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2016 Vol. 41, No. 4
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2016, 41(4): 421-425.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.001
Abstract:
Objective: To study the relationship between the properties and the structures of the benzimidazole complexes, and explore the preparation method of new antibacterial benzimidazole complexes materials. Methods: Under solvothermal conditions, the assembly of 4, 4'-bis (benzimidazol-1-ylmethy1) biphenyl, isophthalic acid and cobalt, nickel salts resulting two new complexes{[Co (bbmb)(IPA)]·(H2O)3}n (1) and{[Ni (bbmb)(IPA)(H2O)]·H2O}n (2). The complexes were characterized by single crystal X-ray structure analyses, thermogravimetric analyses, powder X-ray diffraction and solid-state ultraviolet measurements. Results: Complex 1 had a 2-dimentional sheet framework with S-shaped chains while complex 2 had a 2-dimentional sheet framework constructed from zigzag chains and straight chains. The solid-state UV-Vis absorbance properties were investigated. Conclusions: The structures and properties of the two new benzimidazole complexes are well studied, to provide approaches for the design and exploitation of new benzimidazole complex materials with potential antibacterial activities.
Objective: To study the relationship between the properties and the structures of the benzimidazole complexes, and explore the preparation method of new antibacterial benzimidazole complexes materials. Methods: Under solvothermal conditions, the assembly of 4, 4'-bis (benzimidazol-1-ylmethy1) biphenyl, isophthalic acid and cobalt, nickel salts resulting two new complexes{[Co (bbmb)(IPA)]·(H2O)3}n (1) and{[Ni (bbmb)(IPA)(H2O)]·H2O}n (2). The complexes were characterized by single crystal X-ray structure analyses, thermogravimetric analyses, powder X-ray diffraction and solid-state ultraviolet measurements. Results: Complex 1 had a 2-dimentional sheet framework with S-shaped chains while complex 2 had a 2-dimentional sheet framework constructed from zigzag chains and straight chains. The solid-state UV-Vis absorbance properties were investigated. Conclusions: The structures and properties of the two new benzimidazole complexes are well studied, to provide approaches for the design and exploitation of new benzimidazole complex materials with potential antibacterial activities.
2016, 41(4): 426-430.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.002
Abstract:
Objective: To investigate the value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS) in S. typhimurium homology analysis. Methods: Forty-four S. typhimuium strains isolated from Guangzhou were typed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, which was compared with pulse-field gel electrophoresis(PFGE) to analyze the main patterns of mass spectrogram. Results: The PFGE results showed that 44 S. typhimuium strains could be divided into 15 types. At 80% of the clustering similarity, 44 S. typhimuium strains could be divided into 8 MALDI-TOF MS types, which was accordance to the PFGE results. The MS1(52.3%) was the main type, which contained multiple PFGE patterns. Conclusions: The classification results of MALDI-TOF MS show the relative concentration of kinship of S. typhimuium isolated from Guangzhou, which is a simple, rapid, high throughput method of classification.
Objective: To investigate the value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS) in S. typhimurium homology analysis. Methods: Forty-four S. typhimuium strains isolated from Guangzhou were typed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, which was compared with pulse-field gel electrophoresis(PFGE) to analyze the main patterns of mass spectrogram. Results: The PFGE results showed that 44 S. typhimuium strains could be divided into 15 types. At 80% of the clustering similarity, 44 S. typhimuium strains could be divided into 8 MALDI-TOF MS types, which was accordance to the PFGE results. The MS1(52.3%) was the main type, which contained multiple PFGE patterns. Conclusions: The classification results of MALDI-TOF MS show the relative concentration of kinship of S. typhimuium isolated from Guangzhou, which is a simple, rapid, high throughput method of classification.
2016, 41(4): 431-433.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.003
Abstract:
Objective: To explore the effects of lipopolysaccharide(LPS) on the expression of Toll-like receptor 4(TLR4) and production of intracellular reactive oxygen species(ROS) in peripheral blood mononuclear cells of tuberculosis(TB) patients. Methods: The peripheral blood samples from 13 TB patients and 13 health volunteers were collected, which was dyed with ROS probe DHR123 or anti-TLR4-PE. The expression of TLR4 and production of intracellular ROS in peripheral blood mononuclear cells of TB patients and health volunteers were detected using flow cytometry. The 100 μL anticoagulant blood were cultured in 96-well plates, and divided into group A, group B, group C(6 wells each group) and cultured for 24 h, and treated with 100 ng/mL LPS. The expression of TLR4 and production of intracellular ROS in peripheral blood mononuclear cells were detected by flow cytometry. Results: The positive expression rate of TLR4 in peripheral blood mononuclear cells in TB patients[(17.6±3.6)%] was significantly lower than that in health volunteer[(30.0±2.4)%](P<0.01). The level of ROS in peripheral blood mononuclear cells in TB patients(74.8±11.4) was significantly lower than that in health volunteer(109.6±13.2)(P<0.01). After LPS stimulating for 24 h, the difference of the level of intracellular ROS between group C(182.1±11.3) and group B(127.6±14.1) was statistically significant(P<0.01), and the difference of the expression level of intrcellular TLR4 between group C[(62.1±3.3)%] and group B[(47.6±4.7)%] was statistically significant(P<0.01). Conclusions: LPS can increase the TLR4 expression and intracellular ROS production of peripheral blood mononuclear cells in TB patients.
Objective: To explore the effects of lipopolysaccharide(LPS) on the expression of Toll-like receptor 4(TLR4) and production of intracellular reactive oxygen species(ROS) in peripheral blood mononuclear cells of tuberculosis(TB) patients. Methods: The peripheral blood samples from 13 TB patients and 13 health volunteers were collected, which was dyed with ROS probe DHR123 or anti-TLR4-PE. The expression of TLR4 and production of intracellular ROS in peripheral blood mononuclear cells of TB patients and health volunteers were detected using flow cytometry. The 100 μL anticoagulant blood were cultured in 96-well plates, and divided into group A, group B, group C(6 wells each group) and cultured for 24 h, and treated with 100 ng/mL LPS. The expression of TLR4 and production of intracellular ROS in peripheral blood mononuclear cells were detected by flow cytometry. Results: The positive expression rate of TLR4 in peripheral blood mononuclear cells in TB patients[(17.6±3.6)%] was significantly lower than that in health volunteer[(30.0±2.4)%](P<0.01). The level of ROS in peripheral blood mononuclear cells in TB patients(74.8±11.4) was significantly lower than that in health volunteer(109.6±13.2)(P<0.01). After LPS stimulating for 24 h, the difference of the level of intracellular ROS between group C(182.1±11.3) and group B(127.6±14.1) was statistically significant(P<0.01), and the difference of the expression level of intrcellular TLR4 between group C[(62.1±3.3)%] and group B[(47.6±4.7)%] was statistically significant(P<0.01). Conclusions: LPS can increase the TLR4 expression and intracellular ROS production of peripheral blood mononuclear cells in TB patients.
2016, 41(4): 434-437.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.004
Abstract:
Objective: To measure the bony structure of petrous bone and explore relationship between the nerve and blood vessel around the tentorium cerebelli hiatus to provide the anatomical basis in subtemporal transtentorial approach. Methods: The highest point of the arcuate eminence was set as the base-point, the distance of the outer edge of foramen lacerum, hiatus canalis facialis and posterior border of the internal auditory foramen from the base-point in 15 cases(30 sides) were measured. The superior cerebellar artery, posterior cerebral artery, oculomotor nerve, trochlear nerve, trigeminal nerve and tentorium of cerebellum, and their relationship with tentorium cerebelli were observed in 10(20 sides) heads with subtemporal transtentorial approach. Results: The distances of the highest point of arcuate eminence from the outer edge of Foramen lacerum, hiatus canalis facialis and posterior border of the internal auditory foramen were(34.98±1.67)mm, (14.67±1.74)mm and(15.31±1.78)mm, respectively. The distance between the terminations of the labbe vein and STP(including transverse sinus, sigmoid sinus and rock junction of the sinus) was (24.60±5.82)mm, and the distance between the trochlear nerve into the free margin of the tentorium and posterior clinoid were(15.50±3.85) mm, respectively. Conclusions: Measuring the distances of the highest point of arcuate eminence from outer edge of foramen lacerum, hiatus canalis facialis and posterior border of the internal auditory foramen and detecting the tracks of superior cerebellar artery, posterior cerebral artery, oculomotor nerve, trochlear nerve and trigeminal nerve around the tentorium of cerebellum can improve the safety and successful rate in subtemporal transtentorial approach.
Objective: To measure the bony structure of petrous bone and explore relationship between the nerve and blood vessel around the tentorium cerebelli hiatus to provide the anatomical basis in subtemporal transtentorial approach. Methods: The highest point of the arcuate eminence was set as the base-point, the distance of the outer edge of foramen lacerum, hiatus canalis facialis and posterior border of the internal auditory foramen from the base-point in 15 cases(30 sides) were measured. The superior cerebellar artery, posterior cerebral artery, oculomotor nerve, trochlear nerve, trigeminal nerve and tentorium of cerebellum, and their relationship with tentorium cerebelli were observed in 10(20 sides) heads with subtemporal transtentorial approach. Results: The distances of the highest point of arcuate eminence from the outer edge of Foramen lacerum, hiatus canalis facialis and posterior border of the internal auditory foramen were(34.98±1.67)mm, (14.67±1.74)mm and(15.31±1.78)mm, respectively. The distance between the terminations of the labbe vein and STP(including transverse sinus, sigmoid sinus and rock junction of the sinus) was (24.60±5.82)mm, and the distance between the trochlear nerve into the free margin of the tentorium and posterior clinoid were(15.50±3.85) mm, respectively. Conclusions: Measuring the distances of the highest point of arcuate eminence from outer edge of foramen lacerum, hiatus canalis facialis and posterior border of the internal auditory foramen and detecting the tracks of superior cerebellar artery, posterior cerebral artery, oculomotor nerve, trochlear nerve and trigeminal nerve around the tentorium of cerebellum can improve the safety and successful rate in subtemporal transtentorial approach.
2016, 41(4): 438-444.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.005
Abstract:
Objective: To analyze the T-lymphocyte subsets change in peripheral blood of patients with chronic hepatitis B(CHB), and its correlation with hepatitis B-deoxyribonucleic acid(HBV-DNA). Methods: The relative literatures of T-lymphocyte subsets change in peripheral blood of patients with CHB from Medline(PubMed retrieval platform), Embase(Ovild retrieve platform), Central(Ovild retrieval platform), Whip, Wanfang and CNKI from January 1, 2000 to December 31, 2013 were searched. Independent screening documents, extracting information and evaluation were implemented independently by 2 evaluators according to the inclusion and exclusion criteria, which was analyzed by Meta using RevMan 5.3 software. Results: The percentage of CD3+T, CD4+T and CD4+T/CD8+T in patients with CHB were lower than those in healthy people, but the percentage of CD8+T cells of patients was higher(P<0.05). Compared with the HBeAg(-) patients, the percentage of CD4+T and CD8+T decreased and increased significantly in HBeAg(+) patients, respectively(P<0.01), the difference of CD4+T/CD8+ between HBeAg(-) and HBeAg(+) patients was not statistical significance(P>0.05). Compared with the negative HBV DNA patients, the percentage of CD3+T, CD4+T and CD4+T/CD8+T, and percentage of CD8+T decreased and increased significantly in the positive HBV DNA patients, respectively(P<0.01). Compared with the low copies of HBV DNA patients, the percentage of CD4+T and CD4+T/CD8+T and percentage of CD8+T decreased and increased significantly in high copies of HBV DNA patients, respectively(P<0.01), the difference of percentage of CD3+T between the low and high copies of HBV DNA patients was not statistical significance(P>0.05). Conclusions: HBV infection can lead to the change of T cell subsets of patients, which is positively related to the HBV-DNA level.
Objective: To analyze the T-lymphocyte subsets change in peripheral blood of patients with chronic hepatitis B(CHB), and its correlation with hepatitis B-deoxyribonucleic acid(HBV-DNA). Methods: The relative literatures of T-lymphocyte subsets change in peripheral blood of patients with CHB from Medline(PubMed retrieval platform), Embase(Ovild retrieve platform), Central(Ovild retrieval platform), Whip, Wanfang and CNKI from January 1, 2000 to December 31, 2013 were searched. Independent screening documents, extracting information and evaluation were implemented independently by 2 evaluators according to the inclusion and exclusion criteria, which was analyzed by Meta using RevMan 5.3 software. Results: The percentage of CD3+T, CD4+T and CD4+T/CD8+T in patients with CHB were lower than those in healthy people, but the percentage of CD8+T cells of patients was higher(P<0.05). Compared with the HBeAg(-) patients, the percentage of CD4+T and CD8+T decreased and increased significantly in HBeAg(+) patients, respectively(P<0.01), the difference of CD4+T/CD8+ between HBeAg(-) and HBeAg(+) patients was not statistical significance(P>0.05). Compared with the negative HBV DNA patients, the percentage of CD3+T, CD4+T and CD4+T/CD8+T, and percentage of CD8+T decreased and increased significantly in the positive HBV DNA patients, respectively(P<0.01). Compared with the low copies of HBV DNA patients, the percentage of CD4+T and CD4+T/CD8+T and percentage of CD8+T decreased and increased significantly in high copies of HBV DNA patients, respectively(P<0.01), the difference of percentage of CD3+T between the low and high copies of HBV DNA patients was not statistical significance(P>0.05). Conclusions: HBV infection can lead to the change of T cell subsets of patients, which is positively related to the HBV-DNA level.
2016, 41(4): 445-447.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.006
Abstract:
Objective: To explore the relationship between lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) and glucose level in initial diagnosis type 2 diabetes patients(T2DM). Methods: Sixty-eight initial diagnosis T2DM patients were divided into the observation group, and fifty-six non-diabetic healthy people with the same age, sex, waist circumference and BMI as the observation group were set as the control group. The levels of fasting blood glucose(FBG), glycosylated hemoglobin A1c(HbA1c), serum lipid and LOX-1 in two groups were tested. The relationship between LOX-1 and HbA1c was analyzed. Results: The levels of FBG, HbA1c, LOX-1 and LDL-cholesterol in observation group were significantly higher than those in control group(P<0.01). The level of HbA1c was positive correlation with LOX-1(P<0.01), and the level of lipids was not correlation with the LOX-1(P>0.05). Multivariate linear stepwise regression analysis showed that the HbA1c level increasing was the independent risk factor of the LOX-1 level increasing(P<0.01). Conclusions: High blood glucose may directly lead to the expression of LOX-1 increasing, which can initiate the atherosclerosis of diabetes.
Objective: To explore the relationship between lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) and glucose level in initial diagnosis type 2 diabetes patients(T2DM). Methods: Sixty-eight initial diagnosis T2DM patients were divided into the observation group, and fifty-six non-diabetic healthy people with the same age, sex, waist circumference and BMI as the observation group were set as the control group. The levels of fasting blood glucose(FBG), glycosylated hemoglobin A1c(HbA1c), serum lipid and LOX-1 in two groups were tested. The relationship between LOX-1 and HbA1c was analyzed. Results: The levels of FBG, HbA1c, LOX-1 and LDL-cholesterol in observation group were significantly higher than those in control group(P<0.01). The level of HbA1c was positive correlation with LOX-1(P<0.01), and the level of lipids was not correlation with the LOX-1(P>0.05). Multivariate linear stepwise regression analysis showed that the HbA1c level increasing was the independent risk factor of the LOX-1 level increasing(P<0.01). Conclusions: High blood glucose may directly lead to the expression of LOX-1 increasing, which can initiate the atherosclerosis of diabetes.
2016, 41(4): 448-450.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.007
Abstract:
Objective: To investigate the clinical effects of SUT ultrasonic scanning therapeutic apparatus combined with atorvastatin in the treatment of the carotid plaque and low density lipoprotein(LDL). Methods: A total of 240 patients with carotid plaque diagnosed by carotid artery color ultrasound were randomly divided into the control group and combination group according to the random number table method(120 cases each group). The control group and combination group were treated with atorvastatin and SUT ultrasound scanner combined with atorvastatin, respectively. The carotid plaque property and area, and LDL level between two groups were analyzed before treatment, and after 3 and 6 months of treatment. Results: After 6 months of treatment in the combination group, the carotid plaque property tended to stabilize, the carotid plaque area reduced significantly and the LDL decreased significantly(P<0.01). The differences of the carotid plaque area and LDL between two groups were statistically significant after 6 months of treatment(P<0.01). Conclusions: The treatment of carotid plaque with SUT ultrasonic scanning therapeutic apparatus combined with atorvastatin can make carotid plaque stable and shrink, and effectively reduce the level of LDL.
Objective: To investigate the clinical effects of SUT ultrasonic scanning therapeutic apparatus combined with atorvastatin in the treatment of the carotid plaque and low density lipoprotein(LDL). Methods: A total of 240 patients with carotid plaque diagnosed by carotid artery color ultrasound were randomly divided into the control group and combination group according to the random number table method(120 cases each group). The control group and combination group were treated with atorvastatin and SUT ultrasound scanner combined with atorvastatin, respectively. The carotid plaque property and area, and LDL level between two groups were analyzed before treatment, and after 3 and 6 months of treatment. Results: After 6 months of treatment in the combination group, the carotid plaque property tended to stabilize, the carotid plaque area reduced significantly and the LDL decreased significantly(P<0.01). The differences of the carotid plaque area and LDL between two groups were statistically significant after 6 months of treatment(P<0.01). Conclusions: The treatment of carotid plaque with SUT ultrasonic scanning therapeutic apparatus combined with atorvastatin can make carotid plaque stable and shrink, and effectively reduce the level of LDL.
2016, 41(4): 451-454.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.008
Abstract:
Objective: To review the etiology in 4 582 adult patients with fever of unknown origin(FUO) in Chinese literature from 1990 to 2013, and compare the differences between north and south areas and changes in different periods. Methods: Four thousand five hundred and eighty-two patients with FUO in 21 clinical research literatures from 1 360 literatures searched from China National Knowledge Infrastructure(CNKI) database containing the key word "fever of unknown origin" from 1990 to 2013. The data were analyzed according to the difference between north and south areas, and changes in early period(1990 to 2003) and later period(2004 to 2013). Results: Among the 4 582 FUO cases, the definite diagnosis was 90.9%. The most common cause of FUO was the infectious disease(54.4%), and the tuberculosis was more common(16.2%). The patients with rheumatic autoimmune disease accounted for 15.5%, adult Still's disease (5.6%) was more common. The tumor(more common in 4.5% lymphoma), miscellaneous causes(more common in 3.1% of drug-induced fever) and unknown reason accounted for 13.2%, 7.8% and 9.1%, respectively. The proportions of infectious disease and tumor in the South were significantly higher than those in the North(P<0.01 and P<0.05). The proportions of rheumatic autoimmune disease, drug-induced fever and miscellaneous causes in the South were lower than those in the North(P<0.01). The pathogeny proportions of the infectious disease, drug-induced fever and miscellaneous cause in early period of FUO were significantly lower than those in later period(P<0.01), while the pathogeny proportions of the viral disease, tumor and miscellaneous cause in early period of FUO were significantly higher than those in later period (P<0.01). Conclusions: The infectious disease is the most common cause of FUO. There are some differences in pathogeny constituent between north and south areas, which changes over time.
Objective: To review the etiology in 4 582 adult patients with fever of unknown origin(FUO) in Chinese literature from 1990 to 2013, and compare the differences between north and south areas and changes in different periods. Methods: Four thousand five hundred and eighty-two patients with FUO in 21 clinical research literatures from 1 360 literatures searched from China National Knowledge Infrastructure(CNKI) database containing the key word "fever of unknown origin" from 1990 to 2013. The data were analyzed according to the difference between north and south areas, and changes in early period(1990 to 2003) and later period(2004 to 2013). Results: Among the 4 582 FUO cases, the definite diagnosis was 90.9%. The most common cause of FUO was the infectious disease(54.4%), and the tuberculosis was more common(16.2%). The patients with rheumatic autoimmune disease accounted for 15.5%, adult Still's disease (5.6%) was more common. The tumor(more common in 4.5% lymphoma), miscellaneous causes(more common in 3.1% of drug-induced fever) and unknown reason accounted for 13.2%, 7.8% and 9.1%, respectively. The proportions of infectious disease and tumor in the South were significantly higher than those in the North(P<0.01 and P<0.05). The proportions of rheumatic autoimmune disease, drug-induced fever and miscellaneous causes in the South were lower than those in the North(P<0.01). The pathogeny proportions of the infectious disease, drug-induced fever and miscellaneous cause in early period of FUO were significantly lower than those in later period(P<0.01), while the pathogeny proportions of the viral disease, tumor and miscellaneous cause in early period of FUO were significantly higher than those in later period (P<0.01). Conclusions: The infectious disease is the most common cause of FUO. There are some differences in pathogeny constituent between north and south areas, which changes over time.
2016, 41(4): 455-457.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.009
Abstract:
Objective: To explore the significance of early measurement of plasma paraquat concentration in assessing the severity of kidney injury and predicting the outcome in patients with acute paraquat poisoning. Methods: According to the plasma paraquat concentration measured on admission, 55 patients with APP were divided into low concentration group (<0.5 μg/mL) in 15 cases, middle concentration group(0.5 to 2.0 μg/mL) in 15 cases, and 25 cases with high concentration(>2.0 μg/mL). The highest values of serum urea and creatinine levels were detected during hospitalization in these groups were compared, the mortality was also compared. Results: Serum creatinine and urea levels were significantly higher in high and middle concentration groups than those in low concentration group (P<0.01), while serum urea level in middle concentration group was significantly higher than that in high concentration group (P<0.01). The mortality was higher in high concentration group than in middle and low concentration groups(P<0.05 and P<0.01). Conclusions: Plasma paraquat concentration measured in the early stage of paraquat poisoning could be used to assess the severity of kidney injury and predict the outcome in patients with acute paraquat poisoning.
Objective: To explore the significance of early measurement of plasma paraquat concentration in assessing the severity of kidney injury and predicting the outcome in patients with acute paraquat poisoning. Methods: According to the plasma paraquat concentration measured on admission, 55 patients with APP were divided into low concentration group (<0.5 μg/mL) in 15 cases, middle concentration group(0.5 to 2.0 μg/mL) in 15 cases, and 25 cases with high concentration(>2.0 μg/mL). The highest values of serum urea and creatinine levels were detected during hospitalization in these groups were compared, the mortality was also compared. Results: Serum creatinine and urea levels were significantly higher in high and middle concentration groups than those in low concentration group (P<0.01), while serum urea level in middle concentration group was significantly higher than that in high concentration group (P<0.01). The mortality was higher in high concentration group than in middle and low concentration groups(P<0.05 and P<0.01). Conclusions: Plasma paraquat concentration measured in the early stage of paraquat poisoning could be used to assess the severity of kidney injury and predict the outcome in patients with acute paraquat poisoning.
2016, 41(4): 458-461.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.010
Abstract:
Objective: To investigate the clinicopathological characteristics of the oncocytic papillary renal cell carcinoma(OPRCC). Methods: Three cases of OPRCC were investigated by light microscopy, immunohistochemistry, fluorescence in situ hybridization(FISH), and review of the literature. Results: Among 3 cases, 2 cases were male, 1 case was female, and their ages were 41, 45 and 65 years old, respectively. The renal masses in 3 cases were found by medical examination. The masses in 2 cases located in the low pole of the kidney, and 1 case mass located in the middle and high pole of the kidney, the surrounding boundaries between the renal tissue and tumor was clear, and the long diameter of 3 masses were 3.0 cm, 3.5 cm and 4.5 cm, respectively. The cytoplasm of tumor cells were plentiful and eosinophilic, the Fuhrman grades of nuclear were from 2 to 3 grade. Tumor cells arranged in papillary pattern with accumulation of foam cells in the stroma. In 3 cases of tumor cells, vimentin, CD10, AMACR, EMA and CK7 were positive, while TFE3, CD15, CD117, RCC and E-cadherin were negative. FISH test showed that the 7 and 17 chromosomes were amplified in 3 cases of tumor cells. Conclusions: OPRCC is a rarely subtype of renal cell carcinoma, and its immune phenotype and molecular genetics are similar to that of type 1 papillary renal cell carcinoma. The OPRCC should be differentiated with oncocytoma, chromophobe renal cell carcinoma, Xp11.2 translocation of renal cell carcinoma.
Objective: To investigate the clinicopathological characteristics of the oncocytic papillary renal cell carcinoma(OPRCC). Methods: Three cases of OPRCC were investigated by light microscopy, immunohistochemistry, fluorescence in situ hybridization(FISH), and review of the literature. Results: Among 3 cases, 2 cases were male, 1 case was female, and their ages were 41, 45 and 65 years old, respectively. The renal masses in 3 cases were found by medical examination. The masses in 2 cases located in the low pole of the kidney, and 1 case mass located in the middle and high pole of the kidney, the surrounding boundaries between the renal tissue and tumor was clear, and the long diameter of 3 masses were 3.0 cm, 3.5 cm and 4.5 cm, respectively. The cytoplasm of tumor cells were plentiful and eosinophilic, the Fuhrman grades of nuclear were from 2 to 3 grade. Tumor cells arranged in papillary pattern with accumulation of foam cells in the stroma. In 3 cases of tumor cells, vimentin, CD10, AMACR, EMA and CK7 were positive, while TFE3, CD15, CD117, RCC and E-cadherin were negative. FISH test showed that the 7 and 17 chromosomes were amplified in 3 cases of tumor cells. Conclusions: OPRCC is a rarely subtype of renal cell carcinoma, and its immune phenotype and molecular genetics are similar to that of type 1 papillary renal cell carcinoma. The OPRCC should be differentiated with oncocytoma, chromophobe renal cell carcinoma, Xp11.2 translocation of renal cell carcinoma.
2016, 41(4): 462-463,466.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.011
Abstract:
Objective: To detect the susceptibility weighted imaging(SWI) of prominent vessel(PV), investigate the correlation of clinical prognosis with cerebral blood volume(CBV) in early acute cerebral infarction patients, and analyze the clinical significance of PV. Methods: The imaging of the head in 22 patients with acute cerebral infarction were examined within 3 days of disease. The imaging of PV in SWI were graded according to the classification of anastomosis vessels of cortex and leptomeningeal. Two lays with obvious PV in lesions were set as the region of interesting(ROI) area. The focal mirror of 3 points in the lesion center and around in ROI area were measured, the CBV value of which was recorded for calculating the average value of parameter in the healthy and disease side. The scores of national institutes of health stroke scale(NIHSS) at admission and after 14 days of disease, and modified Rankin Scale(mRS) after 90 days of disease were analyzed. Results: The PV grading of patient was positive correlation with the CBV of disease side(P<0.05). The PV grading of patient was not correlation with the NIHSS scores at onset and after 14 days of disease, and mRS score after 90 days of disease(P>0.05). Conclusions: The phenomenon and grading of PV in SWI can reflect the cerebral blood volume changes of lesion side in acute cerebral infarction patients.
Objective: To detect the susceptibility weighted imaging(SWI) of prominent vessel(PV), investigate the correlation of clinical prognosis with cerebral blood volume(CBV) in early acute cerebral infarction patients, and analyze the clinical significance of PV. Methods: The imaging of the head in 22 patients with acute cerebral infarction were examined within 3 days of disease. The imaging of PV in SWI were graded according to the classification of anastomosis vessels of cortex and leptomeningeal. Two lays with obvious PV in lesions were set as the region of interesting(ROI) area. The focal mirror of 3 points in the lesion center and around in ROI area were measured, the CBV value of which was recorded for calculating the average value of parameter in the healthy and disease side. The scores of national institutes of health stroke scale(NIHSS) at admission and after 14 days of disease, and modified Rankin Scale(mRS) after 90 days of disease were analyzed. Results: The PV grading of patient was positive correlation with the CBV of disease side(P<0.05). The PV grading of patient was not correlation with the NIHSS scores at onset and after 14 days of disease, and mRS score after 90 days of disease(P>0.05). Conclusions: The phenomenon and grading of PV in SWI can reflect the cerebral blood volume changes of lesion side in acute cerebral infarction patients.
2016, 41(4): 464-466.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.012
Abstract:
Objective: To observe the clinical effects of high flux hemodialysis in the treatment of uremic patients with chronic renal failure. Methods: One hundred and twenty uremic patients with chronic renal failure were randomly divided into the observation group and control group. The observation group and control group were treated with high flux dialysis and conventional hemodialysis, respectively. Results: The total effective rate in observation group(90.0%) was higher than that in control group after treatment(70.0%)(P<0.01). The levels of BUN, Scr, β2-MG and PTH in two groups after dialysis were significantly lower than those in before dialysis(P<0.01). BUN、β2-MG and PTH in observation group decreased significantly higher than the control group(P<0.01) after dialysis, while the Scr is oppsite(P<0.01). After dialysis, the number of cases with body mass index increasing in observation group was significantly higher than that in control group(P<0.01). and the incidence rates of bone and joint pain, fatigue and skin pruritus in observation group were lower than those in control group(P<0.05 to P<0.01). Conclusions: The treatment of uremia patients with chronic renal failure with high flux dialysis can improve the therapeutic effect, strongly clear the large, middle and small molecules, reduce the incidence rate of adverse reactions and improve the life quality of patients, which is worthy of promoting in clinic use.
Objective: To observe the clinical effects of high flux hemodialysis in the treatment of uremic patients with chronic renal failure. Methods: One hundred and twenty uremic patients with chronic renal failure were randomly divided into the observation group and control group. The observation group and control group were treated with high flux dialysis and conventional hemodialysis, respectively. Results: The total effective rate in observation group(90.0%) was higher than that in control group after treatment(70.0%)(P<0.01). The levels of BUN, Scr, β2-MG and PTH in two groups after dialysis were significantly lower than those in before dialysis(P<0.01). BUN、β2-MG and PTH in observation group decreased significantly higher than the control group(P<0.01) after dialysis, while the Scr is oppsite(P<0.01). After dialysis, the number of cases with body mass index increasing in observation group was significantly higher than that in control group(P<0.01). and the incidence rates of bone and joint pain, fatigue and skin pruritus in observation group were lower than those in control group(P<0.05 to P<0.01). Conclusions: The treatment of uremia patients with chronic renal failure with high flux dialysis can improve the therapeutic effect, strongly clear the large, middle and small molecules, reduce the incidence rate of adverse reactions and improve the life quality of patients, which is worthy of promoting in clinic use.
2016, 41(4): 467-469.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.013
Abstract:
Objective: To evaluate the safety and feasibility of cardiac pacemaker combined with ultrasonic scalpel in laparoscopic cholecystectomy(LC) in patients with gallbladder calculi complicated with arrhythmia. Methods: The clinical data of 59 LC patients treated with cardiac pacemaker combined with LC were retrospectively analyzed. Results: All operations of 59 cases were successful. The drop of heart rhythm and blood pressure in one patient was found during placing pacemaker, and the patient recovered after treatment. The postoperative celialgia, icterus, palpitation and chest distress were not found in all patients, all patients cured. Conclusions: The placing cardiac pacemaker before LC in patient with gallbladder calculi complicated with arrhythmia can effectively protect the cardiac function, and reduce, time and complications of the LC.
Objective: To evaluate the safety and feasibility of cardiac pacemaker combined with ultrasonic scalpel in laparoscopic cholecystectomy(LC) in patients with gallbladder calculi complicated with arrhythmia. Methods: The clinical data of 59 LC patients treated with cardiac pacemaker combined with LC were retrospectively analyzed. Results: All operations of 59 cases were successful. The drop of heart rhythm and blood pressure in one patient was found during placing pacemaker, and the patient recovered after treatment. The postoperative celialgia, icterus, palpitation and chest distress were not found in all patients, all patients cured. Conclusions: The placing cardiac pacemaker before LC in patient with gallbladder calculi complicated with arrhythmia can effectively protect the cardiac function, and reduce, time and complications of the LC.
2016, 41(4): 470-472.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.014
Abstract:
Objective: To invetigate the effective method in promoting cervical maturity for providing an effective, safe and convenient delivery approach in overdue gestation. Methods: Ninety pregnant women with induction properties and cervical score less than or equal to 6 points were randomly divided into oxytocin induced labor group(control group A), dinoprostone suppository induced labor group(control group B) and cervical dilation balloon group(study group) by a case-control study(30 cases each group). The effects of cervical maturity, success rate of vaginal delivery, adverse reactions and duration time from using medicine to delivery between three groups were compared. Results: The effective promoting cervical maturity in 29 cases and water balloon off in 1 case of study group were found, 12 cases in control group A and 27 cases in control group B were valid, and the effective rates in study group and control group B were higher than that in control group A(P<0.05). The vaginal delivery of 23 cases in study group, 11 cases in control group A and 22 cases in control group B were successful, the difference of which was statistically significant(P<0.01)). The uterine hyperstimulation in 2 cases of control group B occured, who improved immediately after removing the drug. The neonatal asphyxia in 1 case(Apgar for 7 points) and severe asphyxia in 1 case(Apgar for 3 points) and abnormal fetal heart rate in 6 cases were identified. The abnormal fetal heart rate in 1 case, and no uterine hyperstimulation, tetanic contraction and neonatal asphyxia in study group were identified. The neonatal asphyxia in 2 cases(Apgar for 7 points and 6 points) and abnormal fetal heart rate in 5 cases were found in control group A, the differences of whose between 3 groups were not statistically significant(P>0.05). The duration time from using medicine to delivery in control group A was longer than that in control group B and study group(P<0.05). Conclusions: The effect of cervical dilatation balloon in promoting cervical maturity is similar to dinoprostone suppository, and higher than that of oxytocin, which is mild, safe and less complications.
Objective: To invetigate the effective method in promoting cervical maturity for providing an effective, safe and convenient delivery approach in overdue gestation. Methods: Ninety pregnant women with induction properties and cervical score less than or equal to 6 points were randomly divided into oxytocin induced labor group(control group A), dinoprostone suppository induced labor group(control group B) and cervical dilation balloon group(study group) by a case-control study(30 cases each group). The effects of cervical maturity, success rate of vaginal delivery, adverse reactions and duration time from using medicine to delivery between three groups were compared. Results: The effective promoting cervical maturity in 29 cases and water balloon off in 1 case of study group were found, 12 cases in control group A and 27 cases in control group B were valid, and the effective rates in study group and control group B were higher than that in control group A(P<0.05). The vaginal delivery of 23 cases in study group, 11 cases in control group A and 22 cases in control group B were successful, the difference of which was statistically significant(P<0.01)). The uterine hyperstimulation in 2 cases of control group B occured, who improved immediately after removing the drug. The neonatal asphyxia in 1 case(Apgar for 7 points) and severe asphyxia in 1 case(Apgar for 3 points) and abnormal fetal heart rate in 6 cases were identified. The abnormal fetal heart rate in 1 case, and no uterine hyperstimulation, tetanic contraction and neonatal asphyxia in study group were identified. The neonatal asphyxia in 2 cases(Apgar for 7 points and 6 points) and abnormal fetal heart rate in 5 cases were found in control group A, the differences of whose between 3 groups were not statistically significant(P>0.05). The duration time from using medicine to delivery in control group A was longer than that in control group B and study group(P<0.05). Conclusions: The effect of cervical dilatation balloon in promoting cervical maturity is similar to dinoprostone suppository, and higher than that of oxytocin, which is mild, safe and less complications.
2016, 41(4): 473-474,478.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.015
Abstract:
Objective: To investigate the risk factors of macrosomia and its effects on the mode of delivery. Methods: The clinical data of 2 583 puerperas(singleton pregnancy) were retrospectively analyzed. Results: The differences of ages and number of pregnancies and deliveries in all cases were not statistically significant(P>0.05). The differences of the pre-pregnancy and prenatal weight and body mass index, levels of fasting plasma glucose and OGTT 1 h and 2 h, and mode of delivery between macrosomia and normal puerperas were statistically significant(P<0.01). Conclusions: The rate of cesarean section in macrosomia puerpera increases. To control levels of fasting plasma glucose, decrease the prenatal body mass index and terminate pregnancy can reduce the incidence of macrosomia.
Objective: To investigate the risk factors of macrosomia and its effects on the mode of delivery. Methods: The clinical data of 2 583 puerperas(singleton pregnancy) were retrospectively analyzed. Results: The differences of ages and number of pregnancies and deliveries in all cases were not statistically significant(P>0.05). The differences of the pre-pregnancy and prenatal weight and body mass index, levels of fasting plasma glucose and OGTT 1 h and 2 h, and mode of delivery between macrosomia and normal puerperas were statistically significant(P<0.01). Conclusions: The rate of cesarean section in macrosomia puerpera increases. To control levels of fasting plasma glucose, decrease the prenatal body mass index and terminate pregnancy can reduce the incidence of macrosomia.
2016, 41(4): 475-478.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.016
Abstract:
Objective: To evaluate the effects of goal-direct therapy(GDT) on perioperative cardiac enzyme in ectopic pregnancy patients with hemorrhagic shock. Methods: Fifty ectopic pregnancy patients with hemorrhagic shock scheduled by operation were divided into the goal-direct therapy(GDT) group(group A, 25 cases) and conventional infusion treatment group(group B, 25 cases) by random number table method. The hemodynamics change, serum creatine kinase, isoenzyme of creatine kinase and troponin T in two groups were recorded before operation(T0), at the start of operation(T1), after 30 min(T2), 1h(T3), 2h(T4) and at the end of operation(T5), and the data were analyzed. Results: The levels of serum creatine kinase, isoenzyme of creatine kinase and troponin T in group A were lower than those in group B from T2 to T5(P<0.05 to P<0.01). The levels of HR and MAP from T1 to T3 and CVP at T2 in group A were higher than those in group B(P<0.01). Conclusions: The treatment of ectopic pregnancy patients with hemorrhagic shock with GDT can increase the effective capacity load of myocardium, and has a certain myocardial protection.
Objective: To evaluate the effects of goal-direct therapy(GDT) on perioperative cardiac enzyme in ectopic pregnancy patients with hemorrhagic shock. Methods: Fifty ectopic pregnancy patients with hemorrhagic shock scheduled by operation were divided into the goal-direct therapy(GDT) group(group A, 25 cases) and conventional infusion treatment group(group B, 25 cases) by random number table method. The hemodynamics change, serum creatine kinase, isoenzyme of creatine kinase and troponin T in two groups were recorded before operation(T0), at the start of operation(T1), after 30 min(T2), 1h(T3), 2h(T4) and at the end of operation(T5), and the data were analyzed. Results: The levels of serum creatine kinase, isoenzyme of creatine kinase and troponin T in group A were lower than those in group B from T2 to T5(P<0.05 to P<0.01). The levels of HR and MAP from T1 to T3 and CVP at T2 in group A were higher than those in group B(P<0.01). Conclusions: The treatment of ectopic pregnancy patients with hemorrhagic shock with GDT can increase the effective capacity load of myocardium, and has a certain myocardial protection.
2016, 41(4): 479-481.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.017
Abstract:
Objective: To evaluate the significance of hepatitis B virus large protein(HBV-LP) in antiviral treatment of chronic hepatitis B(CHB). Methods: One hundred and twenty CHB patients were treated with entecavir for 96 weeks. The serum levels of HBV-LP and HBV DNA were detected at 0, 12, 24, 36, 48, 72 and 96 weeks of treatment. Results: The differences of the positive rate of HBV-LP and HBV DNA in CHB patients were not statistically significant(P>0.05). During antivirus therapy, the declining of HBV-LP was similar to HBV DNA(P<0.01). The content of HBV-LP was positive correlation with HBV DNA copies(P<0.01). Conclusions: The detection of HBV-LP can provide an effective index in evaluating antiviral treatment.
Objective: To evaluate the significance of hepatitis B virus large protein(HBV-LP) in antiviral treatment of chronic hepatitis B(CHB). Methods: One hundred and twenty CHB patients were treated with entecavir for 96 weeks. The serum levels of HBV-LP and HBV DNA were detected at 0, 12, 24, 36, 48, 72 and 96 weeks of treatment. Results: The differences of the positive rate of HBV-LP and HBV DNA in CHB patients were not statistically significant(P>0.05). During antivirus therapy, the declining of HBV-LP was similar to HBV DNA(P<0.01). The content of HBV-LP was positive correlation with HBV DNA copies(P<0.01). Conclusions: The detection of HBV-LP can provide an effective index in evaluating antiviral treatment.
2016, 41(4): 481-484.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.018
Abstract:
Objective: To compare the clinical effects between pemetrexed combined with dentritic cells(DC), cytokine induced killer cells(CIK), and pemetrexed in the treatment of moderate advanced non-small cell lung cancer(NSCLC). Methods: Forty-six patients with stage Ⅲ or Ⅳ NSCLC were treated with platinum-based two-drug chemotherapy for four cycles, the disease were effectively controlled, and the patients were randomly divided into the control group and combination group. The control group and combination group were treated with pemetrexed and pemetrexed combined with DC-CIK, respectively. The clinical efficacy and adverse reactions between two groups were compared. Results: The disease control rates in control group and combination group were 78.3%and 87.0%, respectively, the difference of which was not statistically significant(P>0.05). The progression-free survival in combination group(6.9 months) was better than that in control group(4.7 months)(P<0.01). The bone marrow suppression and gastrointestinal reaction in two groups were the main adverse reactions, the difference of which was not statistically significant(P>0.05). Fever in 3 cases were found in combination group during DC/CIK infusion. Conclusions: The maintenance treatment of NSCLC with pemetrexed combined with DC-CIK is a safe and effective method.
Objective: To compare the clinical effects between pemetrexed combined with dentritic cells(DC), cytokine induced killer cells(CIK), and pemetrexed in the treatment of moderate advanced non-small cell lung cancer(NSCLC). Methods: Forty-six patients with stage Ⅲ or Ⅳ NSCLC were treated with platinum-based two-drug chemotherapy for four cycles, the disease were effectively controlled, and the patients were randomly divided into the control group and combination group. The control group and combination group were treated with pemetrexed and pemetrexed combined with DC-CIK, respectively. The clinical efficacy and adverse reactions between two groups were compared. Results: The disease control rates in control group and combination group were 78.3%and 87.0%, respectively, the difference of which was not statistically significant(P>0.05). The progression-free survival in combination group(6.9 months) was better than that in control group(4.7 months)(P<0.01). The bone marrow suppression and gastrointestinal reaction in two groups were the main adverse reactions, the difference of which was not statistically significant(P>0.05). Fever in 3 cases were found in combination group during DC/CIK infusion. Conclusions: The maintenance treatment of NSCLC with pemetrexed combined with DC-CIK is a safe and effective method.
2016, 41(4): 485-487.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.019
Abstract:
Objective: To explore the serum levels change of Fractalkine, monocyte chemotactic protein-1(MCP-1) and interleukin-8(IL-8) in patients with coronary heart disease(CHD) and its significance. Methods: After coronary angiography, 48 stable angina patients, 56 unstable angina patients, 37 acute myocardial infarction(AMI) patients and 50 healthy people were divided into the SA, UA, AMI and control group, respectively. The serum levels of Fractalkine, MCP-1 and IL-8 in four groups were measured using enzyme-linked immunosorbent assay, and the severity of coronary artery disease was evaluated by Judkins method. Results: The serum levels of Fractalkine, MCP-1 and IL-8 in CHD patients were significantly higher than those in control group(P<0.01), and the serum levels of Fractalkine, MCP-1 and IL-8 in UA and AMI group were significantly higher than those in SA group(P<0.01). The serum levels of Fractalkine, MCP-1 and IL-8 in patients with double arteries and multiple arteries disease were significantly higher than those in patients with single artery disease(P<0.01). The serum levels of Fractalkine, MCP-1 and IL-8 in patients with severe stenosis and moderate stenosis were significantly higher than those in patients with mild stenosis(P<0.01). Conclusions: The CHD patient illness aggravates with the serum levels of Fractalkine, MCP-1 and IL-8 increasing, which can evaluate the severity and development of disease in CHD patients.
Objective: To explore the serum levels change of Fractalkine, monocyte chemotactic protein-1(MCP-1) and interleukin-8(IL-8) in patients with coronary heart disease(CHD) and its significance. Methods: After coronary angiography, 48 stable angina patients, 56 unstable angina patients, 37 acute myocardial infarction(AMI) patients and 50 healthy people were divided into the SA, UA, AMI and control group, respectively. The serum levels of Fractalkine, MCP-1 and IL-8 in four groups were measured using enzyme-linked immunosorbent assay, and the severity of coronary artery disease was evaluated by Judkins method. Results: The serum levels of Fractalkine, MCP-1 and IL-8 in CHD patients were significantly higher than those in control group(P<0.01), and the serum levels of Fractalkine, MCP-1 and IL-8 in UA and AMI group were significantly higher than those in SA group(P<0.01). The serum levels of Fractalkine, MCP-1 and IL-8 in patients with double arteries and multiple arteries disease were significantly higher than those in patients with single artery disease(P<0.01). The serum levels of Fractalkine, MCP-1 and IL-8 in patients with severe stenosis and moderate stenosis were significantly higher than those in patients with mild stenosis(P<0.01). Conclusions: The CHD patient illness aggravates with the serum levels of Fractalkine, MCP-1 and IL-8 increasing, which can evaluate the severity and development of disease in CHD patients.
2016, 41(4): 488-490.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.020
Abstract:
Objective: To investigate the clinical effects of the improved frontal sinus surgery under the nose hill guided by 0 degree mirror in the treatment of frontal sinus disease. Methods: One hundred and ten patients with frontal sinusitis were randomly divided into the observation group and control group(55 cases each group). The observation group were treated with the improved frontal sinus surgery under the nose hill guided by 0 degree mirror, the control group were treated with the conventional frontal sinus surgery. The operation condition, stress response, and short-term and long-term effects in two groups were compared. Results: The operation time and bleeding volume in observation group were less than those in control group(P<0.01), the levels of epinephrine, norepinephrine and angiotensin Ⅱ in observation group were significantly lower than those in control group(P<0.01). The short-term treatment effects and recurrence rate in observation group were significantly better and less than those in control group, respectively(P<0.05). The score of life quality in observation group was significantly higher than that in control group(P<0.01). Conclusions: The improved frontal sinus surgery under the nose hill guided by 0 degree mirror can reduce operation wound, promote postoperative recovery, relieve stress response and improve treatment effect.
Objective: To investigate the clinical effects of the improved frontal sinus surgery under the nose hill guided by 0 degree mirror in the treatment of frontal sinus disease. Methods: One hundred and ten patients with frontal sinusitis were randomly divided into the observation group and control group(55 cases each group). The observation group were treated with the improved frontal sinus surgery under the nose hill guided by 0 degree mirror, the control group were treated with the conventional frontal sinus surgery. The operation condition, stress response, and short-term and long-term effects in two groups were compared. Results: The operation time and bleeding volume in observation group were less than those in control group(P<0.01), the levels of epinephrine, norepinephrine and angiotensin Ⅱ in observation group were significantly lower than those in control group(P<0.01). The short-term treatment effects and recurrence rate in observation group were significantly better and less than those in control group, respectively(P<0.05). The score of life quality in observation group was significantly higher than that in control group(P<0.01). Conclusions: The improved frontal sinus surgery under the nose hill guided by 0 degree mirror can reduce operation wound, promote postoperative recovery, relieve stress response and improve treatment effect.
2016, 41(4): 491-492,495.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.021
Abstract:
Objective: To explore the clinical effects of rosuvastatin combined with nicergoline in the treatment of cognitive impairment after carotid stenosis. Methods: One hundred and eight patients with cognitive impairment after carotid stenosis were randomly divided into the observation group(55 cases) and control group(53 cases). The control and observation group were treated with nicergoline, and rosuvastatin combined with nicergoline respectively. The cognition and activities in two groups were evaluated using the Mini Mental State Examination(MMSE)table and activities of daily living(ADL)scale, the clinical effects between two groups were compared. Results: The differences of the MMSE and ADL scores in two groups were not statistically significant before treatment(P>0.05), the MMSE and ADL scores in two groups were significantly improved(P<0.01) and the increasing degree of the MMSE and ADL scores in observation group were significantly higher than those in control group after treatment(P<0.01). The clinical total effective rate in observation group(96.36%) was significantly better than that in control group(79.25%)(P<0.01). Conclusions: The treatment of cognitive impairment after carotid stenosis with rosuvastatin combined with nicergoline can effectively improve the cognitive function and activities of daily living. The treatment effects of rosuvastatin combined with nicergoline is significantly better than that of nicergoline, which is worthy of application in clinical.
Objective: To explore the clinical effects of rosuvastatin combined with nicergoline in the treatment of cognitive impairment after carotid stenosis. Methods: One hundred and eight patients with cognitive impairment after carotid stenosis were randomly divided into the observation group(55 cases) and control group(53 cases). The control and observation group were treated with nicergoline, and rosuvastatin combined with nicergoline respectively. The cognition and activities in two groups were evaluated using the Mini Mental State Examination(MMSE)table and activities of daily living(ADL)scale, the clinical effects between two groups were compared. Results: The differences of the MMSE and ADL scores in two groups were not statistically significant before treatment(P>0.05), the MMSE and ADL scores in two groups were significantly improved(P<0.01) and the increasing degree of the MMSE and ADL scores in observation group were significantly higher than those in control group after treatment(P<0.01). The clinical total effective rate in observation group(96.36%) was significantly better than that in control group(79.25%)(P<0.01). Conclusions: The treatment of cognitive impairment after carotid stenosis with rosuvastatin combined with nicergoline can effectively improve the cognitive function and activities of daily living. The treatment effects of rosuvastatin combined with nicergoline is significantly better than that of nicergoline, which is worthy of application in clinical.
2016, 41(4): 493-495.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.022
Abstract:
Objective: To investigate the risk factors of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) patients complicated with ventilator-associated pneumonia(VAP), and provide the basis for the clinical treatment of patients with AECOPD. Methods: The clinical data about the relationships of the occurrence of VAP and the general information (age, gender and body mass index), nutrition support route (enteral nutrition or total parenteral nutrition support), whether application of acid suppressive drugs, whether complicated with basic diseases, mechanical ventilation time in the 104 AECOPD patients were analyzed retrospectively. Results: The incidence of VAP was increased by total parenteral nutrition and combined with basic diseases(P<0.05 and P<0.01). There was no significant difference between the incidence of VAP and gender, age, body mass index, the application of acid suppressive drugs and the time of ventilator ventilation(P>0.05). The results of logistic regression analysis were shown that the total parenteral nutrition support and combination with basic diseases were the independent risk factors for VAP (P<0.05). Conclusions: There are many factors affecting the incidence of VAP in AECOPD patients, the basic diseases should be treated actively, and early enteral nutrition support should be done, to improve the prognosis of patients.
Objective: To investigate the risk factors of acute exacerbation of chronic obstructive pulmonary disease(AECOPD) patients complicated with ventilator-associated pneumonia(VAP), and provide the basis for the clinical treatment of patients with AECOPD. Methods: The clinical data about the relationships of the occurrence of VAP and the general information (age, gender and body mass index), nutrition support route (enteral nutrition or total parenteral nutrition support), whether application of acid suppressive drugs, whether complicated with basic diseases, mechanical ventilation time in the 104 AECOPD patients were analyzed retrospectively. Results: The incidence of VAP was increased by total parenteral nutrition and combined with basic diseases(P<0.05 and P<0.01). There was no significant difference between the incidence of VAP and gender, age, body mass index, the application of acid suppressive drugs and the time of ventilator ventilation(P>0.05). The results of logistic regression analysis were shown that the total parenteral nutrition support and combination with basic diseases were the independent risk factors for VAP (P<0.05). Conclusions: There are many factors affecting the incidence of VAP in AECOPD patients, the basic diseases should be treated actively, and early enteral nutrition support should be done, to improve the prognosis of patients.
2016, 41(4): 496-498,501.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.023
Abstract:
Objective: To observe the curative effects of three methods in the treatment of uterine scar pregnancy(CSP). Methods: One hundred and twenty patients with CSP were randomly divided into the methotrexate(MTX) group, embolization group and combination group(40 cases each group). The MTX group, embolization group and combination group were treated with MTX intravenous injection, gelatin sponge perfusion in uterine artery and combination with the above two methods, respectively. The levels of β-human chorionic gonadotrophin(β-hCG), intraoperative and postoperative hemorrhage volume, diameter of gestational sac after 7 days of treatment, hospitalization time and clinical efficacy and adverse reactions among three groups were compared. Results: The serum levels of β-hCG in combination group after 3 days and 7 days of treatment were obviously lower than those in embolization group and MTX group(P<0.01). The total hemorrhage volume in the combination group was obviously less than that in embolization group and MTX group(P<0.01). The diameter of gestational sac after 7 days of treatment was significantly smaller than that in embolization group and MTX group(P<0.01). The time of β-hCG level recovery and hospitalization in combination group were obviously shorter than those in embolization group and MTX group(P<0.01). The differences of clinical curative effects and adverse reactions among three groups were not statistically significant(P>0.05). Conclusions: The treatment of uterine scar pregnancy with MTX perfusion combined with embolization in uterine artery has good clinical effects, and the adverse reactions do not be increased.
Objective: To observe the curative effects of three methods in the treatment of uterine scar pregnancy(CSP). Methods: One hundred and twenty patients with CSP were randomly divided into the methotrexate(MTX) group, embolization group and combination group(40 cases each group). The MTX group, embolization group and combination group were treated with MTX intravenous injection, gelatin sponge perfusion in uterine artery and combination with the above two methods, respectively. The levels of β-human chorionic gonadotrophin(β-hCG), intraoperative and postoperative hemorrhage volume, diameter of gestational sac after 7 days of treatment, hospitalization time and clinical efficacy and adverse reactions among three groups were compared. Results: The serum levels of β-hCG in combination group after 3 days and 7 days of treatment were obviously lower than those in embolization group and MTX group(P<0.01). The total hemorrhage volume in the combination group was obviously less than that in embolization group and MTX group(P<0.01). The diameter of gestational sac after 7 days of treatment was significantly smaller than that in embolization group and MTX group(P<0.01). The time of β-hCG level recovery and hospitalization in combination group were obviously shorter than those in embolization group and MTX group(P<0.01). The differences of clinical curative effects and adverse reactions among three groups were not statistically significant(P>0.05). Conclusions: The treatment of uterine scar pregnancy with MTX perfusion combined with embolization in uterine artery has good clinical effects, and the adverse reactions do not be increased.
2016, 41(4): 499-501.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.024
Abstract:
Objective: To discuss the effects of early lactate clearance rate on the prognosis of patients with severe sepsis and septic shock. Methods: The lactic acid levels in 112 patients with severe sepsis and septic shock were measured at admission and at 6 hours of admission, and the lactate clearance rates of all cases were calculated. All patients were divided into the high lactate clearance rate group(the lactate clearance rate more than 10%) and low lactate clearance rate group(the lactate clearance rate less than 10%). The mortality, initial level of lactic acid and APACHE Ⅱ score between two groups were compared. All patients were followed up for 30 days, and divided into the survival group and death group according to their survival. The arterial blood lactate level, early lactate clearance rate and APACHE Ⅱ score between two groups were compared. Results: The difference of the initial level of lactic acid between the high lactate clearance rate group and low lactate clearance rate group was statistically significant(P<0.01). The mortality and APACHE Ⅱ score in high lactate clearance rate group were significantly lower than those in low lactate clearance rate group(P<0.01). Fifty-five cases died and 67 cases survived after 30 days of following up. The APACHE Ⅱ score in survival group was significantly lower than that in mortality group(P<0.01). The lactate clearance rate in survival group in the early period was significantly higher than that in mortality group(P<0.01). Conclusions: The early lactate clearance rate is an important index and more reliability in judging the prognosis of patients with severe sepsis and septic shock.
Objective: To discuss the effects of early lactate clearance rate on the prognosis of patients with severe sepsis and septic shock. Methods: The lactic acid levels in 112 patients with severe sepsis and septic shock were measured at admission and at 6 hours of admission, and the lactate clearance rates of all cases were calculated. All patients were divided into the high lactate clearance rate group(the lactate clearance rate more than 10%) and low lactate clearance rate group(the lactate clearance rate less than 10%). The mortality, initial level of lactic acid and APACHE Ⅱ score between two groups were compared. All patients were followed up for 30 days, and divided into the survival group and death group according to their survival. The arterial blood lactate level, early lactate clearance rate and APACHE Ⅱ score between two groups were compared. Results: The difference of the initial level of lactic acid between the high lactate clearance rate group and low lactate clearance rate group was statistically significant(P<0.01). The mortality and APACHE Ⅱ score in high lactate clearance rate group were significantly lower than those in low lactate clearance rate group(P<0.01). Fifty-five cases died and 67 cases survived after 30 days of following up. The APACHE Ⅱ score in survival group was significantly lower than that in mortality group(P<0.01). The lactate clearance rate in survival group in the early period was significantly higher than that in mortality group(P<0.01). Conclusions: The early lactate clearance rate is an important index and more reliability in judging the prognosis of patients with severe sepsis and septic shock.
2016, 41(4): 502-504.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.025
Abstract:
Objective: To investigate the effects of low molecular weight heparin on kallikrein level in patients with preeclampsia. Methods: Ninety-six patients with preeclampsia were divided into the observation group and control group by random number table method(48 cases each group). The control group were treated with conventional therapy, the observation group were additionally treated with 0.3 to 0.4 mL of low molecular weight heparin by subcutaneous injection based on the conventional therapy, once a day, up to before 12 to 24 h of delivery. The blood pressure, 24 h urine volume, urine protein quantity, blood platelet, coagulation function, maternal and neonatal outcomes and pregnancy outcome and kallikrein expression between the two groups were compared. Results: After the treatment, the systolic pressure, diastolic pressure and urine protein quantity in observation group were obviously lower than those in control group(P<0.01). The 24 h urine volume in observation group was obviously higher than that in control group(P<0.01). The differences of the blood platelet, fibrinogen, prothrombin time and thrombin time between two groups were not statistically significant after treatment(P>0.05). The D-dimer level in observation group was obviously lower than that in control group after treatment(P<0.01). The gestational age, neonatal birth weight and prolonged pregnancy time in observation group were obviously higher than those in control group after treatment(P<0.01). The kallikrein levels in the blood, placenta and urine in observation group were obviously higher than those in control group after treatment (P<0.01). Conclusions: The low molecular weight heparin can effectively enhance the kallikrein level in patients with preeclampsia, and improve the maternal and neonatal outcomes.
Objective: To investigate the effects of low molecular weight heparin on kallikrein level in patients with preeclampsia. Methods: Ninety-six patients with preeclampsia were divided into the observation group and control group by random number table method(48 cases each group). The control group were treated with conventional therapy, the observation group were additionally treated with 0.3 to 0.4 mL of low molecular weight heparin by subcutaneous injection based on the conventional therapy, once a day, up to before 12 to 24 h of delivery. The blood pressure, 24 h urine volume, urine protein quantity, blood platelet, coagulation function, maternal and neonatal outcomes and pregnancy outcome and kallikrein expression between the two groups were compared. Results: After the treatment, the systolic pressure, diastolic pressure and urine protein quantity in observation group were obviously lower than those in control group(P<0.01). The 24 h urine volume in observation group was obviously higher than that in control group(P<0.01). The differences of the blood platelet, fibrinogen, prothrombin time and thrombin time between two groups were not statistically significant after treatment(P>0.05). The D-dimer level in observation group was obviously lower than that in control group after treatment(P<0.01). The gestational age, neonatal birth weight and prolonged pregnancy time in observation group were obviously higher than those in control group after treatment(P<0.01). The kallikrein levels in the blood, placenta and urine in observation group were obviously higher than those in control group after treatment (P<0.01). Conclusions: The low molecular weight heparin can effectively enhance the kallikrein level in patients with preeclampsia, and improve the maternal and neonatal outcomes.
2016, 41(4): 505-507.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.026
Abstract:
Objective: To compare the effects of 3 kinds of different amount root canal filler in the treatment of dental pulp. Methods: One hundred and two patients(146 teeth) were treated with root canal filler. After treatment, these teeth were divided into the suitable supplement group(109 teeth), excessive supplement group(14 teeth) and deficient supplement group(23 teeth) according to the imaging data. The clinical effects and pain incidence between 3 groups were compared. Results: The total efficiency rare in suitable supplement group(94.50%) was significantly higher than that in excessive supplement group(64.29%) and deficient supplement group(47.83%)(P<0.01). The pain incidences in suitable supplement group, excessive supplement group and deficient supplement group were 3.67%, 14.29% and 26.09%, respectively, the differences of those between 3 groups were not statistically significant(P>0.05). Conclusions: Among the three kinds of different amount root canal filler, the treatment effect of suitable supplement is best, and the excessive and deficient supplement method should not be used in clinic.
Objective: To compare the effects of 3 kinds of different amount root canal filler in the treatment of dental pulp. Methods: One hundred and two patients(146 teeth) were treated with root canal filler. After treatment, these teeth were divided into the suitable supplement group(109 teeth), excessive supplement group(14 teeth) and deficient supplement group(23 teeth) according to the imaging data. The clinical effects and pain incidence between 3 groups were compared. Results: The total efficiency rare in suitable supplement group(94.50%) was significantly higher than that in excessive supplement group(64.29%) and deficient supplement group(47.83%)(P<0.01). The pain incidences in suitable supplement group, excessive supplement group and deficient supplement group were 3.67%, 14.29% and 26.09%, respectively, the differences of those between 3 groups were not statistically significant(P>0.05). Conclusions: Among the three kinds of different amount root canal filler, the treatment effect of suitable supplement is best, and the excessive and deficient supplement method should not be used in clinic.
2016, 41(4): 510-514.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.028
Abstract:
Objective: To investigate the trend of Chinese maternal mortality rate(MMR) and maternal health care utilization, and its relation for providing the reference in decreasing the MMR. Methods: The related data from China Health Statistics Year book and China maternal and child health monitoring report were collected to analyze the relationship between MMR and maternal health care utilization using grey correlation. Results: The MMR in 1994 to 2013 year declined from 64.8 to 23.2 each 100 thousand(decline for 64.2%), the decreasing degree of which in rural was higher than that in city. The morrhage and amniotic fluid embolism was the first and second cause of death. The maternal health care utilization increased, the increasing degree of which in rural was higher than that in city, the rise of hospital birth rate was the most quickly. The correlation analysis showed the MMR in rural was significantly negative correlation with 6 items of maternal health care utilization(P<0.01), the MMR in city was significantly negative correlation with the hospital birth rate(P<0.01). The difference of MMR in different area was a problem, the floating population was the focus of maternity care population. Conclusions: The decrease of maternal mortality rate in the last 20 years is significant. With the expanding of maternal health care utilization, the effect of increasing the hospital birth rate on the decreasing the MMR is limit, and new strategies and measures are needed.
Objective: To investigate the trend of Chinese maternal mortality rate(MMR) and maternal health care utilization, and its relation for providing the reference in decreasing the MMR. Methods: The related data from China Health Statistics Year book and China maternal and child health monitoring report were collected to analyze the relationship between MMR and maternal health care utilization using grey correlation. Results: The MMR in 1994 to 2013 year declined from 64.8 to 23.2 each 100 thousand(decline for 64.2%), the decreasing degree of which in rural was higher than that in city. The morrhage and amniotic fluid embolism was the first and second cause of death. The maternal health care utilization increased, the increasing degree of which in rural was higher than that in city, the rise of hospital birth rate was the most quickly. The correlation analysis showed the MMR in rural was significantly negative correlation with 6 items of maternal health care utilization(P<0.01), the MMR in city was significantly negative correlation with the hospital birth rate(P<0.01). The difference of MMR in different area was a problem, the floating population was the focus of maternity care population. Conclusions: The decrease of maternal mortality rate in the last 20 years is significant. With the expanding of maternal health care utilization, the effect of increasing the hospital birth rate on the decreasing the MMR is limit, and new strategies and measures are needed.
2016, 41(4): 515-517.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.029
Abstract:
Objective: To investigate the multi-slice spiral CT(MSCT) features of local infiltration in advanced colonic carcinoma. Methods: Thirty-one patients with advanced colonic carcinoma identified by histopathology were examined using the multi-slice spiral CT before operation. Compared with the histopathologic examination features, the preoperative imaging data in all cases were retrospectively analyzed. Results: Compared with the postoperative histopathological results of 31 cases with advanced colonic carcinoma, the multi-slice spiral CT imaging showed that bowel wall thickened, the intestinal fat gap had the cable or clouding high density imaging complicated with nodular and wedge-shaped shadow, which identified that the accuracy, sensitivity and specificity of local infiltration degree of tumor were 77.42, 22.58% & 80.65%, 37.50%, 13.04% &78.26%, and 91.3%, 50.00% & 87.50%, respectively, and the accuracy, sensitivity and specificity of lymph node metastses were 80.65%, 61.54% and 94.44%, respectively. Conclusions: The MSCT imaging of local infiltration in advanced colonic carcinoma show some special MSCT features, which can identify and evaluate the local infiltration degree of tumor, help to formulate the treatment protocol and predict prognosis.
Objective: To investigate the multi-slice spiral CT(MSCT) features of local infiltration in advanced colonic carcinoma. Methods: Thirty-one patients with advanced colonic carcinoma identified by histopathology were examined using the multi-slice spiral CT before operation. Compared with the histopathologic examination features, the preoperative imaging data in all cases were retrospectively analyzed. Results: Compared with the postoperative histopathological results of 31 cases with advanced colonic carcinoma, the multi-slice spiral CT imaging showed that bowel wall thickened, the intestinal fat gap had the cable or clouding high density imaging complicated with nodular and wedge-shaped shadow, which identified that the accuracy, sensitivity and specificity of local infiltration degree of tumor were 77.42, 22.58% & 80.65%, 37.50%, 13.04% &78.26%, and 91.3%, 50.00% & 87.50%, respectively, and the accuracy, sensitivity and specificity of lymph node metastses were 80.65%, 61.54% and 94.44%, respectively. Conclusions: The MSCT imaging of local infiltration in advanced colonic carcinoma show some special MSCT features, which can identify and evaluate the local infiltration degree of tumor, help to formulate the treatment protocol and predict prognosis.
Application of SWI in the analysis of the relationship between cerebral micorbleeds and hypertension
2016, 41(4): 518-521.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.030
Abstract:
Objective: To analyze the relationship between different types of cerebral microbleeds(CMBs) and hypertension. Methods: The data of cerebral susceptibility weighted imaging in 931 patients were retrospectively analyzed. Two hundred and twenty cases with hypertension and 711 cases without hypertension were identified. All patients were additionally scanned using susceptibility weighted imaging. Results: The differences of the detection rate of type Ⅰ, Ⅱ and Ⅴ CMBs between the hypertension group and non-hypertension group were statistically significant(P<0.05~P<0.01). The differences of the detection rate of type Ⅲ and Ⅳ CMBs between the hypertension group and non-hypertension group were not statistically significant(P>0.05). The differences of the constituent ratios of different types of CMBs between the hypertension group and non-hypertension group were not statistically significant(P>0.05). Conclusions: CMBs is more common in patients with hypertension, type Ⅰ, Ⅱ and Ⅴ CMBs are more common in patients with hypertension, and the differences of the detection rate of type Ⅲ and Ⅳ CMBs between the hypertension group and non-hypertension group is small. TypeⅠCMBs in hypertensive patients is mainly, followed by type Ⅴ, and typeⅠand typeⅡ CMBs are more in non-hypertensive patients.
Objective: To analyze the relationship between different types of cerebral microbleeds(CMBs) and hypertension. Methods: The data of cerebral susceptibility weighted imaging in 931 patients were retrospectively analyzed. Two hundred and twenty cases with hypertension and 711 cases without hypertension were identified. All patients were additionally scanned using susceptibility weighted imaging. Results: The differences of the detection rate of type Ⅰ, Ⅱ and Ⅴ CMBs between the hypertension group and non-hypertension group were statistically significant(P<0.05~P<0.01). The differences of the detection rate of type Ⅲ and Ⅳ CMBs between the hypertension group and non-hypertension group were not statistically significant(P>0.05). The differences of the constituent ratios of different types of CMBs between the hypertension group and non-hypertension group were not statistically significant(P>0.05). Conclusions: CMBs is more common in patients with hypertension, type Ⅰ, Ⅱ and Ⅴ CMBs are more common in patients with hypertension, and the differences of the detection rate of type Ⅲ and Ⅳ CMBs between the hypertension group and non-hypertension group is small. TypeⅠCMBs in hypertensive patients is mainly, followed by type Ⅴ, and typeⅠand typeⅡ CMBs are more in non-hypertensive patients.
2016, 41(4): 523-527.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.032
Abstract:
Objective: To construct the preparation method of the dissolving microneedle array(DMNA), and provide the basis for percutaneous release of macromolecular drugs. Methods: The metal master mold of DMNA was manufactured using computer-assisted micro-machining technique. The female mold was made from polydimethylsiloxane(PDMS), and charactered by scanning electron microscope(SEM). The preparation process of DMNA was optimized using carbopol as microneedle material. The mechanical properties of the optimized DMNAs were evaluated by using the rat skin in vitro. Results: The microneedle metal master mold was nicety. The SEM image of female mold showed that it was accurate, and consistent with the design. The DMNAs fabricated by optimized method had the same shape as mold, the microneedles can penetrate into the rat skin, and dissolve quickly. Conclusions: The new preparation method of the DMNA can provide the basis for percutaneous release of macromolecular drugs.
Objective: To construct the preparation method of the dissolving microneedle array(DMNA), and provide the basis for percutaneous release of macromolecular drugs. Methods: The metal master mold of DMNA was manufactured using computer-assisted micro-machining technique. The female mold was made from polydimethylsiloxane(PDMS), and charactered by scanning electron microscope(SEM). The preparation process of DMNA was optimized using carbopol as microneedle material. The mechanical properties of the optimized DMNAs were evaluated by using the rat skin in vitro. Results: The microneedle metal master mold was nicety. The SEM image of female mold showed that it was accurate, and consistent with the design. The DMNAs fabricated by optimized method had the same shape as mold, the microneedles can penetrate into the rat skin, and dissolve quickly. Conclusions: The new preparation method of the DMNA can provide the basis for percutaneous release of macromolecular drugs.
2016, 41(4): 527-530.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.033
Abstract:
Objective: To analyze the effects of the centerized bidding system of drug on the use of antibacterials in five county public hospitals in Anhui province. Methods: The purchasing varieties, distribution amount, defined daily dose system(DDDs) and DDC of antibacterials in five county public hospitals before and after the bidding were analyzed. Results: After bidding, except for monocyclic drug, the varieties, shipping amount and DDDs of antibacterials increased obviously. The categories of the top three drugs after bidding were cephalosporins, compound preparation and quinolones, respectively, which was the same as before bidding. The DDDs of clavulanate potassium injection ranked was the first before and after bidding. Among the top 10 ranking antibacterials in DDDs, the DDC in 8 kinds of drugs decreased after bidding. Conclusions: The centerized bidding system of drug reduces the DDC of many antibacterials, and improves the rational use of drugs. Improving the centerized bidding system can play a positive role in promoting the rational use of drugs in medical institutions.
Objective: To analyze the effects of the centerized bidding system of drug on the use of antibacterials in five county public hospitals in Anhui province. Methods: The purchasing varieties, distribution amount, defined daily dose system(DDDs) and DDC of antibacterials in five county public hospitals before and after the bidding were analyzed. Results: After bidding, except for monocyclic drug, the varieties, shipping amount and DDDs of antibacterials increased obviously. The categories of the top three drugs after bidding were cephalosporins, compound preparation and quinolones, respectively, which was the same as before bidding. The DDDs of clavulanate potassium injection ranked was the first before and after bidding. Among the top 10 ranking antibacterials in DDDs, the DDC in 8 kinds of drugs decreased after bidding. Conclusions: The centerized bidding system of drug reduces the DDC of many antibacterials, and improves the rational use of drugs. Improving the centerized bidding system can play a positive role in promoting the rational use of drugs in medical institutions.
2016, 41(4): 531-533.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.034
Abstract:
Objective: To investigate the vaccination quality of Bacillus Calmette-Guerin(BCG) in infants, analyze its related impacting factors and improve the effects of vaccination. Methods: The results of tuberculin(PPD) test in 1533 infants vaccinated with BCG and its related factors from Institute of Preventive Vaccination of Changzhou were analyzed, which was used to evaluate the quality of BCG vaccination. Results: The BCG scar rate and PPD positive rate were 94.59% and 96.09%, respectively. The differences of PPD positive rate in different gender, household register, birthweight and age were not statistically significant(P>0.05). The PPD positive rates in infants with 3 to 5 mm or more than 5 mm of BCG scar diameter were significantly higher than that in infants with less than 3 mm of BCG scar diameter(P<0.01). Conclusions: The quality of BCG vaccination is good, which meet the national immunization program criterion. The gender, household register, birthweight and age do not affect the PPD positive rate. Paying attention to the BCG quality and inoculation technique can significantly improve the inoculation effects.
Objective: To investigate the vaccination quality of Bacillus Calmette-Guerin(BCG) in infants, analyze its related impacting factors and improve the effects of vaccination. Methods: The results of tuberculin(PPD) test in 1533 infants vaccinated with BCG and its related factors from Institute of Preventive Vaccination of Changzhou were analyzed, which was used to evaluate the quality of BCG vaccination. Results: The BCG scar rate and PPD positive rate were 94.59% and 96.09%, respectively. The differences of PPD positive rate in different gender, household register, birthweight and age were not statistically significant(P>0.05). The PPD positive rates in infants with 3 to 5 mm or more than 5 mm of BCG scar diameter were significantly higher than that in infants with less than 3 mm of BCG scar diameter(P<0.01). Conclusions: The quality of BCG vaccination is good, which meet the national immunization program criterion. The gender, household register, birthweight and age do not affect the PPD positive rate. Paying attention to the BCG quality and inoculation technique can significantly improve the inoculation effects.
2016, 41(4): 534-536.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.035
Abstract:
Objective: To investigate the cognition of speciality and career intention of undergraduates in general practice(GP) medicine. Methods: The cognition of speciality and career intention of GP undergraduates from Bengbu Medical College were investigated using questionnaire survey. Results: One hundred and twenty(42.4%)GP students were willing to learn the general medicine-related courses, 104 students were satisfied with the teaching arrangement of GP. The proportions of students pursuing general practice medicine master's degree education and general practitioners participating the standardized training were 42.9% and 39.6%, respectively. One hundred and eight students were willing to be a general practitioner after graduation, the main reasons included 26(24.1%) students thinking the direction of general medicine as the future development direction, and 21(19.4%) students thinking job stability of general practitioner. The 30.6% of students were unwilling to be a general practitioner after graduation. The 23(30.7%) students thought that the income of general practitioner was low, and 19(25.3%) students thought that the social status of general practitioner was low. Conclusions: The cognition of speciality and career intention of undergraduates in general practice need to be further improved, national policies should tilt to general practitioner. Medical colleges should strengthen general practice education and guide students to plan career correctly.
Objective: To investigate the cognition of speciality and career intention of undergraduates in general practice(GP) medicine. Methods: The cognition of speciality and career intention of GP undergraduates from Bengbu Medical College were investigated using questionnaire survey. Results: One hundred and twenty(42.4%)GP students were willing to learn the general medicine-related courses, 104 students were satisfied with the teaching arrangement of GP. The proportions of students pursuing general practice medicine master's degree education and general practitioners participating the standardized training were 42.9% and 39.6%, respectively. One hundred and eight students were willing to be a general practitioner after graduation, the main reasons included 26(24.1%) students thinking the direction of general medicine as the future development direction, and 21(19.4%) students thinking job stability of general practitioner. The 30.6% of students were unwilling to be a general practitioner after graduation. The 23(30.7%) students thought that the income of general practitioner was low, and 19(25.3%) students thought that the social status of general practitioner was low. Conclusions: The cognition of speciality and career intention of undergraduates in general practice need to be further improved, national policies should tilt to general practitioner. Medical colleges should strengthen general practice education and guide students to plan career correctly.
2016, 41(4): 537-538.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.036
Abstract:
Objective: To understand the current situation of humanistic quality in medical students, to evaluate the gains and losses of humanistic quality education in the medical college and to put forward the improvement path. Methods: 'Humanistic quality of medical students developmental evaluation questionnaire' was adopted to investigate the students of grade one, grade three and grade five about the humanity quality evaluation indicators by using stratified cluster sampling survey. The assessment included 4 first class indicators, 10 second class indicators and 27 third class indicators. Results: The self-evaluation score of humanities quality indicators in the medical student of the three grades from high to low in turn were the humanistic spirit, humanistic thought, humanistic approach and humanity knowledge;and the difference was significant among the humanity knowledge, humanistic thought and humanistic approach(P<0.05 to P<0.01). The basic knowledge, executive ability and thinking acquired lower scores among the second class indicators. Conclusions: The humanistic quality education of the school is effective. But the school still needs to carry out targeted education to strengthen the students' humanistic knowledge, improve their information-processing and problem-solving ability and cultivate their innovative ideas and thinking.
Objective: To understand the current situation of humanistic quality in medical students, to evaluate the gains and losses of humanistic quality education in the medical college and to put forward the improvement path. Methods: 'Humanistic quality of medical students developmental evaluation questionnaire' was adopted to investigate the students of grade one, grade three and grade five about the humanity quality evaluation indicators by using stratified cluster sampling survey. The assessment included 4 first class indicators, 10 second class indicators and 27 third class indicators. Results: The self-evaluation score of humanities quality indicators in the medical student of the three grades from high to low in turn were the humanistic spirit, humanistic thought, humanistic approach and humanity knowledge;and the difference was significant among the humanity knowledge, humanistic thought and humanistic approach(P<0.05 to P<0.01). The basic knowledge, executive ability and thinking acquired lower scores among the second class indicators. Conclusions: The humanistic quality education of the school is effective. But the school still needs to carry out targeted education to strengthen the students' humanistic knowledge, improve their information-processing and problem-solving ability and cultivate their innovative ideas and thinking.
2016, 41(4): 539-542.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.037
Abstract:
Objective: To observe the effects of bundle nursing on decreasing deep venous thrombosis in tumor patients with peripherally inserted central catheter(PICC) catheterization. Methods: Sixty-four tumor patients with PICC in 2013(control group) were treated with conventional nursing, and 68 tumor patients in 2014(experimental group) were treated with bundle nursing. The occurrence of deep venous thrombosis in two groups were observed. Results: (1)The cephalic vein in 7 cases from the experimental group(10.3%) and 28 cases from control group(43.8%), and the basilic vein in 61 cases from the experimental group(89.3%) and 36 cases from control group(56.2%) were selected, the differences of the relationship between puncture vein and thrombosis were statistically significant(P<0.01). The thrombosis in cephalic vein catheterization of 1 case from the experimental group(14.2%) and 5 cases from control group(17.9%), and basilic vein of 1 case from the experimental group(14.2%) and 6 cases from control group(16.7%) were found, the differences of the thrombosis in two groups were statistically significant(P<0.05). (2) The thrombosis in 1 case from the experimental group(1.5%) and 8 cases from control group(12.5%) were found after 2 weeks of catheterization, the difference of which was statistically significant(P<0.01). The thrombosis in 3 cases from the experimental group(4.4%) and 10 cases from control group(15.6%) were found after 2 months of catheterization, the difference of which was statistically significant(P<0.05). The thrombosis in 3 cases from the experimental group(4.4%) and 12 cases from control group(18.8%) were found during the whole course of catheterization, the difference of which was statistically significant(P<0.01). (3) For locating catheter in place at one time, the thrombosis in 65 cases from the experimental group(95.5%) and 53 cases from control group(82.8%) were found, the difference of which was statistically significant(P<0.05). For locating catheter in place at two time, the thrombosis in 67 cases from the experimental group(98.5%) and 61 cases from control group(95.3%) were found, the difference of which was not statistically significant(P>0.05). After adjusting the location of catheer, the thrombosis in 1 case from the experimental group(1.5%) and 8 cases from control group(12.5%) were found, the difference of which was statistically significant(P<0.05). Conclusions: The bundle nursing can decrease the occurrence of deep venous thrombosis caused by PICC, which is worthy of promotion in clinic.
Objective: To observe the effects of bundle nursing on decreasing deep venous thrombosis in tumor patients with peripherally inserted central catheter(PICC) catheterization. Methods: Sixty-four tumor patients with PICC in 2013(control group) were treated with conventional nursing, and 68 tumor patients in 2014(experimental group) were treated with bundle nursing. The occurrence of deep venous thrombosis in two groups were observed. Results: (1)The cephalic vein in 7 cases from the experimental group(10.3%) and 28 cases from control group(43.8%), and the basilic vein in 61 cases from the experimental group(89.3%) and 36 cases from control group(56.2%) were selected, the differences of the relationship between puncture vein and thrombosis were statistically significant(P<0.01). The thrombosis in cephalic vein catheterization of 1 case from the experimental group(14.2%) and 5 cases from control group(17.9%), and basilic vein of 1 case from the experimental group(14.2%) and 6 cases from control group(16.7%) were found, the differences of the thrombosis in two groups were statistically significant(P<0.05). (2) The thrombosis in 1 case from the experimental group(1.5%) and 8 cases from control group(12.5%) were found after 2 weeks of catheterization, the difference of which was statistically significant(P<0.01). The thrombosis in 3 cases from the experimental group(4.4%) and 10 cases from control group(15.6%) were found after 2 months of catheterization, the difference of which was statistically significant(P<0.05). The thrombosis in 3 cases from the experimental group(4.4%) and 12 cases from control group(18.8%) were found during the whole course of catheterization, the difference of which was statistically significant(P<0.01). (3) For locating catheter in place at one time, the thrombosis in 65 cases from the experimental group(95.5%) and 53 cases from control group(82.8%) were found, the difference of which was statistically significant(P<0.05). For locating catheter in place at two time, the thrombosis in 67 cases from the experimental group(98.5%) and 61 cases from control group(95.3%) were found, the difference of which was not statistically significant(P>0.05). After adjusting the location of catheer, the thrombosis in 1 case from the experimental group(1.5%) and 8 cases from control group(12.5%) were found, the difference of which was statistically significant(P<0.05). Conclusions: The bundle nursing can decrease the occurrence of deep venous thrombosis caused by PICC, which is worthy of promotion in clinic.
2016, 41(4): 543-545.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.038
Abstract:
Objective: To investigate the effects of 5E rehabilitation model on anxiety, depression and knee function of patients with lower limb burn. Methods: Eighty-eight patients with lower limb burn were randomly divided into the observation group and control group(44 cases each group). The control group were nursed with routine rehabilitation measure. On this basis, the observation group were additionally nursed with 5E rehabilitation model(including encouragement, education, exercise, employment and evaluation). The anxiety, depression and knee function between two groups were compared. Results: The scores of the anxiety and depression in observation group were obviously lower than those in control group(P<0.01). The moderate and severe anxiety and depression rate in observation group were obviously lower than those in control group(P<0.01). The active and passive ranges of motion in observation group were obviously higher than those in control group(P<0.01). The scores of stair activity, functional independence measure and muscle force in observation group were obviously higher than those in control group(P<0.01). Conclusions: Compared with the routine rehabilitation model, the 5E rehabilitation model can effectively improve the anxiety and depression, range of joint motion and knee function in patients with lower limb burn.
Objective: To investigate the effects of 5E rehabilitation model on anxiety, depression and knee function of patients with lower limb burn. Methods: Eighty-eight patients with lower limb burn were randomly divided into the observation group and control group(44 cases each group). The control group were nursed with routine rehabilitation measure. On this basis, the observation group were additionally nursed with 5E rehabilitation model(including encouragement, education, exercise, employment and evaluation). The anxiety, depression and knee function between two groups were compared. Results: The scores of the anxiety and depression in observation group were obviously lower than those in control group(P<0.01). The moderate and severe anxiety and depression rate in observation group were obviously lower than those in control group(P<0.01). The active and passive ranges of motion in observation group were obviously higher than those in control group(P<0.01). The scores of stair activity, functional independence measure and muscle force in observation group were obviously higher than those in control group(P<0.01). Conclusions: Compared with the routine rehabilitation model, the 5E rehabilitation model can effectively improve the anxiety and depression, range of joint motion and knee function in patients with lower limb burn.
2016, 41(4): 546-549.
doi: 10.13898/j.cnki.issn.1000-2200.2016.04.039
Abstract:
Objective: To investigate the effects of psychological intervention on psychogenic behavior and life quality in early malignancy patients. Methods: Ninety-six early malignancy patients were randomly divided into the control group and experimental group. The control group were nursed with conventional measure, the experimental group were nursed with psychological intervention based on the conventional measures. The psychogenic behavior and life quality between two groups were compared before and after treatment. Results: The psychological and behavioral survey showed that the incidences of the despair, dependency, fear, depression and anxiety in experimental group were less than those in control group after treatment(P<0.05 to P<0.01). The QLQ-C30 showed that the postoperative functional scores in experimental group were significantly higher than those in control group(P<0.01), the scores of the fatigue, pain, sleep disorders, reduced appetite, constipation and diarrhea in experimental group were lower than those in control group(P<0.05 to P<0.01). The total score of quality of life in experimental group was significantly higher than that in control group(P<0.01). Conclusions: The negative psychological behavior is found in many early malignancy patients. The positive psychological intervention can effectively improve the psychological condition and quality of life.
Objective: To investigate the effects of psychological intervention on psychogenic behavior and life quality in early malignancy patients. Methods: Ninety-six early malignancy patients were randomly divided into the control group and experimental group. The control group were nursed with conventional measure, the experimental group were nursed with psychological intervention based on the conventional measures. The psychogenic behavior and life quality between two groups were compared before and after treatment. Results: The psychological and behavioral survey showed that the incidences of the despair, dependency, fear, depression and anxiety in experimental group were less than those in control group after treatment(P<0.05 to P<0.01). The QLQ-C30 showed that the postoperative functional scores in experimental group were significantly higher than those in control group(P<0.01), the scores of the fatigue, pain, sleep disorders, reduced appetite, constipation and diarrhea in experimental group were lower than those in control group(P<0.05 to P<0.01). The total score of quality of life in experimental group was significantly higher than that in control group(P<0.01). Conclusions: The negative psychological behavior is found in many early malignancy patients. The positive psychological intervention can effectively improve the psychological condition and quality of life.
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