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2017 Vol. 42, No. 12
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2017, 42(12): 1573-1575.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.001
Abstract:
Objective:To explore the specific cleavage activities of type 10-23 deoxyribozyme 10-23 DRz enzymes on HBV S and C RNA in vitro.Methods:The recombinant plasmids containing HBV S and C gene were constructed,respectively.The HBV S or C gene RNA was synthesized in vitro using the linearized recombinant plasmid as template.The DRz-hbvs-1 and DRz-hbvc-1 targeting to cleave HBV S and C mRNA were designed and synthesized,respectively,and the cleavage activities of which on targeting RNA were observed in vitro.Results:The DRz-hbvs-1 and DRz-hbvc-1 could specifically and effectively cleave the targeting RNA,and the cleavage of which in nonDRz and ASODN control groups were not found.Conclusions:The 10-23 DRz can specifically cleave the HBV S and C gene RNA in vitro.
Objective:To explore the specific cleavage activities of type 10-23 deoxyribozyme 10-23 DRz enzymes on HBV S and C RNA in vitro.Methods:The recombinant plasmids containing HBV S and C gene were constructed,respectively.The HBV S or C gene RNA was synthesized in vitro using the linearized recombinant plasmid as template.The DRz-hbvs-1 and DRz-hbvc-1 targeting to cleave HBV S and C mRNA were designed and synthesized,respectively,and the cleavage activities of which on targeting RNA were observed in vitro.Results:The DRz-hbvs-1 and DRz-hbvc-1 could specifically and effectively cleave the targeting RNA,and the cleavage of which in nonDRz and ASODN control groups were not found.Conclusions:The 10-23 DRz can specifically cleave the HBV S and C gene RNA in vitro.
2017, 42(12): 1576-1580.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.002
Abstract:
Objective:To observe the occurrence of myocardial fibrosis and the change of MMP-14 in different courses of diabetic rats and analyze the possible mechanism.Methods:All male Sprague Dawley(SD) rats were randomly divided into five groups(n=6):control group(CON),high glucose and high caloric group(HC) group and type 2 diabetes mellitus groups at 4-week(DM4w),8-week(DM8w) and 12-week(DM12w).Plasma triglyceride (TG),total cholesterol(TC) and fasting blood glucose (FBG) levels were measured,body weight (BW),the ratio of heart weight/body weight(H/B),left ventricular weight index(LVWI) levels were calculated.The myocardial morphological and fibrotic changes were discovered by HE and Masson staining methods.The contents of col Ⅰ and col Ⅲ in heart tissue were evaluated by ELISA and the ratio of colⅠ/col Ⅲ was calculated.The protein expressions of MMP-14 and col Ⅰ were measured by Western blotting.Results:Compared with CON group,plasma TG and TC levels increased significantly in HC and DM groups.The FBG level increased in DM groups.With the course of diabetes extended,FBG,H/B,LVWI and plasma TG and TC levels further increased.HE staining showed cardiac cells were arranged irregularly and fractures were not continuous in DM groups,Masson staining showed that a large amount of interstitial collagen fiber hyperplasia,collagen accumulation or uneven distribution appeared in DM groups.The contents of col Ⅰ,col Ⅲ,the ratio of col Ⅰ/col Ⅲ and the protein expressions of col Ⅰ and MMP-14 in myocardial tissue were further increased with the extension of diabetes course.Conclusions:Type 2 diabetes can induced the happening of myocardial fibrosis,the fibrosis degree will gradually aggravated with the course of diabetes extended.The mechanism may be related to the continuously increase of the expression of MMP-14 in myocardium.
Objective:To observe the occurrence of myocardial fibrosis and the change of MMP-14 in different courses of diabetic rats and analyze the possible mechanism.Methods:All male Sprague Dawley(SD) rats were randomly divided into five groups(n=6):control group(CON),high glucose and high caloric group(HC) group and type 2 diabetes mellitus groups at 4-week(DM4w),8-week(DM8w) and 12-week(DM12w).Plasma triglyceride (TG),total cholesterol(TC) and fasting blood glucose (FBG) levels were measured,body weight (BW),the ratio of heart weight/body weight(H/B),left ventricular weight index(LVWI) levels were calculated.The myocardial morphological and fibrotic changes were discovered by HE and Masson staining methods.The contents of col Ⅰ and col Ⅲ in heart tissue were evaluated by ELISA and the ratio of colⅠ/col Ⅲ was calculated.The protein expressions of MMP-14 and col Ⅰ were measured by Western blotting.Results:Compared with CON group,plasma TG and TC levels increased significantly in HC and DM groups.The FBG level increased in DM groups.With the course of diabetes extended,FBG,H/B,LVWI and plasma TG and TC levels further increased.HE staining showed cardiac cells were arranged irregularly and fractures were not continuous in DM groups,Masson staining showed that a large amount of interstitial collagen fiber hyperplasia,collagen accumulation or uneven distribution appeared in DM groups.The contents of col Ⅰ,col Ⅲ,the ratio of col Ⅰ/col Ⅲ and the protein expressions of col Ⅰ and MMP-14 in myocardial tissue were further increased with the extension of diabetes course.Conclusions:Type 2 diabetes can induced the happening of myocardial fibrosis,the fibrosis degree will gradually aggravated with the course of diabetes extended.The mechanism may be related to the continuously increase of the expression of MMP-14 in myocardium.
2017, 42(12): 1581-1584.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.003
Abstract:
Objective:To investigate the effects of ropivacaine on autophagy and autolysosomes in HeLa cells.Methods:The HeLa,HeLa-GFP-LC3 and HeLa-RFP-LAMP1 cell lines were divided into the blank control group,starvation group(starving for 0,4 and 12 hours) and ropivacaine group(10 mg/mL ropivacaine treating for 0,4 and 12 hours).The induction of autophagy,morphology of autolysosomes and numbers of lysosomes in HeLa,HeLa-GFP-LC3 and HeLa-RFP-LAMP1 cell lines treated with ropivacaine were detected using the microscopic imaging technique combined with a variety of biochemical means.Results:Compared with the blank control cells,the LC3 puncta and LC3Ⅱ protein level significantly increased in ropivacaine group(P<0.05).Compared with the blank control cells,many autolysosomes in ropivacaine group and starvation group were identified after 4 hours of treatment,and the autolysosomes size in ropivacaine group was bigger than that in starvation group.The number of lysosomes in starvation group began to reduce at 4 hours of treatment,and recovered at 12 hours of treatment,but which in ropivacaine group gradually decreased and could not recover in HeLa cells.Conclusions:Ropivacaine can induce the autophagy,and damage autolysosomes.
Objective:To investigate the effects of ropivacaine on autophagy and autolysosomes in HeLa cells.Methods:The HeLa,HeLa-GFP-LC3 and HeLa-RFP-LAMP1 cell lines were divided into the blank control group,starvation group(starving for 0,4 and 12 hours) and ropivacaine group(10 mg/mL ropivacaine treating for 0,4 and 12 hours).The induction of autophagy,morphology of autolysosomes and numbers of lysosomes in HeLa,HeLa-GFP-LC3 and HeLa-RFP-LAMP1 cell lines treated with ropivacaine were detected using the microscopic imaging technique combined with a variety of biochemical means.Results:Compared with the blank control cells,the LC3 puncta and LC3Ⅱ protein level significantly increased in ropivacaine group(P<0.05).Compared with the blank control cells,many autolysosomes in ropivacaine group and starvation group were identified after 4 hours of treatment,and the autolysosomes size in ropivacaine group was bigger than that in starvation group.The number of lysosomes in starvation group began to reduce at 4 hours of treatment,and recovered at 12 hours of treatment,but which in ropivacaine group gradually decreased and could not recover in HeLa cells.Conclusions:Ropivacaine can induce the autophagy,and damage autolysosomes.
2017, 42(12): 1585-1588.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.004
Abstract:
Objective:To establish the osteoarthritis model by medial meniscus partial resection combined with anterior cruciate ligament transecting,and observe the pathological changes of knee joint in rats.Methods:Twenty female SD rats were implemented with medial meniscus partial resection combined with anterior cruciate ligament transecting in right knee joint,and the left side was set as the control.The whole knee joint was harvested after 1,2,4,6 and 8 weeks of operation,and the knee morphology,joint cartilage structure,synovial ED1-positive cells and X-ray image in knee joints were observed.Results:After 1 week of operation,cartilage cellular swelling,superficial cartilage cells death and decreasing,superficial fibrosis and number of monoclonal antibody ED1 positive cells in synovium increasing were detected.After 4 weeks of operation,the total knee morphological change,bone density under cartilage increasing and synovial hyperfibrosis were observed.Conclusions:The medial meniscus partial resection combined with anterior cruciate ligament transecting can early induce the pathological changes of OA,which is an ideal animal model in osteoarthritis study.
Objective:To establish the osteoarthritis model by medial meniscus partial resection combined with anterior cruciate ligament transecting,and observe the pathological changes of knee joint in rats.Methods:Twenty female SD rats were implemented with medial meniscus partial resection combined with anterior cruciate ligament transecting in right knee joint,and the left side was set as the control.The whole knee joint was harvested after 1,2,4,6 and 8 weeks of operation,and the knee morphology,joint cartilage structure,synovial ED1-positive cells and X-ray image in knee joints were observed.Results:After 1 week of operation,cartilage cellular swelling,superficial cartilage cells death and decreasing,superficial fibrosis and number of monoclonal antibody ED1 positive cells in synovium increasing were detected.After 4 weeks of operation,the total knee morphological change,bone density under cartilage increasing and synovial hyperfibrosis were observed.Conclusions:The medial meniscus partial resection combined with anterior cruciate ligament transecting can early induce the pathological changes of OA,which is an ideal animal model in osteoarthritis study.
2017, 42(12): 1589-1592.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.005
Abstract:
Objective:To explore the expression levels of miRNA-101 in gastric cancer tissue and cell,and its influence on biological behavior of gastric cancer cells.Methods:The expression levels of miRNA-101 in 31 gastric carcinoma tissue and paraneoplastic tissue samples,human gastric carcinoma cell line SGC-7901 and MKN45,and normal human gastric epithelial cell line GES1 were detected using real-time PCR method.The recombinant adenovirus vector containing miRNA-101 was established,and transfected into the gastric cancer cell line SGC-7901 and MKN45.The effect of miRNA-101 on gastric cancer cell proliferation was detected by MTT method,and the migration and invasion of gastric cancer cells were detected by Transwell method.Results:The expression level of miRNA-101 in gastric cancer tissue was significantly lower than that in adjacent tissue(P<0.01).The expression levels of miRNA-101 in SGC-7901 and MKN45 cell lines were significantly lower than that in GES1 cells(P<0.01).The proliferation of MKN45 cells in miRNA-101 group after 48 h of incubation was significantly lower than that in control group(P<0.05).The proliferations of SGC-7901 and MKN45 cells in miRNA-101 group after 72 h of incubation were lower than that in control group(P<0.05).The migration test results showed that the average migrated number of SGC-7901 and MKN45 cells in miRNA-101 group were significantly lower than that in control group(P<0.01).The invasion test results showed that the average invaded number of SGC-7901 and MKN45 cells in miRNA-101 group were significantly lower than that in control group(P<0.01).Conclusions:The expression levels of miRNA-101 in gastric cancer tissue and gastric cancer cell lines downregulate,the transfection of miRNA-101 can significantly decrease the abilities of proliferation,migration and invasion of SGC-7901 and MKN45 cells.The miRNA-101 may be involved in the occurrence and development of gastric diseases.
Objective:To explore the expression levels of miRNA-101 in gastric cancer tissue and cell,and its influence on biological behavior of gastric cancer cells.Methods:The expression levels of miRNA-101 in 31 gastric carcinoma tissue and paraneoplastic tissue samples,human gastric carcinoma cell line SGC-7901 and MKN45,and normal human gastric epithelial cell line GES1 were detected using real-time PCR method.The recombinant adenovirus vector containing miRNA-101 was established,and transfected into the gastric cancer cell line SGC-7901 and MKN45.The effect of miRNA-101 on gastric cancer cell proliferation was detected by MTT method,and the migration and invasion of gastric cancer cells were detected by Transwell method.Results:The expression level of miRNA-101 in gastric cancer tissue was significantly lower than that in adjacent tissue(P<0.01).The expression levels of miRNA-101 in SGC-7901 and MKN45 cell lines were significantly lower than that in GES1 cells(P<0.01).The proliferation of MKN45 cells in miRNA-101 group after 48 h of incubation was significantly lower than that in control group(P<0.05).The proliferations of SGC-7901 and MKN45 cells in miRNA-101 group after 72 h of incubation were lower than that in control group(P<0.05).The migration test results showed that the average migrated number of SGC-7901 and MKN45 cells in miRNA-101 group were significantly lower than that in control group(P<0.01).The invasion test results showed that the average invaded number of SGC-7901 and MKN45 cells in miRNA-101 group were significantly lower than that in control group(P<0.01).Conclusions:The expression levels of miRNA-101 in gastric cancer tissue and gastric cancer cell lines downregulate,the transfection of miRNA-101 can significantly decrease the abilities of proliferation,migration and invasion of SGC-7901 and MKN45 cells.The miRNA-101 may be involved in the occurrence and development of gastric diseases.
2017, 42(12): 1593-1596.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.006
Abstract:
Objective:To investigate the clinical value of national early warning score(NEWS) in the shunting and predicting short-term outcome of emergency patients.Methods:The NEWS in 803 patients in emergency resuscitation room were investigated according to the initial vital signs.The patients were divided into the outpatient group,general ward group and intensive care unit group according to the emergency shutting.The inhospital patients were divided into the survival group and death group according to the improvement.The NEWS between all groups were compared,and the correlations of age and NEWS with death rate of patients were analyzed.Results:Among 803 patients,the outpatient group in 145 cases,general ward group in 481 cases and intensive care unit group in 177 cases were identified,the NEWS in general ward group and intensive care unit group were significantly higher than that in outpatient group(P<0.01),and the NEWS in intensive care unit group was higher than that in general ward group(P<0.01).Six hundred and fifty-eight cases were further treated after inhospital,the outhospital was set as the observation end,the survival in 585 cases and death in 73 cases were found,the difference of the age between two groups was not statistical significance(P>0.05),and the NEWS in survival group was significantly lower than that in death group(P<0.01).The results of binary logistic showed that the NEWS was positive correlation with the death rate of patients,whereas the age was not correlated with the death rate of patients(P>0.05).Conclusions:The NEWS has crucial clinical value in the shunting and predicting short-term outcome of emergency patients.
Objective:To investigate the clinical value of national early warning score(NEWS) in the shunting and predicting short-term outcome of emergency patients.Methods:The NEWS in 803 patients in emergency resuscitation room were investigated according to the initial vital signs.The patients were divided into the outpatient group,general ward group and intensive care unit group according to the emergency shutting.The inhospital patients were divided into the survival group and death group according to the improvement.The NEWS between all groups were compared,and the correlations of age and NEWS with death rate of patients were analyzed.Results:Among 803 patients,the outpatient group in 145 cases,general ward group in 481 cases and intensive care unit group in 177 cases were identified,the NEWS in general ward group and intensive care unit group were significantly higher than that in outpatient group(P<0.01),and the NEWS in intensive care unit group was higher than that in general ward group(P<0.01).Six hundred and fifty-eight cases were further treated after inhospital,the outhospital was set as the observation end,the survival in 585 cases and death in 73 cases were found,the difference of the age between two groups was not statistical significance(P>0.05),and the NEWS in survival group was significantly lower than that in death group(P<0.01).The results of binary logistic showed that the NEWS was positive correlation with the death rate of patients,whereas the age was not correlated with the death rate of patients(P>0.05).Conclusions:The NEWS has crucial clinical value in the shunting and predicting short-term outcome of emergency patients.
2017, 42(12): 1596-1598.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.007
Abstract:
Objective:To investigate the effects of trichostatin A(TSA) on the expression of type Ⅰ Collagen in the scarring cytology model after glaucoma filtering surgery(GFS).Methods:The cytology model of scarring after GFS was established.The effects of 600 nmol/L TSA on the expression levels of type Ⅰ Collagen mRNA and protein were detected using RT-PCR and Western blotting,respectively.Results:The results of RT-PCR and Western blotting showed that the 600 nmol/L TSA could inhibit the expression levels of type Ⅰ Collagen mRNA and protein(P<0.01 and P<0.05).Conclusions:TSA can reduce the expression levels of type Ⅰ Collagen mRNA and protein in the scarring cytology model after GFS.
Objective:To investigate the effects of trichostatin A(TSA) on the expression of type Ⅰ Collagen in the scarring cytology model after glaucoma filtering surgery(GFS).Methods:The cytology model of scarring after GFS was established.The effects of 600 nmol/L TSA on the expression levels of type Ⅰ Collagen mRNA and protein were detected using RT-PCR and Western blotting,respectively.Results:The results of RT-PCR and Western blotting showed that the 600 nmol/L TSA could inhibit the expression levels of type Ⅰ Collagen mRNA and protein(P<0.01 and P<0.05).Conclusions:TSA can reduce the expression levels of type Ⅰ Collagen mRNA and protein in the scarring cytology model after GFS.
2017, 42(12): 1599-1600,1603.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.008
Abstract:
Objective:To analyze the serum level of uric acid(UA) in patients with cerebral infarction,and explore the relationship between the serum UA and cerebral infarction.Methods:Four hundred cerebral infarction patients were divided into the low serum UA group,normal serum UA group and high serum UA group.The serum levels of UA,low density lipoprotein cholesterin,triglyceride,total cholesterol and C-reactive protein were analyzed in three groups.The relationships between the serum levels of UA and degree of nervous functional defect between three groups were compared.Results:The differences of the levels of triglycerides,total cholesterol and low density lipoprotein cholesterin between three group were not statistically significant(P>0.05).With the increasing of the serum level of UA,the degree of nervous functional defect significantly decreased(P<0.01).Conclusions:High serum UA level can play a protection effect on severe neurologic deficit in cerebral infarction patients.
Objective:To analyze the serum level of uric acid(UA) in patients with cerebral infarction,and explore the relationship between the serum UA and cerebral infarction.Methods:Four hundred cerebral infarction patients were divided into the low serum UA group,normal serum UA group and high serum UA group.The serum levels of UA,low density lipoprotein cholesterin,triglyceride,total cholesterol and C-reactive protein were analyzed in three groups.The relationships between the serum levels of UA and degree of nervous functional defect between three groups were compared.Results:The differences of the levels of triglycerides,total cholesterol and low density lipoprotein cholesterin between three group were not statistically significant(P>0.05).With the increasing of the serum level of UA,the degree of nervous functional defect significantly decreased(P<0.01).Conclusions:High serum UA level can play a protection effect on severe neurologic deficit in cerebral infarction patients.
2017, 42(12): 1601-1603.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.009
Abstract:
Objective:To investigate the effects of mycophenolate mofetil combined with Ginkgo dipyridolum injection in the treatment of refractory nephropathy syndrome.Methods:Ninety-one patients with refractory nephropathy syndrome were randomly divided into the observation group(n=46) and control group(n=45) according to random number table.Two groups were treated with routine method at admission.The control group was treated with mycophenolate mofetil,and the observation group was additionally treated with Ginkgo dipyridolum injection on the basis of control group for 12 months.The clinical efficacy between two groups was compared.The levels of urine protein,blood urea nitrogen,creatinine and transforming growth factor-β before and after treatment,and adverse reaction during treatment course in two groups were observed.Results:The total effective rate in observation group(82.61%) was significantly higher than that in control group(62.22%) (P<0.01).After treatment,the levels of urine protein,blood urea nitrogen,creatinine and transforming growth factor-β in two groups significantly decreased(P<0.01),which in observation group was significantly lower than that in control group(P<0.01).There was not serious adverse reaction during the treatment course.Conclusions:Mycophenolate mofetil combined with Ginkgo dipyridolum injection can significantly decrease the levels of urine protein,blood urea nitrogen,creatinine and transforming growth factor-β,and improve the renal function in patients with refractory nephropathy syndrome,which is effective,safe and reliable.
Objective:To investigate the effects of mycophenolate mofetil combined with Ginkgo dipyridolum injection in the treatment of refractory nephropathy syndrome.Methods:Ninety-one patients with refractory nephropathy syndrome were randomly divided into the observation group(n=46) and control group(n=45) according to random number table.Two groups were treated with routine method at admission.The control group was treated with mycophenolate mofetil,and the observation group was additionally treated with Ginkgo dipyridolum injection on the basis of control group for 12 months.The clinical efficacy between two groups was compared.The levels of urine protein,blood urea nitrogen,creatinine and transforming growth factor-β before and after treatment,and adverse reaction during treatment course in two groups were observed.Results:The total effective rate in observation group(82.61%) was significantly higher than that in control group(62.22%) (P<0.01).After treatment,the levels of urine protein,blood urea nitrogen,creatinine and transforming growth factor-β in two groups significantly decreased(P<0.01),which in observation group was significantly lower than that in control group(P<0.01).There was not serious adverse reaction during the treatment course.Conclusions:Mycophenolate mofetil combined with Ginkgo dipyridolum injection can significantly decrease the levels of urine protein,blood urea nitrogen,creatinine and transforming growth factor-β,and improve the renal function in patients with refractory nephropathy syndrome,which is effective,safe and reliable.
2017, 42(12): 1604-1608.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.010
Abstract:
Objective:To investigate the effects of entecavir(ETV) in the treatment of chronic hepatitis B(CHB) virus infection,and its influencing factors for providing the basis in rational selection of antiviral drugs.Methods:A total of 79 patients with CHB virus infection were treated with 0.5 mg/d ETV by oral from August 2014 to February 2015.The liver function,HBV-DNA and hepatitis B two and half test were detected every three months.Results:After 12,24 and 48 weeks of treatment,the HBV-DNA negative percentage(<500 copies/mL) in patients was 45.6%,60.8% and 81.0%,respectively,the alanine aminotransferase(ALT) normalization rate were 67.24%,86.20% and 96.55%,respectively,and the HBV-DNA negative percentage and ALT normalization rate increased with the time increasing(P<0.01).The treatment history,cirrhosis,HBeAg level and baseline level of HBV-DNA were related to the HBV-DNA negative percentage(P<0.05 to P<0.01).After 12 weeks of treatment,the HBV-DNA negative percentage at initial treatment group and treated group was 52.3% and 14.3%,respectively(P<0.05),and the differences of which in two groups at 24 weeks and 48 weeks of treatment were not statistically significant(P>0.05).At 12,24 and 48 weeks of treatment,the HBV-DNA negative percentage in noncirrhosis patients with HBV-DNA ≤ 7.00log10 copies/mL were higher than that in cirrhosis patients with HBV-DNA >7.00log10 copies/mL(P<0.05 to P<0.01).At 12 weeks and 24 weeks of treatment,the HBV-DNA negative percentage in patients with HBeAg(-) was higher than that in patients with HBeAg(+)(P<0.05 to P<0.01),and the difference of which in two groups at 48 weeks of treatment was not statistically significant(P>0.05).No obvious adverse reaction,viral breakthrough and rebound were found in 79 patients during the following up period.Conclusions:The effect of ETV in the treatment of CHB virus infection is significant and with rare adverse reactions.Initial treatment and HBeAg status have significant effect on the early efficacy of ETV in treating HBV infection,but which has not significant effect on the long-term outcome.Noncirrhosis and HBV-DNA ≤ 7.00log10 copies/mL have some effects on long-term therapy,which can provide the evidence of predicting prognosis.
Objective:To investigate the effects of entecavir(ETV) in the treatment of chronic hepatitis B(CHB) virus infection,and its influencing factors for providing the basis in rational selection of antiviral drugs.Methods:A total of 79 patients with CHB virus infection were treated with 0.5 mg/d ETV by oral from August 2014 to February 2015.The liver function,HBV-DNA and hepatitis B two and half test were detected every three months.Results:After 12,24 and 48 weeks of treatment,the HBV-DNA negative percentage(<500 copies/mL) in patients was 45.6%,60.8% and 81.0%,respectively,the alanine aminotransferase(ALT) normalization rate were 67.24%,86.20% and 96.55%,respectively,and the HBV-DNA negative percentage and ALT normalization rate increased with the time increasing(P<0.01).The treatment history,cirrhosis,HBeAg level and baseline level of HBV-DNA were related to the HBV-DNA negative percentage(P<0.05 to P<0.01).After 12 weeks of treatment,the HBV-DNA negative percentage at initial treatment group and treated group was 52.3% and 14.3%,respectively(P<0.05),and the differences of which in two groups at 24 weeks and 48 weeks of treatment were not statistically significant(P>0.05).At 12,24 and 48 weeks of treatment,the HBV-DNA negative percentage in noncirrhosis patients with HBV-DNA ≤ 7.00log10 copies/mL were higher than that in cirrhosis patients with HBV-DNA >7.00log10 copies/mL(P<0.05 to P<0.01).At 12 weeks and 24 weeks of treatment,the HBV-DNA negative percentage in patients with HBeAg(-) was higher than that in patients with HBeAg(+)(P<0.05 to P<0.01),and the difference of which in two groups at 48 weeks of treatment was not statistically significant(P>0.05).No obvious adverse reaction,viral breakthrough and rebound were found in 79 patients during the following up period.Conclusions:The effect of ETV in the treatment of CHB virus infection is significant and with rare adverse reactions.Initial treatment and HBeAg status have significant effect on the early efficacy of ETV in treating HBV infection,but which has not significant effect on the long-term outcome.Noncirrhosis and HBV-DNA ≤ 7.00log10 copies/mL have some effects on long-term therapy,which can provide the evidence of predicting prognosis.
2017, 42(12): 1609-1611.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.011
Abstract:
Objective:To observe the effects of the different first doses of poractant alfa injection in the treatment of neonatal respiratory distress syndrome(NRDS) in premature infants.Methods:Eighty-one premature infants(gestational age < 37 weeks) with NRDS were divided into the high dose group(29 cases),medium dose group(25 cases) and low dose group(27 cases),and treated with 200,150 and 100 mg/kg poractant alfa injection combined with appropriate symptomatic support treatment,respectively.Results:The significant improvement of chest film,and levels of PaO2 and PaCO2 in high dose group was significantly higher that in medium and low dose groups(P<0.01),and the average mechanical ventilation time and oxygen cure time in high dose group were lower than those in medium and low dose groups(P<0.05 to P<0.01).The differences of the total incidence rates of patent ductus arteriosus,severe infection,intracranial hemorrhage,death and giving up treatment between three groups were statistically significant(P<0.01),and which in high dose group,medium dose group and low dose group gradually decreased in turn.Conclusions:The 200 mg/kg poractant alfa injection in the treatment of NRDS in premature infants can significantly improve the chest film and arterial blood gas analysis,shorten the mechanical ventilation time and oxygen therapy time,and is worthy of promotion in clinic.
Objective:To observe the effects of the different first doses of poractant alfa injection in the treatment of neonatal respiratory distress syndrome(NRDS) in premature infants.Methods:Eighty-one premature infants(gestational age < 37 weeks) with NRDS were divided into the high dose group(29 cases),medium dose group(25 cases) and low dose group(27 cases),and treated with 200,150 and 100 mg/kg poractant alfa injection combined with appropriate symptomatic support treatment,respectively.Results:The significant improvement of chest film,and levels of PaO2 and PaCO2 in high dose group was significantly higher that in medium and low dose groups(P<0.01),and the average mechanical ventilation time and oxygen cure time in high dose group were lower than those in medium and low dose groups(P<0.05 to P<0.01).The differences of the total incidence rates of patent ductus arteriosus,severe infection,intracranial hemorrhage,death and giving up treatment between three groups were statistically significant(P<0.01),and which in high dose group,medium dose group and low dose group gradually decreased in turn.Conclusions:The 200 mg/kg poractant alfa injection in the treatment of NRDS in premature infants can significantly improve the chest film and arterial blood gas analysis,shorten the mechanical ventilation time and oxygen therapy time,and is worthy of promotion in clinic.
2017, 42(12): 1612-1614.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.012
Abstract:
Objective:To explore the epidemiological and clinical characteristics of thyroid nodules(TN).Methods:The clinical data and postoperative pathology results in 3 958 TN cases were retrospectively analyzed.Results:The number of TN cases gradually increased from 2008 to 2013,which was 296,404,542,709,921 and 1 089 cases,respectively,the ratio of male to female was about 1:5,1 579 cases(39.9%) located the right side,3 185 cases(80.5%) were benign nodules and 773 cases(19.5%) were malignant nodules,the age ranged from 41 to 50 years old.Among the thyroid carcinoma(TC),the papillary carcinoma in 503 cases(12.7%),microcarcinoma in 126 cases(3.2%),follicular carcinoma in 11 cases(0.3%),anaplastic carcinoma in 11 cases(0.3%),mixed carcinoma in 11 cases(0.3%) and medullary carcinoma in 36 cases(0.9%) were found.Logistic regression analysis showed that the female,elder(30 to 60 years old),short disease course(<1 month),occupation,nodule size(≤ 2 cm) and nodal calcification were the risk factors of TC.Conclusions:The prevalence of TN increases year by year,the 41 to 50 years old female is high-risk group of TC.The age,course of disease,nodule size,calcification and occupation are related to the TC.
Objective:To explore the epidemiological and clinical characteristics of thyroid nodules(TN).Methods:The clinical data and postoperative pathology results in 3 958 TN cases were retrospectively analyzed.Results:The number of TN cases gradually increased from 2008 to 2013,which was 296,404,542,709,921 and 1 089 cases,respectively,the ratio of male to female was about 1:5,1 579 cases(39.9%) located the right side,3 185 cases(80.5%) were benign nodules and 773 cases(19.5%) were malignant nodules,the age ranged from 41 to 50 years old.Among the thyroid carcinoma(TC),the papillary carcinoma in 503 cases(12.7%),microcarcinoma in 126 cases(3.2%),follicular carcinoma in 11 cases(0.3%),anaplastic carcinoma in 11 cases(0.3%),mixed carcinoma in 11 cases(0.3%) and medullary carcinoma in 36 cases(0.9%) were found.Logistic regression analysis showed that the female,elder(30 to 60 years old),short disease course(<1 month),occupation,nodule size(≤ 2 cm) and nodal calcification were the risk factors of TC.Conclusions:The prevalence of TN increases year by year,the 41 to 50 years old female is high-risk group of TC.The age,course of disease,nodule size,calcification and occupation are related to the TC.
2017, 42(12): 1615-1617.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.013
Abstract:
Objective:To analyze the effects of different doses of donepezil combined with olanzapine on cognitive function and mental symptoms of patients with Alzheimer's disease(AD),and provide the guidance in clinical medication.Methods:Ninety-five patients with AD from January 2010 to December 2015 were divided into the observation group and control group according to the random number table method.The observation group and control group were treated with olanzapine combined with 10 mg/d and 5 mg/d donepezil by oral for 6 months,respectively.Results:The differences of the scores of NPI and MMS,and degree of care distress between two groups before treatment were not statistically significant(P>0.05).After 6 months of treatment,the scores of NPI and MMSE,and degree of care distress in observation group were better than those in control group(P<0.01),and which after treatment was significantly better than that before treatment in two groups(P<0.01).The scores of high emotion,apathy,hallucination,delusion,irritability and uncontrollable behavior in observation group were significantly better than those in control group(P<0.01).Conclusions:The 10 mg/d donepezil combined with olanzapine can effectively improve the psychiatric symptoms and cognitive function of patients with AD.
Objective:To analyze the effects of different doses of donepezil combined with olanzapine on cognitive function and mental symptoms of patients with Alzheimer's disease(AD),and provide the guidance in clinical medication.Methods:Ninety-five patients with AD from January 2010 to December 2015 were divided into the observation group and control group according to the random number table method.The observation group and control group were treated with olanzapine combined with 10 mg/d and 5 mg/d donepezil by oral for 6 months,respectively.Results:The differences of the scores of NPI and MMS,and degree of care distress between two groups before treatment were not statistically significant(P>0.05).After 6 months of treatment,the scores of NPI and MMSE,and degree of care distress in observation group were better than those in control group(P<0.01),and which after treatment was significantly better than that before treatment in two groups(P<0.01).The scores of high emotion,apathy,hallucination,delusion,irritability and uncontrollable behavior in observation group were significantly better than those in control group(P<0.01).Conclusions:The 10 mg/d donepezil combined with olanzapine can effectively improve the psychiatric symptoms and cognitive function of patients with AD.
2017, 42(12): 1618-1620,1623.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.014
Abstract:
Objective:To observe the effects of the nasal continuous positive airway pressure(CPAP) combined with small dose of corticosteroid on the blood gas index and inflammatory cytokine level in children with severe pneumonia.Methods:Seventy-eight children with severe pneumonia were divided into the observation group and control group according to the different treatment(39 cases each group).Two groups were treated with the conventional PICU ward care and drug treatment after admission,and the observation group and control group were additionally treated with the nasal CPAP combined with small dose of glucocorticoid and conventional nasal catheter oxygen intake,respectively.The changes of the blood gas index and inflammatory cytokine level in two groups between before and after treatment were compared.Results:After treatment,the levels of PaO2,SaO2 and pH significantly increased,and the level of PaCO2 significantly decreased in two groups compared before treatment(P<0.01).After treatment,the levels of PaO2 and SaO2 and pH in observation group were significantly higher than those in control group,and the PaCO2 level in observation group was significantly lower than that in control group(P<0.01).After treatment,the level of IL-10 significantly increased,and the levels of CRP,TNF-α and sICAM-1 significantly decreased in two groups compared before treatment(P<0.01).After treatment,the levels of IL-10,CRP,TNF-α and sICAM-1 in observation group were significantly higher than those in control group(P<0.01).Conclusions:The nasal CPAP combined with small dose of corticosteroid in the treatment of severe pneumonia can improve the hypoxia and restore the acid-base balance by regulating the related inflammatory cytokine level in the short-term,which is superior to the conventional treatment.
Objective:To observe the effects of the nasal continuous positive airway pressure(CPAP) combined with small dose of corticosteroid on the blood gas index and inflammatory cytokine level in children with severe pneumonia.Methods:Seventy-eight children with severe pneumonia were divided into the observation group and control group according to the different treatment(39 cases each group).Two groups were treated with the conventional PICU ward care and drug treatment after admission,and the observation group and control group were additionally treated with the nasal CPAP combined with small dose of glucocorticoid and conventional nasal catheter oxygen intake,respectively.The changes of the blood gas index and inflammatory cytokine level in two groups between before and after treatment were compared.Results:After treatment,the levels of PaO2,SaO2 and pH significantly increased,and the level of PaCO2 significantly decreased in two groups compared before treatment(P<0.01).After treatment,the levels of PaO2 and SaO2 and pH in observation group were significantly higher than those in control group,and the PaCO2 level in observation group was significantly lower than that in control group(P<0.01).After treatment,the level of IL-10 significantly increased,and the levels of CRP,TNF-α and sICAM-1 significantly decreased in two groups compared before treatment(P<0.01).After treatment,the levels of IL-10,CRP,TNF-α and sICAM-1 in observation group were significantly higher than those in control group(P<0.01).Conclusions:The nasal CPAP combined with small dose of corticosteroid in the treatment of severe pneumonia can improve the hypoxia and restore the acid-base balance by regulating the related inflammatory cytokine level in the short-term,which is superior to the conventional treatment.
2017, 42(12): 1621-1623.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.015
Abstract:
Objective:To explore the application effects of the harmonic scalpel in the reoperation of differentiated thyroid carcinoma.Methods:Fifty-two patients with differentiated thyroid carcinoma were treated with local section according to benign masses treatment method,and identified using pathological examination.The patients were randomly divided into the harmonic scalpel group(25 cases treated with harmonic scalpel) and conventional group(27 cases treated with traditional ligation method).All operations were performed by the same doctors.The total operation time,intraoperative bleeding,postoperative drainage and surgical complications(including postoperative bleeding,postoperative recurrent laryngeal nerve paralysis and postoperative hypoparathyroidism) between two groups were compared.The recurrence rate of residual cancer after half a year of operation was observed using the regular follow-up and reexamination,and the quality of life of patients after six months of surgery was assessed using the Karnofsky score.Results:The reoperation time,intraoperative bleeding and postoperative drainage in harmonic scalpel group were less than those in conventional group(P<0.01),and the quality of life in harmonic scalpel group after six months of surgery in harmonic scalpel group was significantly better than that in conventional group(P<0.01).The differences of the postoperative recurrent laryngeal nerve injury,incidence rates of transient and perpetual hypoparathyroidism,recurrence rate of residual cancer after half a year of operation and cost between two groups were not statistically significant(P>0.05).Conclusions:The effect of harmonic scalpel in the reoperation of differentiated thyroid carcinoma is better than that of traditional ligation method,which is worthy of promotion.
Objective:To explore the application effects of the harmonic scalpel in the reoperation of differentiated thyroid carcinoma.Methods:Fifty-two patients with differentiated thyroid carcinoma were treated with local section according to benign masses treatment method,and identified using pathological examination.The patients were randomly divided into the harmonic scalpel group(25 cases treated with harmonic scalpel) and conventional group(27 cases treated with traditional ligation method).All operations were performed by the same doctors.The total operation time,intraoperative bleeding,postoperative drainage and surgical complications(including postoperative bleeding,postoperative recurrent laryngeal nerve paralysis and postoperative hypoparathyroidism) between two groups were compared.The recurrence rate of residual cancer after half a year of operation was observed using the regular follow-up and reexamination,and the quality of life of patients after six months of surgery was assessed using the Karnofsky score.Results:The reoperation time,intraoperative bleeding and postoperative drainage in harmonic scalpel group were less than those in conventional group(P<0.01),and the quality of life in harmonic scalpel group after six months of surgery in harmonic scalpel group was significantly better than that in conventional group(P<0.01).The differences of the postoperative recurrent laryngeal nerve injury,incidence rates of transient and perpetual hypoparathyroidism,recurrence rate of residual cancer after half a year of operation and cost between two groups were not statistically significant(P>0.05).Conclusions:The effect of harmonic scalpel in the reoperation of differentiated thyroid carcinoma is better than that of traditional ligation method,which is worthy of promotion.
2017, 42(12): 1624-1626.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.016
Abstract:
Objective:To analyze the effects of the resection by areola arc incision in treating breast fibroma on breast injury and postoperative breastfeeding rate.Methods:Sixty patients with breast fibroma were randomly divided into the observation group and control group.The observation group was treated with the resection by areola arc incision,and the control group was treated with the conventional radial incision by nipple as the center of operation.The peroperative bleeding,operation time,time of postoperative stitches removal,scar size,hematoma size,satisfaction of postoperative breast appearance,fertility and breastfeeding of fertility patients between two groups were compared.Results:The operation time in observation group was significantly longer than that in control group(P<0.01),but the peroperative bleeding and time of postoperative stitches removal in observation group were significantly less than those in control group(P<0.01).The scar length in observation group was significantly less than that in control group(P<0.01),and the difference of the incidence rate of complication between two groups was not statistically significant(P>0.05).The satisfaction rate of postoperative breast appearance in observation group was significantly better than that in control group(P<0.01),and the difference of the breastfeeding rate of fertility patients between two groups was not statistically significant(P>0.05).Conclusions:The resection by areolar incision in the treatment of breast fibroma can effectively reduce the peroperative injury,and improve the postoperative breastfeeding rate of patients.
Objective:To analyze the effects of the resection by areola arc incision in treating breast fibroma on breast injury and postoperative breastfeeding rate.Methods:Sixty patients with breast fibroma were randomly divided into the observation group and control group.The observation group was treated with the resection by areola arc incision,and the control group was treated with the conventional radial incision by nipple as the center of operation.The peroperative bleeding,operation time,time of postoperative stitches removal,scar size,hematoma size,satisfaction of postoperative breast appearance,fertility and breastfeeding of fertility patients between two groups were compared.Results:The operation time in observation group was significantly longer than that in control group(P<0.01),but the peroperative bleeding and time of postoperative stitches removal in observation group were significantly less than those in control group(P<0.01).The scar length in observation group was significantly less than that in control group(P<0.01),and the difference of the incidence rate of complication between two groups was not statistically significant(P>0.05).The satisfaction rate of postoperative breast appearance in observation group was significantly better than that in control group(P<0.01),and the difference of the breastfeeding rate of fertility patients between two groups was not statistically significant(P>0.05).Conclusions:The resection by areolar incision in the treatment of breast fibroma can effectively reduce the peroperative injury,and improve the postoperative breastfeeding rate of patients.
2017, 42(12): 1627-1629,1633.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.017
Abstract:
Objective:To explore the diagnostic value of midregion of pro-atrial natriuretic peptide(MR-proANP) for heart failure in dyspnea patients.Methods:The serum levels of MR-proANP in 203 dyspnea patients[including 96 heart failure(HF) patients and 107 non-HF patients] on admission was determined by KRYPTOR platform.The diagnostic value of MR-proANP for HF was analyzed using receiver operating characteristic(ROC) curve,and which was compared with amino-terminal pro-B type natriuretic peptide(NT-proBNP).The MR-proANP and NT-proBNP were combined into an index using logistic regression model,which was used to analyze its diagnostic accuracy for HF.The relationships between cardiac function of New York Heart Association(NYHA),NT-proBNP and MR-proANP were analyzed.The reference range of MR-proANP was established by 120 healthy examinees.Results:The serum level of MR-proANP in HF patients was higher than that in non-HF patients(P<0.01).The difference of the area under ROC curve between NT-proBNP and MR-proANP was not statistically significant(P>0.05).The area under ROC curve of the joint diagnosis of heart failure with NT-proBNP and MR-proANP was higher than that in MR-proANP or NT-proBNP(P<0.05).The optimal threshold,sensitivity and specificity of MR-proANP were 100 pmol/L,0.91(0.83 to 0.96) ad 0.64(0.55 to 0.74),respectively.With the cardiac function classification of NYHA increasing,the level of MR-proANP increased(P<0.01),and the MR-proANP was positively correlated with NT-proBNP(rs=0.64,P<0.01).Conclusions:MR-proANP is a useful diagnostic marker for HF in dyspnea patients.The combined detection of MR-proANP and NT-proBNP can improve the diagnostic accuracy of HF.
Objective:To explore the diagnostic value of midregion of pro-atrial natriuretic peptide(MR-proANP) for heart failure in dyspnea patients.Methods:The serum levels of MR-proANP in 203 dyspnea patients[including 96 heart failure(HF) patients and 107 non-HF patients] on admission was determined by KRYPTOR platform.The diagnostic value of MR-proANP for HF was analyzed using receiver operating characteristic(ROC) curve,and which was compared with amino-terminal pro-B type natriuretic peptide(NT-proBNP).The MR-proANP and NT-proBNP were combined into an index using logistic regression model,which was used to analyze its diagnostic accuracy for HF.The relationships between cardiac function of New York Heart Association(NYHA),NT-proBNP and MR-proANP were analyzed.The reference range of MR-proANP was established by 120 healthy examinees.Results:The serum level of MR-proANP in HF patients was higher than that in non-HF patients(P<0.01).The difference of the area under ROC curve between NT-proBNP and MR-proANP was not statistically significant(P>0.05).The area under ROC curve of the joint diagnosis of heart failure with NT-proBNP and MR-proANP was higher than that in MR-proANP or NT-proBNP(P<0.05).The optimal threshold,sensitivity and specificity of MR-proANP were 100 pmol/L,0.91(0.83 to 0.96) ad 0.64(0.55 to 0.74),respectively.With the cardiac function classification of NYHA increasing,the level of MR-proANP increased(P<0.01),and the MR-proANP was positively correlated with NT-proBNP(rs=0.64,P<0.01).Conclusions:MR-proANP is a useful diagnostic marker for HF in dyspnea patients.The combined detection of MR-proANP and NT-proBNP can improve the diagnostic accuracy of HF.
2017, 42(12): 1630-1633.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.018
Abstract:
Objective:To explore the carotid plaque integral,analyze the correlation between carotid plaque vulnerability and biochemical indicator in patients with progressive stroke for increasing the clinical knowledge of comprehensive intervention in carotid plaque.Methods:The integral and vulnerability of carotid plaques in 102 patients with progressive stroke were evaluated,and the correlations between carotid plaque vulnerability and biochemical indicators(fasting plasma glucose,total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,lipoprotein a,homocysteine,C reactive protein and fibrinogen) were analyzed.Results:Three hundred and one plaques in 102 patients with progressive stroke were detected,which included 257 vulnerable plaques(85.4%,257/301),and the mean integral of carotid plaques was(11.24±4.56)mm.There were positive correlations between the mean integral of carotid plaques,and fasting plasma glucose,low density lipoprotein,lipoprotein a,homocysteine,C reactive protein and fibrinogen(P<0.01),and there was negative relation between the mean integral of carotid plaques and high density lipoprotein(P<0.05).The lipoprotein a,homocysteine and C reactive protein were the independent risk factors of vulnerable plaques(P<0.05).Conclusions:The carotid plaques nature is closely related to biochemical indicator in patients with progressive stroke,and the lipoprotein a,homocysteine and C reactive protein are the independent risk factors of vulnerable plaques.
Objective:To explore the carotid plaque integral,analyze the correlation between carotid plaque vulnerability and biochemical indicator in patients with progressive stroke for increasing the clinical knowledge of comprehensive intervention in carotid plaque.Methods:The integral and vulnerability of carotid plaques in 102 patients with progressive stroke were evaluated,and the correlations between carotid plaque vulnerability and biochemical indicators(fasting plasma glucose,total cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,lipoprotein a,homocysteine,C reactive protein and fibrinogen) were analyzed.Results:Three hundred and one plaques in 102 patients with progressive stroke were detected,which included 257 vulnerable plaques(85.4%,257/301),and the mean integral of carotid plaques was(11.24±4.56)mm.There were positive correlations between the mean integral of carotid plaques,and fasting plasma glucose,low density lipoprotein,lipoprotein a,homocysteine,C reactive protein and fibrinogen(P<0.01),and there was negative relation between the mean integral of carotid plaques and high density lipoprotein(P<0.05).The lipoprotein a,homocysteine and C reactive protein were the independent risk factors of vulnerable plaques(P<0.05).Conclusions:The carotid plaques nature is closely related to biochemical indicator in patients with progressive stroke,and the lipoprotein a,homocysteine and C reactive protein are the independent risk factors of vulnerable plaques.
2017, 42(12): 1634-1637,1640.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.019
Abstract:
Objective:To explore the effects of different doses of oxycodone combined with etomidate in the application of painless artificial abortion.Methods:One hundred and twenty early pregnancy patients scheduled by painless artificial abortion were randomly divided into the fentanyl group,low,medium and high dose of oxycodone groups(30 cases each group).The fentanyl group,low,medium and high dose of oxycodone groups were treated with 1.0 μg/kg fentanyl,and 0.05,0.1 and 0.15 mg/kg oxycodone by intravenous injection,respectively.All cases were treated with 0.3 mg/kg etomidate by intravenous injection after 5 min,and operated after the disappearance of eyelash reflex.The efficacy and safety between four groups were compared.Results:The differences of the time of eyelash reflex disappearing,open the eyes after calling and wide-awake between four groups were not statistically significant(P>0.05).The number of the cases treated with additional etomidate in fentanyl group,medium and high dose of oxycodone groups were significantly less than that in low dose of oxycodone group(P<0.01).During etomidate treatment to wide-awake,the differences of blood pressure,heart rate,respiration rate and pulse oxygen saturation between four groups were not statistically significant(P>0.05).The scores of uterine contraction pain in medium and high dose of oxycodone groups at wide-awake and after 30 min and 2 h of awake were significantly lower than that in low dose of oxycodone group(P<0.01),and the scores of uterine contraction pain in high dose of oxycodone group at wide-awake,and in medium and high dose of oxycodone groups after 30 min and 2 h of awake were significantly lower than that in fentanyl group(P<0.05 to P<0.01).The differences of the number of the cases with dizziness,respiratory depression,nausea and vomiting between four groups were not statistically significant(P>0.05),and the number of the cases with myoclonus in medium and high dose of oxycodone groups were significantly less than that in fentanyl group and low dose of oxycodone group(P<0.05 to P<0.01).Conclusions:The effect of 0.1 mg/kg oxycodone combined with etomidate in the application of painless artificial abortion is better,which can reduce the uterine contraction pain and myoclonus.
Objective:To explore the effects of different doses of oxycodone combined with etomidate in the application of painless artificial abortion.Methods:One hundred and twenty early pregnancy patients scheduled by painless artificial abortion were randomly divided into the fentanyl group,low,medium and high dose of oxycodone groups(30 cases each group).The fentanyl group,low,medium and high dose of oxycodone groups were treated with 1.0 μg/kg fentanyl,and 0.05,0.1 and 0.15 mg/kg oxycodone by intravenous injection,respectively.All cases were treated with 0.3 mg/kg etomidate by intravenous injection after 5 min,and operated after the disappearance of eyelash reflex.The efficacy and safety between four groups were compared.Results:The differences of the time of eyelash reflex disappearing,open the eyes after calling and wide-awake between four groups were not statistically significant(P>0.05).The number of the cases treated with additional etomidate in fentanyl group,medium and high dose of oxycodone groups were significantly less than that in low dose of oxycodone group(P<0.01).During etomidate treatment to wide-awake,the differences of blood pressure,heart rate,respiration rate and pulse oxygen saturation between four groups were not statistically significant(P>0.05).The scores of uterine contraction pain in medium and high dose of oxycodone groups at wide-awake and after 30 min and 2 h of awake were significantly lower than that in low dose of oxycodone group(P<0.01),and the scores of uterine contraction pain in high dose of oxycodone group at wide-awake,and in medium and high dose of oxycodone groups after 30 min and 2 h of awake were significantly lower than that in fentanyl group(P<0.05 to P<0.01).The differences of the number of the cases with dizziness,respiratory depression,nausea and vomiting between four groups were not statistically significant(P>0.05),and the number of the cases with myoclonus in medium and high dose of oxycodone groups were significantly less than that in fentanyl group and low dose of oxycodone group(P<0.05 to P<0.01).Conclusions:The effect of 0.1 mg/kg oxycodone combined with etomidate in the application of painless artificial abortion is better,which can reduce the uterine contraction pain and myoclonus.
2017, 42(12): 1638-1640.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.020
Abstract:
Objective:To compare the effects of postoperative analgesia between continuous lumbar plexus block and femoral nerve block in total knee replacement.Methods:Seventy-four patients treated with total knee replacement surgery from December 2014 to September were randomly divided into the continuous femoral nerve block group and continuous lumbar plexus block group(37 cases each group).The scores of VAS of resting after 4 h,8 h,16 h and 32 h of operation,and acting after 16 h and 32h of operation in two groups were recorded.The scores of knee joint function in two groups before operation and after 2 weeks and 10 weeks of operation were evaluated.The incidence rates of adverse reaction in two groups were recorded.Results:The scores of VAS of resting after 4 h,8 h,16 h and 32 h of operation,and acting after 16 h and 32 h of operation in continuous lumbar plexus block group were significantly lower than those in continuous femoral nerve block group(P<0.05 to P<0.01).Compared before operation,the HSS scores of preoperative 2 weeks and 12 weeks in two groups significantly increased(P<0.01).The incidence rate of adverse reaction in continuous femoral nerve block group(37.84%) was significantly higher than that in continuous lumbar plexus block group(16.22%)(P<0.05).Conclusions:The effect of continuous lumbar plexus block group on postoperative analgesia in knee replacement is better than that of the continuous femoral nerve block,the adverse reaction of which is light,which has important clinical significance.
Objective:To compare the effects of postoperative analgesia between continuous lumbar plexus block and femoral nerve block in total knee replacement.Methods:Seventy-four patients treated with total knee replacement surgery from December 2014 to September were randomly divided into the continuous femoral nerve block group and continuous lumbar plexus block group(37 cases each group).The scores of VAS of resting after 4 h,8 h,16 h and 32 h of operation,and acting after 16 h and 32h of operation in two groups were recorded.The scores of knee joint function in two groups before operation and after 2 weeks and 10 weeks of operation were evaluated.The incidence rates of adverse reaction in two groups were recorded.Results:The scores of VAS of resting after 4 h,8 h,16 h and 32 h of operation,and acting after 16 h and 32 h of operation in continuous lumbar plexus block group were significantly lower than those in continuous femoral nerve block group(P<0.05 to P<0.01).Compared before operation,the HSS scores of preoperative 2 weeks and 12 weeks in two groups significantly increased(P<0.01).The incidence rate of adverse reaction in continuous femoral nerve block group(37.84%) was significantly higher than that in continuous lumbar plexus block group(16.22%)(P<0.05).Conclusions:The effect of continuous lumbar plexus block group on postoperative analgesia in knee replacement is better than that of the continuous femoral nerve block,the adverse reaction of which is light,which has important clinical significance.
2017, 42(12): 1641-1644.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.021
Abstract:
Objective:To investigate the effects of the Mirena combined with yasmin in the treatment of perimenopausal dysfunctional uterine bleeding.Methods:One hundred and seventy-eight patients with perimenopausal dysfunctional uterine bleeding were divided into the joint group and control group according to the random number table(78 cases each group).After 5 d of diagnostic curettage,the control group was treated with 12.5 mg of mifepristone,and the joint group was additionally treated with 30 μg of yasmin combined with mirena by oral based on control group.The serum levels of follicle hormone assay,luteinizing hormone(LH) and estradiol(E2) in two groups were detected using enzyme-linked immunosorbent assay.Two groups were followed up for 6 months.The amount of bleeding and menstruation,and serum levels of FSH,LH and E2 in two groups before and after treatment were recorded.The endometrial thickness and incidence rate of adverse reactions in two groups before and after 2,4 and 6 months of treatment were observed.Results:After treatment,the haemorrhage stopping time in joint group[(13.07±2.71)d] was significantly lower than that in control group[(15.78±3.24)d](P<0.01),and the treatment efficiency in joint group was higher than that in control group(P<0.05).After treatment,and the serum levels of FSH,LH and E2 in joint group were higher than those in control group(P<0.01).After 2,4 and 6 months of treatment,the endometrial thickness in joint group were significantly lower than that in control group(P<0.01).The difference of the incidence rate of adverse reactions between two groups was not statistically significant(P>0.05).Conclusions:The treatment of Mirena combined with yasmin can effectively improve the perimenopausal dysfunctional uterine bleeding and uterine endocrine environment,reduce the endometrial thickness,and do not increase the incidence of adverse reaction,which is worthy of further promotion.
Objective:To investigate the effects of the Mirena combined with yasmin in the treatment of perimenopausal dysfunctional uterine bleeding.Methods:One hundred and seventy-eight patients with perimenopausal dysfunctional uterine bleeding were divided into the joint group and control group according to the random number table(78 cases each group).After 5 d of diagnostic curettage,the control group was treated with 12.5 mg of mifepristone,and the joint group was additionally treated with 30 μg of yasmin combined with mirena by oral based on control group.The serum levels of follicle hormone assay,luteinizing hormone(LH) and estradiol(E2) in two groups were detected using enzyme-linked immunosorbent assay.Two groups were followed up for 6 months.The amount of bleeding and menstruation,and serum levels of FSH,LH and E2 in two groups before and after treatment were recorded.The endometrial thickness and incidence rate of adverse reactions in two groups before and after 2,4 and 6 months of treatment were observed.Results:After treatment,the haemorrhage stopping time in joint group[(13.07±2.71)d] was significantly lower than that in control group[(15.78±3.24)d](P<0.01),and the treatment efficiency in joint group was higher than that in control group(P<0.05).After treatment,and the serum levels of FSH,LH and E2 in joint group were higher than those in control group(P<0.01).After 2,4 and 6 months of treatment,the endometrial thickness in joint group were significantly lower than that in control group(P<0.01).The difference of the incidence rate of adverse reactions between two groups was not statistically significant(P>0.05).Conclusions:The treatment of Mirena combined with yasmin can effectively improve the perimenopausal dysfunctional uterine bleeding and uterine endocrine environment,reduce the endometrial thickness,and do not increase the incidence of adverse reaction,which is worthy of further promotion.
2017, 42(12): 1645-1647.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.022
Abstract:
Objective:To investigate the correlations between neonatal multiple organ damage(MOD),and birth weight(BW),gestational age(GA),1-and 5-minute Apgar scores.Methods:Two hundred and sixty-nine newborns with MOD were divided into the <1 500 g,1 500 g to <2 500 g,and 2 500 to 4 000 g groups according to BW,<32 weeks,32 to <37 weeks,and 37 to 42 weeks groups according to GA,and ≤ 7 and 8 to 10 scores of 1-minute and 5-minute groups according to the Apgar score.The incidence of MOD in each group was calculated.The incidence rates of the number of organ damage(2,3,or more than 3) in different BW and GA groups were compared.Results:With the increasing of BW and GA,the incidence rate of MOD decreased(P<0.01).With the decreasing of BW and GA,the incidence rate of number of organ damage(3,or more than 3) increased(P<0.01).The incidence rate of MOD in 1-minute and 5-minute Apgar scores ≤ 7 patients was more than that in 1-minute and 5-minute Apgar scores for 8 to 10 patients(P<0.01).Conclusions:Low BW,premature babies and low Apgar score,especially the low 5-minute Apgar score,are the risk fators of neonatal MOD.The incidence rate of MOD and number of organ damage are negatively correlated with BW and GA.
Objective:To investigate the correlations between neonatal multiple organ damage(MOD),and birth weight(BW),gestational age(GA),1-and 5-minute Apgar scores.Methods:Two hundred and sixty-nine newborns with MOD were divided into the <1 500 g,1 500 g to <2 500 g,and 2 500 to 4 000 g groups according to BW,<32 weeks,32 to <37 weeks,and 37 to 42 weeks groups according to GA,and ≤ 7 and 8 to 10 scores of 1-minute and 5-minute groups according to the Apgar score.The incidence of MOD in each group was calculated.The incidence rates of the number of organ damage(2,3,or more than 3) in different BW and GA groups were compared.Results:With the increasing of BW and GA,the incidence rate of MOD decreased(P<0.01).With the decreasing of BW and GA,the incidence rate of number of organ damage(3,or more than 3) increased(P<0.01).The incidence rate of MOD in 1-minute and 5-minute Apgar scores ≤ 7 patients was more than that in 1-minute and 5-minute Apgar scores for 8 to 10 patients(P<0.01).Conclusions:Low BW,premature babies and low Apgar score,especially the low 5-minute Apgar score,are the risk fators of neonatal MOD.The incidence rate of MOD and number of organ damage are negatively correlated with BW and GA.
2017, 42(12): 1661-1663.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.029
Abstract:
Objective:To investigate the job satisfaction and its influencing factors in information personnel in tertiary hospital of Anhui.Methods:The job satisfactions of 258 information personnels from 25 tertiary hospitals in Anhui were investigated using the JSS scale,and the influencing factor of which was analyzed using multinomial linear regression.Results:The average score of job satisfaction of information personnel was (140.19±23.18).Among the nine dimensions,the scores of leader satisfaction(19.35±3.67),colleague satisfaction(17.44±2.99) and communication satisfaction(16.84±3.66) were higher,and the scores of salary satisfaction(13.19±3.80),workflow satisfaction(13.58±2.74) and promotion satisfaction(14.32±3.75) were lower.The differences of the job satisfaction scores in different ages,professional degree,professional title,year of work and training time in the past 3 years in information personnel were statistically significant(P<0.05 to P<0.01).The results of multinomial regression analysis showed that the job satisfaction was positively associated with professional title and training time in the past 3 years(P<0.05 and P<0.01),and negatively associated with year of work(P<0.05).Conclusions:The salary,workflow and promotion are the main choke point of job satisfaction,and the professional title,training time and work experience are the main influencing factors of the job satisfaction in information personnel in tertiary hospitals.
Objective:To investigate the job satisfaction and its influencing factors in information personnel in tertiary hospital of Anhui.Methods:The job satisfactions of 258 information personnels from 25 tertiary hospitals in Anhui were investigated using the JSS scale,and the influencing factor of which was analyzed using multinomial linear regression.Results:The average score of job satisfaction of information personnel was (140.19±23.18).Among the nine dimensions,the scores of leader satisfaction(19.35±3.67),colleague satisfaction(17.44±2.99) and communication satisfaction(16.84±3.66) were higher,and the scores of salary satisfaction(13.19±3.80),workflow satisfaction(13.58±2.74) and promotion satisfaction(14.32±3.75) were lower.The differences of the job satisfaction scores in different ages,professional degree,professional title,year of work and training time in the past 3 years in information personnel were statistically significant(P<0.05 to P<0.01).The results of multinomial regression analysis showed that the job satisfaction was positively associated with professional title and training time in the past 3 years(P<0.05 and P<0.01),and negatively associated with year of work(P<0.05).Conclusions:The salary,workflow and promotion are the main choke point of job satisfaction,and the professional title,training time and work experience are the main influencing factors of the job satisfaction in information personnel in tertiary hospitals.
2017, 42(12): 1664-1667.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.030
Abstract:
Objective:To investigate the current situation of regional food and local tea intake by residents in Huangshan area,discuss the relationship between the regional food intake and overweight/obesity rate,and provide basis for improving the healthy condition of residents.Methods:Using a convenient sampling method,five hundred and eighteen households from three districts and four counties of Huangshan area were selected,and a member who was over 40 years old from each family was selected as the research object.The food frequency questionnaire was used to record the intake frequency and amount of regional food for a year,which were converted into a standard adult daily intake.Results:The rate of overweight/obesity was 26.6%(38/518),and the rate of abdominal obesity was 28.76%(149/518).The difference of overweight/obesity rate in different age residents was statistically significant (P<0.05).While the difference of overweight/obesity rate in residents of different sex,education,smoking,drink and labor situation was not statistically significant(P>0.05),and the difference of abdominal obesity rate in residents of different sex,age,education,smoking,drink,sport and labor situation was also not statistically significant(P>0.05).The difference of overweight/obesity rate in residents with different intake frequency of Huangshan pancake and tea was statistically significant (P<0.05),while other regional foods did not obviously affect the overweight/obesity rate of residents(P>0.05).The result of logistic regression analysis indicated that the increasing frequency of Huangshan pancake intake was the risk factor of overweight/obesity(OR=1.432,P<0.05).Conclusions:The intake frequency of Huangshan pancake and tea maybe has some influences on the local residents' overweight/obesity.
Objective:To investigate the current situation of regional food and local tea intake by residents in Huangshan area,discuss the relationship between the regional food intake and overweight/obesity rate,and provide basis for improving the healthy condition of residents.Methods:Using a convenient sampling method,five hundred and eighteen households from three districts and four counties of Huangshan area were selected,and a member who was over 40 years old from each family was selected as the research object.The food frequency questionnaire was used to record the intake frequency and amount of regional food for a year,which were converted into a standard adult daily intake.Results:The rate of overweight/obesity was 26.6%(38/518),and the rate of abdominal obesity was 28.76%(149/518).The difference of overweight/obesity rate in different age residents was statistically significant (P<0.05).While the difference of overweight/obesity rate in residents of different sex,education,smoking,drink and labor situation was not statistically significant(P>0.05),and the difference of abdominal obesity rate in residents of different sex,age,education,smoking,drink,sport and labor situation was also not statistically significant(P>0.05).The difference of overweight/obesity rate in residents with different intake frequency of Huangshan pancake and tea was statistically significant (P<0.05),while other regional foods did not obviously affect the overweight/obesity rate of residents(P>0.05).The result of logistic regression analysis indicated that the increasing frequency of Huangshan pancake intake was the risk factor of overweight/obesity(OR=1.432,P<0.05).Conclusions:The intake frequency of Huangshan pancake and tea maybe has some influences on the local residents' overweight/obesity.
2017, 42(12): 1668-1669,1673.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.031
Abstract:
Objective:To investigate the bone mineral density(BMD) of young men in Shanghai Beicai area.Methods:The levels of BMD of lumber vertebra and left proximal femur in 223 healthy men,20 to 40 years old,in Shanghai Beicai area were examined using dual energy X-ray bone density instrument,and the cases were investigated by questionnaire survey.Results:The differences of the effects of weight and body mass index(BMI) on BMD were statistically significant(P<0.05).The differences of the effects of age,educational level,diet,sport,sleep,drinking,smoking,fish,shrimp,milk,yogurt,coffee,fracture history and surgery history on BMD were not statistically significant(P>0.05).Conclusions:The body weight and BMI have effect on the level of BMD in young men.
Objective:To investigate the bone mineral density(BMD) of young men in Shanghai Beicai area.Methods:The levels of BMD of lumber vertebra and left proximal femur in 223 healthy men,20 to 40 years old,in Shanghai Beicai area were examined using dual energy X-ray bone density instrument,and the cases were investigated by questionnaire survey.Results:The differences of the effects of weight and body mass index(BMI) on BMD were statistically significant(P<0.05).The differences of the effects of age,educational level,diet,sport,sleep,drinking,smoking,fish,shrimp,milk,yogurt,coffee,fracture history and surgery history on BMD were not statistically significant(P>0.05).Conclusions:The body weight and BMI have effect on the level of BMD in young men.
2017, 42(12): 1670-1673.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.032
Abstract:
Objective:To explore the breast ultrasonographic and pathologic characteristics of breast phyllodes tumor(PTB),and the breast sentinel lymph node involvement of different types phyllodes tumor.Methods:The data of breast ultrasonography findings and sentinel lymph node biopsy in 45 cases with PTB diagnosed by pathology were retrospectively analyzed,which was compared with pathological results.Results:Among 45 cases(49 PTBs),benign tumor in 31 cases,borderline tumor in 12 cases and malignant tumor in 6 cases were identified.All mass were substantial low echo or mixed echo,the lobulated form and clear boundary was more common(P<0.05),and the internal echo was uneven.Color Doppler showed that the level Ⅱ-Ⅲ blood flow signal was found in 59.2%(29/49) mass.The clear boundary in benign lobulated tumor was more common(P<0.05),and the sentinel lymph node of which was not involved.The polycystic change in malignant tumor inner was found(P<0.01),and the sentinel lymph node of which was involved(P<0.01).Conclusions:The sonographic findings of PTB has certain characteristics,and the clear boundary of mass,cystic change of tumor inner complicated with axillary lymph node involvement are important basis in identifying benign and malignant tumor.
Objective:To explore the breast ultrasonographic and pathologic characteristics of breast phyllodes tumor(PTB),and the breast sentinel lymph node involvement of different types phyllodes tumor.Methods:The data of breast ultrasonography findings and sentinel lymph node biopsy in 45 cases with PTB diagnosed by pathology were retrospectively analyzed,which was compared with pathological results.Results:Among 45 cases(49 PTBs),benign tumor in 31 cases,borderline tumor in 12 cases and malignant tumor in 6 cases were identified.All mass were substantial low echo or mixed echo,the lobulated form and clear boundary was more common(P<0.05),and the internal echo was uneven.Color Doppler showed that the level Ⅱ-Ⅲ blood flow signal was found in 59.2%(29/49) mass.The clear boundary in benign lobulated tumor was more common(P<0.05),and the sentinel lymph node of which was not involved.The polycystic change in malignant tumor inner was found(P<0.01),and the sentinel lymph node of which was involved(P<0.01).Conclusions:The sonographic findings of PTB has certain characteristics,and the clear boundary of mass,cystic change of tumor inner complicated with axillary lymph node involvement are important basis in identifying benign and malignant tumor.
2017, 42(12): 1674-1676.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.033
Abstract:
Objective:To explore the clinical application value of real-time contrast-enhanced ultrasonography in thyroid nodule treated with radiofrequency ablation(RFA).Methods:Seventy-five thyroid nodules(TN) patients(88 nodules) were randomly divided the group A(40 cases,48 nodules) and group B(35 cases,40 nodules).Group A was examined using real-time contrast-enhanced ultrasonography before and after treatment,and the nodules of incomplete deactivation were treated with RFA in time.Group B was set as control group.The treatment security,clinical symptoms and thyroid function in two groups were observed after treatment.The long-term therapeutic effects between two groups were compared.Results:After treatment with RFA,21 incomplete deactivation nodules in group A were treated in time.No serious complication in 2 groups was identified.The thyroid function indexes in two groups were in normal range after treatment.The difference of complete necrosis rate of nodules between two groups was statistically significant(P<0.01).After 6 and 12 months of treatment,the nodule volume reduction rates in group A and group B were 83.7%,96.2% and 56.5%,68.3%,respectively.At the same time,the nodule volume reduction rate in group A was significantly higher than that in group B(P<0.01).Conclusions:The real-time contrast-enhanced ultrasonography in thyroid nodule treated with RFA can guide the positioning and supplementary ablation therapy,effectively improve the complete inactivation rate and long-term efficacy,which has better clinical values.
Objective:To explore the clinical application value of real-time contrast-enhanced ultrasonography in thyroid nodule treated with radiofrequency ablation(RFA).Methods:Seventy-five thyroid nodules(TN) patients(88 nodules) were randomly divided the group A(40 cases,48 nodules) and group B(35 cases,40 nodules).Group A was examined using real-time contrast-enhanced ultrasonography before and after treatment,and the nodules of incomplete deactivation were treated with RFA in time.Group B was set as control group.The treatment security,clinical symptoms and thyroid function in two groups were observed after treatment.The long-term therapeutic effects between two groups were compared.Results:After treatment with RFA,21 incomplete deactivation nodules in group A were treated in time.No serious complication in 2 groups was identified.The thyroid function indexes in two groups were in normal range after treatment.The difference of complete necrosis rate of nodules between two groups was statistically significant(P<0.01).After 6 and 12 months of treatment,the nodule volume reduction rates in group A and group B were 83.7%,96.2% and 56.5%,68.3%,respectively.At the same time,the nodule volume reduction rate in group A was significantly higher than that in group B(P<0.01).Conclusions:The real-time contrast-enhanced ultrasonography in thyroid nodule treated with RFA can guide the positioning and supplementary ablation therapy,effectively improve the complete inactivation rate and long-term efficacy,which has better clinical values.
2017, 42(12): 1677-1680.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.034
Abstract:
Objective:To explore the effects of group peer-counseling on depression in forced drug abstainers.Methods:One hundred and forty forced drug abstainers were randomly divided into the observation group and control group(70 cases each group).The observation group was intervened with group peer-counseling for 6 months,and the control group was not intervened with the scheme.The depression in two groups before and after intervention was evaluated using Self-Rating Depression Scale(SDS).Results:Before intervention,the difference of the score of depression between two groups was not statistically significant(P>0.05).After intervention,the score of depression of male without depression in observation group was significantly lower than that of male in control group(P<0.01),the score of depression of female with light depression in observation group was significantly higher than that of female in control group(P<0.01),and the score of depression of female with moderate-severe depression in observation group was significantly lower than that of female in control group(P<0.01).Conclusions:Group peer-counseling can relieve the depression of forced drug abstainers,but which needs to be further validated and improved in future research.
Objective:To explore the effects of group peer-counseling on depression in forced drug abstainers.Methods:One hundred and forty forced drug abstainers were randomly divided into the observation group and control group(70 cases each group).The observation group was intervened with group peer-counseling for 6 months,and the control group was not intervened with the scheme.The depression in two groups before and after intervention was evaluated using Self-Rating Depression Scale(SDS).Results:Before intervention,the difference of the score of depression between two groups was not statistically significant(P>0.05).After intervention,the score of depression of male without depression in observation group was significantly lower than that of male in control group(P<0.01),the score of depression of female with light depression in observation group was significantly higher than that of female in control group(P<0.01),and the score of depression of female with moderate-severe depression in observation group was significantly lower than that of female in control group(P<0.01).Conclusions:Group peer-counseling can relieve the depression of forced drug abstainers,but which needs to be further validated and improved in future research.
2017, 42(12): 1683-1686.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.036
Abstract:
Objective:To explore the effects of the health education based on protection motivation theory on the compliance of rehabilitation exercise in lung cancer patients after discharge.Methods:One hundred and twenty-four lung cancer patients were divided into the observation group(n=62) and control group(n=62).The control group was nursed with routine care,and the observation group was nursed with protect intervention model from discharge to after 6 months of discharge.The compliance of rehabilitation exercise,disease awareness,lung function and quality of life between two groups after discharge were compared.Results:The compliance of rehabilitation exercise and disease awareness rate in observation group were higher than those in control group(P<0.05).After intervention,the expiratory volume in the first second and peak expiratory flow rate in observation group were significantly higher than those in control group(P<0.01),and the scores of the overall health,psychological function,physical function,social function,mental health and emotional function were significantly higher than those in control group(P<0.01).Conclusions:The health education based on protection motivation theory can improve the disease awareness,compliance of rehabilitation exercise,lung function and quality of life in lung cancer patient after discharge.
Objective:To explore the effects of the health education based on protection motivation theory on the compliance of rehabilitation exercise in lung cancer patients after discharge.Methods:One hundred and twenty-four lung cancer patients were divided into the observation group(n=62) and control group(n=62).The control group was nursed with routine care,and the observation group was nursed with protect intervention model from discharge to after 6 months of discharge.The compliance of rehabilitation exercise,disease awareness,lung function and quality of life between two groups after discharge were compared.Results:The compliance of rehabilitation exercise and disease awareness rate in observation group were higher than those in control group(P<0.05).After intervention,the expiratory volume in the first second and peak expiratory flow rate in observation group were significantly higher than those in control group(P<0.01),and the scores of the overall health,psychological function,physical function,social function,mental health and emotional function were significantly higher than those in control group(P<0.01).Conclusions:The health education based on protection motivation theory can improve the disease awareness,compliance of rehabilitation exercise,lung function and quality of life in lung cancer patient after discharge.
2017, 42(12): 1686-1688.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.037
Abstract:
Objective:To explore the effects of Jidesheng Sheyao tablet topical concentration on the swelling caused by snakebite,and nursing experience.Methods:Ninety patients with snakebite were randomly divided into the low dose group,medium dose group and high dose group.Three groups were treated with appropriate antivenom,preventing tetanus,anti-infection,anti-fibrinolysis and improving microcirculation.Three groups were additionally treated with low dose,medium dose and high dose of Jidesheng Sheyao tablets,and good nursing,respectively.The clinical efficacy,main symptoms disappearing time and hospitalization time between three groups were compared.Results:After treatment,the total effective rate in low,medium and high dose groups were 63.3%,80.0% and 96.7%,respectively(P<0.05).The local swelling disappearing time,pain disappearing time,wound healing time and hospitalization time in high,medium and low dose groups gradually prolonged in turn(P<0.05 to P<0.01).Conclusions:On the basis of routine treatment and nursing,the different concentrations of Jidesheng Sheyao tablets can effectively alleviate the external swelling of snakebite,and the better clinical efficacy,the higher dose of tablet we will porate patients.
Objective:To explore the effects of Jidesheng Sheyao tablet topical concentration on the swelling caused by snakebite,and nursing experience.Methods:Ninety patients with snakebite were randomly divided into the low dose group,medium dose group and high dose group.Three groups were treated with appropriate antivenom,preventing tetanus,anti-infection,anti-fibrinolysis and improving microcirculation.Three groups were additionally treated with low dose,medium dose and high dose of Jidesheng Sheyao tablets,and good nursing,respectively.The clinical efficacy,main symptoms disappearing time and hospitalization time between three groups were compared.Results:After treatment,the total effective rate in low,medium and high dose groups were 63.3%,80.0% and 96.7%,respectively(P<0.05).The local swelling disappearing time,pain disappearing time,wound healing time and hospitalization time in high,medium and low dose groups gradually prolonged in turn(P<0.05 to P<0.01).Conclusions:On the basis of routine treatment and nursing,the different concentrations of Jidesheng Sheyao tablets can effectively alleviate the external swelling of snakebite,and the better clinical efficacy,the higher dose of tablet we will porate patients.
2017, 42(12): 1689-1691,1695.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.038
Abstract:
Objective:To improve the nursing link quality inspection method,and summarize its effects.Methods:The problem was surveyed according to baseline,and the nursing link quality inspection method was improved in view of the problem.The reforming effects in head nurse,nurse group leader,first-line nurse and discharge patient were investigated using self-made "the questionnaire of nursing link quality inspection method recognition" and "the satisfaction of discharged patients questionnaire".Results:The differences of the recognition degrees of "reflecting the overall nursing concept,implementing special guideline and understanding of quality inspection" in all nurses between before and after improving link quality inspection method were statistically significant(P<0.05).The recognition degrees of four items in various levels of nursing staff was consistent with the overall project.The results of pairwise comparison of four items recognition degrees were various.After improving the inspection method,the satisfaction of discharged patients significantly increased(P<0.01).Conclusions:Improving nursing link quality inspection method can improve the quality of nursing and satisfaction of discharged patients,which is worthy of popularization.
Objective:To improve the nursing link quality inspection method,and summarize its effects.Methods:The problem was surveyed according to baseline,and the nursing link quality inspection method was improved in view of the problem.The reforming effects in head nurse,nurse group leader,first-line nurse and discharge patient were investigated using self-made "the questionnaire of nursing link quality inspection method recognition" and "the satisfaction of discharged patients questionnaire".Results:The differences of the recognition degrees of "reflecting the overall nursing concept,implementing special guideline and understanding of quality inspection" in all nurses between before and after improving link quality inspection method were statistically significant(P<0.05).The recognition degrees of four items in various levels of nursing staff was consistent with the overall project.The results of pairwise comparison of four items recognition degrees were various.After improving the inspection method,the satisfaction of discharged patients significantly increased(P<0.01).Conclusions:Improving nursing link quality inspection method can improve the quality of nursing and satisfaction of discharged patients,which is worthy of popularization.
2017, 42(12): 1692-1695.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.039
Abstract:
Objective:To explore the effects of levocarnitine on the microinflammation state and nutritional status in patients with maintenance hemodialysis(MHD).Methods:A total of 88 end-stage renal disease(ESRD) patients treated with MHD were randomly divided into the observation group and control group.Two groups were treated with pure hemodialysis,folic acid,ferralia,EPO,and calcitriol.After hemodialysis,the observation group was injected with levocarnitine(1.0 g) and normal saline(20 mL) from the dialysis channel venous end,and the control group were only injected with normal saline(20 mL).Before treatment,and after 3 and 6 months of treatment,the level of hs-CRP,and levels of TNF-α,IL-6,and IL-8 in two groups were detected using transmission turbidimetry and ELISA,respectively,and the levels of Hb,PA,ALB,TC,TG,BUN,Cr,and β2-MG.in two groups were detected using full automatic biochemical analyzer.Results:The levels of hs-CRP,TNF-α,IL-6,and IL-8 at 3 and 6 months after treatment in the observation group were significantly reduced when compared with before treatment(P<0.01).IL-6,IL-8,and TNF-α levels at 3 and 6 months after treatment in the observation group were significantly lower than those in the control group(P<0.01).Hb,ALB,and PA levels at 3 and 6 months after treatment in the observation group were significantly elevated when compared with before treatment(P<0.05 to P<0.01).PA level at 3 months after treatment in the observation group was significantly higher than that in the control group(P<0.01).The comparison of Hb, PA, and ALB levels at 6 months after treatment between the two groups was significantly different(P<0.01).After 3 and 6 months of treatment,the level of β2-MG level in the observation group was significantly reduced when compared with before treatment(P<0.05 and P<0.01).After 6 months of treatment,the comparison of β2-MG level between the two groups was significantly different(P<0.01).Conclusions:Levocarnitine can effectively alleviate the microinflammation state,and improve the malnutrition status in patients with MHD.
Objective:To explore the effects of levocarnitine on the microinflammation state and nutritional status in patients with maintenance hemodialysis(MHD).Methods:A total of 88 end-stage renal disease(ESRD) patients treated with MHD were randomly divided into the observation group and control group.Two groups were treated with pure hemodialysis,folic acid,ferralia,EPO,and calcitriol.After hemodialysis,the observation group was injected with levocarnitine(1.0 g) and normal saline(20 mL) from the dialysis channel venous end,and the control group were only injected with normal saline(20 mL).Before treatment,and after 3 and 6 months of treatment,the level of hs-CRP,and levels of TNF-α,IL-6,and IL-8 in two groups were detected using transmission turbidimetry and ELISA,respectively,and the levels of Hb,PA,ALB,TC,TG,BUN,Cr,and β2-MG.in two groups were detected using full automatic biochemical analyzer.Results:The levels of hs-CRP,TNF-α,IL-6,and IL-8 at 3 and 6 months after treatment in the observation group were significantly reduced when compared with before treatment(P<0.01).IL-6,IL-8,and TNF-α levels at 3 and 6 months after treatment in the observation group were significantly lower than those in the control group(P<0.01).Hb,ALB,and PA levels at 3 and 6 months after treatment in the observation group were significantly elevated when compared with before treatment(P<0.05 to P<0.01).PA level at 3 months after treatment in the observation group was significantly higher than that in the control group(P<0.01).The comparison of Hb, PA, and ALB levels at 6 months after treatment between the two groups was significantly different(P<0.01).After 3 and 6 months of treatment,the level of β2-MG level in the observation group was significantly reduced when compared with before treatment(P<0.05 and P<0.01).After 6 months of treatment,the comparison of β2-MG level between the two groups was significantly different(P<0.01).Conclusions:Levocarnitine can effectively alleviate the microinflammation state,and improve the malnutrition status in patients with MHD.
2017, 42(12): 1696-1700.
doi: 10.13898/j.cnki.issn.1000-2200.2017.12.040
Abstract:
Objective:To investigate the effects of self-management intervention based on self-efficacy theory in patient with chronic obstructive pulmonary disease(COPD),and provide the evidence in optimizing medical service.Methods:One hundred and twenty-eight patients with stabilization period COPD were randomly divided into the observation group and control group(64 cases each group).The control group were nursed with routine method,and the observation group was nursed with self-management intervention based on self-efficacy theory.The heart and lung function in two groups were evaluated using the 6 min walk distance(6MWD) and medical research council scale(MRC),and the health knowledge,self-efficacy and quality of life improvement in two groups were evaluated using health knowledge questionnaire,self-efficacy scale and St.George's respiratory questionnaire(SGRQ) before and after 8 weeks of intervention.Results:Before intervention,the differences of the scores of 6MWD,MRC,health knowledge questionnaire,self-efficacy scale and SGRQ between two groups were not statistically significant(P>0.05).After intervention,the scores of 6MWD,health knowledge,self-efficacy and total score in two groups increased,and the scores of MRC and SGRQ decreased.The increasing degrees of the 6MWD,health knowledge,self-efficacy and total score in observation group were significantly more than those in control group(P<0.01),and the decreasing degrees of the MRC and SGRQ in observation group were significantly more than those in control group(P<0.01).Conclusions:Self-management intervention based on self-efficacy theory can effectively promote the recovery of patient with COPD,increase the awareness of the disease,improve self-management skill and quality of life,which is worthy of promotion.
Objective:To investigate the effects of self-management intervention based on self-efficacy theory in patient with chronic obstructive pulmonary disease(COPD),and provide the evidence in optimizing medical service.Methods:One hundred and twenty-eight patients with stabilization period COPD were randomly divided into the observation group and control group(64 cases each group).The control group were nursed with routine method,and the observation group was nursed with self-management intervention based on self-efficacy theory.The heart and lung function in two groups were evaluated using the 6 min walk distance(6MWD) and medical research council scale(MRC),and the health knowledge,self-efficacy and quality of life improvement in two groups were evaluated using health knowledge questionnaire,self-efficacy scale and St.George's respiratory questionnaire(SGRQ) before and after 8 weeks of intervention.Results:Before intervention,the differences of the scores of 6MWD,MRC,health knowledge questionnaire,self-efficacy scale and SGRQ between two groups were not statistically significant(P>0.05).After intervention,the scores of 6MWD,health knowledge,self-efficacy and total score in two groups increased,and the scores of MRC and SGRQ decreased.The increasing degrees of the 6MWD,health knowledge,self-efficacy and total score in observation group were significantly more than those in control group(P<0.01),and the decreasing degrees of the MRC and SGRQ in observation group were significantly more than those in control group(P<0.01).Conclusions:Self-management intervention based on self-efficacy theory can effectively promote the recovery of patient with COPD,increase the awareness of the disease,improve self-management skill and quality of life,which is worthy of promotion.
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