Author Login
Experts Review
Academic Editor
Editor-in-chief
2018 Vol. 43, No. 6
Display Method:
2018, 43(6): 701-704.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.001
Abstract:
Objective:To develop a high performance liquid chromatography(HPLC) method for the determination of docetaxol concentration,and investigate the effects of different dosages of compound Kushen injection on the pharmacokinetics of multiple-dose docetaxol in rats.Methods:Twenty-four SD rats were randomly divided into the high-dose,medium-dose,low-dose and control groups(6 rats each group).The high-dose,medium-dose,low-dose and control groups were injected with 2 times clinical equivalent compound Kushen injection(3.6 mL/kg),clinical equivalent compound Kushen injection(1.8 mL/kg),1/2 clinical equivalent compound Kushen injection(0.9 mL/kg) and 0.9% normal saline solution by caudal vein for 7 days,respectively,and all rats were injected with 15 mg/kg of docetaxol after 5 min of administration on the seventh day.The blood samples in four groups at different time-points were analyzed,and the pharmacokinetic parameters were calculated.Results:After multiple-dose,the AUC and Cmax in high-dose and medium-dose groups were lower than those in control group(P<0.05),and the difference of which between low-dose group and control group was not statistically significant(P>0.05).Conclusions:The compound Kushen injection can reduce the blood concentration of docetaxol,there is a dose-dependent relationship between compound Kushen injection and docetaxel,which can provide a reference in clinical medication.
Objective:To develop a high performance liquid chromatography(HPLC) method for the determination of docetaxol concentration,and investigate the effects of different dosages of compound Kushen injection on the pharmacokinetics of multiple-dose docetaxol in rats.Methods:Twenty-four SD rats were randomly divided into the high-dose,medium-dose,low-dose and control groups(6 rats each group).The high-dose,medium-dose,low-dose and control groups were injected with 2 times clinical equivalent compound Kushen injection(3.6 mL/kg),clinical equivalent compound Kushen injection(1.8 mL/kg),1/2 clinical equivalent compound Kushen injection(0.9 mL/kg) and 0.9% normal saline solution by caudal vein for 7 days,respectively,and all rats were injected with 15 mg/kg of docetaxol after 5 min of administration on the seventh day.The blood samples in four groups at different time-points were analyzed,and the pharmacokinetic parameters were calculated.Results:After multiple-dose,the AUC and Cmax in high-dose and medium-dose groups were lower than those in control group(P<0.05),and the difference of which between low-dose group and control group was not statistically significant(P>0.05).Conclusions:The compound Kushen injection can reduce the blood concentration of docetaxol,there is a dose-dependent relationship between compound Kushen injection and docetaxel,which can provide a reference in clinical medication.
2018, 43(6): 705-707.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.002
Abstract:
Objective:To investigate the clinical effects of the ectopic bone of adipose-derived stem cells in the repair of large area defect of maxillary.Methods:The maxillary defect model of rabbit was established,and the defect was repaired with ectopic bone of autologous adipose-derived stem cells.The repair effect was observed using biopsy and imaging examination.Results:The biopsy results showed that the new bone tissue vascularization was good and mature bone tissue structure.After 2 months of reconstruction,the rectus abdominis was basically completely atrophic,and the epithelialization was good.Acrylic fixed bridge restoration was successful,the good rate of function recovery was 97.9%.After 6 weeks of operation,the underjaw was detected using the conventional submandibular CT scan,and the 3D reconstruction of which was implemented.The new bone was obvious,and the new bone was identified in the center and edge of defect.After 8 weeks of operation,the defect had been completely restored.Conclusions:The ectopic bone of adipose-derived stem cells in the repair of large area defect of maxillary has no obvious rejection reaction,which is worthy of clinical application.
Objective:To investigate the clinical effects of the ectopic bone of adipose-derived stem cells in the repair of large area defect of maxillary.Methods:The maxillary defect model of rabbit was established,and the defect was repaired with ectopic bone of autologous adipose-derived stem cells.The repair effect was observed using biopsy and imaging examination.Results:The biopsy results showed that the new bone tissue vascularization was good and mature bone tissue structure.After 2 months of reconstruction,the rectus abdominis was basically completely atrophic,and the epithelialization was good.Acrylic fixed bridge restoration was successful,the good rate of function recovery was 97.9%.After 6 weeks of operation,the underjaw was detected using the conventional submandibular CT scan,and the 3D reconstruction of which was implemented.The new bone was obvious,and the new bone was identified in the center and edge of defect.After 8 weeks of operation,the defect had been completely restored.Conclusions:The ectopic bone of adipose-derived stem cells in the repair of large area defect of maxillary has no obvious rejection reaction,which is worthy of clinical application.
2018, 43(6): 707-709.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.003
Abstract:
Objective:To investigate the effects of hypoxic post-treatment on neonatal rats with hypoxic-ischemic brain damage.Methods:Two hundred and four SD rats were randomly divided into the HIBD group,sham operation group,8% O2 combined with 92% N2 group(hypoxic group A),and 15% O2 combined with 85% N2 group(hypoxic group B)(51 rats each group).The levels of hypoxia inducible factor(HIF)-1α and learning and memory abilities between four groups were compared.Results:The differences of the levels of HIF-1α in brain tissue between four groups were statistically significant(P<0.01),the level of HIF-1α expression in hypoxic group A was the highest,which gradually decreased in hypoxia group B,sham operation group,and HIBD group in turn.There were statistical significances in the study latency,memory latency,and number of learning errors and memory errors between four groups(P<0.01),the four indictors in sham operation group were significantly better than those in other three groups(P<0.01),the memory latency and number of learning errors in hypoxia group A and hypoxia group B were significantly less than those in HIBD group(P<0.05 to P<0.01),and the study latency in hypoxia group A was less than that in HIBD group(P<0.05).Conclusions:The hypoxic post-treatment in neonatal rats with hypoxic-ischemic brain damage can effectively promote the expression of HIF-1α,and enhance the learning and memory abilities of newborn rats.
Objective:To investigate the effects of hypoxic post-treatment on neonatal rats with hypoxic-ischemic brain damage.Methods:Two hundred and four SD rats were randomly divided into the HIBD group,sham operation group,8% O2 combined with 92% N2 group(hypoxic group A),and 15% O2 combined with 85% N2 group(hypoxic group B)(51 rats each group).The levels of hypoxia inducible factor(HIF)-1α and learning and memory abilities between four groups were compared.Results:The differences of the levels of HIF-1α in brain tissue between four groups were statistically significant(P<0.01),the level of HIF-1α expression in hypoxic group A was the highest,which gradually decreased in hypoxia group B,sham operation group,and HIBD group in turn.There were statistical significances in the study latency,memory latency,and number of learning errors and memory errors between four groups(P<0.01),the four indictors in sham operation group were significantly better than those in other three groups(P<0.01),the memory latency and number of learning errors in hypoxia group A and hypoxia group B were significantly less than those in HIBD group(P<0.05 to P<0.01),and the study latency in hypoxia group A was less than that in HIBD group(P<0.05).Conclusions:The hypoxic post-treatment in neonatal rats with hypoxic-ischemic brain damage can effectively promote the expression of HIF-1α,and enhance the learning and memory abilities of newborn rats.
Study on the factors influencing the clinical prognosis of patients with top of the basilar syndrome
2018, 43(6): 710-712.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.004
Abstract:
Objective:To explore the factors influencing the clinical prognosis of patients with top of the basilar syndrome(TOBS).Methods:A total of 50 patients with TOBS were divided into the favorable outcome group(MRS 0-3) and unfavorable outcome group(MRS 4-6) according to the MRS after 30 d of onset.The general information on admission,imaging findings,National Institutes of Health Stroke Scale(NIHSS) score and Glasgow Coma Scale(GCS) score between two groups were compared.Results:The difference of the pathogenesis between two groups was statistically significant(P<0.01),and the embolism was the main pathogenesis in unfavorable outcome group(82.1%).The difference of the lesion location between two groups was statistically significant(P<0.01),and the mix lesion was the main in unfavorable outcome group(71.4%).The NIHSS score and GCS score in unfavorable outcome group were significantly higher and lower than that in favorable outcome group,respectively(P<0.01).Conclusions:The clinical prognosis in patients with embolism,upper and lower tentoriums cerelelli involved are poor.The diagnosis and treatment plan should be optimized to reduce the fatality rate of TOBS handicap.The combined score of NIHSS and GCS may effectively evaluate the disease and prognosis of TOBS.
Objective:To explore the factors influencing the clinical prognosis of patients with top of the basilar syndrome(TOBS).Methods:A total of 50 patients with TOBS were divided into the favorable outcome group(MRS 0-3) and unfavorable outcome group(MRS 4-6) according to the MRS after 30 d of onset.The general information on admission,imaging findings,National Institutes of Health Stroke Scale(NIHSS) score and Glasgow Coma Scale(GCS) score between two groups were compared.Results:The difference of the pathogenesis between two groups was statistically significant(P<0.01),and the embolism was the main pathogenesis in unfavorable outcome group(82.1%).The difference of the lesion location between two groups was statistically significant(P<0.01),and the mix lesion was the main in unfavorable outcome group(71.4%).The NIHSS score and GCS score in unfavorable outcome group were significantly higher and lower than that in favorable outcome group,respectively(P<0.01).Conclusions:The clinical prognosis in patients with embolism,upper and lower tentoriums cerelelli involved are poor.The diagnosis and treatment plan should be optimized to reduce the fatality rate of TOBS handicap.The combined score of NIHSS and GCS may effectively evaluate the disease and prognosis of TOBS.
2018, 43(6): 713-716.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.005
Abstract:
Objective:To assess the diagnostic value of DNA quantitative analysis in early screening of cervical lesions,and investigate its clinical significance in cytology of atypical squamous cells of undetermined significance(ASCUS).Methods:The thinprep cytology test(TCT) and cell DNA quantitative analysis were implemented in 1 980 cervical census from January 2015 and December 2016.The biopsies under colposcopy in 241 cases were detected.Under the histological diagnosis being set as the gold standard,the diagnostic value of DNA quantitative analysis and its clinical significance in cytology of ASCUS were evaluated.Results:Among 241 cases,7 cases in normal DNA ploidy group(128 cases),7 cases in heteroploid cell group(54 cases) and 30 cases in equal to or more than 3 heteroploid cell group(59 cases) were diagnosed for cervical intraepithelial neoplasia grade 2(CIN Ⅱ),respectively.The results of DNA ploidy analysis and histopathology showed that the lesion grade was positively correlated with the abnormal DNA ploidy number(rs=0.439,P<0.01),the sensibility and specificity of which were 84.1% and 61.4%,respectively.Among 57 cases with ASCUS,1 to 2 abnormal DNA ploidy cells in 8 cases, ≥ 3 abnormal DNA ploidy cells in 28 cases and normal DNA ploidy cell in 21 cases were identified.The cases of grade CIN Ⅱ and above in three groups were 1 case,13 cases and 1 case,respectively.The histopathology grade in ASCUS patients complicated with abnormal DNA ploidy was positively correlated with the abnormal DNA ploidy(rs=0.424,P<0.01).Conclusions:DNA quantitative detection can improve the early screening rate of the cervical lesions,the risk of CIN Ⅱ or above in ASCUS patients complicated with heteroploid cell is the highest.The combination of DNA quantitative analysis and cytology can improve the screening quality to guide the clinical treatment.
Objective:To assess the diagnostic value of DNA quantitative analysis in early screening of cervical lesions,and investigate its clinical significance in cytology of atypical squamous cells of undetermined significance(ASCUS).Methods:The thinprep cytology test(TCT) and cell DNA quantitative analysis were implemented in 1 980 cervical census from January 2015 and December 2016.The biopsies under colposcopy in 241 cases were detected.Under the histological diagnosis being set as the gold standard,the diagnostic value of DNA quantitative analysis and its clinical significance in cytology of ASCUS were evaluated.Results:Among 241 cases,7 cases in normal DNA ploidy group(128 cases),7 cases in heteroploid cell group(54 cases) and 30 cases in equal to or more than 3 heteroploid cell group(59 cases) were diagnosed for cervical intraepithelial neoplasia grade 2(CIN Ⅱ),respectively.The results of DNA ploidy analysis and histopathology showed that the lesion grade was positively correlated with the abnormal DNA ploidy number(rs=0.439,P<0.01),the sensibility and specificity of which were 84.1% and 61.4%,respectively.Among 57 cases with ASCUS,1 to 2 abnormal DNA ploidy cells in 8 cases, ≥ 3 abnormal DNA ploidy cells in 28 cases and normal DNA ploidy cell in 21 cases were identified.The cases of grade CIN Ⅱ and above in three groups were 1 case,13 cases and 1 case,respectively.The histopathology grade in ASCUS patients complicated with abnormal DNA ploidy was positively correlated with the abnormal DNA ploidy(rs=0.424,P<0.01).Conclusions:DNA quantitative detection can improve the early screening rate of the cervical lesions,the risk of CIN Ⅱ or above in ASCUS patients complicated with heteroploid cell is the highest.The combination of DNA quantitative analysis and cytology can improve the screening quality to guide the clinical treatment.
2018, 43(6): 717-718,722.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.006
Abstract:
Objective:To investigate the clinical effects of nano-carbon suspension in cleaning the central lymph nodes in papillary thyroid carcinoma.Methods:Forty patients with papillary thyroid carcinoma were randomly divided into the observation group and control group by the random number table method(20 cases each group).The observation group and control group were treated with and without nano-carbon suspension,respectively.The lymph node dissection condition and parathyroid hormone level between two groups were compared.Results:Two hundred and twenty-one lymph nodes were dissected in observation group,and the staining rate of lymph node in observation group was 96.67%.One hundred and sixty-five lymph nodes were dissected in control group.The ratio of positive lymph node,ratio of lymph node with diameter <0.3 cm,average detection rate of lymph node in observation group were higher than those in control group(P<0.01).There was no statistical significance in the preoperative serum levels of calcium and parathyroid hormone between two groups(P>0.05).After 1 day of operation,the serum levels of parathyroid hormone in two groups and calcium level in control group decreased compared with before operation(P<0.05 to P<0.01),and the serum levels of calcium and parathyroid hormone in observation group were significantly higher than those in control group(P<0.01).Conclusions:The application of nano-carbon suspension in cleaning the central lymph node of papillary thyroid carcinoma can improve the completeness of cleaning,protect the parathyroid gland function,which is worthy of promotion.
Objective:To investigate the clinical effects of nano-carbon suspension in cleaning the central lymph nodes in papillary thyroid carcinoma.Methods:Forty patients with papillary thyroid carcinoma were randomly divided into the observation group and control group by the random number table method(20 cases each group).The observation group and control group were treated with and without nano-carbon suspension,respectively.The lymph node dissection condition and parathyroid hormone level between two groups were compared.Results:Two hundred and twenty-one lymph nodes were dissected in observation group,and the staining rate of lymph node in observation group was 96.67%.One hundred and sixty-five lymph nodes were dissected in control group.The ratio of positive lymph node,ratio of lymph node with diameter <0.3 cm,average detection rate of lymph node in observation group were higher than those in control group(P<0.01).There was no statistical significance in the preoperative serum levels of calcium and parathyroid hormone between two groups(P>0.05).After 1 day of operation,the serum levels of parathyroid hormone in two groups and calcium level in control group decreased compared with before operation(P<0.05 to P<0.01),and the serum levels of calcium and parathyroid hormone in observation group were significantly higher than those in control group(P<0.01).Conclusions:The application of nano-carbon suspension in cleaning the central lymph node of papillary thyroid carcinoma can improve the completeness of cleaning,protect the parathyroid gland function,which is worthy of promotion.
2018, 43(6): 719-722.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.007
Abstract:
Objective:To explore the clinical efficacy and toxicity of pemetrexed or gemcitabine combined with cisplatin in the treatment of patients with advanced non-small cell lung cancer(NSCLC).Methods:Among 46 patients with advanced NSCLC,22 cases were treated with pemetrexed combined with cisplatin(pemetrexed group) and 24 cases were treated with gemcitabine combined with cisplatin(gemcitabine group).The short-term efficacy,median disease-free progression survival(PFS) time and adverse reactions between two groups were compared.Results:The objective remission rate,disease control rate and median PFS in pemetrexed group and gemcitabine group were(36.4% and 29.2%),(62.5% and 45.8%),and(6.5 and 6.0 months),respectively,and the differences of the objective remission rate,disease control rate and median PFS between two groups were not statistically significant(P>0.05).The adverse reactions in two groups were tolerable.The rates of neutrophil reduction in pemetrexed group and gemcitabine group were 36.4%(8/22) and 66.7%(16/24),respectively,and the difference of which between two groups was statistically significant(P<0.05).Conclusions:The clinical effect between pemetrexed combined with cisplatin and gemcitabine combined with cisplatin in the treatment of advanced NSCLC is similar,but the pemetrexed combined with cisplatin is less toxicities,good tolerability,worthy of application.
Objective:To explore the clinical efficacy and toxicity of pemetrexed or gemcitabine combined with cisplatin in the treatment of patients with advanced non-small cell lung cancer(NSCLC).Methods:Among 46 patients with advanced NSCLC,22 cases were treated with pemetrexed combined with cisplatin(pemetrexed group) and 24 cases were treated with gemcitabine combined with cisplatin(gemcitabine group).The short-term efficacy,median disease-free progression survival(PFS) time and adverse reactions between two groups were compared.Results:The objective remission rate,disease control rate and median PFS in pemetrexed group and gemcitabine group were(36.4% and 29.2%),(62.5% and 45.8%),and(6.5 and 6.0 months),respectively,and the differences of the objective remission rate,disease control rate and median PFS between two groups were not statistically significant(P>0.05).The adverse reactions in two groups were tolerable.The rates of neutrophil reduction in pemetrexed group and gemcitabine group were 36.4%(8/22) and 66.7%(16/24),respectively,and the difference of which between two groups was statistically significant(P<0.05).Conclusions:The clinical effect between pemetrexed combined with cisplatin and gemcitabine combined with cisplatin in the treatment of advanced NSCLC is similar,but the pemetrexed combined with cisplatin is less toxicities,good tolerability,worthy of application.
2018, 43(6): 723-725.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.008
Abstract:
Objective:To explore the relationship between neck artery tortuosity and cognitive dysfunction.Methods:One hundred and sixty-two patients detected by CT angiography of head and neck were selected.The cognitive function of patients was evaluated using the Montreal Intelligence Scale.The number of neck artery tortuosity was calculated.The relationship between neck artery tortuosity and cognitive dysfunction was analyzed.Results:Compared with normal people,the incidence rate of neck artery tortuosity was significantly higher in patients with cognitive dysfunction(P<0.01).Logistic regression analysis indicated that the age and neck artery tortuosity were the risk factors of cognitive dysfunction(P<0.01),but the vertebral artery tortuosity was unrelated to the cognitive dysfunction(P>0.05).The Pearson correlation analysis showed that the cognitive dysfunction score was negatively correlated with the neck artery tortuosity number(r=-0.618,P<0.05).Conclusions:Neck artery tortuosity may be the independent risk factor of cognitive dysfunction.
Objective:To explore the relationship between neck artery tortuosity and cognitive dysfunction.Methods:One hundred and sixty-two patients detected by CT angiography of head and neck were selected.The cognitive function of patients was evaluated using the Montreal Intelligence Scale.The number of neck artery tortuosity was calculated.The relationship between neck artery tortuosity and cognitive dysfunction was analyzed.Results:Compared with normal people,the incidence rate of neck artery tortuosity was significantly higher in patients with cognitive dysfunction(P<0.01).Logistic regression analysis indicated that the age and neck artery tortuosity were the risk factors of cognitive dysfunction(P<0.01),but the vertebral artery tortuosity was unrelated to the cognitive dysfunction(P>0.05).The Pearson correlation analysis showed that the cognitive dysfunction score was negatively correlated with the neck artery tortuosity number(r=-0.618,P<0.05).Conclusions:Neck artery tortuosity may be the independent risk factor of cognitive dysfunction.
2018, 43(6): 726-729,733.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.009
Abstract:
Objective:To investigate the correlation of magnetic resonance diffusion tensor imaging(DTI) after diffuse axonal injury(DAI) with cognitive function at recovery stage.Methods:Eighteen patients with DAI(DAI group) were early examined using DTI,and the result of which was compared with that of 16 heathy volunteers(control group).DTI was processed using Track and MRIcron software,the fractional anisotropy(FA) and apparent diffusion coefficient(ADC) value were quantified from different regions of interest(ROI) area,and the FA and ADC value between DAI group and control group were compared.The DAI patients at recovery stage[post-injury (17.26±4.31) months] were assessed using the cognition scale,the result of which was compared with that of control group with similar education.The contents of cognition scale included the digital back test of Wechsler adult intelligence scale(Hunan version),California speech learning scale,wired test and Stroop color-word test.The difference of the cognition function between two groups was compared.The correlation between DTI parameter and cognition scale score was analyzed using the Pearson linear correlation in DAI group.Results:At early stage of DAI,the FA value in all ROI areas in DAI group were significantly lower than that in control group(P<0.01),the ADC values of fasciculus uncinatus and fasciculi longitudinalis inferior in DAI group were higher than those in control group(P<0.05),and the difference of the ADC in other ROI area was not statistically significant(P>0.05).At recovery stage,the scores of the digital back test,California speech learning scale,short-term free and clue recall scales in DAI group decreased compared with control group(P<0.01),and the scores of the wired test,and Stroop color-word test 1,2 and 3 in DAI group increased compared with control group(P<0.05 to P<0.01).The FA value in uncinate fasciculus,anterior corona radiata,superior longitudinal fasciculus and inferior longitudinal fasciculus was significantly correlated with the total scores of working memory and executive function scale in DAI group(P<0.01 and P<0.05),but the ADC value in ROIs was not significantly correlated with the total scores of working memory and executive function scale in DAI group(P>0.05).Conclusions:Early magnetic resonance DTI detection in DAI patients is helpful to predict different types of cognitive dysfunction during the recovery,which can provide a theoretical basis for the early diagnosis and treatment of patients.
Objective:To investigate the correlation of magnetic resonance diffusion tensor imaging(DTI) after diffuse axonal injury(DAI) with cognitive function at recovery stage.Methods:Eighteen patients with DAI(DAI group) were early examined using DTI,and the result of which was compared with that of 16 heathy volunteers(control group).DTI was processed using Track and MRIcron software,the fractional anisotropy(FA) and apparent diffusion coefficient(ADC) value were quantified from different regions of interest(ROI) area,and the FA and ADC value between DAI group and control group were compared.The DAI patients at recovery stage[post-injury (17.26±4.31) months] were assessed using the cognition scale,the result of which was compared with that of control group with similar education.The contents of cognition scale included the digital back test of Wechsler adult intelligence scale(Hunan version),California speech learning scale,wired test and Stroop color-word test.The difference of the cognition function between two groups was compared.The correlation between DTI parameter and cognition scale score was analyzed using the Pearson linear correlation in DAI group.Results:At early stage of DAI,the FA value in all ROI areas in DAI group were significantly lower than that in control group(P<0.01),the ADC values of fasciculus uncinatus and fasciculi longitudinalis inferior in DAI group were higher than those in control group(P<0.05),and the difference of the ADC in other ROI area was not statistically significant(P>0.05).At recovery stage,the scores of the digital back test,California speech learning scale,short-term free and clue recall scales in DAI group decreased compared with control group(P<0.01),and the scores of the wired test,and Stroop color-word test 1,2 and 3 in DAI group increased compared with control group(P<0.05 to P<0.01).The FA value in uncinate fasciculus,anterior corona radiata,superior longitudinal fasciculus and inferior longitudinal fasciculus was significantly correlated with the total scores of working memory and executive function scale in DAI group(P<0.01 and P<0.05),but the ADC value in ROIs was not significantly correlated with the total scores of working memory and executive function scale in DAI group(P>0.05).Conclusions:Early magnetic resonance DTI detection in DAI patients is helpful to predict different types of cognitive dysfunction during the recovery,which can provide a theoretical basis for the early diagnosis and treatment of patients.
Correlation study of the serum level of AMH with clinical endocrine indicators in patients with PCOS
2018, 43(6): 730-733.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.010
Abstract:
Objective:To explore the correlations of the serum level of anti-Mullerian hormone(AMH) and sex hormone with endocrine and metabolism indicators in patients with infertility polycystic ovary syndrome(PCOS).Methods:Seventy-one patients with infertility PCOS and 50 normal physical examination women were divided into the observation group and control group,respectively.The correlations of the levels of BMI,serum AMH,FSH,LH,T,E2,FINS,GLU,CHOL,TG,LDL,HOMA-IR and number of 2-9mm follicles in both ovaries in two groups were analyzed.Results:The levels of BMI,serum AMH,LH,T,GLU,FINS,HOMR-IR and number of 2-9mm follicles in observation group were higher than those in control group(P<0.01).Pearson correlation analysis showed that the AMH level was positively correlated with T and PCO(P<0.01),and without other variables(P>0.05).The multiple linear analysis showed that T and PCO influenced the serum AMH level(P<0.01).Conclusions:The T and PCO are the influencing factors of serum AMH level.
Objective:To explore the correlations of the serum level of anti-Mullerian hormone(AMH) and sex hormone with endocrine and metabolism indicators in patients with infertility polycystic ovary syndrome(PCOS).Methods:Seventy-one patients with infertility PCOS and 50 normal physical examination women were divided into the observation group and control group,respectively.The correlations of the levels of BMI,serum AMH,FSH,LH,T,E2,FINS,GLU,CHOL,TG,LDL,HOMA-IR and number of 2-9mm follicles in both ovaries in two groups were analyzed.Results:The levels of BMI,serum AMH,LH,T,GLU,FINS,HOMR-IR and number of 2-9mm follicles in observation group were higher than those in control group(P<0.01).Pearson correlation analysis showed that the AMH level was positively correlated with T and PCO(P<0.01),and without other variables(P>0.05).The multiple linear analysis showed that T and PCO influenced the serum AMH level(P<0.01).Conclusions:The T and PCO are the influencing factors of serum AMH level.
2018, 43(6): 734-736,740.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.011
Abstract:
Objective:To observe the effectiveness and safety of nerve block combined with interference electrotherapy in the treatment of postherpetic neuralgia(PHN).Methods:Sixty patients with PHN were randomly divided into the control group and observation group(30 cases each group).The control group was treated with oral pregabalin combined with corresponding intercostal nerve block,and the observation group was treated with oral pregabalin combined with corresponding intercostal nerve block and interference electrotherapy for 8 weeks.The visual analogue scale(VAS),and sleep quality score(QS) in two groups between before and after treatment were compared.Results:After treatment,the VAS score and QS score in two groups significantly decreased compared with before treatment(P<0.01),and the decreasing degrees of VAS score and QS score in observation group were more obvious than those in control group(P<0.01).The total effective rates in two groups were 100%,but the marked effect case in observation group was more than that in control group(P<0.05).Conclusions:Nerve block combined with interference electrotherapy can effectively relieve or remove the pain in PHN patients,which is simple,feasible,safe,and worthy of clinical application and promotion.
Objective:To observe the effectiveness and safety of nerve block combined with interference electrotherapy in the treatment of postherpetic neuralgia(PHN).Methods:Sixty patients with PHN were randomly divided into the control group and observation group(30 cases each group).The control group was treated with oral pregabalin combined with corresponding intercostal nerve block,and the observation group was treated with oral pregabalin combined with corresponding intercostal nerve block and interference electrotherapy for 8 weeks.The visual analogue scale(VAS),and sleep quality score(QS) in two groups between before and after treatment were compared.Results:After treatment,the VAS score and QS score in two groups significantly decreased compared with before treatment(P<0.01),and the decreasing degrees of VAS score and QS score in observation group were more obvious than those in control group(P<0.01).The total effective rates in two groups were 100%,but the marked effect case in observation group was more than that in control group(P<0.05).Conclusions:Nerve block combined with interference electrotherapy can effectively relieve or remove the pain in PHN patients,which is simple,feasible,safe,and worthy of clinical application and promotion.
2018, 43(6): 737-740.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.012
Abstract:
Objective:To investigate the clinical efficacy of irbesartan in the treatment of early renal damage of hypertension.Methods:Eighty hypertensive patients with early renal damage were randomly divided into the amlodipine group and irbesartan group(40 cases each group).The amlodipine group and irbesartan group were treated with amlodipine and irbesartan,respectively.After 12 weeks of treatment,the blood pressure,renal function and vascular endothelial function were compared between two groups.Results:The systolic blood pressure,diastolic blood pressure and mean arterial pressure in two groups after treatment were significantly lower than before treatment(P<0.01),there was no statistical significance between two groups(P>0.05).The levels of 24 h UAER and β2-MG in irbesartan group were significantly lower than those in amlodipine group,the NO and vascular endothelial function in irbesartan group were significantly higher than those in amlodipine group,and the ET level in irbesartan group was significantly lower than that in amlodipine group(P<0.05 to P<0.01).The difference of the incidence rate of adverse reaction between two groups was not statistically significant(P>0.05).Conclusions:Irbesartan and amlodipine can effectively reduce the blood pressure in hypertension patients with early renal damage.The effect of irbesartan in improving renal and vascular endothelial function is better than that of amlodipine,and the use of irbesartan is worthy of attention.
Objective:To investigate the clinical efficacy of irbesartan in the treatment of early renal damage of hypertension.Methods:Eighty hypertensive patients with early renal damage were randomly divided into the amlodipine group and irbesartan group(40 cases each group).The amlodipine group and irbesartan group were treated with amlodipine and irbesartan,respectively.After 12 weeks of treatment,the blood pressure,renal function and vascular endothelial function were compared between two groups.Results:The systolic blood pressure,diastolic blood pressure and mean arterial pressure in two groups after treatment were significantly lower than before treatment(P<0.01),there was no statistical significance between two groups(P>0.05).The levels of 24 h UAER and β2-MG in irbesartan group were significantly lower than those in amlodipine group,the NO and vascular endothelial function in irbesartan group were significantly higher than those in amlodipine group,and the ET level in irbesartan group was significantly lower than that in amlodipine group(P<0.05 to P<0.01).The difference of the incidence rate of adverse reaction between two groups was not statistically significant(P>0.05).Conclusions:Irbesartan and amlodipine can effectively reduce the blood pressure in hypertension patients with early renal damage.The effect of irbesartan in improving renal and vascular endothelial function is better than that of amlodipine,and the use of irbesartan is worthy of attention.
2018, 43(6): 741-744,748.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.013
Abstract:
Objective:To analyze the effects of propofol anesthesia on the levels of cortisol(Cor) and blood glucose in female patients treated with minimally invasive surgery.Methods:Sixty patients treated with laparoscopic myomectomy were divided into the sevoflurane group(n=30) and propofol group(n=30) according to the random number table method.After anesthesia induction,the sevoflurane was inhaled in sevoflurane group,and the propofol was infused in propofol group.The levels of mean arterial pressure(MAP),heart rate(HR),cortisol(Cor),blood glucose,insulin,C peptide,glucagon(Glu) between two groups were compared at the establishment of pneumoperitoneum(T1) and after 10 min and 30 min of pneumoperitoneum(T2 and T3) and during surgery(T4).Results:The differences of the anesthesia time,opening eye time,operation time and awaking time between two groups were not statistically significant(P>0.05).The differences of the anesthesia time,opening eye time,operation time and awaking time between two groups were not statistically significant(P>0.05).The differences of the amount of colloidal fluid,total fluid infusion volume,number of vasoactive drug use and amount of opioid use between two groups were not statistically significant(P>0.05).The differences of the levels of MAP and HR between two groups at different time-points were not statistically significant(P>0.05).The levels of Cor,blood glucose,insulin,C peptide and Glu in two groups at T2,T3 and T4 were higher than those at T1(P<0.05 to P<0.01).At T1,the differences of the levels of Cor,blood glucose,insulin,C peptide and Glu between two groups were not statistically significant(P>0.05).At T2,the levels of blood glucose and Glu in propofol group were lower than those in sevoflurane group,and the level of C peptide in propofol group was higher than that in sevoflurane group(P<0.05).At T3 and T4,the levels of Cor,blood glucose and Glu in propofol group were lower than those in sevoflurane group,and the levels of insulin and C peptide in propofol group were higher than that in sevoflurane group(P<0.05 to P<0.01).Conclusions:Propofol and sevoflurane can effectively maintain the stabilization of hemodynamics in patients treated with laparoscopic myomectomy.The propofol can promote the secretion of C peptide and insulin,and inhibit the excessive secretion of Glu,Cor and hyperglycemia during operation.Compared with sevoflurane,the effect of propofol on reducing the intraoperative stress response is better.
Objective:To analyze the effects of propofol anesthesia on the levels of cortisol(Cor) and blood glucose in female patients treated with minimally invasive surgery.Methods:Sixty patients treated with laparoscopic myomectomy were divided into the sevoflurane group(n=30) and propofol group(n=30) according to the random number table method.After anesthesia induction,the sevoflurane was inhaled in sevoflurane group,and the propofol was infused in propofol group.The levels of mean arterial pressure(MAP),heart rate(HR),cortisol(Cor),blood glucose,insulin,C peptide,glucagon(Glu) between two groups were compared at the establishment of pneumoperitoneum(T1) and after 10 min and 30 min of pneumoperitoneum(T2 and T3) and during surgery(T4).Results:The differences of the anesthesia time,opening eye time,operation time and awaking time between two groups were not statistically significant(P>0.05).The differences of the anesthesia time,opening eye time,operation time and awaking time between two groups were not statistically significant(P>0.05).The differences of the amount of colloidal fluid,total fluid infusion volume,number of vasoactive drug use and amount of opioid use between two groups were not statistically significant(P>0.05).The differences of the levels of MAP and HR between two groups at different time-points were not statistically significant(P>0.05).The levels of Cor,blood glucose,insulin,C peptide and Glu in two groups at T2,T3 and T4 were higher than those at T1(P<0.05 to P<0.01).At T1,the differences of the levels of Cor,blood glucose,insulin,C peptide and Glu between two groups were not statistically significant(P>0.05).At T2,the levels of blood glucose and Glu in propofol group were lower than those in sevoflurane group,and the level of C peptide in propofol group was higher than that in sevoflurane group(P<0.05).At T3 and T4,the levels of Cor,blood glucose and Glu in propofol group were lower than those in sevoflurane group,and the levels of insulin and C peptide in propofol group were higher than that in sevoflurane group(P<0.05 to P<0.01).Conclusions:Propofol and sevoflurane can effectively maintain the stabilization of hemodynamics in patients treated with laparoscopic myomectomy.The propofol can promote the secretion of C peptide and insulin,and inhibit the excessive secretion of Glu,Cor and hyperglycemia during operation.Compared with sevoflurane,the effect of propofol on reducing the intraoperative stress response is better.
2018, 43(6): 745-748.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.014
Abstract:
Objective:To investigate the effects of high dose atorvastatin on blood endothelial progenitor cells(EPCs) mobilization,and expression levels of vascular endothelial growth factor(VEGF) and toll like receptor 4(TLR4) in acute myocardial infarction(AMI) patients treated with percutaneous coronary intervention(PCI).Methods:One hundred emergency patients with AMI were randomly divided into the high dose group and conventional dose group(50 cases each group),and 50 patients with non-organic heart disease were set as the control group.The levels of EPCs,VEGF and TLR4 in three groups were analyzed.Results:After treatment,the EPCs amount and VEGF level in high dose group were significantly higher than those in conventional dose group(P<0.05 to P<0.01),and the level of TLR4 in high dose group was significantly lower than that in conventional dose group(P<0.01).Compared with before treatment,the EPCs amount and VEGF level significantly increased(P<0.01),and the level of TLR4 significantly decreased in high dose group(P<0.01).Compared with before treatment,the level of TLR4 significantly decreased(P<0.01),and the changes of the EPCs amount and VEGF level were not obvious in conventional dose group(P>0.05).After tre atment,the differences of the incidence rate of MVA and increasing rate of alanine aminotransferase between high dose group and conventional dose group were not statistically significant(P>0.05).Conclusions:High dose atorvastatin can increase the VEGF expression,mobilize bone marrow EPCs to repair the vascular intima,reduce TLR4 expression in peripheral blood monocytes,and play a role in inhibiting inflammation and stabilizing plaque.
Objective:To investigate the effects of high dose atorvastatin on blood endothelial progenitor cells(EPCs) mobilization,and expression levels of vascular endothelial growth factor(VEGF) and toll like receptor 4(TLR4) in acute myocardial infarction(AMI) patients treated with percutaneous coronary intervention(PCI).Methods:One hundred emergency patients with AMI were randomly divided into the high dose group and conventional dose group(50 cases each group),and 50 patients with non-organic heart disease were set as the control group.The levels of EPCs,VEGF and TLR4 in three groups were analyzed.Results:After treatment,the EPCs amount and VEGF level in high dose group were significantly higher than those in conventional dose group(P<0.05 to P<0.01),and the level of TLR4 in high dose group was significantly lower than that in conventional dose group(P<0.01).Compared with before treatment,the EPCs amount and VEGF level significantly increased(P<0.01),and the level of TLR4 significantly decreased in high dose group(P<0.01).Compared with before treatment,the level of TLR4 significantly decreased(P<0.01),and the changes of the EPCs amount and VEGF level were not obvious in conventional dose group(P>0.05).After tre atment,the differences of the incidence rate of MVA and increasing rate of alanine aminotransferase between high dose group and conventional dose group were not statistically significant(P>0.05).Conclusions:High dose atorvastatin can increase the VEGF expression,mobilize bone marrow EPCs to repair the vascular intima,reduce TLR4 expression in peripheral blood monocytes,and play a role in inhibiting inflammation and stabilizing plaque.
2018, 43(6): 749-752.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.015
Abstract:
Objective:To investigate the relationships between the levels of interleukin(IL)-6,IL-8,homocystine(Hcy) and cognitive function in patients with post-stroke depression.Methods:The cognitive abilities of 200 patients with post-stroke depression were detected using the mini-mental state examination(MMSE).The logic ST model was established by the backward iteration method for screening common susceptible factors.The correlations between the levels of IL-6,IL-8 and Hcy,and cognitive function were analyzed.Results:The gender,age,blood loss,depression time,intraoperative anesthetic dosage,intraoperative bleeding,operation time,discharge time,mental disease,bad living habit,and levels of IL-6,IL-8 and Hcy were associated with the cognitive function declining.The weighting coefficients of Hcy,IL-6 and IL-8 were higher(2.485,2.547 and 2.641,respectively).Conclusions:The levels of IL-6,IL-8 and Hcy in patients with post-stroke depression maybe play a certain role in cognitive declining.
Objective:To investigate the relationships between the levels of interleukin(IL)-6,IL-8,homocystine(Hcy) and cognitive function in patients with post-stroke depression.Methods:The cognitive abilities of 200 patients with post-stroke depression were detected using the mini-mental state examination(MMSE).The logic ST model was established by the backward iteration method for screening common susceptible factors.The correlations between the levels of IL-6,IL-8 and Hcy,and cognitive function were analyzed.Results:The gender,age,blood loss,depression time,intraoperative anesthetic dosage,intraoperative bleeding,operation time,discharge time,mental disease,bad living habit,and levels of IL-6,IL-8 and Hcy were associated with the cognitive function declining.The weighting coefficients of Hcy,IL-6 and IL-8 were higher(2.485,2.547 and 2.641,respectively).Conclusions:The levels of IL-6,IL-8 and Hcy in patients with post-stroke depression maybe play a certain role in cognitive declining.
2018, 43(6): 753-757.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.016
Abstract:
Objective:To investigate the effects of nalmefene hydrochloride in improving the postoperative resuscitation and analgesia in elderly patients with gastric cancer.Methods:Ninety elderly gastric cancer patients scheduled by operation were randomly divided into the control group,low-dose nalmefene group and high-dose nalmefene group(30 cases each group).The control group was intravenously injected with 2 mL normal saline at the end of surgery,and a PCIA analgesia pump(filling with 0.2 mg/kg butorphanol tartrate) were connected.The low-dose and nalmefene high-dose groups were intravenously injected with 0.25 and 0.50 μg/kg of nalmefene hydrochloride at the end of surgery,and a PCIA analgesia pump(filling with 0.2 mg/kg butorphanol tartrate and 2 μg/kg of nalmefene hydrochloride) were connected.The postoperative spontaneous breathing recovery time,eye opening time,extubation time,Narcotrend value and mental state(including conscious disturbance,agitation,and delirium) of patients between three groups were compared,and the VAS score,ramsay sedation score and postoperative nausea and vomiting(PONV) score between three groups were compared after 1,2,6,12,24 and 48 hours of operation.Results:The recovery time of spontaneous breathing,eye opening time and extubation time in high-dose group were significantly lower than those in low-dose group and control group(P<0.01),and which in low-dose group was significantly less than that in control group(P<0.01).The differences of the Narcotrend value between three groups at administration were not statistically significant(P>0.05),the Narcotrend values in high-dose group after 5,10 and 15 minutes of administration were significantly higher than those in low-dose group and control group(P<0.01),and the Narcotrend values in low-dose and high-dose groups after 20 minutes of administration were significantly higher than that in control group(P<0.01).The differences of the conscious disturbance,agitation,and delirium between three groups were not statistically significant(P>0.05).The VAS scores in high-dose group after 1 h and 48 h of operation were significantly lower than that in control group(P<0.01).The scores of Ramsay sedation and PONV in high-dose group after 1 h to 48 h of operation were significantly lower than that in control group(P<0.01).Conclusions:Nalmefene hydrochloride can effectively improve the postoperative recovery,and allivate the adverse reactions of opioid drug,which is worthy of promotion in clinic.
Objective:To investigate the effects of nalmefene hydrochloride in improving the postoperative resuscitation and analgesia in elderly patients with gastric cancer.Methods:Ninety elderly gastric cancer patients scheduled by operation were randomly divided into the control group,low-dose nalmefene group and high-dose nalmefene group(30 cases each group).The control group was intravenously injected with 2 mL normal saline at the end of surgery,and a PCIA analgesia pump(filling with 0.2 mg/kg butorphanol tartrate) were connected.The low-dose and nalmefene high-dose groups were intravenously injected with 0.25 and 0.50 μg/kg of nalmefene hydrochloride at the end of surgery,and a PCIA analgesia pump(filling with 0.2 mg/kg butorphanol tartrate and 2 μg/kg of nalmefene hydrochloride) were connected.The postoperative spontaneous breathing recovery time,eye opening time,extubation time,Narcotrend value and mental state(including conscious disturbance,agitation,and delirium) of patients between three groups were compared,and the VAS score,ramsay sedation score and postoperative nausea and vomiting(PONV) score between three groups were compared after 1,2,6,12,24 and 48 hours of operation.Results:The recovery time of spontaneous breathing,eye opening time and extubation time in high-dose group were significantly lower than those in low-dose group and control group(P<0.01),and which in low-dose group was significantly less than that in control group(P<0.01).The differences of the Narcotrend value between three groups at administration were not statistically significant(P>0.05),the Narcotrend values in high-dose group after 5,10 and 15 minutes of administration were significantly higher than those in low-dose group and control group(P<0.01),and the Narcotrend values in low-dose and high-dose groups after 20 minutes of administration were significantly higher than that in control group(P<0.01).The differences of the conscious disturbance,agitation,and delirium between three groups were not statistically significant(P>0.05).The VAS scores in high-dose group after 1 h and 48 h of operation were significantly lower than that in control group(P<0.01).The scores of Ramsay sedation and PONV in high-dose group after 1 h to 48 h of operation were significantly lower than that in control group(P<0.01).Conclusions:Nalmefene hydrochloride can effectively improve the postoperative recovery,and allivate the adverse reactions of opioid drug,which is worthy of promotion in clinic.
2018, 43(6): 757-759.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.017
Abstract:
Objective:To investigate the value of serum procalcitonin(PCT) and C-reactive protein(CRP) in the diagnosis of interstitial lung disease complicated with infection.Methods:A total of 98 patients with interstitial lung disease were divided into the infection group(54 cases complicated with infection) and uninfection group(44 cases complicated without infection).The serum levels of CRP,PCT,white blood cells(WBC),and neutrophil percentage(N%) were measured in two groups.Results:The differences of the levels of serum PCT and CRP between two groups were statistically significant(P<0.01),and the differences of the level of WBC and N% between two groups were not statistically significant(P>0.05).Correlation analysis showed that the levels of PCT and CRP were positively correlated with infection in patients with interstitial pneumonia(P<0.01 and P<0.05).The area under the ROC curve of the CRP and PCT in diagnosing interstitial pneumonia was significantly higher that of WBC and N%(P<0.01).Conclusions:The clinical value of PCT and CRP in the diagnosis of patients with interstitial lung disease complicated with infection is high,which can effectively judge the infection situation of patients with interstitial lung disease,and is worthy of promotion.
Objective:To investigate the value of serum procalcitonin(PCT) and C-reactive protein(CRP) in the diagnosis of interstitial lung disease complicated with infection.Methods:A total of 98 patients with interstitial lung disease were divided into the infection group(54 cases complicated with infection) and uninfection group(44 cases complicated without infection).The serum levels of CRP,PCT,white blood cells(WBC),and neutrophil percentage(N%) were measured in two groups.Results:The differences of the levels of serum PCT and CRP between two groups were statistically significant(P<0.01),and the differences of the level of WBC and N% between two groups were not statistically significant(P>0.05).Correlation analysis showed that the levels of PCT and CRP were positively correlated with infection in patients with interstitial pneumonia(P<0.01 and P<0.05).The area under the ROC curve of the CRP and PCT in diagnosing interstitial pneumonia was significantly higher that of WBC and N%(P<0.01).Conclusions:The clinical value of PCT and CRP in the diagnosis of patients with interstitial lung disease complicated with infection is high,which can effectively judge the infection situation of patients with interstitial lung disease,and is worthy of promotion.
2018, 43(6): 760-763.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.018
Abstract:
Objective:To compare the effects among the Kirschner wire fixation,steel plate fixation and elastic intramedullary nail intramedullary fixation in the treatment of proximal humerus fractures in older children.Methods:The clinical data of 150 older children with proximal humerus fractures from January 2010 to January 2016 were retrospectively analyzed.The patients were divided into the Kirschner wire group,steel plate group and intramedullary nail group according to the operation way.The differences of the operation time,intraoperative blood loss,incision length,hospitalization time,fracture healing time,Constant score,blood transfusion,excellent prognosis and incidence rate of complications among three groups were compared.Results:The operation time,intraoperative blood loss and incision length in plate group,Kirschner wire group and intramedullary nail group gradually decreased(P<0.01).The differences of the hospitalization time,fracture healing time,postoperative 1 and 3 months Constant scores,intraoperative blood transfusion,excellent rate of prognosis and incidence rate of complications among three groups were not statistically significant(P>0.05).Conclusions:Elastic intramedullary nail intramedullary fixation treatment has little operation time,intraoperative blood loss and incision length,and quick healing,which is an ideal treatment means,and worthy of promotion.
Objective:To compare the effects among the Kirschner wire fixation,steel plate fixation and elastic intramedullary nail intramedullary fixation in the treatment of proximal humerus fractures in older children.Methods:The clinical data of 150 older children with proximal humerus fractures from January 2010 to January 2016 were retrospectively analyzed.The patients were divided into the Kirschner wire group,steel plate group and intramedullary nail group according to the operation way.The differences of the operation time,intraoperative blood loss,incision length,hospitalization time,fracture healing time,Constant score,blood transfusion,excellent prognosis and incidence rate of complications among three groups were compared.Results:The operation time,intraoperative blood loss and incision length in plate group,Kirschner wire group and intramedullary nail group gradually decreased(P<0.01).The differences of the hospitalization time,fracture healing time,postoperative 1 and 3 months Constant scores,intraoperative blood transfusion,excellent rate of prognosis and incidence rate of complications among three groups were not statistically significant(P>0.05).Conclusions:Elastic intramedullary nail intramedullary fixation treatment has little operation time,intraoperative blood loss and incision length,and quick healing,which is an ideal treatment means,and worthy of promotion.
2018, 43(6): 764-768.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.019
Abstract:
Objective:To observe the clinical effects of novel hollow lag screw combined with titanium cable tension band in the minimally invasive treatment of patellar transverse fracture.Methods:Fifty patients with patellar transverse fractures was divided into the control group(23 cases) and observation group(27 cases) according to the different surgical procedures.The control group was treated with conventional cable-pin system minimally invasive surgery,and the observation group was treated with novel hollow lag screws combined with titanium cable tension band fixation.The operation situation,complication and knee function recovery between two groups were compared.Results:The incision and intraoperative bleeding volume,off-bed bearing time and fracture healing time in observation group were significantly less than those in control group(P<0.01).All patients were followed up for 12 to 27 months.The excellent rates of knee joint activity and knee joint recovery in observation group and control group were (96.30% and 100.00%) and (86.96% and 82.61%),respectively,and the difference of which was not statistically significant(P>0.05).One case with skin pricking and 1 case with infection in control group were found,and the difference of the incidence rate of complications between the control group(8.70%) and observation group(0.00%) was not statistically significant(P>0.05).Conclusions:The novel hollow lag screw combined with titanium cable tension band in the minimally invasive treatment of patellar transverse fracture has small incision,little bleeding and quick recovery,which can be used as one of the preferred type of operation,and is worthy of promotion and application in clinic.
Objective:To observe the clinical effects of novel hollow lag screw combined with titanium cable tension band in the minimally invasive treatment of patellar transverse fracture.Methods:Fifty patients with patellar transverse fractures was divided into the control group(23 cases) and observation group(27 cases) according to the different surgical procedures.The control group was treated with conventional cable-pin system minimally invasive surgery,and the observation group was treated with novel hollow lag screws combined with titanium cable tension band fixation.The operation situation,complication and knee function recovery between two groups were compared.Results:The incision and intraoperative bleeding volume,off-bed bearing time and fracture healing time in observation group were significantly less than those in control group(P<0.01).All patients were followed up for 12 to 27 months.The excellent rates of knee joint activity and knee joint recovery in observation group and control group were (96.30% and 100.00%) and (86.96% and 82.61%),respectively,and the difference of which was not statistically significant(P>0.05).One case with skin pricking and 1 case with infection in control group were found,and the difference of the incidence rate of complications between the control group(8.70%) and observation group(0.00%) was not statistically significant(P>0.05).Conclusions:The novel hollow lag screw combined with titanium cable tension band in the minimally invasive treatment of patellar transverse fracture has small incision,little bleeding and quick recovery,which can be used as one of the preferred type of operation,and is worthy of promotion and application in clinic.
2018, 43(6): 768-770.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.020
Abstract:
Objective:To investigate the effects of different surgical methods in the treatment of arteriovenous fistula on cardiac function in hemodialysis patients.Methods:Sixty uremic patients were treated with end-to-end arteriovenous fistula anastomosis(30 cases) and end-to-side arteriovenous fistula anastomosis(30 cases).The arteriovenous fistula and heart function in all patients were observed,and the effects of different surgical methods on cardiac function were evaluated.Results:The postoperative average blood flow and diameter in end-to-side anastomosis group were higher than those in end-to-end anastomosis group(P<0.01).After 1 year of operation,the cardiac index significantly increased,and the ejection fraction significantly decreased in end-to-side anastomosis group,and the differences of the cardiac index and ejection fraction between two groups were statistically significant(P<0.01).The difference of the incidence rate of the fistula failure between two groups was not statistically significant(P>0.05).Conclusions:The end-to-side anastomosis in the treatment of arteriovenous fistula in hemodialysis patients can ensure the blood flow,does not increase the heart load,which is worthy of promotion.
Objective:To investigate the effects of different surgical methods in the treatment of arteriovenous fistula on cardiac function in hemodialysis patients.Methods:Sixty uremic patients were treated with end-to-end arteriovenous fistula anastomosis(30 cases) and end-to-side arteriovenous fistula anastomosis(30 cases).The arteriovenous fistula and heart function in all patients were observed,and the effects of different surgical methods on cardiac function were evaluated.Results:The postoperative average blood flow and diameter in end-to-side anastomosis group were higher than those in end-to-end anastomosis group(P<0.01).After 1 year of operation,the cardiac index significantly increased,and the ejection fraction significantly decreased in end-to-side anastomosis group,and the differences of the cardiac index and ejection fraction between two groups were statistically significant(P<0.01).The difference of the incidence rate of the fistula failure between two groups was not statistically significant(P>0.05).Conclusions:The end-to-side anastomosis in the treatment of arteriovenous fistula in hemodialysis patients can ensure the blood flow,does not increase the heart load,which is worthy of promotion.
Expression NF-κB and serum amyloid A, and its correlation with lung function in children with asthma
2018, 43(6): 771-773,777.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.021
Abstract:
Objective:To investigate the correlation between the levels of nuclear factor-κB(NF-κB) and serum amyloid A(SAA),and lung function in children with asthma.Methods:Ninety-two children with bronchial asthma and 30 healthy children were divided into the asthma group and control group,respectively.The levels of NF-κB and SAA in two groups were detected using the protein immunoblotting and enzyme linked immunosorbent assay,respectively.The correlation between the levels of NF-κB and SAA,and lung function was investigated.Results:The levels of NF-κB and SAA in asthma group were significantly higher than those in control group(P<0.01),but the percentage of peak expiratory flow velocity to predicted value(PEF%),percentage of the 1st second force expiratory to predicted value(FEV1%) and FEV1/FVC in asthma group were significantly lower than those in control group(P<0.01).The levels of NF-κB and SAA in the asthma group were significantly negatively correlated with lung function indexes(PEF%,FEV1%,and FEV1/FVC) (P<0.01).Conclusions:NF-κB and SAA can play certain roles in the attack process of bronchial asthema by participating in the airway reconstruction and inflammatory reaction.
Objective:To investigate the correlation between the levels of nuclear factor-κB(NF-κB) and serum amyloid A(SAA),and lung function in children with asthma.Methods:Ninety-two children with bronchial asthma and 30 healthy children were divided into the asthma group and control group,respectively.The levels of NF-κB and SAA in two groups were detected using the protein immunoblotting and enzyme linked immunosorbent assay,respectively.The correlation between the levels of NF-κB and SAA,and lung function was investigated.Results:The levels of NF-κB and SAA in asthma group were significantly higher than those in control group(P<0.01),but the percentage of peak expiratory flow velocity to predicted value(PEF%),percentage of the 1st second force expiratory to predicted value(FEV1%) and FEV1/FVC in asthma group were significantly lower than those in control group(P<0.01).The levels of NF-κB and SAA in the asthma group were significantly negatively correlated with lung function indexes(PEF%,FEV1%,and FEV1/FVC) (P<0.01).Conclusions:NF-κB and SAA can play certain roles in the attack process of bronchial asthema by participating in the airway reconstruction and inflammatory reaction.
2018, 43(6): 774-777.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.022
Abstract:
Objective:To investigate the relationship between blood pressure variability and leukoaraiosis(LA) in elderly patients with essential hypertension.Methods:A total of 102 elderly patients with essential hypertension were divided into the LA group(75 cases) and Non-LA(27 cases) according to the MRI imaging.According to the Fazekas scale,the LA group were subdivided into the mild LA group(23 cases),moderate LA group(27 cases) and severe LA group(25 cases) according to the LA lesions.Non-invasive portable blood pressure monitor was used to monitor the 24h blood pressure.The blood lipid index,hypertension course,24 h SBP,daytime SBP,nighttime SBP,24 h DBP,daytime DBP and nighttime DBP and blood pressure variability between two groups were compared.Results:The differences of the age,sex,hypertension course,serum levels of TC,TG and LDL-C between the two groups were not statistically significant(P>0.05).The 24 h SBP and DBP,daytime SBP and DBP,and nighttime SBP and DBP in LA group were higher than those in Non-LA group(P<0.05 to P<0.01).The 24 h SBPV and DBPV,daytime SBPV and DBPV and nighttime SBPV and DBPV in LA group were higher than those in Non-LA group(P<0.05 to P<0.01).The difference of the BPV among LA subgroup was statistically significant(P<0.01).The BPV in severe group was higher than that in mild LA group(P<0.01).The average daytime systolic blood pressure variability in severe group was higher than that in moderate LA group(P<0.05),and the average nighttime systolic blood pressure variability in moderate group was higher than that in mild LA group(P<0.01).Conclusions:The blood pressure variability of elderly patients with essential hypertension is related to the occurrence and severity of LA.
Objective:To investigate the relationship between blood pressure variability and leukoaraiosis(LA) in elderly patients with essential hypertension.Methods:A total of 102 elderly patients with essential hypertension were divided into the LA group(75 cases) and Non-LA(27 cases) according to the MRI imaging.According to the Fazekas scale,the LA group were subdivided into the mild LA group(23 cases),moderate LA group(27 cases) and severe LA group(25 cases) according to the LA lesions.Non-invasive portable blood pressure monitor was used to monitor the 24h blood pressure.The blood lipid index,hypertension course,24 h SBP,daytime SBP,nighttime SBP,24 h DBP,daytime DBP and nighttime DBP and blood pressure variability between two groups were compared.Results:The differences of the age,sex,hypertension course,serum levels of TC,TG and LDL-C between the two groups were not statistically significant(P>0.05).The 24 h SBP and DBP,daytime SBP and DBP,and nighttime SBP and DBP in LA group were higher than those in Non-LA group(P<0.05 to P<0.01).The 24 h SBPV and DBPV,daytime SBPV and DBPV and nighttime SBPV and DBPV in LA group were higher than those in Non-LA group(P<0.05 to P<0.01).The difference of the BPV among LA subgroup was statistically significant(P<0.01).The BPV in severe group was higher than that in mild LA group(P<0.01).The average daytime systolic blood pressure variability in severe group was higher than that in moderate LA group(P<0.05),and the average nighttime systolic blood pressure variability in moderate group was higher than that in mild LA group(P<0.01).Conclusions:The blood pressure variability of elderly patients with essential hypertension is related to the occurrence and severity of LA.
2018, 43(6): 778-781.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.023
Abstract:
Objective:To investigate the effects of intensive glucose lowering combined with rosiglitazone on the levels of blood lipid and apolipoprotein in senile coronary heart disease(CHD) patients complicated with type 2 diabetes.Methods:Seventy-two senile CHD patients complicated with type 2 diabetes were randomly divided into the control group and observation group(36 cases each group).The control group and observation group were treated with intensive glucose lowering and intensive glucose lowering combined with rosiglitazone for 3 months,respectively.Two groups were followed up for 12 months.The clinical curative effect between two groups was compared,the blood lipid and apolipoprotein levels before and after treatment in two groups were detected,and the cardiovascular adverse events in two groups were observed during the following-up period.Results:After the treatment,the total effective rate in observation group(88.89%) was higher than that in control group(69.44%)(P<0.05),the levels of total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C) and apolipoprotein B(Apo B) in two groups decreased(P<0.05 to P<0.01),the levels of high density lipoprotein cholesterol(HDL-C) and apolipoprotein A1(Apo A1) in two groups increased(P<0.05 to P<0.01),and the decreasing degrees of the levels of TC,TG,LDL-C and Apo B,and increasing degrees of the levels of HDL-C and Apo A1 in observation group were higher than those in control group(P<0.05 to P<0.01).During the following-up,the incidence rate of adverse event in observation group(22.22%) was lower than that in control group(44.44%)(P<0.05).Conclusions:The intensive glucose lowering combined with rosiglitazone in the treatment of the senile CHD patients complicated with type 2 diabetes can significantly improve the levels of blood lipid and apolipoprotein,decrease the adverse event,and the effect of which is significant.
Objective:To investigate the effects of intensive glucose lowering combined with rosiglitazone on the levels of blood lipid and apolipoprotein in senile coronary heart disease(CHD) patients complicated with type 2 diabetes.Methods:Seventy-two senile CHD patients complicated with type 2 diabetes were randomly divided into the control group and observation group(36 cases each group).The control group and observation group were treated with intensive glucose lowering and intensive glucose lowering combined with rosiglitazone for 3 months,respectively.Two groups were followed up for 12 months.The clinical curative effect between two groups was compared,the blood lipid and apolipoprotein levels before and after treatment in two groups were detected,and the cardiovascular adverse events in two groups were observed during the following-up period.Results:After the treatment,the total effective rate in observation group(88.89%) was higher than that in control group(69.44%)(P<0.05),the levels of total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C) and apolipoprotein B(Apo B) in two groups decreased(P<0.05 to P<0.01),the levels of high density lipoprotein cholesterol(HDL-C) and apolipoprotein A1(Apo A1) in two groups increased(P<0.05 to P<0.01),and the decreasing degrees of the levels of TC,TG,LDL-C and Apo B,and increasing degrees of the levels of HDL-C and Apo A1 in observation group were higher than those in control group(P<0.05 to P<0.01).During the following-up,the incidence rate of adverse event in observation group(22.22%) was lower than that in control group(44.44%)(P<0.05).Conclusions:The intensive glucose lowering combined with rosiglitazone in the treatment of the senile CHD patients complicated with type 2 diabetes can significantly improve the levels of blood lipid and apolipoprotein,decrease the adverse event,and the effect of which is significant.
2018, 43(6): 784-788.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.025
Abstract:
Objective:To investigate the application value of CT three-dimensional reconstruction combined with 3D printing technology in atlantoaxial pedicle screw placement operation.Methods:Thirteen atlantoaxial? lesions patients diagnosed by post-processing methods of CT three-dimensional reconstruction were set as the observation group.A kind of new navigation template guiding the atlantoaxial pedicle screw placement operation was designed through CT three-dimensional reconstruction,principle of reverse engineering and rapid prototyping technology.Thirteen patients treated with pedicle screw fixation by X-ray fluoroscopy were set as the control group.The treatment effect between two groups was compared.Results:Forty-one pedicle screws in control group were implanted,which included 9 cases of level-I,18 cases of level-Ⅱ and 14 cases of level-Ⅲ pedicle screws,and the success rate of which was 65.9%.Twenty-one guiding templates were designed in observation group,and 5 cases were treated with X-ray fluoroscopy for the internal fixation of pedicle screws.Forty-one pedicle screws in simulated operation were implanted,which included 11 cases of level-Ⅰ,21 cases of level-Ⅱ and 5 cases of level-Ⅲ pedicle screws,and the success rate of which was 87.8%.Conclusions:The post-processing methods of CT three-dimensional reconstruction can accurately diagnose the atlantoaxial vertebral lesions,which combining with 3D printing technology in cervical pedicle screw placement operation is safe and short time,and can accurately evaluate the effect of pedicle screw insertion after surgery.
Objective:To investigate the application value of CT three-dimensional reconstruction combined with 3D printing technology in atlantoaxial pedicle screw placement operation.Methods:Thirteen atlantoaxial? lesions patients diagnosed by post-processing methods of CT three-dimensional reconstruction were set as the observation group.A kind of new navigation template guiding the atlantoaxial pedicle screw placement operation was designed through CT three-dimensional reconstruction,principle of reverse engineering and rapid prototyping technology.Thirteen patients treated with pedicle screw fixation by X-ray fluoroscopy were set as the control group.The treatment effect between two groups was compared.Results:Forty-one pedicle screws in control group were implanted,which included 9 cases of level-I,18 cases of level-Ⅱ and 14 cases of level-Ⅲ pedicle screws,and the success rate of which was 65.9%.Twenty-one guiding templates were designed in observation group,and 5 cases were treated with X-ray fluoroscopy for the internal fixation of pedicle screws.Forty-one pedicle screws in simulated operation were implanted,which included 11 cases of level-Ⅰ,21 cases of level-Ⅱ and 5 cases of level-Ⅲ pedicle screws,and the success rate of which was 87.8%.Conclusions:The post-processing methods of CT three-dimensional reconstruction can accurately diagnose the atlantoaxial vertebral lesions,which combining with 3D printing technology in cervical pedicle screw placement operation is safe and short time,and can accurately evaluate the effect of pedicle screw insertion after surgery.
2018, 43(6): 788-792.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.026
Abstract:
Objective:To evaluate the application value of 3.0 MRI 3D-FIESTA sequence combined with 3D-TOF-MRA imaging in the diagnosis of trigeminal nerve vascular compression.Methods:Sixty-three patients with trigeminal neuralgia were detected using 3.0 MRI 3D-FIESTA sequence combined with 3D-TOF-MRA scan,the responsibility blood vessel was analyzed using the relationship between trigeminal nerve and blood vessels,and which was compared with surgical results.Results:The positive diagnosis rates of vascular compression using MRI before operation and good standard diagnosis during operation in 63 cases were 82.5% and 87.30%,respectively,the difference of which was not statistically significant(χ2=0.558,P=0.558).In MRI imaging,the vascular compression in 40 cases,contact in 9 cases and suspected contact in 3 cases were found.Among the offending blood vessels,21 cases(40.38%) from superior cerebellar artery blood vessels,12 cases(23.07%) from anterior inferior cerebellar artery,6 cases(11.53%) from posterior inferior cerebellar artery,8 cases from vertebral-basilar artery and 5 cases(9.61%)from unknown artery around trigeminal nerve were identified.Among the offending blood vessels,23 cases(41.82%) from superior cerebellar artery,14 cases(25.46%) from anterior inferior cerebellar artery,5 cases(9.09%) from posterior inferior cerebellar artery,9 cases(16.36%) from vertebral-basilar artery and 4 case(7.27%) from unknown vascular compression were found during operation.Among 63 cases compared with the operation results,the preoperative MRI diagnosis in 15 cases(23.81%) was not in accord with intraoperative diagnosis.The diagnosis of preoperative free of oppression and intraoperative oppression showed 3 cases(4.76%) of superior cerebellar artery,1 case(1.59%) of posterior inferior cerebellar artery,2 cases(2.17%) of vertebral-basilar artery,4 cases(6.35%) of venous compression or arachnoid adhesion.The preoperative MRI diagnosis in 5 cases(7.94%) was not in accord with the offending blood vessel.Conclusions:The 3.0 MRI 3D-FIESTA sequence combined with 3D-TOF-MRA imaging technology can display the trigeminal nerve vascular compression,provide the accurate imaging basis in minimally invasive surgery.The diagnosis of offending blood vessel is still different because of the partial volume influence.
Objective:To evaluate the application value of 3.0 MRI 3D-FIESTA sequence combined with 3D-TOF-MRA imaging in the diagnosis of trigeminal nerve vascular compression.Methods:Sixty-three patients with trigeminal neuralgia were detected using 3.0 MRI 3D-FIESTA sequence combined with 3D-TOF-MRA scan,the responsibility blood vessel was analyzed using the relationship between trigeminal nerve and blood vessels,and which was compared with surgical results.Results:The positive diagnosis rates of vascular compression using MRI before operation and good standard diagnosis during operation in 63 cases were 82.5% and 87.30%,respectively,the difference of which was not statistically significant(χ2=0.558,P=0.558).In MRI imaging,the vascular compression in 40 cases,contact in 9 cases and suspected contact in 3 cases were found.Among the offending blood vessels,21 cases(40.38%) from superior cerebellar artery blood vessels,12 cases(23.07%) from anterior inferior cerebellar artery,6 cases(11.53%) from posterior inferior cerebellar artery,8 cases from vertebral-basilar artery and 5 cases(9.61%)from unknown artery around trigeminal nerve were identified.Among the offending blood vessels,23 cases(41.82%) from superior cerebellar artery,14 cases(25.46%) from anterior inferior cerebellar artery,5 cases(9.09%) from posterior inferior cerebellar artery,9 cases(16.36%) from vertebral-basilar artery and 4 case(7.27%) from unknown vascular compression were found during operation.Among 63 cases compared with the operation results,the preoperative MRI diagnosis in 15 cases(23.81%) was not in accord with intraoperative diagnosis.The diagnosis of preoperative free of oppression and intraoperative oppression showed 3 cases(4.76%) of superior cerebellar artery,1 case(1.59%) of posterior inferior cerebellar artery,2 cases(2.17%) of vertebral-basilar artery,4 cases(6.35%) of venous compression or arachnoid adhesion.The preoperative MRI diagnosis in 5 cases(7.94%) was not in accord with the offending blood vessel.Conclusions:The 3.0 MRI 3D-FIESTA sequence combined with 3D-TOF-MRA imaging technology can display the trigeminal nerve vascular compression,provide the accurate imaging basis in minimally invasive surgery.The diagnosis of offending blood vessel is still different because of the partial volume influence.
2018, 43(6): 793-796,820.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.027
Abstract:
Objective:To explore the predictive value of pregnancy-associated plasma protein A(PAPP-A),free estriol(fE3) and β-human choionic gonadotophin(β-hCG) on preeclampsia.Methods:A total of 117 pregnant women with pregnancy-induced hypertension were divided into the preeclampsia group(49 cases) and pregnancy induced hypertension group(68 cases),and 90 healthy pregnant women were set as the control group.The serum levels of PAPP-A,fE3 and β-hCG in three groups during 15 to 20 weeks and 24 to 28 weeks of pregnancy were detected by enzyme linked immunosorbent assay,and the serum levels of PAPP-A,fE3 and β-hCG between three groups were compared.The receiver operating curve(ROC) was drawn according to the serum levels of PAPP-A,fE3 and β-hCG,and the predictive value of PAPP-A,fE3 and β-hCG on preeclampsia was evaluated.Results:The differences of the age,parity and body mass index between three groups were not statistically significant(P>0.05),and the gestational weeks,neonatal birth weight and 1 minute Apgar scores in preeclampsia group were significantly lower than those in pregnancy induced hypertension group and control group(P<0.05).During the 15 to 20 weeks of pregnancy,the differences of the serum levels of PAPP-A,fE3 and β-hCG between three groups were not statistically significant(P>0.05).During the 24 to 28 weeks of pregnancy,the serum levels of PAPP-A and fE3 in preeclampsia group were lower than those in pregnancy induced hypertension group and control group,and the serum level of β-hCG in preeclampsia group was higher than that in pregnancy induced hypertension group and control group(P<0.05).During the 24 to 28 weeks of pregnancy,the correlation analysis showed that serum level of PAPP-A was positively correlated with gestational age and neonatal birth weight(P<0.05 and P<0.01),the serum level of fE3 was positively correlated with gestational age(P<0.01),and the serum level of β-hCG was negatively correlated with neonatal 1 minute Apgar score(P<0.01).The prediction value of the combination of serum PAPP-A,fE3 and β-hCG was better than that of single index(P<0.05).The serum levels of PAPP-A,fE3,β-hCG,and combination detection had predictive value on preeclampsia(P<0.05).The area under the ROC curve of three indexes combination was the highest(0.857).Conclusions:In middle pregnancy of preeclampsia pregnant women,the serum levels of PAPP-A and fE3 decrease,and the level of β-hCG increases.During the 24 to 28 weeks of pregnancy,the combination detection of serum PAPP-A,fE3 and β-hCG can provide a basis for predicting preeclampsia.
Objective:To explore the predictive value of pregnancy-associated plasma protein A(PAPP-A),free estriol(fE3) and β-human choionic gonadotophin(β-hCG) on preeclampsia.Methods:A total of 117 pregnant women with pregnancy-induced hypertension were divided into the preeclampsia group(49 cases) and pregnancy induced hypertension group(68 cases),and 90 healthy pregnant women were set as the control group.The serum levels of PAPP-A,fE3 and β-hCG in three groups during 15 to 20 weeks and 24 to 28 weeks of pregnancy were detected by enzyme linked immunosorbent assay,and the serum levels of PAPP-A,fE3 and β-hCG between three groups were compared.The receiver operating curve(ROC) was drawn according to the serum levels of PAPP-A,fE3 and β-hCG,and the predictive value of PAPP-A,fE3 and β-hCG on preeclampsia was evaluated.Results:The differences of the age,parity and body mass index between three groups were not statistically significant(P>0.05),and the gestational weeks,neonatal birth weight and 1 minute Apgar scores in preeclampsia group were significantly lower than those in pregnancy induced hypertension group and control group(P<0.05).During the 15 to 20 weeks of pregnancy,the differences of the serum levels of PAPP-A,fE3 and β-hCG between three groups were not statistically significant(P>0.05).During the 24 to 28 weeks of pregnancy,the serum levels of PAPP-A and fE3 in preeclampsia group were lower than those in pregnancy induced hypertension group and control group,and the serum level of β-hCG in preeclampsia group was higher than that in pregnancy induced hypertension group and control group(P<0.05).During the 24 to 28 weeks of pregnancy,the correlation analysis showed that serum level of PAPP-A was positively correlated with gestational age and neonatal birth weight(P<0.05 and P<0.01),the serum level of fE3 was positively correlated with gestational age(P<0.01),and the serum level of β-hCG was negatively correlated with neonatal 1 minute Apgar score(P<0.01).The prediction value of the combination of serum PAPP-A,fE3 and β-hCG was better than that of single index(P<0.05).The serum levels of PAPP-A,fE3,β-hCG,and combination detection had predictive value on preeclampsia(P<0.05).The area under the ROC curve of three indexes combination was the highest(0.857).Conclusions:In middle pregnancy of preeclampsia pregnant women,the serum levels of PAPP-A and fE3 decrease,and the level of β-hCG increases.During the 24 to 28 weeks of pregnancy,the combination detection of serum PAPP-A,fE3 and β-hCG can provide a basis for predicting preeclampsia.
2018, 43(6): 805-807.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.031
Abstract:
Objective:To study the application effects of the improved nurse-based and anesthesiologist and specialist-supervised acute pain management system(NBASS-APS) in postoperative patients with ankle fracture.Methods:A total of 64 patients with ankle fractures were randomly divided into the intervention group(n=32) and control group(n=32).The intervention group was nursed using NBASS-APS,and the control group was nursed using the routine acute pain service model.The postoperative analgesic effect,sleep time after 24 h and 48 h of operation,hospital stay and patients' satisfaction between two groups were compared.Results:The scores of VASmax,meanVAS,Tmax and PVAS in intervention group were lower than those in control group(P<0.05 to P<0.01),and the sleep time in intervention group after 24 h and 48 h of operation were longer than those in control group(P<0.05).The hospital stay in intervention group was significantly shorter than that in control group(P<0.01),and the patients' satisfaction on analgesic effect in intervention group was significantly better than that in control group(P<0.01).Conclusions:The application of NBASS-APS in patients with ankle fracture can effectively reduce pain,recover physiological function and improve patients' satisfaction,which is suitable for clinical use.
Objective:To study the application effects of the improved nurse-based and anesthesiologist and specialist-supervised acute pain management system(NBASS-APS) in postoperative patients with ankle fracture.Methods:A total of 64 patients with ankle fractures were randomly divided into the intervention group(n=32) and control group(n=32).The intervention group was nursed using NBASS-APS,and the control group was nursed using the routine acute pain service model.The postoperative analgesic effect,sleep time after 24 h and 48 h of operation,hospital stay and patients' satisfaction between two groups were compared.Results:The scores of VASmax,meanVAS,Tmax and PVAS in intervention group were lower than those in control group(P<0.05 to P<0.01),and the sleep time in intervention group after 24 h and 48 h of operation were longer than those in control group(P<0.05).The hospital stay in intervention group was significantly shorter than that in control group(P<0.01),and the patients' satisfaction on analgesic effect in intervention group was significantly better than that in control group(P<0.01).Conclusions:The application of NBASS-APS in patients with ankle fracture can effectively reduce pain,recover physiological function and improve patients' satisfaction,which is suitable for clinical use.
2018, 43(6): 808-811.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.032
Abstract:
Objective:To analyze the effects of plan,do,check and action(PDCA) nursing mode on decreasing the related infection and incidence rate of adverse event in elderly tumor patients treated with peripherally inserted central catheter(PICC).Methods:One hundred and eight elderly tumor patients treated with PICC were randomly divided into the control group and intervention group(54 cases each group).The control group and intervention group were nursed using routine nursing mode and PDCA nursing mode on the basis of the control group,respectively.The PICC-related infection and adverse events between two groups were compared.Results:The total incidence rate of the PICC-related infection and adverse events such as unplanned extubation,mechanical phlebitis,catheter ablation and catheter blockage in intervention group(11.11%) were significantly lower than that in control group (53.70%)(P<0.01).Compared with the control group,the time of catheter indwelling significantly prolonged,the one-time puncture success rate,catheter compliance and satisfaction increased in intervention group(P<0.05 to P<0.01).The scores of PICC operation skill,communication skill,nursing attitude,responsibility and handling ability to PICC accident in intervention group were significantly higher than those in control group(P<0.01).Conclusions:PDCA nursing mode can significantly reduce the incidence rate of PICC-related infection and adverse events,improve the quality of nursing,increase the catheter retention time,and improve the satisfaction in elderly cancer patients,which has good clinical application value.
Objective:To analyze the effects of plan,do,check and action(PDCA) nursing mode on decreasing the related infection and incidence rate of adverse event in elderly tumor patients treated with peripherally inserted central catheter(PICC).Methods:One hundred and eight elderly tumor patients treated with PICC were randomly divided into the control group and intervention group(54 cases each group).The control group and intervention group were nursed using routine nursing mode and PDCA nursing mode on the basis of the control group,respectively.The PICC-related infection and adverse events between two groups were compared.Results:The total incidence rate of the PICC-related infection and adverse events such as unplanned extubation,mechanical phlebitis,catheter ablation and catheter blockage in intervention group(11.11%) were significantly lower than that in control group (53.70%)(P<0.01).Compared with the control group,the time of catheter indwelling significantly prolonged,the one-time puncture success rate,catheter compliance and satisfaction increased in intervention group(P<0.05 to P<0.01).The scores of PICC operation skill,communication skill,nursing attitude,responsibility and handling ability to PICC accident in intervention group were significantly higher than those in control group(P<0.01).Conclusions:PDCA nursing mode can significantly reduce the incidence rate of PICC-related infection and adverse events,improve the quality of nursing,increase the catheter retention time,and improve the satisfaction in elderly cancer patients,which has good clinical application value.
2018, 43(6): 812-815.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.033
Abstract:
Objective:To investigate the application effects of the protective motivation theory on self-management behavior of patients with type 2 diabetes mellitus.Methods:One hundred and twenty patients with type 2 diabetes mellitus were divided into the control group(62 cases) and experiment group(58 cases each group).The control group was taught with conventional health theory,and the experiment group was taught with the health theory based on protective motivation theory.The blood glucose level and body mass index in two groups were analyzed after intervention.The self-management ability and quality of life in two groups were evaluated using the self-management behavior questionnaire and quality of life scale.Results:After 3 months of intervention,the levels of fasting blood glucose,postprandial 2h blood glucose,glycated hemoglobin and body mass index in experiment group were significantly lower than those in control group(P<0.01).The total score of self-management behavior scale and each dimension score in experiment group were significantly higher than those in control group(P<0.01),and the difference of the regular exercise score between two groups was not statistically significant(P>0.05).Conclusions:The health education based on the protective motivation theory is conducive to control the level of the blood glucose and body mass index,and improve the self-management ability and the quality of life of patients.
Objective:To investigate the application effects of the protective motivation theory on self-management behavior of patients with type 2 diabetes mellitus.Methods:One hundred and twenty patients with type 2 diabetes mellitus were divided into the control group(62 cases) and experiment group(58 cases each group).The control group was taught with conventional health theory,and the experiment group was taught with the health theory based on protective motivation theory.The blood glucose level and body mass index in two groups were analyzed after intervention.The self-management ability and quality of life in two groups were evaluated using the self-management behavior questionnaire and quality of life scale.Results:After 3 months of intervention,the levels of fasting blood glucose,postprandial 2h blood glucose,glycated hemoglobin and body mass index in experiment group were significantly lower than those in control group(P<0.01).The total score of self-management behavior scale and each dimension score in experiment group were significantly higher than those in control group(P<0.01),and the difference of the regular exercise score between two groups was not statistically significant(P>0.05).Conclusions:The health education based on the protective motivation theory is conducive to control the level of the blood glucose and body mass index,and improve the self-management ability and the quality of life of patients.
2018, 43(6): 816-820.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.034
Abstract:
Objective:To explore the effects of nursing mode based on King interaction standard theory on the quality of life and compliance of hemodialysis patients.Methods:Eighty-four hemodialysis patients were randomly divided into the study group and the control group according to the random number table(42 cases each group).The control group was nursed using traditional nursing method,and the study group was additionally nursed using the King interaction standard theory based on the control group.Two groups were assessed using the quality of life scale(SF-36) before and after 4 weeks of intervention,and the treatment compliance and nursing satisfaction between two groups were compared.Results:There was not statistical significance in the quality of life score between two groups before the intervention(P>0.05).After the intervention,the scores of physical function,role physical,body pain,general health,vitality,social expectation function,role emotional and mental health in study group were higher than those in control group(P<0.05 to P<0.01).Before intervention,the difference of the good rate of treatment compliance between two groups was not statistically significant(P>0.05),and which in study group was higher than that in control group after intervention(P<0.01).The nursing satisfaction rates in study group and control group were 97.6% and 80.9%,respectively,and the difference of which between two groups was statistically significant(P<0.01).Conclusions:The application of nursing mode based on King interaction standard theory in hemodialysis patients can help to improve the quality of life and treatment compliance of patients,which is worthy of promotion in clinic.
Objective:To explore the effects of nursing mode based on King interaction standard theory on the quality of life and compliance of hemodialysis patients.Methods:Eighty-four hemodialysis patients were randomly divided into the study group and the control group according to the random number table(42 cases each group).The control group was nursed using traditional nursing method,and the study group was additionally nursed using the King interaction standard theory based on the control group.Two groups were assessed using the quality of life scale(SF-36) before and after 4 weeks of intervention,and the treatment compliance and nursing satisfaction between two groups were compared.Results:There was not statistical significance in the quality of life score between two groups before the intervention(P>0.05).After the intervention,the scores of physical function,role physical,body pain,general health,vitality,social expectation function,role emotional and mental health in study group were higher than those in control group(P<0.05 to P<0.01).Before intervention,the difference of the good rate of treatment compliance between two groups was not statistically significant(P>0.05),and which in study group was higher than that in control group after intervention(P<0.01).The nursing satisfaction rates in study group and control group were 97.6% and 80.9%,respectively,and the difference of which between two groups was statistically significant(P<0.01).Conclusions:The application of nursing mode based on King interaction standard theory in hemodialysis patients can help to improve the quality of life and treatment compliance of patients,which is worthy of promotion in clinic.
2018, 43(6): 837-840.
doi: 10.13898/j.cnki.issn.1000-2200.2018.06.041
Abstract:
Objective:To explore the promotion effects of pharmacy skills competition on cultivating vocational ability.Methods:The effects of pharmacy skills competition on professional ability and comprehensive ability of pharmaceutical college students were analyzed using questionnaire.The comprehensive performance of two semesters in junior were tracked,and the correlation of which with skill competition result was analyzed.Results:The pharmacy skills competition improved the comprehensive ability of students by emphasizing the application and practice of main course knowledge,and the ranking of skills competition was positively correlated with the ranking of two semesters in junior year(P<0.01).The abilities of expression,attention,observation and teamwork of students were improved greatly through attending the skill competition.The innovative consciousness and innovation ability were cultivated by encouraging students to think independently in practice during skills competition.Conclusions:The skills competition plays active roles in the cultivation and formation of various professional abilities of students.
Objective:To explore the promotion effects of pharmacy skills competition on cultivating vocational ability.Methods:The effects of pharmacy skills competition on professional ability and comprehensive ability of pharmaceutical college students were analyzed using questionnaire.The comprehensive performance of two semesters in junior were tracked,and the correlation of which with skill competition result was analyzed.Results:The pharmacy skills competition improved the comprehensive ability of students by emphasizing the application and practice of main course knowledge,and the ranking of skills competition was positively correlated with the ranking of two semesters in junior year(P<0.01).The abilities of expression,attention,observation and teamwork of students were improved greatly through attending the skill competition.The innovative consciousness and innovation ability were cultivated by encouraging students to think independently in practice during skills competition.Conclusions:The skills competition plays active roles in the cultivation and formation of various professional abilities of students.
Email
RSS