 weeks after discharge, the patients in both groups were evaluated by using the Fugl-Meyer physical exercises function evaluation sheet and Barthel daily life ability data evaluation sheet. Results: The observation group obtained higher scores than the control group in Fugl-Meyer physical exercises function evaluation sheet and Barthel daily life ability data evaluation sheet (P<0.01). Conclusions: The extensional nursing service may enhance the compliance of post-stroke deficient patients doing functional exercises at the recovery phase and help to make their injured limb recover to the maximum extent.
Objective: To observe the effect of extensional nursing service on post-stroke deficient patients who were doing functional exercises at the recovering stage. Methods: Seventy patients were randomly divided into observation group and control group(n=35 in each) according to the diagnosis standard. The control group were given one time telephone follow-up after discharge from hospital, while the observation group were given telephone follow-up once a week and health education twice a month for a total of 8 weeks(2 months). At 1 week and 8 weeks after discharge, the patients in both groups were evaluated by using the Fugl-Meyer physical exercises function evaluation sheet and Barthel daily life ability data evaluation sheet. Results: The observation group obtained higher scores than the control group in Fugl-Meyer physical exercises function evaluation sheet and Barthel daily life ability data evaluation sheet (P<0.01). Conclusions: The extensional nursing service may enhance the compliance of post-stroke deficient patients doing functional exercises at the recovery phase and help to make their injured limb recover to the maximum extent.
2016, 41(2): 259-262.
doi: 10.13898/j.cnki.issn.1000-2200.2016.02.041
Abstract:
Objective: To study the prevalence of anxiety and depression in patients with chronic kidney disease(CKD) and the effects of social support on these negative emotions. Methods: A total of 118 inpatients with CKD were surveyed with self-evaluation of anxiety scale(SAS), self-rating of depression scale(SDS) and social support rating scale. Logistic regression analysis was adopted to investigate the influence of social support on the anxiety and depression in patients with CKD. Results: The prevalence of anxiety and depression among CKD patients was 24.58% and 41.53% respectively;and the average score of SAS and SDS was 35.11±7.39 and 39.19±8.32 respectively, which was significantly higher than the national norm(SAS:29.78±10.07, SDS:33.46±8.55)(P<0.01). The average score of social support was 40.9±7.9, which was negatively correlated with SAS(r=-0.28, P<0.01) and SDS(r=-0.22, P<0.05) score. Logistic regression analysis showed that social support was the protective factor for anxiety(OR=0.534, 95%CI:0.30~0.95, P<0.05), while female(OR=2.316, 95%CI:1.01~5.30, P<0.05) and CKD stages(OR=1.536, 95%CI:1.07~2.22, P<0.05) were the risk factors for depression. Conclusions: The positive rates of anxiety and depression in patients with CKD are higher than those in the general population. Social support is the the only protective factor for the negative emotions in patients with CKD.
Objective: To study the prevalence of anxiety and depression in patients with chronic kidney disease(CKD) and the effects of social support on these negative emotions. Methods: A total of 118 inpatients with CKD were surveyed with self-evaluation of anxiety scale(SAS), self-rating of depression scale(SDS) and social support rating scale. Logistic regression analysis was adopted to investigate the influence of social support on the anxiety and depression in patients with CKD. Results: The prevalence of anxiety and depression among CKD patients was 24.58% and 41.53% respectively;and the average score of SAS and SDS was 35.11±7.39 and 39.19±8.32 respectively, which was significantly higher than the national norm(SAS:29.78±10.07, SDS:33.46±8.55)(P<0.01). The average score of social support was 40.9±7.9, which was negatively correlated with SAS(r=-0.28, P<0.01) and SDS(r=-0.22, P<0.05) score. Logistic regression analysis showed that social support was the protective factor for anxiety(OR=0.534, 95%CI:0.30~0.95, P<0.05), while female(OR=2.316, 95%CI:1.01~5.30, P<0.05) and CKD stages(OR=1.536, 95%CI:1.07~2.22, P<0.05) were the risk factors for depression. Conclusions: The positive rates of anxiety and depression in patients with CKD are higher than those in the general population. Social support is the the only protective factor for the negative emotions in patients with CKD.
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