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2018 Vol. 43, No. 3
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2018, 43(3): 281-283,287.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.001
Abstract:
Objective:To explore the expression of metastasis-associated lung adenocarcinoma transcript 1(MALAT1) long non-coding RNA in pancreatic cancer cells,and its effect on the metastasis of PANC-1.Methods:The expression levels of MALAT1 in 4 pancreatic cancer cell lines were analyzed by real-time PCR.The level of MALAT1 in PANC-1 was down-regulated by small interfering RNA.The abilities of attachment detachment,migration and invasion of PANC-1 were measured using the attachment assay,detachment assay,Transwell migration and invasion assay,respectively.The protein levels of Vimentin,MMP-2 and MMP-9 in PANC-1 were detected by Western blotting.Results:The expression levels of MALAT1 in 4 pancreatic cancer cell lines were different,and which was the highest in PANC-1.After down-regulating the level of MALAT1 in PANC-1,the protein levels of Vimentin,MMP-2 and MMP-9 significantly decreased(P<0.01),and the abilities of attachment detachment,migration and invasion of PANC-1 significantly weakened(P<0.01).Conclusions:Down-regulating the expression of MALAT1 can decrease the levels of Vimentin,MMP-2 and MMP-9,which can attenuate the capacity of PANC-1 metastasis.
Objective:To explore the expression of metastasis-associated lung adenocarcinoma transcript 1(MALAT1) long non-coding RNA in pancreatic cancer cells,and its effect on the metastasis of PANC-1.Methods:The expression levels of MALAT1 in 4 pancreatic cancer cell lines were analyzed by real-time PCR.The level of MALAT1 in PANC-1 was down-regulated by small interfering RNA.The abilities of attachment detachment,migration and invasion of PANC-1 were measured using the attachment assay,detachment assay,Transwell migration and invasion assay,respectively.The protein levels of Vimentin,MMP-2 and MMP-9 in PANC-1 were detected by Western blotting.Results:The expression levels of MALAT1 in 4 pancreatic cancer cell lines were different,and which was the highest in PANC-1.After down-regulating the level of MALAT1 in PANC-1,the protein levels of Vimentin,MMP-2 and MMP-9 significantly decreased(P<0.01),and the abilities of attachment detachment,migration and invasion of PANC-1 significantly weakened(P<0.01).Conclusions:Down-regulating the expression of MALAT1 can decrease the levels of Vimentin,MMP-2 and MMP-9,which can attenuate the capacity of PANC-1 metastasis.
2018, 43(3): 284-287.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.002
Abstract:
Objective:To evaluate the protective effects of erythropoietin(EPO) on the lung of rats after cardiopulmonary resuscitation(CPR).Methods:The rats were randomly divided into the sham group,CPR group and EPO group.The levels of MDA,SOD and GSH-Px in lung were detected using ELISA.Results:At the time of restoration of spontaneous circulation,the levels of CaO2 in CPR group and EPO group were lower than that in sham group(P<0.05),and with the lengthening of restoration time,the level of which gradually returned to normal.After 3 h,6 h and 12 h of CPR,the levels of MDA in CPR group and EPO group were significantly higher than that in sham group(P<0.01),the levels of MDA in CPR group after 6 h and 12 h of CPR were significantly higher than that after 3 h of CPR(P<0.01),and the levels of MDA in EPO group after 6 h and 12 h of CPR were lower than that in CPR group(P<0.05 and P<0.01).Compared with the sham group,the levels of SOD and GSH-Px in CPR group and EPO group decreased after 3 h,6 h and 12 h of CPR(P<0.05 to P<0.01),the levels of SOD and GSH-Px in CPR group after 6 h of CPR were significantly lower than those after 3 h of CPR(P<0.01),and the levels of SOD and GSH-Px in CPR group after 12 h of CPR were significantly higher than those after 6 h of CPR(P<0.01).The levels of SOD and GSH-Px in EPO group after 3 h,6 h and 12 h of CPR were significantly lower than those in CPR group(P<0.01).Before treatment with EPO,the content of MDA was negatively correlated with SOD(P<0.05) and GSH-Px(P<0.01) in rats.After treatment with EPO,the content of MDA was negatively correlated with GSH-Px(P<0.05),but uncorrelated with SOD in rats(P>0.05).Conclusions:EPO can reduce the oxidative stress and injury of lung,and promote the recovery of lung function after CPR.
Objective:To evaluate the protective effects of erythropoietin(EPO) on the lung of rats after cardiopulmonary resuscitation(CPR).Methods:The rats were randomly divided into the sham group,CPR group and EPO group.The levels of MDA,SOD and GSH-Px in lung were detected using ELISA.Results:At the time of restoration of spontaneous circulation,the levels of CaO2 in CPR group and EPO group were lower than that in sham group(P<0.05),and with the lengthening of restoration time,the level of which gradually returned to normal.After 3 h,6 h and 12 h of CPR,the levels of MDA in CPR group and EPO group were significantly higher than that in sham group(P<0.01),the levels of MDA in CPR group after 6 h and 12 h of CPR were significantly higher than that after 3 h of CPR(P<0.01),and the levels of MDA in EPO group after 6 h and 12 h of CPR were lower than that in CPR group(P<0.05 and P<0.01).Compared with the sham group,the levels of SOD and GSH-Px in CPR group and EPO group decreased after 3 h,6 h and 12 h of CPR(P<0.05 to P<0.01),the levels of SOD and GSH-Px in CPR group after 6 h of CPR were significantly lower than those after 3 h of CPR(P<0.01),and the levels of SOD and GSH-Px in CPR group after 12 h of CPR were significantly higher than those after 6 h of CPR(P<0.01).The levels of SOD and GSH-Px in EPO group after 3 h,6 h and 12 h of CPR were significantly lower than those in CPR group(P<0.01).Before treatment with EPO,the content of MDA was negatively correlated with SOD(P<0.05) and GSH-Px(P<0.01) in rats.After treatment with EPO,the content of MDA was negatively correlated with GSH-Px(P<0.05),but uncorrelated with SOD in rats(P>0.05).Conclusions:EPO can reduce the oxidative stress and injury of lung,and promote the recovery of lung function after CPR.
2018, 43(3): 288-291,295.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.003
Abstract:
Objective:To investigate the correlation between bacterial group behavior and expressions of quorum-sensing system(QS) genes in pan drug resistance Pseudomonas aeruginosa(PA).Methods:The bacterial group behaviors(including elastase,pyocyanin and biofilm) and expression of QS genes were measured.The correlation between PA group behavior and QS gene expression in pan drug resistant PA group and fully sensitive PA group was analyzed.Results:Five cases of pan drug resistance PA and 5 cases of all sensitive PA were collected.In pan drug resistance PA group,the elastase and pyocyanin were positive correlation with expression of LasI(P<0.05),and the biofilm was positively associated with RhlR(P<0.05).There was not correlation between bacterial group behavior and QS gene in all sensitive PA group(P>0.05).The differences of the Rhll level on the first day and LasI and LasR levels on the fourteenth day between two groups were statistically significant(P<0.05).The differences of the elastase,biofilm,and LasI and LasR levels between before and after treatment were statistically significant(P<0.05).The amino acid mutation in 1 strain PA was found.Conclusions:The pan drug resistance PA group behavior is correlation with QS gene.The elastase and biofilm,and more expression levels of LasI and LasR hint that the QS gene plays a key role in the drug resistance mechanism of PA.
Objective:To investigate the correlation between bacterial group behavior and expressions of quorum-sensing system(QS) genes in pan drug resistance Pseudomonas aeruginosa(PA).Methods:The bacterial group behaviors(including elastase,pyocyanin and biofilm) and expression of QS genes were measured.The correlation between PA group behavior and QS gene expression in pan drug resistant PA group and fully sensitive PA group was analyzed.Results:Five cases of pan drug resistance PA and 5 cases of all sensitive PA were collected.In pan drug resistance PA group,the elastase and pyocyanin were positive correlation with expression of LasI(P<0.05),and the biofilm was positively associated with RhlR(P<0.05).There was not correlation between bacterial group behavior and QS gene in all sensitive PA group(P>0.05).The differences of the Rhll level on the first day and LasI and LasR levels on the fourteenth day between two groups were statistically significant(P<0.05).The differences of the elastase,biofilm,and LasI and LasR levels between before and after treatment were statistically significant(P<0.05).The amino acid mutation in 1 strain PA was found.Conclusions:The pan drug resistance PA group behavior is correlation with QS gene.The elastase and biofilm,and more expression levels of LasI and LasR hint that the QS gene plays a key role in the drug resistance mechanism of PA.
2018, 43(3): 292-295.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.004
Abstract:
Objective:To observe the effects of medium and long chain triglyceride emulsion of propofol in the anesthesia of infant,and evaluate its effects on hemodynamics,recovery period quality and liver function.Methods:Fifty infants with stage ASAⅠto Ⅱ,1 month to 3 years old,were randomly divided into the medium and long chain triglyceride emulsion of propofol group(group M) and sevoflurane group(group S) (25 cases each group).The group M and S were anesthesia induced and maintained using long chain triglyceride emulsion of propofol and sevoflurane,respectively.The MAP and HR in two groups were oobserved before anesthesia induction(T0) tracheal intubation(T1),at the end of operation(T2) and tracheal extubation(T3).The times from stopping drug to recover pontaneous breath and from restoring breath to extubation,and restlessness,nausea and vomiting during the awakening period were recorded.The levels of ALT and AST in two groups before operation,after operation and after 24 h of operation were detected.Results:Compared with T0,the HR and MAP in two group significantly decreased at T1(P<0.05).The time from restoring breath to extubation in group M was significnatly shorter than that in group S(P<0.01).The indcience rates of restlessness,nausea and vomiting in group M were significnatly less than those in group S(P<0.05 to P<0.01).The differences of the levels of ALT and AST in two groups between T2 and after 24 h of operation were not statistically significant(P>0.05).Conclusions:Medium and long chain triglyceride emulsion propofol can be safely used in infants,which is low incidences rate of restlessness,nausea and vomiting during recovery period.Medium and long chain triglyceride emulsion propofol does not affect the liver function in short time surgery.
Objective:To observe the effects of medium and long chain triglyceride emulsion of propofol in the anesthesia of infant,and evaluate its effects on hemodynamics,recovery period quality and liver function.Methods:Fifty infants with stage ASAⅠto Ⅱ,1 month to 3 years old,were randomly divided into the medium and long chain triglyceride emulsion of propofol group(group M) and sevoflurane group(group S) (25 cases each group).The group M and S were anesthesia induced and maintained using long chain triglyceride emulsion of propofol and sevoflurane,respectively.The MAP and HR in two groups were oobserved before anesthesia induction(T0) tracheal intubation(T1),at the end of operation(T2) and tracheal extubation(T3).The times from stopping drug to recover pontaneous breath and from restoring breath to extubation,and restlessness,nausea and vomiting during the awakening period were recorded.The levels of ALT and AST in two groups before operation,after operation and after 24 h of operation were detected.Results:Compared with T0,the HR and MAP in two group significantly decreased at T1(P<0.05).The time from restoring breath to extubation in group M was significnatly shorter than that in group S(P<0.01).The indcience rates of restlessness,nausea and vomiting in group M were significnatly less than those in group S(P<0.05 to P<0.01).The differences of the levels of ALT and AST in two groups between T2 and after 24 h of operation were not statistically significant(P>0.05).Conclusions:Medium and long chain triglyceride emulsion propofol can be safely used in infants,which is low incidences rate of restlessness,nausea and vomiting during recovery period.Medium and long chain triglyceride emulsion propofol does not affect the liver function in short time surgery.
2018, 43(3): 296-298,303.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.005
Abstract:
Objective:To observe the effects of horticultural therapy combined with rehabilitation intervention in stroke patients with unilateral spatial neglect(USN).Methods:Forty-six USN patients were randomly divided into the observation group and control group(33 cases each group).The control group were treated with routine rehabilitation,and the observation group were treated with horticultural therapy combined with rehabilitation.The mentality,exercise function and ability of daily living(ADL) in two groups before and after treatment were assessed using the Hamilton Depression Scale(HAMD),Fugl-Meyer Assessment(FMA),and Modified Barthel Index(MBI) and Functional Independence Measure(FIM),respectively.Results:The differences of the scores of HAMD,FMA,and MBI and FIM between two groups before treatment were not statistically significant(P>0.05).After treatment,all items scores in two groups were significantly improved compared before treatment(P<0.01),and the improvement degree of which in observation group was significantly better than that in control group(P<0.01).Conclusions:During the rehabilitation training of USN,the horticultural therapy can improve the USN status and quality of life patient's,and which has important significance in the rehabilitation and prognosis of patients with stroke.
Objective:To observe the effects of horticultural therapy combined with rehabilitation intervention in stroke patients with unilateral spatial neglect(USN).Methods:Forty-six USN patients were randomly divided into the observation group and control group(33 cases each group).The control group were treated with routine rehabilitation,and the observation group were treated with horticultural therapy combined with rehabilitation.The mentality,exercise function and ability of daily living(ADL) in two groups before and after treatment were assessed using the Hamilton Depression Scale(HAMD),Fugl-Meyer Assessment(FMA),and Modified Barthel Index(MBI) and Functional Independence Measure(FIM),respectively.Results:The differences of the scores of HAMD,FMA,and MBI and FIM between two groups before treatment were not statistically significant(P>0.05).After treatment,all items scores in two groups were significantly improved compared before treatment(P<0.01),and the improvement degree of which in observation group was significantly better than that in control group(P<0.01).Conclusions:During the rehabilitation training of USN,the horticultural therapy can improve the USN status and quality of life patient's,and which has important significance in the rehabilitation and prognosis of patients with stroke.
2018, 43(3): 299-303.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.006
Abstract:
Objective:To observe the efficacy and safety of dexmedetomidine(Dex) in preventing and treating remifentanil-induced hyperalgesia(RIH).Methods:Eighty patients(stage ASA Ⅰ to Ⅱ) scheduled by radical resection of esophageal carcinoma were randomly divided into the low dose of Dex group(group LD),medium dose of Dex group(group MD),high dose of Dex group(group HD) and control group(group C) (20 cases each group).Before the induction of anaesthesia,group LD,MD and HD were treated with 0.25 μg/kg,0.50 μg/kg and 1.00 μg/kg of Dex by intravenous infusion for 10 min,then with 0.25 μg·kg-1·h-1,0.50 μg·kg-1·h-1 and 1.0 μg·kg-1·h-1 of Dex till 30 min before the end of the operation,respectively.The C group were treated with the same volume 0.9% sodium chloride injection.The score of improved OAA/S after extubation,and the scores of VAS 10 min,30 min,1 h,2 h,6 h,12 h and 24 h after extubation in four groups were recorded.The total drug mount in PCA and incidence rate of postoperative adverse reactions in four groups 24 h after operation were recorded.Results:The scores of VAS in group LD,MD and HD after extubation were significantly lower than that in group C(P<0.01),which was dose-dependent.The total drug mount in PCA and incidence rates of postoperative adverse reactions in group LD,MD and HD after 24 h of operation were significantly less than those in group C(P<0.01).Conclusions:Intraoperative infusion of medium dose of Dex can safely and effectively relieve postoperative pain,attenuate high-dose remifentanil-induced hyperalgesia,reduce the complication and improve the satisfaction of patients.
Objective:To observe the efficacy and safety of dexmedetomidine(Dex) in preventing and treating remifentanil-induced hyperalgesia(RIH).Methods:Eighty patients(stage ASA Ⅰ to Ⅱ) scheduled by radical resection of esophageal carcinoma were randomly divided into the low dose of Dex group(group LD),medium dose of Dex group(group MD),high dose of Dex group(group HD) and control group(group C) (20 cases each group).Before the induction of anaesthesia,group LD,MD and HD were treated with 0.25 μg/kg,0.50 μg/kg and 1.00 μg/kg of Dex by intravenous infusion for 10 min,then with 0.25 μg·kg-1·h-1,0.50 μg·kg-1·h-1 and 1.0 μg·kg-1·h-1 of Dex till 30 min before the end of the operation,respectively.The C group were treated with the same volume 0.9% sodium chloride injection.The score of improved OAA/S after extubation,and the scores of VAS 10 min,30 min,1 h,2 h,6 h,12 h and 24 h after extubation in four groups were recorded.The total drug mount in PCA and incidence rate of postoperative adverse reactions in four groups 24 h after operation were recorded.Results:The scores of VAS in group LD,MD and HD after extubation were significantly lower than that in group C(P<0.01),which was dose-dependent.The total drug mount in PCA and incidence rates of postoperative adverse reactions in group LD,MD and HD after 24 h of operation were significantly less than those in group C(P<0.01).Conclusions:Intraoperative infusion of medium dose of Dex can safely and effectively relieve postoperative pain,attenuate high-dose remifentanil-induced hyperalgesia,reduce the complication and improve the satisfaction of patients.
2018, 43(3): 304-306.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.007
Abstract:
Objective:To investigate the mycoplasma infection status and drug sensitive situation in Lianyungang so as to provide the theoretical basis for clinical rational treatment.Methods:The clinical data of the culture and drug sensitivity of mycoplasma in 2 726 cases suspected by urogenital infection were retrospectively analyzed.Results:Among 2 726 patients,the mycoplasma infection in 1 226 cases(44.97%) were identified,which included the 995 cases(81.16%) of the positive UU infection,30 cases(2.45%) of positive MH infection and 201 cases(16.39%) of mixed infection.The mycoplasma infection rate in females(54.54%) was higher than that in males(26.48%) (P<0.01).The patients with positive UU infection were mostly sensitive to the minocycline,doxycycline and clarithromycin,and the patients with positive Mh were mostly sensitive to clarithromycin,minocycline and doxycycline,and the patients with mixed UU with MH were mostly sensitive to the minocycline and doxycycline.Conclusions:Mycoplasma is resistant to part of the antimicrobial drug.UU is the major pathogen of mycoplasma infection,followed by mixed UU with MH in Lianyungang,and the minocycline and doxycycline may be the first line drug in treating mycoplasma infection.Drug sensitivity test should be carried out in clinical practice to reduce empiric drug use.
Objective:To investigate the mycoplasma infection status and drug sensitive situation in Lianyungang so as to provide the theoretical basis for clinical rational treatment.Methods:The clinical data of the culture and drug sensitivity of mycoplasma in 2 726 cases suspected by urogenital infection were retrospectively analyzed.Results:Among 2 726 patients,the mycoplasma infection in 1 226 cases(44.97%) were identified,which included the 995 cases(81.16%) of the positive UU infection,30 cases(2.45%) of positive MH infection and 201 cases(16.39%) of mixed infection.The mycoplasma infection rate in females(54.54%) was higher than that in males(26.48%) (P<0.01).The patients with positive UU infection were mostly sensitive to the minocycline,doxycycline and clarithromycin,and the patients with positive Mh were mostly sensitive to clarithromycin,minocycline and doxycycline,and the patients with mixed UU with MH were mostly sensitive to the minocycline and doxycycline.Conclusions:Mycoplasma is resistant to part of the antimicrobial drug.UU is the major pathogen of mycoplasma infection,followed by mixed UU with MH in Lianyungang,and the minocycline and doxycycline may be the first line drug in treating mycoplasma infection.Drug sensitivity test should be carried out in clinical practice to reduce empiric drug use.
2018, 43(3): 307-309.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.008
Abstract:
Objective:To study the effects of the sequential therapy of traditional Chinese combined with western medicine in the eradication of Helicobacter pylori(HP) for provoding the reference in treating chronic gastritis complicated with HP infection.Methods:Sixty patients with chronic gastritis complicated with HP infection were randomly divided into the group A,group B and control group(20 cases each group).The control group were treated with the sequential therapy of western medicine for 10 days,the group A were treated with the sequential therapy of western medicine for 10 days,then with traditional Chinese for 4 weeks,and the group B were treated with the sequential therapy of western medicine for 10 days,then with traditional Chinese for 2 weeks.The eradication rates of HP in three groups were observed,which was evaluated using symptom score scale.Results:The symptom scores in three groups after treatment were significnatly lower than those before treatment(P<0.01).The differences of the eradication rates of HP between three groups were not statistically significant after treatment(P>0.05).The incidence rates of adverse reactions in group A and group B were lower than that in control group(P<0.05).Conclusions:The sequential therapy of traditional Chinese combined with western medicine in the treatment of chronic gastritis complicated with HP infection can eradicate the HP and relieve symptoms,and the incidence rate of adverse reaction of which is lower than that of single sequential therapy of western medicine.
Objective:To study the effects of the sequential therapy of traditional Chinese combined with western medicine in the eradication of Helicobacter pylori(HP) for provoding the reference in treating chronic gastritis complicated with HP infection.Methods:Sixty patients with chronic gastritis complicated with HP infection were randomly divided into the group A,group B and control group(20 cases each group).The control group were treated with the sequential therapy of western medicine for 10 days,the group A were treated with the sequential therapy of western medicine for 10 days,then with traditional Chinese for 4 weeks,and the group B were treated with the sequential therapy of western medicine for 10 days,then with traditional Chinese for 2 weeks.The eradication rates of HP in three groups were observed,which was evaluated using symptom score scale.Results:The symptom scores in three groups after treatment were significnatly lower than those before treatment(P<0.01).The differences of the eradication rates of HP between three groups were not statistically significant after treatment(P>0.05).The incidence rates of adverse reactions in group A and group B were lower than that in control group(P<0.05).Conclusions:The sequential therapy of traditional Chinese combined with western medicine in the treatment of chronic gastritis complicated with HP infection can eradicate the HP and relieve symptoms,and the incidence rate of adverse reaction of which is lower than that of single sequential therapy of western medicine.
2018, 43(3): 310-312,315.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.009
Abstract:
Objective:To investigate the clinical efficacy and safety of piperazine ferulate combined with pancreatic kininogenase in the treatment of diabetic nephropathy.Methods:One hundred and eighty diabetic nephropathy patients were divided into the observation group and control group according to the random envelope method(90 cases each group).The control group and observation group were treated with piperazine ferulate,and piperazine ferulate combined with pancreatic kininogenase for 4 weeks,respectively.Results:The total effective rate in observation group was significantly higher than that in control group(P<0.01).After treatment,the levels of UAER and Scr in two groups were significantly lower than those before treatment(P<0.01),and which in observation group was significantly lower than that in control group(P<0.01).After treatment,the serum levels of CysC and β2MG in observation group[(1.11±0.42) mg/L &(2.82±0.24) mg/L)] were significantly lower those in control group[(2.12±0.64) mg/L &(3.56±0.38) mg/L](P<0.01),respectively(P<0.01),and the serum levels of CysC and β2MG in two groups were significantly lower than those before treatment(P<0.01).There were no obvious adverse reactions in two groups.Conclusions:Piperazine ferulate combined with pancreatic kininogenase in the treatment of diabetic nephropathy is safe,which can improve the curative effect,and promote the urinary protein excretion and renal function stabilization.
Objective:To investigate the clinical efficacy and safety of piperazine ferulate combined with pancreatic kininogenase in the treatment of diabetic nephropathy.Methods:One hundred and eighty diabetic nephropathy patients were divided into the observation group and control group according to the random envelope method(90 cases each group).The control group and observation group were treated with piperazine ferulate,and piperazine ferulate combined with pancreatic kininogenase for 4 weeks,respectively.Results:The total effective rate in observation group was significantly higher than that in control group(P<0.01).After treatment,the levels of UAER and Scr in two groups were significantly lower than those before treatment(P<0.01),and which in observation group was significantly lower than that in control group(P<0.01).After treatment,the serum levels of CysC and β2MG in observation group[(1.11±0.42) mg/L &(2.82±0.24) mg/L)] were significantly lower those in control group[(2.12±0.64) mg/L &(3.56±0.38) mg/L](P<0.01),respectively(P<0.01),and the serum levels of CysC and β2MG in two groups were significantly lower than those before treatment(P<0.01).There were no obvious adverse reactions in two groups.Conclusions:Piperazine ferulate combined with pancreatic kininogenase in the treatment of diabetic nephropathy is safe,which can improve the curative effect,and promote the urinary protein excretion and renal function stabilization.
2018, 43(3): 313-315.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.010
Abstract:
Objective:To investigate the clinical curative effects of butylphthalide soft capsule on cerebral small vessel patients disease complicated with cognitive impairment,and its influence on blood perfusion.Methods:One hundred and twenty patients with cerebral small vascular disease were randomly divided into the observation group and control group(60 cases each group).The control group was conventionally treated with reducing pressure,adjusting fat and improving circulation,and the observation group was additionally treated with butylphthalide based on control group for 1 month.The simple mental state examination(MMSE) and montreal scale(MOCA) scores in two groups before and after treatment were recorded.Two groups were examined using 64-slice spiral CT perfusion imaging,to calculate perfusion parameters.Results:Before treatment,the differences of MMSE and MOCA scores between two groups were not statistically significant(P>0.05),the MMSE and MOCA scores in two groups after treatment significantly increased,and the increasing degree of which in observation group was more obvious.Before treatment,the differences of blood flow velocity,cerebral blood volume and mean transition time between two groups were not statistically significant(P>0.05),the blood flow velocity,cerebral blood volume and mean transition time in two groups after treatment significantly improved(P<0.05 to P<0.01),and the improving degree of which in observation group was more obvious(P<0.01).Conclusions:Butylphthalide soft capsule can improve the cognitive function and increase the blood flow of lesions,which is safe and effective,and worthy of clinical promotion.
Objective:To investigate the clinical curative effects of butylphthalide soft capsule on cerebral small vessel patients disease complicated with cognitive impairment,and its influence on blood perfusion.Methods:One hundred and twenty patients with cerebral small vascular disease were randomly divided into the observation group and control group(60 cases each group).The control group was conventionally treated with reducing pressure,adjusting fat and improving circulation,and the observation group was additionally treated with butylphthalide based on control group for 1 month.The simple mental state examination(MMSE) and montreal scale(MOCA) scores in two groups before and after treatment were recorded.Two groups were examined using 64-slice spiral CT perfusion imaging,to calculate perfusion parameters.Results:Before treatment,the differences of MMSE and MOCA scores between two groups were not statistically significant(P>0.05),the MMSE and MOCA scores in two groups after treatment significantly increased,and the increasing degree of which in observation group was more obvious.Before treatment,the differences of blood flow velocity,cerebral blood volume and mean transition time between two groups were not statistically significant(P>0.05),the blood flow velocity,cerebral blood volume and mean transition time in two groups after treatment significantly improved(P<0.05 to P<0.01),and the improving degree of which in observation group was more obvious(P<0.01).Conclusions:Butylphthalide soft capsule can improve the cognitive function and increase the blood flow of lesions,which is safe and effective,and worthy of clinical promotion.
2018, 43(3): 316-318,323.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.011
Abstract:
Objective:To study the correlation between neck circumference(NC) and insulin resistance(IR) in different genders patients with type 2 diabetes mellitus(T2DM).Methods:A total of 165 diabetic patients were divided into the male group and female group.The body mass index(BMI),NC,waist circunference(WC),waist-hip ratio(WHR),hip circumference(HC) and blood biochemical indicators in two groups were measured,and which was analyzed.The correlations between NC and each parameter,and between NC,WC and HOMA-IR were analyzed using spearman linear correlation analysis.Logistic regression was used to analyze that whether the NC was or not one of risk factor of T2DM.Results:In male group,the age was not correlation with NC(P>0.05),the hight-density lipoprotein(HDL) was negatively correlated with NC(P<0.01),and other indicators were positively correlated with NC(P<0.05 to P<0.01).In female group,the age and hip circumference were not correlation with NC(P<0.05),the HDL was negatively correlated with NC(P<0.01),other indicators were positively correlated with NC(P<0.05 to P<0.01),and especially the NC was strongly positive correlation with BMI and WC(P<0.05).After adjusting age and gender,the NC,WC and TG were the risk factors of T2DM,while the HDL was the protective factor of T2DM.Conclusions:NC is positively related to IR,a risk factor of T2DM,and which has more advantages than other parameters(such as BMI and WC).NC can be used as a better indicator in evaluating T2DM,which has great clinical significance.
Objective:To study the correlation between neck circumference(NC) and insulin resistance(IR) in different genders patients with type 2 diabetes mellitus(T2DM).Methods:A total of 165 diabetic patients were divided into the male group and female group.The body mass index(BMI),NC,waist circunference(WC),waist-hip ratio(WHR),hip circumference(HC) and blood biochemical indicators in two groups were measured,and which was analyzed.The correlations between NC and each parameter,and between NC,WC and HOMA-IR were analyzed using spearman linear correlation analysis.Logistic regression was used to analyze that whether the NC was or not one of risk factor of T2DM.Results:In male group,the age was not correlation with NC(P>0.05),the hight-density lipoprotein(HDL) was negatively correlated with NC(P<0.01),and other indicators were positively correlated with NC(P<0.05 to P<0.01).In female group,the age and hip circumference were not correlation with NC(P<0.05),the HDL was negatively correlated with NC(P<0.01),other indicators were positively correlated with NC(P<0.05 to P<0.01),and especially the NC was strongly positive correlation with BMI and WC(P<0.05).After adjusting age and gender,the NC,WC and TG were the risk factors of T2DM,while the HDL was the protective factor of T2DM.Conclusions:NC is positively related to IR,a risk factor of T2DM,and which has more advantages than other parameters(such as BMI and WC).NC can be used as a better indicator in evaluating T2DM,which has great clinical significance.
2018, 43(3): 319-323.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.012
Abstract:
Objective:To investigate the clinical factors of cognitive impairment in elderly patients with lacunar infarction(LI),and provide reference in improving the cognitive function of patients.Methods:One hundred and seventeen elderly patients with LI(LI group) were subdivided into the bilateral group,left group and right group according to the lesion location,and 100 healthy people were set as the control group.The score of Montreal cognitive assessment scale(MoCA) between two groups was compared.The influencing factors of cognitive function in elderly patients with LI were analyzed using the single factor analysis and multi factor logistic regression analysis.Results:Among 117 cases,the total score of MoCA was(24.92±2.96),the cognitive dysfunction in 64 cases(54.70%) were found.The delayed recall,attention,language,visual space/executive function and MoCA score in LI group were lower than those in control group(P<0.05 to P<0.01).The delayed recall,language,visual space/executive function and MoCA score in right group were higher than those in bilateral group and left group(P<0.05 to P<0.01),and which in left group was higher than that in bilateral group(P<0.05 to P<0.01).The attention score in right group was higher than that in bilateral group(P<0.01).The analysis result of influencing factors showed that the lesion location,hypertension,diabetes mellitus and protein disease were the independent risk factors of cognitive function in elderly patients with LI(P<0.05 to P<0.01).Conclusions:The elderly LI patients complicated with cognitive dysfunction is often,and the visuospatial/executive function,attention,language,memory disorders are the major performances,the cognitive dysfunction in bilateral or left side lesions patients is more obvious,the lesion location,severe protein lesion,hypertension and diabetes are the related risk factors affecting the cognitive dysfunction in elderly patients with LI.
Objective:To investigate the clinical factors of cognitive impairment in elderly patients with lacunar infarction(LI),and provide reference in improving the cognitive function of patients.Methods:One hundred and seventeen elderly patients with LI(LI group) were subdivided into the bilateral group,left group and right group according to the lesion location,and 100 healthy people were set as the control group.The score of Montreal cognitive assessment scale(MoCA) between two groups was compared.The influencing factors of cognitive function in elderly patients with LI were analyzed using the single factor analysis and multi factor logistic regression analysis.Results:Among 117 cases,the total score of MoCA was(24.92±2.96),the cognitive dysfunction in 64 cases(54.70%) were found.The delayed recall,attention,language,visual space/executive function and MoCA score in LI group were lower than those in control group(P<0.05 to P<0.01).The delayed recall,language,visual space/executive function and MoCA score in right group were higher than those in bilateral group and left group(P<0.05 to P<0.01),and which in left group was higher than that in bilateral group(P<0.05 to P<0.01).The attention score in right group was higher than that in bilateral group(P<0.01).The analysis result of influencing factors showed that the lesion location,hypertension,diabetes mellitus and protein disease were the independent risk factors of cognitive function in elderly patients with LI(P<0.05 to P<0.01).Conclusions:The elderly LI patients complicated with cognitive dysfunction is often,and the visuospatial/executive function,attention,language,memory disorders are the major performances,the cognitive dysfunction in bilateral or left side lesions patients is more obvious,the lesion location,severe protein lesion,hypertension and diabetes are the related risk factors affecting the cognitive dysfunction in elderly patients with LI.
2018, 43(3): 324-328.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.013
Abstract:
Objective:To explore the effects of large dose of rosuvastatin on oxidative stress and hemorheology in patients with coronary heart disease complicated with heart failure.Methods:One hundred and seventeen patients with coronary heart disease complicated with heart failure were randomly divided into the group A,B and C(39 cases each group).Three groups were treated with conventional treatment of heart failure,and the group A,B and C were additionally treated with 10,20 and 40 mg/d of rosuvastatin for 1 month,respectively.The heart color ultrasound index,blood oxidative stress index,hemorheology,liver function-related enzyme(AST and ALT) and myocardial enzyme(LDH and CK) level between three groups before and after rosuvastatin treatment were compared.Results:After 1 month of rosuvastatin treatment,the left ventricular ejection fraction(LVEEF) in three groups significantly increased(P<0.01),and the left ventricule end-diastolic dimension(LVEDD) and left ventricular end-systolic dimension(LVESD) in three groups significantly decreased(P<0.05 to P<0.01).The LVEFF in group C was significantly higher than that in group A and B,and the LVEDD and LVESD in group C were significantly lower than those in group A and B(P<0.05~P<0.01).The levels of the nitric oxide,endothelin 1 and malondialdehyde in three groups significantly decreased,the level of superoxide disnmtase significantly increased(P<0.01),and the improvement in group C was better than that in group A and B(P<0.05 to P<0.01).After treatment,the hemorheology index in three groups decreased(P<0.05 to P<0.01),and the levels of blood viscosity,fibrinogen,total blood viscosity shear rate and relative blood viscosity shear rate in group C were lower than those in group A and B(P<0.05 to P<0.01).After treatment,the levels of AST and ALT in group B and C increased compared before treatment(P<0.05 to P<0.01),and the difference of which between three groups was not statistically significant(P>0.05).The levels of LDH and CK in three groups significantly decreased after treatment(P<0.01),and the levels of LDH and CK in group C were lower than those in group A and B(P<0.01).Conclusions:The large dose of rosuvastatin treating patients with coronary heart disease complicated with heart failure can improve the cardiac function and level of oxidative stress,regulate the hemorheology index,reduce the levels of myocardial enzyme and cause a mild rise in liver enzymes.
Objective:To explore the effects of large dose of rosuvastatin on oxidative stress and hemorheology in patients with coronary heart disease complicated with heart failure.Methods:One hundred and seventeen patients with coronary heart disease complicated with heart failure were randomly divided into the group A,B and C(39 cases each group).Three groups were treated with conventional treatment of heart failure,and the group A,B and C were additionally treated with 10,20 and 40 mg/d of rosuvastatin for 1 month,respectively.The heart color ultrasound index,blood oxidative stress index,hemorheology,liver function-related enzyme(AST and ALT) and myocardial enzyme(LDH and CK) level between three groups before and after rosuvastatin treatment were compared.Results:After 1 month of rosuvastatin treatment,the left ventricular ejection fraction(LVEEF) in three groups significantly increased(P<0.01),and the left ventricule end-diastolic dimension(LVEDD) and left ventricular end-systolic dimension(LVESD) in three groups significantly decreased(P<0.05 to P<0.01).The LVEFF in group C was significantly higher than that in group A and B,and the LVEDD and LVESD in group C were significantly lower than those in group A and B(P<0.05~P<0.01).The levels of the nitric oxide,endothelin 1 and malondialdehyde in three groups significantly decreased,the level of superoxide disnmtase significantly increased(P<0.01),and the improvement in group C was better than that in group A and B(P<0.05 to P<0.01).After treatment,the hemorheology index in three groups decreased(P<0.05 to P<0.01),and the levels of blood viscosity,fibrinogen,total blood viscosity shear rate and relative blood viscosity shear rate in group C were lower than those in group A and B(P<0.05 to P<0.01).After treatment,the levels of AST and ALT in group B and C increased compared before treatment(P<0.05 to P<0.01),and the difference of which between three groups was not statistically significant(P>0.05).The levels of LDH and CK in three groups significantly decreased after treatment(P<0.01),and the levels of LDH and CK in group C were lower than those in group A and B(P<0.01).Conclusions:The large dose of rosuvastatin treating patients with coronary heart disease complicated with heart failure can improve the cardiac function and level of oxidative stress,regulate the hemorheology index,reduce the levels of myocardial enzyme and cause a mild rise in liver enzymes.
2018, 43(3): 329-331.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.014
Abstract:
Objective:To investigate the expression level of CD4+CD25+CD127- regulatory T cells(Treg) in peripheral blood of patients with cervical cancer,and its clinical significance.Methods:The clinical data of 65 patients with cervical cancer were retrospectively analyzed,and set as the cervical cancer group.Sixty patients with uterine myoma and 60 healthy women were divided into the uterine myoma group and control group,respectively.The proportions of CD4+CD25+CD127- Treg to CD4+CD25+T cells of peripheral blood were detected using flow cytometry,and the difference of which between three groups was compared.The correlations of the expression level of CD4+CD25+CD127- Treg in peripheral blood with the cancer clinical stage,myometrial invasion,tumor differentiation and lymph node metastasis were analyzed.Results:The ratio of CD4+CD25+CD127-Treg to CD4+CD25+ T cells in peripheral blood in cervical cancer group was significantly higher than that in other two groups(P<0.01),and which in uterine myoma group was significantly higher than that in control group(P<0.01).The differences of the ratio of CD4+CD25+CD127-Treg/CD4+CD25+ T cells in different clinical stage,pathological grade,infiltration depth and lymph node metastasis were statistically significant(P<0.05 to P<0.01).Conclusions:The expression level of CD4+CD25+CD127-Treg is correlation with the incidence and development of cervical cancer in some degree,which has important significance in evaluating the progress of cervical cancer.
Objective:To investigate the expression level of CD4+CD25+CD127- regulatory T cells(Treg) in peripheral blood of patients with cervical cancer,and its clinical significance.Methods:The clinical data of 65 patients with cervical cancer were retrospectively analyzed,and set as the cervical cancer group.Sixty patients with uterine myoma and 60 healthy women were divided into the uterine myoma group and control group,respectively.The proportions of CD4+CD25+CD127- Treg to CD4+CD25+T cells of peripheral blood were detected using flow cytometry,and the difference of which between three groups was compared.The correlations of the expression level of CD4+CD25+CD127- Treg in peripheral blood with the cancer clinical stage,myometrial invasion,tumor differentiation and lymph node metastasis were analyzed.Results:The ratio of CD4+CD25+CD127-Treg to CD4+CD25+ T cells in peripheral blood in cervical cancer group was significantly higher than that in other two groups(P<0.01),and which in uterine myoma group was significantly higher than that in control group(P<0.01).The differences of the ratio of CD4+CD25+CD127-Treg/CD4+CD25+ T cells in different clinical stage,pathological grade,infiltration depth and lymph node metastasis were statistically significant(P<0.05 to P<0.01).Conclusions:The expression level of CD4+CD25+CD127-Treg is correlation with the incidence and development of cervical cancer in some degree,which has important significance in evaluating the progress of cervical cancer.
2018, 43(3): 332-335.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.015
Abstract:
Objective:To investigate the change rule of standing stability in hemiplegic patients with cerebral infarction under the condition of the static opening or closing eye,and various compensatory mechanisms effect on lower extremity stability.Methods:Forty-two left hemiplegic patients with first time cerebral infarction and independent standing more than 10 m,and 36 healthy middle aged and elderly people were divide into the case group and control group,respectively.Two groups were detected using PK254 equilibrium tester and PDM-THM gait training treadmill.Results:Under the condition of opening eye,the differences of the path length of center of pressure(COP) and moving average speed between two groups were not statistically significant(P>0.05),the pressure distribution proportion of the corresponding left front foot and rear foot between two group were not statistically significant(P>0.05),the total pressure distribution proportion of left side and pressure distribution proportion of right front foot in case group were higher than those in control group(P<0.05 and P<0.01),and the pressure distribution proportion of right rear foot and total pressure distribution proportion of right side in case group were lower than those in control group(P<0.01).Under the condition of closing eye,the path length and moving average speed of COP in case group were higher than those in control group(P<0.01).The pressure distribution proportion of the corresponding right front foot in case group was lower than those in control group(P<0.01),the pressure distribution proportion of right rear foot and total pressure distribution proportion of right side in case group were higher than those in control group(P<0.05),and the differences of the total pressure distribution proportions of left front foot,left rear foot and left side between two groups were not statistical significance(P>0.05).Conclusions:The standing stability in hemiplegic patients with cerebral infarction can be significantly improved by visual compensation.The standing stability of lower limb in hemiplegia patients can be better improved by the regulation of vestibular and proprioception.After hemiplegia,the standing stability of healthy side lower limb of patients can be significantly affected compared with normal.
Objective:To investigate the change rule of standing stability in hemiplegic patients with cerebral infarction under the condition of the static opening or closing eye,and various compensatory mechanisms effect on lower extremity stability.Methods:Forty-two left hemiplegic patients with first time cerebral infarction and independent standing more than 10 m,and 36 healthy middle aged and elderly people were divide into the case group and control group,respectively.Two groups were detected using PK254 equilibrium tester and PDM-THM gait training treadmill.Results:Under the condition of opening eye,the differences of the path length of center of pressure(COP) and moving average speed between two groups were not statistically significant(P>0.05),the pressure distribution proportion of the corresponding left front foot and rear foot between two group were not statistically significant(P>0.05),the total pressure distribution proportion of left side and pressure distribution proportion of right front foot in case group were higher than those in control group(P<0.05 and P<0.01),and the pressure distribution proportion of right rear foot and total pressure distribution proportion of right side in case group were lower than those in control group(P<0.01).Under the condition of closing eye,the path length and moving average speed of COP in case group were higher than those in control group(P<0.01).The pressure distribution proportion of the corresponding right front foot in case group was lower than those in control group(P<0.01),the pressure distribution proportion of right rear foot and total pressure distribution proportion of right side in case group were higher than those in control group(P<0.05),and the differences of the total pressure distribution proportions of left front foot,left rear foot and left side between two groups were not statistical significance(P>0.05).Conclusions:The standing stability in hemiplegic patients with cerebral infarction can be significantly improved by visual compensation.The standing stability of lower limb in hemiplegia patients can be better improved by the regulation of vestibular and proprioception.After hemiplegia,the standing stability of healthy side lower limb of patients can be significantly affected compared with normal.
2018, 43(3): 336-337.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.016
Abstract:
Objective:To explore the curative effects of endoscopic sinus surgery in the treatment of sinusitis and nasal polyp and its effect on nasal airflow.Methods:Ninety patients with sinusitis and nasal polyps were divided into the observation group and control group according to random number table method(45 cases each group).The control group and observation group were treated with conventional surgery and sinus endoscopy,respectively.The clinical curative effect,nasal airflow before and after operation,olfactory function between two groups were compared.Results:The clinical total effective rate in observation group(93.33%) was higher than that in control group(77.78%) (P<0.05).Compared before operation,the postoperative nasal airway resistance and scores of olfactory function in two groups decreased,and the improvement degree of which in observation group was better than that in control group(P<0.01).Conclusions:The clinical effect of endoscopic sinus surgery in the treatment of sinusitis and nasal polyp is better than that of traditional surgery,which can effectively improve the condition of nasal ventilation airflow and smell function.
Objective:To explore the curative effects of endoscopic sinus surgery in the treatment of sinusitis and nasal polyp and its effect on nasal airflow.Methods:Ninety patients with sinusitis and nasal polyps were divided into the observation group and control group according to random number table method(45 cases each group).The control group and observation group were treated with conventional surgery and sinus endoscopy,respectively.The clinical curative effect,nasal airflow before and after operation,olfactory function between two groups were compared.Results:The clinical total effective rate in observation group(93.33%) was higher than that in control group(77.78%) (P<0.05).Compared before operation,the postoperative nasal airway resistance and scores of olfactory function in two groups decreased,and the improvement degree of which in observation group was better than that in control group(P<0.01).Conclusions:The clinical effect of endoscopic sinus surgery in the treatment of sinusitis and nasal polyp is better than that of traditional surgery,which can effectively improve the condition of nasal ventilation airflow and smell function.
2018, 43(3): 338-340.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.017
Abstract:
Objective:To investigate the clinical efficacy and safety of mouse nerve growth factor(mNGF) in the treatment of post-herpetic neuralgia(PHN) in old patients.Methods:Fifty old patients with PHN were randomly divided into the observation group(n=25) and control group(n=25).The observation group were treated with 20 μg mNGF by intramuscular injection once a day,and the control group were treated with 500 μg vitamin B12 once a day for 14 days.The clinical efficacy in two groups were evaluated using visual analogue scale before and after treatment,and the adverse action in two groups were recorded.Results:The VAS score of the observation group was significantly lower than that of the control group(P<0.01).The total effective rate,degree of pain relief and pain disappear time in observation group were significantly better those in control group(P<0.01).Conclusions:mNGF in the treatment of PHN was effective and safe.
Objective:To investigate the clinical efficacy and safety of mouse nerve growth factor(mNGF) in the treatment of post-herpetic neuralgia(PHN) in old patients.Methods:Fifty old patients with PHN were randomly divided into the observation group(n=25) and control group(n=25).The observation group were treated with 20 μg mNGF by intramuscular injection once a day,and the control group were treated with 500 μg vitamin B12 once a day for 14 days.The clinical efficacy in two groups were evaluated using visual analogue scale before and after treatment,and the adverse action in two groups were recorded.Results:The VAS score of the observation group was significantly lower than that of the control group(P<0.01).The total effective rate,degree of pain relief and pain disappear time in observation group were significantly better those in control group(P<0.01).Conclusions:mNGF in the treatment of PHN was effective and safe.
2018, 43(3): 341-343,347.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.018
Abstract:
Objective:To investigate the causes of weaning failure in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) after invasive mechanical ventilation.Methods:The clinical data of 78 AECOPD patients treated with mechanical ventilation were retrospectively analyzed.According to the success weaning of patients,the relationships between the age,duration of COPD,duration of invasive ventilation,mean arterial pressure,serum albumin level,acute physiology and chronic health Ⅱ scores,ICU stay time,underlying diseases(such as hypertension,diabetes,hyperlipidemia,etc.) and weaning failure were analyzed using logistic regression analysis method.Results:Among 78 patients,the weaning success in 53 cases(67.95%) and weaning failure in 25 cases(32.05%) were found.The results of logistic regression analysis showed that the old age,long duration of invasive ventilation,low serum albumin and hypertension or diabetes mellitus were the independent risk factors of invasive ventilatory failure in AECOPD patients(P<0.01).Conclusions:A variety of factors can lead to the failure of invasive mechanical ventilation in patients with AECOPD.The old age,long invasive ventilation,low serum albumin,and hypertension or diabetes mellitus are the independent risk factors of invasive ventilatory failure in AECOPD patients.
Objective:To investigate the causes of weaning failure in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) after invasive mechanical ventilation.Methods:The clinical data of 78 AECOPD patients treated with mechanical ventilation were retrospectively analyzed.According to the success weaning of patients,the relationships between the age,duration of COPD,duration of invasive ventilation,mean arterial pressure,serum albumin level,acute physiology and chronic health Ⅱ scores,ICU stay time,underlying diseases(such as hypertension,diabetes,hyperlipidemia,etc.) and weaning failure were analyzed using logistic regression analysis method.Results:Among 78 patients,the weaning success in 53 cases(67.95%) and weaning failure in 25 cases(32.05%) were found.The results of logistic regression analysis showed that the old age,long duration of invasive ventilation,low serum albumin and hypertension or diabetes mellitus were the independent risk factors of invasive ventilatory failure in AECOPD patients(P<0.01).Conclusions:A variety of factors can lead to the failure of invasive mechanical ventilation in patients with AECOPD.The old age,long invasive ventilation,low serum albumin,and hypertension or diabetes mellitus are the independent risk factors of invasive ventilatory failure in AECOPD patients.
2018, 43(3): 344-347.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.019
Abstract:
Objective:To study the impact of pre-pregnancy maternal body mass index(BMI) on neonatal birth weight in women with gestational diabetes mellitus(GDM).Methods:This was a prospective cohort study with sampling in singleton pregnant women diagnosed of GDM between April,2015and December,2015 and tracking their pregnancy outcomes.Binary logistic regression was used to analyze the influencing factors for macrosomia.Besides,the associations between pre-pregnancy maternal BMI,GWG and neonatal birth weight were also explored.Results:A total of 590 women eligible for analysis.Pre-pregnancy BMI categories were:thin[10.6%(63/590)],normal[65.9%(389/590)],overweight[17.6%(104/590)] and obese[5.9%(34/590)].The mean birth weight was(3 348.6±465.4) g.The incidence of macrosomia was 7.6%(45/590) and low birth weight 2.4%(14/590).With the increase of pre-pregnancy BMI,the incidence of excessive GWG,macrosomia,low birth weight and cesarean section significantly increased;moreover,the rate of macrosomia significantly increased as the GWG increased(P<0.01).Logistic regression analysis showed that,gestational weeks,neonatal sex and GWG were associated with macrosomia,while pre-pregnancy BMI was not significantly associated with macrosomia.When compared to pregnant women with normal GWG,excessive GWG appeared to be the risk factor of macrosomia,with the odds ratio(OR) as 2.57(P<0.01).Conclusions:Much more attention should be paid to women who are planning to get pregnancy and control the weight gain within the normal range during pregnancy,especially in the population of overweight and obese women with GDM.
Objective:To study the impact of pre-pregnancy maternal body mass index(BMI) on neonatal birth weight in women with gestational diabetes mellitus(GDM).Methods:This was a prospective cohort study with sampling in singleton pregnant women diagnosed of GDM between April,2015and December,2015 and tracking their pregnancy outcomes.Binary logistic regression was used to analyze the influencing factors for macrosomia.Besides,the associations between pre-pregnancy maternal BMI,GWG and neonatal birth weight were also explored.Results:A total of 590 women eligible for analysis.Pre-pregnancy BMI categories were:thin[10.6%(63/590)],normal[65.9%(389/590)],overweight[17.6%(104/590)] and obese[5.9%(34/590)].The mean birth weight was(3 348.6±465.4) g.The incidence of macrosomia was 7.6%(45/590) and low birth weight 2.4%(14/590).With the increase of pre-pregnancy BMI,the incidence of excessive GWG,macrosomia,low birth weight and cesarean section significantly increased;moreover,the rate of macrosomia significantly increased as the GWG increased(P<0.01).Logistic regression analysis showed that,gestational weeks,neonatal sex and GWG were associated with macrosomia,while pre-pregnancy BMI was not significantly associated with macrosomia.When compared to pregnant women with normal GWG,excessive GWG appeared to be the risk factor of macrosomia,with the odds ratio(OR) as 2.57(P<0.01).Conclusions:Much more attention should be paid to women who are planning to get pregnancy and control the weight gain within the normal range during pregnancy,especially in the population of overweight and obese women with GDM.
2018, 43(3): 348-350.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.020
Abstract:
Objective:To investigate the effects of de-escalation treatment of antibiotic on the serum vitamin D in children with severe asthmatic.Methods:One hundred and ninety children with severe asthmatic were randomly divided into the treatment group and control group according to the random draw principle(95 cases each group).The control group and treatment group were treated with routine antibiotic and de-escalation of antibiotic for 7 days,respectively.Results:The total effective rate in treatment group(97.9%) was significantly higher than that in control group(88.4%) (P<0.01).The disappearance time of wheezing and pulmonary rale,and hospitalization time in treatment group[(3.14±0.34) d,(4.63±0.45) d and(9.39±3.22) d] were significantly less than those in control group[(4.22±0.45) d,(7.82±0.56) d and(11.45±2.95) d],respectively(P<0.01).The levels of serum vitamin 25(OH) D in treatment group and control group after treatment[(53.24±9.45) ng/mL and(45.39±10.22) ng/mL] were significantly higher than those before treatment[(28.24±9.33) ng/mL and(28.11±8.97) ng/mL],respectively(P<0.01),and the increasing degree of which in treatment group was higher than that in control group(P<0.01).Conclusions:The de-escalation treatment of antibiotic in children with severe asthmatic can increase the serum vitamin 25(OH) D content,improve the overall treatment effect,and promote the rehabilitation of children.
Objective:To investigate the effects of de-escalation treatment of antibiotic on the serum vitamin D in children with severe asthmatic.Methods:One hundred and ninety children with severe asthmatic were randomly divided into the treatment group and control group according to the random draw principle(95 cases each group).The control group and treatment group were treated with routine antibiotic and de-escalation of antibiotic for 7 days,respectively.Results:The total effective rate in treatment group(97.9%) was significantly higher than that in control group(88.4%) (P<0.01).The disappearance time of wheezing and pulmonary rale,and hospitalization time in treatment group[(3.14±0.34) d,(4.63±0.45) d and(9.39±3.22) d] were significantly less than those in control group[(4.22±0.45) d,(7.82±0.56) d and(11.45±2.95) d],respectively(P<0.01).The levels of serum vitamin 25(OH) D in treatment group and control group after treatment[(53.24±9.45) ng/mL and(45.39±10.22) ng/mL] were significantly higher than those before treatment[(28.24±9.33) ng/mL and(28.11±8.97) ng/mL],respectively(P<0.01),and the increasing degree of which in treatment group was higher than that in control group(P<0.01).Conclusions:The de-escalation treatment of antibiotic in children with severe asthmatic can increase the serum vitamin 25(OH) D content,improve the overall treatment effect,and promote the rehabilitation of children.
2018, 43(3): 351-354,357.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.021
Abstract:
Objective:To explore the effects of the different tidal volume of mechanical ventilation on postoperative old patients with lung cancer.Methods:One hundred postoperative elderly patients with lung cancer were divided into the 6 mL/kg group(group A),8 mL/kg group(group B) and 10 mL/kg(group C) according to the tidal volume of mechanical ventilation.The postoperative blood gas analysis indicators,related inflammatory factors,respiratory indexes and complications between three groups were compared.Results:At timepoint T1,T2 and T3,the levels of PETCO2 in group B and C were lower than that in group A(P<0.05),which in group C was significantly lower than that in group B(P<0.01).The peak airway pressure level in group C was significantly higher than that in group A and B(P<0.01).The differences of the levels of PETCO2 between timepoint T1,T2 and T3 in group A and B were not statistically significant(P>0.05).The differences of the levels of PETCO2 between timepoint T1,T2 and T3 in group C were statistically significant(P<0.01),and which at T2 and T3 was significantly lower than that at timepoint T1(P<0.01).The differences of the levels of peak airway pressure between three groups at timepoint T1,T2 and T3 were statistically significant(P<0.01),which at timepoint T3 in group A and B were higher than that at timepoint T1 and T2(P<0.01),and which at timepoint T2 and T3 in group C were significantly higher than that at timepoint T1(P<0.01).There were statistical significances in the level of IL-1β between three groups at timepoint T2(P<0.01),which in group B and C was lower than that in group A(P<0.05).There were statistical significances in the level of IL-6 between three groups at timepoint T2 and T3(P<0.01),which in group B at timepoint T2 and T3 were lower than that in group A(P<0.05),and which in group C at timepoint T3 was higher than that in group A(P<0.05).There were statistical significances in lung compliance indicators between three groups at timepoint T1,T2 and T3(P<0.01),which in group B and C were lower than that in group A(P<0.01),and which in group C at timepoint T2 and T3 were significantly higher than that in group B(P<0.01).There were statistical significances in overall complications between three groups(P<0.05),and which in group B significantly decreased(P<0.05).Conclusions:The effects of 8 mL/kg tidal volume of mechanical ventilation on the postoperative blood gas index,inflammatory factors and complications in elderly patients with lung cancer is little,which does not affect the lung ventilation function,and is a reasonable tidal volume of mechanical ventilation.
Objective:To explore the effects of the different tidal volume of mechanical ventilation on postoperative old patients with lung cancer.Methods:One hundred postoperative elderly patients with lung cancer were divided into the 6 mL/kg group(group A),8 mL/kg group(group B) and 10 mL/kg(group C) according to the tidal volume of mechanical ventilation.The postoperative blood gas analysis indicators,related inflammatory factors,respiratory indexes and complications between three groups were compared.Results:At timepoint T1,T2 and T3,the levels of PETCO2 in group B and C were lower than that in group A(P<0.05),which in group C was significantly lower than that in group B(P<0.01).The peak airway pressure level in group C was significantly higher than that in group A and B(P<0.01).The differences of the levels of PETCO2 between timepoint T1,T2 and T3 in group A and B were not statistically significant(P>0.05).The differences of the levels of PETCO2 between timepoint T1,T2 and T3 in group C were statistically significant(P<0.01),and which at T2 and T3 was significantly lower than that at timepoint T1(P<0.01).The differences of the levels of peak airway pressure between three groups at timepoint T1,T2 and T3 were statistically significant(P<0.01),which at timepoint T3 in group A and B were higher than that at timepoint T1 and T2(P<0.01),and which at timepoint T2 and T3 in group C were significantly higher than that at timepoint T1(P<0.01).There were statistical significances in the level of IL-1β between three groups at timepoint T2(P<0.01),which in group B and C was lower than that in group A(P<0.05).There were statistical significances in the level of IL-6 between three groups at timepoint T2 and T3(P<0.01),which in group B at timepoint T2 and T3 were lower than that in group A(P<0.05),and which in group C at timepoint T3 was higher than that in group A(P<0.05).There were statistical significances in lung compliance indicators between three groups at timepoint T1,T2 and T3(P<0.01),which in group B and C were lower than that in group A(P<0.01),and which in group C at timepoint T2 and T3 were significantly higher than that in group B(P<0.01).There were statistical significances in overall complications between three groups(P<0.05),and which in group B significantly decreased(P<0.05).Conclusions:The effects of 8 mL/kg tidal volume of mechanical ventilation on the postoperative blood gas index,inflammatory factors and complications in elderly patients with lung cancer is little,which does not affect the lung ventilation function,and is a reasonable tidal volume of mechanical ventilation.
2018, 43(3): 355-357.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.022
Abstract:
Objective:To observe the clinical effects of pidomode in the treatment of lobar Mycoplasma pneumoniae pneumonia(MPP) in children,and evaluate its effect on cellular immune function.Methods:Forty-four children with lobar MPP were randomly divided into group A and group B,and 30 healthy children were set as control group.Group B were treated with azithromycin(10 mg·kg-1·d-1 each time) for 3 courses of treatmemt,and the group A were treated with azithromycin combined with pidotimod(0.4 g/d) for 2 months.The levels of T lymphocyte subsets in three group before treatment and after 2 months of treatment were detected using flow cytometry,and the clinical effect between group A and B was compared.Results:Before treatment,the serum levels of CD3+,CD4+ and CD4+/CD8+ in lobar MPP group significantly decreased,and the level of CD8+ increased compared with the control group(P<0.01).After treatment,the serum levels of CD3+,CD4+ and CD4+/CD8+ in group A significantly increased compared with before treatment(P<0.01),and the difference of which in group B between before and after treatment was not statistically significant(P>0.05).After treatment,the differences of the serum levels of CD3+,CD4+ and CD4+/CD8+ between group A and group B were statistically significant(P<0.01),and the difference of the level of serum CD8+ in two groups between before and after treatment was not statistically significant(P>0.05).From the beginning of treatment to follow for 6 months,the clinical curative effect in group A was better than that in group B(P<0.01).Conclusions:Cellular immune function disorder exists in lobar MPP,pidotimod can regulate the immune balance,strengthen immunity,and improve the clinical curative effect in children with lobar MPP.
Objective:To observe the clinical effects of pidomode in the treatment of lobar Mycoplasma pneumoniae pneumonia(MPP) in children,and evaluate its effect on cellular immune function.Methods:Forty-four children with lobar MPP were randomly divided into group A and group B,and 30 healthy children were set as control group.Group B were treated with azithromycin(10 mg·kg-1·d-1 each time) for 3 courses of treatmemt,and the group A were treated with azithromycin combined with pidotimod(0.4 g/d) for 2 months.The levels of T lymphocyte subsets in three group before treatment and after 2 months of treatment were detected using flow cytometry,and the clinical effect between group A and B was compared.Results:Before treatment,the serum levels of CD3+,CD4+ and CD4+/CD8+ in lobar MPP group significantly decreased,and the level of CD8+ increased compared with the control group(P<0.01).After treatment,the serum levels of CD3+,CD4+ and CD4+/CD8+ in group A significantly increased compared with before treatment(P<0.01),and the difference of which in group B between before and after treatment was not statistically significant(P>0.05).After treatment,the differences of the serum levels of CD3+,CD4+ and CD4+/CD8+ between group A and group B were statistically significant(P<0.01),and the difference of the level of serum CD8+ in two groups between before and after treatment was not statistically significant(P>0.05).From the beginning of treatment to follow for 6 months,the clinical curative effect in group A was better than that in group B(P<0.01).Conclusions:Cellular immune function disorder exists in lobar MPP,pidotimod can regulate the immune balance,strengthen immunity,and improve the clinical curative effect in children with lobar MPP.
2018, 43(3): 360-362.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.024
Abstract:
Objective:To investigate the job satisfaction of medical staff from township hospitals in Northern Anhui and its influence factors.Methods:The job satisfaction of 477 medical staff from 27 township hospitals in Northern Anhui selected by stratified random sampling method were investigated using self-made job satisfaction questionnaire.Results:The overall satisfaction score of medical staff from township hospitals in Northern Anhui was(3.67±0.82).The satisfaction scores of work environment,work itself,hospital management,social practice environment and salary were(3.85±0.80),(3.77±1.04),(3.71±0.64),(3.64±0.68) and(3.38±0.93),respectively.The differences of satisfaction scores of different ages,marital status and length of service were statistically significant(P < 0.01).Conclusions:The professional development and improving the salary system of medical staff in township hospitals should be taken as the breakthrough point in strengthening the construction of medical and health teams,and the targeted measures to different groups should be paid attention to.
Objective:To investigate the job satisfaction of medical staff from township hospitals in Northern Anhui and its influence factors.Methods:The job satisfaction of 477 medical staff from 27 township hospitals in Northern Anhui selected by stratified random sampling method were investigated using self-made job satisfaction questionnaire.Results:The overall satisfaction score of medical staff from township hospitals in Northern Anhui was(3.67±0.82).The satisfaction scores of work environment,work itself,hospital management,social practice environment and salary were(3.85±0.80),(3.77±1.04),(3.71±0.64),(3.64±0.68) and(3.38±0.93),respectively.The differences of satisfaction scores of different ages,marital status and length of service were statistically significant(P < 0.01).Conclusions:The professional development and improving the salary system of medical staff in township hospitals should be taken as the breakthrough point in strengthening the construction of medical and health teams,and the targeted measures to different groups should be paid attention to.
2018, 43(3): 363-366,370.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.025
Abstract:
Objective:To understand the smoking risk cognition of male smoking students in medical college,and explore the subjective factor of smoking behavior.Methods:Thirteen male smoking medical college students were deeply investigated using the phenomenological methodology.Results:The smoking risk cognition of male smoking students in medical college included the acquiring way of smoking risk cognition,awareness of the potential risk of smoking,and life attitude.Conclusions:The harmful to health of smoking is not an promoting factor of quitting smoking,and the one-sidedness of smoking risk cognition and negative life attitude are the potential subjective factors of smoking behavior.Before intervening the smoking behavior among medical students,the smoking risk awareness and values should be correctly established at first.
Objective:To understand the smoking risk cognition of male smoking students in medical college,and explore the subjective factor of smoking behavior.Methods:Thirteen male smoking medical college students were deeply investigated using the phenomenological methodology.Results:The smoking risk cognition of male smoking students in medical college included the acquiring way of smoking risk cognition,awareness of the potential risk of smoking,and life attitude.Conclusions:The harmful to health of smoking is not an promoting factor of quitting smoking,and the one-sidedness of smoking risk cognition and negative life attitude are the potential subjective factors of smoking behavior.Before intervening the smoking behavior among medical students,the smoking risk awareness and values should be correctly established at first.
2018, 43(3): 367-370.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.026
Abstract:
Objective:To investigate the practice mode reform and satisfaction of general practitioners in Anhui province and its influencing factors.Methods:Using a self-administered questionnaire survey,a total of 50 primary medical and health institutions(including the community health service center and township health center) were selected in Anhui.The basic information of the subjects,cognition of reform in practice,contract with the residents and satisfaction degree with the practice were investigated.Results:Among the 387 general practitioners,178(46.00%) doctors knew that physicians can conduct in multi-site practice,199(51.42%) doctors supported multi-site practice,128(33.07%) doctors thought that their unit supported multi-site practice,219(56.59%) doctors unit signed the contract service with the residents,228(58.92%) doctors supported the contract services,244(63.05%) doctors were in favor of patient selecting doctor,and 142(36.68%) agreed with the doctor choosing patient.The proportions of dissatisfaction from high to low were bonus allocation(37.98%),working load(36.69%),doctor-patient relationship(33.07%),working environment(27.91%) and working content(27.39%) in turn.The main reasons restricting general practitioners' multi-site practice were the related facilities service imperfect(33.67%),unit system restriction(32.81%),heavy work pressure(12.51%),and lack of general practitioners(17.29%) in turn.Conclusions:General practitioners in Anhui have high positivity in the reform of the practice and low satisfaction with practice,and many factors restrict the multi-site practice of general practitioners.Strengthening the related facilities construction of multi-site practice,setting the multi-site practice standard,guiding the multi-site practice,improving unit system and rational formulating assignment system can improve the satisfaction degree of general practitioners with practice.
Objective:To investigate the practice mode reform and satisfaction of general practitioners in Anhui province and its influencing factors.Methods:Using a self-administered questionnaire survey,a total of 50 primary medical and health institutions(including the community health service center and township health center) were selected in Anhui.The basic information of the subjects,cognition of reform in practice,contract with the residents and satisfaction degree with the practice were investigated.Results:Among the 387 general practitioners,178(46.00%) doctors knew that physicians can conduct in multi-site practice,199(51.42%) doctors supported multi-site practice,128(33.07%) doctors thought that their unit supported multi-site practice,219(56.59%) doctors unit signed the contract service with the residents,228(58.92%) doctors supported the contract services,244(63.05%) doctors were in favor of patient selecting doctor,and 142(36.68%) agreed with the doctor choosing patient.The proportions of dissatisfaction from high to low were bonus allocation(37.98%),working load(36.69%),doctor-patient relationship(33.07%),working environment(27.91%) and working content(27.39%) in turn.The main reasons restricting general practitioners' multi-site practice were the related facilities service imperfect(33.67%),unit system restriction(32.81%),heavy work pressure(12.51%),and lack of general practitioners(17.29%) in turn.Conclusions:General practitioners in Anhui have high positivity in the reform of the practice and low satisfaction with practice,and many factors restrict the multi-site practice of general practitioners.Strengthening the related facilities construction of multi-site practice,setting the multi-site practice standard,guiding the multi-site practice,improving unit system and rational formulating assignment system can improve the satisfaction degree of general practitioners with practice.
2018, 43(3): 371-373,378.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.027
Abstract:
Objective:To investigate the clinical value of the high frequency color Doppler ultrasound examination in infertility patients with varicocele(VC),and explore the indictor change of semen in different classifications patients with VC.Methods:One hundred and twenty-four infertility male patients with left VC were investigated,and 41 cases of healthy childbearing age men were set as the control group.The DR,DV,Vmax and TR of spermatic vein were detected using high frequency ultrasound Doppler,and the semen volume and sperm concentration,vitality and form were analyzed using WEILI image analysis system.Results:The DR,DV,Vmax and TR in SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups were significantly higher than those in control group(P<0.01).The DR,DV,Vmax and TR in SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups gradually increased,and the differences of whose between SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups were statistically significant(P<0.01).The left testicular volume in SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups gradually decreased,and whose were significantly lower than that in control group(P<0.05 to P<0.01).The right testicular volume gradually decreased in each group,but which only in VC Ⅱ group was lower than that in control group(P<0.05).The sperm concentration,sperm vitality,percentage of forward movement sperm,sperm survival rate and normal form in SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups gradually decreased,and the differences of whose in all groups were statistically significant(P< 0.05 to P<0.01).Conclusions:High frequency color Doppler ultrasound can objectively reflect the testicular volume,spermatic vein diameter and hemodynamic index,and which combined with semen parameters have good predictive value in male infertility.
Objective:To investigate the clinical value of the high frequency color Doppler ultrasound examination in infertility patients with varicocele(VC),and explore the indictor change of semen in different classifications patients with VC.Methods:One hundred and twenty-four infertility male patients with left VC were investigated,and 41 cases of healthy childbearing age men were set as the control group.The DR,DV,Vmax and TR of spermatic vein were detected using high frequency ultrasound Doppler,and the semen volume and sperm concentration,vitality and form were analyzed using WEILI image analysis system.Results:The DR,DV,Vmax and TR in SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups were significantly higher than those in control group(P<0.01).The DR,DV,Vmax and TR in SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups gradually increased,and the differences of whose between SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups were statistically significant(P<0.01).The left testicular volume in SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups gradually decreased,and whose were significantly lower than that in control group(P<0.05 to P<0.01).The right testicular volume gradually decreased in each group,but which only in VC Ⅱ group was lower than that in control group(P<0.05).The sperm concentration,sperm vitality,percentage of forward movement sperm,sperm survival rate and normal form in SVC,VC Ⅰ,VC Ⅱ and VC Ⅲ groups gradually decreased,and the differences of whose in all groups were statistically significant(P< 0.05 to P<0.01).Conclusions:High frequency color Doppler ultrasound can objectively reflect the testicular volume,spermatic vein diameter and hemodynamic index,and which combined with semen parameters have good predictive value in male infertility.
2018, 43(3): 374-378.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.028
Abstract:
Objective:To analyze the imaging features of lung high resolution CT(HRCT) in different connective tissue disease(CTD) complicated with interstitial pneumonia(ILD),and provide the basis for the HRCT in the early diagnosis of CTD complicated with ILD.Methods:Among 1388 patients with CTD,the imaging features of pulmonary HRCT in 143 patients with CTD complicated with ILD(total incidence rate for 10.3%) were investigated.The relationship between CT classification and different CTD laboratory indexes were analyzed.Results:Among 143 patients with CTD complicated with ILD,the systemic lupus erythematosus(SLE) in 53 cases,rheumatoid arthritis(RA) in 40 cases,sicca syndrome in 24 cases,polymyositis/dermatomyositis in 8 cases,systemic sclerosis(SSc) in 7 cases,mixed connective tissue disease(MTCD) and adult onset still's disease(AOSD) in 4 cases were identified.The imaging features of HRCT in patients with CTD complicated with ILD mainly included the septal thickening(88.1%),ground-glass opacity(78.3%),irregular linear opacities or subpleural line(74.1%),grid shadow(41.3%),bronchovascular bundle thickening(30.1%),thin-walled cyst(23.8%),honeycomb lung(19.6%),focal nodules(19.6%),mosaic perfusion opacities(10.5%),consolidation shadow(10.5%) and pulmonary bullae(5.6%).The ground-glass opacity and lobular interval thickening were the main imaging features of SLE,RA,SS and AOSD,and the grid shadow and honeycomb lung were the main imaging features of SSc,PM/DM and MCTD.The differences of the levels of ESR,CRP,C3 and C4 between different CT types of lung interstitial lesions were statistically significant(P<0.01).The ESR indexes in the grid shadow group,real shadow group,honeycomb lung group,ground-glass opacity and non-ILD group were higher than those in irregular line group or subpleural group(P<0.05 to P<0.01).The CRP indexes in the real shadow group,honeycomb lung group and ground-glass opacity group were higher than those in non-ILD group(P<0.05 to P<0.01).The C3 indexes in the irregular line group or subpleural group,thin-walled cysts group,bronchial tube bundle thickening group,honeycomb lung group,lobular interval thickening group and non-ILD group were lower than those in ground-glass opacity group(P<0.05 to P<0.01).The C3 indexes in irregular line group or subpleural group and real shadow group were higher than those in non-ILD group(P<0.05 to P<0.01).In addition to the pulmonary bullae group,the C4 index in other groups were significantly lower than those in ground-glass opacity group(P<0.01).Conclusions:Different CTD complicated with ILD have different imaging features,inflammation indexes and complement levels.The early lung HRCT examination is helpful to the early diagnosis of ILD,and predict the prognosis.
Objective:To analyze the imaging features of lung high resolution CT(HRCT) in different connective tissue disease(CTD) complicated with interstitial pneumonia(ILD),and provide the basis for the HRCT in the early diagnosis of CTD complicated with ILD.Methods:Among 1388 patients with CTD,the imaging features of pulmonary HRCT in 143 patients with CTD complicated with ILD(total incidence rate for 10.3%) were investigated.The relationship between CT classification and different CTD laboratory indexes were analyzed.Results:Among 143 patients with CTD complicated with ILD,the systemic lupus erythematosus(SLE) in 53 cases,rheumatoid arthritis(RA) in 40 cases,sicca syndrome in 24 cases,polymyositis/dermatomyositis in 8 cases,systemic sclerosis(SSc) in 7 cases,mixed connective tissue disease(MTCD) and adult onset still's disease(AOSD) in 4 cases were identified.The imaging features of HRCT in patients with CTD complicated with ILD mainly included the septal thickening(88.1%),ground-glass opacity(78.3%),irregular linear opacities or subpleural line(74.1%),grid shadow(41.3%),bronchovascular bundle thickening(30.1%),thin-walled cyst(23.8%),honeycomb lung(19.6%),focal nodules(19.6%),mosaic perfusion opacities(10.5%),consolidation shadow(10.5%) and pulmonary bullae(5.6%).The ground-glass opacity and lobular interval thickening were the main imaging features of SLE,RA,SS and AOSD,and the grid shadow and honeycomb lung were the main imaging features of SSc,PM/DM and MCTD.The differences of the levels of ESR,CRP,C3 and C4 between different CT types of lung interstitial lesions were statistically significant(P<0.01).The ESR indexes in the grid shadow group,real shadow group,honeycomb lung group,ground-glass opacity and non-ILD group were higher than those in irregular line group or subpleural group(P<0.05 to P<0.01).The CRP indexes in the real shadow group,honeycomb lung group and ground-glass opacity group were higher than those in non-ILD group(P<0.05 to P<0.01).The C3 indexes in the irregular line group or subpleural group,thin-walled cysts group,bronchial tube bundle thickening group,honeycomb lung group,lobular interval thickening group and non-ILD group were lower than those in ground-glass opacity group(P<0.05 to P<0.01).The C3 indexes in irregular line group or subpleural group and real shadow group were higher than those in non-ILD group(P<0.05 to P<0.01).In addition to the pulmonary bullae group,the C4 index in other groups were significantly lower than those in ground-glass opacity group(P<0.01).Conclusions:Different CTD complicated with ILD have different imaging features,inflammation indexes and complement levels.The early lung HRCT examination is helpful to the early diagnosis of ILD,and predict the prognosis.
2018, 43(3): 379-382.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.029
Abstract:
Objective:To investigate the correlations between different periods of women's menstrual cycle and clinical characteristics(breast symptom,hormone level and ultrasonic image).Methods:The breast pain sign,levels of serum estradiol(E2) and progesterone(P),and thickness of mammary gland,duct width,glandular structure and ADC detected by breast ultrasonography and MRI in 35 childbearing age women between 6 to 14 days of menstrualcycle(follicular phase) and 15 to 28 days menstrual cycle(luteal phase) were compared.Results:The levels of E2,P,LH and ADC value in luteal phase were higher than those in follicular phase(P<0.05),and the width of duct in luteal phase was significant lower than that in follicular phase(P<0.05).The levels of E2 and P at luteal and follicular phase were significantly related to the ADC value(P<0.05).In luteal phase,the levels of E2 and P in the women with breast structure change and pain decreased and increased compared with the women without breast structure change and pain,respectively(P<0.05 to P<0.01).In follicular phase,the level of P in the women with breast structure change was significant higher than that in women without breast structure change(P<0.01),and the levels of E2 and P in the women with breast tenderness were higher than those in women without breast tenderness(P<0.05 to P<0.01).Conclusions:With the change of the phase in menstrual cycle,the levels of E2 and P,and breast structure change.The breast tenderness is related to the levels of E2 and P,and the ADC value is closely related to the levels of E2 and P in different menstrual cycle.
Objective:To investigate the correlations between different periods of women's menstrual cycle and clinical characteristics(breast symptom,hormone level and ultrasonic image).Methods:The breast pain sign,levels of serum estradiol(E2) and progesterone(P),and thickness of mammary gland,duct width,glandular structure and ADC detected by breast ultrasonography and MRI in 35 childbearing age women between 6 to 14 days of menstrualcycle(follicular phase) and 15 to 28 days menstrual cycle(luteal phase) were compared.Results:The levels of E2,P,LH and ADC value in luteal phase were higher than those in follicular phase(P<0.05),and the width of duct in luteal phase was significant lower than that in follicular phase(P<0.05).The levels of E2 and P at luteal and follicular phase were significantly related to the ADC value(P<0.05).In luteal phase,the levels of E2 and P in the women with breast structure change and pain decreased and increased compared with the women without breast structure change and pain,respectively(P<0.05 to P<0.01).In follicular phase,the level of P in the women with breast structure change was significant higher than that in women without breast structure change(P<0.01),and the levels of E2 and P in the women with breast tenderness were higher than those in women without breast tenderness(P<0.05 to P<0.01).Conclusions:With the change of the phase in menstrual cycle,the levels of E2 and P,and breast structure change.The breast tenderness is related to the levels of E2 and P,and the ADC value is closely related to the levels of E2 and P in different menstrual cycle.
2018, 43(3): 385-387.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.031
Abstract:
Objective:To detect the common gene mutation site of deafness in north area of Anhui,and analyze the genetic etiology of deafness.Methods:The common nine gene mutation sites of GJB2,SLC26A4,mtDNA12SrRNA and GJB3 in 189 patients with deafness were detected,the correlation of which with deafness was analyzed.Results:Among 189 patients,the gene mutation sites in 27 cases caused by other diseases and 29 patients with sudden deafness were not detected.Among 133 patients with non-syndromic hearing loss(NSHL),the gene mutation sites in 55 cases(41.35%) were identified,the most common mutation genes were the GJB2(24.81%),SLC26A4(12.03%) and mtDNA12SrRNA(6.02%) in turn.The most common mutation sites were 235delC,IVS7-2A>G and 1555A>G,and the mutation rates of alleles of whose were 35.45%,20.00% and 11.82%,respectively.Conclusions:In NSHL patients from north area of Anhui,the most common mutation gene of deafness is GJB2,and the most common mutation site is 235delC.
Objective:To detect the common gene mutation site of deafness in north area of Anhui,and analyze the genetic etiology of deafness.Methods:The common nine gene mutation sites of GJB2,SLC26A4,mtDNA12SrRNA and GJB3 in 189 patients with deafness were detected,the correlation of which with deafness was analyzed.Results:Among 189 patients,the gene mutation sites in 27 cases caused by other diseases and 29 patients with sudden deafness were not detected.Among 133 patients with non-syndromic hearing loss(NSHL),the gene mutation sites in 55 cases(41.35%) were identified,the most common mutation genes were the GJB2(24.81%),SLC26A4(12.03%) and mtDNA12SrRNA(6.02%) in turn.The most common mutation sites were 235delC,IVS7-2A>G and 1555A>G,and the mutation rates of alleles of whose were 35.45%,20.00% and 11.82%,respectively.Conclusions:In NSHL patients from north area of Anhui,the most common mutation gene of deafness is GJB2,and the most common mutation site is 235delC.
2018, 43(3): 388-390.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.032
Abstract:
Objective:To explore the changes of hemorheology and coagulation fibrinolysis function in acute episode chronic occlusive pulmonary disease(AECOPD) patients complicated with diabetes mellitus.Methods:Fifty-two AECOPD patients complicated with diabetes mellitus,50 AECOPD patients and 40 healthy people were divided into the observation group,control group and normal group,respectively.The hemorheology indexes,four routine coagulation indexes,antithrombin-Ⅲ(AT-Ⅲ),D dimer(D-D) and fibrinogen degradation products(FDP) in three groups were detected.Results:The levels of whole blood viscosity,plasm viscosity,hematocrit and erythrocyte sedimentation rate in control group and observation group were significantly higher than those in normal group(P<0.01).The hemorheology indexes in observation group were significantly higher than that in control group(P<0.01).The coagulase coagulation time,prothrombin time and partial thrombin time in control group and observation group were significantly less than those in normal group(P<0.01),and the levels of fibrinogen,D-D and FDP in observation group were significantly higher than those in control group(P<0.01),and the coagulase coagulation time in observation group was significantly less than that in normal group(P<0.05).Conclusions:The hemorheology,and coagulation fibrinolysis function in AECOPD patients complicated with diabetes mellitus are obviously abnormal.
Objective:To explore the changes of hemorheology and coagulation fibrinolysis function in acute episode chronic occlusive pulmonary disease(AECOPD) patients complicated with diabetes mellitus.Methods:Fifty-two AECOPD patients complicated with diabetes mellitus,50 AECOPD patients and 40 healthy people were divided into the observation group,control group and normal group,respectively.The hemorheology indexes,four routine coagulation indexes,antithrombin-Ⅲ(AT-Ⅲ),D dimer(D-D) and fibrinogen degradation products(FDP) in three groups were detected.Results:The levels of whole blood viscosity,plasm viscosity,hematocrit and erythrocyte sedimentation rate in control group and observation group were significantly higher than those in normal group(P<0.01).The hemorheology indexes in observation group were significantly higher than that in control group(P<0.01).The coagulase coagulation time,prothrombin time and partial thrombin time in control group and observation group were significantly less than those in normal group(P<0.01),and the levels of fibrinogen,D-D and FDP in observation group were significantly higher than those in control group(P<0.01),and the coagulase coagulation time in observation group was significantly less than that in normal group(P<0.05).Conclusions:The hemorheology,and coagulation fibrinolysis function in AECOPD patients complicated with diabetes mellitus are obviously abnormal.
2018, 43(3): 391-393.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.033
Abstract:
Objective:To investigate the value of the detection of serum carbohydrate antigen(CA) 153 and carcinoembryonic antigen(CEA) combined with fine needle aspiration cytology(FNAC) in the diagnosis of breast cancer.Methods:The serum levels of CA153,CEA,and FNAC in 67 patients with breast cancer and 32 patients with benign breast disease were detected.The values of the combined detection of CA 153,CEA and FNAC in the diagnosis of breast cancer were analyzed.Results:The sensitivity,specificity and accuracy of CA153 examination were 8.96%,100.00% and 38.38%,respectively.The sensitivity,specificity and accuracy of CEA examination was 16.42%,96.88% and 43.43%,respectively.The sensitivity,specificity and accuracy of FNAC examination were 83.58%,100.00%and 88.89%,respectively.The sensitivity,specificity and accuracy of three combined inspection were 88.06%,90.91% and 96.88%,respectively.The AUC values of CA 153,CEA and FNAC in the diagnosis of breast cancer were 0.910,0.709 and 0.705,respectively,and the AUC value of combined detection(0.942) was significantly higher than that of any signal marker.Conclusions:The combined detection of CA153,CEA and FNAC can improve the sensitivity and accuracy in the diagnosis of breast cancer,which has a high reference value in the early diagnosis of breast cancer.
Objective:To investigate the value of the detection of serum carbohydrate antigen(CA) 153 and carcinoembryonic antigen(CEA) combined with fine needle aspiration cytology(FNAC) in the diagnosis of breast cancer.Methods:The serum levels of CA153,CEA,and FNAC in 67 patients with breast cancer and 32 patients with benign breast disease were detected.The values of the combined detection of CA 153,CEA and FNAC in the diagnosis of breast cancer were analyzed.Results:The sensitivity,specificity and accuracy of CA153 examination were 8.96%,100.00% and 38.38%,respectively.The sensitivity,specificity and accuracy of CEA examination was 16.42%,96.88% and 43.43%,respectively.The sensitivity,specificity and accuracy of FNAC examination were 83.58%,100.00%and 88.89%,respectively.The sensitivity,specificity and accuracy of three combined inspection were 88.06%,90.91% and 96.88%,respectively.The AUC values of CA 153,CEA and FNAC in the diagnosis of breast cancer were 0.910,0.709 and 0.705,respectively,and the AUC value of combined detection(0.942) was significantly higher than that of any signal marker.Conclusions:The combined detection of CA153,CEA and FNAC can improve the sensitivity and accuracy in the diagnosis of breast cancer,which has a high reference value in the early diagnosis of breast cancer.
2018, 43(3): 394-396.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.034
Abstract:
Objective:To explore the effects of electronic simplified Caprini risk assessment in the prevention of deep venous thrombosis(DVT) in ICU patients.Methods:According to the Chinese medical association thromboembolic disease prevention and control committee suggestion and ACCP-9(American College of Chest Physicians) guideline,the electronic bleeding risk assessment table and electronic simplified Caprini risk assessment table were designed and applied in the hospital electronic medical records information system.Fifty patients in ICU from September 2014 to June 2015 were assessed using the electronic bleeding risk assessment table and electronic simplified Caprini risk assessment table,and the DVT was prevented according to the assessment results.The DVT prevention data of 50 ICU patients without assessment from September 2013 to Septenber 2014 were retrospectively analyzed.Results:The prevention rate of DVT in ICU critical patients assessed by electronic simplified Caprini risk assessment was 100%,the physical prevention rate increased from 20% to 76%,the prevention rate of drug was similar to the combination prevention,and the difference of the prevention rate of DVT between assessment group and non-assessment group was statistically significant(P<0.01).Two cases in 50 cases before assessment died suddenly,and none in 50 cases after assessment died suddenly.Conclusions:The electronic simplified Caprini risk assessment based on evidence can increase the prevention rate of DVT in ICU patients,the quality of which still need to be continuously improved to improve the quality of medical care.
Objective:To explore the effects of electronic simplified Caprini risk assessment in the prevention of deep venous thrombosis(DVT) in ICU patients.Methods:According to the Chinese medical association thromboembolic disease prevention and control committee suggestion and ACCP-9(American College of Chest Physicians) guideline,the electronic bleeding risk assessment table and electronic simplified Caprini risk assessment table were designed and applied in the hospital electronic medical records information system.Fifty patients in ICU from September 2014 to June 2015 were assessed using the electronic bleeding risk assessment table and electronic simplified Caprini risk assessment table,and the DVT was prevented according to the assessment results.The DVT prevention data of 50 ICU patients without assessment from September 2013 to Septenber 2014 were retrospectively analyzed.Results:The prevention rate of DVT in ICU critical patients assessed by electronic simplified Caprini risk assessment was 100%,the physical prevention rate increased from 20% to 76%,the prevention rate of drug was similar to the combination prevention,and the difference of the prevention rate of DVT between assessment group and non-assessment group was statistically significant(P<0.01).Two cases in 50 cases before assessment died suddenly,and none in 50 cases after assessment died suddenly.Conclusions:The electronic simplified Caprini risk assessment based on evidence can increase the prevention rate of DVT in ICU patients,the quality of which still need to be continuously improved to improve the quality of medical care.
2018, 43(3): 397-399.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.035
Abstract:
Objective:To explore the effects of continual nursing based on network platform on the psychological status,self-efficacy and quality of life of patients with lung cancer.Methods:One hundred and twenty patients treated with radical mastectomy were divided into the observation group(n=60) and control group(n=60) according to the random number table.The control group were taught using conventional heath knowledge,and the observation group were additionally treated with continuous nursing based on the network platform at discharge.The psychological status,self-efficacy and quality of life in two groups between before and after 3 months of intervention were compared.Results:Before intervention,the differences of psychological status,self-efficacy and quality of life between two groups were not statistically significant(P>0.05).After intervention,the scores of hamilton depression rating scale and hamilton anxiety scale in observation group were significantly lower than those in control group(P<0.01).the score of self-efficacy in observation group was significantly higher than that in control group(P<0.01),and the scores of physiological function,emotional function,role function,cognitive function,social function and total health status in observation group were significantly higher than those in control group(P<0.01).Conclusions:The continual nursing based on network platform can effectively relieve the mental state of anxiety and depression,and improve the self-efficacy and quality of life of lung cancer patients after discharge.
Objective:To explore the effects of continual nursing based on network platform on the psychological status,self-efficacy and quality of life of patients with lung cancer.Methods:One hundred and twenty patients treated with radical mastectomy were divided into the observation group(n=60) and control group(n=60) according to the random number table.The control group were taught using conventional heath knowledge,and the observation group were additionally treated with continuous nursing based on the network platform at discharge.The psychological status,self-efficacy and quality of life in two groups between before and after 3 months of intervention were compared.Results:Before intervention,the differences of psychological status,self-efficacy and quality of life between two groups were not statistically significant(P>0.05).After intervention,the scores of hamilton depression rating scale and hamilton anxiety scale in observation group were significantly lower than those in control group(P<0.01).the score of self-efficacy in observation group was significantly higher than that in control group(P<0.01),and the scores of physiological function,emotional function,role function,cognitive function,social function and total health status in observation group were significantly higher than those in control group(P<0.01).Conclusions:The continual nursing based on network platform can effectively relieve the mental state of anxiety and depression,and improve the self-efficacy and quality of life of lung cancer patients after discharge.
2018, 43(3): 404-406.
doi: 10.13898/j.cnki.issn.1000-2200.2018.03.037
Abstract:
Objective:To compare the clinical efficacy of hemoperfusion at early or late stage during the hemodialysis combined with hemoperfusion treatment.Methods:A total of 106 uremia patients who were treated by combination of hemodialysis and hemoperfusion were included and randomly divided into group A and group B(53 cases each group).Blood perfusion was added 2 hours before dialysis in group A, while blood perfusion was added at last 2 hours of dialysis in group B.Three months after treatment, the levels of parathormone(PTH),blood urea nitrogen(BUN),creatinine(Cr),β2-microglobulin (β2-MG) between two groups were compared.The changes of the sleep situation,blood pressure,appetite,skin itching,body pain,numbness and restless leg syndrome before and after treatment were also observed.Results:The levels of BUN,PTH, Cr and β2-MG in two groups significantly decreased after treatment(P<0.05 to P<0.01),while the decreasing degree of these indexes in group B was more than that in group A(P<0.01).After treatment, the sleep disorder, high blood pressure and toe pain in two groups significantly improved(P<0.05 to P<0.01),while the poor appetite in two groups did not improve significantly(P>0.05).The sensory disorder and numbness improved only in group B(P<0.01).Conclusions:The combination of hemoperfusion at late stage of dialysis can significantly increase the clear rate of serum harmful substance, and improve the sensory disorder and numbness symptom.
Objective:To compare the clinical efficacy of hemoperfusion at early or late stage during the hemodialysis combined with hemoperfusion treatment.Methods:A total of 106 uremia patients who were treated by combination of hemodialysis and hemoperfusion were included and randomly divided into group A and group B(53 cases each group).Blood perfusion was added 2 hours before dialysis in group A, while blood perfusion was added at last 2 hours of dialysis in group B.Three months after treatment, the levels of parathormone(PTH),blood urea nitrogen(BUN),creatinine(Cr),β2-microglobulin (β2-MG) between two groups were compared.The changes of the sleep situation,blood pressure,appetite,skin itching,body pain,numbness and restless leg syndrome before and after treatment were also observed.Results:The levels of BUN,PTH, Cr and β2-MG in two groups significantly decreased after treatment(P<0.05 to P<0.01),while the decreasing degree of these indexes in group B was more than that in group A(P<0.01).After treatment, the sleep disorder, high blood pressure and toe pain in two groups significantly improved(P<0.05 to P<0.01),while the poor appetite in two groups did not improve significantly(P>0.05).The sensory disorder and numbness improved only in group B(P<0.01).Conclusions:The combination of hemoperfusion at late stage of dialysis can significantly increase the clear rate of serum harmful substance, and improve the sensory disorder and numbness symptom.
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