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2018 Vol. 43, No. 7
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2018, 43(7): 841-844.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.001
Abstract:
Objective: To explore the expression of tumor necrosis factor-α (TNF-α),interleukin-1β(IL-1β) in human nucleus pulposus tissue of cervical intervertebral disc,and the relationship of cervical spondylotic myelopathy (CSM).Methods: Nucleus pulposus tissues of cervical intervertebral discs were obtained from 25 cases of patients treated with anterior cervical decompression,17 cases of CSM (CSM group) and 8 cases of cervical spine fracture or fracture-dislocation patients (NC group).Morphological changes of nucleus pulposus tissue were observed,the levels of TNF-α,IL-1β,TNF-α mRNA and IL-1β mRNA in nucleus pulposus tissue were measured.Results: There was statistically significant difference in age between the 2 groups(P < 0.05),but no statistically significant difference in gender and cervical position(P > 0.05).Compared with NC group,collagen fibers in nucleus pulposus tissue of cervical disc were disordered,the levels of TNF-α and IL-1β in nucleus pulposus tissue of cervical disc were increased significantly(P < 0.01),and the expressions of TNF-α mRNA and IL-1β mRNA were increased significantly in CSM group(P < 0.01).Conclusions: The levels of TNF-α and IL-1β were increasedsignificantly cervical intervertebral disk of patients with cervical spondylotic myelopathy,which may be associated with the occurrence and development of CSM.
Objective: To explore the expression of tumor necrosis factor-α (TNF-α),interleukin-1β(IL-1β) in human nucleus pulposus tissue of cervical intervertebral disc,and the relationship of cervical spondylotic myelopathy (CSM).Methods: Nucleus pulposus tissues of cervical intervertebral discs were obtained from 25 cases of patients treated with anterior cervical decompression,17 cases of CSM (CSM group) and 8 cases of cervical spine fracture or fracture-dislocation patients (NC group).Morphological changes of nucleus pulposus tissue were observed,the levels of TNF-α,IL-1β,TNF-α mRNA and IL-1β mRNA in nucleus pulposus tissue were measured.Results: There was statistically significant difference in age between the 2 groups(P < 0.05),but no statistically significant difference in gender and cervical position(P > 0.05).Compared with NC group,collagen fibers in nucleus pulposus tissue of cervical disc were disordered,the levels of TNF-α and IL-1β in nucleus pulposus tissue of cervical disc were increased significantly(P < 0.01),and the expressions of TNF-α mRNA and IL-1β mRNA were increased significantly in CSM group(P < 0.01).Conclusions: The levels of TNF-α and IL-1β were increasedsignificantly cervical intervertebral disk of patients with cervical spondylotic myelopathy,which may be associated with the occurrence and development of CSM.
2018, 43(7): 845-849.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.002
Abstract:
Objective: To investigate the expression and significance of ubiquitin-specific protease 7(USP7) in mice with pulmonary inflammation and fibrosis induced by bleomycin.Methods: Thirty six mice were randomly divided into the blank group and bleomycin group.The mice of bleomycin group were induced by bleomycin injection in trachea to establish the mouse pulmonary fibrosis model,and the blank group were injected with the same volume saline.After 7,14 and 21 days of molding,the mice were sacrificed.The lung coefficient and hydroxyproline contents were measured.The pathological change of lung tissue was observed using the HE staining and Masson's staining.The dynamic change of USP7 level in inflammation and fibrosis pulmonary tissue induced by bleomycin were detected using the immunohistochemical staining,and the correlation of which with lung collagen content was analyzed.Results: The lung coefficient value at each time-point in bleomycin group was significantly higher than that in blank group(P<0.01).The difference of the hydroxyproline content among each time-point in bleomycin group was statistically signficant(P<0.01),and the hydroxyproline content in bleomycin group at day 14 and 21 were significantly higher than that in blank group(P<0.01).The results of HE and staining and Masson showed that the bleomycin injection in trachea could induce the pulmonary inflammation and fibrosis in mice.The immunohistochemical staining showed the expression level of USP7 was low in normal lung tissue.The difference of the expression level of USP7 in bleomycin group among different time-points was statistically significant(P<0.01),which significantly increased compared with the blank group(P<0.05 to P<0.01),and gradually decreased with the time prolonging(P<0.01).Conclusions: The level change of USP7 in mice with pulmonary inflammation and fibrosis induced by bleomycin is dynamical,and which may play certain role in the occurrence and development of pulmonary fibrosis.
Objective: To investigate the expression and significance of ubiquitin-specific protease 7(USP7) in mice with pulmonary inflammation and fibrosis induced by bleomycin.Methods: Thirty six mice were randomly divided into the blank group and bleomycin group.The mice of bleomycin group were induced by bleomycin injection in trachea to establish the mouse pulmonary fibrosis model,and the blank group were injected with the same volume saline.After 7,14 and 21 days of molding,the mice were sacrificed.The lung coefficient and hydroxyproline contents were measured.The pathological change of lung tissue was observed using the HE staining and Masson's staining.The dynamic change of USP7 level in inflammation and fibrosis pulmonary tissue induced by bleomycin were detected using the immunohistochemical staining,and the correlation of which with lung collagen content was analyzed.Results: The lung coefficient value at each time-point in bleomycin group was significantly higher than that in blank group(P<0.01).The difference of the hydroxyproline content among each time-point in bleomycin group was statistically signficant(P<0.01),and the hydroxyproline content in bleomycin group at day 14 and 21 were significantly higher than that in blank group(P<0.01).The results of HE and staining and Masson showed that the bleomycin injection in trachea could induce the pulmonary inflammation and fibrosis in mice.The immunohistochemical staining showed the expression level of USP7 was low in normal lung tissue.The difference of the expression level of USP7 in bleomycin group among different time-points was statistically significant(P<0.01),which significantly increased compared with the blank group(P<0.05 to P<0.01),and gradually decreased with the time prolonging(P<0.01).Conclusions: The level change of USP7 in mice with pulmonary inflammation and fibrosis induced by bleomycin is dynamical,and which may play certain role in the occurrence and development of pulmonary fibrosis.
2018, 43(7): 850-853.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.003
Abstract:
Objective: To screen the marine microbial antithrombotic strains from Naozhou island in South China Sea,and study its effects on blood coagulation characteristics.Methods: The antithrombotic strains were screened by in vitro thrombolysis,and the effects of the screened strains on collagen-adrenergic-induced tail vein thrombosis,bleeding time and clotting time of mice,and thrombin-induced platelet aggregation of pig were investigated.Results: The in vitro thrombolysis experiments showed that the Staphylococcus saprophyticus(Mb19) and Acetobacter pylori(Lmb14) had obvious thrombolytic effect.The high-dose of supernatants(1 mL) of Mb19 and Lmb14 could effectively inhibit the formation of collagen-adrenergic-induced thrombosis in mouse,and the difference between which and 0.9% sodium chloride injection was statistically significant(P<0.05).The high-dose of supernatants(1 mL) of Mb19 and Lmb14 could effectively prolong the bleeding and clotting time of mice,and the difference between which and 0.9% sodium chloride injection was statistically significant(P<0.01).The high-dose of supernatants(1 mL) could inhibit the platelet aggregation.Conclusions: Mb19 and Lmb14 marine bacteria have the activity of anti-thrombosis.
Objective: To screen the marine microbial antithrombotic strains from Naozhou island in South China Sea,and study its effects on blood coagulation characteristics.Methods: The antithrombotic strains were screened by in vitro thrombolysis,and the effects of the screened strains on collagen-adrenergic-induced tail vein thrombosis,bleeding time and clotting time of mice,and thrombin-induced platelet aggregation of pig were investigated.Results: The in vitro thrombolysis experiments showed that the Staphylococcus saprophyticus(Mb19) and Acetobacter pylori(Lmb14) had obvious thrombolytic effect.The high-dose of supernatants(1 mL) of Mb19 and Lmb14 could effectively inhibit the formation of collagen-adrenergic-induced thrombosis in mouse,and the difference between which and 0.9% sodium chloride injection was statistically significant(P<0.05).The high-dose of supernatants(1 mL) of Mb19 and Lmb14 could effectively prolong the bleeding and clotting time of mice,and the difference between which and 0.9% sodium chloride injection was statistically significant(P<0.01).The high-dose of supernatants(1 mL) could inhibit the platelet aggregation.Conclusions: Mb19 and Lmb14 marine bacteria have the activity of anti-thrombosis.
2018, 43(7): 854-857.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.004
Abstract:
Objective: To compare the effects among the endoscopic full-thickness resection(EFR),laparotomy and laparoscopic surgery in treating gastric muscularis propria tumors.Methods: Among patients with gastric muscularis propria tumors,31 cases(EFR group),12 cases(laparotomy group) and 10 cases(laparoscopic group) were treated with EFR,laparotomy and laparoscopic surgery,respectively.The operation time,postoperative hospital stay,general expense,complications,relapse rate and metastatic rate among three groups were compared.Results: There were significant differences in operation time,postoperative hospital stay and general expense among three groups(P<0.05 to P<0.01).The results of pair-wise comparison showed that the postoperative hospital stay in EFR group was shorter than that in laparotomy group(P<0.05),the general expense in EFR group was less than that in other two groups(P<0.05 and P<0.01),and the general expense in laparotomy group was significantly less than that in laparoscopic group(P<0.01).The differences of the complicatiens were not statistically significant(P>0.05).The differences of risk factors grading were statistically significent(P<0.05).Conclusions: EFR in treating gastric muscularis propria tumors is small trauma,rapid recovery,low expense,safe and less recurrence,which is worthy of clinical promotion.
Objective: To compare the effects among the endoscopic full-thickness resection(EFR),laparotomy and laparoscopic surgery in treating gastric muscularis propria tumors.Methods: Among patients with gastric muscularis propria tumors,31 cases(EFR group),12 cases(laparotomy group) and 10 cases(laparoscopic group) were treated with EFR,laparotomy and laparoscopic surgery,respectively.The operation time,postoperative hospital stay,general expense,complications,relapse rate and metastatic rate among three groups were compared.Results: There were significant differences in operation time,postoperative hospital stay and general expense among three groups(P<0.05 to P<0.01).The results of pair-wise comparison showed that the postoperative hospital stay in EFR group was shorter than that in laparotomy group(P<0.05),the general expense in EFR group was less than that in other two groups(P<0.05 and P<0.01),and the general expense in laparotomy group was significantly less than that in laparoscopic group(P<0.01).The differences of the complicatiens were not statistically significant(P>0.05).The differences of risk factors grading were statistically significent(P<0.05).Conclusions: EFR in treating gastric muscularis propria tumors is small trauma,rapid recovery,low expense,safe and less recurrence,which is worthy of clinical promotion.
2018, 43(7): 858-861.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.005
Abstract:
Objective: To investigate the effects of different protein intake on the nutritional status and bone mineral metabolism in maintenance hemodialysis(MHD) patients.Methods: Eighty-four MHD patients were divided into the high intake group(n=42) and low intake group(n=42) according to different protein intakes.The protein intakes in the high intake group and low intake group were(1.32±0.15) g·kg-1·d-1 and(1.02±0.08) g·kg-1·d-1,respectively.The nutritional status and bone mineral metabolism in two groups were observed.Results: There was no statistical significance in body mass,body mass index,waist-hip ratio,upper arm muscle circumference,serum albumin,prealbumin and hemoglobin between two groups(P>0.05).The creatinine,urea nitrogen,total cholesterol,and normalized nitrogen performance equivalent protein in high intake group were higher than those in low intake group(P<0.05 to P<0.01).The levels of serum potassium,calcium,phosphorus and iPTH in high intake group were significantly higher than those in low intake group(P<0.01),and the level of carbon dioxide combining power in high intake group was significantly lower than that in low intake group(P<0.01).There was no statistical significance in the number of patients with residual renal function,urine volume and glomerular filtration rate between two groups(P>0.05),but the loss time in low intake group with residual renal function was significantly longer than that in high intake group(P<0.01).Conclusions: Controlling daily protein intake at about 1.02 g/kg in MHD patients can help to patients maintain a good nutritional status,and residual renal function for a long time.
Objective: To investigate the effects of different protein intake on the nutritional status and bone mineral metabolism in maintenance hemodialysis(MHD) patients.Methods: Eighty-four MHD patients were divided into the high intake group(n=42) and low intake group(n=42) according to different protein intakes.The protein intakes in the high intake group and low intake group were(1.32±0.15) g·kg-1·d-1 and(1.02±0.08) g·kg-1·d-1,respectively.The nutritional status and bone mineral metabolism in two groups were observed.Results: There was no statistical significance in body mass,body mass index,waist-hip ratio,upper arm muscle circumference,serum albumin,prealbumin and hemoglobin between two groups(P>0.05).The creatinine,urea nitrogen,total cholesterol,and normalized nitrogen performance equivalent protein in high intake group were higher than those in low intake group(P<0.05 to P<0.01).The levels of serum potassium,calcium,phosphorus and iPTH in high intake group were significantly higher than those in low intake group(P<0.01),and the level of carbon dioxide combining power in high intake group was significantly lower than that in low intake group(P<0.01).There was no statistical significance in the number of patients with residual renal function,urine volume and glomerular filtration rate between two groups(P>0.05),but the loss time in low intake group with residual renal function was significantly longer than that in high intake group(P<0.01).Conclusions: Controlling daily protein intake at about 1.02 g/kg in MHD patients can help to patients maintain a good nutritional status,and residual renal function for a long time.
2018, 43(7): 861-863,867.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.006
Abstract:
Objective: To investigate the effect of sarpogrelated on serum bilirubin and inflammatory factor level diabetic foot(DF).Methods: Eighty cases of DF patients were randomly divided into observation group and control group,each group of 40 cases.The control group was treated with basic treatment,while the treatment group was treated with sarpogrelated.After 6 months,the serum bilirubin and inflammatory factors were observed and recorded.Results: With the treatment,VCAM-1 and FGF2 of all patients were significantly decreased,and at 6 months after treatment,the VCAM-1 and FGF2 levels in observation group was lower than those in the control group(P < 0.01 and P < 0.05),with the treatment,TNF-α and IL-6 levels of all patients with were decreased,but at 6 months after treatment,TNF-α and IL-6 level in the observation group was lower than those in the control group(P < 0.05 and P < 0.01),with the treatment,TBIL,IBIL level of 2 groups has been restored,but at 6 months after treatment,the TBIL,IBIL level of observation group was significantly higher that of the control group(P < 0.05),the total efficiency of observation group was significantly higher than that of the control group,with significant difference between the two groups(P < 0.05).Conclusions: Sarpogrelated can effectively improve the serum inflammatory factors,improve the level of bilirubin and improve the therapeutic effect.
Objective: To investigate the effect of sarpogrelated on serum bilirubin and inflammatory factor level diabetic foot(DF).Methods: Eighty cases of DF patients were randomly divided into observation group and control group,each group of 40 cases.The control group was treated with basic treatment,while the treatment group was treated with sarpogrelated.After 6 months,the serum bilirubin and inflammatory factors were observed and recorded.Results: With the treatment,VCAM-1 and FGF2 of all patients were significantly decreased,and at 6 months after treatment,the VCAM-1 and FGF2 levels in observation group was lower than those in the control group(P < 0.01 and P < 0.05),with the treatment,TNF-α and IL-6 levels of all patients with were decreased,but at 6 months after treatment,TNF-α and IL-6 level in the observation group was lower than those in the control group(P < 0.05 and P < 0.01),with the treatment,TBIL,IBIL level of 2 groups has been restored,but at 6 months after treatment,the TBIL,IBIL level of observation group was significantly higher that of the control group(P < 0.05),the total efficiency of observation group was significantly higher than that of the control group,with significant difference between the two groups(P < 0.05).Conclusions: Sarpogrelated can effectively improve the serum inflammatory factors,improve the level of bilirubin and improve the therapeutic effect.
2018, 43(7): 864-867.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.007
Abstract:
Objective: To observe the effects of the preserving quadratus femoris on the bone mass of femoral calcar in atificial hip arthroplasty.Methods: Sixty femoral neck fracture patients treated with artificial hip arthroplasty were randomly divided into the observation group and control group(30 cases each group).The control group was treated with cutting off quadratus femoris,and the observation group was treated with preserving quadratus femoris.The operation time,blood loss and Harris hip score in two groups after 12 months of operation were observed.The bone mass of femoral calcar in two groups were investigated using craniocaudal oblique of 45-degree X-ray film after 3,6,12 and 24 months of operation.Results: The differences of the operation time,blood loss and Harris hip score after 12 months of operation between two groups were not statistically significant(P>0.05).The differences of the bone mass of the femoral calcar after 3,6 and 12 months of operation between two groups were not statistically significant(P>0.05),and the loss bone mass of femoral calcar after 24 months of operation in control group was higher than that in observation group(P<0.05).Conclusions: The preserving quadratus femoris in artificial hip arthroplasty may reduce the bone absorption of femoral calcar,and effectively decrease the osteolysis of femoral calcar.
Objective: To observe the effects of the preserving quadratus femoris on the bone mass of femoral calcar in atificial hip arthroplasty.Methods: Sixty femoral neck fracture patients treated with artificial hip arthroplasty were randomly divided into the observation group and control group(30 cases each group).The control group was treated with cutting off quadratus femoris,and the observation group was treated with preserving quadratus femoris.The operation time,blood loss and Harris hip score in two groups after 12 months of operation were observed.The bone mass of femoral calcar in two groups were investigated using craniocaudal oblique of 45-degree X-ray film after 3,6,12 and 24 months of operation.Results: The differences of the operation time,blood loss and Harris hip score after 12 months of operation between two groups were not statistically significant(P>0.05).The differences of the bone mass of the femoral calcar after 3,6 and 12 months of operation between two groups were not statistically significant(P>0.05),and the loss bone mass of femoral calcar after 24 months of operation in control group was higher than that in observation group(P<0.05).Conclusions: The preserving quadratus femoris in artificial hip arthroplasty may reduce the bone absorption of femoral calcar,and effectively decrease the osteolysis of femoral calcar.
2018, 43(7): 868-873.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.008
Abstract:
Objective: To compare the effects between single hole and multi-hole laparoscopy in the radical operation of sigmoid colon and rectal cancer,and assess the feasibility of single hole laparoscopy.Methods: One hundred and twenty colorectal cancer patients during January 2014 to January 2016 were randomly divided into the single hole group and mutli-hole group using the random number table method(60 cases each group).The single hole group and mutli-hole group were treated with single hole and mutli-hole laparoscopic colorectal cancer radical operation,respectively.The intraoperative situation,postoperative recovery,complication and quality of life between two groups were compared.Results: The differences of operation time,amount of bleeding,tumor volume,distance from distal incision margin to the low margin of tumor,and number of lymph node dissection and positive lymph nodes between two groups were not statistically significant(P>0.05).The length of incision in single hole group was significantly shorter than that in multi-hole group(P<0.01).The distance from the proximal cut edge to the upper margin of tumor in single hole group was significantly longer than that in multi-hole group(P<0.01).The anus automatical exhausts time,eating liquid food time,eating solid food time and first defecating time in single hole group were significantly shorter than those in multi-hole group(P<0.01).The levels of motilin in two groups after operation decreased compared before operation(P<0.05 and P<0.01),and which in single hole group was significantly higher than that in multi-hole group(P<0.01).The postoperative VAS score,beauty index and length of stay in single hole group were significantly smaller,higher and shorter than those in multi-hole group,respectively(P<0.01).The incidence rate of early complications(including incisional infection,incision disruption,pulmonary infection,urinary tract infection and anastomotic fistula or bleeding)(3.33%) in single hole group was less than that in multi-hole group(13.33%)(P<0.05).The difference of the incidence rate of the long-term complications(including recurrence,distant metastasis and death) between two groups was not statistically significant(P>0.05).The GIQLI scores in single hole group at discharge and during the following up in single hole group were higher than that in multi-hole group(P<0.05 to P<0.01).The difference of the GIQLI scores in two groups between before and after operation were statistically significant(P<0.01),and the GIQLI scores in two groups at discharge and during the following up were significantly higher than that before operation(P<0.01).Conclusions: The single hole laparoscopy in the radical operation of sigmoid colon and rectal cancer is good effect,quick recovery,good cosmetic result,and good prognosis,which can significantly improve the quality of life of patients,and be used as one of the preferred surgical plan.
Objective: To compare the effects between single hole and multi-hole laparoscopy in the radical operation of sigmoid colon and rectal cancer,and assess the feasibility of single hole laparoscopy.Methods: One hundred and twenty colorectal cancer patients during January 2014 to January 2016 were randomly divided into the single hole group and mutli-hole group using the random number table method(60 cases each group).The single hole group and mutli-hole group were treated with single hole and mutli-hole laparoscopic colorectal cancer radical operation,respectively.The intraoperative situation,postoperative recovery,complication and quality of life between two groups were compared.Results: The differences of operation time,amount of bleeding,tumor volume,distance from distal incision margin to the low margin of tumor,and number of lymph node dissection and positive lymph nodes between two groups were not statistically significant(P>0.05).The length of incision in single hole group was significantly shorter than that in multi-hole group(P<0.01).The distance from the proximal cut edge to the upper margin of tumor in single hole group was significantly longer than that in multi-hole group(P<0.01).The anus automatical exhausts time,eating liquid food time,eating solid food time and first defecating time in single hole group were significantly shorter than those in multi-hole group(P<0.01).The levels of motilin in two groups after operation decreased compared before operation(P<0.05 and P<0.01),and which in single hole group was significantly higher than that in multi-hole group(P<0.01).The postoperative VAS score,beauty index and length of stay in single hole group were significantly smaller,higher and shorter than those in multi-hole group,respectively(P<0.01).The incidence rate of early complications(including incisional infection,incision disruption,pulmonary infection,urinary tract infection and anastomotic fistula or bleeding)(3.33%) in single hole group was less than that in multi-hole group(13.33%)(P<0.05).The difference of the incidence rate of the long-term complications(including recurrence,distant metastasis and death) between two groups was not statistically significant(P>0.05).The GIQLI scores in single hole group at discharge and during the following up in single hole group were higher than that in multi-hole group(P<0.05 to P<0.01).The difference of the GIQLI scores in two groups between before and after operation were statistically significant(P<0.01),and the GIQLI scores in two groups at discharge and during the following up were significantly higher than that before operation(P<0.01).Conclusions: The single hole laparoscopy in the radical operation of sigmoid colon and rectal cancer is good effect,quick recovery,good cosmetic result,and good prognosis,which can significantly improve the quality of life of patients,and be used as one of the preferred surgical plan.
2018, 43(7): 874-876,881.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.009
Abstract:
Objective: To explore the effects of different surgical approaches in the treatment of breast fibroma on the prognosis and nipple-areola cutaneous sensibility.Methods: One hundred and four women with breast fibroma were randomly divided into the observation group and control group(52 cases each grop).The control group were treated with arc incision arround areola margin,and the observation group were treated with trans-areola incision.The operation time,perioperative bleeding,incision size,hospital stay,incision healing time,postoperative complications,recurrence rate,and sensory recovery time of the nipple and areola skin between two groups were compared.Results: The intraoperative bleeding and operation time in observation group were significantly less than those in control group(P<0.01).There was no statistical significance in the length of incision between two groups(P>0.05).The time of hospitalization and incision healing in observation group were significantly shorter than those in control group(P<0.01),the incidence rate of postoperative complication and recurrence rate in observation group were significantly lower than those in control group(P<0.01 and P<0.05),and the satisfaction with scar in observation group was significantly higher than that in control group(P<0.01).The difference of the sensory recovery time of nipple and areola skin between two groups was not statistically significant(P>0.05).Conclusions: The trans-areola incision in the treatment of breast fibroma is good effect and prognosis,the nipple-areola cutaneous sensibility is well restored after operation.
Objective: To explore the effects of different surgical approaches in the treatment of breast fibroma on the prognosis and nipple-areola cutaneous sensibility.Methods: One hundred and four women with breast fibroma were randomly divided into the observation group and control group(52 cases each grop).The control group were treated with arc incision arround areola margin,and the observation group were treated with trans-areola incision.The operation time,perioperative bleeding,incision size,hospital stay,incision healing time,postoperative complications,recurrence rate,and sensory recovery time of the nipple and areola skin between two groups were compared.Results: The intraoperative bleeding and operation time in observation group were significantly less than those in control group(P<0.01).There was no statistical significance in the length of incision between two groups(P>0.05).The time of hospitalization and incision healing in observation group were significantly shorter than those in control group(P<0.01),the incidence rate of postoperative complication and recurrence rate in observation group were significantly lower than those in control group(P<0.01 and P<0.05),and the satisfaction with scar in observation group was significantly higher than that in control group(P<0.01).The difference of the sensory recovery time of nipple and areola skin between two groups was not statistically significant(P>0.05).Conclusions: The trans-areola incision in the treatment of breast fibroma is good effect and prognosis,the nipple-areola cutaneous sensibility is well restored after operation.
2018, 43(7): 877-881.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.010
Abstract:
Objective: To explore the effects of hyperbaric oxygen(HBO) on immune function and prognosis in the early comprehensive treatment of patients with craniocerebral injury.Methods: One hundred and eighteen patients with craniocerebral injury were randomly divided into the control group(59 cases) and observation group(59 cases).The control group were treated with HBO after 31 to 60d of craniocerebral injury,and the observation group were treated with HBO after 8 to 30d of craniocerebral injury.The scores of GCS and ADL,level of inflammatory cytokine,immune indicator,GOS staging and complications between two groups were compared.Results: After three courses of treatment,the scores of GCS and ADL in observation groups were significantly higher than those in control group(P<0.01).After two weeks of treatment,the levels of IL-2,IL-6,IL-8 and TNF-α in observation group were significantly lower than those in control group(P<0.01),and the levels of IgG,IgA,IgM and TLC in observation group were significantly higher than those in control group(P<0.01).The GOS staging in observation group was significantly better than that in control group(P<0.01).The incidence rate of complication in observation group was significantly lower than that in control group(P<0.01).Conclusions: The effect of HBO in the early comprehensive treatment of patients with craniocerebral injury is significant,which can significantly reduce the level of inflammatory cytokine and incidence of complication,improve the patients' immune function,and is safe and worthy of promotion in clinic.
Objective: To explore the effects of hyperbaric oxygen(HBO) on immune function and prognosis in the early comprehensive treatment of patients with craniocerebral injury.Methods: One hundred and eighteen patients with craniocerebral injury were randomly divided into the control group(59 cases) and observation group(59 cases).The control group were treated with HBO after 31 to 60d of craniocerebral injury,and the observation group were treated with HBO after 8 to 30d of craniocerebral injury.The scores of GCS and ADL,level of inflammatory cytokine,immune indicator,GOS staging and complications between two groups were compared.Results: After three courses of treatment,the scores of GCS and ADL in observation groups were significantly higher than those in control group(P<0.01).After two weeks of treatment,the levels of IL-2,IL-6,IL-8 and TNF-α in observation group were significantly lower than those in control group(P<0.01),and the levels of IgG,IgA,IgM and TLC in observation group were significantly higher than those in control group(P<0.01).The GOS staging in observation group was significantly better than that in control group(P<0.01).The incidence rate of complication in observation group was significantly lower than that in control group(P<0.01).Conclusions: The effect of HBO in the early comprehensive treatment of patients with craniocerebral injury is significant,which can significantly reduce the level of inflammatory cytokine and incidence of complication,improve the patients' immune function,and is safe and worthy of promotion in clinic.
2018, 43(7): 882-885.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.011
Abstract:
Objective: To investigate the effects of different risk factors on perioperative pulmonary infection in elderly hip fracture patients.Methods: The clinical data of 120 elderly patients with hip fracture,which included 60 cases complicated with pulmonary infection and 60 cases complicated without pulmonary infection,were retrospectively analyzed.The clinical indexes between two groups were compared.The risk factors of hip fracture complicated with perioperative pulmonary infection in elderly patients were analyzed using logistic regression analysis.Results: The results of univariate analysis showed that the smoking,chronic obstructive pulmonary disease,history of diabetes,heart disease,mechanical ventilation,transfusing red bloodcell,preoperative low body mass index,preoperative low albumin,ICU admission,operation time and hospital stay were the risk factors of perioperative pulmonary infection in elderly patients with hip fracture(P<0.05 to P<0.01).The results of multivariate regression analysis showed that the age more than 80 years,chronic obstructive pulmonary disease,history of diabetes,mechanical ventilation and operation time ≥ 2 h were the independent risk factors of perioperative pulmonary infection in elderly patients with hip fracture(P<0.05).Conclusions: The age more than 80 years,chronic obstructive pulmonary disease,history of diabetes,mechanical ventilation and operation time ≥ 2 h can increase the risk of perioperative pulmonary infection in elderly patients with hip fracture.
Objective: To investigate the effects of different risk factors on perioperative pulmonary infection in elderly hip fracture patients.Methods: The clinical data of 120 elderly patients with hip fracture,which included 60 cases complicated with pulmonary infection and 60 cases complicated without pulmonary infection,were retrospectively analyzed.The clinical indexes between two groups were compared.The risk factors of hip fracture complicated with perioperative pulmonary infection in elderly patients were analyzed using logistic regression analysis.Results: The results of univariate analysis showed that the smoking,chronic obstructive pulmonary disease,history of diabetes,heart disease,mechanical ventilation,transfusing red bloodcell,preoperative low body mass index,preoperative low albumin,ICU admission,operation time and hospital stay were the risk factors of perioperative pulmonary infection in elderly patients with hip fracture(P<0.05 to P<0.01).The results of multivariate regression analysis showed that the age more than 80 years,chronic obstructive pulmonary disease,history of diabetes,mechanical ventilation and operation time ≥ 2 h were the independent risk factors of perioperative pulmonary infection in elderly patients with hip fracture(P<0.05).Conclusions: The age more than 80 years,chronic obstructive pulmonary disease,history of diabetes,mechanical ventilation and operation time ≥ 2 h can increase the risk of perioperative pulmonary infection in elderly patients with hip fracture.
2018, 43(7): 885-886,891.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.012
Abstract:
Objective: To investigate the effects of enteral nutrition on preventing gastroparesis syndrome after pancreatoduodenectomy.Methods: Among 1 847 patients treated with pancreatoduodenectomy,917 cases were treated with total parenteral nutrition,and 930 cases were treated with parenteral nutrition combined with enteral nutrition.The incidence rate of postoperative gastroparesis syndrome and recovery time between two groups were compared.Results: The incidence rates of gastroparesis in total parenteral nutrition group(4.4%) were significantly higher than that in parenteral nutrition combined with enteral nutrition group(1.6%)(P<0.01).The recovery time of gastroparesis in total parenteral nutrition group[(24.2±4.5)d] were significantly longer than that in parenteral nutrition combined with enteral nutrition group[(9.6±3.3)d](P<0.01).Conclusions: The postoperative gastrointestinal function recovery of parenteral nutrition combined with enteral nutrition in the treatment of gastroparesis is better than that of parenteral nutrition.
Objective: To investigate the effects of enteral nutrition on preventing gastroparesis syndrome after pancreatoduodenectomy.Methods: Among 1 847 patients treated with pancreatoduodenectomy,917 cases were treated with total parenteral nutrition,and 930 cases were treated with parenteral nutrition combined with enteral nutrition.The incidence rate of postoperative gastroparesis syndrome and recovery time between two groups were compared.Results: The incidence rates of gastroparesis in total parenteral nutrition group(4.4%) were significantly higher than that in parenteral nutrition combined with enteral nutrition group(1.6%)(P<0.01).The recovery time of gastroparesis in total parenteral nutrition group[(24.2±4.5)d] were significantly longer than that in parenteral nutrition combined with enteral nutrition group[(9.6±3.3)d](P<0.01).Conclusions: The postoperative gastrointestinal function recovery of parenteral nutrition combined with enteral nutrition in the treatment of gastroparesis is better than that of parenteral nutrition.
2018, 43(7): 887-891.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.013
Abstract:
Objective: To analyze the clinical and etiologic features of neonatal septicemia.Methods: The clinical data of 124 neonatal septicemia cases from March 2013 to February 2017 were retrospectively analyzed.The patients were divided into the early onset group and late onset group according to the onset time,and the difference between two groups was compared.Results: The ratio of neonatal septicemia cases to the hospitalized newborns at the same time was 3.4%(124/3634),54.8% of which was the early onset type,and the major performances of which were jaundice,groans,cyanosis,dyspnea,responsiveness decreasing and C-reactive protein increasing.The 45.2% of patients were the late onset type,and the major performances of which were fever,dyspnea,jaundice,and focal infection.The incidence rates of the premature rupture of fetal membrane and amniotic fluid pollution in early onset group were higher than those in late onset group(P<0.05),the incidence rates of jaundice,groan,cyanosis,dyspnea and poor response in early onset group were significantly higher than those in late onset group(P<0.01).The incidence rate of the pneumonia complicated with focal infection in early onset group was lower than that in late onset group(P<0.01 and P<0.05).Among the septicaemic pathogens,88.7% of which was gram-positive bacteria,and 11.3% of which was gram-negative bacteria.The gram-positive bacteria was highly sensitive to vancomycin,minocycline and fusidic acid,and the gram-negative bacteria was highly sensitive to carbapenems.Conclusions: The clinical features between early onset and late onset neonatal septicemia are different,and the early onset disease is severe.The staphylococcus and escherichia coli are the main pathogens of septicemia.The clinical features and main pathogens of septicemia are the reference in antibiotics use,and the adjustment of antibiotics should accord to the bacterial culture result and drug sensitivity.
Objective: To analyze the clinical and etiologic features of neonatal septicemia.Methods: The clinical data of 124 neonatal septicemia cases from March 2013 to February 2017 were retrospectively analyzed.The patients were divided into the early onset group and late onset group according to the onset time,and the difference between two groups was compared.Results: The ratio of neonatal septicemia cases to the hospitalized newborns at the same time was 3.4%(124/3634),54.8% of which was the early onset type,and the major performances of which were jaundice,groans,cyanosis,dyspnea,responsiveness decreasing and C-reactive protein increasing.The 45.2% of patients were the late onset type,and the major performances of which were fever,dyspnea,jaundice,and focal infection.The incidence rates of the premature rupture of fetal membrane and amniotic fluid pollution in early onset group were higher than those in late onset group(P<0.05),the incidence rates of jaundice,groan,cyanosis,dyspnea and poor response in early onset group were significantly higher than those in late onset group(P<0.01).The incidence rate of the pneumonia complicated with focal infection in early onset group was lower than that in late onset group(P<0.01 and P<0.05).Among the septicaemic pathogens,88.7% of which was gram-positive bacteria,and 11.3% of which was gram-negative bacteria.The gram-positive bacteria was highly sensitive to vancomycin,minocycline and fusidic acid,and the gram-negative bacteria was highly sensitive to carbapenems.Conclusions: The clinical features between early onset and late onset neonatal septicemia are different,and the early onset disease is severe.The staphylococcus and escherichia coli are the main pathogens of septicemia.The clinical features and main pathogens of septicemia are the reference in antibiotics use,and the adjustment of antibiotics should accord to the bacterial culture result and drug sensitivity.
2018, 43(7): 892-895.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.014
Abstract:
Objective: To investigate application value of cryotherapy in the personalized treatment of cervical lesions.Methods: The high-risk HPV infection and low cervical precancerous lesions patients were investigated.The patients were treated with cervical cryotherapy,loop electrosurgical excision procedure(LEEP) and cervical laser surgery according to the age(25 to 30 years old) and fertility requirements(40 cases each group).The operation time,intraoperative blood loss,postoperative 3 months colposcopy,cervical contracture,length change of cervical canal between before and after treatment,postoperative 6 months negative conversion rate of HPV,postoperative 2 years fertility condition(including vaginal delivery and miscarriage) in three groups were observed.Results: The difference of operation time between LEEP and cervical laser surgery was not statistically significant(P>0.05),and which was shorter than that in cervical cryotherapy(P<0.01).No bleeding was found in cryosurgery operation,the intraoperative blood loss in LEEP was higher than that in laser surgery(P<0.01).During the 3 months of following-up,the differences of abnormal pathology rates among three groups were not statistically significant(P>0.05).The cervical contracture rate in cryotherapy was lower than that in LEEP surgery,and the difference of cervical contracture rate between laser surgery and LEEP was not statistically significant(P>0.05).No postoperative change of cervical tube length was found in cryotherapy surgery,and the cervical tube length change in LEEP surgery was more than that in laser surgery(P<0.01).The differences of the negative conversion rate of HPV at postoperative 6 months,and pregnant rate at postoperative 2 months among three groups were not statistically significant(P>0.05).The vaginal delivery rate in patients treated with cryotherapy(74.07%) was higher than that in the patients treated with LEEP(41.67%) and cervical cryotherapy(48.00%)(P<0.05),and the difference of which between LEEP and laser surgery patients was not statistically significant(P >0.05).The abortion rates in LEEP,laser surgery and cryotherapy pateints were 20.83%,8.00% and 0.00%,respectively,and which in patients treated with cryotherapy was lower than that in patients treated with LEEP(P<0.05).Conclusions: The cervical cryotherapy treatment does not have scar,change the cervical tube length,adhesion and contracture,and affect fertility function,which is suitable for young childless or retaining fertility requirements patients.
Objective: To investigate application value of cryotherapy in the personalized treatment of cervical lesions.Methods: The high-risk HPV infection and low cervical precancerous lesions patients were investigated.The patients were treated with cervical cryotherapy,loop electrosurgical excision procedure(LEEP) and cervical laser surgery according to the age(25 to 30 years old) and fertility requirements(40 cases each group).The operation time,intraoperative blood loss,postoperative 3 months colposcopy,cervical contracture,length change of cervical canal between before and after treatment,postoperative 6 months negative conversion rate of HPV,postoperative 2 years fertility condition(including vaginal delivery and miscarriage) in three groups were observed.Results: The difference of operation time between LEEP and cervical laser surgery was not statistically significant(P>0.05),and which was shorter than that in cervical cryotherapy(P<0.01).No bleeding was found in cryosurgery operation,the intraoperative blood loss in LEEP was higher than that in laser surgery(P<0.01).During the 3 months of following-up,the differences of abnormal pathology rates among three groups were not statistically significant(P>0.05).The cervical contracture rate in cryotherapy was lower than that in LEEP surgery,and the difference of cervical contracture rate between laser surgery and LEEP was not statistically significant(P>0.05).No postoperative change of cervical tube length was found in cryotherapy surgery,and the cervical tube length change in LEEP surgery was more than that in laser surgery(P<0.01).The differences of the negative conversion rate of HPV at postoperative 6 months,and pregnant rate at postoperative 2 months among three groups were not statistically significant(P>0.05).The vaginal delivery rate in patients treated with cryotherapy(74.07%) was higher than that in the patients treated with LEEP(41.67%) and cervical cryotherapy(48.00%)(P<0.05),and the difference of which between LEEP and laser surgery patients was not statistically significant(P >0.05).The abortion rates in LEEP,laser surgery and cryotherapy pateints were 20.83%,8.00% and 0.00%,respectively,and which in patients treated with cryotherapy was lower than that in patients treated with LEEP(P<0.05).Conclusions: The cervical cryotherapy treatment does not have scar,change the cervical tube length,adhesion and contracture,and affect fertility function,which is suitable for young childless or retaining fertility requirements patients.
2018, 43(7): 896-900.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.015
Abstract:
Objective: To investigate the effects of dexmedetomidine combined with pentazocine in the application of brachial plexus block.Methods: Sixty patients scheduled by operation were randomly divided into the simple brachial plexus group(D group),dexmedetomidine + brachial plexus group(G1 group),pentazocine + brachial plexus group(G2 group),and dexmedetomidine + spray pentazocine + brachial plexus group(G3group)(15 cases each group).D group was injected with 20 mL of 0.375% ropivacaine,G1 group was injected with 20 mL mixture of 0.375% ropivacaine and 0.5 μg/kg dexmedetomidine,G2 group was injected with 20 mL mixture of 0.375% ropivacaine and 0.5 mg/kg pentazocine,and G3 group was injected with 20 mL mixture of 0.375% ropivacaine,0.5 μg/kg dexmedetomidine and 0.5 mg/kg pentazocine.The MAP,HR and SpO2 in four groups before anesthesia and after 5,10,30,and 60 min of operation were recorded.The onset time of sensation and duration of pain disappearance were recorded.The patients with incomplete analgesia and changing anesthesia mode,and postoperative 6 h VAS score and Ramsay score in four groups were observed.Results: At postoperative 5,10,30 and 60 min,the MAP vlaues in G3,G2,G1 and D groups gradually increased,and the difference of which was statistically significant(P<0.01).At postoperative 5 and 10 min,the HR values in G2 and G3 groups were significantly lower than that in D group(P<0.05 and P<0.01).At postoperative 30 and 60 min,the HR values in G3,G2,G1 and D groups gradually increased,and the difference of which was statistically significant(P<0.01 to P<0.05).The differences of SpO2 values among four groups at all time-points were not statistically significant(P>0.05).The onset time of sensory block and duration of pain disappearance in G1,G2 and G3 groups were shorter than those in D group(P<0.01).The onset time of sensory block in G3 group was shorter than that in G1 group(P<0.01).The duration of pain disappearance in G3group was longer than that in G1 and G2 group (P<0.01).There was no statistical significance in the incidence rate of incomplete analgesia and changing anesthesia mode among four groups(P>0.05).At postoperative 6 h,the VAS score and Ramsay score in G3 group were significantly lower than that in D,G1 and G2 groups(P<0.01),and the differences of which among D,G1 and G2 groups were not statistically significant(P>0.05).Conclusions: The dexmedetomidine combined with pentazocine in the application of brachial plexus block anesthesia can enhance the sedative and analgesic effects,and is beneficial to the rapid recovery of postoperative patients.
Objective: To investigate the effects of dexmedetomidine combined with pentazocine in the application of brachial plexus block.Methods: Sixty patients scheduled by operation were randomly divided into the simple brachial plexus group(D group),dexmedetomidine + brachial plexus group(G1 group),pentazocine + brachial plexus group(G2 group),and dexmedetomidine + spray pentazocine + brachial plexus group(G3group)(15 cases each group).D group was injected with 20 mL of 0.375% ropivacaine,G1 group was injected with 20 mL mixture of 0.375% ropivacaine and 0.5 μg/kg dexmedetomidine,G2 group was injected with 20 mL mixture of 0.375% ropivacaine and 0.5 mg/kg pentazocine,and G3 group was injected with 20 mL mixture of 0.375% ropivacaine,0.5 μg/kg dexmedetomidine and 0.5 mg/kg pentazocine.The MAP,HR and SpO2 in four groups before anesthesia and after 5,10,30,and 60 min of operation were recorded.The onset time of sensation and duration of pain disappearance were recorded.The patients with incomplete analgesia and changing anesthesia mode,and postoperative 6 h VAS score and Ramsay score in four groups were observed.Results: At postoperative 5,10,30 and 60 min,the MAP vlaues in G3,G2,G1 and D groups gradually increased,and the difference of which was statistically significant(P<0.01).At postoperative 5 and 10 min,the HR values in G2 and G3 groups were significantly lower than that in D group(P<0.05 and P<0.01).At postoperative 30 and 60 min,the HR values in G3,G2,G1 and D groups gradually increased,and the difference of which was statistically significant(P<0.01 to P<0.05).The differences of SpO2 values among four groups at all time-points were not statistically significant(P>0.05).The onset time of sensory block and duration of pain disappearance in G1,G2 and G3 groups were shorter than those in D group(P<0.01).The onset time of sensory block in G3 group was shorter than that in G1 group(P<0.01).The duration of pain disappearance in G3group was longer than that in G1 and G2 group (P<0.01).There was no statistical significance in the incidence rate of incomplete analgesia and changing anesthesia mode among four groups(P>0.05).At postoperative 6 h,the VAS score and Ramsay score in G3 group were significantly lower than that in D,G1 and G2 groups(P<0.01),and the differences of which among D,G1 and G2 groups were not statistically significant(P>0.05).Conclusions: The dexmedetomidine combined with pentazocine in the application of brachial plexus block anesthesia can enhance the sedative and analgesic effects,and is beneficial to the rapid recovery of postoperative patients.
2018, 43(7): 900-903.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.016
Abstract:
Objective: To investigate the effects of granule fat transplantation on the life quality,self-confidence and self-image in patients with upper eyelid sinking.Methods: Eighty patients(160 eyes) with upper eyelid sinking were randomly divided into the block group 40 cases 80 eyes and particle group 40 cases 80 eyes according to random number table method.The block group and particle group were treated with double eyelid incision combined with block fat transplantation and granule fat transplantation,respectively.Two groups were followed up for 6 months.The scores of life quality,self-confidence and self-image between two groups were compared.Results: The operation time and peroperative bleeding in particle group were statistically lower than those in block group(P<0.01).The scores of operation result,quality of life,self-confidence and self-image in particle group were higher than those in block group(P<0.05 to P<0.01).The difference of the grading of upper eyelid sinking between before and after treatment in two groups was statistically significant(P<0.01).After treatment,the number of stage 1 patients in particle group was significantly higher than that in block group(P<0.05),and the satisfaction degree of particle group was significantly higher than that of block group(P<0.05).No incision infection and other serious complications were found in two groups during the following up of 12-26 months.Conclusions: Granular fat transplantation can effectively improve the quality of life,self-confidence and self-image of patients with the upper eyelid sinking.
Objective: To investigate the effects of granule fat transplantation on the life quality,self-confidence and self-image in patients with upper eyelid sinking.Methods: Eighty patients(160 eyes) with upper eyelid sinking were randomly divided into the block group 40 cases 80 eyes and particle group 40 cases 80 eyes according to random number table method.The block group and particle group were treated with double eyelid incision combined with block fat transplantation and granule fat transplantation,respectively.Two groups were followed up for 6 months.The scores of life quality,self-confidence and self-image between two groups were compared.Results: The operation time and peroperative bleeding in particle group were statistically lower than those in block group(P<0.01).The scores of operation result,quality of life,self-confidence and self-image in particle group were higher than those in block group(P<0.05 to P<0.01).The difference of the grading of upper eyelid sinking between before and after treatment in two groups was statistically significant(P<0.01).After treatment,the number of stage 1 patients in particle group was significantly higher than that in block group(P<0.05),and the satisfaction degree of particle group was significantly higher than that of block group(P<0.05).No incision infection and other serious complications were found in two groups during the following up of 12-26 months.Conclusions: Granular fat transplantation can effectively improve the quality of life,self-confidence and self-image of patients with the upper eyelid sinking.
2018, 43(7): 904-906,911.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.017
Abstract:
Objective: To explore the effects of the targeted infusion of propofol and remifentanil on the anesthesia effect and postoperative cognitive function in patients treated with laparoscopic cholecystectomy.Methods: The patients treated with laparoscopic cholecystectomy was divided into the control group and observation group.The control group was intravenously injected with propofol and fentanyl,and the observation group was treated with target infusion of propofol and remifentanil.Results: The differences of the systolic pressure,diastolic pressure and heart rate between two groups before and after intubation were not statistically significant(P>0.05),and the diastolic pressure and heart rate in two groups after intubation were higher than those before intubation(P<0.05 to P<0.01).The differences of the postoperative recovery time of spontaneous breathing,eye opening time,anesthesia time and extubation time between two groups were not statistically significant(P>0.05),and the recovery time of orientation in observation group was significantly shorter than that in control group(P<0.01).Compared with the extubation,after 24 h extubation,the OAAS score of the control group increased significantly and the NRS score decreased significantly(P<0.01),The score of OAAS and MMSE in the observation group increased significantly(P<0.01) and the NRS score decreased significantly(P<0.05),and the MMSE score of the 24 h observation group was significantly higher than that of the control group(P<0.05).The difference of the incidence rate of postoperative complications between two groups was not statistically significant(P>0.05).Conclusions: The targeted infusion of propofol and remifentanil in patients treated with laparoscopic cholecystectomy can sustain hemodynamics and improve the quality of sleep,which has good effect and is worthy of application and promotion.
Objective: To explore the effects of the targeted infusion of propofol and remifentanil on the anesthesia effect and postoperative cognitive function in patients treated with laparoscopic cholecystectomy.Methods: The patients treated with laparoscopic cholecystectomy was divided into the control group and observation group.The control group was intravenously injected with propofol and fentanyl,and the observation group was treated with target infusion of propofol and remifentanil.Results: The differences of the systolic pressure,diastolic pressure and heart rate between two groups before and after intubation were not statistically significant(P>0.05),and the diastolic pressure and heart rate in two groups after intubation were higher than those before intubation(P<0.05 to P<0.01).The differences of the postoperative recovery time of spontaneous breathing,eye opening time,anesthesia time and extubation time between two groups were not statistically significant(P>0.05),and the recovery time of orientation in observation group was significantly shorter than that in control group(P<0.01).Compared with the extubation,after 24 h extubation,the OAAS score of the control group increased significantly and the NRS score decreased significantly(P<0.01),The score of OAAS and MMSE in the observation group increased significantly(P<0.01) and the NRS score decreased significantly(P<0.05),and the MMSE score of the 24 h observation group was significantly higher than that of the control group(P<0.05).The difference of the incidence rate of postoperative complications between two groups was not statistically significant(P>0.05).Conclusions: The targeted infusion of propofol and remifentanil in patients treated with laparoscopic cholecystectomy can sustain hemodynamics and improve the quality of sleep,which has good effect and is worthy of application and promotion.
2018, 43(7): 907-911.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.018
Abstract:
Objective: To observe the expression levels of matrix metalloproteinases-9(MMP-9),type Ⅲ collagen and fibronectin(FN) in the serum and fetal membranes in women with premature rupture of membrane,and investigate their roles in premature rupture of membranes.Methods: Twenty women with preterm premature rupture of membranes,20 women with term fetal rupture of membranes and 20 women with normal full-term pregnancy were divided into the pPROM group,tPROM group and control group,respectively.The levels of MMP-9,type Ⅲ collagen and FN in the serum and fetal membranes in three groups were detected using the enzyme-linked immunosorbent assay and immunohistochemistry,and the results of those were analyzed.Results: The differences of the serum levels of MMP-9,type Ⅲ collagen and FN between three groups were statistically significant(P<0.01),the serum level of MMP-9 in tPROM group was significantly higher than that in pPROM group,and the serum level of MMP-9 in pPROM group was significantly higher than that in control group(P<0.01).The positive rates of MMP-9 in fetal membranes of pPROM group and tPROM group were significantly higher than that in control group(P<0.01),the positive rate of MMP-9 in tPROM group was significantly higher than that in pPROM group,and the difference of which between two groups was not statistically significant(P>0.05).The positive rates of type Ⅲ collagen and FN in fetal membranes of pPROM group and tPROM group were lower than that in control group(P<0.01),the positive rates of type Ⅲ collagen and FN in tPROM group was lower than that in pPROM group,and the difference of which between two group was not statistically significant(P>0.05).Among pPROM group and tPROM group,the level of MMP-9 was negatively related to the type Ⅲ collagen level(r=-0.874,r=-0.988,P<0.01),the level of MMP-9 was positively related to the FN level(r=-0.760,r=-0.875,P<0.01),and the level of type Ⅲ collagen was positively related to the FN level(r=0.529,r=0.876,P<0.05).In the fetal membrane tissue,the expression level of MMP-9 was negatively related to the level of type Ⅲ collagen(r=-0.468,P<0.01),the expression level of MMP-9 was negatively related to the level of type Ⅲ collagen(r=-0.493,P<0.01),and the level of type Ⅲ collagen was positively related to the level of FN(r=0.885,P<0.01).Conclusions: MMP-9,type Ⅲ collagen and FN are involved in the development of premature rupture of membranes.The levels of MMP-9 in serum and fetal membranes increasing and type Ⅲ collagen level decreasing can lead to the occurrence of premature rupture of fetal membranes.
Objective: To observe the expression levels of matrix metalloproteinases-9(MMP-9),type Ⅲ collagen and fibronectin(FN) in the serum and fetal membranes in women with premature rupture of membrane,and investigate their roles in premature rupture of membranes.Methods: Twenty women with preterm premature rupture of membranes,20 women with term fetal rupture of membranes and 20 women with normal full-term pregnancy were divided into the pPROM group,tPROM group and control group,respectively.The levels of MMP-9,type Ⅲ collagen and FN in the serum and fetal membranes in three groups were detected using the enzyme-linked immunosorbent assay and immunohistochemistry,and the results of those were analyzed.Results: The differences of the serum levels of MMP-9,type Ⅲ collagen and FN between three groups were statistically significant(P<0.01),the serum level of MMP-9 in tPROM group was significantly higher than that in pPROM group,and the serum level of MMP-9 in pPROM group was significantly higher than that in control group(P<0.01).The positive rates of MMP-9 in fetal membranes of pPROM group and tPROM group were significantly higher than that in control group(P<0.01),the positive rate of MMP-9 in tPROM group was significantly higher than that in pPROM group,and the difference of which between two groups was not statistically significant(P>0.05).The positive rates of type Ⅲ collagen and FN in fetal membranes of pPROM group and tPROM group were lower than that in control group(P<0.01),the positive rates of type Ⅲ collagen and FN in tPROM group was lower than that in pPROM group,and the difference of which between two group was not statistically significant(P>0.05).Among pPROM group and tPROM group,the level of MMP-9 was negatively related to the type Ⅲ collagen level(r=-0.874,r=-0.988,P<0.01),the level of MMP-9 was positively related to the FN level(r=-0.760,r=-0.875,P<0.01),and the level of type Ⅲ collagen was positively related to the FN level(r=0.529,r=0.876,P<0.05).In the fetal membrane tissue,the expression level of MMP-9 was negatively related to the level of type Ⅲ collagen(r=-0.468,P<0.01),the expression level of MMP-9 was negatively related to the level of type Ⅲ collagen(r=-0.493,P<0.01),and the level of type Ⅲ collagen was positively related to the level of FN(r=0.885,P<0.01).Conclusions: MMP-9,type Ⅲ collagen and FN are involved in the development of premature rupture of membranes.The levels of MMP-9 in serum and fetal membranes increasing and type Ⅲ collagen level decreasing can lead to the occurrence of premature rupture of fetal membranes.
2018, 43(7): 912-914.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.019
Abstract:
Objective: To investigate the effects of one-time root canal therapy in the treatment elderly pulp necrosis complicated with apical periodontitis.Methods: One hundred and thirty-eight elderly patients with pulp necrosis complicated with apical periodontitis were randomly divided into the observation group(n=71) and control group(n=67).Two groups were treated with machine Protaper NiTi files combined with ultrasonic washing the root canal.The observation group were treated with one-time root canal filling,and the control group were treated with secondary root canal filling.The pains in two groups were assessed before treatment and 7 d after operation,and the clinical effects in two groups were assessed 7 d,6 months,12 months and 24 months after operation.Results: The difference of the total effective rate between the observation group(91.55%) and control group(92.54%)7 d after operation was not statistically significant(P>0.05).The difference of the incidence rate of postoperative teeth pain between the observation group(11.27%) and control group(7.46%) was not statistically significant(P>0.05).The success rates in observation group 6 months,12 months and 24 months after operation were 74.19%,76.27% and 79.63%,respectively,and those in control group were 71.43%,72.41% and 68.09%,respectively.The differences of the success rates in postoperative different time-points between two groups were not statistically significant(P>0.05).Conclusions: The clinical effect of one-time root canal treatment in the treatment elderly pulp necrosis complicated with apical periodontitis is equivalent with the secondary root canal treatment,which can help to reduce the number of visits and shorten the course of treatment,and is safe and effective.
Objective: To investigate the effects of one-time root canal therapy in the treatment elderly pulp necrosis complicated with apical periodontitis.Methods: One hundred and thirty-eight elderly patients with pulp necrosis complicated with apical periodontitis were randomly divided into the observation group(n=71) and control group(n=67).Two groups were treated with machine Protaper NiTi files combined with ultrasonic washing the root canal.The observation group were treated with one-time root canal filling,and the control group were treated with secondary root canal filling.The pains in two groups were assessed before treatment and 7 d after operation,and the clinical effects in two groups were assessed 7 d,6 months,12 months and 24 months after operation.Results: The difference of the total effective rate between the observation group(91.55%) and control group(92.54%)7 d after operation was not statistically significant(P>0.05).The difference of the incidence rate of postoperative teeth pain between the observation group(11.27%) and control group(7.46%) was not statistically significant(P>0.05).The success rates in observation group 6 months,12 months and 24 months after operation were 74.19%,76.27% and 79.63%,respectively,and those in control group were 71.43%,72.41% and 68.09%,respectively.The differences of the success rates in postoperative different time-points between two groups were not statistically significant(P>0.05).Conclusions: The clinical effect of one-time root canal treatment in the treatment elderly pulp necrosis complicated with apical periodontitis is equivalent with the secondary root canal treatment,which can help to reduce the number of visits and shorten the course of treatment,and is safe and effective.
2018, 43(7): 915-918.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.020
Abstract:
Objective: To investigate the effects of periodontal basic treatment on plaque index(PLI),periodontal probing depth(PD) and expression levels of high sensitivity C reactive protein(hs-CRP) in serum and gingival crevicular fluid in patients with periodontitis.Methods: Sixty-four patients with chronic periodontitis and 64 healthy volunteers were divided into the case group and control group,respectively.The case group was treated with periodontal basic treatment.The PLI,PD,attachment loss(AL) and levels of hs-CRP,interleukin-6(IL-6),interleukin-8(IL-8) in serum and gingival crevicular fluid were observed in two groups.Results: Before and after treatment,the PD,PLI and AL in case group were significantly higher than those in control group(P<0.01).The PD,PLI and AL in case group after treatment significantly decreased compared with before treatment(P<0.01).Before and after treatment,the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid in case group were significantly higher than those in control group(P<0.01).The levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid in case group after treatment significantly decreased compared with before treatment(P<0.01).The PD was positively correlated with the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid(P<0.05),and the AL was positively correlated with the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid(P<0.05).Conclusions: Periodontal basic treatment can effectively improve the periodontal and inflammatory status in patients with periodontitis.
Objective: To investigate the effects of periodontal basic treatment on plaque index(PLI),periodontal probing depth(PD) and expression levels of high sensitivity C reactive protein(hs-CRP) in serum and gingival crevicular fluid in patients with periodontitis.Methods: Sixty-four patients with chronic periodontitis and 64 healthy volunteers were divided into the case group and control group,respectively.The case group was treated with periodontal basic treatment.The PLI,PD,attachment loss(AL) and levels of hs-CRP,interleukin-6(IL-6),interleukin-8(IL-8) in serum and gingival crevicular fluid were observed in two groups.Results: Before and after treatment,the PD,PLI and AL in case group were significantly higher than those in control group(P<0.01).The PD,PLI and AL in case group after treatment significantly decreased compared with before treatment(P<0.01).Before and after treatment,the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid in case group were significantly higher than those in control group(P<0.01).The levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid in case group after treatment significantly decreased compared with before treatment(P<0.01).The PD was positively correlated with the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid(P<0.05),and the AL was positively correlated with the levels of IL-6,IL-8 and hs-CRP in serum and gingival crevicular fluid(P<0.05).Conclusions: Periodontal basic treatment can effectively improve the periodontal and inflammatory status in patients with periodontitis.
2018, 43(7): 918-920.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.021
Abstract:
Objective: To observe the clinical efficacy of Nd:YAG laser in the treatment of dentine hypersensitivity.Methods: A total of 200 patients with dentine hypersensitivity(380 ill teeth) were randomly divided into the control group and observation group(100 cases each group).The observation group(200 ill teeth) were treated with Nd:YAG laser desensitization,and the control group(180 ill teeth) were treated with Gluma desensitizer.The clinical efficacy between two groups after 0 hour,1 week,1 month,3 months,6 month and 12 month of treatment were compared.Results: The differences of the effective rates between two groups after 0 hour,1 week,1 month and 3 months of treatment were not statistically significant(P>0.05),and the differences of the effective rates between two groups after 6 and 12 months of treatment were significant(P<0.05).Conclusions: The Nd:YAG laser in the treatment of dentine hypersensitivity has good middle and long-term clinical effects.
Objective: To observe the clinical efficacy of Nd:YAG laser in the treatment of dentine hypersensitivity.Methods: A total of 200 patients with dentine hypersensitivity(380 ill teeth) were randomly divided into the control group and observation group(100 cases each group).The observation group(200 ill teeth) were treated with Nd:YAG laser desensitization,and the control group(180 ill teeth) were treated with Gluma desensitizer.The clinical efficacy between two groups after 0 hour,1 week,1 month,3 months,6 month and 12 month of treatment were compared.Results: The differences of the effective rates between two groups after 0 hour,1 week,1 month and 3 months of treatment were not statistically significant(P>0.05),and the differences of the effective rates between two groups after 6 and 12 months of treatment were significant(P<0.05).Conclusions: The Nd:YAG laser in the treatment of dentine hypersensitivity has good middle and long-term clinical effects.
2018, 43(7): 931-932,937.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.026
Abstract:
Objective: To investigate the early health education condition of 0 to 3 years old children,and understand the early growth and development of children for providing early scientific education in Bengbu.Methods: The early health education situation in 0 to 3 years old children from five communities selected by stratified cluster sampling method were investigated using self-programmed of early childhood health education questionnaire,psychological consultation and hospital cooperation way.Results: The 78.1% of children aged 0-3 years old were non-intergenerational reared,21.9% of children were intergenerational reared,and the difference of which was statistically significant(P<0.01).Breast-feeding accounted for 18.1%,85.7% of parents believed that the early healthy education was important in the growth and development of children,and 66.7% of educators hoped that the early education knowledge could be acquired through field visits.Conclusions: The early health education of children aged 0-3 years in Bengbu city needs to be improved,and the main education and early education base should be strengthened to promote the comprehensively healthy development.
Objective: To investigate the early health education condition of 0 to 3 years old children,and understand the early growth and development of children for providing early scientific education in Bengbu.Methods: The early health education situation in 0 to 3 years old children from five communities selected by stratified cluster sampling method were investigated using self-programmed of early childhood health education questionnaire,psychological consultation and hospital cooperation way.Results: The 78.1% of children aged 0-3 years old were non-intergenerational reared,21.9% of children were intergenerational reared,and the difference of which was statistically significant(P<0.01).Breast-feeding accounted for 18.1%,85.7% of parents believed that the early healthy education was important in the growth and development of children,and 66.7% of educators hoped that the early education knowledge could be acquired through field visits.Conclusions: The early health education of children aged 0-3 years in Bengbu city needs to be improved,and the main education and early education base should be strengthened to promote the comprehensively healthy development.
2018, 43(7): 933-937.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.027
Abstract:
Objective: To explore the mediating effect of emotion management between attachment and interaction anxiety in rural junior school students.Methods: Nine hundred and seventy-six junior school students from northern Anhui were investigated using the general condition questionnaire,Parent-child Attachment scale,Emotional Management scale and Interaction Anxiousness scale.The mediating effect of emotion management between attachment and interaction anxiety was analyzed.Results: The score of boys with father attachment was higher than that in girl with father attachment(P<0.05),and the differences of interaction anxiety,emotion management,mother attachment and peer attachment scores between boy and girl were not statistically significant(P>0.05).With the improvement of family economic condition,the level of students' communication anxiety gradually reduced(P<0.01),and the scores of emotional management and parent-child attachment of students with general and rich families were higher of students with poor families(P<0.05 to P<0.01).The scores of father attachment,mother attachment and peer attachment were positively correlated to emotional management(P<0.01),and the scores of emotional management,parents attachment and peer attachment were negatively correlated to social anxiety(P<0.01).The mediating effect of emotional management between attachment(mother attachment,father attachment and peer attachment) and interaction anxiety was found,the ratio of whose were 34.6%,40.0% and 25.5%,respectively.Conclusions: Emotion management plays a mediating effect between attachment and interaction anxiety,and the good emotion management can reduce the level of interaction anxiety in junior school students.
Objective: To explore the mediating effect of emotion management between attachment and interaction anxiety in rural junior school students.Methods: Nine hundred and seventy-six junior school students from northern Anhui were investigated using the general condition questionnaire,Parent-child Attachment scale,Emotional Management scale and Interaction Anxiousness scale.The mediating effect of emotion management between attachment and interaction anxiety was analyzed.Results: The score of boys with father attachment was higher than that in girl with father attachment(P<0.05),and the differences of interaction anxiety,emotion management,mother attachment and peer attachment scores between boy and girl were not statistically significant(P>0.05).With the improvement of family economic condition,the level of students' communication anxiety gradually reduced(P<0.01),and the scores of emotional management and parent-child attachment of students with general and rich families were higher of students with poor families(P<0.05 to P<0.01).The scores of father attachment,mother attachment and peer attachment were positively correlated to emotional management(P<0.01),and the scores of emotional management,parents attachment and peer attachment were negatively correlated to social anxiety(P<0.01).The mediating effect of emotional management between attachment(mother attachment,father attachment and peer attachment) and interaction anxiety was found,the ratio of whose were 34.6%,40.0% and 25.5%,respectively.Conclusions: Emotion management plays a mediating effect between attachment and interaction anxiety,and the good emotion management can reduce the level of interaction anxiety in junior school students.
2018, 43(7): 938-940,944.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.028
Abstract:
Objective: To investigate the effects of the self-management ability training on disease management and quality of life in patients with lupus nephritis.Methods: One hundred and twenty patients with lupus nephritis were randomly divided into the observation group(n=60) and control group(n=60).The control group and observation were managed with routine care and self-management skills training,respectively.The disease management ability and quality of life in two groups before and after intervention were evaluated using self-care ability scale and comprehensive assessment questionnaire(GQOLI-74).Results: After intervention,the scores of symptom management,emotional management,self-efficacy,information management and management of daily life in observation group were significantly higher than those in control group(P<0.01).After intervention,the scores of material life,social function,physical function,mental function and quality of life in observation group were significantly higher than those in control group(P<0.01).Conclusions: Self-management program can effectively improve the disease management ability and quality of life in patients with lupus nephritis.
Objective: To investigate the effects of the self-management ability training on disease management and quality of life in patients with lupus nephritis.Methods: One hundred and twenty patients with lupus nephritis were randomly divided into the observation group(n=60) and control group(n=60).The control group and observation were managed with routine care and self-management skills training,respectively.The disease management ability and quality of life in two groups before and after intervention were evaluated using self-care ability scale and comprehensive assessment questionnaire(GQOLI-74).Results: After intervention,the scores of symptom management,emotional management,self-efficacy,information management and management of daily life in observation group were significantly higher than those in control group(P<0.01).After intervention,the scores of material life,social function,physical function,mental function and quality of life in observation group were significantly higher than those in control group(P<0.01).Conclusions: Self-management program can effectively improve the disease management ability and quality of life in patients with lupus nephritis.
2018, 43(7): 941-944.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.029
Abstract:
Objective: To evaluate the quality of life,observe the physiological,psychological and social role needs,and provide the related nursing measures for palliative treatment and hospice care in patients with advanced esophageal cancer.Methods: The prospective intervention study approach was employed.The quality of life in 53 patients with advanced esophageal cancer(observation group) were evaluated using WHOQOL-BREF scale,the comprehensive quality nursing measures were implemented in combination with other situation of patients,and the related nursing measure of hospice care was additionally implemented in critically severe patients.Fifty-one patients with advanced esophageal cancer were nursed with routine approach(control group).The quality of life between two groups at the end of nursing was compared.Results: The comparison results of the late life quality score showed that the differences of subjective feeling of health and life quality,physiological,psychological,social relations and environmental fields between two groups were statistically significant(P<0.01).Among a total of 24 evaluation items,the differences of the lose sleep and rest,dependence on drugs and treatment,life interest(positive emotion),spiritual support,interpersonal relations,pain and discomfort between two groups were statistically significant(P<0.05).Conclusions: The related nursing measures for palliative treatment and hospice care in patients with advanced esophageal cancer can maintain the physiological function,adjust state of mind,improve the social function and quality of life of patients.
Objective: To evaluate the quality of life,observe the physiological,psychological and social role needs,and provide the related nursing measures for palliative treatment and hospice care in patients with advanced esophageal cancer.Methods: The prospective intervention study approach was employed.The quality of life in 53 patients with advanced esophageal cancer(observation group) were evaluated using WHOQOL-BREF scale,the comprehensive quality nursing measures were implemented in combination with other situation of patients,and the related nursing measure of hospice care was additionally implemented in critically severe patients.Fifty-one patients with advanced esophageal cancer were nursed with routine approach(control group).The quality of life between two groups at the end of nursing was compared.Results: The comparison results of the late life quality score showed that the differences of subjective feeling of health and life quality,physiological,psychological,social relations and environmental fields between two groups were statistically significant(P<0.01).Among a total of 24 evaluation items,the differences of the lose sleep and rest,dependence on drugs and treatment,life interest(positive emotion),spiritual support,interpersonal relations,pain and discomfort between two groups were statistically significant(P<0.05).Conclusions: The related nursing measures for palliative treatment and hospice care in patients with advanced esophageal cancer can maintain the physiological function,adjust state of mind,improve the social function and quality of life of patients.
2018, 43(7): 945-947,949.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.030
Abstract:
Objective: To investigate the pre-set catheter length measured by surface and ideal position in peripherally inserted central catheter(PICC) for providing a more accurate method in determining the pre-set catheter length in clinic.Methods: One hundred and thirty-two patients treated with PICC were randomly divided into group A,B and C.Group A was treated with right-diameter pre-set catheter(the length for surface length plus 3 cm),group B was treated with left-diameter pre-set catheter(the length for surface length plus 3 cm),and group C was treated with left-diameter pre-set catheter(the length for surface length plus 5 cm).The ideal pre-set catheter position was determined using an X-ray film,and the correlation and linear regression relationship between the left-,right-diameter pre-set catheter length and ideal position in body were analyzed.Results: The pre-set catheter length of PICC in group A and C was significantly associated with the ideal catheter length(P<0.01),and the corresponding regression equation was draw.Conclusions: The pre-set catheter length measured by surface in PICC is significantly related to the ideal position.
Objective: To investigate the pre-set catheter length measured by surface and ideal position in peripherally inserted central catheter(PICC) for providing a more accurate method in determining the pre-set catheter length in clinic.Methods: One hundred and thirty-two patients treated with PICC were randomly divided into group A,B and C.Group A was treated with right-diameter pre-set catheter(the length for surface length plus 3 cm),group B was treated with left-diameter pre-set catheter(the length for surface length plus 3 cm),and group C was treated with left-diameter pre-set catheter(the length for surface length plus 5 cm).The ideal pre-set catheter position was determined using an X-ray film,and the correlation and linear regression relationship between the left-,right-diameter pre-set catheter length and ideal position in body were analyzed.Results: The pre-set catheter length of PICC in group A and C was significantly associated with the ideal catheter length(P<0.01),and the corresponding regression equation was draw.Conclusions: The pre-set catheter length measured by surface in PICC is significantly related to the ideal position.
2018, 43(7): 955-957.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.034
Abstract:
Objective: To evaluate the effects of open experiment teaching on cultivating innovation ability of undergraduates in Preventive Medicine speciality.Methods: Sixty undergraduates from grade 2016 Preventive Medicine speciality were divided into the observation group and control group(30 students each group).The observation group was taught with traditional experiment teaching combined with open experiment teaching,and the control group was taught with traditional experiment teaching.The innovation abilities between two groups were comprehensively evaluated in 2017.Results: The evaluation results showed that the environmental health,nutrition and food health,health care big data,and aging population between two groups were statistically significant(P<0.05 to P<0.01).The teaching effects on the innovation awareness and ability,critical thinking,teamwork spirit,wide vision and literature research ability in observation group were better than those in control group(P<0.05 to P<0.01).Compared with the control group,more students in observation group thought that the experimental course was very helpful for professional study,and future work and development(P<0.05 and P<0.01).Conclusions: The open experiment teaching reform is an important way to improve the experiment teaching effect in Preventive Medicine speciality undergraduates,which can improve the subjective initiative,creativity and professional quality.
Objective: To evaluate the effects of open experiment teaching on cultivating innovation ability of undergraduates in Preventive Medicine speciality.Methods: Sixty undergraduates from grade 2016 Preventive Medicine speciality were divided into the observation group and control group(30 students each group).The observation group was taught with traditional experiment teaching combined with open experiment teaching,and the control group was taught with traditional experiment teaching.The innovation abilities between two groups were comprehensively evaluated in 2017.Results: The evaluation results showed that the environmental health,nutrition and food health,health care big data,and aging population between two groups were statistically significant(P<0.05 to P<0.01).The teaching effects on the innovation awareness and ability,critical thinking,teamwork spirit,wide vision and literature research ability in observation group were better than those in control group(P<0.05 to P<0.01).Compared with the control group,more students in observation group thought that the experimental course was very helpful for professional study,and future work and development(P<0.05 and P<0.01).Conclusions: The open experiment teaching reform is an important way to improve the experiment teaching effect in Preventive Medicine speciality undergraduates,which can improve the subjective initiative,creativity and professional quality.
2018, 43(7): 958-961.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.035
Abstract:
Objective: To explore the guiding significance of medical simulation assessment proposition thinking and methods for clinical teaching.Methods: Combining twoyears of propositional experience of the National Medical College Students Clinical Skills Competition,clinical medical characteristics were summarized and analyzed.Results: Propositions should be based on how to strengthen the clinical foundation, clinical thinking,basic operations,human care and doctor-patient communication.The questions should include:content and purpose of assessment,stem,clinical thinking process and setting in the case scenario,the stem contains the core system,operational norms,human care and doctor-patient communication.The proposition should also pay attention to the refinement of the problem,the model of the simulation operation should be available,and the operation environment should be safe.Conclusions: The moreclose to the clinic,clinical thinking and objective in the competition,the better.
Objective: To explore the guiding significance of medical simulation assessment proposition thinking and methods for clinical teaching.Methods: Combining twoyears of propositional experience of the National Medical College Students Clinical Skills Competition,clinical medical characteristics were summarized and analyzed.Results: Propositions should be based on how to strengthen the clinical foundation, clinical thinking,basic operations,human care and doctor-patient communication.The questions should include:content and purpose of assessment,stem,clinical thinking process and setting in the case scenario,the stem contains the core system,operational norms,human care and doctor-patient communication.The proposition should also pay attention to the refinement of the problem,the model of the simulation operation should be available,and the operation environment should be safe.Conclusions: The moreclose to the clinic,clinical thinking and objective in the competition,the better.
2018, 43(7): 962-964.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.036
Abstract:
Objective: To investigate the training condition of general practitioners(GP) in Anhui province,explore the problems during the GP training,and put forward corresponding countermeasures.Methods: By the convenient sampling method,195 GPs in community hospital or township health center from Anhui province were investigated using self-made questionnaire.Results: The 30.8% GPs learned the medical knowledge in short-term training.The ratio of the GPs participatng training in recent 2 years was 72.4%,the ratios of "significantly","in a certain extent",and "no effect" in the ability and knowledge training were 46.9%,50.4% and 2.7%,respectively.The ratios of "training content no help very much","no time because of work","economic problem" "the leader no plan" among the reasons for no participating training were 30.8%,25.6%,23.1% and 17.9%,respectively.In the organization mode of training,the large disparity of the proportions of participants and high assessment in township health center were 17.7% and 48.1%,in superior doctors guidance were 27.4% and 55.1%,in clinical training were 37.25% and 75.0%,and in traditional Chinese medicine technology training were 19.5% and 48.7%.There was statistical significance in the sense of work competence of whether to participate in the training between two groups(P<0.01).Conclusions: The training system and content are the main reasons of low participation rate,and the training organization can not fully meet the needs of the GPs.The training system should be improved to increase the training effects.
Objective: To investigate the training condition of general practitioners(GP) in Anhui province,explore the problems during the GP training,and put forward corresponding countermeasures.Methods: By the convenient sampling method,195 GPs in community hospital or township health center from Anhui province were investigated using self-made questionnaire.Results: The 30.8% GPs learned the medical knowledge in short-term training.The ratio of the GPs participatng training in recent 2 years was 72.4%,the ratios of "significantly","in a certain extent",and "no effect" in the ability and knowledge training were 46.9%,50.4% and 2.7%,respectively.The ratios of "training content no help very much","no time because of work","economic problem" "the leader no plan" among the reasons for no participating training were 30.8%,25.6%,23.1% and 17.9%,respectively.In the organization mode of training,the large disparity of the proportions of participants and high assessment in township health center were 17.7% and 48.1%,in superior doctors guidance were 27.4% and 55.1%,in clinical training were 37.25% and 75.0%,and in traditional Chinese medicine technology training were 19.5% and 48.7%.There was statistical significance in the sense of work competence of whether to participate in the training between two groups(P<0.01).Conclusions: The training system and content are the main reasons of low participation rate,and the training organization can not fully meet the needs of the GPs.The training system should be improved to increase the training effects.
2018, 43(7): 965-966.
doi: 10.13898/j.cnki.issn.1000-2200.2018.07.037
Abstract:
Objective: To explore the application effects of systematic dental extraction training in the teaching of oral and maxillofacial surgery.Methods: Twenty-four oral and maxillofacial surgery interns were divided into the routine training group and systematic dental extraction training group.The teeth with the same extraction difficulty were equally allocated to two groups.The tooth extraction time,and incidence rates of tooth extraction pain,intraoperative and postoperative complications between two groups were compared.Results: Compared with the routine training group,the score of the dental extraction pain visual analogue scale,extraction time,and incidence rates of intraoperative and postoperative complications in systematic dental extraction training group significantly decreased(P<0.01).Conclusions: The systematic dental extraction training is helpful to improve the teaching quality and medical safety of oral and maxillofacial surgery interns.
Objective: To explore the application effects of systematic dental extraction training in the teaching of oral and maxillofacial surgery.Methods: Twenty-four oral and maxillofacial surgery interns were divided into the routine training group and systematic dental extraction training group.The teeth with the same extraction difficulty were equally allocated to two groups.The tooth extraction time,and incidence rates of tooth extraction pain,intraoperative and postoperative complications between two groups were compared.Results: Compared with the routine training group,the score of the dental extraction pain visual analogue scale,extraction time,and incidence rates of intraoperative and postoperative complications in systematic dental extraction training group significantly decreased(P<0.01).Conclusions: The systematic dental extraction training is helpful to improve the teaching quality and medical safety of oral and maxillofacial surgery interns.
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