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2018 Vol. 43, No. 4
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2018, 43(4): 421-424.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.001
Abstract:
Objective:To establish a three-dimensional visualization model of the cerebral planum temporale using live MR images of healthy adults,and explore the anatomical features of the planum temporale.Methods:The slice MR scan data of a healthy male adult brain were imported into the Able Software 3D-Doctor,the three-dimensional visualization model was established using manual segmentation method,and the related structure was labeled using different colors.Results:A three-dimensional visualization model of the cerebral planum temporale was successfully constructed,which could successfully display the three-dimensional morphology of the planum temporale,lateral ventricle and brain surface,and the structural relationship with the surrounding brain tissue.Conclusions:The establishment of three-dimensional visualization model of the cerebral planum temporale has great value in the recognition of anatomical structures of the planum temporale,and design of stereotactic surgery.
Objective:To establish a three-dimensional visualization model of the cerebral planum temporale using live MR images of healthy adults,and explore the anatomical features of the planum temporale.Methods:The slice MR scan data of a healthy male adult brain were imported into the Able Software 3D-Doctor,the three-dimensional visualization model was established using manual segmentation method,and the related structure was labeled using different colors.Results:A three-dimensional visualization model of the cerebral planum temporale was successfully constructed,which could successfully display the three-dimensional morphology of the planum temporale,lateral ventricle and brain surface,and the structural relationship with the surrounding brain tissue.Conclusions:The establishment of three-dimensional visualization model of the cerebral planum temporale has great value in the recognition of anatomical structures of the planum temporale,and design of stereotactic surgery.
2018, 43(4): 425-428.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.002
Abstract:
Objective:To investigate the differences of the brain in different sides and genders.Methods:The images of transection plane,sagittal plane and coronal plane of brain in 42 right-hand people were investigated using MRI thin layer scanning.The central sulcus and postcentral gyrus were identified using the MRI,and the morphological characteristics of which was observed.Results:The results of MRI showed that the left anterior wall of postcentral gyrus in female was closer to the middle line,the right side anterior wall of postcentral gyrus in male was away from the middle line,the left side anterior wall of postcentral gyrus in male was closer to the front,and the height of anterior wall of postcentral gyrus in male was higher than that in female.Conclusions:The differences of the morphology of the central sulcus in different sides and genders may be related to the difference of brain function in different genders.
Objective:To investigate the differences of the brain in different sides and genders.Methods:The images of transection plane,sagittal plane and coronal plane of brain in 42 right-hand people were investigated using MRI thin layer scanning.The central sulcus and postcentral gyrus were identified using the MRI,and the morphological characteristics of which was observed.Results:The results of MRI showed that the left anterior wall of postcentral gyrus in female was closer to the middle line,the right side anterior wall of postcentral gyrus in male was away from the middle line,the left side anterior wall of postcentral gyrus in male was closer to the front,and the height of anterior wall of postcentral gyrus in male was higher than that in female.Conclusions:The differences of the morphology of the central sulcus in different sides and genders may be related to the difference of brain function in different genders.
2018, 43(4): 429-432,436.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.003
Abstract:
Objective:To investigate the of dual-phase enhanced scanning technology in pulmonary angiography(PA) and bronchial angiography(BA).Methods:One hundred and twenty scanned by chest enhanced 64-slice spiral CT from the Second Affiliated Hospital of Suzhou University were selected.The fixed delay method and bolus tracking(BT) method were employed.The patients treated with fixed delay method were divided into the group A(injected with 80mL contrast agent,delay scanning for 14 s in PA phase and delay scanning for 20s in BA phase),groupB(injected with 80mL contrast agent,delay scanning for 14s in PA phase and delay scanning for 22s in BA phase),and group C(injected with 70mL contrast agent,delay scanning for 12s in PA phase and delay scanning for 22s in BA phase).Among the patients treated with Bolus Tracking(BT),the same slice was tracked and scanned after 3s of 70mL contrast agent injecting.The crotch of the pulmonary artery trunk was the interest region,the scan was launched after the CT value achieved 100Hu threshold.The target vascular enhancement value was evaluated,and the difference of which was compared.Results:Among the patients treated with fixed delay method,the reinforced difference values of PA/DA in PA phase and BA phase in group C were(243±111)Hu and(248±73)Hu,respectively,and the difference of the density in group C was significantly higher than that in group A and group B.In PA phase,the difference value of PA/DA in group C was higher than that in group A and group B(P<0.05 and P<0.01),the CT values of superior vena cava(SVC) in group B and group C were higher than that in group A(P<0.05 and P<0.01),the CT values of ascending aorta(AA) and descending aorta(DA) in group C were significantly lower than those in group A and group B(P<0.05 to P<0.01),and the CT value of left atrium(LV) was lower than that in group A and group B(P<0.05).In BA phase,the differences of the CT values of SVC,PA,LV and AA between group A and group B were statistically significant(P<0.05),the CT values of SVC,LV and AA in group C were significantly lower than those in group A and group B(P<0.05 to P<0.01),the differences of the CT values of SVC,LV and AA between groups A and B were not statistically signficant(P>0.05),and the contrast agent in group C decreased.Among the patients treated with bolus tracking(BT) method,the reinforced difference values of PA/DA in PA phase and BA phase in group C were (241±97)Hu and (234±60)Hu,respectively,and the difference of which between two methods was not statistically significant(P>0.05).Conclusions:The good images of CTPA and CTBA can be acquired using the fixed delay method or bolus tracking method at one check,and the fixed delay method or bolus tracking method is a two-phase imaging technology,which can identify the density difference of PA and BA.The bolus tracking method has advantage over the fixed delay method in individualized examination.
Objective:To investigate the of dual-phase enhanced scanning technology in pulmonary angiography(PA) and bronchial angiography(BA).Methods:One hundred and twenty scanned by chest enhanced 64-slice spiral CT from the Second Affiliated Hospital of Suzhou University were selected.The fixed delay method and bolus tracking(BT) method were employed.The patients treated with fixed delay method were divided into the group A(injected with 80mL contrast agent,delay scanning for 14 s in PA phase and delay scanning for 20s in BA phase),groupB(injected with 80mL contrast agent,delay scanning for 14s in PA phase and delay scanning for 22s in BA phase),and group C(injected with 70mL contrast agent,delay scanning for 12s in PA phase and delay scanning for 22s in BA phase).Among the patients treated with Bolus Tracking(BT),the same slice was tracked and scanned after 3s of 70mL contrast agent injecting.The crotch of the pulmonary artery trunk was the interest region,the scan was launched after the CT value achieved 100Hu threshold.The target vascular enhancement value was evaluated,and the difference of which was compared.Results:Among the patients treated with fixed delay method,the reinforced difference values of PA/DA in PA phase and BA phase in group C were(243±111)Hu and(248±73)Hu,respectively,and the difference of the density in group C was significantly higher than that in group A and group B.In PA phase,the difference value of PA/DA in group C was higher than that in group A and group B(P<0.05 and P<0.01),the CT values of superior vena cava(SVC) in group B and group C were higher than that in group A(P<0.05 and P<0.01),the CT values of ascending aorta(AA) and descending aorta(DA) in group C were significantly lower than those in group A and group B(P<0.05 to P<0.01),and the CT value of left atrium(LV) was lower than that in group A and group B(P<0.05).In BA phase,the differences of the CT values of SVC,PA,LV and AA between group A and group B were statistically significant(P<0.05),the CT values of SVC,LV and AA in group C were significantly lower than those in group A and group B(P<0.05 to P<0.01),the differences of the CT values of SVC,LV and AA between groups A and B were not statistically signficant(P>0.05),and the contrast agent in group C decreased.Among the patients treated with bolus tracking(BT) method,the reinforced difference values of PA/DA in PA phase and BA phase in group C were (241±97)Hu and (234±60)Hu,respectively,and the difference of which between two methods was not statistically significant(P>0.05).Conclusions:The good images of CTPA and CTBA can be acquired using the fixed delay method or bolus tracking method at one check,and the fixed delay method or bolus tracking method is a two-phase imaging technology,which can identify the density difference of PA and BA.The bolus tracking method has advantage over the fixed delay method in individualized examination.
2018, 43(4): 433-436.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.004
Abstract:
Objective:To detect the gender differences of left ventricular morphology and function in young people using 2D-echocardiography and cardiac magnetic resonance (CMR),and compare the application value of the two methods.Methods:Fifteen male college students and 15 female college students were divided into two groups according to the gender.The left ventricular end-diastolic volume (EDV),end-systolic Volume(ESV),ejection fraction(EF),stroke volume(SV) and fractional shortening (FS) were detected using 2D-echocardiography and CMR,respectively.Results:The results of 2D-echocardiography and CMR showed that the left ventricular EDV in male group was higher than that in female group(P<0.05),and the differences of ESV,SV and EV between two groups were not statistically significant(P>0.05) after BSA calibration.The statistical results of the left ventricular EF,EVD and ESV values were positively correlated with the two imaging methods(P<0.01).Bland-Altman analysis showed that the left ventricular EVD,ESV and SV detected by 2D-echocardiography were lower than those by CMR.Conclusions:The left ventricular morphology and function in different gender young people are different.The value between 2D-echocardiography and CMR in the diagnosis of left ventricular morphology and function is similar,but which is not equivalent.
Objective:To detect the gender differences of left ventricular morphology and function in young people using 2D-echocardiography and cardiac magnetic resonance (CMR),and compare the application value of the two methods.Methods:Fifteen male college students and 15 female college students were divided into two groups according to the gender.The left ventricular end-diastolic volume (EDV),end-systolic Volume(ESV),ejection fraction(EF),stroke volume(SV) and fractional shortening (FS) were detected using 2D-echocardiography and CMR,respectively.Results:The results of 2D-echocardiography and CMR showed that the left ventricular EDV in male group was higher than that in female group(P<0.05),and the differences of ESV,SV and EV between two groups were not statistically significant(P>0.05) after BSA calibration.The statistical results of the left ventricular EF,EVD and ESV values were positively correlated with the two imaging methods(P<0.01).Bland-Altman analysis showed that the left ventricular EVD,ESV and SV detected by 2D-echocardiography were lower than those by CMR.Conclusions:The left ventricular morphology and function in different gender young people are different.The value between 2D-echocardiography and CMR in the diagnosis of left ventricular morphology and function is similar,but which is not equivalent.
2018, 43(4): 437-439,443.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.005
Abstract:
Objective:To explore the effects of emergency percutaneous coronary intervention(PCI) and selective PCI on left ventricular function and prognosis of patients with acute myocardial infarction(AMI).Methods:The first AMI 43 patients treated without vein thrombolysis were selected,29 patients were treated with emergency PCI(emergency group),and 14 cases were treated with selective PCI(selective group).All patients were examined using transthoracic echocardiography(TTE) before PCI,and after 1 and 3 months of PCI,and the levels of left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV) and left ventricular ejection fraction(LVEF) were measured in wo groups.Results:The success rates of operation in two groups were 100%.The stent was implanted into the stenosis location of coronary artery in patients treated with PCI,and the success rate of stent implanting was 100%.Compared before operation,the levels of LVEDD,LVESD,LVEDV and LVESV decreased,and the level of LVEF significantly increased in emergency group after 1 and 3 months of operation(P<0.05 to P<0.01).Compared before operation,the levels of LVEDD,LVEDV and LVESV decreased(P<0.05 to P<0.01),the level change of LVESD was not obvious(P>0.05),and the level of LVEF significantly increased in selective group after 1 and 3 months of operation(P<0.01).The differences of the levels of LVEDD,LVESD,LVEDV and LVESV between two groups before operation were not statistically significant(P>0.05),and the levels of LVEDD,LVESD,LVEDV and LVESV in emergency group were lower than those in selective group after operation(P<0.05).Conclusions:Emergency PCI can improve the reconstruction of left ventricular,and inhibit the left ventricular systolic function in AMI patients.The treatment effect of emergency PCI on AMI is significant.
Objective:To explore the effects of emergency percutaneous coronary intervention(PCI) and selective PCI on left ventricular function and prognosis of patients with acute myocardial infarction(AMI).Methods:The first AMI 43 patients treated without vein thrombolysis were selected,29 patients were treated with emergency PCI(emergency group),and 14 cases were treated with selective PCI(selective group).All patients were examined using transthoracic echocardiography(TTE) before PCI,and after 1 and 3 months of PCI,and the levels of left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV) and left ventricular ejection fraction(LVEF) were measured in wo groups.Results:The success rates of operation in two groups were 100%.The stent was implanted into the stenosis location of coronary artery in patients treated with PCI,and the success rate of stent implanting was 100%.Compared before operation,the levels of LVEDD,LVESD,LVEDV and LVESV decreased,and the level of LVEF significantly increased in emergency group after 1 and 3 months of operation(P<0.05 to P<0.01).Compared before operation,the levels of LVEDD,LVEDV and LVESV decreased(P<0.05 to P<0.01),the level change of LVESD was not obvious(P>0.05),and the level of LVEF significantly increased in selective group after 1 and 3 months of operation(P<0.01).The differences of the levels of LVEDD,LVESD,LVEDV and LVESV between two groups before operation were not statistically significant(P>0.05),and the levels of LVEDD,LVESD,LVEDV and LVESV in emergency group were lower than those in selective group after operation(P<0.05).Conclusions:Emergency PCI can improve the reconstruction of left ventricular,and inhibit the left ventricular systolic function in AMI patients.The treatment effect of emergency PCI on AMI is significant.
2018, 43(4): 440-443.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.006
Abstract:
Objective:To study the anatomy and variation of renal artery using the multislice spiral CT angiography(MSCTA) three-dimensional reconstruction imaging technigue for providing the anatomical reference in renal surgery.Methods:The imaging data of 50 patients detected by renal artery MSCTA examination were retrospectively analyzed.The relationship between the origin position of renal artery and vertebral body was observed,the included angle between left and right renal artery with abdominal aorta was compared,and the renal artery variation was observed.Results:The 97% renal artery open located at 1/3 above the first lumbar vertebral body to 1/3 below the second lumbar vertebra.The diameter of the main renal artery complicated with the auxiliary renal artery was less than that of the single renal artery(P<0.01).The left side θ angle was larger than the right side θ angle(P<0.01).Among 50 cases,24(48%) cases with renal artery variation were identified,and the renal artery variation between left and right sides was similar.Among 32 cases with renal artery variation,23 cases were origin from abdominal aorta,and 9 cases were origin from renal artery.Conclusions:The anatomy of renal artery can be stereoscopically and intuitively observed by MSCTA,and the imaging findings can provide anatomic reference in related renal operation.
Objective:To study the anatomy and variation of renal artery using the multislice spiral CT angiography(MSCTA) three-dimensional reconstruction imaging technigue for providing the anatomical reference in renal surgery.Methods:The imaging data of 50 patients detected by renal artery MSCTA examination were retrospectively analyzed.The relationship between the origin position of renal artery and vertebral body was observed,the included angle between left and right renal artery with abdominal aorta was compared,and the renal artery variation was observed.Results:The 97% renal artery open located at 1/3 above the first lumbar vertebral body to 1/3 below the second lumbar vertebra.The diameter of the main renal artery complicated with the auxiliary renal artery was less than that of the single renal artery(P<0.01).The left side θ angle was larger than the right side θ angle(P<0.01).Among 50 cases,24(48%) cases with renal artery variation were identified,and the renal artery variation between left and right sides was similar.Among 32 cases with renal artery variation,23 cases were origin from abdominal aorta,and 9 cases were origin from renal artery.Conclusions:The anatomy of renal artery can be stereoscopically and intuitively observed by MSCTA,and the imaging findings can provide anatomic reference in related renal operation.
2018, 43(4): 444-449.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.007
Abstract:
Objective:To investigate the effects of docosahexaenoic acid(DHA) on the atrial fibrosis in atrial fibrillation rats,and mRNA and protein levels of extracellular signal-regulated kinase 1/2(ERK1/2),phosphorylated extracellular signal-regulated kinase 1/2(p-ERK1/2) and type Ⅰ collagen.Methods:Eighty Sprague-Dawley (SD) rats sensitive to acetylcholine-calcium chloride mixture were randomly divided into the control group(CTL group),control treated with DHA group(DHA group),atrial fibrillation group(AF group) and atrial fibrillation treated with DHA group(DHA+AF group) (20 rats each group).The duration of atrial fibrillation in each group was measured.The atrial collagen fiber hyperplasia in rats were detected using Masson staining.The mRNA expression of type Ⅰ collagen in atrial tissue was detected using the quantitative real-time PCR,and the protein levels of ERK1/2,p-ERK1/2 and type Ⅰcollagen in atrial tissue were detected by Western blot.Results:At 10 and 17 days of experiment,the duration of atrial fibrillation in (DHA+AF) group was significantly shorter than that in AF group(P<0.01).Compared with the CTL group,a lot of collagen fibers proliferation in atrial interstitium were found,and the interstitial fibrosis in atrial was higher in AF group.Compared with the AF group, a little collagen fibers proliferation in atrial interstitium was found,and the interstitial fibrosis in atrial was lower in (DHA+AF) group.Compared with the CTL group,the ratio of p-ERK1/2 to ERK1/2 increased in AF group(P<0.05),which in DHA group decreased(P<0.05),and the difference of which between CTL group and(DHA+AF) group was not statistically significant(P>0.05).Compared with the AF group,the ratio of p-ERK1/2 to ERK1/2 decreased in (DHA+AF) group(P<0.05).Compared with the CTL group,the mRNA and protein levels of type Ⅰ collagen in atrial tissue increased in AF group and (DHA+AF) group(P<0.05 to P<0.01).Compared with the AF group,the mRNA and protein levels of type Ⅰ collagen in atrial tissue decreased in(DHA+AF) group(P<0.05).Conclusions:DHA can improve the atrial fibrosis in atrial fibrillation rats,the mechanism of which may be related to the mRNA and protein expressions of type Ⅰcollagen down-regulating by inhibiting the ERK1/2 activation in atrial tissue.
Objective:To investigate the effects of docosahexaenoic acid(DHA) on the atrial fibrosis in atrial fibrillation rats,and mRNA and protein levels of extracellular signal-regulated kinase 1/2(ERK1/2),phosphorylated extracellular signal-regulated kinase 1/2(p-ERK1/2) and type Ⅰ collagen.Methods:Eighty Sprague-Dawley (SD) rats sensitive to acetylcholine-calcium chloride mixture were randomly divided into the control group(CTL group),control treated with DHA group(DHA group),atrial fibrillation group(AF group) and atrial fibrillation treated with DHA group(DHA+AF group) (20 rats each group).The duration of atrial fibrillation in each group was measured.The atrial collagen fiber hyperplasia in rats were detected using Masson staining.The mRNA expression of type Ⅰ collagen in atrial tissue was detected using the quantitative real-time PCR,and the protein levels of ERK1/2,p-ERK1/2 and type Ⅰcollagen in atrial tissue were detected by Western blot.Results:At 10 and 17 days of experiment,the duration of atrial fibrillation in (DHA+AF) group was significantly shorter than that in AF group(P<0.01).Compared with the CTL group,a lot of collagen fibers proliferation in atrial interstitium were found,and the interstitial fibrosis in atrial was higher in AF group.Compared with the AF group, a little collagen fibers proliferation in atrial interstitium was found,and the interstitial fibrosis in atrial was lower in (DHA+AF) group.Compared with the CTL group,the ratio of p-ERK1/2 to ERK1/2 increased in AF group(P<0.05),which in DHA group decreased(P<0.05),and the difference of which between CTL group and(DHA+AF) group was not statistically significant(P>0.05).Compared with the AF group,the ratio of p-ERK1/2 to ERK1/2 decreased in (DHA+AF) group(P<0.05).Compared with the CTL group,the mRNA and protein levels of type Ⅰ collagen in atrial tissue increased in AF group and (DHA+AF) group(P<0.05 to P<0.01).Compared with the AF group,the mRNA and protein levels of type Ⅰ collagen in atrial tissue decreased in(DHA+AF) group(P<0.05).Conclusions:DHA can improve the atrial fibrosis in atrial fibrillation rats,the mechanism of which may be related to the mRNA and protein expressions of type Ⅰcollagen down-regulating by inhibiting the ERK1/2 activation in atrial tissue.
2018, 43(4): 450-453.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.008
Abstract:
Objective:To evaluate the effects of the AMPK activator AICAR on the inflammatory response of astrocytes and protecting the neurons after oxygen-glucose deprivation OGD-treatment.Methods:The OGD-treated model in primary cultured neurons and astrocytes was established.AICAR(0.5 mmol/L) and control solution were added into the primary cultured astrocytes,then which was treated with OGD.After 12 h of reoxygenation,the expression levels of pro-inflammatory cytokines(TNF-α,IL-6 and IL-1β) were analyzed using ELISA,and the level of phosphorylated p38 was analyzed using Western blot.The astrocytic medium of control group and AICAR group treated with OGD were added into the primary cultured neurons injured by OGD.The neuroprotective effect of AICAR on the OGD-injured neurons was analyzed by LDH and immunofluoresent double staining.Results:In the OGD-treated primary cultured neurons and astrocytes,AICAR significantly reduced the levels of TNF-α,IL-6 and IL-1β secreted from OGD-treated astrocytes,inhibited the phosphorylation of p38,reduced the OGD-induced injury of neurons,and promoted the recovery of neurites compared with control group.Conclusions:AICAR can inhibit the secretion of inflammatory cytokines from OGD-treated astrocytes,and protect the OGD-treated neurons.
Objective:To evaluate the effects of the AMPK activator AICAR on the inflammatory response of astrocytes and protecting the neurons after oxygen-glucose deprivation OGD-treatment.Methods:The OGD-treated model in primary cultured neurons and astrocytes was established.AICAR(0.5 mmol/L) and control solution were added into the primary cultured astrocytes,then which was treated with OGD.After 12 h of reoxygenation,the expression levels of pro-inflammatory cytokines(TNF-α,IL-6 and IL-1β) were analyzed using ELISA,and the level of phosphorylated p38 was analyzed using Western blot.The astrocytic medium of control group and AICAR group treated with OGD were added into the primary cultured neurons injured by OGD.The neuroprotective effect of AICAR on the OGD-injured neurons was analyzed by LDH and immunofluoresent double staining.Results:In the OGD-treated primary cultured neurons and astrocytes,AICAR significantly reduced the levels of TNF-α,IL-6 and IL-1β secreted from OGD-treated astrocytes,inhibited the phosphorylation of p38,reduced the OGD-induced injury of neurons,and promoted the recovery of neurites compared with control group.Conclusions:AICAR can inhibit the secretion of inflammatory cytokines from OGD-treated astrocytes,and protect the OGD-treated neurons.
2018, 43(4): 454-458.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.009
Abstract:
Objective:To investigate the osteoconduction of the rabbit's allograft bone surface-modified by polylysine.Methods:The surface of the micropores of the rabbit allograft bone was modified with polylysine using the lyophilization method(experimenal group),and the un-modified surface of the micropores of the rabbit allograft bone was set as control group.The rabbits' BMSCs were implanted into the surface of the micropores of the allograft bone in two groups,cultured and induced to osteoblasts.The attachment and proliferation of the cells on the surface of the micropores in the allograft bone in two groups were detected using SEM and MTT method,respectively.The activity of the alkaline phosphatase in two groups were evaluated.The allograft bone complicated with autologous cell was implanted into the bilateral radiuses defect of rabbits.The specimens were reconstructed by spiral CT after 1,2,3 and 4 months of treatment,and the regenerated bone was observed.Results:The attachment,proliferation and expression of ALP in experimental group were obviously better than those in control group(P<0.01).The recovery of defect lesion in experimental group was better than that in control group(P<0.01).Conclusions:The osteoconduction of the allograft bone surface-modified by polylysine can be significantly strengthened in vivo and in vitro.
Objective:To investigate the osteoconduction of the rabbit's allograft bone surface-modified by polylysine.Methods:The surface of the micropores of the rabbit allograft bone was modified with polylysine using the lyophilization method(experimenal group),and the un-modified surface of the micropores of the rabbit allograft bone was set as control group.The rabbits' BMSCs were implanted into the surface of the micropores of the allograft bone in two groups,cultured and induced to osteoblasts.The attachment and proliferation of the cells on the surface of the micropores in the allograft bone in two groups were detected using SEM and MTT method,respectively.The activity of the alkaline phosphatase in two groups were evaluated.The allograft bone complicated with autologous cell was implanted into the bilateral radiuses defect of rabbits.The specimens were reconstructed by spiral CT after 1,2,3 and 4 months of treatment,and the regenerated bone was observed.Results:The attachment,proliferation and expression of ALP in experimental group were obviously better than those in control group(P<0.01).The recovery of defect lesion in experimental group was better than that in control group(P<0.01).Conclusions:The osteoconduction of the allograft bone surface-modified by polylysine can be significantly strengthened in vivo and in vitro.
2018, 43(4): 458-461.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.010
Abstract:
Objective:To explore the mRNA expressions of matrix metalloproteinases(MMPs) in rabbit articular chondrocytes at different time-points after injury.Methods:The rabbit knee joint cartilage cells were obtained under sterile condition,primarily cultured in vitro,and established the cell scratch model in six-well plates.The proliferation of chondrocytes after 1,3 and 7 days of scratching and normal cells were observed under the microscope.The MMPs mRNA expression levels in normal cells and different time-points after injury were detected using real-time PCR.Results:The articular chordrocyte was successfully isolated,the scratch model of chondrocytes was established after primary culture.Compared with normal cells,the mRNA expression levels of MMP-2 gene in chondrocytes increased at 1,3 and 7 days aftere injury,and which was the highest on the seventh day(P<0.05 to P<0.01).Compared with normal cells,the mRNA expression levels of MMP-3 gene in chondrocytes decreased significantly at 1,3 and 7 days after injury,and which was the lowest at on the seventh day(P<0.01).Compared with normal cells,the mRNA expression levels of MMP-9 gene in chondrocytes increased at 1,3 and 7 days after injury,and which was the highest on the third day and then began to decrease(P<0.01).Conclusions:The mRNA expression levels of MMPs are different after injury,which can provide the experimental evidence in gene therapy of articular cartilage injury.
Objective:To explore the mRNA expressions of matrix metalloproteinases(MMPs) in rabbit articular chondrocytes at different time-points after injury.Methods:The rabbit knee joint cartilage cells were obtained under sterile condition,primarily cultured in vitro,and established the cell scratch model in six-well plates.The proliferation of chondrocytes after 1,3 and 7 days of scratching and normal cells were observed under the microscope.The MMPs mRNA expression levels in normal cells and different time-points after injury were detected using real-time PCR.Results:The articular chordrocyte was successfully isolated,the scratch model of chondrocytes was established after primary culture.Compared with normal cells,the mRNA expression levels of MMP-2 gene in chondrocytes increased at 1,3 and 7 days aftere injury,and which was the highest on the seventh day(P<0.05 to P<0.01).Compared with normal cells,the mRNA expression levels of MMP-3 gene in chondrocytes decreased significantly at 1,3 and 7 days after injury,and which was the lowest at on the seventh day(P<0.01).Compared with normal cells,the mRNA expression levels of MMP-9 gene in chondrocytes increased at 1,3 and 7 days after injury,and which was the highest on the third day and then began to decrease(P<0.01).Conclusions:The mRNA expression levels of MMPs are different after injury,which can provide the experimental evidence in gene therapy of articular cartilage injury.
2018, 43(4): 462-467.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.011
Abstract:
Objective:To investigate human papillomavirus(HPV) infection in cervix uteri among 116 441 census women in Minhang District of Shanghai,analyze HPV genotype,characteristic of age distribution and distribution characteristic of HPV genotype in women with cervical lesion.Methods:HPV genotyping was performed by high throughput sequencing technology to test 14 high-risk types of HPV and 2 low-risk types of HPV.Results:A total number of 115 463 cases were successfully detected,the infection rate of HPV and high-risk HPV was 11.18% and 10.93%,respectively.The highest infection rate was 15.90% founded in ≤ 25 years old group.Multiple infections were mainly found in >60 years old women.The top five of infection rate in general population was HPV52,HPV58,HPV16,HPV68 and HPV18.The rate of multiple infections was 21.02%,there were six kinds of infections at most.There were 208 cases of cervical cancer and precancerous lesion,in which 97.60% with HPV infection.All of the cervical cancer and CINⅢ cases were infected by high-risk HPV,the top five of infection rate was HPV16,HPV52,HPV58,HPV18 and HPV31.HPV16 was the first one and the rate of infection improved with the increasing grade of cervical lesion.Conclusions:Continued infection by HPV16,HPV52,HPV58 and HPV18 is the leading cause of cervical precancerous lesion and cervical cancer in women in Minhang District.HPV16 has the strongest carcinogenicity.After gynecological census,close follow-up and management of HPV16,HPV52,HPV58 and HPV18 infection are needed,it is especially necessary to pay attention to elderly women with HPV16 multiple infections.
Objective:To investigate human papillomavirus(HPV) infection in cervix uteri among 116 441 census women in Minhang District of Shanghai,analyze HPV genotype,characteristic of age distribution and distribution characteristic of HPV genotype in women with cervical lesion.Methods:HPV genotyping was performed by high throughput sequencing technology to test 14 high-risk types of HPV and 2 low-risk types of HPV.Results:A total number of 115 463 cases were successfully detected,the infection rate of HPV and high-risk HPV was 11.18% and 10.93%,respectively.The highest infection rate was 15.90% founded in ≤ 25 years old group.Multiple infections were mainly found in >60 years old women.The top five of infection rate in general population was HPV52,HPV58,HPV16,HPV68 and HPV18.The rate of multiple infections was 21.02%,there were six kinds of infections at most.There were 208 cases of cervical cancer and precancerous lesion,in which 97.60% with HPV infection.All of the cervical cancer and CINⅢ cases were infected by high-risk HPV,the top five of infection rate was HPV16,HPV52,HPV58,HPV18 and HPV31.HPV16 was the first one and the rate of infection improved with the increasing grade of cervical lesion.Conclusions:Continued infection by HPV16,HPV52,HPV58 and HPV18 is the leading cause of cervical precancerous lesion and cervical cancer in women in Minhang District.HPV16 has the strongest carcinogenicity.After gynecological census,close follow-up and management of HPV16,HPV52,HPV58 and HPV18 infection are needed,it is especially necessary to pay attention to elderly women with HPV16 multiple infections.
2018, 43(4): 467-470.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.012
Abstract:
Objective:To investigate the expression levels of SRY-related HMG-box 4(Sox4) and epithelial-mesenchymal transition related protein E-cadherin in cervical squamous cell carcinoma(CSCC),and their clinical significance.Methods:The expression levels of Sox4 and E-cadherin proteins in CSCC group(160 cases) and control group(28 cases) were detected by S-P immunohistochemical method,and the relationships between which and clinicopathological parameters were analyzed.Results:The positive rate of Sox4 in observation group(63.75%) was higher than that in control group(39.29%)(P<0.05).The positive rate of E-cadherin in observation group(35%) was lower than that in control group(64.29%)(P<0.05).The expression level of Sox4 was negatively correlated with E-cadherin(P<0.01),closely related to the tumor diameter,lymph node metastasis,parametrial infiltration and FIGO stage(P<0.05 to P<0.01),and unrelated to the age of patients(P>0.05).Conclusions:Sox4 may promote the occurrence,development,invasion and metastasis of CSCC by down-regulating the E-cadherin protein.The combined detection of Sox4 and E-cadherin can provide the reference in early diagnosis,treatment and predicting the prognosis of patients with CSCC.
Objective:To investigate the expression levels of SRY-related HMG-box 4(Sox4) and epithelial-mesenchymal transition related protein E-cadherin in cervical squamous cell carcinoma(CSCC),and their clinical significance.Methods:The expression levels of Sox4 and E-cadherin proteins in CSCC group(160 cases) and control group(28 cases) were detected by S-P immunohistochemical method,and the relationships between which and clinicopathological parameters were analyzed.Results:The positive rate of Sox4 in observation group(63.75%) was higher than that in control group(39.29%)(P<0.05).The positive rate of E-cadherin in observation group(35%) was lower than that in control group(64.29%)(P<0.05).The expression level of Sox4 was negatively correlated with E-cadherin(P<0.01),closely related to the tumor diameter,lymph node metastasis,parametrial infiltration and FIGO stage(P<0.05 to P<0.01),and unrelated to the age of patients(P>0.05).Conclusions:Sox4 may promote the occurrence,development,invasion and metastasis of CSCC by down-regulating the E-cadherin protein.The combined detection of Sox4 and E-cadherin can provide the reference in early diagnosis,treatment and predicting the prognosis of patients with CSCC.
2018, 43(4): 471-474.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.013
Abstract:
Objective:To explore the effects of different degrees of acute hypervolumic hemodilution on the blood coagulation function and systemic inflammatory response in elderly patients.Methods:The clinical data of 156 patients treated with acute hypervolumic hemodilution were retrospectively analyzed.According to the different degree of dilution,the patients were divided into the 30% Hct group(group A) and 25% Hct group(group B).The blood coagulation function and systemic inflammatory reaction between two groups before operation(T0),after operation(T1) and at the end of operation(T2) were compared.Results:The hemoglobin level and platelet count in two groups at T2 significantly decreased compared with at T0(P<0.01),and the prothrombin time in two groups at T1 was significantly higher than that at T0 and T2(P<0.05 to P<0.01).The hemoglobin level in group B at T2 was significantly lower than that in group A(P<0.01),and the platelet count in group B at T1 and T2 were significantly lower than that in group A(P<0.01).The differences of prothrombin time and activated partial thromboplastin time between two groups at all time-points were not statistically significant(P>0.05).The levels of interleukin(IL)IL-1β,IL-6,atrial natriuretic polypeptide(ANP) in two groups at T1 and T2 were significantly higher than those at T0(P<0.05 to P<0.01),and the pulmonary compliance(CL) at T1 and T2 were significantly lower than that at T0(P<0.01).The levels of IL-1β and CL in group B at T1 and T2 were significantly lower than those in group A(P<0.01),and the level of ANP in group B at T2 was higher than that in group A(P<0.05).Conclusions:The effects of different degrees of acute hypervolumic hemodilution on the blood coagulation function and systemic inflammatory response in elderly patients are different.The low degree of dilution may affect the oxygenation,reduce the blood coagulation function,and aggravate the systemic inflammatory response.
Objective:To explore the effects of different degrees of acute hypervolumic hemodilution on the blood coagulation function and systemic inflammatory response in elderly patients.Methods:The clinical data of 156 patients treated with acute hypervolumic hemodilution were retrospectively analyzed.According to the different degree of dilution,the patients were divided into the 30% Hct group(group A) and 25% Hct group(group B).The blood coagulation function and systemic inflammatory reaction between two groups before operation(T0),after operation(T1) and at the end of operation(T2) were compared.Results:The hemoglobin level and platelet count in two groups at T2 significantly decreased compared with at T0(P<0.01),and the prothrombin time in two groups at T1 was significantly higher than that at T0 and T2(P<0.05 to P<0.01).The hemoglobin level in group B at T2 was significantly lower than that in group A(P<0.01),and the platelet count in group B at T1 and T2 were significantly lower than that in group A(P<0.01).The differences of prothrombin time and activated partial thromboplastin time between two groups at all time-points were not statistically significant(P>0.05).The levels of interleukin(IL)IL-1β,IL-6,atrial natriuretic polypeptide(ANP) in two groups at T1 and T2 were significantly higher than those at T0(P<0.05 to P<0.01),and the pulmonary compliance(CL) at T1 and T2 were significantly lower than that at T0(P<0.01).The levels of IL-1β and CL in group B at T1 and T2 were significantly lower than those in group A(P<0.01),and the level of ANP in group B at T2 was higher than that in group A(P<0.05).Conclusions:The effects of different degrees of acute hypervolumic hemodilution on the blood coagulation function and systemic inflammatory response in elderly patients are different.The low degree of dilution may affect the oxygenation,reduce the blood coagulation function,and aggravate the systemic inflammatory response.
2018, 43(4): 475-477.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.014
Abstract:
Objective:To explore the clinical effects of Roux-en-Y Uncut anastomosis(Uncut type) and Roux-en-Y anastomosis(R-Y type) in laparoscopic radical distal gastrectomy.Methods:The clinical data of 86 patients treated with laparoscopic radical distal gastrectomy from March 2015 to March 2016 were retrospectively analyzed.The patients were divided into the observation group and control group according to the different ways of reconstruction of gastrointestinal jejunum.The observation group was anastomosed with Uncut type of gastric jejunum,and the control group was anastomosed with R-Y type of gastric jejunum.The total operation time,intraoperative total bleeding,postoperative anus ventilation time,postoperative feeding fluid time,postoperative Roux retention syndrome(RSS) and postoperative hospitalization time between two groups were compared.Results:The difference of the total operative time between two groups was not statistically significant(P>0.05).The differences of the intraoperative total bleeding,postoperative anus ventilation time,postoperative feeding fluid time,postoperative RSS and postoperative hospitalization time between two groups were statistically significant(P<0.05 to P<0.01).Conclusions:In laparoscopic radical resection of distal gastric carcinoma,the incidence of postoperative RSS complications and postoperative hospital stay in patients treated with gastric jejunal Uncut type anastomosis were less than those in patients treated with R-Y type anastomosis.The gastric jejunal Uncut type anastomosis has good effect,and is a safe and effective operation method,which can improve the postoperative quality of life of patients.
Objective:To explore the clinical effects of Roux-en-Y Uncut anastomosis(Uncut type) and Roux-en-Y anastomosis(R-Y type) in laparoscopic radical distal gastrectomy.Methods:The clinical data of 86 patients treated with laparoscopic radical distal gastrectomy from March 2015 to March 2016 were retrospectively analyzed.The patients were divided into the observation group and control group according to the different ways of reconstruction of gastrointestinal jejunum.The observation group was anastomosed with Uncut type of gastric jejunum,and the control group was anastomosed with R-Y type of gastric jejunum.The total operation time,intraoperative total bleeding,postoperative anus ventilation time,postoperative feeding fluid time,postoperative Roux retention syndrome(RSS) and postoperative hospitalization time between two groups were compared.Results:The difference of the total operative time between two groups was not statistically significant(P>0.05).The differences of the intraoperative total bleeding,postoperative anus ventilation time,postoperative feeding fluid time,postoperative RSS and postoperative hospitalization time between two groups were statistically significant(P<0.05 to P<0.01).Conclusions:In laparoscopic radical resection of distal gastric carcinoma,the incidence of postoperative RSS complications and postoperative hospital stay in patients treated with gastric jejunal Uncut type anastomosis were less than those in patients treated with R-Y type anastomosis.The gastric jejunal Uncut type anastomosis has good effect,and is a safe and effective operation method,which can improve the postoperative quality of life of patients.
2018, 43(4): 478-480,484.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.015
Abstract:
Objective:To compare the clinical efficacy between three nasal endoscopic approaches in the treatment of antrochoanal polyp(ACP).Methods:Fifty-one patients with ACP were randomly divided into the group A(21 cases),group B(15 cases) and group C(15 cases).The group A,group B and group C were operated from maxillary sinus ostium through middle meatus,inferior meatus and canine fossa,respectively.Results:The differences of the operation time and intraoperative bleeding between three groups were statistically significant(P<0.01),and the operation time and intraoperative bleeding in group A and group B were significantly more than those in group C(P<0.01).During the following up for 12 to 48 months,there were no statistical significance in the total and partial control rate between three groups(P>0.05),and the uncontrol rate in group A was significantly higher than that in group B and group C(P<0.01 and P<0.05).Two cases with nasal adhesion in group A,and no complication in group B and group C were found,and there was no statistical significance in the incidence rate of postoperative complication between three groups(P>0.05).Four cases in group A recurred,1 case in group B recurred,no case in group C recurred,and the difference of the recurrence rate between three groups was not statistically significant(P>0.05).Conclusions:Nasal endoscopy in the treatment of ACP is safe,which can effectively control the recurrence rate.The surgical approaches through inferior meatus and canine fossa can effectively control the patients' condition.The surgery through canine fossa hasthe advantages of short time,little bleeding and good view.
Objective:To compare the clinical efficacy between three nasal endoscopic approaches in the treatment of antrochoanal polyp(ACP).Methods:Fifty-one patients with ACP were randomly divided into the group A(21 cases),group B(15 cases) and group C(15 cases).The group A,group B and group C were operated from maxillary sinus ostium through middle meatus,inferior meatus and canine fossa,respectively.Results:The differences of the operation time and intraoperative bleeding between three groups were statistically significant(P<0.01),and the operation time and intraoperative bleeding in group A and group B were significantly more than those in group C(P<0.01).During the following up for 12 to 48 months,there were no statistical significance in the total and partial control rate between three groups(P>0.05),and the uncontrol rate in group A was significantly higher than that in group B and group C(P<0.01 and P<0.05).Two cases with nasal adhesion in group A,and no complication in group B and group C were found,and there was no statistical significance in the incidence rate of postoperative complication between three groups(P>0.05).Four cases in group A recurred,1 case in group B recurred,no case in group C recurred,and the difference of the recurrence rate between three groups was not statistically significant(P>0.05).Conclusions:Nasal endoscopy in the treatment of ACP is safe,which can effectively control the recurrence rate.The surgical approaches through inferior meatus and canine fossa can effectively control the patients' condition.The surgery through canine fossa hasthe advantages of short time,little bleeding and good view.
2018, 43(4): 481-484.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.016
Abstract:
Objective:To compare the clinical efficacy between percutaneous pedicle fixation and open reduction internal fixation in the treatment of thoracolumbar fractures.Methods:Fifty thoracolumbar fractures patients treated with percutaneous pedicle fixation and 40 thoracolumbar fractures patients treated with open reduction internal fixation were divided into the micro-invasive group and posterior group,respectively.The operation situation,change of imaging index and postoperative pain between two groups were compared.Results:The average intraoperative blood loss and hospital stay in micro-invasive group[(36.17±6.72)mL and (10.28±1.37)d] were less than those in posterior group[(387.13 ±104.39)mL and (13.86±2.51)d],respectively(P<0.01).The VAS scores in micro-invasive group after 2 weeks,3 weeks and 6 months of operation were lower than those in posterior group(P<0.01).The differences of the vertebral frontal height and convex Cobb's angle between two groups before operaton,after operation,postoperative 3 months and postoperative 1 year were not statistically significant(P>0.05).Conclusions:The percutaneous pedicle fixation in treating the thoracolumbar fractures can effectively stabilize the injured vertebrae,shorten hospitalization time,effectively relieve the suffering of the patients with postoperative functional exercise.
Objective:To compare the clinical efficacy between percutaneous pedicle fixation and open reduction internal fixation in the treatment of thoracolumbar fractures.Methods:Fifty thoracolumbar fractures patients treated with percutaneous pedicle fixation and 40 thoracolumbar fractures patients treated with open reduction internal fixation were divided into the micro-invasive group and posterior group,respectively.The operation situation,change of imaging index and postoperative pain between two groups were compared.Results:The average intraoperative blood loss and hospital stay in micro-invasive group[(36.17±6.72)mL and (10.28±1.37)d] were less than those in posterior group[(387.13 ±104.39)mL and (13.86±2.51)d],respectively(P<0.01).The VAS scores in micro-invasive group after 2 weeks,3 weeks and 6 months of operation were lower than those in posterior group(P<0.01).The differences of the vertebral frontal height and convex Cobb's angle between two groups before operaton,after operation,postoperative 3 months and postoperative 1 year were not statistically significant(P>0.05).Conclusions:The percutaneous pedicle fixation in treating the thoracolumbar fractures can effectively stabilize the injured vertebrae,shorten hospitalization time,effectively relieve the suffering of the patients with postoperative functional exercise.
2018, 43(4): 485-487.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.017
Abstract:
Objective:To investigate the common risk factors of cerebral infarction in young people.Methods:The clinical data of 197 patients with the first attacked cerebral infarction in different age groups were retrospectively analyzed.The relationship between young people and common risk factors of cerebral infarction was analyzed.Results:The ratio of male patients in youth group was higher than that in middle and old age groups(P<0.01),and the difference of which between middle and old age groups was not statistically significant(P>0.05).The obesity rate in youth group was lower than that in middle and old age groups(P<0.01),and the difference of which between middle and old age groups was not statistically significant(P>0.05).The differences of smoking,drinking,history of hypertension among three groups were not statistically significant(P>0.05).The levels of blood glucose and homocysteine in old age group were the highest,and which gradually decreased in middle age group and youth group(P<0.01).The levels of triglyceride and total cholesterol in middle age group and old age group were higher than those in youth group(P<0.01),and the difference of which between middle and old age groups was not statistically significant(P>0.05).Conclusions:The cerebral infarction in young people is common in male patient,which is related to the blood pressure increasing,smoking,drinking alcohol,and so on.Standardized antihypertensive therapy,quit smoking and drinking can help to prevent the occurrence and development of cerebral infarction in young people.
Objective:To investigate the common risk factors of cerebral infarction in young people.Methods:The clinical data of 197 patients with the first attacked cerebral infarction in different age groups were retrospectively analyzed.The relationship between young people and common risk factors of cerebral infarction was analyzed.Results:The ratio of male patients in youth group was higher than that in middle and old age groups(P<0.01),and the difference of which between middle and old age groups was not statistically significant(P>0.05).The obesity rate in youth group was lower than that in middle and old age groups(P<0.01),and the difference of which between middle and old age groups was not statistically significant(P>0.05).The differences of smoking,drinking,history of hypertension among three groups were not statistically significant(P>0.05).The levels of blood glucose and homocysteine in old age group were the highest,and which gradually decreased in middle age group and youth group(P<0.01).The levels of triglyceride and total cholesterol in middle age group and old age group were higher than those in youth group(P<0.01),and the difference of which between middle and old age groups was not statistically significant(P>0.05).Conclusions:The cerebral infarction in young people is common in male patient,which is related to the blood pressure increasing,smoking,drinking alcohol,and so on.Standardized antihypertensive therapy,quit smoking and drinking can help to prevent the occurrence and development of cerebral infarction in young people.
2018, 43(4): 488-490,493.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.018
Abstract:
Objective:To analyze the serum level changes of procalcitonin(PCT) and C-reactive protein(CRP) in children with Mycoplasma pneumoniae pneumonia(MPP),and its clinical significance.Methods:Forty-seven children with pneumonia were divided into the MPP group(n=24) and bacterial pneumonia(BP) group(n=23) according to the disease,and 20 physical examination healthy children were set as the control group during the same period.The serum levels of PCT and CRP among three groups were compared.The MPP group was subdivided into the acute phase and recovery phase according to the course of disease,and the levels of PCT and CRP between two phases were compared.Results:The serum levels of CRP and PCT in MPP group and BP group were significantly higher than those in control group(P<0.01),and the serum levels of CRP and PCT in MPP group were significantly lower than those in BP group(P<0.01).Among the MMP group,the serum levels of CRP and PCT in children in recovery phase were significantly lower than those in children in acute phase(P<0.01).The serum level of CRP in MPP group was set as 18.95 mg/L in recovery phase,the sensitivity and specificity of CRP in diagnosing MPP were 82.6% and 66.7%,respectively,and the area under ROC curve(AUC) was 0.743.The serum level of PCT was set as 0.36 ng/mL,the sensitivity and specificity of PCT in diagnosing MPP were 69.6% and 83.3%%,respectively,and the AUC was 0.752.The sensitivity and specificity of CRP combined with PCT in diagnosing MPP were 87.0% and 87.5%,respectively,and the AUC was 0.881.Conclusions:The serum levels of PCT and CRP in children with MPP significantly increase,which can be used as an important index in evaluating the illness and early diagnosis of MPP.
Objective:To analyze the serum level changes of procalcitonin(PCT) and C-reactive protein(CRP) in children with Mycoplasma pneumoniae pneumonia(MPP),and its clinical significance.Methods:Forty-seven children with pneumonia were divided into the MPP group(n=24) and bacterial pneumonia(BP) group(n=23) according to the disease,and 20 physical examination healthy children were set as the control group during the same period.The serum levels of PCT and CRP among three groups were compared.The MPP group was subdivided into the acute phase and recovery phase according to the course of disease,and the levels of PCT and CRP between two phases were compared.Results:The serum levels of CRP and PCT in MPP group and BP group were significantly higher than those in control group(P<0.01),and the serum levels of CRP and PCT in MPP group were significantly lower than those in BP group(P<0.01).Among the MMP group,the serum levels of CRP and PCT in children in recovery phase were significantly lower than those in children in acute phase(P<0.01).The serum level of CRP in MPP group was set as 18.95 mg/L in recovery phase,the sensitivity and specificity of CRP in diagnosing MPP were 82.6% and 66.7%,respectively,and the area under ROC curve(AUC) was 0.743.The serum level of PCT was set as 0.36 ng/mL,the sensitivity and specificity of PCT in diagnosing MPP were 69.6% and 83.3%%,respectively,and the AUC was 0.752.The sensitivity and specificity of CRP combined with PCT in diagnosing MPP were 87.0% and 87.5%,respectively,and the AUC was 0.881.Conclusions:The serum levels of PCT and CRP in children with MPP significantly increase,which can be used as an important index in evaluating the illness and early diagnosis of MPP.
2018, 43(4): 491-493.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.019
Abstract:
Objective:To observe the effects of dexmedetomidine on the emergence agitation(EA) in patients treated with laparoscopic cholecystectomy.Methods:Sixty patients with ASAⅠ~Ⅱ laparoscopic cholecystectomy were randomly divided into the dexmedetomidine group and remifentanil group using double blind method(30 cases each group).Two groups were treated with tracheal intubation inhalation and intravenous injection combined with general anesthesia.The dexmedetomidine group was injected intravenously with 1.0 ug/kg of dexmedetomidine before ten minutes of induction,the 1ug/kg of remifentanil,2 mg/kg of propofol and 0.6 mg/kg of rocuronium were intravenously injected,0.2~0.5 μg·kg-1·h-1 of dexmedetomidine,3 mg·kg-1·h-1 of propofol,0.2 μg·kg-1·min-1 of remifentanil and 1%~2% of sevoflurane were continuously inhaled,and 0.15 mg/kg of rocuronium bromide was intermittently intravenously injected in turn in dexmedetomidine group.Except the dexmedetomidine in remifentanil group,the other drugs were used in consistent with the dexmedetomidine group.The recovery time and EA scores before extubation,at extubation and after 10 min of extubation between two groups were compared.Results:There was no statistical significance in the operation time,spontaneous breathing recovery time and eye opening time between two groups(P>0.05).The SBP in dexmedetomidine group at different time-points were lower than that in remifentanil group(P<0.05 to P<0.01).The difference of HR at T1 between two groups was not statistically significant(P>0.05),and the differences of HR in dexmedetomidine group at T2 and T3 were significantly lower than that in remifentanil group(P<0.01).The EA scores in dexmedetomidine group before extubation,at extubation and after 10 min of extubation were significantly lower than that in remifentanil group(P<0.01).Conclusions:Dexmedetomidine can maintain the stabilization of hemodynamics,and reduce the incidence of EA in patients treated with laparoscopic cholecystectomy.
Objective:To observe the effects of dexmedetomidine on the emergence agitation(EA) in patients treated with laparoscopic cholecystectomy.Methods:Sixty patients with ASAⅠ~Ⅱ laparoscopic cholecystectomy were randomly divided into the dexmedetomidine group and remifentanil group using double blind method(30 cases each group).Two groups were treated with tracheal intubation inhalation and intravenous injection combined with general anesthesia.The dexmedetomidine group was injected intravenously with 1.0 ug/kg of dexmedetomidine before ten minutes of induction,the 1ug/kg of remifentanil,2 mg/kg of propofol and 0.6 mg/kg of rocuronium were intravenously injected,0.2~0.5 μg·kg-1·h-1 of dexmedetomidine,3 mg·kg-1·h-1 of propofol,0.2 μg·kg-1·min-1 of remifentanil and 1%~2% of sevoflurane were continuously inhaled,and 0.15 mg/kg of rocuronium bromide was intermittently intravenously injected in turn in dexmedetomidine group.Except the dexmedetomidine in remifentanil group,the other drugs were used in consistent with the dexmedetomidine group.The recovery time and EA scores before extubation,at extubation and after 10 min of extubation between two groups were compared.Results:There was no statistical significance in the operation time,spontaneous breathing recovery time and eye opening time between two groups(P>0.05).The SBP in dexmedetomidine group at different time-points were lower than that in remifentanil group(P<0.05 to P<0.01).The difference of HR at T1 between two groups was not statistically significant(P>0.05),and the differences of HR in dexmedetomidine group at T2 and T3 were significantly lower than that in remifentanil group(P<0.01).The EA scores in dexmedetomidine group before extubation,at extubation and after 10 min of extubation were significantly lower than that in remifentanil group(P<0.01).Conclusions:Dexmedetomidine can maintain the stabilization of hemodynamics,and reduce the incidence of EA in patients treated with laparoscopic cholecystectomy.
2018, 43(4): 494-497.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.020
Abstract:
Objective:To investigate the effects of thoracic laparoscopy combined with esophagectomy and left cervical anastomosis,and its effect on nutritional status of patients.Methods:One hundred and eighteen esophageal cancer patients were divided into the control group and observation group according to the operation method(59 cases each group).The control group were treated with conventional thoracic esophageal cancer resection combined with gastroesophageal anastomosis,and the observation group were treated with thoracic laparoscopy surgery combined with esophageal cancer resection and left neck anastomosis.The treatment effect between two groups were compared.Results:The improvement of serum ALB and Hb in two groups after 1 and 2 months of operation were better than those before operation(P<0.01),and which in observation group was better than that in control group(P<0.01).After 3 months of operation,the quality of life in observation group was significantly higher than that in control group(P<0.01).The total incidence of complications in observation group(6.8%) was lower than that in control group(22.0%)(P<0.05).Conclusions:Thoracoscopy combined with esophagectomy and left cervical anastomosis in the treatment of esophageal cancer is effective,and few complication,which can improve the nutritional level and quality of life,and promote the recovery of patients.
Objective:To investigate the effects of thoracic laparoscopy combined with esophagectomy and left cervical anastomosis,and its effect on nutritional status of patients.Methods:One hundred and eighteen esophageal cancer patients were divided into the control group and observation group according to the operation method(59 cases each group).The control group were treated with conventional thoracic esophageal cancer resection combined with gastroesophageal anastomosis,and the observation group were treated with thoracic laparoscopy surgery combined with esophageal cancer resection and left neck anastomosis.The treatment effect between two groups were compared.Results:The improvement of serum ALB and Hb in two groups after 1 and 2 months of operation were better than those before operation(P<0.01),and which in observation group was better than that in control group(P<0.01).After 3 months of operation,the quality of life in observation group was significantly higher than that in control group(P<0.01).The total incidence of complications in observation group(6.8%) was lower than that in control group(22.0%)(P<0.05).Conclusions:Thoracoscopy combined with esophagectomy and left cervical anastomosis in the treatment of esophageal cancer is effective,and few complication,which can improve the nutritional level and quality of life,and promote the recovery of patients.
2018, 43(4): 497-500.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.021
Abstract:
Objective:To analyze the effects of whole-brain 3D conformal radiotherapy and analysis of factors influencing prognosis in brain metastases patients.Methods:Among 50 patients with malignant tumor brain metastases,28 cases were were irradiated with local dose,and 30 cases were treated with radiotherapy combined chemotherapy.According to the objective curative effect standard of WHO solid tumor and evaluation standard of radiotherapy efficacy of RTOG brain tumor,the curative effect of radiotherapy was evaluated.The survival rate was statistically analyzed using Kaplan-Meier,and the related factors influencing prognosis were analyzed.Results:The total remission rate(CR),partial remission rate(PR),stability rate and progression rate in 50 patients with brain metastases were 4%(2/50),38%(19/50),50%(25/50),and 8%(4/50),respectively.The total effective rate,disease control rate,and remission rate of clinical symptoms were 42%(21/50),92%(46/50) and 86%(43/50),respectively.The median survival time was 10.2 months,and the 6-month,1-and 2-year survival rates were 76%,38% and 8%,respectively.The univariate analysis showed that the radiotherapy combined with chemotherapy had better survival advantage over radiotherapy alone(P<0.01),the control rate of brain metastases increased,and the overall survival rate did not significant be affected(P>0.05).Cox multivariate analysis showed that the KPS score,control of the extracranial primary focus,and objective remission rate were the independent influencing factors in the survival rate of patients(P<0.05 to P<0.01).Conclusions:Three dimensional conformal radiotherapy in the treatment of brain metastases can significantly relieve the clinical symptoms,and prolong the survival of patients.
Objective:To analyze the effects of whole-brain 3D conformal radiotherapy and analysis of factors influencing prognosis in brain metastases patients.Methods:Among 50 patients with malignant tumor brain metastases,28 cases were were irradiated with local dose,and 30 cases were treated with radiotherapy combined chemotherapy.According to the objective curative effect standard of WHO solid tumor and evaluation standard of radiotherapy efficacy of RTOG brain tumor,the curative effect of radiotherapy was evaluated.The survival rate was statistically analyzed using Kaplan-Meier,and the related factors influencing prognosis were analyzed.Results:The total remission rate(CR),partial remission rate(PR),stability rate and progression rate in 50 patients with brain metastases were 4%(2/50),38%(19/50),50%(25/50),and 8%(4/50),respectively.The total effective rate,disease control rate,and remission rate of clinical symptoms were 42%(21/50),92%(46/50) and 86%(43/50),respectively.The median survival time was 10.2 months,and the 6-month,1-and 2-year survival rates were 76%,38% and 8%,respectively.The univariate analysis showed that the radiotherapy combined with chemotherapy had better survival advantage over radiotherapy alone(P<0.01),the control rate of brain metastases increased,and the overall survival rate did not significant be affected(P>0.05).Cox multivariate analysis showed that the KPS score,control of the extracranial primary focus,and objective remission rate were the independent influencing factors in the survival rate of patients(P<0.05 to P<0.01).Conclusions:Three dimensional conformal radiotherapy in the treatment of brain metastases can significantly relieve the clinical symptoms,and prolong the survival of patients.
2018, 43(4): 501-502,506.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.022
Abstract:
Objective:To investigate the effects of liraglutide on the plasma testosterone level in type 2 diabetes mellitus(T2DM) male patients complicated with obesity/overweight.Methods:A total of 40 obese or overweight T2DM patients were randomly divided into the control group and observation group(20 cases each group).The control group and observation group were treated with routine method and liraglutide combined with routine method,respectively.After 6 months of treatment,the clinical effiency of liraglutide,and effect of liraglutide on the plasma testosterone level were observed.Results:Before treatment,the differences of the levels of FPG,HbA1c,HOMA-IR and HOMA-β between two groups were not statistically significant(P>0.05).After treatment,the levels of FPG and HbA1c in control group,and all indexes in observation group were significantly improved compared with before treatment(P<0.01).Compared with the control group,the levels of FPG and HbA1c,and level of HOMA-β in observation group significantly decreased and increased after treatment,respectively(P<0.05 to P<0.01).The plasma level of testosterone in observation group after treatment was significantly higher than that before treatment(P<0.01),and the difference of which in control group between before and after treatment was not statistically significant(P>0.05).The differences of the plasma levels of testosterone between two groups were not statistically significant before and after treatment(P>0.05).Conclusions:Liraglutide can effectively reduce the blood glucose,improve the function of pancreas islet β-cells,and enhance the plasma level of testosterone in T2DM patients complicated with obesity or overweight.
Objective:To investigate the effects of liraglutide on the plasma testosterone level in type 2 diabetes mellitus(T2DM) male patients complicated with obesity/overweight.Methods:A total of 40 obese or overweight T2DM patients were randomly divided into the control group and observation group(20 cases each group).The control group and observation group were treated with routine method and liraglutide combined with routine method,respectively.After 6 months of treatment,the clinical effiency of liraglutide,and effect of liraglutide on the plasma testosterone level were observed.Results:Before treatment,the differences of the levels of FPG,HbA1c,HOMA-IR and HOMA-β between two groups were not statistically significant(P>0.05).After treatment,the levels of FPG and HbA1c in control group,and all indexes in observation group were significantly improved compared with before treatment(P<0.01).Compared with the control group,the levels of FPG and HbA1c,and level of HOMA-β in observation group significantly decreased and increased after treatment,respectively(P<0.05 to P<0.01).The plasma level of testosterone in observation group after treatment was significantly higher than that before treatment(P<0.01),and the difference of which in control group between before and after treatment was not statistically significant(P>0.05).The differences of the plasma levels of testosterone between two groups were not statistically significant before and after treatment(P>0.05).Conclusions:Liraglutide can effectively reduce the blood glucose,improve the function of pancreas islet β-cells,and enhance the plasma level of testosterone in T2DM patients complicated with obesity or overweight.
2018, 43(4): 503-506.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.023
Abstract:
Objective:To compare the effects and safety between sitagliptin and pioglitazone in the treatment of the obesity type 2 diabetes mellitus patients unresponsive to treatment with metformin.Methods:Ninety-eight obesity type 2 diabetes mellitus patients unresponsive to treatment with metformin were divided into the group A and group B according to random number table method(49 cases each group).The group A and group B were additionally treated with sitagliptin and pioglitazone,respectively.The levels of blood glucose,insulin,body mass index(BMI),blood lipid and insulin resistance index,and adverse reactions between two groups were compared.Results:Before treatment,the differences of the levels of blood glucose,insulin,BMI,blood lipid and insulin resistance between two groups were not statistically significant(P>0.05),and all indexes in two groups were significantly improved after treatment.After treatment,the differences of the levels of fasting blood glucose,insulin and blood lipid between two groups were not statistically significant(P>0.05),and the levels of postprandial 2 h blood glucose and BMI in group A were significantly lower than those in group B(P<0.05).The incidence rates of adverse reactions in group A and group B were 10.20% and 14.29%,respectively,the difference of which was not statistically significant(P>0.05),and there were not severe adverse reactions in two groups.Conclusions:The effects of obesity type 2 diabetes mellitus treated with metformin combined with sitagliptin or pioglitazone are ideal and safe,but the effects of sitagliptin on postprandial blood glucose and body weight control are better than those of pioglitazone.
Objective:To compare the effects and safety between sitagliptin and pioglitazone in the treatment of the obesity type 2 diabetes mellitus patients unresponsive to treatment with metformin.Methods:Ninety-eight obesity type 2 diabetes mellitus patients unresponsive to treatment with metformin were divided into the group A and group B according to random number table method(49 cases each group).The group A and group B were additionally treated with sitagliptin and pioglitazone,respectively.The levels of blood glucose,insulin,body mass index(BMI),blood lipid and insulin resistance index,and adverse reactions between two groups were compared.Results:Before treatment,the differences of the levels of blood glucose,insulin,BMI,blood lipid and insulin resistance between two groups were not statistically significant(P>0.05),and all indexes in two groups were significantly improved after treatment.After treatment,the differences of the levels of fasting blood glucose,insulin and blood lipid between two groups were not statistically significant(P>0.05),and the levels of postprandial 2 h blood glucose and BMI in group A were significantly lower than those in group B(P<0.05).The incidence rates of adverse reactions in group A and group B were 10.20% and 14.29%,respectively,the difference of which was not statistically significant(P>0.05),and there were not severe adverse reactions in two groups.Conclusions:The effects of obesity type 2 diabetes mellitus treated with metformin combined with sitagliptin or pioglitazone are ideal and safe,but the effects of sitagliptin on postprandial blood glucose and body weight control are better than those of pioglitazone.
2018, 43(4): 507-509.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.024
Abstract:
Objective:To investigate the application of nifedipine combined with phentolamine and magnesium sulfate in patients with hypertension,and their quality of life.Methods:One hundred and two hypertension patients were divided into the control group and observation group(51 cases each group).The control group was treated with nifedipine,and the observation group was treated with nifedipine combined with phentolamine and magnesium sulfate.The blood pressure level,medication compliance,disease awareness rate,complication and quality of life between two groups were compared.Results:The differences of the systolic pressure and diastolic pressure between two groups before intervention were not statistically significant(P>0.05),the systolic pressure and diastolic pressure in two groups after intervention significantly decreased compared with before intervention(P<0.01),and the systolic pressure and diastolic pressure in observation group after intervention were significantly lower than those in control group(P<0.01).After treatment,the ratio of hypertension patients in observation group was significantly lower than that in control group(P<0.01),the medication compliance and disease awareness rate in observation group were better than those in control group(P<0.05 and P<0.01),and the incidence rate of complications in observation group was significantly lower than that in control group(P<0.01).The differences of the scores of health sensation,physical function,sleep state,life satisfaction and cognitive function between two groups before treatment were not statistically significant(P>0.05),the indictor scores in two groups after treatment were significantly higher than those of before treatment(P<0.01),and which in observation group was significantly higher than that in control group(P<0.01).Conclusions:The nifedipine combined with phentolamine and magnesium sulfate in the treatment of hypertensive patients can effectively reduce the blood pressure,and improve their quality of life,which is worthy of use in clinic.
Objective:To investigate the application of nifedipine combined with phentolamine and magnesium sulfate in patients with hypertension,and their quality of life.Methods:One hundred and two hypertension patients were divided into the control group and observation group(51 cases each group).The control group was treated with nifedipine,and the observation group was treated with nifedipine combined with phentolamine and magnesium sulfate.The blood pressure level,medication compliance,disease awareness rate,complication and quality of life between two groups were compared.Results:The differences of the systolic pressure and diastolic pressure between two groups before intervention were not statistically significant(P>0.05),the systolic pressure and diastolic pressure in two groups after intervention significantly decreased compared with before intervention(P<0.01),and the systolic pressure and diastolic pressure in observation group after intervention were significantly lower than those in control group(P<0.01).After treatment,the ratio of hypertension patients in observation group was significantly lower than that in control group(P<0.01),the medication compliance and disease awareness rate in observation group were better than those in control group(P<0.05 and P<0.01),and the incidence rate of complications in observation group was significantly lower than that in control group(P<0.01).The differences of the scores of health sensation,physical function,sleep state,life satisfaction and cognitive function between two groups before treatment were not statistically significant(P>0.05),the indictor scores in two groups after treatment were significantly higher than those of before treatment(P<0.01),and which in observation group was significantly higher than that in control group(P<0.01).Conclusions:The nifedipine combined with phentolamine and magnesium sulfate in the treatment of hypertensive patients can effectively reduce the blood pressure,and improve their quality of life,which is worthy of use in clinic.
2018, 43(4): 510-512.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.025
Abstract:
Objective:To investigate the effect of different doses of thyroid stimulating hormone(TSH) on the postoperative related indicators in patients with differentiated thyroid cancer.Methods:Fifty differentiated thyroid cancer patients scheduled by operation were investigated.After 30 days of operation,the patients were treated with removing remnant thyroid residual tissue using 131I combined with TSH therapy.Patients were divided into the conventional dose group and inhibitive dose group according to the different dose of TSH(25 cases each group).The conventional dose group was treated with 2.0 μg/kg L-thyroxine sodium tablet,and the inhibitive dose group was treated with 2.5 μg/kg L-thyroxine sodium tablet.The levels of free triiodothyronine(FT3),serum free thyroxine(FT4),TSH,the serum levels of calcium,phosphorus and alkaline phosphatase (ALP),and the bone mineral density in L2-4 vertebral body,ward triangle,femoral large rotor and femoral shaft between before and after treatment in two groups were compared.Results:The differences of the levels of FT3,FT4 and TSH between two groups were not statistically significant before treatment(P>0.05).Compared with before treatment,the levels of FT3 and FT4 in two groups significantly increased(P<0.01),the TSH levels in two groups significantly decreased(P<0.01),the levels of FT3 and FT4 in inhibitive dose group were significantly higher than those in conventional dose group(P<0.01),and the levels of TSH in inhibitive dose group were significantly lower than that in conventional dose group after 12 months of treatment(P<0.01).The differences of the levels of calcium,phosphorus and ALP and bone mineral density in L2-4 vertebral body,ward triangle,femoral large rotor and femoral shaft in two groups between before and after treatment were not statistically significant(P>0.05).Conclusions:The conventional dose of L-thyroxine can ensure the normal physiological needs of patients with differentiated thyroid cancer,and the inhibitive dose can keep thyroid function in subclinical hyperthyroidism.The effect of different doses of L-thyroxine on bone metabolism and bone mineral density is small.The dose is selected on the basis of the actual situation of patients.
Objective:To investigate the effect of different doses of thyroid stimulating hormone(TSH) on the postoperative related indicators in patients with differentiated thyroid cancer.Methods:Fifty differentiated thyroid cancer patients scheduled by operation were investigated.After 30 days of operation,the patients were treated with removing remnant thyroid residual tissue using 131I combined with TSH therapy.Patients were divided into the conventional dose group and inhibitive dose group according to the different dose of TSH(25 cases each group).The conventional dose group was treated with 2.0 μg/kg L-thyroxine sodium tablet,and the inhibitive dose group was treated with 2.5 μg/kg L-thyroxine sodium tablet.The levels of free triiodothyronine(FT3),serum free thyroxine(FT4),TSH,the serum levels of calcium,phosphorus and alkaline phosphatase (ALP),and the bone mineral density in L2-4 vertebral body,ward triangle,femoral large rotor and femoral shaft between before and after treatment in two groups were compared.Results:The differences of the levels of FT3,FT4 and TSH between two groups were not statistically significant before treatment(P>0.05).Compared with before treatment,the levels of FT3 and FT4 in two groups significantly increased(P<0.01),the TSH levels in two groups significantly decreased(P<0.01),the levels of FT3 and FT4 in inhibitive dose group were significantly higher than those in conventional dose group(P<0.01),and the levels of TSH in inhibitive dose group were significantly lower than that in conventional dose group after 12 months of treatment(P<0.01).The differences of the levels of calcium,phosphorus and ALP and bone mineral density in L2-4 vertebral body,ward triangle,femoral large rotor and femoral shaft in two groups between before and after treatment were not statistically significant(P>0.05).Conclusions:The conventional dose of L-thyroxine can ensure the normal physiological needs of patients with differentiated thyroid cancer,and the inhibitive dose can keep thyroid function in subclinical hyperthyroidism.The effect of different doses of L-thyroxine on bone metabolism and bone mineral density is small.The dose is selected on the basis of the actual situation of patients.
2018, 43(4): 513-514.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.026
Abstract:
Objective:To compare the short-term efficacy and complications between video-assisted thoracoscopic surgery and conventional thoracotomy in treating non-small cell lung cancer(NSCLC).Methods:Sixty patients with NSCLC were randomly divided into the observation group(n=30) and control group(n=30).The control group was treated with conventional thoracotomy,while the observation group was treated with video-assisted thoracoscopic surgery.The short-term efficacy and complications between two groups were compared.Results:The difference of operation time,intraoperative bleeding,number of resected lymph nodes and dioxin dosage in two groups was not statistically significant(P>0.05).The day of postoperative pleural drainage over 50 mL,hospitalization time,and number of cases with arrhythmia,pneumonia,pulmonary embolism,wound infection in observation group were less than those in control group(P<0.01).Conclusions:The clinical efficacy of video-assisted thoracoscopic surgery in treating NSCLC is better than that of conventional open thoracic surgery,which has little complication and better value in clinic.
Objective:To compare the short-term efficacy and complications between video-assisted thoracoscopic surgery and conventional thoracotomy in treating non-small cell lung cancer(NSCLC).Methods:Sixty patients with NSCLC were randomly divided into the observation group(n=30) and control group(n=30).The control group was treated with conventional thoracotomy,while the observation group was treated with video-assisted thoracoscopic surgery.The short-term efficacy and complications between two groups were compared.Results:The difference of operation time,intraoperative bleeding,number of resected lymph nodes and dioxin dosage in two groups was not statistically significant(P>0.05).The day of postoperative pleural drainage over 50 mL,hospitalization time,and number of cases with arrhythmia,pneumonia,pulmonary embolism,wound infection in observation group were less than those in control group(P<0.01).Conclusions:The clinical efficacy of video-assisted thoracoscopic surgery in treating NSCLC is better than that of conventional open thoracic surgery,which has little complication and better value in clinic.
2018, 43(4): 515-518.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.027
Abstract:
Objective:To explore the clinical effects of self-locking zero incisure cervical vertebra fusion in the treatment of cervical spondylosis.Methods:The clinical data of cervical spondylosis patients treated with operation were retrospectively analyzed.The patients treated with self-locking zero incisure cervical vertebra fusion and corpectomy combined with interbody fusion cervical plate fixation were divided into the observation group and control group,respectively(15 cases each group).The clinical effects between two groups were compared.Results:The operation time,intraoperative blood loss and postoperative drainage amount in observation group were significantly lower than those in control group (P<0.01).The differences of VAS scores between two groups before operation and after 3 days of operation were not statistically significant(P>0.05).After 3 and 6 months of operation,the VAS scores in observation group were significantly lower than those in control group(P<0.05 and P<0.01).The difference of the JOA score between two groups before operation was not statistically significant(P>0.05).After 3 days,3 months and 6 months of operation,the JOA scores in observation group were higher than those in control group(P<0.05 to P<0.01).The differences of the cervical curvature and intervertebral height between two groups before and after operation were not statistically significant(P>0.05).Compared with before operation,the cervical curvature and intervertebral height in two groups were significantly improved after operation(P<0.01).After 3 months of operation,the scores of physical function,body role function,body pain,general health,vitality,social function,emotional role function and mental health in observation group were higher that than those in control group(P<0.05 to P<0.01).Conclusions:The self-locking zero incisure cervical vertebra fusion in the treatment of cervical spondylosis has little trauma,the postoperative nerve function and recovery of patients are good,the postoperative cervical curvature,intervertebral height and life quality of patients are significantly improved,which is worthy of clinical application.
Objective:To explore the clinical effects of self-locking zero incisure cervical vertebra fusion in the treatment of cervical spondylosis.Methods:The clinical data of cervical spondylosis patients treated with operation were retrospectively analyzed.The patients treated with self-locking zero incisure cervical vertebra fusion and corpectomy combined with interbody fusion cervical plate fixation were divided into the observation group and control group,respectively(15 cases each group).The clinical effects between two groups were compared.Results:The operation time,intraoperative blood loss and postoperative drainage amount in observation group were significantly lower than those in control group (P<0.01).The differences of VAS scores between two groups before operation and after 3 days of operation were not statistically significant(P>0.05).After 3 and 6 months of operation,the VAS scores in observation group were significantly lower than those in control group(P<0.05 and P<0.01).The difference of the JOA score between two groups before operation was not statistically significant(P>0.05).After 3 days,3 months and 6 months of operation,the JOA scores in observation group were higher than those in control group(P<0.05 to P<0.01).The differences of the cervical curvature and intervertebral height between two groups before and after operation were not statistically significant(P>0.05).Compared with before operation,the cervical curvature and intervertebral height in two groups were significantly improved after operation(P<0.01).After 3 months of operation,the scores of physical function,body role function,body pain,general health,vitality,social function,emotional role function and mental health in observation group were higher that than those in control group(P<0.05 to P<0.01).Conclusions:The self-locking zero incisure cervical vertebra fusion in the treatment of cervical spondylosis has little trauma,the postoperative nerve function and recovery of patients are good,the postoperative cervical curvature,intervertebral height and life quality of patients are significantly improved,which is worthy of clinical application.
2018, 43(4): 519-522.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.028
Abstract:
Objective:To investigate the effects of Banxia Xiexin decoction on the related genes of gastric cancer in patients with chronic atrophic gastritis.Methods:Ninety-six chronic atrophic gastritis patients with precancerous lesions were randomly divided into the control group group and observation group.The control group group and observation group were treated with Weifuchun tablets and Banxia Xiexin decoction,respectively.The clinical symptom score,overall therapeutic effect,distribution and expression of related gene of gastric cancer between two groups were compared.Results:After treatment,the clinical symptom score in observation group(8.96±4.37) was significantly lower than that in control group(13.68±4.96)(P<0.01),the Cyclin D1 score in observation group(1.30±0.48)was significantly lower than that in control group(1.83±0.51)(P<0.01),the PTEN score in observation group(2.96±0.50) was significantly higher than that in control group(2.33±0.42)(P<0.01),and the total effect rate in observation group(78%) was significantly higher than that in control group(54.35%)(P<0.05).Conclusions:The effect of Banxia Xiexin decoction on the related genes of gastric cancer in precancerous lesions patients with chronic atrophic gastritis is significant,which has an important significance.
Objective:To investigate the effects of Banxia Xiexin decoction on the related genes of gastric cancer in patients with chronic atrophic gastritis.Methods:Ninety-six chronic atrophic gastritis patients with precancerous lesions were randomly divided into the control group group and observation group.The control group group and observation group were treated with Weifuchun tablets and Banxia Xiexin decoction,respectively.The clinical symptom score,overall therapeutic effect,distribution and expression of related gene of gastric cancer between two groups were compared.Results:After treatment,the clinical symptom score in observation group(8.96±4.37) was significantly lower than that in control group(13.68±4.96)(P<0.01),the Cyclin D1 score in observation group(1.30±0.48)was significantly lower than that in control group(1.83±0.51)(P<0.01),the PTEN score in observation group(2.96±0.50) was significantly higher than that in control group(2.33±0.42)(P<0.01),and the total effect rate in observation group(78%) was significantly higher than that in control group(54.35%)(P<0.05).Conclusions:The effect of Banxia Xiexin decoction on the related genes of gastric cancer in precancerous lesions patients with chronic atrophic gastritis is significant,which has an important significance.
2018, 43(4): 522-524.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.029
Abstract:
Objective:To assess the efficacy and safety of hook wire-localized surgical biopsy guided by mammography for non-palpable breast lesions.Methods:The clinical data of 78 female patients with micro-lesions diagnosed by mammography,negative mammary diagnosed by palpation,were retrospectively analyzed.Thirty-five cases were treated with surgical biopsy located by general position method(group A),and 43 cases were treated with surgical biopsy located by hook wire guided by mammography(group B).Results:The disposable complete resection rate in group B(93.02%) was higher than that in group A(74.29%)(P<0.05).The satisfaction rate and mean time of puncturing localization in group B was 90.70% and 14.8 minutes,respectively.No guidance wire break,pneumothorax and massive hemorrhage in group B were found.The vagal response occurred in 4 cases,the symptom relieved after rest,and the operation of patients were successfully completed.Conclusions:The hook wire-localized surgical biopsy guided by mammography has a high accuracy,which is safe and effective in diagnosing non-palpable breast lesions.
Objective:To assess the efficacy and safety of hook wire-localized surgical biopsy guided by mammography for non-palpable breast lesions.Methods:The clinical data of 78 female patients with micro-lesions diagnosed by mammography,negative mammary diagnosed by palpation,were retrospectively analyzed.Thirty-five cases were treated with surgical biopsy located by general position method(group A),and 43 cases were treated with surgical biopsy located by hook wire guided by mammography(group B).Results:The disposable complete resection rate in group B(93.02%) was higher than that in group A(74.29%)(P<0.05).The satisfaction rate and mean time of puncturing localization in group B was 90.70% and 14.8 minutes,respectively.No guidance wire break,pneumothorax and massive hemorrhage in group B were found.The vagal response occurred in 4 cases,the symptom relieved after rest,and the operation of patients were successfully completed.Conclusions:The hook wire-localized surgical biopsy guided by mammography has a high accuracy,which is safe and effective in diagnosing non-palpable breast lesions.
2018, 43(4): 525-527,530.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.030
Abstract:
Objective:To explore the value of 128 slice spiral CT thin layer post-processing technique in the diagnosis of renal carcinoma and surgical method assessment.Methods:The clinical data of 20 renal cell carcinoma patients diagnosed by pathology were retrospectively analyzed.The invasion and metastasis of carcinoma in surrounding tissue based on the tumor location were observed using 128 slice spiral CT and post-processing technique.The operation method in 20 cases with renal carcinoma was assessed according to the tumor invasion,which was compared with the result of operation.Results:The coincidence rates of the results of 128 slice spiral CT thin layer post-processing technique with R.E.N.A.L scoring system and TNM staging of renal cell carcinoma were 100.0% and 90.0%,respectively.The accuracy of the evaluation of operation method before operation was 100%.Conclusions:The 128 slice spiral CT thin layer post-processing technique can accurately diagnose the renal carcinoma,which provide important reference value for the evaluation of clinical operation mode.
Objective:To explore the value of 128 slice spiral CT thin layer post-processing technique in the diagnosis of renal carcinoma and surgical method assessment.Methods:The clinical data of 20 renal cell carcinoma patients diagnosed by pathology were retrospectively analyzed.The invasion and metastasis of carcinoma in surrounding tissue based on the tumor location were observed using 128 slice spiral CT and post-processing technique.The operation method in 20 cases with renal carcinoma was assessed according to the tumor invasion,which was compared with the result of operation.Results:The coincidence rates of the results of 128 slice spiral CT thin layer post-processing technique with R.E.N.A.L scoring system and TNM staging of renal cell carcinoma were 100.0% and 90.0%,respectively.The accuracy of the evaluation of operation method before operation was 100%.Conclusions:The 128 slice spiral CT thin layer post-processing technique can accurately diagnose the renal carcinoma,which provide important reference value for the evaluation of clinical operation mode.
2018, 43(4): 528-530.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.031
Abstract:
Objective:To investigate the effects of acupoint acupuncture combined with bladder rehabilitation training on the prognosis of patients with spinal cord injury complicated with neurogenic bladder.Methods:One hundred and twenty-eight patients with spinal cord injury complicated with neurogenic bladder were randomly divided into the observation group(n=64) and control group(n=64).The control group was treated with clear intermittent catheterization combined with bladder function training guidance,and the observation group was additionally treated with acupoint acupuncture based on the control group.The intervention time was 8 weeks,and the bladder function recovery and quality of life between two groups were compared.Results:After intervention,the volume of bladder,frequency of voiding,residual urine volume and interval of catheterization in two groups were significantly better than those of before intervention(P<0.01),and which in observation group were significantly better than those in control group(P<0.01).Compared with before intervention,the latitude scores of physical,social,psychological and material function in two groups were significantly improved after intervention(P<0.01),and which in observation group were significantly higher than those in control group after intervention(P<0.01).Conclusions:Acupoint acupuncture combined with bladder rehabilitation training can effectively improve the bladder function and quality of life in patients with spinal cord injury complicated with neurogenic bladder.
Objective:To investigate the effects of acupoint acupuncture combined with bladder rehabilitation training on the prognosis of patients with spinal cord injury complicated with neurogenic bladder.Methods:One hundred and twenty-eight patients with spinal cord injury complicated with neurogenic bladder were randomly divided into the observation group(n=64) and control group(n=64).The control group was treated with clear intermittent catheterization combined with bladder function training guidance,and the observation group was additionally treated with acupoint acupuncture based on the control group.The intervention time was 8 weeks,and the bladder function recovery and quality of life between two groups were compared.Results:After intervention,the volume of bladder,frequency of voiding,residual urine volume and interval of catheterization in two groups were significantly better than those of before intervention(P<0.01),and which in observation group were significantly better than those in control group(P<0.01).Compared with before intervention,the latitude scores of physical,social,psychological and material function in two groups were significantly improved after intervention(P<0.01),and which in observation group were significantly higher than those in control group after intervention(P<0.01).Conclusions:Acupoint acupuncture combined with bladder rehabilitation training can effectively improve the bladder function and quality of life in patients with spinal cord injury complicated with neurogenic bladder.
2018, 43(4): 531-536.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.032
Abstract:
Objective:To investigate the application value of continuous care based on Omaha system in patients with permanent colostomy.Methods:The nursing problems of 44 patients with permanent colostomy were evaluated,and the patients were continuously nursed with Omaha system on the basis of conventional discharge guidance and following up.The cognition,behavior and status at discharge,after 7 days,2 weeks,1 month and 3 months of discharge were evaluated.Results:Among the patients after 7 days of discharge,the differences in the psychological society field(including social behavior indicators,role transform and state aspect) and health-related behavior field(including personal care and nutrition)were not statistically significant(P>0.05),and the differences of other fields were statistically significant compared with discharge(P<0.05 to P<0.01).Among the patients after 2 weeks of discharge,the difference in the psychological society field(including knowledge,behavior and condition) was not statistically significant compared after 7 days of discharge(P>0.05),the difference in the health related field(including sleep and rest behavior,condition and nutrition) was not statistically significant(P>0.05),and the differences of other fields were statistically significant compared with after 2 weeks of discharge(P<0.05 to P<0.01).Among the patients after 1 month of discharge,the differences in the health related field(including personal care and nutrition) and physiological field(including behavior and condition)were not statistically significant compared with after 2 weeks of discharge(P>0.05).Among the patients after 3 months of discharge,the differences in health related field(including sleep and rest behavior and nutrition)and physiological field(digestion-hydratation)were notstatistically significant(P>0.05),and the differences of other fields were statistically significant compared with after 1 month of discharge(P<0.05 to P<0.01).Conclusions:The Omaha system can evaluate the continuous nursing problem,provide the comprehensive intervention guideline,and improve the main nursing outcomein patients with permanent colostomy.
Objective:To investigate the application value of continuous care based on Omaha system in patients with permanent colostomy.Methods:The nursing problems of 44 patients with permanent colostomy were evaluated,and the patients were continuously nursed with Omaha system on the basis of conventional discharge guidance and following up.The cognition,behavior and status at discharge,after 7 days,2 weeks,1 month and 3 months of discharge were evaluated.Results:Among the patients after 7 days of discharge,the differences in the psychological society field(including social behavior indicators,role transform and state aspect) and health-related behavior field(including personal care and nutrition)were not statistically significant(P>0.05),and the differences of other fields were statistically significant compared with discharge(P<0.05 to P<0.01).Among the patients after 2 weeks of discharge,the difference in the psychological society field(including knowledge,behavior and condition) was not statistically significant compared after 7 days of discharge(P>0.05),the difference in the health related field(including sleep and rest behavior,condition and nutrition) was not statistically significant(P>0.05),and the differences of other fields were statistically significant compared with after 2 weeks of discharge(P<0.05 to P<0.01).Among the patients after 1 month of discharge,the differences in the health related field(including personal care and nutrition) and physiological field(including behavior and condition)were not statistically significant compared with after 2 weeks of discharge(P>0.05).Among the patients after 3 months of discharge,the differences in health related field(including sleep and rest behavior and nutrition)and physiological field(digestion-hydratation)were notstatistically significant(P>0.05),and the differences of other fields were statistically significant compared with after 1 month of discharge(P<0.05 to P<0.01).Conclusions:The Omaha system can evaluate the continuous nursing problem,provide the comprehensive intervention guideline,and improve the main nursing outcomein patients with permanent colostomy.
2018, 43(4): 540-542.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.034
Abstract:
Objective:To investigate the application effects of indwelling nasal-intestinal tube guided by bedside gastroscope in enteral nutrition of critical patients.Methods:Sixty critical patients were randomly divided into the observation group(30 cases indwelled with nasal-intestinal tube for nutrition support) and control group(30 cases indwelled with nasogastric tube for nutrition support).The nutrition indexes between two groups on the first and 10th day of intervention were compared.The success rate of catheterization,nausea vomiting,abdominal distension,diarrhea,anti-flow aspiration and tube plugging between two groups were compared.Results:The differences of the levels of serum albumin(ALB),prealbumin(PA) and hemoglobin(Hb) between two groups on the first day of intervention were not statistically significant(P >0.05).On the 10th day,the levels of indexes in observation group were higher than those in control group(P<0.05).The success rates of catheterization in two group were 100%,and the incidence rate of complications in observation group was significantly lower than that in control group(P<0.01).Conclusions:The indwelling nasal-intestinal tube guided by bedside gastroscope can significantly improve the nutritional status,and reduce the incidence of enteral nutrition complication of patients.
Objective:To investigate the application effects of indwelling nasal-intestinal tube guided by bedside gastroscope in enteral nutrition of critical patients.Methods:Sixty critical patients were randomly divided into the observation group(30 cases indwelled with nasal-intestinal tube for nutrition support) and control group(30 cases indwelled with nasogastric tube for nutrition support).The nutrition indexes between two groups on the first and 10th day of intervention were compared.The success rate of catheterization,nausea vomiting,abdominal distension,diarrhea,anti-flow aspiration and tube plugging between two groups were compared.Results:The differences of the levels of serum albumin(ALB),prealbumin(PA) and hemoglobin(Hb) between two groups on the first day of intervention were not statistically significant(P >0.05).On the 10th day,the levels of indexes in observation group were higher than those in control group(P<0.05).The success rates of catheterization in two group were 100%,and the incidence rate of complications in observation group was significantly lower than that in control group(P<0.01).Conclusions:The indwelling nasal-intestinal tube guided by bedside gastroscope can significantly improve the nutritional status,and reduce the incidence of enteral nutrition complication of patients.
2018, 43(4): 543-546.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.035
Abstract:
Objective:To explore the application value of multi-approach health education in postoperative patients with spinal fractures.Methods:Eighty-four patients with spinal fractures were randomly divided into the observation group and control group(42 cases each group).Two groups were treated with posterior transpedicular system reduction and fixation combined with spinal fusion.After surgery,the multi-approach health education and routine health education were implemented in observation group and control group,respectively.The total incidence rate of postoperative complications,time of initial functional exercise,length of hospital stay,compliance rate of self-care skills,and spinal cord independent function scores at discharge,after 1 month and 3 months of discharge between two groups were compared.Results:The total incidence rate of complications in observation group(9.52%) was lower than that in control group(26.19%) (P<0.05).The length of hospital stay and time of initial functional exercise in observation group were significantly shorter than those in control group(P<0.01).The compliance rate of self-care skills in observation group was higher than that in control group(P<0.05).At discharge,after 1 month and 3 months of discharge,the scores of the spinal cord independent function in observation group were higher than those in control group(P<0.05 to P<0.01).Conclusions:The application of multi-approach health education in patients with spinal fractures after surgery can reduce the complications,promote early functional exercise,improve the self-care abilities of patients after discharge,and promote the recovery of spinal function.
Objective:To explore the application value of multi-approach health education in postoperative patients with spinal fractures.Methods:Eighty-four patients with spinal fractures were randomly divided into the observation group and control group(42 cases each group).Two groups were treated with posterior transpedicular system reduction and fixation combined with spinal fusion.After surgery,the multi-approach health education and routine health education were implemented in observation group and control group,respectively.The total incidence rate of postoperative complications,time of initial functional exercise,length of hospital stay,compliance rate of self-care skills,and spinal cord independent function scores at discharge,after 1 month and 3 months of discharge between two groups were compared.Results:The total incidence rate of complications in observation group(9.52%) was lower than that in control group(26.19%) (P<0.05).The length of hospital stay and time of initial functional exercise in observation group were significantly shorter than those in control group(P<0.01).The compliance rate of self-care skills in observation group was higher than that in control group(P<0.05).At discharge,after 1 month and 3 months of discharge,the scores of the spinal cord independent function in observation group were higher than those in control group(P<0.05 to P<0.01).Conclusions:The application of multi-approach health education in patients with spinal fractures after surgery can reduce the complications,promote early functional exercise,improve the self-care abilities of patients after discharge,and promote the recovery of spinal function.
2018, 43(4): 557-559.
doi: 10.13898/j.cnki.issn.1000-2200.2018.04.040
Abstract:
Objective:To explore the effects of the flipped classroom teaching model on the critical thinking ability of clinical medical undergraduates.Methods:Sixty clinical medical undergraduates were randomly divided into the control group(n=30) and observation group(n=30).The control group was taught with the traditional teaching way,and the observation group was taught with the flipped classroom teaching model.At the end of the course,two groups were investigated using general critical thinking ability scale(Chinese version),and the teaching effects in two groups were evaluated.Results:The scores of comprehensive and systematic abilities in observation group were better than those in control group(P<0.01 and P<0.05).The differences of the scores of search,imagination,self-confidence,knowledge,cognition,and total score of the scale between two groups were not statistically significant(P>0.05).Conclusions:The flipped classroom teaching model can improve the critical thinking ability of clinical medical undergraduates.
Objective:To explore the effects of the flipped classroom teaching model on the critical thinking ability of clinical medical undergraduates.Methods:Sixty clinical medical undergraduates were randomly divided into the control group(n=30) and observation group(n=30).The control group was taught with the traditional teaching way,and the observation group was taught with the flipped classroom teaching model.At the end of the course,two groups were investigated using general critical thinking ability scale(Chinese version),and the teaching effects in two groups were evaluated.Results:The scores of comprehensive and systematic abilities in observation group were better than those in control group(P<0.01 and P<0.05).The differences of the scores of search,imagination,self-confidence,knowledge,cognition,and total score of the scale between two groups were not statistically significant(P>0.05).Conclusions:The flipped classroom teaching model can improve the critical thinking ability of clinical medical undergraduates.
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