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2018 Vol. 43, No. 1
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2018, 43(1): 1-3.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.001
Abstract:
Objective:To analyze the properties,adipogenic and chondrogenic differentiation of adipose-derived stem cells in vitro.Methods:The abdominal adipose tissue of rabbit was harvested.The adipose-derived stem cells were isolated and cultured,and induced to adipogenic cells and cartilage cells in vitro.The adipogenic and chondrogenic differentiation of adipose-derived stem cells were identified using the oil red O staining,and type Ⅱ collagen immunohistochemical staining and Alcian Blue staining,respectively.Results:The adipose-derived stem cell was prismatic cells,and could stably passage.There was not the morphology difference in each generation cells.The results of oil red O staining found that the adipose-derived stem cells could form the positive lipid droplets,which demonstrated that the cells had adipogenic differentiation ability.The type Ⅱ collagen immunohistochemical staining and Alcian Blue staining showed that the adipose-derived stem cells could secrete the type Ⅱ collagen and sulfated proteoglycans,which demonstrated that the cells had the chondrogenic differentiation ability.Conclusions:The adipose-derived stem cells have the adipogenic and chondrogenic differentiation abilites which can become the seed cell of fat and cartilage tissue engineering.
Objective:To analyze the properties,adipogenic and chondrogenic differentiation of adipose-derived stem cells in vitro.Methods:The abdominal adipose tissue of rabbit was harvested.The adipose-derived stem cells were isolated and cultured,and induced to adipogenic cells and cartilage cells in vitro.The adipogenic and chondrogenic differentiation of adipose-derived stem cells were identified using the oil red O staining,and type Ⅱ collagen immunohistochemical staining and Alcian Blue staining,respectively.Results:The adipose-derived stem cell was prismatic cells,and could stably passage.There was not the morphology difference in each generation cells.The results of oil red O staining found that the adipose-derived stem cells could form the positive lipid droplets,which demonstrated that the cells had adipogenic differentiation ability.The type Ⅱ collagen immunohistochemical staining and Alcian Blue staining showed that the adipose-derived stem cells could secrete the type Ⅱ collagen and sulfated proteoglycans,which demonstrated that the cells had the chondrogenic differentiation ability.Conclusions:The adipose-derived stem cells have the adipogenic and chondrogenic differentiation abilites which can become the seed cell of fat and cartilage tissue engineering.
2018, 43(1): 4-7.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.002
Abstract:
Objective:To explore the expression of globular C1q receptor(gC1qR) and its biological significance.Methods:Thirty decidual tissue specimen of spontaneous abortion and 30 samples of induced abortion were collected,and extravillous cytotrophoblasts (EVCT)-derived transformed cell lines HTR-8/Svneo was investigated.The protein expression and location of gC1qR in decidual tissue were detected using immunohistochemical SP method,the expression levels of gC1qR protein and mRNA were detected using immunofluorescent staining and qRT-PCR,the apoptosis of trophoblast cells was evaluated using flow cytometry and electronic microscope.Results:The expression levels of gC1qR protein and mRNA in decidual tissue in spontaneous abortion patients were significantly higher than those in induced abortion patients(P<0.01).The overexpression of gC1qR could significantly increase the apoptosis rate of trophoblast cells(P<0.01),and the typical apoptosis morphological change was observed under electronic microscope.Conclusions:The gC1qR gene is closely related to spontaneous abortion,which is maybe to be an potential target point in the diagnosis,treatment and prevention of spontaneous abortion.
Objective:To explore the expression of globular C1q receptor(gC1qR) and its biological significance.Methods:Thirty decidual tissue specimen of spontaneous abortion and 30 samples of induced abortion were collected,and extravillous cytotrophoblasts (EVCT)-derived transformed cell lines HTR-8/Svneo was investigated.The protein expression and location of gC1qR in decidual tissue were detected using immunohistochemical SP method,the expression levels of gC1qR protein and mRNA were detected using immunofluorescent staining and qRT-PCR,the apoptosis of trophoblast cells was evaluated using flow cytometry and electronic microscope.Results:The expression levels of gC1qR protein and mRNA in decidual tissue in spontaneous abortion patients were significantly higher than those in induced abortion patients(P<0.01).The overexpression of gC1qR could significantly increase the apoptosis rate of trophoblast cells(P<0.01),and the typical apoptosis morphological change was observed under electronic microscope.Conclusions:The gC1qR gene is closely related to spontaneous abortion,which is maybe to be an potential target point in the diagnosis,treatment and prevention of spontaneous abortion.
2018, 43(1): 8-12.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.003
Abstract:
Objective:To investigate the effects of Kif15 on the proliferation,cell cycle and apoptosis of astrocytes in rat,and its mechanism.Methods:Astrocytes was isolated from one day old rat,the NC-siRNA and Kif15-siRNA were transfected into the cells,and the cells without any treatment was set as the control group.The expression levels of Kif15 protein in each group were detected using Western blotting after 48 h of transfection.The cell proliferation,cell cycle and apoptosis,and protein expression levels of PCNA,cyclinD1,Cleaved caspase3,p38 and p-p38 were detected using CCK8 assay,flow cytometry and Western blotting,respectively.Results:The expression level of Kif15 protein could be significantly inhibited in the cells transfected with Kif15-siRNA.Compared with the control group and NC-siRNA group,the cell survival rate,G2/M cells,and expression levels of PCNA,cyclinD1 and p-p38 proteins significantly decreased,the cell apoptosis rate,G1 cells and expression level of cleaved Caspase 3 protein significantly increased in Kif15-siRNA group(P<0.01),and the difference of the expression level of p38 between three groups was not statistically significant(P>0.05).Conclusions:The inhibiting of Kif15 in astrocytes can significantly reduce the proliferation of cells,block the cell in G1 phase and promote apoptosis,the mechanism of which is related to the inhibition of p38 signaling pathway.
Objective:To investigate the effects of Kif15 on the proliferation,cell cycle and apoptosis of astrocytes in rat,and its mechanism.Methods:Astrocytes was isolated from one day old rat,the NC-siRNA and Kif15-siRNA were transfected into the cells,and the cells without any treatment was set as the control group.The expression levels of Kif15 protein in each group were detected using Western blotting after 48 h of transfection.The cell proliferation,cell cycle and apoptosis,and protein expression levels of PCNA,cyclinD1,Cleaved caspase3,p38 and p-p38 were detected using CCK8 assay,flow cytometry and Western blotting,respectively.Results:The expression level of Kif15 protein could be significantly inhibited in the cells transfected with Kif15-siRNA.Compared with the control group and NC-siRNA group,the cell survival rate,G2/M cells,and expression levels of PCNA,cyclinD1 and p-p38 proteins significantly decreased,the cell apoptosis rate,G1 cells and expression level of cleaved Caspase 3 protein significantly increased in Kif15-siRNA group(P<0.01),and the difference of the expression level of p38 between three groups was not statistically significant(P>0.05).Conclusions:The inhibiting of Kif15 in astrocytes can significantly reduce the proliferation of cells,block the cell in G1 phase and promote apoptosis,the mechanism of which is related to the inhibition of p38 signaling pathway.
2018, 43(1): 13-15.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.004
Abstract:
Objective:To investigate the effects of downregulating the expression of p62 gene by shNA transfection on proliferation of cervical cancer HeLa cells.Methods:The lentiviral vector containing shRNA sequence of silencing p62 gene was constructed,and transfected into the cervical HeLa cells(shRNA group).The negative control group(shNC group) was set,and the non-lentiviral vector was set as blank control group.The expression levels of p62 mRNA,cell proliferation and cell colony formation rate in 3 groups were detected using qRT-PCR,CCK-8 assay and colony formation assay,respectively.Results:The lentiviral vector containing shRNA sequence of silencing p62 gene was successfully constructed.The expression of p62-mRNA in shRNA group and shNC group relative to the blank control group were (0.18±0.08) and (1.01±0.12),respectively.The interfere rate of shRNA was 81.00%.Compared with the negative control group and blank control group,the cell proliferation and colony formation rates in shRNA group were slow and little(P<0.05 and P<0.01),respectively.Conclusions:Silencing the expression of p62 gene can reduce the proliferation of cervical cancer HeLa cells.The p62 gene may play an important role in the proliferation of cervical cancer HeLa cells.
Objective:To investigate the effects of downregulating the expression of p62 gene by shNA transfection on proliferation of cervical cancer HeLa cells.Methods:The lentiviral vector containing shRNA sequence of silencing p62 gene was constructed,and transfected into the cervical HeLa cells(shRNA group).The negative control group(shNC group) was set,and the non-lentiviral vector was set as blank control group.The expression levels of p62 mRNA,cell proliferation and cell colony formation rate in 3 groups were detected using qRT-PCR,CCK-8 assay and colony formation assay,respectively.Results:The lentiviral vector containing shRNA sequence of silencing p62 gene was successfully constructed.The expression of p62-mRNA in shRNA group and shNC group relative to the blank control group were (0.18±0.08) and (1.01±0.12),respectively.The interfere rate of shRNA was 81.00%.Compared with the negative control group and blank control group,the cell proliferation and colony formation rates in shRNA group were slow and little(P<0.05 and P<0.01),respectively.Conclusions:Silencing the expression of p62 gene can reduce the proliferation of cervical cancer HeLa cells.The p62 gene may play an important role in the proliferation of cervical cancer HeLa cells.
2018, 43(1): 16-19.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.005
Abstract:
Objective:To investigate the relationship of blood glucose level and insulin dose in the treatment of type 2 diabetes (T2DM) with insulin pump.Methods:Total of 112 patients with T2DM were treated with insulin pump for 8 days.The levels of 8 times fingertip blood glucose every day,24 period base rate of insulin dosage,and large dose and total dose before three meals in all patients were analyzed using the linear correlation and multiple linear regression methods.Results:The levels of fasting and postprandial blood glucose were negatively correlated with the total amount of basal insulin.Conclusions:Basal insulin dose affects the levels of fasting and postprandial blood glucose,which is important in regulating the blood glucose.
Objective:To investigate the relationship of blood glucose level and insulin dose in the treatment of type 2 diabetes (T2DM) with insulin pump.Methods:Total of 112 patients with T2DM were treated with insulin pump for 8 days.The levels of 8 times fingertip blood glucose every day,24 period base rate of insulin dosage,and large dose and total dose before three meals in all patients were analyzed using the linear correlation and multiple linear regression methods.Results:The levels of fasting and postprandial blood glucose were negatively correlated with the total amount of basal insulin.Conclusions:Basal insulin dose affects the levels of fasting and postprandial blood glucose,which is important in regulating the blood glucose.
2018, 43(1): 20-22,26.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.006
Abstract:
Objective:To investigate the association of vitamin D(VitD)deficiency with dyslipidemia in schizophrenic patients.Methods:Two hundred twenty-nine patients with schizophrenia were choosed,information about demographic characteristics and life style were obtained through questionnaire,and fasting blood sample was collected and plasma concentrations of 25-hydroxyvitamin D[25(OH)D],total cholesterol (TC),triglycende(TG) and high deity lipoprotein-cholesterol(HDL-C) were measured.The association between VitD deficiency and lipid levels was assessed by χ2 test and logistic regression model.Results:The mean levels of 25(OH)D,TC,TG and HDL-C in schizophrenic patients were(45.9±21.3) nmol/L,(4.1±0.8) mmol/L,(1.2±0.7) mmol/L and(1.2±0.3) mmol/L,respectively.The incidences of VitD deficiency,dyslipidemia in TC,TG and HDL-C in schizophrenic patients were 60.3%,10.9%,15.7% and 34.1%,respectively.After controlling for confounders,compared with patients without VitD deficiency,the risk of dyslipidemia in TG (adjusted OR=2.80,95%CI 1.21-6.46) and HDL-C(adjusted OR=2.48,95%CI 1.35-4.56) significantly increased in patients with VitD deficiency.Conclusions:VitD deficiency may be associated with dyslipidemia in schizophrenic patients.
Objective:To investigate the association of vitamin D(VitD)deficiency with dyslipidemia in schizophrenic patients.Methods:Two hundred twenty-nine patients with schizophrenia were choosed,information about demographic characteristics and life style were obtained through questionnaire,and fasting blood sample was collected and plasma concentrations of 25-hydroxyvitamin D[25(OH)D],total cholesterol (TC),triglycende(TG) and high deity lipoprotein-cholesterol(HDL-C) were measured.The association between VitD deficiency and lipid levels was assessed by χ2 test and logistic regression model.Results:The mean levels of 25(OH)D,TC,TG and HDL-C in schizophrenic patients were(45.9±21.3) nmol/L,(4.1±0.8) mmol/L,(1.2±0.7) mmol/L and(1.2±0.3) mmol/L,respectively.The incidences of VitD deficiency,dyslipidemia in TC,TG and HDL-C in schizophrenic patients were 60.3%,10.9%,15.7% and 34.1%,respectively.After controlling for confounders,compared with patients without VitD deficiency,the risk of dyslipidemia in TG (adjusted OR=2.80,95%CI 1.21-6.46) and HDL-C(adjusted OR=2.48,95%CI 1.35-4.56) significantly increased in patients with VitD deficiency.Conclusions:VitD deficiency may be associated with dyslipidemia in schizophrenic patients.
2018, 43(1): 23-26.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.007
Abstract:
Objective:To investigate the clinical effects of stain endoscope combined with tumor biomarker in early diagnosis of colorectal cancer.Methods:According to Duck's staging,30 patients with stage Duck's A and B colorectal cancer were set as the observation group,and 30 colorectal polyp patients were set as the control group.The gene and protein expressions of carcinoembryonic antigen and Survivin in two groups were detected using RT-PCR and Western blotting,respectively.Results:Among 30 colorectal cancer patients,intramucosal adenocarcinom in 8 cases and adenocarcinoma in 22 cases were found,and stage Duck's A in 12 cases and stage Duck's B in 18 cases were identified after operation.The expression rates of carcinoembryonic antigen and Survivin at stage Duck's A were 25.00% and 27.78%,and the expression rates of carcinoembryonic antigen and Survivin at stage Duck's B were 41.67% and 55.56%.Among 30 polyp patients,canalicular adenoma in 22 cases,villous adenoma in 6 cases and tubulovillous adenoma in 2 cases were found.The expressions of carcinoembryonic antigen and Survivin in control group were not found,which was lower than that in observed group(P<0.05 to P<0.01).The expression rate of Survivin in observed group was significantly higher than that of carcinoembryonic antigen(P<0.01).Conclusions:The Survivin expression is high in early stage of colorectal cancer,which can set as a potential biomarker in combing with stain endoscope,and has important significance in the early diagnosis and treatment of colorectal cancer.
Objective:To investigate the clinical effects of stain endoscope combined with tumor biomarker in early diagnosis of colorectal cancer.Methods:According to Duck's staging,30 patients with stage Duck's A and B colorectal cancer were set as the observation group,and 30 colorectal polyp patients were set as the control group.The gene and protein expressions of carcinoembryonic antigen and Survivin in two groups were detected using RT-PCR and Western blotting,respectively.Results:Among 30 colorectal cancer patients,intramucosal adenocarcinom in 8 cases and adenocarcinoma in 22 cases were found,and stage Duck's A in 12 cases and stage Duck's B in 18 cases were identified after operation.The expression rates of carcinoembryonic antigen and Survivin at stage Duck's A were 25.00% and 27.78%,and the expression rates of carcinoembryonic antigen and Survivin at stage Duck's B were 41.67% and 55.56%.Among 30 polyp patients,canalicular adenoma in 22 cases,villous adenoma in 6 cases and tubulovillous adenoma in 2 cases were found.The expressions of carcinoembryonic antigen and Survivin in control group were not found,which was lower than that in observed group(P<0.05 to P<0.01).The expression rate of Survivin in observed group was significantly higher than that of carcinoembryonic antigen(P<0.01).Conclusions:The Survivin expression is high in early stage of colorectal cancer,which can set as a potential biomarker in combing with stain endoscope,and has important significance in the early diagnosis and treatment of colorectal cancer.
2018, 43(1): 27-29,33.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.008
Abstract:
Objective:To investigate the correlation between postpartum depression and urinary incontinence(UI).Methods:One thousand two hundred and sixty-three pregnant women were investigated using the relevant health questionnaire.The postpartum depression and UI were investigated at postpartum 12 weeks.The severity of UI and depressive symptoms were assessed using Sandvik index,and Edinburgh Postpartum Depression Scale(EPDS ≥ 10 as depression),respectively.Results:At postpartum 12 weeks,the UI in 121 women(14.8%) was diagnosed,which included 83 cases(68.6%) with mild UI,36 cases(29.8%) with moderate UI,and 2 cases(1.7%) with severe UI.Depression in 143 cases(14.8%) was identified.The incidence rate of depression in puerpera with UI(23.1%) was higher than that in puerpera without UI(13.7%)(P<0.05).Conclusions:The postpartum depression is related to the UI.
Objective:To investigate the correlation between postpartum depression and urinary incontinence(UI).Methods:One thousand two hundred and sixty-three pregnant women were investigated using the relevant health questionnaire.The postpartum depression and UI were investigated at postpartum 12 weeks.The severity of UI and depressive symptoms were assessed using Sandvik index,and Edinburgh Postpartum Depression Scale(EPDS ≥ 10 as depression),respectively.Results:At postpartum 12 weeks,the UI in 121 women(14.8%) was diagnosed,which included 83 cases(68.6%) with mild UI,36 cases(29.8%) with moderate UI,and 2 cases(1.7%) with severe UI.Depression in 143 cases(14.8%) was identified.The incidence rate of depression in puerpera with UI(23.1%) was higher than that in puerpera without UI(13.7%)(P<0.05).Conclusions:The postpartum depression is related to the UI.
2018, 43(1): 30-33.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.009
Abstract:
Objective:To investigate the effects of rehabilitation training on plasma tumor necrosis factor-like weak inducer of apoptosis(TWEAK) level in hypertensive stroke patients,and its predictive value in heart and lung functions.Methods:Eighty-two patients with hypertensive stroke were randomly divided into the control group and observation group(41 cases each group).The control group were treated with conventional therapy,and the observation group were additionally treated with rehabilitation training based on the control group.The plasma levels of TWEAK in two groups before and after treatment were detected using the enzyme-linked immunosorbent assay,and the heart and lung functions in two groups were evaluated using the NYHA functional test system and integrated cardiopulmonary evaluation system.Results:The difference of the level of TWEAK between two groups before treatment was not statistically significant(P>0.05),the levels of TWEAK in two groups significantly decreased after treatment(P<0.01),and which in observation group was significantly lower than that in control group(P<0.01).Compared before treatment,the FVC,FEV1,FEV1/FVC,MVV and MMEF in observation group significantly increased after treatment,and the RV,RV/TLC in observation group significantly decreased after treatment(P<0.01).Compared with before treatment,the MMEF in control group significantly increased,and the PV/TLC in control group significantly increased after treatment(P<0.01).After treatment,the levels of FVC,FEV1/FVC,MVV and MMEF in observation group were significantly higher than those in control group,and the levels of RV and RV/TLC in observation group were significantly lower than those in control group(P<0.01).After treatment,the difference of the cardiac functional grading between two groups after treatment was statistically significant(P<0.05).The TWEAK was correlation with FVC,FEV1/FVC,MVV,MMEF,RV,RV/TLC and NYHA(P<0.05 to P<0.01).Conclusions:The rehabilitation training can effectively reduce the plasma levels of TWEAK in hypertensive stroke patients.The plasma TWEAK is related to the NYHA cardiopulmonary function evaluation,which can be used as the predictor of the heart and lung function.
Objective:To investigate the effects of rehabilitation training on plasma tumor necrosis factor-like weak inducer of apoptosis(TWEAK) level in hypertensive stroke patients,and its predictive value in heart and lung functions.Methods:Eighty-two patients with hypertensive stroke were randomly divided into the control group and observation group(41 cases each group).The control group were treated with conventional therapy,and the observation group were additionally treated with rehabilitation training based on the control group.The plasma levels of TWEAK in two groups before and after treatment were detected using the enzyme-linked immunosorbent assay,and the heart and lung functions in two groups were evaluated using the NYHA functional test system and integrated cardiopulmonary evaluation system.Results:The difference of the level of TWEAK between two groups before treatment was not statistically significant(P>0.05),the levels of TWEAK in two groups significantly decreased after treatment(P<0.01),and which in observation group was significantly lower than that in control group(P<0.01).Compared before treatment,the FVC,FEV1,FEV1/FVC,MVV and MMEF in observation group significantly increased after treatment,and the RV,RV/TLC in observation group significantly decreased after treatment(P<0.01).Compared with before treatment,the MMEF in control group significantly increased,and the PV/TLC in control group significantly increased after treatment(P<0.01).After treatment,the levels of FVC,FEV1/FVC,MVV and MMEF in observation group were significantly higher than those in control group,and the levels of RV and RV/TLC in observation group were significantly lower than those in control group(P<0.01).After treatment,the difference of the cardiac functional grading between two groups after treatment was statistically significant(P<0.05).The TWEAK was correlation with FVC,FEV1/FVC,MVV,MMEF,RV,RV/TLC and NYHA(P<0.05 to P<0.01).Conclusions:The rehabilitation training can effectively reduce the plasma levels of TWEAK in hypertensive stroke patients.The plasma TWEAK is related to the NYHA cardiopulmonary function evaluation,which can be used as the predictor of the heart and lung function.
2018, 43(1): 34-36,39.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.010
Abstract:
Objective:To evaluate the correlations between red blood cell distribution width(RDW)and acute cerebral infarction and short-term(3 months) prognosis.Methods:Ninety patients with acute cerebral infarction and 30 healthy people were divided into cerebral infarction group and control group,respectively.The RDW in all cases were detected.The acute cerebral infarction group were divided into high RDW group(RDW>13.5%) and low RDW group(RDW ≤ 13.5%) according to the median of RDW.The National Institutes of Health Stroke Scale(NIHSS) scores in acute cerebral infarction patients when admitted to the hospital were evaluated,the functional recovery of patients after 3 months of acute cerebral infarction was evaluated using the modified Rankin scale(mRS).The acute cerebral infarction patients were divided into the good prognosis group(mRS ≤ 2 points) and poor prognosis group(mRS>2 points) according to the mRS scores.Results:The RDW in cerebral infarction group was significantly higher than that in control group(P<0.01).The NIHSS score in high RDW group was significantly higher than that in low RDW group(P<0.01).The RDW was significantly positive correlation with the NIHSS score(P<0.01).The RDW in poor prognosis group was significantly higher than that in good prognosis group(P<0.01).The area under the receiver operating characteristic(ROC) curve was 0.703 according to the RDW to identify the acute cerebral infarction,the optimal cut-off value,sensitivity and specificity were 12.9%,66.67% and 73.33%,respectively.The AUC of the short-term adverse prognosis was 0.831 according to the RDW to predict the acute cerebral infarction,and the critical point was more than 13.5%,the sensitivity and specificity were 88.46% and 71.87%,respectively.Conclusions:The RDW may be an important parameter in the diagnosis of acute cerebral infarction,which has a certain clinical reference value in assessing the severity and short-time prognosis of patients.
Objective:To evaluate the correlations between red blood cell distribution width(RDW)and acute cerebral infarction and short-term(3 months) prognosis.Methods:Ninety patients with acute cerebral infarction and 30 healthy people were divided into cerebral infarction group and control group,respectively.The RDW in all cases were detected.The acute cerebral infarction group were divided into high RDW group(RDW>13.5%) and low RDW group(RDW ≤ 13.5%) according to the median of RDW.The National Institutes of Health Stroke Scale(NIHSS) scores in acute cerebral infarction patients when admitted to the hospital were evaluated,the functional recovery of patients after 3 months of acute cerebral infarction was evaluated using the modified Rankin scale(mRS).The acute cerebral infarction patients were divided into the good prognosis group(mRS ≤ 2 points) and poor prognosis group(mRS>2 points) according to the mRS scores.Results:The RDW in cerebral infarction group was significantly higher than that in control group(P<0.01).The NIHSS score in high RDW group was significantly higher than that in low RDW group(P<0.01).The RDW was significantly positive correlation with the NIHSS score(P<0.01).The RDW in poor prognosis group was significantly higher than that in good prognosis group(P<0.01).The area under the receiver operating characteristic(ROC) curve was 0.703 according to the RDW to identify the acute cerebral infarction,the optimal cut-off value,sensitivity and specificity were 12.9%,66.67% and 73.33%,respectively.The AUC of the short-term adverse prognosis was 0.831 according to the RDW to predict the acute cerebral infarction,and the critical point was more than 13.5%,the sensitivity and specificity were 88.46% and 71.87%,respectively.Conclusions:The RDW may be an important parameter in the diagnosis of acute cerebral infarction,which has a certain clinical reference value in assessing the severity and short-time prognosis of patients.
2018, 43(1): 37-39.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.011
Abstract:
Objective:To investigate the effects of edaravone on patients with chronic obstructive pulmonary disease(COPD) complicated with cognitive dysfunction.Methods:Two hundred and eighteen patients with COPD complicated with cognitive dysfunction were randomly divided into the edaravone group(treated with edaravone combined with routine treatment) and routine treatment group.The MoCA scores,total treatment effect and effective rates in intent to treat population(ITT population) and per protocol population(PP population) between two groups before and after treatment were compared.Results:After treatment,the MoCA scores in two groups were significantly improved,especially for the edaravone group(P<0.05).The total treatment effect in edaravone group was better than that in routine treatment group(P<0.05).The difference of the effective rate between ITT population and PP population was not statistically significant(P>0.05).Conclusions:Edaravone can improve the cognitive function,and enhance the curative effect in patients with COPD complicated with cognitive impairment,
Objective:To investigate the effects of edaravone on patients with chronic obstructive pulmonary disease(COPD) complicated with cognitive dysfunction.Methods:Two hundred and eighteen patients with COPD complicated with cognitive dysfunction were randomly divided into the edaravone group(treated with edaravone combined with routine treatment) and routine treatment group.The MoCA scores,total treatment effect and effective rates in intent to treat population(ITT population) and per protocol population(PP population) between two groups before and after treatment were compared.Results:After treatment,the MoCA scores in two groups were significantly improved,especially for the edaravone group(P<0.05).The total treatment effect in edaravone group was better than that in routine treatment group(P<0.05).The difference of the effective rate between ITT population and PP population was not statistically significant(P>0.05).Conclusions:Edaravone can improve the cognitive function,and enhance the curative effect in patients with COPD complicated with cognitive impairment,
2018, 43(1): 40-42.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.012
Abstract:
Objective:To observe the effects of the timing of ambulation training on balance function and walking ability of hemiplegia patients with stroke.Methods:Sixty-eight hemiplegia patients with stroke were randomly divided into the observation group(n=34) and control group(n=34).The observation group were treated with scientific walking training under the condition of the high muscle tension at the early stage,and the control group were treated with scientific walking training under certain conditions,which included the standing balance more than grade 3,injured limb supporting over 3/4 of self-body weight,normal flex and adduct function of the knee joint and hip joint,and normal dorsiflexion function of ankle joint.The balance function,lower limb motor function,activities of daily living and walking ability in two groups were evaluated using the Berg balance scale(BBS),simple type Fugl-Meyer motor function scale(FMA),Bathel index(MBI) and Holden walking function rating(FAC) before training and after two months of training,respectively.The walking speed,stride length and stride frequency were measured using the max walking speed of 10m.Results:After 2 months of training,the scores of the BBS,FMA,MBI and FAC in two groups were significantly better than before treatment(P<0.01),the scores of the BBS,FMA,MBI and FAC in observation group were significantly higher those in control group(P<0.01),and the walking quality in observation group was better that in control group(P<0.05 to P<0.01).Conclusions:The timing of scientific walking training has important significance in the recovery of muscle tension in hemiplegia patients.The starting scientific walking training as early as possible can effectively improve the balance function,walking ability and living quality of patients.
Objective:To observe the effects of the timing of ambulation training on balance function and walking ability of hemiplegia patients with stroke.Methods:Sixty-eight hemiplegia patients with stroke were randomly divided into the observation group(n=34) and control group(n=34).The observation group were treated with scientific walking training under the condition of the high muscle tension at the early stage,and the control group were treated with scientific walking training under certain conditions,which included the standing balance more than grade 3,injured limb supporting over 3/4 of self-body weight,normal flex and adduct function of the knee joint and hip joint,and normal dorsiflexion function of ankle joint.The balance function,lower limb motor function,activities of daily living and walking ability in two groups were evaluated using the Berg balance scale(BBS),simple type Fugl-Meyer motor function scale(FMA),Bathel index(MBI) and Holden walking function rating(FAC) before training and after two months of training,respectively.The walking speed,stride length and stride frequency were measured using the max walking speed of 10m.Results:After 2 months of training,the scores of the BBS,FMA,MBI and FAC in two groups were significantly better than before treatment(P<0.01),the scores of the BBS,FMA,MBI and FAC in observation group were significantly higher those in control group(P<0.01),and the walking quality in observation group was better that in control group(P<0.05 to P<0.01).Conclusions:The timing of scientific walking training has important significance in the recovery of muscle tension in hemiplegia patients.The starting scientific walking training as early as possible can effectively improve the balance function,walking ability and living quality of patients.
2018, 43(1): 43-45.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.013
Abstract:
Objective:To study the change of serum lipid level in patients with chronic periodontitis complicated with high blood lipid after treatment.Methods:Sixty-five patients with chronic periodontitis complicated with high blood lipid were divided into the observation group(32 cases) and control group(33 cases).The control group was treated with oral hygiene guidance combined with scaling and polishing gum,and the observation group was treated with scaling root surface,flattening root,and rinsing the mouth with 0.2% compound Gargle solution daily within 2 weeks based on the control group.Results:Compared with before operation,the bleeding at probing technique in control group after 2 and 6 months of operation decreased(P<0.05 to P<0.01),and the bleeding and depth of probing technique,and clinical adhesion distance significantly decreased in observation group after 2 and 6 months of operation(P<0.01).The levels of total cholesterol,triglyceride,high density lipoprotein and low density cholesterol in control group between before operation and after 2 and 6 months of operation were not statistically significant(P>0.05).Compared with before operation,the levels of triglyceride and high density lipoprotein in observation group decreased and increased after 2 and 6 months of operation,respectively(P<0.05 to P<0.01).Conclusions:The treatment of periodontitis can effectively reduce the level of triglyceride,increase the level of high density lipoprotein,and improve the symptoms of high blood lipid,which is worthy of popularization in clinic.
Objective:To study the change of serum lipid level in patients with chronic periodontitis complicated with high blood lipid after treatment.Methods:Sixty-five patients with chronic periodontitis complicated with high blood lipid were divided into the observation group(32 cases) and control group(33 cases).The control group was treated with oral hygiene guidance combined with scaling and polishing gum,and the observation group was treated with scaling root surface,flattening root,and rinsing the mouth with 0.2% compound Gargle solution daily within 2 weeks based on the control group.Results:Compared with before operation,the bleeding at probing technique in control group after 2 and 6 months of operation decreased(P<0.05 to P<0.01),and the bleeding and depth of probing technique,and clinical adhesion distance significantly decreased in observation group after 2 and 6 months of operation(P<0.01).The levels of total cholesterol,triglyceride,high density lipoprotein and low density cholesterol in control group between before operation and after 2 and 6 months of operation were not statistically significant(P>0.05).Compared with before operation,the levels of triglyceride and high density lipoprotein in observation group decreased and increased after 2 and 6 months of operation,respectively(P<0.05 to P<0.01).Conclusions:The treatment of periodontitis can effectively reduce the level of triglyceride,increase the level of high density lipoprotein,and improve the symptoms of high blood lipid,which is worthy of popularization in clinic.
2018, 43(1): 46-48.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.014
Abstract:
Objective:To explore the value of the platelet count(PLT) and mean platelet volume(MPV) in evaluating the disease activity of ankylosing spondylitis(AS).Methods:The levels of PLT,MPV,scores of Bath ankylosing spondylitis disease activity index(BASDAI),erythrocyte sedimentation rate(ESR),C reactive protein(CRP),immunoglobulin(IgG) and hemoglobin(Hb) in 71 patients with AS were compared and analyzed.Results:Compared with the stable AS patients and control group,the PLT in active AS patients increased(P<0.01).Compared with the patients with normal PLT,the levels of ESR,CRP and IgG increased in patients with PLT increasing(P<0.01),but the levels of Hb and MPV decreased in patients with PLT increasing(P<0.05 and P<0.01).The level of PLT in AS patients was positively correlated with the levels of ESR,CRP and IgG(P<0.05 to P<0.01),and negatively correlated with the levels of Hb and MPV(P<0.01).Conclusions:The changes of PLT and MPV are associated with the disease activity of AS,which can be used as one of disease activity indicators in reflecting AS.
Objective:To explore the value of the platelet count(PLT) and mean platelet volume(MPV) in evaluating the disease activity of ankylosing spondylitis(AS).Methods:The levels of PLT,MPV,scores of Bath ankylosing spondylitis disease activity index(BASDAI),erythrocyte sedimentation rate(ESR),C reactive protein(CRP),immunoglobulin(IgG) and hemoglobin(Hb) in 71 patients with AS were compared and analyzed.Results:Compared with the stable AS patients and control group,the PLT in active AS patients increased(P<0.01).Compared with the patients with normal PLT,the levels of ESR,CRP and IgG increased in patients with PLT increasing(P<0.01),but the levels of Hb and MPV decreased in patients with PLT increasing(P<0.05 and P<0.01).The level of PLT in AS patients was positively correlated with the levels of ESR,CRP and IgG(P<0.05 to P<0.01),and negatively correlated with the levels of Hb and MPV(P<0.01).Conclusions:The changes of PLT and MPV are associated with the disease activity of AS,which can be used as one of disease activity indicators in reflecting AS.
2018, 43(1): 49-51,55.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.015
Abstract:
Objective:To evaluate the safety and feasibility of fast track surgery in elderly patients treated with laparoscopic colorectal cancer surgery.Methods:Thirty-two elderly colorectal cancer patients scheduled by laparoscopic radical colorectal resection were randomly divided into the quick recovery group(16 cases treated with perioperative FTS therapy) and conventional treatment group(16 cases treated with conventional perioperative therapy).The postoperative first flatus time,semi-liquid intake time,postoperative hospital stay,hospital expense,postoperative complications and stress,and nutrition index between two groups were compared.Results:The postoperative first flatus time,semi-liquid intake time,postoperative hospital stay and hospital expense in quick recovery group were better than those in conventional treatment group(P<0.05 to P<0.01),and the difference of the incidence rate of postoperative complication between two group was not statistically significant(P>0.05).The postoperative HOMA-IR index,and the serum levels of IL-6 and TNF-α in quick recovery group were significantly lower than those in conventional treatment group(P<0.05 to P<0.01),and the difference of cortisol level between two groups was not statistically significant(P>0.05).The differences of the levels of serum prealbumin and albumin between two group were not statistically significant(P>0.05).Conclusions:Fast track surgery in elderly colorectal cancer patients treated with laparoscopic radical resection is safe and effective.
Objective:To evaluate the safety and feasibility of fast track surgery in elderly patients treated with laparoscopic colorectal cancer surgery.Methods:Thirty-two elderly colorectal cancer patients scheduled by laparoscopic radical colorectal resection were randomly divided into the quick recovery group(16 cases treated with perioperative FTS therapy) and conventional treatment group(16 cases treated with conventional perioperative therapy).The postoperative first flatus time,semi-liquid intake time,postoperative hospital stay,hospital expense,postoperative complications and stress,and nutrition index between two groups were compared.Results:The postoperative first flatus time,semi-liquid intake time,postoperative hospital stay and hospital expense in quick recovery group were better than those in conventional treatment group(P<0.05 to P<0.01),and the difference of the incidence rate of postoperative complication between two group was not statistically significant(P>0.05).The postoperative HOMA-IR index,and the serum levels of IL-6 and TNF-α in quick recovery group were significantly lower than those in conventional treatment group(P<0.05 to P<0.01),and the difference of cortisol level between two groups was not statistically significant(P>0.05).The differences of the levels of serum prealbumin and albumin between two group were not statistically significant(P>0.05).Conclusions:Fast track surgery in elderly colorectal cancer patients treated with laparoscopic radical resection is safe and effective.
2018, 43(1): 52-55.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.016
Abstract:
Objective:To investigate the clinical value of hyperbaric oxygen in the treatment of viral encephalitis in children.Methods:Forty-six children with viral meningitis were randomly divided into the control group and observation group(23 cases each group).The control group and observation group were treated with routine method and hyperbaric oxygen based on routine method,respectively.The serum indicators related to neural function in two groups before treatment and 10 d,20 d and 30 d after treatment were detected,and the results of whose between two groups were compared.Results:The differences of the serum indicators related to neural function,peripheral blood T lymphocyte subsets and cerebral oxygen metabolism index between two groups before treatment were not statistically significant(P>0.05).After treatment,these indicators were improved to a certain degree(P<0.05 to P<0.01),and the results of indicators after 10 d,20 d and 30 d of treatment in observation group were better than those in control group(P<0.05).Conclusions:The clinical value of hyperbaric oxygen in the treatment of viral encephalitis is high,which can positively improve the neural function,immune function and cerebral oxygen metabolism of children.
Objective:To investigate the clinical value of hyperbaric oxygen in the treatment of viral encephalitis in children.Methods:Forty-six children with viral meningitis were randomly divided into the control group and observation group(23 cases each group).The control group and observation group were treated with routine method and hyperbaric oxygen based on routine method,respectively.The serum indicators related to neural function in two groups before treatment and 10 d,20 d and 30 d after treatment were detected,and the results of whose between two groups were compared.Results:The differences of the serum indicators related to neural function,peripheral blood T lymphocyte subsets and cerebral oxygen metabolism index between two groups before treatment were not statistically significant(P>0.05).After treatment,these indicators were improved to a certain degree(P<0.05 to P<0.01),and the results of indicators after 10 d,20 d and 30 d of treatment in observation group were better than those in control group(P<0.05).Conclusions:The clinical value of hyperbaric oxygen in the treatment of viral encephalitis is high,which can positively improve the neural function,immune function and cerebral oxygen metabolism of children.
2018, 43(1): 56-58,64.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.017
Abstract:
Objective:To compare the clinical effects between open surgery and arthroscopy in the treatment of calcific supraspinatus tendinitis.Methods:Thirty calcific supraspinatus tendinitis patients treated with operation were divided into the open surgery group(13 cases) and shoulder arthroscopy group(17 cases).The shoulder function recovery in two groups were evaluated by UCLA scoring system of the shoulder joint,Constant-Murley score,VAS pain score and simple shoulder test(SST) questionnaire before and after operation.Results:All patients were followed up for 7 to 27 months.The postoperative six indexes in two groups were significantly improved compared with before operation(P<0.01).The differences of the UCLA score,Constant-Murley score and VAS pain score between two groups were not statistically significant after operation(P>0.05).The flexion,abduction and SST questionnaire in shoulder arthroscopy group were better than those in open surgery group(P<0.01).Conclusions:The treatment of calcific supraspinatus tendinitis with shoulder arthroscopy can significantly improve the shoulder function,which has the advantage of minimal invasion,safety and quick recovery.
Objective:To compare the clinical effects between open surgery and arthroscopy in the treatment of calcific supraspinatus tendinitis.Methods:Thirty calcific supraspinatus tendinitis patients treated with operation were divided into the open surgery group(13 cases) and shoulder arthroscopy group(17 cases).The shoulder function recovery in two groups were evaluated by UCLA scoring system of the shoulder joint,Constant-Murley score,VAS pain score and simple shoulder test(SST) questionnaire before and after operation.Results:All patients were followed up for 7 to 27 months.The postoperative six indexes in two groups were significantly improved compared with before operation(P<0.01).The differences of the UCLA score,Constant-Murley score and VAS pain score between two groups were not statistically significant after operation(P>0.05).The flexion,abduction and SST questionnaire in shoulder arthroscopy group were better than those in open surgery group(P<0.01).Conclusions:The treatment of calcific supraspinatus tendinitis with shoulder arthroscopy can significantly improve the shoulder function,which has the advantage of minimal invasion,safety and quick recovery.
2018, 43(1): 59-64.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.018
Abstract:
Objective:To evaluate the efficacy and safety of the recombinant human brain natriuretic peptide (rhBNP) combined with Shenfu injection in treating acute myocardial infarction (AMI) complicated with acute heart failure (AHF).Methods:Sixty-two patients with AMI complicated with AHF were randomly divided into the rhBNP treatment group and rhBNP combined with Shenfu injection treatment group(combination group)(31 cases each group).The blood pressre,heart rate,24 hours urine output,dyspnea grade,plasma concentration of neuroendocrine hormone,ultrasonic cardiography parameters and incidence rate of adverse reaction between two groups before and after treatment were compared.Results:Compared with the rhBNP group,the differences of the diastolic pressure decreasing degree were not statistically significant(P>0.05),the 24 hours urine output increasing was obvious(P<0.01),the dyspnea improvement was significant(P<0.01),and the neuroendocrine hormone decreasing was obvious in combination group(P<0.01).After 6 months of treatment,the left ventricular ejection fraction significnatly increased(P<0.01),and the left ventricular end-diastolic dimension slightly decreased(P<0.05).Compared with the rhBNP group,the incidence rate of hypotension in combination group was lower(P<0.05).Under the SBP for 130 to 90 mmHg and DBP for 80 to 60 mmHg,no renal insufficiency or renal insufficiency aggravating in two groups was found.Conclusions:The rhBNP can effectively inhibit the activation of neuroendocrine hormone,and improve hemodynamics in patients with AMI complicated with AHF.The rhBNP combined with Shenfu injection can effectively improve the dyspnea,control heart failure,and promote the recovery left ventricular ejection fraction in patients with AMI complicated with AHF.
Objective:To evaluate the efficacy and safety of the recombinant human brain natriuretic peptide (rhBNP) combined with Shenfu injection in treating acute myocardial infarction (AMI) complicated with acute heart failure (AHF).Methods:Sixty-two patients with AMI complicated with AHF were randomly divided into the rhBNP treatment group and rhBNP combined with Shenfu injection treatment group(combination group)(31 cases each group).The blood pressre,heart rate,24 hours urine output,dyspnea grade,plasma concentration of neuroendocrine hormone,ultrasonic cardiography parameters and incidence rate of adverse reaction between two groups before and after treatment were compared.Results:Compared with the rhBNP group,the differences of the diastolic pressure decreasing degree were not statistically significant(P>0.05),the 24 hours urine output increasing was obvious(P<0.01),the dyspnea improvement was significant(P<0.01),and the neuroendocrine hormone decreasing was obvious in combination group(P<0.01).After 6 months of treatment,the left ventricular ejection fraction significnatly increased(P<0.01),and the left ventricular end-diastolic dimension slightly decreased(P<0.05).Compared with the rhBNP group,the incidence rate of hypotension in combination group was lower(P<0.05).Under the SBP for 130 to 90 mmHg and DBP for 80 to 60 mmHg,no renal insufficiency or renal insufficiency aggravating in two groups was found.Conclusions:The rhBNP can effectively inhibit the activation of neuroendocrine hormone,and improve hemodynamics in patients with AMI complicated with AHF.The rhBNP combined with Shenfu injection can effectively improve the dyspnea,control heart failure,and promote the recovery left ventricular ejection fraction in patients with AMI complicated with AHF.
2018, 43(1): 65-68.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.019
Abstract:
Objective:To investigate the influences of analgesic effect and sevoflurane anesthesia on the serum levels of ALT and AST,in cirrhosis patients treated with partial hepatectomy.Methods:Eighty cirrhotic patients were randomly divided into the sevoflurane anesthesia group(sevoflurane group,n=40) and propofol infusion anesthesia group(propofol group,n=40) according to the random number table.The serum levels of ALT and AST,and analgesic effects in two groups were statistically analyzed.Results:The spontaneous breathing recovery time,opening eye time and extubation time in sevoflurane group were significantly shorter than those in propofol group(P<0.01).The intranperative consumption amount of anesthetic drug per hour,maintaining cost and anesthetic drug cost in sevoflurane group were significantly lower than those in propofol group(P<0.01).The serum levels of ALT and AST in two groups significantly increased after operation(P<0.01),the differences of the serum levels of ALT and AST between two groups were not statistically significant after operation(P>0.05),and the VAS score in two groups significantly decreased after operation(P<0.01),and the VAS score in sevoflurane group was lower than that in propofol group after operation(P<0.01).Conclusions:The sevoflurane anesthesia do not increase the serum levels of ALT and AST and injure the liver in cirrhosis patients treated with partial hepatectomy,and the analgesic effect of which is good.
Objective:To investigate the influences of analgesic effect and sevoflurane anesthesia on the serum levels of ALT and AST,in cirrhosis patients treated with partial hepatectomy.Methods:Eighty cirrhotic patients were randomly divided into the sevoflurane anesthesia group(sevoflurane group,n=40) and propofol infusion anesthesia group(propofol group,n=40) according to the random number table.The serum levels of ALT and AST,and analgesic effects in two groups were statistically analyzed.Results:The spontaneous breathing recovery time,opening eye time and extubation time in sevoflurane group were significantly shorter than those in propofol group(P<0.01).The intranperative consumption amount of anesthetic drug per hour,maintaining cost and anesthetic drug cost in sevoflurane group were significantly lower than those in propofol group(P<0.01).The serum levels of ALT and AST in two groups significantly increased after operation(P<0.01),the differences of the serum levels of ALT and AST between two groups were not statistically significant after operation(P>0.05),and the VAS score in two groups significantly decreased after operation(P<0.01),and the VAS score in sevoflurane group was lower than that in propofol group after operation(P<0.01).Conclusions:The sevoflurane anesthesia do not increase the serum levels of ALT and AST and injure the liver in cirrhosis patients treated with partial hepatectomy,and the analgesic effect of which is good.
2018, 43(1): 70-72.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.021
Abstract:
Objective:To investigate the status of blood-borne occupational exposure and protection,and explore the measures to reduce the blood-borne occupational exposure of medical staff in operation room.Methods:Twenty-four medical staff with blood-borne occupational exposure in operation room were investigated,and the population distribution,generant step,exposure source and handle situation after exposure were analyzed.Results:Doctor was the main medical staff with blood-borne occupational exposure(70.83%),the ratios of blood-borne occupational exposure of medical staff with the age less than forty years,working year less than three years and more than or equal to nine years,and primary title were 79.17%,37.50%,33.33% and 54.17%,respectively.Hand was the main exposure part(91.67%),the thumb and middle fingers were more in the left hand,and the forefinger was more in right hand.The main way of blood-borne occupational exposure was sharp instrument injury(91.67%),and the ratios of the division,transfer and operation steps of surgical instrument during operation,and operation suture step were 45.83% and 37.50%,respectively.The HBV was the main pathogen of exposure(83.33%).All medical staff with blood-borne occupational exposure were immediately treated after exposure in local,the correct rate of local treatment was 83.33%.Eighty medical staff were treated with preventive medication after exposure(75.00%),the main treatment way was the HBIG combined with hepatitis B vaccine,and second HBIG therapy.Conclusions:Definiting the high risk population,main step and sharp instrument of blood-borne occupational exposure in operation room,standardizing operating procedure,necessary protective equipment and right treatment after exposure can reduce the risk of blood-borne occupational exposure and infection after exposure.
Objective:To investigate the status of blood-borne occupational exposure and protection,and explore the measures to reduce the blood-borne occupational exposure of medical staff in operation room.Methods:Twenty-four medical staff with blood-borne occupational exposure in operation room were investigated,and the population distribution,generant step,exposure source and handle situation after exposure were analyzed.Results:Doctor was the main medical staff with blood-borne occupational exposure(70.83%),the ratios of blood-borne occupational exposure of medical staff with the age less than forty years,working year less than three years and more than or equal to nine years,and primary title were 79.17%,37.50%,33.33% and 54.17%,respectively.Hand was the main exposure part(91.67%),the thumb and middle fingers were more in the left hand,and the forefinger was more in right hand.The main way of blood-borne occupational exposure was sharp instrument injury(91.67%),and the ratios of the division,transfer and operation steps of surgical instrument during operation,and operation suture step were 45.83% and 37.50%,respectively.The HBV was the main pathogen of exposure(83.33%).All medical staff with blood-borne occupational exposure were immediately treated after exposure in local,the correct rate of local treatment was 83.33%.Eighty medical staff were treated with preventive medication after exposure(75.00%),the main treatment way was the HBIG combined with hepatitis B vaccine,and second HBIG therapy.Conclusions:Definiting the high risk population,main step and sharp instrument of blood-borne occupational exposure in operation room,standardizing operating procedure,necessary protective equipment and right treatment after exposure can reduce the risk of blood-borne occupational exposure and infection after exposure.
2018, 43(1): 73-77.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.022
Abstract:
Objective:To explore the genotype of α-thalassemia and relationship with hematological indictors in Southwestern Area of Guizhou province.Methods:A total of 209 patients with α-thalassemia in southwestern area of Guizhou province were set as the α-thalassemia group,which included silent thalassemia in 51 cases,standard thalassemia in 92 cases and intermediate thalassemia in 66 casess accorded to the a-Globin genotype.Fifty healthy people were set as the control group.The red blood cell(RBC) count,hemoglobin(Hb),mean cell volume(MCV),mean corpuscular hemoglobin(MCH) mean corpusular hemoglobin concerntration(MCHC),red cell distribution width(RCDW),hemoglobinA2(HbA2) and hemoglobin F(HbF) between two groups were compared.Results:Among 209 α-thalassemia patients,the deletion type(--or-α) in 182 cases(87.1%) and non-deletion type(αTα) in 27 cases(12.9%) were identified.The levels of RBC and RCDW in α-thalassemia group were higher than those in control group,the levels of Hb,MCV,MCH,MCHC and HbA2 in α-thalassemia group were lower than those in control group(P<0.05).Among α-thalassemia patients,the levels of Hb,MCV,MCH,MCHC and HbA2 showed a decreasing trend,the level of RCDW showed a increasing trend,the level of RBC showed the decreasing trend at first,and then increasing trend,and the difference of whcih between each group was statistically significant(P<0.05).The level of MCHC in -α3.7/αα subgroup was higher than that in -α4.2/αα subgroup and αTα/αα subgroup,the level of MCHC in -α4.2/αα subgroup was higher than that in αTα/αα subgroup,and the difference of which between each group was statistically significant(P<0.05).The level of MCV in αTα/--SEA subgroup was higher than that in -α3.7/--SEA subgroup and -α4.2/--SEA subgroup,and the level of MCHC in αTα/--SEA subgroup was lower than that in -α3.7/--SEA subgroup and -α4.2/--SEA subgroup(P<0.05).Conclusions:The--SEA/αα type is the main genotype of α-thalassemia in southwestern area,and the hematological indictors can be used as one of the indicator in screening α-thalassemia.
Objective:To explore the genotype of α-thalassemia and relationship with hematological indictors in Southwestern Area of Guizhou province.Methods:A total of 209 patients with α-thalassemia in southwestern area of Guizhou province were set as the α-thalassemia group,which included silent thalassemia in 51 cases,standard thalassemia in 92 cases and intermediate thalassemia in 66 casess accorded to the a-Globin genotype.Fifty healthy people were set as the control group.The red blood cell(RBC) count,hemoglobin(Hb),mean cell volume(MCV),mean corpuscular hemoglobin(MCH) mean corpusular hemoglobin concerntration(MCHC),red cell distribution width(RCDW),hemoglobinA2(HbA2) and hemoglobin F(HbF) between two groups were compared.Results:Among 209 α-thalassemia patients,the deletion type(--or-α) in 182 cases(87.1%) and non-deletion type(αTα) in 27 cases(12.9%) were identified.The levels of RBC and RCDW in α-thalassemia group were higher than those in control group,the levels of Hb,MCV,MCH,MCHC and HbA2 in α-thalassemia group were lower than those in control group(P<0.05).Among α-thalassemia patients,the levels of Hb,MCV,MCH,MCHC and HbA2 showed a decreasing trend,the level of RCDW showed a increasing trend,the level of RBC showed the decreasing trend at first,and then increasing trend,and the difference of whcih between each group was statistically significant(P<0.05).The level of MCHC in -α3.7/αα subgroup was higher than that in -α4.2/αα subgroup and αTα/αα subgroup,the level of MCHC in -α4.2/αα subgroup was higher than that in αTα/αα subgroup,and the difference of which between each group was statistically significant(P<0.05).The level of MCV in αTα/--SEA subgroup was higher than that in -α3.7/--SEA subgroup and -α4.2/--SEA subgroup,and the level of MCHC in αTα/--SEA subgroup was lower than that in -α3.7/--SEA subgroup and -α4.2/--SEA subgroup(P<0.05).Conclusions:The--SEA/αα type is the main genotype of α-thalassemia in southwestern area,and the hematological indictors can be used as one of the indicator in screening α-thalassemia.
2018, 43(1): 78-80.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.023
Abstract:
Objective:To detect the serum levels of interleukin(IL)-37 and IL-33 in children with hand-foot-mouth disease(HFMD) caused by enterovirus 71 infection,and analyze its clinical significance.Methods:The absolute values of peripheral blood neutrophils and monocytes,and serum levels of IL-37 and IL-37 in 180 children with HFMD infected by EV71(observation group) and 100 healthy children(control group) were detected using the automatic blood cell analyzer and ELISA,respectively,and the correlations were analyzed.Results:The absolute values of neutrophils and monocytes,and serum levels of IL-37 and IL-33 in observation group were significantly higher than those in control group(P<0.01).The absolute values of neutrophils and monocytes,and serum level of IL-37 in children with severe EV71 infection were higher than those in mild EV71 infection children(P<0.05 to P<0.01).The serum levels of IL-37 in observation group were positive correlation with the serum level of IL-33(P<0.05).In severe group,the serum level of IL-37 was positively correlated to the absolute value of monocytes(P<0.05),and the serum level of IL-33 was positively correlated to the absolute value of neutrophils(P<0.05).Conclusions:The changes of IL-37 and IL-33 levels in children with HFMD infected by EV71 may be related to the pathogenesis of HFMD.
Objective:To detect the serum levels of interleukin(IL)-37 and IL-33 in children with hand-foot-mouth disease(HFMD) caused by enterovirus 71 infection,and analyze its clinical significance.Methods:The absolute values of peripheral blood neutrophils and monocytes,and serum levels of IL-37 and IL-37 in 180 children with HFMD infected by EV71(observation group) and 100 healthy children(control group) were detected using the automatic blood cell analyzer and ELISA,respectively,and the correlations were analyzed.Results:The absolute values of neutrophils and monocytes,and serum levels of IL-37 and IL-33 in observation group were significantly higher than those in control group(P<0.01).The absolute values of neutrophils and monocytes,and serum level of IL-37 in children with severe EV71 infection were higher than those in mild EV71 infection children(P<0.05 to P<0.01).The serum levels of IL-37 in observation group were positive correlation with the serum level of IL-33(P<0.05).In severe group,the serum level of IL-37 was positively correlated to the absolute value of monocytes(P<0.05),and the serum level of IL-33 was positively correlated to the absolute value of neutrophils(P<0.05).Conclusions:The changes of IL-37 and IL-33 levels in children with HFMD infected by EV71 may be related to the pathogenesis of HFMD.
2018, 43(1): 81-83.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.024
Abstract:
Objective:To investigate the correlation between mean platelet volume/platelet ratio(MPR) and systemic lupus erythematosus(SLE).Methods:Thirty-six SLE patients and 40 age-and gender-matched medical examiner were divided into the SLE group and control group,respectively.The MPV,MPR,SLE disease activity index(SLEDAI) and erythrocyte sedimentation rate(ESR) were retrospectively analyzed.Results:The levels of MPV and MPR in SLE group were higher than those in control group(P<0.05 and P<0.01).The ESR was positively correlated with MPV and MPR(P<0.01 and P<0.05).The MPR was positively correlated with SLEDAI(P<0.01),and the MPV was not obviously correlated with SLEDAI(P>0.05).Conclusions:MPR may be an useful index in estimating the SLE activity.
Objective:To investigate the correlation between mean platelet volume/platelet ratio(MPR) and systemic lupus erythematosus(SLE).Methods:Thirty-six SLE patients and 40 age-and gender-matched medical examiner were divided into the SLE group and control group,respectively.The MPV,MPR,SLE disease activity index(SLEDAI) and erythrocyte sedimentation rate(ESR) were retrospectively analyzed.Results:The levels of MPV and MPR in SLE group were higher than those in control group(P<0.05 and P<0.01).The ESR was positively correlated with MPV and MPR(P<0.01 and P<0.05).The MPR was positively correlated with SLEDAI(P<0.01),and the MPV was not obviously correlated with SLEDAI(P>0.05).Conclusions:MPR may be an useful index in estimating the SLE activity.
2018, 43(1): 84-86,89.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.025
Abstract:
Objective:To analyze the results of thrombelastography(TEG) in cardia-cerebrovascular disease patients treated with antiplatelet,and provide the reference for clinical therapy.Methods:Two hundred and forty-nine cardia-cerebrovascular disease patients were divided into the aspirin group(group AA,141cases),clopidogrel group(group ADP,20 cases) and aspirin and clopidogrel combination group(combination group,88 cases) according to the use of antiplatelet agent.The platelet inhibition rates in three groups were detected by thromboelastography,and the differences of the efficacy of antiplatelet treatment between three groups were compared.Results:The platelet inhibition rates in combination group induced by AA and ADP receptor pathway were (88.47±19.69)% and (68.08±28.12)%,respectively,which was higher than that in group AA[(77.71±29.7)%] and in group ADP[(52.57±26.97)%](P<0.01 and P<0.05).The incidence rates of aspirin and clopidogrel resistance in combination group were 6.82% and 11.36%,respectively,which was lower than that in group AA(21.99%) and group ADP(30%)(P<0.01 and P>0.05).Conclusions:The inhibition rate of platelet aggregation detected by using TEG is helpful to formulate individualized antiplatelet therapy in cardia-cerebrovascular disease patients.The effect of aspirin on the inhibition of platelet aggregation in cardia-cerebrovascular disease patients is higher than that of clopidogrel.Antiplatelet resistance is found in patients treated with standard dose of antiplatelet therapy.There is a synergistic effect in the combination use of asprin and clopidogrel in antiplatelet therapy.
Objective:To analyze the results of thrombelastography(TEG) in cardia-cerebrovascular disease patients treated with antiplatelet,and provide the reference for clinical therapy.Methods:Two hundred and forty-nine cardia-cerebrovascular disease patients were divided into the aspirin group(group AA,141cases),clopidogrel group(group ADP,20 cases) and aspirin and clopidogrel combination group(combination group,88 cases) according to the use of antiplatelet agent.The platelet inhibition rates in three groups were detected by thromboelastography,and the differences of the efficacy of antiplatelet treatment between three groups were compared.Results:The platelet inhibition rates in combination group induced by AA and ADP receptor pathway were (88.47±19.69)% and (68.08±28.12)%,respectively,which was higher than that in group AA[(77.71±29.7)%] and in group ADP[(52.57±26.97)%](P<0.01 and P<0.05).The incidence rates of aspirin and clopidogrel resistance in combination group were 6.82% and 11.36%,respectively,which was lower than that in group AA(21.99%) and group ADP(30%)(P<0.01 and P>0.05).Conclusions:The inhibition rate of platelet aggregation detected by using TEG is helpful to formulate individualized antiplatelet therapy in cardia-cerebrovascular disease patients.The effect of aspirin on the inhibition of platelet aggregation in cardia-cerebrovascular disease patients is higher than that of clopidogrel.Antiplatelet resistance is found in patients treated with standard dose of antiplatelet therapy.There is a synergistic effect in the combination use of asprin and clopidogrel in antiplatelet therapy.
2018, 43(1): 87-89.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.026
Abstract:
Objective:To investigate the predictive value of the neutrophil to lymphocyte ratio(NLR) and cystatin C(CysC) in early renal damage of type 2 diabetes patients.Methods:One hundred and eighty-two type 2 diabetes patients were divided into the simple diabetes group[albumin to creatinine(ACR)<3.4 mg/mmol] and early diabetic nephropathy group(3.4 ≤ ACR<33.9 mg/mmol) according to the urinary ACR ratio.The levels of gender,age,duration of diabetes,whole blood NLR,serum urea(UREA),creatinine(CREA),uric acid(UA) and CysC between two groups were compared,and analyzed using the receiver operating curve(ROC) and logistic regression.Results:The differences of the gender,duration of diabetes,and serum levels of UREA,CREA and UA between two groups were not statistically significant(P>0.05),but the age,whole blood NLR and serum level of CysC in early diabetic nephropathy group were higher than those in simple diabetic group(P< 0.05 to P<0.01).The diagnostic value of serum CysC in early diabetic nephropathy was higher than that of age and whole blood NLR.The area under ROC curve of CysC,age and whole blood NLR were 0.831,0.678 and 0.638,respectively,the sensitivities of CysC,age and whole blood NLR were 70.59%,92.86% and 92.86%,respectively,the specificities of CysC,age and whole blood NLR were 90.00%,41.27% and 36.51%,respectively,the negative predictive values of CysC,age and whole blood NLR were 84.36%,92.85% and 91.99%,respectively,and the positive predictive values of CysC,age and whole blood NLR were 80.02%,41.31% and 39.43%,respectively.Serum CysC was a risk factor in early diabetic nephropathy,and the odds ratio of which was 266.080.Conclusions:Age and whole blood NLR can be set as a screening index for early diabetic nephropathy.The serum CysC has highly predictive value,which is an independent risk factor in early diabetic nephropathy.
Objective:To investigate the predictive value of the neutrophil to lymphocyte ratio(NLR) and cystatin C(CysC) in early renal damage of type 2 diabetes patients.Methods:One hundred and eighty-two type 2 diabetes patients were divided into the simple diabetes group[albumin to creatinine(ACR)<3.4 mg/mmol] and early diabetic nephropathy group(3.4 ≤ ACR<33.9 mg/mmol) according to the urinary ACR ratio.The levels of gender,age,duration of diabetes,whole blood NLR,serum urea(UREA),creatinine(CREA),uric acid(UA) and CysC between two groups were compared,and analyzed using the receiver operating curve(ROC) and logistic regression.Results:The differences of the gender,duration of diabetes,and serum levels of UREA,CREA and UA between two groups were not statistically significant(P>0.05),but the age,whole blood NLR and serum level of CysC in early diabetic nephropathy group were higher than those in simple diabetic group(P< 0.05 to P<0.01).The diagnostic value of serum CysC in early diabetic nephropathy was higher than that of age and whole blood NLR.The area under ROC curve of CysC,age and whole blood NLR were 0.831,0.678 and 0.638,respectively,the sensitivities of CysC,age and whole blood NLR were 70.59%,92.86% and 92.86%,respectively,the specificities of CysC,age and whole blood NLR were 90.00%,41.27% and 36.51%,respectively,the negative predictive values of CysC,age and whole blood NLR were 84.36%,92.85% and 91.99%,respectively,and the positive predictive values of CysC,age and whole blood NLR were 80.02%,41.31% and 39.43%,respectively.Serum CysC was a risk factor in early diabetic nephropathy,and the odds ratio of which was 266.080.Conclusions:Age and whole blood NLR can be set as a screening index for early diabetic nephropathy.The serum CysC has highly predictive value,which is an independent risk factor in early diabetic nephropathy.
2018, 43(1): 90-95.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.027
Abstract:
Objective:To explore the teaching effects of the curriculum reform of "ultrasonic diagnostics" in medical imaging major.Methods:A total of 178 undergraduates in grade 2013 and 185 undergraduates in grade 2012 in department of medical imaging of Bengbu Medical College were divided into the experimental group and control group,respectively.The experimental group and control group were taught using the curriculum reform of "ultrasonic diagnostics" and traditional teaching system,respectively.The teaching effects and satisfaction degree in experimental group were evaluated using the examination and questionnaire.Results:The scores of theory test,experiment skill and clinical thinking ability in experimental group were significantly higher than those in control group(P<0.01).The satisfaction degrees of learning quality,learning interest,abilities of autonomous learning,solving problem,clinical thinking,scientific research innovation,communication,teamwork in experimental group were significantly better than those in control group(P<0.01).Conclusions:The application of the curriculum reform of "ultrasonic diagnostics" can play an important role in cultivating the innovative and practical medical imaging talents.
Objective:To explore the teaching effects of the curriculum reform of "ultrasonic diagnostics" in medical imaging major.Methods:A total of 178 undergraduates in grade 2013 and 185 undergraduates in grade 2012 in department of medical imaging of Bengbu Medical College were divided into the experimental group and control group,respectively.The experimental group and control group were taught using the curriculum reform of "ultrasonic diagnostics" and traditional teaching system,respectively.The teaching effects and satisfaction degree in experimental group were evaluated using the examination and questionnaire.Results:The scores of theory test,experiment skill and clinical thinking ability in experimental group were significantly higher than those in control group(P<0.01).The satisfaction degrees of learning quality,learning interest,abilities of autonomous learning,solving problem,clinical thinking,scientific research innovation,communication,teamwork in experimental group were significantly better than those in control group(P<0.01).Conclusions:The application of the curriculum reform of "ultrasonic diagnostics" can play an important role in cultivating the innovative and practical medical imaging talents.
2018, 43(1): 98-101.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.029
Abstract:
Objective:To explore the feasibility of family combined nursing in optimizing the quality of life in patients with myocardial infarction after discharge.Methods:A total of 68 patients with acute myocardial infarction after discharge were randomly divided into the control group and observation group(34 cases each group).The control group were nursed with routine care,and the observation group were nursed with family combined nursing after discharge.The life quality,disease condition,levels of depression and anxiety in two groups were evaluated using the MOS item short from health survey(SF-36),settle angina questionnair,self-rating depression scale(SDS) and Self-rating anxiety scale(SAS),respectively.Results:The scores of physical function,role limitation caused by physical function,overall health assessment,vitality,role limitation caused by emotion and mental health in observation group were significantly higher than those in control group(P<0.01),and the differences of the scores of pain and social function between two groups were not statistically significant(P>0.05).The scores of physical activities,treatment satisfaction and disease cognition in observation group were significantly than higher those in control group(P<0.01),and the differences of the scores of angina pectoris and stability between two groups were not statistically significant(P>0.05).The scores of SDS and SAS in observation group were significantly than lower those in control group(P<0.01).Conclusions:The family combined nursing can not reduce the recurrence of angina pectoris in patients with myocardial infarction,but which can effectively improve the quality of life,and relieve anxiety and depression of patients after discharge.
Objective:To explore the feasibility of family combined nursing in optimizing the quality of life in patients with myocardial infarction after discharge.Methods:A total of 68 patients with acute myocardial infarction after discharge were randomly divided into the control group and observation group(34 cases each group).The control group were nursed with routine care,and the observation group were nursed with family combined nursing after discharge.The life quality,disease condition,levels of depression and anxiety in two groups were evaluated using the MOS item short from health survey(SF-36),settle angina questionnair,self-rating depression scale(SDS) and Self-rating anxiety scale(SAS),respectively.Results:The scores of physical function,role limitation caused by physical function,overall health assessment,vitality,role limitation caused by emotion and mental health in observation group were significantly higher than those in control group(P<0.01),and the differences of the scores of pain and social function between two groups were not statistically significant(P>0.05).The scores of physical activities,treatment satisfaction and disease cognition in observation group were significantly than higher those in control group(P<0.01),and the differences of the scores of angina pectoris and stability between two groups were not statistically significant(P>0.05).The scores of SDS and SAS in observation group were significantly than lower those in control group(P<0.01).Conclusions:The family combined nursing can not reduce the recurrence of angina pectoris in patients with myocardial infarction,but which can effectively improve the quality of life,and relieve anxiety and depression of patients after discharge.
2018, 43(1): 101-103.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.030
Abstract:
Objective:To investigate the nursing effects of humane care nursing mode on glioma patients.Methods:Sixty-two patients with glioma were randomly divided into the control group and observation group(31 cases each group).The control group and observation group were nursed with routine care and humane care nursing mode,respectively.The hope index,mentality state and quality of life in two groups were evaluated after intervention.Results:Compared with before intervention,the three dimension scores of hope level scale in two groups significantly increased after intervention(P<0.01),and the increasing degree of which in observation group was higher than that in control group(P<0.01).Compared with before intervention,the scores of self rating anxiety scale,self rating depression scale and dysfunctional attitude questionnaire in two groups significantly decreased after intervention(P<0.01),and the decreasing degree of which in observation group was more obvious than that in control group(P<0.01).After intervention,the scores of psychological and emotional state,physical function and daily life in observation group were significantly higher than those in control group(P<0.05 to P<0.01),but the difference of the score of social activity between two groups was not statistically significant(P>0.05).Conclusions:The humane care nursing mode can significantly improve the hope level scale index,anxiety,depression and quality of life,which is a good way to improve the quality of care in glioma patients.
Objective:To investigate the nursing effects of humane care nursing mode on glioma patients.Methods:Sixty-two patients with glioma were randomly divided into the control group and observation group(31 cases each group).The control group and observation group were nursed with routine care and humane care nursing mode,respectively.The hope index,mentality state and quality of life in two groups were evaluated after intervention.Results:Compared with before intervention,the three dimension scores of hope level scale in two groups significantly increased after intervention(P<0.01),and the increasing degree of which in observation group was higher than that in control group(P<0.01).Compared with before intervention,the scores of self rating anxiety scale,self rating depression scale and dysfunctional attitude questionnaire in two groups significantly decreased after intervention(P<0.01),and the decreasing degree of which in observation group was more obvious than that in control group(P<0.01).After intervention,the scores of psychological and emotional state,physical function and daily life in observation group were significantly higher than those in control group(P<0.05 to P<0.01),but the difference of the score of social activity between two groups was not statistically significant(P>0.05).Conclusions:The humane care nursing mode can significantly improve the hope level scale index,anxiety,depression and quality of life,which is a good way to improve the quality of care in glioma patients.
2018, 43(1): 104-106.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.031
Abstract:
Objective:To explore the application effects of knowledge-society-psychology model in the rehabilitation of mental and physical disorders in patients with stroke.Methods:Ninety-six stroke patients were divided into the observation group(n=48) and control group(n=48) according to the random number table.The control group and observation group were nursed with routine model and knowledge-society-psychology model,respectively.The psychological status in two groups were evaluated using the self-rating anxiety scale(SAS) and self-rating depression scale(SDS) before and after the intervention.The physical condition and quality of life in two groups were evaluated using Fugl-Meyer and stroke impact scale(SIS).Results:The scores of SAS and SDS in observation group were significantly lower than those in control group after intervention(P<0.01).The motor function scores of the upper and lower limbs in observation group after intervention were significantly higher than those than in control group(P<0.01).The SIS score in observation group after intervention significantly increased compared with control group(P<0.01).Conclusions:The knowledge-society-psychology model can improve the psychological status,motor function and quality of life of patients with stroke.
Objective:To explore the application effects of knowledge-society-psychology model in the rehabilitation of mental and physical disorders in patients with stroke.Methods:Ninety-six stroke patients were divided into the observation group(n=48) and control group(n=48) according to the random number table.The control group and observation group were nursed with routine model and knowledge-society-psychology model,respectively.The psychological status in two groups were evaluated using the self-rating anxiety scale(SAS) and self-rating depression scale(SDS) before and after the intervention.The physical condition and quality of life in two groups were evaluated using Fugl-Meyer and stroke impact scale(SIS).Results:The scores of SAS and SDS in observation group were significantly lower than those in control group after intervention(P<0.01).The motor function scores of the upper and lower limbs in observation group after intervention were significantly higher than those than in control group(P<0.01).The SIS score in observation group after intervention significantly increased compared with control group(P<0.01).Conclusions:The knowledge-society-psychology model can improve the psychological status,motor function and quality of life of patients with stroke.
2018, 43(1): 107-109,113.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.032
Abstract:
Objective:To evaluate the clinical significance of the combined rehabilitative care(including pain management,emotional management and rehabilitation paths) in minimally invasive surgery treatment of lumbar disc herniation.Methods:Eighty-six lumbar disc herniation patients treated with minimally invasive surgery were randomly divided into the control group and observation group(43 cases each group).The control group and observation group were nursed with routine rehabilitation nursing care and combined rehabilitative care,respectively.The emotion,pain and lumbar vertebra and spine function in two groups before and after intervention were compared.Results:Before intervention,the differences of the scores of Hamilton Depression Scale(HAMD) and visual analog score(VAS) between two groups were not statistically significant(P>0.05).After intervention,the scores of HAMD and VAS in observation group were lower than those in control group(P<0.01).Before intervention,the differences of the scores of ODI and JOA between two groups were not statistically significant(P>0.05).Compared with the control group,the score of ODI in observation group after intervention obviously decreased,and the score of JOA in observation group after intervention was obviously high(P<0.01).Conclusions:The combined rehabilitative care in minimally invasive surgery treatment of lumbar disc herniation can significantly reduce unhealthy psychological mood and level of pain,and improve the rehabilitation compliance and security of patients,which is worthy of popularization in clinic.
Objective:To evaluate the clinical significance of the combined rehabilitative care(including pain management,emotional management and rehabilitation paths) in minimally invasive surgery treatment of lumbar disc herniation.Methods:Eighty-six lumbar disc herniation patients treated with minimally invasive surgery were randomly divided into the control group and observation group(43 cases each group).The control group and observation group were nursed with routine rehabilitation nursing care and combined rehabilitative care,respectively.The emotion,pain and lumbar vertebra and spine function in two groups before and after intervention were compared.Results:Before intervention,the differences of the scores of Hamilton Depression Scale(HAMD) and visual analog score(VAS) between two groups were not statistically significant(P>0.05).After intervention,the scores of HAMD and VAS in observation group were lower than those in control group(P<0.01).Before intervention,the differences of the scores of ODI and JOA between two groups were not statistically significant(P>0.05).Compared with the control group,the score of ODI in observation group after intervention obviously decreased,and the score of JOA in observation group after intervention was obviously high(P<0.01).Conclusions:The combined rehabilitative care in minimally invasive surgery treatment of lumbar disc herniation can significantly reduce unhealthy psychological mood and level of pain,and improve the rehabilitation compliance and security of patients,which is worthy of popularization in clinic.
2018, 43(1): 110-113.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.033
Abstract:
Objective:To explore the effects of the hospital-community linkage nursing management mode on the rehabilitation and quality of life in patients with stroke.Methods:One hundred and twenty stroke patients were randomly divided into the observation group and control group(60 cases each group).The control group was taught with the routine health mode,and the observation group were taught with hospital-community linkage nursing management mode based on the control group for 6 months.The functional status,activities of daily living,neurological deficit before intervention,after 3 and 6 months of intervention,and the quality of life before intervention and after 6 months of intervention between two groups were compared.Results:After 3 and 6 months of intervention,the scores of functional status and activities of daily living in observation group were significantly higher than those in control group(P<0.01),while the score of NIHSS in observation group was significantly lower than that in control group(P<0.01).The scores of functional status and activities of daily living in two groups after intervention were significantly higher than those before intervention,and the score of NIHSS in two groups after intervention was significantly lower than that before intervention(P<0.05 to P<0.01).After 6 months of intervention,the total scores of physical life,physical function,mental function,social function and social quality in observation group were significantly higher than those in control group(P<0.01).Conclusions:The hospital-community linkage nursing management mode can effective promote the recovery of limb function,reduce neurological deficits,and improve the quality of life of patients with stroke.
Objective:To explore the effects of the hospital-community linkage nursing management mode on the rehabilitation and quality of life in patients with stroke.Methods:One hundred and twenty stroke patients were randomly divided into the observation group and control group(60 cases each group).The control group was taught with the routine health mode,and the observation group were taught with hospital-community linkage nursing management mode based on the control group for 6 months.The functional status,activities of daily living,neurological deficit before intervention,after 3 and 6 months of intervention,and the quality of life before intervention and after 6 months of intervention between two groups were compared.Results:After 3 and 6 months of intervention,the scores of functional status and activities of daily living in observation group were significantly higher than those in control group(P<0.01),while the score of NIHSS in observation group was significantly lower than that in control group(P<0.01).The scores of functional status and activities of daily living in two groups after intervention were significantly higher than those before intervention,and the score of NIHSS in two groups after intervention was significantly lower than that before intervention(P<0.05 to P<0.01).After 6 months of intervention,the total scores of physical life,physical function,mental function,social function and social quality in observation group were significantly higher than those in control group(P<0.01).Conclusions:The hospital-community linkage nursing management mode can effective promote the recovery of limb function,reduce neurological deficits,and improve the quality of life of patients with stroke.
2018, 43(1): 114-116,120.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.034
Abstract:
Objective:To explore the application value of knowledge-attitude-belief training mode in the training of junior nurses in pediatrics.Methods:One hundred and twenty-two junior nurses were randomly divided into the observation group and control group.The observation group and control group were trained using knowledge-attitude-belief training mode and traditional core system training mode for 1 month,respectively.All nurses were followed up for 6 months,and the skill between two groups before and after training was compared.Results:After training,the scores of the professional sentiment,cognitive skill,interpersonal relationship,self-management,organization management,software skill,theoretical knowledge,operational skill and comprehensive quality in observation group were significantly higher than those in control group(P<0.01).There was no statistical significance in the self-satisfaction rate of nurses and satisfaction rate of family members between two groups before and after nurses training(P>0.05).Conclusions:The application of knowledge-attitude-belief training mode in the training of junior nurses in pediatrics can improve the comprehensive quality of nurses,better adapt to the high risk and workload of pediatrics,and improve the nursing quality.
Objective:To explore the application value of knowledge-attitude-belief training mode in the training of junior nurses in pediatrics.Methods:One hundred and twenty-two junior nurses were randomly divided into the observation group and control group.The observation group and control group were trained using knowledge-attitude-belief training mode and traditional core system training mode for 1 month,respectively.All nurses were followed up for 6 months,and the skill between two groups before and after training was compared.Results:After training,the scores of the professional sentiment,cognitive skill,interpersonal relationship,self-management,organization management,software skill,theoretical knowledge,operational skill and comprehensive quality in observation group were significantly higher than those in control group(P<0.01).There was no statistical significance in the self-satisfaction rate of nurses and satisfaction rate of family members between two groups before and after nurses training(P>0.05).Conclusions:The application of knowledge-attitude-belief training mode in the training of junior nurses in pediatrics can improve the comprehensive quality of nurses,better adapt to the high risk and workload of pediatrics,and improve the nursing quality.
2018, 43(1): 117-120.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.035
Abstract:
Objective:To investigate the effects of family follow-up service mode on the postoperative rehabilitation and quality of life in patients with craniocerebral trauma.Methods:One hundred and twenty patients with craniocerebral trauma were divided into the observation group(n=60) and control group(n=60) according to the random number table method.The control group was treated with conventional discharge guidance,and the observation group was treated with family follow-up service mode for 6 months.The mental status,activities of daily living and quality of life in two groups at 1,3 and 6 months of intervention were evaluated using the mental health scale(MMSE),Fugl-Meyer score and quality of life scale integrated assessment questionnaire(GQOLI-74),respectively.Results:The differences of the MMSE score,Fugl-Meyer score and GQOLI-74 score between two groups before intervention were not statistically significant(P>0.05).The MMSE score,Fugl-Meyer score and GQOLI-74 score in observation group were higher than those in control group at 1,3 and 6 months of intervention(P<0.01).The MMSE score,Fugl-Meyer score and GQOLI-74 score in two groups at 1,3 and 6 months of intervention were significantly higher than those before intervention(P<0.01).The scores of MMSE,Fugl-Meyer and GQOLI-74 in two groups at 3 and 6 months were significantly higher than those at 1 month of intervention(P<0.01),and the scores of MMSE,Fugl-Meyer and GQOLI-74 in two groups at 6 months of intervention were significnatly higher than those at 3 months of intervention(P<0.01).Conclusions:The family follow-up service model can effectively improve the mental status,activities of daily living and quality of life in patients with craniocerebral trauma.
Objective:To investigate the effects of family follow-up service mode on the postoperative rehabilitation and quality of life in patients with craniocerebral trauma.Methods:One hundred and twenty patients with craniocerebral trauma were divided into the observation group(n=60) and control group(n=60) according to the random number table method.The control group was treated with conventional discharge guidance,and the observation group was treated with family follow-up service mode for 6 months.The mental status,activities of daily living and quality of life in two groups at 1,3 and 6 months of intervention were evaluated using the mental health scale(MMSE),Fugl-Meyer score and quality of life scale integrated assessment questionnaire(GQOLI-74),respectively.Results:The differences of the MMSE score,Fugl-Meyer score and GQOLI-74 score between two groups before intervention were not statistically significant(P>0.05).The MMSE score,Fugl-Meyer score and GQOLI-74 score in observation group were higher than those in control group at 1,3 and 6 months of intervention(P<0.01).The MMSE score,Fugl-Meyer score and GQOLI-74 score in two groups at 1,3 and 6 months of intervention were significantly higher than those before intervention(P<0.01).The scores of MMSE,Fugl-Meyer and GQOLI-74 in two groups at 3 and 6 months were significantly higher than those at 1 month of intervention(P<0.01),and the scores of MMSE,Fugl-Meyer and GQOLI-74 in two groups at 6 months of intervention were significnatly higher than those at 3 months of intervention(P<0.01).Conclusions:The family follow-up service model can effectively improve the mental status,activities of daily living and quality of life in patients with craniocerebral trauma.
2018, 43(1): 121-124.
doi: 10.13898/j.cnki.issn.1000-2200.2018.01.036
Abstract:
Objective:To investigate the effects of strengthening social and family support on the psychological state and activity of daily living in patients with depression after cerebral infarction.Methods:A total of 118 patients with depression after cerebral infarction were randomly divided into the observation group and control group according to the random number table method(59 cases each group).The control group were implemented using routine nursing,and the observation group were implemented with strengthening social and family support intervention.The psychological state,neurological function,activity of daily living and clinical efficacy between two groups were compared.Results:The effective rate in observation group(89.83%) was higher than that in control group(74.58%)(P<0.05).After intervention,the scores of SAS,SDS and NIHSS significantly decreased in two groups(P<0.01),and the decreasing degree of which in observation group was more than that in control group(P<0.01).After intervention,the score of Barthel index significantly increased in two groups(P<0.01),and the increasing degree of which in observation group was more than that in control group(P<0.01).Conclusions:Strengthening social and family support can improve the adverse psychological state,reduce the neurological deficit and enhance the activity of daily living in patients with depression after cerebral infarction.
Objective:To investigate the effects of strengthening social and family support on the psychological state and activity of daily living in patients with depression after cerebral infarction.Methods:A total of 118 patients with depression after cerebral infarction were randomly divided into the observation group and control group according to the random number table method(59 cases each group).The control group were implemented using routine nursing,and the observation group were implemented with strengthening social and family support intervention.The psychological state,neurological function,activity of daily living and clinical efficacy between two groups were compared.Results:The effective rate in observation group(89.83%) was higher than that in control group(74.58%)(P<0.05).After intervention,the scores of SAS,SDS and NIHSS significantly decreased in two groups(P<0.01),and the decreasing degree of which in observation group was more than that in control group(P<0.01).After intervention,the score of Barthel index significantly increased in two groups(P<0.01),and the increasing degree of which in observation group was more than that in control group(P<0.01).Conclusions:Strengthening social and family support can improve the adverse psychological state,reduce the neurological deficit and enhance the activity of daily living in patients with depression after cerebral infarction.
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